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Overview

ID MAG04015
Name TLS2_bin.55
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Longimicrobiales
Family RSA9
Genus SH-MAG3
Species
Assembly information
Completeness (%) 92.91
Contamination (%) 3.15
GC content (%) 66.0
N50 (bp) 85,012
Genome size (bp) 4,858,892

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3848

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_10484_0 TonB dependent receptor - - - 6.092e-240 773.0
TLS2_k127_10484_1 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 593.0
TLS2_k127_10484_10 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 455.0
TLS2_k127_10484_11 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 402.0
TLS2_k127_10484_12 PFAM extracellular solute-binding protein family 1 K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 381.0
TLS2_k127_10484_13 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 370.0
TLS2_k127_10484_14 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 353.0
TLS2_k127_10484_15 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 342.0
TLS2_k127_10484_16 Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 329.0
TLS2_k127_10484_17 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 319.0
TLS2_k127_10484_18 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 303.0
TLS2_k127_10484_19 Transcriptional regulatory protein, C terminal K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003928 279.0
TLS2_k127_10484_2 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007157 547.0
TLS2_k127_10484_20 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001272 292.0
TLS2_k127_10484_21 HAMP domain K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001727 289.0
TLS2_k127_10484_22 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000007922 266.0
TLS2_k127_10484_23 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001372 245.0
TLS2_k127_10484_24 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000006683 224.0
TLS2_k127_10484_25 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000000000000000000000002959 219.0
TLS2_k127_10484_26 PFAM transglutaminase domain protein - - - 0.000000000000000000000000000000000000000000000000000005298 209.0
TLS2_k127_10484_27 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000001254 190.0
TLS2_k127_10484_28 Enoyl-CoA hydratase K07537 - 4.2.1.100 0.000000000000000000000000000000000000000000008065 172.0
TLS2_k127_10484_29 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000005376 159.0
TLS2_k127_10484_3 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 521.0
TLS2_k127_10484_30 Protein of unknown function (DUF445) - - - 0.000000000000000000000000000000000000001756 165.0
TLS2_k127_10484_31 Tetratricopeptide repeat - - - 0.000000000000000000000000000001079 126.0
TLS2_k127_10484_32 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000001957 124.0
TLS2_k127_10484_33 Divalent ion tolerance protein K03926 - - 0.0000000000000000000000000005277 117.0
TLS2_k127_10484_34 - - - - 0.000000000000000000000004773 113.0
TLS2_k127_10484_35 IMP dehydrogenase activity - GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0030312,GO:0035821,GO:0036293,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0070482,GO:0071944,GO:0075136 - 0.00000000000000000000001018 106.0
TLS2_k127_10484_36 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000001225 106.0
TLS2_k127_10484_37 Redox protein regulator of disulfide bond formation K07397 - - 0.00000000000000000004888 95.0
TLS2_k127_10484_38 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000007128 94.0
TLS2_k127_10484_39 Thioesterase superfamily K07107 - - 0.000000000000000002754 94.0
TLS2_k127_10484_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 505.0
TLS2_k127_10484_41 TPR repeat - - - 0.000000000004128 76.0
TLS2_k127_10484_42 - - - - 0.000000003 65.0
TLS2_k127_10484_43 Domain of unknown function (DUF296) K06934 - - 0.0000001392 59.0
TLS2_k127_10484_44 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000002742 57.0
TLS2_k127_10484_45 Prolyl oligopeptidase family - - - 0.0000002746 53.0
TLS2_k127_10484_46 PRC-barrel domain - - - 0.000002014 60.0
TLS2_k127_10484_47 Protein of unknown function (DUF1499) - - - 0.000002613 56.0
TLS2_k127_10484_48 - - - - 0.000003532 55.0
TLS2_k127_10484_49 PFAM Phosphate-selective porin O and P - - - 0.000006235 58.0
TLS2_k127_10484_5 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 518.0
TLS2_k127_10484_50 PRC-barrel domain - - - 0.000008128 58.0
TLS2_k127_10484_51 Acid phosphatase homologues K19302 - 3.6.1.27 0.00001226 51.0
TLS2_k127_10484_52 Domain of unknown function (DUF4399) - - - 0.00001497 53.0
TLS2_k127_10484_53 - - - - 0.0001077 53.0
TLS2_k127_10484_54 - - - - 0.0001414 53.0
TLS2_k127_10484_56 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0006705 49.0
TLS2_k127_10484_57 Protein of unknown function (DUF1698) - - - 0.0008446 50.0
TLS2_k127_10484_6 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 502.0
TLS2_k127_10484_7 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 473.0
TLS2_k127_10484_8 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 482.0
TLS2_k127_10484_9 Putative ATP-binding cassette K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 479.0
TLS2_k127_1096380_0 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 546.0
TLS2_k127_1096380_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 292.0
TLS2_k127_11309_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1150.0
TLS2_k127_11309_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 7.86e-300 936.0
TLS2_k127_11309_10 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007776 497.0
TLS2_k127_11309_100 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000008618 104.0
TLS2_k127_11309_101 Binds the 23S rRNA K02909 - - 0.000000000000000000000001062 104.0
TLS2_k127_11309_102 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000008015 106.0
TLS2_k127_11309_103 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.00000000000000000000001091 112.0
TLS2_k127_11309_104 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000002997 102.0
TLS2_k127_11309_105 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000007416 110.0
TLS2_k127_11309_106 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.0000000000000000000001072 102.0
TLS2_k127_11309_107 Universal bacterial protein YeaZ K14742 - - 0.000000000000000000004785 101.0
TLS2_k127_11309_108 PFAM Cytochrome c assembly protein - - - 0.00000000000000000002073 101.0
TLS2_k127_11309_109 Control of competence regulator ComK, YlbF/YmcA - - - 0.0000000000000000002312 93.0
TLS2_k127_11309_11 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 445.0
TLS2_k127_11309_110 TonB C terminal K03832 - - 0.0000000000000000002777 97.0
TLS2_k127_11309_111 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000004883 86.0
TLS2_k127_11309_112 polysaccharide export protein K01991 - - 0.0000000000000008947 85.0
TLS2_k127_11309_113 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000008188 78.0
TLS2_k127_11309_114 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840 - 0.0000000000001301 81.0
TLS2_k127_11309_115 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000002127 71.0
TLS2_k127_11309_116 Ribosomal protein L36 K02919 - - 0.000000000005207 74.0
TLS2_k127_11309_117 positive regulation of growth rate - - - 0.00000000001937 76.0
TLS2_k127_11309_118 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000002462 67.0
TLS2_k127_11309_119 Zn-ribbon protein, possibly nucleic acid-binding K07164 - - 0.000000000068 71.0
TLS2_k127_11309_12 DHH family K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 453.0
TLS2_k127_11309_120 O-Antigen ligase - - - 0.0000000002877 73.0
TLS2_k127_11309_121 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000002936 66.0
TLS2_k127_11309_122 Domain of unknown function (DUF4321) - - - 0.000000006998 61.0
TLS2_k127_11309_123 Tetratricopeptide repeat - - - 0.0000006269 63.0
TLS2_k127_11309_124 PFAM Tetratricopeptide - - - 0.00004163 55.0
TLS2_k127_11309_13 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 454.0
TLS2_k127_11309_14 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 428.0
TLS2_k127_11309_15 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 422.0
TLS2_k127_11309_16 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000819 413.0
TLS2_k127_11309_17 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 394.0
TLS2_k127_11309_18 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 396.0
TLS2_k127_11309_19 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 381.0
TLS2_k127_11309_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 2.368e-274 862.0
TLS2_k127_11309_20 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 376.0
TLS2_k127_11309_21 Polyprenyl synthetase K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 374.0
TLS2_k127_11309_22 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 371.0
TLS2_k127_11309_23 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006889 378.0
TLS2_k127_11309_24 Amidohydrolase family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 364.0
TLS2_k127_11309_25 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 360.0
TLS2_k127_11309_26 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 347.0
TLS2_k127_11309_27 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000765 340.0
TLS2_k127_11309_28 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 348.0
TLS2_k127_11309_29 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003858 338.0
TLS2_k127_11309_3 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 3.055e-209 658.0
TLS2_k127_11309_30 GHMP kinase domain protein K07031 - 2.7.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 331.0
TLS2_k127_11309_31 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004361 327.0
TLS2_k127_11309_32 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 330.0
TLS2_k127_11309_33 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 308.0
TLS2_k127_11309_34 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 286.0
TLS2_k127_11309_35 SurA N-terminal domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 308.0
TLS2_k127_11309_36 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000751 302.0
TLS2_k127_11309_37 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006822 265.0
TLS2_k127_11309_38 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003328 270.0
TLS2_k127_11309_39 D-glycero-D-manno-heptose 7-phosphate metabolic process K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000006579 258.0
TLS2_k127_11309_4 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 1.885e-208 657.0
TLS2_k127_11309_40 polysaccharide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001449 268.0
TLS2_k127_11309_41 Regulator of chromosome condensation (RCC1) repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002297 263.0
TLS2_k127_11309_42 Homoserine dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008775 263.0
TLS2_k127_11309_43 Capsule assembly protein Wzi - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001035 262.0
TLS2_k127_11309_44 CobQ CobB MinD ParA nucleotide binding domain K16554,K16692 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001482 270.0
TLS2_k127_11309_45 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001685 256.0
TLS2_k127_11309_46 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000006848 244.0
TLS2_k127_11309_47 Transaldolase K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000003579 239.0
TLS2_k127_11309_48 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000001005 233.0
TLS2_k127_11309_49 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000704 231.0
TLS2_k127_11309_5 Ftsk_gamma K03466 - - 5.788e-201 650.0
TLS2_k127_11309_50 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000002485 231.0
TLS2_k127_11309_51 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000002658 235.0
TLS2_k127_11309_52 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000002103 222.0
TLS2_k127_11309_53 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 0.0000000000000000000000000000000000000000000000000000000000000009675 233.0
TLS2_k127_11309_54 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000001741 226.0
TLS2_k127_11309_55 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000218 221.0
TLS2_k127_11309_56 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000004231 215.0
TLS2_k127_11309_57 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000009131 206.0
TLS2_k127_11309_58 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000003121 209.0
TLS2_k127_11309_59 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000001197 200.0
TLS2_k127_11309_6 UDP binding domain K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 558.0
TLS2_k127_11309_60 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000002663 211.0
TLS2_k127_11309_61 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000007524 201.0
TLS2_k127_11309_62 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000001097 218.0
TLS2_k127_11309_63 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000000000000000000000000000000001124 209.0
TLS2_k127_11309_64 sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000001037 207.0
TLS2_k127_11309_65 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000002381 183.0
TLS2_k127_11309_66 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000004541 192.0
TLS2_k127_11309_67 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000001416 183.0
TLS2_k127_11309_68 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000002715 185.0
TLS2_k127_11309_69 PFAM glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000006772 196.0
TLS2_k127_11309_7 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 531.0
TLS2_k127_11309_70 Met-10+ like-protein K02687 - - 0.00000000000000000000000000000000000000000000000659 183.0
TLS2_k127_11309_71 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000002077 175.0
TLS2_k127_11309_72 Belongs to the ComB family K05979 - 3.1.3.71 0.0000000000000000000000000000000000000000000001824 177.0
TLS2_k127_11309_73 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000001041 171.0
TLS2_k127_11309_74 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000001627 166.0
TLS2_k127_11309_75 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000004492 160.0
TLS2_k127_11309_76 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.00000000000000000000000000000000000000001177 168.0
TLS2_k127_11309_77 Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000003768 160.0
TLS2_k127_11309_78 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000006979 152.0
TLS2_k127_11309_79 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000001462 155.0
TLS2_k127_11309_8 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007514 530.0
TLS2_k127_11309_80 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000003759 151.0
TLS2_k127_11309_81 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000004928 154.0
TLS2_k127_11309_82 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000006925 154.0
TLS2_k127_11309_83 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000263 152.0
TLS2_k127_11309_84 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000002162 160.0
TLS2_k127_11309_85 OmpA family K03640 - - 0.00000000000000000000000000000000003437 141.0
TLS2_k127_11309_86 structural constituent of ribosome K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000001125 137.0
TLS2_k127_11309_87 TPR repeat - - - 0.000000000000000000000000000000001182 140.0
TLS2_k127_11309_88 Yqey-like protein K09117 - - 0.000000000000000000000000000000001244 134.0
TLS2_k127_11309_89 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000386 126.0
TLS2_k127_11309_9 intramolecular transferase activity, transferring amino groups K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 511.0
TLS2_k127_11309_90 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000005575 131.0
TLS2_k127_11309_91 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000008954 128.0
TLS2_k127_11309_92 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000523 133.0
TLS2_k127_11309_93 PFAM transferase hexapeptide repeat containing protein - - - 0.000000000000000000000000000007001 129.0
TLS2_k127_11309_94 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000007188 119.0
TLS2_k127_11309_95 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000001235 126.0
TLS2_k127_11309_96 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000002024 116.0
TLS2_k127_11309_97 Outer membrane lipoprotein K05807 - - 0.0000000000000000000000000003428 123.0
TLS2_k127_11309_98 MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000005705 124.0
TLS2_k127_11309_99 Transcription termination factor nusG - - - 0.00000000000000000000000001591 116.0
TLS2_k127_1244405_0 PA14 domain K05349 - 3.2.1.21 0.0 1069.0
TLS2_k127_1244405_1 lysine biosynthetic process via aminoadipic acid - - - 4.325e-262 833.0
TLS2_k127_1244405_10 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) K01083 - 3.1.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001075 291.0
TLS2_k127_1244405_11 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002324 239.0
TLS2_k127_1244405_12 PFAM helicase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000002547 236.0
TLS2_k127_1244405_13 Protein of unknown function (DUF998) - - - 0.00000000000000000000000000000000000000000000000000000000002838 214.0
TLS2_k127_1244405_14 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000003119 203.0
TLS2_k127_1244405_15 Protein of unknown function, DUF480 K09915 - - 0.000000000000000000000000000000000000000000000000002854 189.0
TLS2_k127_1244405_16 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000009751 171.0
TLS2_k127_1244405_17 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000452 167.0
TLS2_k127_1244405_18 - - - - 0.0000000000000000000000000002924 126.0
TLS2_k127_1244405_19 negative regulation of transcription, DNA-templated - - - 0.000000000000000001563 89.0
TLS2_k127_1244405_2 Protein of unknown function, DUF255 K06888 - - 1.816e-254 813.0
TLS2_k127_1244405_3 Alpha-L-fucosidase K01206 - 3.2.1.51 2.547e-205 650.0
TLS2_k127_1244405_4 DNA restriction-modification system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 441.0
TLS2_k127_1244405_5 membrane organization - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009924 412.0
TLS2_k127_1244405_6 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 394.0
TLS2_k127_1244405_7 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 357.0
TLS2_k127_1244405_8 KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009096 356.0
TLS2_k127_1244405_9 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004508 362.0
TLS2_k127_1245583_0 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 2.681e-312 977.0
TLS2_k127_1245583_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 6.696e-201 632.0
TLS2_k127_1245583_10 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 429.0
TLS2_k127_1245583_11 ATP:guanido phosphotransferase, C-terminal catalytic domain K19405 - 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 426.0
TLS2_k127_1245583_12 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006717 417.0
TLS2_k127_1245583_13 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008524 402.0
TLS2_k127_1245583_14 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 347.0
TLS2_k127_1245583_15 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009344 344.0
TLS2_k127_1245583_16 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 336.0
TLS2_k127_1245583_17 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 314.0
TLS2_k127_1245583_18 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 305.0
TLS2_k127_1245583_19 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 302.0
TLS2_k127_1245583_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 9.915e-195 625.0
TLS2_k127_1245583_20 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 296.0
TLS2_k127_1245583_21 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 304.0
TLS2_k127_1245583_22 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 295.0
TLS2_k127_1245583_23 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000785 253.0
TLS2_k127_1245583_24 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000002491 258.0
TLS2_k127_1245583_25 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001106 252.0
TLS2_k127_1245583_26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000001232 243.0
TLS2_k127_1245583_27 Bacillithiol biosynthesis BshC K22136 - - 0.00000000000000000000000000000000000000000000000000000000000000238 238.0
TLS2_k127_1245583_28 Caudovirus prohead serine protease K06904 - - 0.000000000000000000000000000000000000000000000000000000001471 208.0
TLS2_k127_1245583_29 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000191 209.0
TLS2_k127_1245583_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000698 570.0
TLS2_k127_1245583_30 - - - - 0.00000000000000000000000000000000000000000000000000000004926 217.0
TLS2_k127_1245583_31 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000002633 194.0
TLS2_k127_1245583_32 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000001555 183.0
TLS2_k127_1245583_33 UvrB/uvrC motif K19411 - - 0.000000000000000000000000000000000000004269 151.0
TLS2_k127_1245583_34 phage terminase small subunit - - - 0.000000000000000000000000000000000000004796 147.0
TLS2_k127_1245583_35 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000000005575 164.0
TLS2_k127_1245583_36 epimerase - - - 0.0000000000000000000000000000000000008198 147.0
TLS2_k127_1245583_37 - - - - 0.0000000000000000000000000000000001089 142.0
TLS2_k127_1245583_38 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000001788 132.0
TLS2_k127_1245583_39 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000003108 123.0
TLS2_k127_1245583_4 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009347 566.0
TLS2_k127_1245583_40 - - - - 0.0000000000000000000000000002787 125.0
TLS2_k127_1245583_41 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism - - - 0.000000000000000000000000007176 122.0
TLS2_k127_1245583_42 Belongs to the UPF0434 family K09791 - - 0.000000000000000001259 85.0
TLS2_k127_1245583_44 Putative prokaryotic signal transducing protein - - - 0.00000002172 63.0
TLS2_k127_1245583_45 Outer membrane protein (OmpH-like) K06142 - - 0.000000512 58.0
TLS2_k127_1245583_5 Sodium:sulfate symporter transmembrane region K03319 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 528.0
TLS2_k127_1245583_6 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 514.0
TLS2_k127_1245583_7 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 505.0
TLS2_k127_1245583_8 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 483.0
TLS2_k127_1245583_9 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 440.0
TLS2_k127_1338036_0 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 314.0
TLS2_k127_1338036_1 Thioredoxin-like domain K03672 - 1.8.1.8 0.0000000000000000000000000000000004626 133.0
TLS2_k127_1338036_2 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000001848 56.0
TLS2_k127_1338036_3 - - - - 0.000007049 49.0
TLS2_k127_1338036_6 Bacterial Ig-like domain - - - 0.00001515 57.0
TLS2_k127_1338036_8 - - - - 0.00006513 47.0
TLS2_k127_1357862_0 DEAD DEAH box helicase K03724 - - 0.0 1547.0
TLS2_k127_1357862_1 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000007781 147.0
TLS2_k127_1357862_2 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.000000000000000003328 94.0
TLS2_k127_1357862_3 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.0000000000002211 82.0
TLS2_k127_1387627_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 7.483e-288 891.0
TLS2_k127_1387627_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 9.128e-268 841.0
TLS2_k127_1387627_10 Arginosuccinate synthase K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 524.0
TLS2_k127_1387627_11 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 524.0
TLS2_k127_1387627_12 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 523.0
TLS2_k127_1387627_13 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008701 492.0
TLS2_k127_1387627_14 Polysaccharide biosynthesis protein K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 484.0
TLS2_k127_1387627_15 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 456.0
TLS2_k127_1387627_16 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005259 439.0
TLS2_k127_1387627_17 Glycosyl transferase 4-like K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 418.0
TLS2_k127_1387627_18 Aminoacyl tRNA synthetase class II, N-terminal domain K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009686 410.0
TLS2_k127_1387627_19 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 417.0
TLS2_k127_1387627_2 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.268e-258 804.0
TLS2_k127_1387627_20 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 401.0
TLS2_k127_1387627_21 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 394.0
TLS2_k127_1387627_22 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 391.0
TLS2_k127_1387627_23 3-phosphoshikimate 1-carboxyvinyltransferase activity K00800 GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 381.0
TLS2_k127_1387627_24 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 352.0
TLS2_k127_1387627_25 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 357.0
TLS2_k127_1387627_26 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 353.0
TLS2_k127_1387627_27 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 344.0
TLS2_k127_1387627_28 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 342.0
TLS2_k127_1387627_29 Protein of unknown function (DUF1194) K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 333.0
TLS2_k127_1387627_3 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 5.01e-251 790.0
TLS2_k127_1387627_30 PFAM sodium calcium exchanger membrane region K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 327.0
TLS2_k127_1387627_31 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008293 321.0
TLS2_k127_1387627_32 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 302.0
TLS2_k127_1387627_33 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 297.0
TLS2_k127_1387627_34 cellular response to dsDNA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008601 274.0
TLS2_k127_1387627_35 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001249 262.0
TLS2_k127_1387627_36 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000001339 266.0
TLS2_k127_1387627_37 SecD/SecF GG Motif K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000001411 244.0
TLS2_k127_1387627_38 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000002765 246.0
TLS2_k127_1387627_39 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000007639 242.0
TLS2_k127_1387627_4 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 2.164e-241 762.0
TLS2_k127_1387627_40 von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000007739 254.0
TLS2_k127_1387627_41 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K00851,K00852,K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000001767 237.0
TLS2_k127_1387627_42 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000535 236.0
TLS2_k127_1387627_43 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000001045 226.0
TLS2_k127_1387627_44 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000007966 230.0
TLS2_k127_1387627_45 Domain of unknown function DUF21 - - - 0.00000000000000000000000000000000000000000000000000000000000000114 235.0
TLS2_k127_1387627_46 Metal-independent alpha-mannosidase (GH125) - - - 0.000000000000000000000000000000000000000000000000000000000000001804 241.0
TLS2_k127_1387627_47 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000008737 226.0
TLS2_k127_1387627_48 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000003321 222.0
TLS2_k127_1387627_49 Oxygen tolerance - - - 0.00000000000000000000000000000000000000000000000000000000118 227.0
TLS2_k127_1387627_5 B3/4 domain K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 624.0
TLS2_k127_1387627_50 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000001965 211.0
TLS2_k127_1387627_51 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000001117 186.0
TLS2_k127_1387627_52 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000003574 181.0
TLS2_k127_1387627_53 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000001377 144.0
TLS2_k127_1387627_54 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000002248 156.0
TLS2_k127_1387627_55 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000006319 150.0
TLS2_k127_1387627_56 Dual specificity phosphatase, catalytic domain - - - 0.0000000000000000000000000000000000006963 147.0
TLS2_k127_1387627_57 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000004175 133.0
TLS2_k127_1387627_58 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.0000000000000000000000000000000007985 137.0
TLS2_k127_1387627_59 Protein of unknown function (DUF3037) - - - 0.000000000000000000000000000000001036 134.0
TLS2_k127_1387627_6 Fructose-bisphosphate aldolase class K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008908 559.0
TLS2_k127_1387627_60 Regulates arginine biosynthesis genes K03402 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006355,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901605,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000437 127.0
TLS2_k127_1387627_61 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000004306 91.0
TLS2_k127_1387627_62 23S rRNA-intervening sequence protein - - - 0.0000000000000000009924 91.0
TLS2_k127_1387627_63 Ribosomal protein L35 K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000003766 78.0
TLS2_k127_1387627_64 Putative ATP-dependent Lon protease K01338 - 3.4.21.53 0.00000000000001117 76.0
TLS2_k127_1387627_65 rRNA binding K02968 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000006524 72.0
TLS2_k127_1387627_66 Psort location CytoplasmicMembrane, score - - - 0.00000000005475 74.0
TLS2_k127_1387627_67 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000004119 54.0
TLS2_k127_1387627_68 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000001716 55.0
TLS2_k127_1387627_69 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000001994 54.0
TLS2_k127_1387627_7 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006308 563.0
TLS2_k127_1387627_71 - - - - 0.00011 53.0
TLS2_k127_1387627_73 PFAM Extracellular ligand-binding receptor K01999 - - 0.0008829 51.0
TLS2_k127_1387627_8 CarboxypepD_reg-like domain K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 563.0
TLS2_k127_1387627_9 Biotin carboxylase C-terminal domain K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 531.0
TLS2_k127_1392817_0 Animal haem peroxidase - - - 0.0 1190.0
TLS2_k127_1392817_1 cytochrome C peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 550.0
TLS2_k127_1392817_10 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 312.0
TLS2_k127_1392817_11 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008624 301.0
TLS2_k127_1392817_12 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000008165 252.0
TLS2_k127_1392817_13 mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000004377 243.0
TLS2_k127_1392817_14 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000279 208.0
TLS2_k127_1392817_15 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000006783 214.0
TLS2_k127_1392817_16 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000001045 192.0
TLS2_k127_1392817_17 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000003486 179.0
TLS2_k127_1392817_18 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000003027 172.0
TLS2_k127_1392817_19 cytochrome C peroxidase - - - 0.0000000000000000000000000000000000001988 146.0
TLS2_k127_1392817_2 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 532.0
TLS2_k127_1392817_20 Thioredoxin-like - - - 0.0000000000000000000000000501 121.0
TLS2_k127_1392817_21 YtxH-like protein - - - 0.0000000000000000000002408 102.0
TLS2_k127_1392817_22 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000001172 82.0
TLS2_k127_1392817_23 PAS domain - - - 0.0000000001613 71.0
TLS2_k127_1392817_24 - - - - 0.000000008309 64.0
TLS2_k127_1392817_3 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 497.0
TLS2_k127_1392817_4 cytochrome C peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008879 476.0
TLS2_k127_1392817_5 DALR_2 K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 475.0
TLS2_k127_1392817_6 Phosphoglucose isomerase K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 435.0
TLS2_k127_1392817_7 PFAM Amidohydrolase 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006056 348.0
TLS2_k127_1392817_8 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 334.0
TLS2_k127_1392817_9 cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 323.0
TLS2_k127_141954_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 3.438e-317 1005.0
TLS2_k127_141954_1 Alpha-glucan phosphorylase K00688 - 2.4.1.1 2.164e-221 709.0
TLS2_k127_141954_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009052 497.0
TLS2_k127_141954_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005428 473.0
TLS2_k127_141954_4 Transposase, Mutator family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 315.0
TLS2_k127_141954_5 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000007808 225.0
TLS2_k127_141954_6 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000002874 193.0
TLS2_k127_141954_7 Transposase K07493 - - 0.000000000654 62.0
TLS2_k127_142273_0 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 1.273e-284 898.0
TLS2_k127_142273_1 ABC transporter transmembrane region K11085 - - 4.734e-222 704.0
TLS2_k127_142273_10 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000005329 278.0
TLS2_k127_142273_11 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009372 288.0
TLS2_k127_142273_12 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000766 263.0
TLS2_k127_142273_13 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002868 260.0
TLS2_k127_142273_14 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000865 240.0
TLS2_k127_142273_15 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000004008 247.0
TLS2_k127_142273_16 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000402 219.0
TLS2_k127_142273_17 - - - - 0.000000000000000000000000000000000000000000000000000005181 198.0
TLS2_k127_142273_18 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000008649 195.0
TLS2_k127_142273_19 Disulphide isomerase - - - 0.0000000000000000000000000000000000000001228 156.0
TLS2_k127_142273_2 Histidine kinase K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 486.0
TLS2_k127_142273_20 PFAM CheW domain protein K03408 - - 0.00000000000000000000000000004708 123.0
TLS2_k127_142273_21 PAS domain - - - 0.000000000000000000000000008802 128.0
TLS2_k127_142273_22 Two component signalling adaptor domain - - - 0.00000000000000000001048 99.0
TLS2_k127_142273_23 PFAM transposase mutator type - - - 0.00000001712 57.0
TLS2_k127_142273_24 phosphinothricin N-acetyltransferase activity K03823 - 2.3.1.183 0.000009277 57.0
TLS2_k127_142273_3 transmembrane signaling receptor activity K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 357.0
TLS2_k127_142273_4 Integral membrane protein TerC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 335.0
TLS2_k127_142273_5 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 341.0
TLS2_k127_142273_6 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 340.0
TLS2_k127_142273_7 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 319.0
TLS2_k127_142273_8 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 319.0
TLS2_k127_142273_9 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 314.0
TLS2_k127_1425809_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1091.0
TLS2_k127_1425809_1 Putative aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002321 291.0
TLS2_k127_1425809_2 PhoQ Sensor - - - 0.0000000000000000000000000000000000001421 163.0
TLS2_k127_1425809_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000005859 108.0
TLS2_k127_1425809_4 Belongs to the UPF0337 (CsbD) family - - - 0.0007132 48.0
TLS2_k127_15291_0 glucose sorbosone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 575.0
TLS2_k127_15291_1 imidazolonepropionase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009905 352.0
TLS2_k127_15291_10 Domain of unknown function (DUF4440) - - - 0.0000005486 57.0
TLS2_k127_15291_11 Protein tyrosine kinase K12132 - 2.7.11.1 0.0001942 49.0
TLS2_k127_15291_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000302 293.0
TLS2_k127_15291_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000009708 253.0
TLS2_k127_15291_4 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000003522 235.0
TLS2_k127_15291_5 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000001711 231.0
TLS2_k127_15291_6 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000003517 247.0
TLS2_k127_15291_7 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000003063 193.0
TLS2_k127_15291_8 COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog - - - 0.00000000000000000000000000000000000002541 150.0
TLS2_k127_15291_9 - - - - 0.00000000009544 70.0
TLS2_k127_1636190_0 Peptidase family M1 domain - - - 1.614e-244 773.0
TLS2_k127_1636190_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 1.053e-202 672.0
TLS2_k127_1636190_10 PFAM cytochrome bd ubiquinol oxidase subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 405.0
TLS2_k127_1636190_11 serine-type peptidase activity K01278 - 3.4.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 387.0
TLS2_k127_1636190_12 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 366.0
TLS2_k127_1636190_13 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006623 319.0
TLS2_k127_1636190_14 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 306.0
TLS2_k127_1636190_15 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003828 274.0
TLS2_k127_1636190_16 Type III restriction enzyme res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001028 263.0
TLS2_k127_1636190_18 Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) K07337,K21008 GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000004851 237.0
TLS2_k127_1636190_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000001833 226.0
TLS2_k127_1636190_2 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 578.0
TLS2_k127_1636190_20 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000000001647 211.0
TLS2_k127_1636190_21 - - - - 0.000000000000000000000000000000000000000000000000000000001444 205.0
TLS2_k127_1636190_22 - - - - 0.00000000000000000000000000000000000000000000000000000001482 205.0
TLS2_k127_1636190_23 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000001671 196.0
TLS2_k127_1636190_24 Nucleotidyl transferase K00966,K00973 - 2.7.7.13,2.7.7.24 0.000000000000000000000000000000000000000000000000005454 195.0
TLS2_k127_1636190_25 Protein of unknown function (DUF520) K09767 - - 0.00000000000000000000000000000000000000000000000001222 192.0
TLS2_k127_1636190_26 ECF sigma factor - - - 0.00000000000000000000000000000000000000000002261 170.0
TLS2_k127_1636190_27 Protein of unknown function (DUF1572) - - - 0.000000000000000000000000000000000000000005974 160.0
TLS2_k127_1636190_28 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000002191 163.0
TLS2_k127_1636190_29 ECF sigma factor K03088 - - 0.0000000000000000000000000000000003694 140.0
TLS2_k127_1636190_3 PFAM cytochrome bd ubiquinol oxidase subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 551.0
TLS2_k127_1636190_30 COGs COG3372 conserved K09744 - - 0.000000000000000000000000000000001034 145.0
TLS2_k127_1636190_31 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000001249 131.0
TLS2_k127_1636190_32 Protein conserved in bacteria - - - 0.0000000000000000000000000000003986 128.0
TLS2_k127_1636190_33 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000001528 116.0
TLS2_k127_1636190_34 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000001704 95.0
TLS2_k127_1636190_35 PIN domain - - - 0.00000000000000001334 91.0
TLS2_k127_1636190_36 - - - - 0.00000000000001635 88.0
TLS2_k127_1636190_37 Protein conserved in bacteria K09859 - - 0.00000000000006077 85.0
TLS2_k127_1636190_38 impB/mucB/samB family - - - 0.000000007968 68.0
TLS2_k127_1636190_39 - - - - 0.0000000118 59.0
TLS2_k127_1636190_4 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 502.0
TLS2_k127_1636190_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 482.0
TLS2_k127_1636190_6 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 506.0
TLS2_k127_1636190_7 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 432.0
TLS2_k127_1636190_8 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 432.0
TLS2_k127_1636190_9 PFAM ATP dependent DNA ligase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 406.0
TLS2_k127_1743234_0 PFAM transposase IS116 IS110 IS902 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 327.0
TLS2_k127_1743234_1 Transposase - - - 0.00000000000005213 76.0
TLS2_k127_1743234_2 COG3335 Transposase and inactivated derivatives - - - 0.00002976 46.0
TLS2_k127_1775026_0 Subunit R is required for both nuclease and ATPase activities, but not for modification - - - 0.0 1571.0
TLS2_k127_1775026_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K22015 - 1.17.1.9,1.17.99.7 0.0 1256.0
TLS2_k127_1775026_10 Glycosyl transferase family 21 K00694 - 2.4.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004627 540.0
TLS2_k127_1775026_11 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 550.0
TLS2_k127_1775026_12 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 529.0
TLS2_k127_1775026_13 COG1226 Kef-type K transport systems - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004516 514.0
TLS2_k127_1775026_14 PFAM Stem cell self-renewal protein Piwi - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 498.0
TLS2_k127_1775026_15 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 472.0
TLS2_k127_1775026_16 ABC transporter K02021,K06147,K06148,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008802 477.0
TLS2_k127_1775026_17 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 472.0
TLS2_k127_1775026_18 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 465.0
TLS2_k127_1775026_19 Anticodon nuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 456.0
TLS2_k127_1775026_2 Type I restriction-modification system methyltransferase subunit K03427 - 2.1.1.72 4.829e-294 908.0
TLS2_k127_1775026_20 FIST C domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000619 439.0
TLS2_k127_1775026_21 SIR2-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005181 447.0
TLS2_k127_1775026_22 PFAM ABC-3 protein K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 433.0
TLS2_k127_1775026_23 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 408.0
TLS2_k127_1775026_24 ABC 3 transport family K11708 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 402.0
TLS2_k127_1775026_25 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843,K02849,K12982 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 382.0
TLS2_k127_1775026_26 PFAM ABC transporter related K11710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 380.0
TLS2_k127_1775026_27 Belongs to the glycosyl hydrolase 26 family K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 378.0
TLS2_k127_1775026_28 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 393.0
TLS2_k127_1775026_29 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 357.0
TLS2_k127_1775026_3 Zinc carboxypeptidase - - - 7.046e-233 756.0
TLS2_k127_1775026_30 Glycosyltransferase family 9 (heptosyltransferase) K12982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 344.0
TLS2_k127_1775026_31 Type I restriction modification DNA specificity domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 348.0
TLS2_k127_1775026_32 Belongs to the bacterial solute-binding protein 9 family K11707 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 339.0
TLS2_k127_1775026_33 MatE K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008582 303.0
TLS2_k127_1775026_34 Serine dehydratase alpha chain K01752 - 4.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007194 285.0
TLS2_k127_1775026_35 Serine dehydratase beta chain K01752 - 4.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000002708 260.0
TLS2_k127_1775026_36 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000001734 246.0
TLS2_k127_1775026_37 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000003709 252.0
TLS2_k127_1775026_38 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003908 243.0
TLS2_k127_1775026_39 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000000001227 236.0
TLS2_k127_1775026_4 Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00122 - 1.17.1.9 5.566e-221 705.0
TLS2_k127_1775026_40 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000001889 229.0
TLS2_k127_1775026_41 - - - - 0.00000000000000000000000000000000000000000000000000000000000000007884 235.0
TLS2_k127_1775026_42 HD domain - - - 0.000000000000000000000000000000000000000000000000000000001368 218.0
TLS2_k127_1775026_43 Glycosyl transferase family 2 K08301 - - 0.0000000000000000000000000000000000000000000000000002362 205.0
TLS2_k127_1775026_44 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000001059 197.0
TLS2_k127_1775026_45 TIGRFAM M6 family metalloprotease domain - - - 0.00000000000000000000000000000000000000000000000008329 203.0
TLS2_k127_1775026_46 - - - - 0.0000000000000000000000000000000000000000000005746 188.0
TLS2_k127_1775026_47 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000006833 174.0
TLS2_k127_1775026_48 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000000002878 157.0
TLS2_k127_1775026_49 Methyltransferase domain - - - 0.00000000000000000000000000000002609 136.0
TLS2_k127_1775026_5 Peptidase family M28 - - - 9.335e-211 676.0
TLS2_k127_1775026_50 PFAM Peptidase family M23 - - - 0.0000000000000000000000000000003357 135.0
TLS2_k127_1775026_51 RF-1 domain K15034 - - 0.0000000000000000000000000005352 123.0
TLS2_k127_1775026_52 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000633 96.0
TLS2_k127_1775026_55 COGs COG3328 Transposase and inactivated derivatives - - - 0.000000000001243 70.0
TLS2_k127_1775026_56 kinase activity K02527,K11211 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15,2.7.1.166 0.0000000001205 72.0
TLS2_k127_1775026_57 Transposase - - - 0.00000001499 61.0
TLS2_k127_1775026_58 Transposase - - - 0.000001407 53.0
TLS2_k127_1775026_59 - - - - 0.000003662 58.0
TLS2_k127_1775026_6 efflux transmembrane transporter activity - - - 1.324e-205 667.0
TLS2_k127_1775026_60 DNA methylase K00590 - 2.1.1.113 0.00004319 48.0
TLS2_k127_1775026_61 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0005362 51.0
TLS2_k127_1775026_7 Bacterial protein of unknown function (DUF885) - - - 3.468e-199 642.0
TLS2_k127_1775026_8 Belongs to the citrate synthase family K01647 - 2.3.3.1 5.249e-194 617.0
TLS2_k127_1775026_9 PglZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 549.0
TLS2_k127_1823376_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1266.0
TLS2_k127_1823376_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 543.0
TLS2_k127_1823376_10 Thioredoxin-like - - - 0.00000000000000000000000000000005397 141.0
TLS2_k127_1823376_11 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.00000000000000000000000001139 118.0
TLS2_k127_1823376_12 Outer membrane protein beta-barrel domain - - - 0.000000000000000749 84.0
TLS2_k127_1823376_13 HEAT repeats - - - 0.0000000000000007633 90.0
TLS2_k127_1823376_14 Flavin reductase like domain - - - 0.00000000000000195 84.0
TLS2_k127_1823376_15 PFAM Cellulose synthase operon K20543 - - 0.000003216 60.0
TLS2_k127_1823376_2 Glycosyl transferase family 21 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 523.0
TLS2_k127_1823376_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 487.0
TLS2_k127_1823376_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 436.0
TLS2_k127_1823376_5 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008507 387.0
TLS2_k127_1823376_6 Evidence 2b Function of strongly homologous gene K01990,K09689,K09691 - 3.6.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 299.0
TLS2_k127_1823376_7 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 318.0
TLS2_k127_1823376_8 ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 295.0
TLS2_k127_1823376_9 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000005455 201.0
TLS2_k127_2001278_0 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000002382 251.0
TLS2_k127_2001278_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000005385 108.0
TLS2_k127_2040489_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1066.0
TLS2_k127_2040489_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 8.859e-297 925.0
TLS2_k127_2040489_10 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 359.0
TLS2_k127_2040489_11 peptidase dimerisation domain protein K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 336.0
TLS2_k127_2040489_12 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 310.0
TLS2_k127_2040489_13 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 301.0
TLS2_k127_2040489_14 Anhydro-N-acetylmuramic acid kinase K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 304.0
TLS2_k127_2040489_15 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001962 258.0
TLS2_k127_2040489_16 Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000005304 261.0
TLS2_k127_2040489_17 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000184 231.0
TLS2_k127_2040489_18 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000008765 192.0
TLS2_k127_2040489_19 PHP-associated - - - 0.000000000000000000000000000000000000000000000007269 180.0
TLS2_k127_2040489_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 1.871e-248 781.0
TLS2_k127_2040489_20 Protein of unknown function (DUF3299) K09950 - - 0.0000000000000000000000000000000000000004616 155.0
TLS2_k127_2040489_21 Fibronectin fibrinogen-binding protein - - - 0.000000000000000000000000000000000002239 141.0
TLS2_k127_2040489_22 Ferric uptake regulator family K03711 - - 0.000000000000000000000000000000000002865 143.0
TLS2_k127_2040489_23 - - - - 0.000000000000000000000000006398 121.0
TLS2_k127_2040489_24 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000002348 126.0
TLS2_k127_2040489_25 COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family K00484 - 1.5.1.36 0.00000000000000000000009216 104.0
TLS2_k127_2040489_26 - - - - 0.0000000000000000000001665 99.0
TLS2_k127_2040489_27 SNARE associated Golgi protein - - - 0.00000000000000000003769 103.0
TLS2_k127_2040489_28 response regulator K07667 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000001423 85.0
TLS2_k127_2040489_29 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000001746 62.0
TLS2_k127_2040489_3 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 589.0
TLS2_k127_2040489_30 Thioredoxin-like K03671 - - 0.0005621 42.0
TLS2_k127_2040489_4 ABC transporter transmembrane region K18889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 565.0
TLS2_k127_2040489_5 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 492.0
TLS2_k127_2040489_6 HI0933-like protein K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 467.0
TLS2_k127_2040489_7 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 439.0
TLS2_k127_2040489_8 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009228 399.0
TLS2_k127_2040489_9 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008124 385.0
TLS2_k127_2077766_0 COG2303 Choline dehydrogenase and related flavoproteins K06151 - 1.1.99.3 2.279e-216 684.0
TLS2_k127_2077766_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 2.894e-211 679.0
TLS2_k127_2077766_10 ATP-binding region, ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 404.0
TLS2_k127_2077766_11 COG1228 Imidazolonepropionase and related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000718 391.0
TLS2_k127_2077766_12 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 383.0
TLS2_k127_2077766_13 amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 336.0
TLS2_k127_2077766_14 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 331.0
TLS2_k127_2077766_15 PFAM Amino acid permease K03294,K13868 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007973 316.0
TLS2_k127_2077766_16 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 299.0
TLS2_k127_2077766_17 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005416 273.0
TLS2_k127_2077766_18 Domain of unknown function (DUF1949) - - - 0.00000000000000000000000000000000000000000000000000000000000007814 223.0
TLS2_k127_2077766_19 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000113 211.0
TLS2_k127_2077766_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 576.0
TLS2_k127_2077766_20 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000109 138.0
TLS2_k127_2077766_21 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000002447 139.0
TLS2_k127_2077766_22 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000495 143.0
TLS2_k127_2077766_23 nucleotidyltransferase activity K07075 - - 0.0000000000000000000000000001096 117.0
TLS2_k127_2077766_25 phosphorelay signal transduction system - - - 0.00000000000000005619 92.0
TLS2_k127_2077766_27 PFAM CBS domain containing protein - - - 0.0000000002792 69.0
TLS2_k127_2077766_28 Peptidoglycan-binding domain 1 protein - - - 0.000000004088 63.0
TLS2_k127_2077766_29 protein kinase activity K12132 - 2.7.11.1 0.000001965 60.0
TLS2_k127_2077766_3 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 583.0
TLS2_k127_2077766_30 AAA ATPase domain - - - 0.00001909 53.0
TLS2_k127_2077766_31 eRF1 domain 3 - - - 0.0003978 48.0
TLS2_k127_2077766_4 Glycine D-amino acid oxidase (deaminating) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 544.0
TLS2_k127_2077766_5 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 562.0
TLS2_k127_2077766_6 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 523.0
TLS2_k127_2077766_7 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005594 518.0
TLS2_k127_2077766_8 HupE / UreJ protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 464.0
TLS2_k127_2077766_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007842 412.0
TLS2_k127_2082109_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 541.0
TLS2_k127_2082109_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 407.0
TLS2_k127_2082109_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007402 342.0
TLS2_k127_2082109_3 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.000000000000000000000000000000000000000000000000000000002735 203.0
TLS2_k127_2082109_4 homoserine kinase activity K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.000000000000000000000000000000000000000000000001072 187.0
TLS2_k127_2082109_5 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000005123 141.0
TLS2_k127_2082109_6 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000001289 128.0
TLS2_k127_2082109_7 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0008264 43.0
TLS2_k127_2115718_0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 6.81e-271 848.0
TLS2_k127_2115718_1 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 6.512e-223 703.0
TLS2_k127_2115718_10 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002002 281.0
TLS2_k127_2115718_11 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000191 256.0
TLS2_k127_2115718_12 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001696 259.0
TLS2_k127_2115718_13 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000009743 251.0
TLS2_k127_2115718_14 ABC-type tungstate transport system permease component-like protein K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000003221 236.0
TLS2_k127_2115718_15 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000005141 235.0
TLS2_k127_2115718_16 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000003304 218.0
TLS2_k127_2115718_17 domain, Protein K01179,K07260,K13735 - 3.2.1.4,3.4.17.14 0.00000000000000000000000000000000000000000000000000000000001107 232.0
TLS2_k127_2115718_18 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000001091 215.0
TLS2_k127_2115718_19 Beta-lactamase K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000003539 224.0
TLS2_k127_2115718_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 631.0
TLS2_k127_2115718_20 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000001592 201.0
TLS2_k127_2115718_21 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000000002031 192.0
TLS2_k127_2115718_22 Zn peptidase - - - 0.000000000000000000000000000000000000000000000000007053 197.0
TLS2_k127_2115718_23 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000004303 184.0
TLS2_k127_2115718_24 BadF/BadG/BcrA/BcrD ATPase family K18676 - 2.7.1.8 0.00000000000000000000000000000000000000002054 164.0
TLS2_k127_2115718_25 - - - - 0.00000000000000000000000000000000000000004232 159.0
TLS2_k127_2115718_26 response regulator K22010 - - 0.0000000000000000000000000000000000000003197 164.0
TLS2_k127_2115718_27 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000003723 148.0
TLS2_k127_2115718_28 NlpC/P60 family - - - 0.0000000000000000000000000000000001236 147.0
TLS2_k127_2115718_29 PFAM Phosphoglycerate mutase - - - 0.000000000000000000000000000000001936 137.0
TLS2_k127_2115718_3 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007377 563.0
TLS2_k127_2115718_30 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000001196 108.0
TLS2_k127_2115718_32 TIGRFAM Molybdopterin-guanine dinucleotide biosynthesis protein B K03753,K13818 - 2.7.7.77 0.000000000000000007825 92.0
TLS2_k127_2115718_33 response regulator, receiver - - - 0.000000000000193 72.0
TLS2_k127_2115718_34 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000002803 79.0
TLS2_k127_2115718_35 - - - - 0.000000001165 68.0
TLS2_k127_2115718_36 Peptidase_C39 like family - - - 0.00003735 57.0
TLS2_k127_2115718_4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 424.0
TLS2_k127_2115718_5 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 422.0
TLS2_k127_2115718_6 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 386.0
TLS2_k127_2115718_7 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 345.0
TLS2_k127_2115718_8 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 320.0
TLS2_k127_2115718_9 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 312.0
TLS2_k127_2147264_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1357.0
TLS2_k127_2147264_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1171.0
TLS2_k127_2147264_10 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 5.856e-246 778.0
TLS2_k127_2147264_100 O-acyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000018 282.0
TLS2_k127_2147264_101 Sugar nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004576 290.0
TLS2_k127_2147264_102 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000876 287.0
TLS2_k127_2147264_103 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004739 278.0
TLS2_k127_2147264_104 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008474 278.0
TLS2_k127_2147264_105 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000023 279.0
TLS2_k127_2147264_106 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007092 272.0
TLS2_k127_2147264_107 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000002481 270.0
TLS2_k127_2147264_108 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004798 274.0
TLS2_k127_2147264_109 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002602 259.0
TLS2_k127_2147264_11 Aldehyde dehydrogenase family K22187 - - 3.868e-245 766.0
TLS2_k127_2147264_110 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002978 257.0
TLS2_k127_2147264_111 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007031 269.0
TLS2_k127_2147264_112 Lytic transglycosylase catalytic K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007396 268.0
TLS2_k127_2147264_113 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000001927 251.0
TLS2_k127_2147264_114 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000985 254.0
TLS2_k127_2147264_115 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000773 246.0
TLS2_k127_2147264_116 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000106 239.0
TLS2_k127_2147264_117 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000003297 237.0
TLS2_k127_2147264_118 bacterial-type flagellum-dependent cell motility K01317 - 3.4.21.10 0.0000000000000000000000000000000000000000000000000000000000000000003303 254.0
TLS2_k127_2147264_119 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000005646 236.0
TLS2_k127_2147264_12 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.318e-239 761.0
TLS2_k127_2147264_120 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000007647 241.0
TLS2_k127_2147264_121 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000002201 230.0
TLS2_k127_2147264_122 GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000000000000000000000000002368 233.0
TLS2_k127_2147264_123 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000003043 242.0
TLS2_k127_2147264_124 Part of the ABC transporter FtsEX involved in K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000489 226.0
TLS2_k127_2147264_125 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000004061 241.0
TLS2_k127_2147264_126 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000002493 225.0
TLS2_k127_2147264_127 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000002433 211.0
TLS2_k127_2147264_128 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000005422 208.0
TLS2_k127_2147264_129 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000001076 221.0
TLS2_k127_2147264_13 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.106e-234 751.0
TLS2_k127_2147264_130 GGDEF domain K11527 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000002429 216.0
TLS2_k127_2147264_131 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000811 207.0
TLS2_k127_2147264_132 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000000001247 211.0
TLS2_k127_2147264_133 creatininase K01470,K22232 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000003802 207.0
TLS2_k127_2147264_134 Peptidase, M28 - - - 0.00000000000000000000000000000000000000000000000000000001646 219.0
TLS2_k127_2147264_135 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000002245 215.0
TLS2_k127_2147264_136 SIS domain K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000002597 199.0
TLS2_k127_2147264_137 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000001153 196.0
TLS2_k127_2147264_138 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000002187 199.0
TLS2_k127_2147264_139 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000003005 195.0
TLS2_k127_2147264_14 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.738e-234 766.0
TLS2_k127_2147264_140 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000002169 185.0
TLS2_k127_2147264_141 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000004361 194.0
TLS2_k127_2147264_142 Alpha beta hydrolase fold protein - - - 0.000000000000000000000000000000000000000000000000168 188.0
TLS2_k127_2147264_143 ZIP Zinc transporter K07238,K11021,K16267 - - 0.000000000000000000000000000000000000000000000001527 183.0
TLS2_k127_2147264_144 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000007143 175.0
TLS2_k127_2147264_145 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000009535 170.0
TLS2_k127_2147264_146 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000001005 171.0
TLS2_k127_2147264_147 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000133 178.0
TLS2_k127_2147264_148 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000003062 171.0
TLS2_k127_2147264_149 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000003501 175.0
TLS2_k127_2147264_15 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K16881 - 2.7.7.13,5.4.2.8 3.043e-231 743.0
TLS2_k127_2147264_150 membrane K11622 - - 0.000000000000000000000000000000000000000000004872 176.0
TLS2_k127_2147264_151 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000004773 168.0
TLS2_k127_2147264_152 response regulator K22010 - - 0.0000000000000000000000000000000000000000001083 166.0
TLS2_k127_2147264_153 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000001753 164.0
TLS2_k127_2147264_154 Thioredoxin-like domain K03671 - - 0.00000000000000000000000000000000000000001296 155.0
TLS2_k127_2147264_155 rod shape-determining protein MreC K03570 - - 0.00000000000000000000000000000000000000007731 162.0
TLS2_k127_2147264_156 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000002806 153.0
TLS2_k127_2147264_157 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000000000000000000000001255 151.0
TLS2_k127_2147264_158 Rossmann-like domain - - - 0.00000000000000000000000000000000000001286 155.0
TLS2_k127_2147264_159 Binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000004609 154.0
TLS2_k127_2147264_16 Involved in the tonB-independent uptake of proteins - - - 1.479e-224 736.0
TLS2_k127_2147264_160 Ferric uptake regulator family K09825 - - 0.00000000000000000000000000000000003453 140.0
TLS2_k127_2147264_161 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000003387 134.0
TLS2_k127_2147264_162 COGs COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) K07259 - 3.4.16.4 0.000000000000000000000000000000008563 139.0
TLS2_k127_2147264_163 Histidine kinase K07679,K07716 - 2.7.13.3 0.00000000000000000000000000000001099 141.0
TLS2_k127_2147264_164 - - - - 0.00000000000000000000000000000009649 132.0
TLS2_k127_2147264_165 PPIC-type PPIASE domain K03770 - 5.2.1.8 0.0000000000000000000000000000001208 141.0
TLS2_k127_2147264_166 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759,K05606 - 4.4.1.5,5.1.99.1 0.0000000000000000000000000000001463 128.0
TLS2_k127_2147264_167 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000000000000000001613 135.0
TLS2_k127_2147264_168 Transglycosylase SLT domain - - - 0.0000000000000000000000000000005571 135.0
TLS2_k127_2147264_169 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000008083 130.0
TLS2_k127_2147264_17 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 1.243e-218 697.0
TLS2_k127_2147264_170 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000001019 126.0
TLS2_k127_2147264_171 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000006516 120.0
TLS2_k127_2147264_172 translation release factor activity K03265 - - 0.000000000000000000000000002662 125.0
TLS2_k127_2147264_173 Belongs to the P(II) protein family - - - 0.00000000000000000000000002016 113.0
TLS2_k127_2147264_174 Domain of unknown function (DUF2383) - - - 0.00000000000000000000000004427 118.0
TLS2_k127_2147264_175 PPIC-type PPIASE domain K03769,K03771,K07533 - 5.2.1.8 0.00000000000000000000000005516 122.0
TLS2_k127_2147264_176 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000005865 110.0
TLS2_k127_2147264_177 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000002181 109.0
TLS2_k127_2147264_178 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000002578 115.0
TLS2_k127_2147264_179 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.0000000000000000000000003597 116.0
TLS2_k127_2147264_18 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 9.567e-213 673.0
TLS2_k127_2147264_181 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000000792 110.0
TLS2_k127_2147264_182 - - - - 0.0000000000000000000000007951 113.0
TLS2_k127_2147264_183 Uncharacterised protein family UPF0102 K07460 - - 0.000000000000000000000003009 107.0
TLS2_k127_2147264_184 Roadblock/LC7 domain - - - 0.000000000000000000000003786 113.0
TLS2_k127_2147264_185 Glycosyltransferase like family 2 - - - 0.00000000000000000000002922 100.0
TLS2_k127_2147264_186 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000008567 99.0
TLS2_k127_2147264_187 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000000000000000271 98.0
TLS2_k127_2147264_188 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000304 104.0
TLS2_k127_2147264_189 NifU-like domain - - - 0.000000000000000000009335 94.0
TLS2_k127_2147264_19 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 9.124e-208 677.0
TLS2_k127_2147264_190 Late embryogenesis abundant protein - - - 0.00000000000000000001318 97.0
TLS2_k127_2147264_191 Protein of unknown function (DUF1232) - - - 0.0000000000000000002057 94.0
TLS2_k127_2147264_192 - - - - 0.0000000000000001243 91.0
TLS2_k127_2147264_193 - - - - 0.000000000000001709 88.0
TLS2_k127_2147264_194 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000025 83.0
TLS2_k127_2147264_195 protein conserved in bacteria K09764 - - 0.00000000000000811 79.0
TLS2_k127_2147264_196 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000001213 82.0
TLS2_k127_2147264_197 Glycosyltransferase like family 2 - - - 0.0000000000002174 75.0
TLS2_k127_2147264_198 OsmC-like protein - - - 0.0000000000013 70.0
TLS2_k127_2147264_199 - - - - 0.00000000001273 70.0
TLS2_k127_2147264_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 7.505e-315 975.0
TLS2_k127_2147264_20 Alpha amylase, catalytic domain K06044 - 5.4.99.15 1.812e-205 668.0
TLS2_k127_2147264_200 50S ribosomal protein L7 - - - 0.0000000000371 69.0
TLS2_k127_2147264_201 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000005586 67.0
TLS2_k127_2147264_202 - - - - 0.000000000059 72.0
TLS2_k127_2147264_204 - - - - 0.000000001699 68.0
TLS2_k127_2147264_205 nuclear chromosome segregation - - - 0.000000003847 71.0
TLS2_k127_2147264_206 rod shape-determining protein MreD K03571 - - 0.00000001204 63.0
TLS2_k127_2147264_207 Lipoprotein K05811 - - 0.000001061 57.0
TLS2_k127_2147264_208 - - - - 0.000002491 55.0
TLS2_k127_2147264_209 Polymer-forming cytoskeletal - - - 0.000003382 59.0
TLS2_k127_2147264_21 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 6.082e-205 649.0
TLS2_k127_2147264_210 - - - - 0.00002057 55.0
TLS2_k127_2147264_211 amine dehydrogenase activity K01406 - 3.4.24.40 0.00007104 56.0
TLS2_k127_2147264_212 PFAM Sporulation domain protein - - - 0.00008888 55.0
TLS2_k127_2147264_213 - - - - 0.0003313 51.0
TLS2_k127_2147264_22 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000866 616.0
TLS2_k127_2147264_23 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 607.0
TLS2_k127_2147264_24 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 604.0
TLS2_k127_2147264_25 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700,K01236 - 2.4.1.18,3.2.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 614.0
TLS2_k127_2147264_26 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 631.0
TLS2_k127_2147264_27 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 590.0
TLS2_k127_2147264_28 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 576.0
TLS2_k127_2147264_29 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006891 564.0
TLS2_k127_2147264_3 glutamine synthetase K01915 - 6.3.1.2 1.164e-306 957.0
TLS2_k127_2147264_30 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004516 572.0
TLS2_k127_2147264_31 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 553.0
TLS2_k127_2147264_32 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 545.0
TLS2_k127_2147264_33 Hsp70 protein K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 541.0
TLS2_k127_2147264_34 Magnesium chelatase, subunit ChlI K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 548.0
TLS2_k127_2147264_35 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 542.0
TLS2_k127_2147264_36 Xaa-Pro aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006357 527.0
TLS2_k127_2147264_37 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 522.0
TLS2_k127_2147264_38 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009689 520.0
TLS2_k127_2147264_39 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 520.0
TLS2_k127_2147264_4 Belongs to the glycosyl hydrolase 57 family - - - 1.704e-300 941.0
TLS2_k127_2147264_40 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 531.0
TLS2_k127_2147264_41 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 490.0
TLS2_k127_2147264_42 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 484.0
TLS2_k127_2147264_43 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007861 480.0
TLS2_k127_2147264_44 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 477.0
TLS2_k127_2147264_45 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 483.0
TLS2_k127_2147264_46 PFAM Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 485.0
TLS2_k127_2147264_47 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 469.0
TLS2_k127_2147264_48 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 473.0
TLS2_k127_2147264_49 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008464 450.0
TLS2_k127_2147264_5 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 2.315e-289 903.0
TLS2_k127_2147264_50 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 450.0
TLS2_k127_2147264_51 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 442.0
TLS2_k127_2147264_52 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 437.0
TLS2_k127_2147264_53 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000592 432.0
TLS2_k127_2147264_54 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 437.0
TLS2_k127_2147264_55 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 445.0
TLS2_k127_2147264_56 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006727 435.0
TLS2_k127_2147264_57 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 431.0
TLS2_k127_2147264_58 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 426.0
TLS2_k127_2147264_59 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 429.0
TLS2_k127_2147264_6 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 5.34e-284 893.0
TLS2_k127_2147264_60 Conserved carboxylase domain K01960 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 429.0
TLS2_k127_2147264_61 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 405.0
TLS2_k127_2147264_62 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 404.0
TLS2_k127_2147264_63 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 398.0
TLS2_k127_2147264_64 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 403.0
TLS2_k127_2147264_65 GIY-YIG type nucleases (URI domain) K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 398.0
TLS2_k127_2147264_66 TIGRFAM sodium ion-translocating decarboxylase, beta subunit K01572 - 4.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 396.0
TLS2_k127_2147264_67 photoreceptor activity K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 396.0
TLS2_k127_2147264_68 Cell cycle protein K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 391.0
TLS2_k127_2147264_69 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 360.0
TLS2_k127_2147264_7 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 5.094e-265 833.0
TLS2_k127_2147264_70 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 364.0
TLS2_k127_2147264_71 Competence-damaged protein K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 359.0
TLS2_k127_2147264_72 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 347.0
TLS2_k127_2147264_73 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 348.0
TLS2_k127_2147264_74 Aminotransferase class-V K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 344.0
TLS2_k127_2147264_75 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 333.0
TLS2_k127_2147264_76 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 338.0
TLS2_k127_2147264_77 Ribosomal protein S2 K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 333.0
TLS2_k127_2147264_78 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 336.0
TLS2_k127_2147264_79 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 323.0
TLS2_k127_2147264_8 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 3.549e-254 819.0
TLS2_k127_2147264_80 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 315.0
TLS2_k127_2147264_81 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 317.0
TLS2_k127_2147264_82 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 320.0
TLS2_k127_2147264_83 Nucleotidyl transferase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007145 314.0
TLS2_k127_2147264_84 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 315.0
TLS2_k127_2147264_85 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 306.0
TLS2_k127_2147264_86 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 298.0
TLS2_k127_2147264_87 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 302.0
TLS2_k127_2147264_88 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 329.0
TLS2_k127_2147264_89 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000754 311.0
TLS2_k127_2147264_9 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 3.256e-247 782.0
TLS2_k127_2147264_90 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000806 305.0
TLS2_k127_2147264_91 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 296.0
TLS2_k127_2147264_92 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 299.0
TLS2_k127_2147264_93 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 295.0
TLS2_k127_2147264_94 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 297.0
TLS2_k127_2147264_95 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 306.0
TLS2_k127_2147264_96 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 295.0
TLS2_k127_2147264_97 ABC transporter K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 286.0
TLS2_k127_2147264_98 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000627 289.0
TLS2_k127_2147264_99 Peptidase M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001749 285.0
TLS2_k127_2191677_0 S-(hydroxymethyl)glutathione dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 416.0
TLS2_k127_2191677_1 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 306.0
TLS2_k127_2191677_2 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000002589 231.0
TLS2_k127_2191677_3 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000005784 215.0
TLS2_k127_2191677_4 PFAM Hemerythrin HHE cation binding domain protein - - - 0.0000000000000000000003082 108.0
TLS2_k127_2208636_0 cellulose binding - - - 0.0 1051.0
TLS2_k127_2208636_1 ATP-dependent helicase HrpB K03579 - 3.6.4.13 5.138e-286 904.0
TLS2_k127_2208636_10 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 533.0
TLS2_k127_2208636_11 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 482.0
TLS2_k127_2208636_12 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 427.0
TLS2_k127_2208636_13 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 420.0
TLS2_k127_2208636_14 COG3420 Nitrous oxidase accessory protein K07218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000769 404.0
TLS2_k127_2208636_15 NhaP-type Na H and K H - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 374.0
TLS2_k127_2208636_16 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 375.0
TLS2_k127_2208636_17 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 349.0
TLS2_k127_2208636_18 prohibitin homologues K07192 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 353.0
TLS2_k127_2208636_19 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004635 322.0
TLS2_k127_2208636_2 nitrous-oxide reductase activity K00376,K02275 GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234 1.7.2.4,1.9.3.1 1.6e-283 884.0
TLS2_k127_2208636_20 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001595 258.0
TLS2_k127_2208636_21 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001156 252.0
TLS2_k127_2208636_22 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001767 254.0
TLS2_k127_2208636_23 choline dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007437 266.0
TLS2_k127_2208636_24 nitrous oxide K19341 - - 0.00000000000000000000000000000000000000000000000000000000000000008894 234.0
TLS2_k127_2208636_25 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000158 228.0
TLS2_k127_2208636_26 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000001357 220.0
TLS2_k127_2208636_27 lipoprotein involved in nitrous oxide reduction K19342 - - 0.0000000000000000000000000000000000000000000000000000002207 209.0
TLS2_k127_2208636_28 Superoxide dismutase K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000001516 181.0
TLS2_k127_2208636_29 Iron-regulated membrane protein K09939 - - 0.000000000000000000000000000000000000000000000005241 179.0
TLS2_k127_2208636_3 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 1.889e-268 858.0
TLS2_k127_2208636_30 Cupin domain - - - 0.0000000000000000000000000000000000000000000000122 173.0
TLS2_k127_2208636_31 - - - - 0.000000000000000000000000000000000000000002219 167.0
TLS2_k127_2208636_32 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000001314 147.0
TLS2_k127_2208636_33 OsmC-like protein - - - 0.00000000000000000000000000000000004953 140.0
TLS2_k127_2208636_34 Glutathione peroxidase - - - 0.000000000000000000000000000000001048 142.0
TLS2_k127_2208636_35 Thioredoxin-like - - - 0.000000000000000000000000000000001815 139.0
TLS2_k127_2208636_36 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000000009819 126.0
TLS2_k127_2208636_37 Transcriptional regulator - - - 0.00000000000000000000000000001415 123.0
TLS2_k127_2208636_38 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000002018 123.0
TLS2_k127_2208636_39 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000002522 115.0
TLS2_k127_2208636_4 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 6.685e-258 810.0
TLS2_k127_2208636_40 NosL K19342 - - 0.0000000000000000000002068 104.0
TLS2_k127_2208636_41 PFAM blue (type 1) copper domain protein K00368 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 0.0000000000000000000005846 100.0
TLS2_k127_2208636_43 - - - - 0.0000000744 61.0
TLS2_k127_2208636_44 PFAM transport-associated K04065 - - 0.0008796 48.0
TLS2_k127_2208636_5 Domain of unknown function (DUF5118) - - - 5.769e-252 803.0
TLS2_k127_2208636_6 accessory protein K06959 - - 5.108e-209 675.0
TLS2_k127_2208636_7 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 608.0
TLS2_k127_2208636_8 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 577.0
TLS2_k127_2208636_9 ATPase of the ABC class - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 578.0
TLS2_k127_2220963_0 nickel-dependent hydrogenase, large subunit K06281 - 1.12.99.6 3.437e-277 863.0
TLS2_k127_2220963_1 glutaminyl-tRNA K01886 - 6.1.1.18 3.574e-270 852.0
TLS2_k127_2220963_10 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008364 323.0
TLS2_k127_2220963_11 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001288 266.0
TLS2_k127_2220963_12 CDP-alcohol phosphatidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001049 231.0
TLS2_k127_2220963_13 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000000001772 214.0
TLS2_k127_2220963_14 PFAM Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.00000000000000000000000000000000000000002706 173.0
TLS2_k127_2220963_15 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.000000000000000000000000000000000000001682 156.0
TLS2_k127_2220963_16 hyperosmotic response - - - 0.000000000000000000000002271 111.0
TLS2_k127_2220963_17 Transposase, Mutator family K07493 - - 0.000000000000001022 84.0
TLS2_k127_2220963_18 Transposase mutator type - - - 0.00000000000468 70.0
TLS2_k127_2220963_19 - K01822 - 5.3.3.1 0.000001122 57.0
TLS2_k127_2220963_2 Ion transport 2 domain protein - - - 8.37e-230 724.0
TLS2_k127_2220963_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 612.0
TLS2_k127_2220963_4 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282,K18008 - 1.12.2.1,1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 475.0
TLS2_k127_2220963_5 Asparaginase K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 396.0
TLS2_k127_2220963_6 PFAM Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 389.0
TLS2_k127_2220963_7 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 331.0
TLS2_k127_2220963_8 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 334.0
TLS2_k127_2220963_9 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 314.0
TLS2_k127_2223608_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.422e-253 807.0
TLS2_k127_2223608_1 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 1.781e-250 797.0
TLS2_k127_2223608_10 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 375.0
TLS2_k127_2223608_11 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 356.0
TLS2_k127_2223608_12 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 344.0
TLS2_k127_2223608_13 Belongs to the ABC transporter superfamily K02010,K02052,K11084 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 311.0
TLS2_k127_2223608_14 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 315.0
TLS2_k127_2223608_15 Peptidase M15 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001531 276.0
TLS2_k127_2223608_16 LD-carboxypeptidase K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000000000003844 242.0
TLS2_k127_2223608_17 NmrA-like family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000001727 221.0
TLS2_k127_2223608_18 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000001273 209.0
TLS2_k127_2223608_19 ATP cob(I)alamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000007586 199.0
TLS2_k127_2223608_2 3-isopropylmalate dehydratase activity K01681,K01703,K01704,K17749 - 4.2.1.3,4.2.1.33,4.2.1.35 1.399e-222 712.0
TLS2_k127_2223608_20 Transcription elongation factor, N-terminal K03624 - - 0.00000000000000000000000000000000000000000003056 166.0
TLS2_k127_2223608_21 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.000000000000000000000000000000000000000006134 170.0
TLS2_k127_2223608_22 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000005119 146.0
TLS2_k127_2223608_23 NmrA-like family K00091 - 1.1.1.219 0.0000000000000000000000000000000000001228 154.0
TLS2_k127_2223608_24 PFAM phenylacetic acid catabolic family protein K02611 - 1.14.13.149 0.0000000000000000000000000000000000121 146.0
TLS2_k127_2223608_25 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000009902 132.0
TLS2_k127_2223608_26 Transglycosylase SLT domain - - - 0.00000000000000000000000000005507 125.0
TLS2_k127_2223608_27 Pfam:DUF59 K02612 - - 0.0000000000000000000000000002261 125.0
TLS2_k127_2223608_28 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000002562 121.0
TLS2_k127_2223608_29 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000007672 120.0
TLS2_k127_2223608_3 Beta-eliminating lyase K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 528.0
TLS2_k127_2223608_30 PFAM FxsA cytoplasmic membrane protein K07113 - - 0.00000000000000000000000008977 111.0
TLS2_k127_2223608_31 metal-sulfur cluster biosynthetic - - - 0.0000000000000000000000001516 108.0
TLS2_k127_2223608_33 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000005177 102.0
TLS2_k127_2223608_34 chaperone-mediated protein folding - - - 0.000000000000000004605 89.0
TLS2_k127_2223608_35 CAAX protease self-immunity - - - 0.00000000000002923 84.0
TLS2_k127_2223608_36 Bacterial Ig-like domain 2 - - - 0.0000000000003982 84.0
TLS2_k127_2223608_37 Histidine kinase - - - 0.000000000003227 74.0
TLS2_k127_2223608_38 - - - - 0.000000000004423 69.0
TLS2_k127_2223608_4 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 522.0
TLS2_k127_2223608_40 metal-sulfur cluster biosynthetic enzyme - - - 0.00000001472 59.0
TLS2_k127_2223608_43 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000005936 57.0
TLS2_k127_2223608_44 ribosome binding - - - 0.0009263 49.0
TLS2_k127_2223608_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 525.0
TLS2_k127_2223608_6 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 487.0
TLS2_k127_2223608_7 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 489.0
TLS2_k127_2223608_8 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 436.0
TLS2_k127_2223608_9 phenylacetic acid catabolic K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 399.0
TLS2_k127_2254890_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 9.793e-212 669.0
TLS2_k127_2254890_1 COG1228 Imidazolonepropionase and related K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008366 614.0
TLS2_k127_2254890_2 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000098 556.0
TLS2_k127_2254890_3 cytochrome c nitrite reductase K15876 - - 0.0000000000000000000000000000000000000000000000000000000001673 207.0
TLS2_k127_2254890_4 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000000001304 148.0
TLS2_k127_2254890_5 - - - - 0.000005551 58.0
TLS2_k127_2304960_0 Sortilin, neurotensin receptor 3, - - - 9.313e-313 985.0
TLS2_k127_2304960_1 amine dehydrogenase activity K17285 - - 5.786e-238 742.0
TLS2_k127_2304960_10 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000893 417.0
TLS2_k127_2304960_11 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008434 388.0
TLS2_k127_2304960_12 Bacterial protein of unknown function (DUF839) K07093 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005543 374.0
TLS2_k127_2304960_13 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009845 351.0
TLS2_k127_2304960_14 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 365.0
TLS2_k127_2304960_15 esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 332.0
TLS2_k127_2304960_16 TAP-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 317.0
TLS2_k127_2304960_17 Putative esterase K07017 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 295.0
TLS2_k127_2304960_18 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 312.0
TLS2_k127_2304960_19 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004211 304.0
TLS2_k127_2304960_2 glutamate-cysteine ligase activity K00836 - 2.6.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 548.0
TLS2_k127_2304960_20 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001398 282.0
TLS2_k127_2304960_21 NADP oxidoreductase coenzyme F420-dependent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001954 265.0
TLS2_k127_2304960_22 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000005046 271.0
TLS2_k127_2304960_23 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000000000000000000000000000000000007153 243.0
TLS2_k127_2304960_24 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000002974 230.0
TLS2_k127_2304960_25 Glutamate-cysteine ligase family 2(GCS2) - - - 0.00000000000000000000000000000000000000000000000000000000000006642 243.0
TLS2_k127_2304960_26 - - - - 0.000000000000000000000000000000000000000000000000000000000001049 218.0
TLS2_k127_2304960_27 - - - - 0.00000000000000000000000000000000000000000000000000000000001001 218.0
TLS2_k127_2304960_29 - - - - 0.0000000000000000000000000000000000000000000000000000002545 205.0
TLS2_k127_2304960_3 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000827 548.0
TLS2_k127_2304960_30 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000004836 197.0
TLS2_k127_2304960_31 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000001393 192.0
TLS2_k127_2304960_32 - - - - 0.00000000000000000000000000000000000000000000000002349 189.0
TLS2_k127_2304960_33 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000000005967 179.0
TLS2_k127_2304960_34 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000005453 173.0
TLS2_k127_2304960_35 DNA-templated transcription, initiation K02405 - - 0.0000000000000000000000000000000000000000000059 172.0
TLS2_k127_2304960_36 Tetratricopeptide repeat K08309 - - 0.00000000000000000000000000000000000000000119 178.0
TLS2_k127_2304960_37 N-Acetylmuramoyl-L-alanine amidase K01448 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783 3.5.1.28 0.00000000000000000000000000000000000000001512 163.0
TLS2_k127_2304960_38 Peptidase M50 - - - 0.0000000000000000000000000000000000005029 159.0
TLS2_k127_2304960_39 Domain of unknown function (DUF4437) - - - 0.000000000000000000000000000000002539 134.0
TLS2_k127_2304960_4 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 526.0
TLS2_k127_2304960_40 - - - - 0.00000000000000000000000000000002196 134.0
TLS2_k127_2304960_41 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000003709 134.0
TLS2_k127_2304960_42 - - - - 0.0000000000000000000000000000000717 133.0
TLS2_k127_2304960_43 - - - - 0.0000000000000000000000000000005507 134.0
TLS2_k127_2304960_44 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000003505 114.0
TLS2_k127_2304960_45 sequence-specific DNA binding K07726 - - 0.00000000000000000000007935 99.0
TLS2_k127_2304960_46 transcriptional regulator PadR family - - - 0.0000000000000000000002018 102.0
TLS2_k127_2304960_47 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000005264 89.0
TLS2_k127_2304960_48 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000001085 88.0
TLS2_k127_2304960_49 repeat protein - - - 0.00000000000001395 86.0
TLS2_k127_2304960_5 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 529.0
TLS2_k127_2304960_50 RelE toxin of RelE / RelB toxin-antitoxin system - - - 0.00000000001125 66.0
TLS2_k127_2304960_51 Domain of unknown function (DUF4377) - - - 0.00000000002045 76.0
TLS2_k127_2304960_55 Transposase mutator type - - - 0.00000006117 57.0
TLS2_k127_2304960_57 SdpI/YhfL protein family - - - 0.000307 51.0
TLS2_k127_2304960_6 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005501 506.0
TLS2_k127_2304960_7 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 520.0
TLS2_k127_2304960_8 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 475.0
TLS2_k127_2304960_9 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 428.0
TLS2_k127_2380226_0 Sortilin, neurotensin receptor 3, - - - 4.4e-323 1019.0
TLS2_k127_2380226_1 Insulinase (Peptidase family M16) K07263 - - 1.146e-260 835.0
TLS2_k127_2380226_10 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000181 268.0
TLS2_k127_2380226_11 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005734 274.0
TLS2_k127_2380226_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003759 243.0
TLS2_k127_2380226_13 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000759 253.0
TLS2_k127_2380226_14 DinB family - - - 0.00000000000000000000000000000000000000000000000000000000003458 214.0
TLS2_k127_2380226_15 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000000000000000001084 205.0
TLS2_k127_2380226_16 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000001113 210.0
TLS2_k127_2380226_17 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000001504 193.0
TLS2_k127_2380226_18 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000001933 188.0
TLS2_k127_2380226_19 Cupin domain - - - 0.0000000000000000000000000000000000000000000005205 175.0
TLS2_k127_2380226_2 PFAM amidohydrolase - - - 1.839e-201 646.0
TLS2_k127_2380226_20 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000001967 162.0
TLS2_k127_2380226_21 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000005589 149.0
TLS2_k127_2380226_22 Amidohydrolase - - - 0.00000000000000000000000000000000000005404 162.0
TLS2_k127_2380226_23 ubiquinone biosynthetic process - - - 0.0000000000000000000000000000000000275 141.0
TLS2_k127_2380226_24 Thioredoxin - - - 0.000000000000000000000000000000005495 137.0
TLS2_k127_2380226_25 Cell wall-active antibiotics response 4TMS YvqF - - - 0.00000000000000000000000000002657 124.0
TLS2_k127_2380226_26 glyoxalase III activity - - - 0.00000000000000000000000000002961 126.0
TLS2_k127_2380226_28 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000001877 123.0
TLS2_k127_2380226_3 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006246 587.0
TLS2_k127_2380226_30 zinc-ribbon family - - - 0.00000000000000000000000001207 119.0
TLS2_k127_2380226_31 Sulfotransferase family - - - 0.000000000000000000000005901 113.0
TLS2_k127_2380226_32 Immunoglobulin-like domain of bacterial spore germination - - - 0.00000000000000000003745 98.0
TLS2_k127_2380226_33 PFAM Abortive infection protein K07052 - - 0.000000000000000000476 100.0
TLS2_k127_2380226_34 - - - - 0.000000000000000008586 86.0
TLS2_k127_2380226_35 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0000000000000003635 87.0
TLS2_k127_2380226_36 Methyltransferase domain - - - 0.0000000000008283 71.0
TLS2_k127_2380226_37 - - - - 0.00000000003851 73.0
TLS2_k127_2380226_38 - - - - 0.0000002007 58.0
TLS2_k127_2380226_39 Carboxypeptidase regulatory-like domain K02014 - - 0.0000002365 61.0
TLS2_k127_2380226_4 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 447.0
TLS2_k127_2380226_40 CAAX protease self-immunity K07052 - - 0.0000004783 60.0
TLS2_k127_2380226_41 - - - - 0.00005762 51.0
TLS2_k127_2380226_42 23S rRNA-intervening sequence protein - - - 0.0004815 49.0
TLS2_k127_2380226_5 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 437.0
TLS2_k127_2380226_6 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 354.0
TLS2_k127_2380226_7 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 362.0
TLS2_k127_2380226_8 zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006866 341.0
TLS2_k127_2380226_9 phosphoprotein phosphatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000055 288.0
TLS2_k127_239035_0 Tricorn protease C1 domain - - - 0.0 1074.0
TLS2_k127_239035_1 Amidohydrolase family - - - 1.117e-321 1013.0
TLS2_k127_239035_10 PFAM Glycosyl transferase family 4 K13007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008848 421.0
TLS2_k127_239035_11 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 422.0
TLS2_k127_239035_12 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 416.0
TLS2_k127_239035_13 Domain of unknown function DUF87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 397.0
TLS2_k127_239035_14 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008522 403.0
TLS2_k127_239035_15 phosphoprotein phosphatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 376.0
TLS2_k127_239035_16 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 382.0
TLS2_k127_239035_17 PFAM FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 359.0
TLS2_k127_239035_18 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007286 333.0
TLS2_k127_239035_19 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 318.0
TLS2_k127_239035_2 PFAM Amino acid - - - 8.666e-279 918.0
TLS2_k127_239035_20 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 304.0
TLS2_k127_239035_21 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000603 274.0
TLS2_k127_239035_22 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001398 274.0
TLS2_k127_239035_23 heme binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000006117 245.0
TLS2_k127_239035_24 Membrane protein involved in the export of O-antigen and teichoic - - - 0.00000000000000000000000000000000000000000000000000000000000000000009287 251.0
TLS2_k127_239035_25 Involved in the tonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000009434 233.0
TLS2_k127_239035_26 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000000000000000000000001054 218.0
TLS2_k127_239035_27 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000000001135 207.0
TLS2_k127_239035_28 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000005056 214.0
TLS2_k127_239035_29 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000004038 222.0
TLS2_k127_239035_3 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 5.63e-270 840.0
TLS2_k127_239035_30 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000001316 169.0
TLS2_k127_239035_31 peptidase activity - - - 0.0000000000000000000000000000000000000000074 176.0
TLS2_k127_239035_32 Modulates the polysaccharide chain length of enterobacterial common antigen (ECA) - - - 0.00000000000000000000000000000000000000003054 166.0
TLS2_k127_239035_33 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000003563 165.0
TLS2_k127_239035_34 ECF sigma factor - - - 0.000000000000000000000000000000000000007806 152.0
TLS2_k127_239035_35 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000003429 146.0
TLS2_k127_239035_36 Protein of unknown function (DUF1203) - - - 0.000000000000000000000000000000002227 136.0
TLS2_k127_239035_37 - - - - 0.000000000000000000000000002994 120.0
TLS2_k127_239035_38 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000006561 111.0
TLS2_k127_239035_39 COG0433 Predicted ATPase - - - 0.0000000000000000000000001038 108.0
TLS2_k127_239035_4 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 8.05e-246 788.0
TLS2_k127_239035_40 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000001327 117.0
TLS2_k127_239035_41 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000002869 108.0
TLS2_k127_239035_42 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000009092 108.0
TLS2_k127_239035_43 - - - - 0.000000000000000000008527 104.0
TLS2_k127_239035_44 Belongs to the UPF0312 family - - - 0.000000000000000001888 94.0
TLS2_k127_239035_45 DinB family - - - 0.00000000000000001425 86.0
TLS2_k127_239035_46 lactoylglutathione lyase activity - - - 0.0000000001383 74.0
TLS2_k127_239035_48 Ankyrin repeat - - - 0.000000001307 70.0
TLS2_k127_239035_49 Mechanosensitive ion channel - - - 0.000000001634 68.0
TLS2_k127_239035_5 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261,K00262 - 1.4.1.3,1.4.1.4 4.049e-237 745.0
TLS2_k127_239035_50 Zinc ion binding K12035 GO:0000003,GO:0000082,GO:0000278,GO:0000932,GO:0001708,GO:0001838,GO:0001841,GO:0001843,GO:0002009,GO:0002164,GO:0002165,GO:0002168,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005912,GO:0005924,GO:0005927,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006417,GO:0006464,GO:0006725,GO:0006807,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007276,GO:0007399,GO:0007517,GO:0007548,GO:0008150,GO:0008152,GO:0008283,GO:0008543,GO:0008544,GO:0009056,GO:0009057,GO:0009653,GO:0009719,GO:0009790,GO:0009791,GO:0009792,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009913,GO:0009957,GO:0009987,GO:0010033,GO:0010171,GO:0010172,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010586,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0010720,GO:0014020,GO:0014070,GO:0016070,GO:0016071,GO:0016203,GO:0016331,GO:0016441,GO:0016458,GO:0016567,GO:0016740,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0019538,GO:0019787,GO:0019953,GO:0021915,GO:0022402,GO:0022407,GO:0022414,GO:0023052,GO:0030054,GO:0030055,GO:0030154,GO:0030155,GO:0030371,GO:0030674,GO:0030855,GO:0030856,GO:0031047,GO:0031050,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031329,GO:0031331,GO:0032268,GO:0032269,GO:0032446,GO:0032501,GO:0032502,GO:0032504,GO:0032991,GO:0033628,GO:0033632,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0035148,GO:0035194,GO:0035195,GO:0035196,GO:0035198,GO:0035239,GO:0035278,GO:0035295,GO:0035770,GO:0036211,GO:0036464,GO:0040029,GO:0040033,GO:0040034,GO:0042127,GO:0042221,GO:0043009,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043331,GO:0043412,GO:0043487,GO:0043488,GO:0043900,GO:0043902,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044344,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0044706,GO:0044770,GO:0044772,GO:0044843,GO:0045138,GO:0045165,GO:0045182,GO:0045595,GO:0045597,GO:0045604,GO:0045682,GO:0045935,GO:0045974,GO:0046483,GO:0046661,GO:0046700,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048598,GO:0048609,GO:0048646,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0050779,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051704,GO:0051716,GO:0051865,GO:0060090,GO:0060147,GO:0060148,GO:0060255,GO:0060281,GO:0060282,GO:0060284,GO:0060378,GO:0060429,GO:0060538,GO:0060562,GO:0060606,GO:0060964,GO:0060966,GO:0060968,GO:0061013,GO:0061014,GO:0061061,GO:0061157,GO:0061158,GO:0061630,GO:0061659,GO:0061980,GO:0065007,GO:0065008,GO:0070161,GO:0070647,GO:0070848,GO:0070887,GO:0070918,GO:0071310,GO:0071359,GO:0071363,GO:0071407,GO:0071495,GO:0071704,GO:0071774,GO:0072089,GO:0072175,GO:0080090,GO:0090304,GO:0090598,GO:0090727,GO:0097159,GO:0140096,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901575,GO:1901698,GO:1901699,GO:1903047,GO:1903311,GO:1903313,GO:1905879,GO:1905881,GO:1990124,GO:1990904,GO:2000026,GO:2000112,GO:2000113,GO:2000177,GO:2000241,GO:2000243,GO:2000637 2.3.2.27 0.0000001577 63.0
TLS2_k127_239035_51 AsmA-like C-terminal region K07289 - - 0.0000003199 64.0
TLS2_k127_239035_52 self proteolysis K21449 - - 0.000001242 61.0
TLS2_k127_239035_53 DinB family - - - 0.000002095 50.0
TLS2_k127_239035_55 domain, Protein K01387,K14645 - 3.4.24.3 0.00004166 57.0
TLS2_k127_239035_56 DNA-templated transcription, initiation K03088 - - 0.0008318 51.0
TLS2_k127_239035_6 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 587.0
TLS2_k127_239035_7 cysteine synthase A K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 577.0
TLS2_k127_239035_8 Polysaccharide biosynthesis/export protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005201 540.0
TLS2_k127_239035_9 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 526.0
TLS2_k127_2467447_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.294e-261 834.0
TLS2_k127_2467447_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 333.0
TLS2_k127_2467447_2 Peptidase_C39 like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000009365 246.0
TLS2_k127_2467447_3 - - - - 0.0000000000000000000218 96.0
TLS2_k127_2469005_0 Holliday junction DNA helicase ruvB N-terminus K13525 - - 0.0 1079.0
TLS2_k127_2469005_1 C-terminal, D2-small domain, of ClpB protein K11907 - - 1.236e-312 983.0
TLS2_k127_2469005_10 RecQ zinc-binding K03654 - 3.6.4.12 5.345e-217 684.0
TLS2_k127_2469005_100 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003661 271.0
TLS2_k127_2469005_101 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06132 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002657 275.0
TLS2_k127_2469005_102 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004693 278.0
TLS2_k127_2469005_103 Protein kinase domain K08884 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000004221 279.0
TLS2_k127_2469005_104 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000004811 264.0
TLS2_k127_2469005_105 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005087 263.0
TLS2_k127_2469005_106 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007856 261.0
TLS2_k127_2469005_107 Uncharacterized protein conserved in bacteria (DUF2169) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000272 271.0
TLS2_k127_2469005_108 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003153 259.0
TLS2_k127_2469005_109 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000001022 260.0
TLS2_k127_2469005_11 domain, Protein - - - 4.028e-215 690.0
TLS2_k127_2469005_110 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000027 258.0
TLS2_k127_2469005_111 nitrite reductase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000878 254.0
TLS2_k127_2469005_112 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000149 262.0
TLS2_k127_2469005_113 Peptidase family M23 K21472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000273 255.0
TLS2_k127_2469005_114 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000345 251.0
TLS2_k127_2469005_115 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000005615 254.0
TLS2_k127_2469005_116 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000001465 247.0
TLS2_k127_2469005_117 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000001683 248.0
TLS2_k127_2469005_118 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000001067 246.0
TLS2_k127_2469005_119 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000167 233.0
TLS2_k127_2469005_12 Type VI secretion system, TssF K11896 - - 1.084e-211 675.0
TLS2_k127_2469005_120 Glycine zipper - - - 0.000000000000000000000000000000000000000000000000000000000000000005745 231.0
TLS2_k127_2469005_121 Zn_pept - - - 0.000000000000000000000000000000000000000000000000000000000000000009384 251.0
TLS2_k127_2469005_122 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000006389 235.0
TLS2_k127_2469005_123 PDZ domain (Also known as DHR or GLGF) - - - 0.00000000000000000000000000000000000000000000000000000000000000007856 236.0
TLS2_k127_2469005_124 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000009045 226.0
TLS2_k127_2469005_125 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000000000000321 226.0
TLS2_k127_2469005_126 Type VI secretion system, VipA, VC_A0107 or Hcp2 K11901 - - 0.000000000000000000000000000000000000000000000000000000000000001836 223.0
TLS2_k127_2469005_127 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000004361 230.0
TLS2_k127_2469005_128 - - - - 0.0000000000000000000000000000000000000000000000000000000000000765 239.0
TLS2_k127_2469005_129 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000002706 217.0
TLS2_k127_2469005_13 MacB-like periplasmic core domain - - - 6.662e-201 653.0
TLS2_k127_2469005_130 Belongs to the phosphatidylserine decarboxylase family K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000006733 218.0
TLS2_k127_2469005_131 Flavin-binding monooxygenase-like K07222 - - 0.0000000000000000000000000000000000000000000000000000000001548 220.0
TLS2_k127_2469005_132 cytochrome c oxidase (Subunit II) - - - 0.0000000000000000000000000000000000000000000000000000000001723 211.0
TLS2_k127_2469005_133 Type VI secretion system effector, Hcp K11903 - - 0.000000000000000000000000000000000000000000000000000000008069 201.0
TLS2_k127_2469005_134 ATPase activity K02065 - - 0.00000000000000000000000000000000000000000000000000000009048 205.0
TLS2_k127_2469005_135 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000001212 193.0
TLS2_k127_2469005_136 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - 0.000000000000000000000000000000000000000000000000001718 190.0
TLS2_k127_2469005_137 Type VI secretion system protein DotU K11892 - - 0.000000000000000000000000000000000000000000000000003345 190.0
TLS2_k127_2469005_138 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.000000000000000000000000000000000000000000000000004245 196.0
TLS2_k127_2469005_139 Protein of unknown function (DUF664) - - - 0.000000000000000000000000000000000000000000000000006821 187.0
TLS2_k127_2469005_14 permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 4.218e-198 631.0
TLS2_k127_2469005_140 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000008317 199.0
TLS2_k127_2469005_141 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000009655 198.0
TLS2_k127_2469005_142 Cytochrome C and Quinol oxidase polypeptide I - - - 0.0000000000000000000000000000000000000000000000002421 180.0
TLS2_k127_2469005_143 Low temperature requirement - - - 0.000000000000000000000000000000000000000000000001795 188.0
TLS2_k127_2469005_144 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000009556 183.0
TLS2_k127_2469005_145 - - - - 0.000000000000000000000000000000000000000000000009682 184.0
TLS2_k127_2469005_146 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000000008721 173.0
TLS2_k127_2469005_147 - - - - 0.0000000000000000000000000000000000000000000001008 181.0
TLS2_k127_2469005_148 DinB family - - - 0.0000000000000000000000000000000000000000000008399 175.0
TLS2_k127_2469005_149 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000001195 173.0
TLS2_k127_2469005_15 heme-copper terminal oxidase activity K02274 - 1.9.3.1 4.453e-196 629.0
TLS2_k127_2469005_150 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000003132 166.0
TLS2_k127_2469005_151 Rhodanese-like domain - - - 0.00000000000000000000000000000000000000000004971 165.0
TLS2_k127_2469005_152 COG0073 EMAP domain K06878 - - 0.00000000000000000000000000000000000000000009234 163.0
TLS2_k127_2469005_153 YjbR - - - 0.0000000000000000000000000000000000000000005233 163.0
TLS2_k127_2469005_154 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000004598 159.0
TLS2_k127_2469005_155 surface antigen variable number repeat protein K07001 - - 0.0000000000000000000000000000000000000002732 171.0
TLS2_k127_2469005_156 Permease MlaE K02066 - - 0.000000000000000000000000000000000000009934 155.0
TLS2_k127_2469005_157 curli production assembly transport component CsgG K04087 - - 0.0000000000000000000000000000000000000105 162.0
TLS2_k127_2469005_159 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000000000000197 146.0
TLS2_k127_2469005_16 ImcF-related N-terminal domain K11891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 644.0
TLS2_k127_2469005_160 Peptidase M14, carboxypeptidase A - - - 0.00000000000000000000000000000000000003817 162.0
TLS2_k127_2469005_161 - - - - 0.00000000000000000000000000000000000004471 158.0
TLS2_k127_2469005_162 SWI complex, BAF60b domains - - - 0.00000000000000000000000000000000000008499 148.0
TLS2_k127_2469005_163 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000002779 147.0
TLS2_k127_2469005_164 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000003391 148.0
TLS2_k127_2469005_165 - - - - 0.000000000000000000000000000000001248 139.0
TLS2_k127_2469005_166 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.000000000000000000000000000000002041 147.0
TLS2_k127_2469005_167 - - - - 0.00000000000000000000000000000000873 138.0
TLS2_k127_2469005_168 Gene 25-like lysozyme K11897 - - 0.00000000000000000000000000000002978 132.0
TLS2_k127_2469005_169 OmpA family K03640 - - 0.000000000000000000000000000008413 132.0
TLS2_k127_2469005_17 N-acetyldiaminopimelate deacetylase activity K12941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 584.0
TLS2_k127_2469005_170 PFAM regulatory protein, ArsR K03892 - - 0.00000000000000000000000000001201 124.0
TLS2_k127_2469005_171 protein kinase activity - - - 0.00000000000000000000000000001876 130.0
TLS2_k127_2469005_172 cheY-homologous receiver domain - - - 0.00000000000000000000000000009539 119.0
TLS2_k127_2469005_173 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.0000000000000000000000000001964 119.0
TLS2_k127_2469005_174 - - - - 0.000000000000000000000000001081 123.0
TLS2_k127_2469005_175 transferase activity, transferring glycosyl groups K01179,K12567,K20276,K21000 - 2.7.11.1,3.2.1.4 0.000000000000000000000000001096 131.0
TLS2_k127_2469005_176 Wd-40 repeat - - - 0.00000000000000000000000001101 116.0
TLS2_k127_2469005_177 PhoU domain - - - 0.00000000000000000000000001102 119.0
TLS2_k127_2469005_178 Peptidase, M23 - - - 0.00000000000000000000000004454 119.0
TLS2_k127_2469005_179 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000008992 114.0
TLS2_k127_2469005_18 Rhodanese Homology Domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 591.0
TLS2_k127_2469005_180 Tellurite resistance protein TerB - - - 0.0000000000000000000000001503 112.0
TLS2_k127_2469005_181 Protein of unknown function (DUF3667) - - - 0.0000000000000000000000001509 117.0
TLS2_k127_2469005_182 - - - - 0.000000000000000000000001751 109.0
TLS2_k127_2469005_183 - - - - 0.000000000000000000000003969 110.0
TLS2_k127_2469005_184 Belongs to the P-Pant transferase superfamily K06133 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.00000000000000000000001056 114.0
TLS2_k127_2469005_185 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.000000000000000000008488 98.0
TLS2_k127_2469005_187 Tetratricopeptide repeat - - - 0.0000000000000000003339 103.0
TLS2_k127_2469005_188 acyl carrier protein - - - 0.0000000000000000003346 90.0
TLS2_k127_2469005_189 BON domain - - - 0.0000000000000000003683 97.0
TLS2_k127_2469005_19 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009213 574.0
TLS2_k127_2469005_190 domain, Protein - - - 0.000000000000000001718 101.0
TLS2_k127_2469005_193 DinB superfamily - - - 0.0000000000000001536 87.0
TLS2_k127_2469005_194 Polymer-forming cytoskeletal - - - 0.0000000000000003255 84.0
TLS2_k127_2469005_195 - - - - 0.0000000000000005618 82.0
TLS2_k127_2469005_196 Protein of unknown function (DUF4235) - - - 0.000000000000002389 79.0
TLS2_k127_2469005_198 Carboxypeptidase regulatory-like domain K02014 - - 0.00000000000002849 84.0
TLS2_k127_2469005_199 - - - - 0.00000000000003498 79.0
TLS2_k127_2469005_2 Malic enzyme, NAD binding domain K00027,K00029,K00625,K04020,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 1.21e-279 880.0
TLS2_k127_2469005_20 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 584.0
TLS2_k127_2469005_200 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.00000000000003793 85.0
TLS2_k127_2469005_201 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.00000000000004866 77.0
TLS2_k127_2469005_202 Mammalian cell entry related domain protein K02067 - - 0.0000000000001111 82.0
TLS2_k127_2469005_203 Electron transport protein SCO1 SenC K07152 - - 0.000000000009866 76.0
TLS2_k127_2469005_205 ATPases associated with a variety of cellular activities K01990 - - 0.00000000001662 76.0
TLS2_k127_2469005_206 protein involved in formation of curli polymers - - - 0.00000000003268 77.0
TLS2_k127_2469005_207 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000351 68.0
TLS2_k127_2469005_209 Periplasmic or secreted lipoprotein - - - 0.000000009172 64.0
TLS2_k127_2469005_21 negative regulation of protein lipidation K19294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 589.0
TLS2_k127_2469005_210 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.00000001209 65.0
TLS2_k127_2469005_211 NlpC/P60 family - - - 0.00000001815 66.0
TLS2_k127_2469005_212 amine dehydrogenase activity - - - 0.00000002116 67.0
TLS2_k127_2469005_213 - - - - 0.00000002596 62.0
TLS2_k127_2469005_214 Forkhead associated domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.00000004093 66.0
TLS2_k127_2469005_215 Outer membrane protein beta-barrel domain - - - 0.00000008543 63.0
TLS2_k127_2469005_216 anti-sigma factor - GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.0000004604 56.0
TLS2_k127_2469005_217 - - - - 0.000001248 57.0
TLS2_k127_2469005_218 Universal stress protein - - - 0.000002183 55.0
TLS2_k127_2469005_219 Bacterial protein of unknown function (DUF922) - - - 0.00000269 55.0
TLS2_k127_2469005_22 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 580.0
TLS2_k127_2469005_220 metal cluster binding - - - 0.000006426 54.0
TLS2_k127_2469005_221 Protein of unknown function (DUF456) K09793 - - 0.00001096 55.0
TLS2_k127_2469005_222 Transcriptional regulator padr family - - - 0.00001244 57.0
TLS2_k127_2469005_223 peptidase S1 and S6, chymotrypsin Hap K08372 - - 0.00001562 57.0
TLS2_k127_2469005_224 - - - - 0.00006121 55.0
TLS2_k127_2469005_225 OHCU decarboxylase K16840 - 4.1.1.97 0.000122 50.0
TLS2_k127_2469005_226 - - - - 0.0002187 46.0
TLS2_k127_2469005_227 Helix-turn-helix - - - 0.0002688 48.0
TLS2_k127_2469005_228 COG3653 N-acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.0004158 52.0
TLS2_k127_2469005_229 Outer membrane protein beta-barrel domain - - - 0.000456 50.0
TLS2_k127_2469005_23 PFAM Protein kinase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 585.0
TLS2_k127_2469005_24 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008335 576.0
TLS2_k127_2469005_25 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 555.0
TLS2_k127_2469005_26 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 548.0
TLS2_k127_2469005_27 ATP ADP translocase K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009943 543.0
TLS2_k127_2469005_28 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 576.0
TLS2_k127_2469005_29 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009754 545.0
TLS2_k127_2469005_3 TonB dependent receptor - - - 1.26e-269 863.0
TLS2_k127_2469005_30 Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 524.0
TLS2_k127_2469005_31 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 518.0
TLS2_k127_2469005_32 P-loop ATPase protein family K06958,K07102 GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 510.0
TLS2_k127_2469005_33 ImpA, N-terminal, type VI secretion system K11902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 507.0
TLS2_k127_2469005_34 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 514.0
TLS2_k127_2469005_35 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 495.0
TLS2_k127_2469005_36 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 486.0
TLS2_k127_2469005_37 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 507.0
TLS2_k127_2469005_38 PFAM peptidase M14 carboxypeptidase A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 490.0
TLS2_k127_2469005_39 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 501.0
TLS2_k127_2469005_4 Prolyl oligopeptidase family - - - 6.332e-263 835.0
TLS2_k127_2469005_40 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009181 475.0
TLS2_k127_2469005_41 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004222 470.0
TLS2_k127_2469005_42 Surface antigen K07277,K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 483.0
TLS2_k127_2469005_43 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 476.0
TLS2_k127_2469005_44 Phage late control gene D protein (GPD) K11904 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 466.0
TLS2_k127_2469005_45 Predicted methyltransferase regulatory domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 454.0
TLS2_k127_2469005_46 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 451.0
TLS2_k127_2469005_47 SusD family K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 445.0
TLS2_k127_2469005_48 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 464.0
TLS2_k127_2469005_49 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 445.0
TLS2_k127_2469005_5 Zn_pept - - - 7.472e-249 784.0
TLS2_k127_2469005_50 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005207 447.0
TLS2_k127_2469005_51 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 426.0
TLS2_k127_2469005_52 ABC-type Fe3 transport system permease K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 442.0
TLS2_k127_2469005_53 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000766 424.0
TLS2_k127_2469005_54 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 432.0
TLS2_k127_2469005_55 PFAM Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007684 422.0
TLS2_k127_2469005_56 Pyruvate dehydrogenase K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 415.0
TLS2_k127_2469005_57 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 422.0
TLS2_k127_2469005_58 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 415.0
TLS2_k127_2469005_59 COG0842 ABC-type multidrug transport system, permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 410.0
TLS2_k127_2469005_6 Type VI secretion protein, EvpB/VC_A0108, tail sheath K11900 - - 9.64e-236 737.0
TLS2_k127_2469005_60 helix_turn_helix gluconate operon transcriptional repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 412.0
TLS2_k127_2469005_61 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 407.0
TLS2_k127_2469005_62 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 409.0
TLS2_k127_2469005_63 Dihydroorotate dehydrogenase K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 398.0
TLS2_k127_2469005_64 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 389.0
TLS2_k127_2469005_65 COG1914 Mn2 and Fe2 transporters of the NRAMP family K03322 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 385.0
TLS2_k127_2469005_66 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 382.0
TLS2_k127_2469005_67 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 377.0
TLS2_k127_2469005_68 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009204 389.0
TLS2_k127_2469005_69 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 371.0
TLS2_k127_2469005_7 TamB, inner membrane protein subunit of TAM complex K09800 - - 3.157e-233 782.0
TLS2_k127_2469005_70 PFAM Na Pi-cotransporter K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 385.0
TLS2_k127_2469005_71 Amidohydrolase family K01464,K01466 - 3.5.2.2,3.5.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 369.0
TLS2_k127_2469005_72 Hypothetical methyltransferase K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009288 365.0
TLS2_k127_2469005_73 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 359.0
TLS2_k127_2469005_74 Na+/Pi-cotransporter K03324,K14683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 383.0
TLS2_k127_2469005_75 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006026 356.0
TLS2_k127_2469005_76 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 342.0
TLS2_k127_2469005_77 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007764 328.0
TLS2_k127_2469005_78 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 321.0
TLS2_k127_2469005_79 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 316.0
TLS2_k127_2469005_8 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 4.832e-229 739.0
TLS2_k127_2469005_80 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 323.0
TLS2_k127_2469005_81 Uncharacterized protein conserved in bacteria (DUF2169) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 321.0
TLS2_k127_2469005_82 Extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 314.0
TLS2_k127_2469005_83 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 311.0
TLS2_k127_2469005_84 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 331.0
TLS2_k127_2469005_85 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006933 310.0
TLS2_k127_2469005_86 type VI secretion protein, VC_A0111 family K11895 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 310.0
TLS2_k127_2469005_87 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 303.0
TLS2_k127_2469005_88 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 301.0
TLS2_k127_2469005_89 exonuclease activity K16899 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 321.0
TLS2_k127_2469005_9 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 1.927e-228 716.0
TLS2_k127_2469005_90 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 289.0
TLS2_k127_2469005_91 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 288.0
TLS2_k127_2469005_92 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000284 291.0
TLS2_k127_2469005_93 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 288.0
TLS2_k127_2469005_94 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002353 289.0
TLS2_k127_2469005_95 ImpE protein K11898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004991 278.0
TLS2_k127_2469005_96 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002005 292.0
TLS2_k127_2469005_97 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001333 279.0
TLS2_k127_2469005_98 Putative glycosyl hydrolase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001987 282.0
TLS2_k127_2469005_99 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002979 276.0
TLS2_k127_2527256_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 4.472e-210 669.0
TLS2_k127_2527256_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 450.0
TLS2_k127_2527256_10 FAD dependent oxidoreductase K00285,K03153 - 1.4.3.19,1.4.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000003024 255.0
TLS2_k127_2527256_11 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000004653 250.0
TLS2_k127_2527256_12 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.0000000000000000000000000000000000000000000000000000000000000000002787 241.0
TLS2_k127_2527256_13 CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000008569 232.0
TLS2_k127_2527256_14 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.0000000000000000000000000000000000000000000000000000008897 204.0
TLS2_k127_2527256_15 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000001362 196.0
TLS2_k127_2527256_16 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000003376 172.0
TLS2_k127_2527256_17 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000003371 161.0
TLS2_k127_2527256_18 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000002978 132.0
TLS2_k127_2527256_19 Intracellular proteinase inhibitor - - - 0.0000000000000001366 85.0
TLS2_k127_2527256_2 Na dependent nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 449.0
TLS2_k127_2527256_20 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000007703 81.0
TLS2_k127_2527256_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000411 419.0
TLS2_k127_2527256_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 341.0
TLS2_k127_2527256_5 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002967 265.0
TLS2_k127_2527256_6 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000003815 283.0
TLS2_k127_2527256_7 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004715 269.0
TLS2_k127_2527256_8 PFAM Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001893 251.0
TLS2_k127_2527256_9 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000452 253.0
TLS2_k127_2664711_0 type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 505.0
TLS2_k127_2664711_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004603 504.0
TLS2_k127_2664711_10 PFAM SAF domain K02279 - - 0.0000000000000000000000000000000000000000000000000007956 194.0
TLS2_k127_2664711_11 Type II secretion system (T2SS), protein F K12510 - - 0.0000000000000000000000000000000000000000000003271 183.0
TLS2_k127_2664711_12 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000002865 178.0
TLS2_k127_2664711_13 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000001546 171.0
TLS2_k127_2664711_14 Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing K02282 - - 0.000000000000000000000000000000000002143 155.0
TLS2_k127_2664711_15 Histidine kinase - - - 0.0000000000000000000000000000000001603 151.0
TLS2_k127_2664711_16 PFAM Glycosyl transferase family 2 K12992 - - 0.0000000000000000000000000000000002752 144.0
TLS2_k127_2664711_17 Glycosyltransferase family 87 - - - 0.00000000000000000000000002008 123.0
TLS2_k127_2664711_18 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000004865 108.0
TLS2_k127_2664711_19 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000005068 74.0
TLS2_k127_2664711_2 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 396.0
TLS2_k127_2664711_20 Peptidase A24A, prepilin type IV K02278 - 3.4.23.43 0.0000000007049 66.0
TLS2_k127_2664711_21 TadE-like protein - - - 0.000000008484 63.0
TLS2_k127_2664711_22 Circadian clock protein KaiC K08482 - - 0.0000003408 63.0
TLS2_k127_2664711_23 PFAM Radical SAM - - - 0.0000003572 63.0
TLS2_k127_2664711_24 - - - - 0.000001901 58.0
TLS2_k127_2664711_25 PFAM Flp Fap pilin component K02651 - - 0.0001057 49.0
TLS2_k127_2664711_26 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000471 53.0
TLS2_k127_2664711_3 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 367.0
TLS2_k127_2664711_4 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 344.0
TLS2_k127_2664711_5 Polysaccharide pyruvyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 320.0
TLS2_k127_2664711_6 Belongs to the GSP D family K02280 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002326 267.0
TLS2_k127_2664711_7 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000003474 243.0
TLS2_k127_2664711_8 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001142 249.0
TLS2_k127_2664711_9 Type II secretion system (T2SS), protein F K12511 - - 0.000000000000000000000000000000000000000000000000000000006873 209.0
TLS2_k127_2674010_0 efflux transmembrane transporter activity - - - 2.91e-234 755.0
TLS2_k127_2674010_1 Sulfate permease family K03321 - - 6.686e-223 704.0
TLS2_k127_2674010_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000646 285.0
TLS2_k127_2674010_11 Type 12 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002052 252.0
TLS2_k127_2674010_12 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000004078 228.0
TLS2_k127_2674010_13 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000011 223.0
TLS2_k127_2674010_14 Prephenate dehydratase K04518,K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000007097 201.0
TLS2_k127_2674010_15 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000000000000000001668 196.0
TLS2_k127_2674010_16 Guanylate kinase homologues. K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000003762 185.0
TLS2_k127_2674010_17 Telomere recombination K07566 - 2.7.7.87 0.000000000000000000000000000000000000007978 154.0
TLS2_k127_2674010_18 phosphorelay sensor kinase activity - - - 0.00000000000000000000000000000000000002021 164.0
TLS2_k127_2674010_19 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000002676 138.0
TLS2_k127_2674010_2 D-aminoacylase domain protein K01465,K06015 - 3.5.1.81,3.5.2.3 9.813e-199 635.0
TLS2_k127_2674010_20 Outer membrane protein beta-barrel domain - - - 0.0000000000000000000000000000000005997 141.0
TLS2_k127_2674010_21 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000001951 123.0
TLS2_k127_2674010_22 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000001732 113.0
TLS2_k127_2674010_23 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.00000000000000000006352 97.0
TLS2_k127_2674010_24 TonB-dependent Receptor Plug Domain - - - 0.0000000000000002192 93.0
TLS2_k127_2674010_25 Chorismate mutase K00661,K04092,K04093,K04516,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.3.1.79,4.2.1.51,5.4.99.5 0.000000000000007134 79.0
TLS2_k127_2674010_26 COG0457 FOG TPR repeat - - - 0.00000000000002667 84.0
TLS2_k127_2674010_27 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.00000000003233 65.0
TLS2_k127_2674010_28 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000002525 73.0
TLS2_k127_2674010_29 Domain of unknown function (DUF4142) K08995 - - 0.00000001476 64.0
TLS2_k127_2674010_3 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 531.0
TLS2_k127_2674010_4 Replicative DNA helicase K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 458.0
TLS2_k127_2674010_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 453.0
TLS2_k127_2674010_6 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009771 432.0
TLS2_k127_2674010_7 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 398.0
TLS2_k127_2674010_8 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 378.0
TLS2_k127_2674010_9 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009211 354.0
TLS2_k127_2692662_0 chorismate binding enzyme K01665,K02619,K03342,K13503,K13950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.85,4.1.3.27,4.1.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 541.0
TLS2_k127_2692662_1 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 481.0
TLS2_k127_2692662_10 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000009183 211.0
TLS2_k127_2692662_11 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000003481 206.0
TLS2_k127_2692662_12 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000001281 185.0
TLS2_k127_2692662_13 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000008362 164.0
TLS2_k127_2692662_14 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000003633 164.0
TLS2_k127_2692662_15 DUF218 domain - - - 0.000000000000000000000000000000000000004466 153.0
TLS2_k127_2692662_16 Penicillinase repressor - - - 0.000000000000000000000000000000000000006683 149.0
TLS2_k127_2692662_17 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000007061 144.0
TLS2_k127_2692662_18 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000007803 120.0
TLS2_k127_2692662_19 ErfK ybiS ycfS ynhG family protein K19234 - - 0.0000000000000000000000001125 116.0
TLS2_k127_2692662_2 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 475.0
TLS2_k127_2692662_20 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000001796 102.0
TLS2_k127_2692662_21 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000001569 91.0
TLS2_k127_2692662_22 Flavin containing amine oxidoreductase - - - 0.000000000000000001927 99.0
TLS2_k127_2692662_23 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657,K07658 - - 0.00000000000000004891 85.0
TLS2_k127_2692662_24 - - - - 0.0000000000000005041 88.0
TLS2_k127_2692662_25 Scaffold protein Nfu/NifU N terminal - - - 0.0000000000000005571 81.0
TLS2_k127_2692662_26 - - - - 0.00000008962 62.0
TLS2_k127_2692662_27 Sporulation related domain - - - 0.0000006639 59.0
TLS2_k127_2692662_28 Psort location Periplasmic, score 9.44 - - - 0.000004316 58.0
TLS2_k127_2692662_29 peptidyl-tyrosine sulfation - - - 0.000007137 57.0
TLS2_k127_2692662_3 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 452.0
TLS2_k127_2692662_30 Peptidase M16 - - - 0.00001218 54.0
TLS2_k127_2692662_31 TonB-dependent Receptor Plug Domain - - - 0.00002601 57.0
TLS2_k127_2692662_32 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.00003613 50.0
TLS2_k127_2692662_33 Insulinase (Peptidase family M16) - - - 0.0001212 48.0
TLS2_k127_2692662_34 Belongs to the peptidase S1C family K04691,K04771,K04772 - 3.4.21.107 0.0007022 51.0
TLS2_k127_2692662_35 PFAM von Willebrand factor type A - - - 0.0008765 51.0
TLS2_k127_2692662_4 metalloenzyme domain protein K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006792 415.0
TLS2_k127_2692662_5 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 344.0
TLS2_k127_2692662_6 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 345.0
TLS2_k127_2692662_7 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 332.0
TLS2_k127_2692662_8 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 304.0
TLS2_k127_2692662_9 Aminotransferase class-V K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001434 289.0
TLS2_k127_2753855_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009518 535.0
TLS2_k127_2753855_1 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 336.0
TLS2_k127_2753855_10 Periplasmic component of the Tol biopolymer transport system K03641 - - 0.00000579 59.0
TLS2_k127_2753855_2 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000003022 217.0
TLS2_k127_2753855_3 Peptidase family S41 - - - 0.0000000000000000000000000000000000000000000001148 182.0
TLS2_k127_2753855_4 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000003492 186.0
TLS2_k127_2753855_5 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000093 105.0
TLS2_k127_2753855_6 MacB-like periplasmic core domain - - - 0.00000000000000003526 93.0
TLS2_k127_2753855_7 negative regulation of transcription, DNA-templated - - - 0.00000000000000005285 85.0
TLS2_k127_2753855_8 cell redox homeostasis - - - 0.0000000009774 72.0
TLS2_k127_2753855_9 ATP-binding region, ATPase domain protein domain protein - - - 0.000003529 51.0
TLS2_k127_2817852_0 undecaprenyl-phosphate glucose phosphotransferase activity K00996 - 2.7.8.6 0.000000000000000000627 87.0
TLS2_k127_2817852_1 - - - - 0.0000000001791 74.0
TLS2_k127_284253_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 3.777e-245 779.0
TLS2_k127_284253_1 Chlorophyllase enzyme - - - 7.271e-201 644.0
TLS2_k127_284253_10 NmrA family - - - 0.0000000000000000000000000000000000000000000000000000000000008944 220.0
TLS2_k127_284253_11 L,D-transpeptidase catalytic domain K16291 - - 0.000000000000000000000000000000000000000000000000009145 192.0
TLS2_k127_284253_12 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000005346 166.0
TLS2_k127_284253_13 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000006436 153.0
TLS2_k127_284253_14 - - - - 0.000000000000000000000000000001196 139.0
TLS2_k127_284253_15 Hydrogenase expression formation protein K04653 - - 0.000000000000000000001158 98.0
TLS2_k127_284253_16 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000000000271 98.0
TLS2_k127_284253_17 long-chain fatty acid transport protein - - - 0.000000000000000000005608 104.0
TLS2_k127_284253_2 hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 527.0
TLS2_k127_284253_3 Rieske (2fe-2S) K00499 - 1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 463.0
TLS2_k127_284253_4 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 428.0
TLS2_k127_284253_5 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 354.0
TLS2_k127_284253_6 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001736 272.0
TLS2_k127_284253_7 Belongs to the serpin family K13963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003027 276.0
TLS2_k127_284253_8 Signal transduction histidine kinase, LytS K02478 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000001219 233.0
TLS2_k127_284253_9 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000002372 221.0
TLS2_k127_2862204_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 443.0
TLS2_k127_2862204_1 TIGRFAM sugar transferase, PEP-CTERM system associated K21303 - 2.7.8.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001975 277.0
TLS2_k127_2904788_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 614.0
TLS2_k127_2904788_1 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 588.0
TLS2_k127_2904788_10 - - - - 0.000000000000000003222 91.0
TLS2_k127_2904788_11 succinyl-diaminopimelate desuccinylase activity K01438 - 3.5.1.16 0.0000002819 55.0
TLS2_k127_2904788_12 helix_turn_helix, arabinose operon control protein - - - 0.00002748 51.0
TLS2_k127_2904788_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 447.0
TLS2_k127_2904788_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005418 295.0
TLS2_k127_2904788_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000001169 244.0
TLS2_k127_2904788_5 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000001226 247.0
TLS2_k127_2904788_6 Beta-lactamase - - - 0.0000000000000000000000000000000000000000003082 179.0
TLS2_k127_2904788_7 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000009284 161.0
TLS2_k127_2904788_8 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000001902 120.0
TLS2_k127_2904788_9 - - - - 0.000000000000000002225 95.0
TLS2_k127_2917387_0 PFAM Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 1.928e-212 681.0
TLS2_k127_2917387_1 Glycosyl transferase family 21 K00786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 561.0
TLS2_k127_2917387_10 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 378.0
TLS2_k127_2917387_11 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 364.0
TLS2_k127_2917387_12 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 319.0
TLS2_k127_2917387_13 (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000001791 244.0
TLS2_k127_2917387_14 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000000002496 232.0
TLS2_k127_2917387_15 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000981 228.0
TLS2_k127_2917387_16 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000005661 203.0
TLS2_k127_2917387_17 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000004813 188.0
TLS2_k127_2917387_18 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000001157 173.0
TLS2_k127_2917387_19 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000397 173.0
TLS2_k127_2917387_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 552.0
TLS2_k127_2917387_20 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000000000107 176.0
TLS2_k127_2917387_21 - - - - 0.00000000000000000000000000000000000000000006245 168.0
TLS2_k127_2917387_22 PTS system sorbose subfamily IIB component K19507 - - 0.00000000000000000000000000000000000000001991 159.0
TLS2_k127_2917387_23 PTS system mannose/fructose/sorbose family IID component K02796 - - 0.0000000000000000000000000000000000000008232 167.0
TLS2_k127_2917387_24 RES - - - 0.000000000000000000000000000000000000004432 151.0
TLS2_k127_2917387_25 TIGRFAM Diguanylate cyclase - - - 0.00000000000000000000000000000000000001162 166.0
TLS2_k127_2917387_26 - - - - 0.0000000000000000000000000000000000008618 146.0
TLS2_k127_2917387_27 PFAM Response regulator receiver domain K07668 - - 0.000000000000000000000000000000000003377 151.0
TLS2_k127_2917387_28 Dioxygenase K00449 - 1.13.11.3 0.000000000000000000000000000000000005221 148.0
TLS2_k127_2917387_29 Biotin-requiring enzyme - - - 0.00000000000000000000000000000000002947 145.0
TLS2_k127_2917387_3 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 522.0
TLS2_k127_2917387_30 Transposase zinc-binding domain - - - 0.0000000000000000000000000000000001314 143.0
TLS2_k127_2917387_31 HEAT repeats - - - 0.000000000000000000000000000008848 133.0
TLS2_k127_2917387_32 Protein of unknown function (DUF2384) - - - 0.00000000000000000000000000008332 121.0
TLS2_k127_2917387_33 - - - - 0.0000000000000000000000000004453 126.0
TLS2_k127_2917387_34 cheY-homologous receiver domain - - - 0.0000000000000000000000000007777 120.0
TLS2_k127_2917387_35 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000000000000000009349 110.0
TLS2_k127_2917387_36 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000000001045 110.0
TLS2_k127_2917387_37 Tetratricopeptide repeat - - - 0.00000000000000000000000475 116.0
TLS2_k127_2917387_38 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000005215 106.0
TLS2_k127_2917387_39 PFAM YcfA-like protein - - - 0.00000000000000000000001051 101.0
TLS2_k127_2917387_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 435.0
TLS2_k127_2917387_40 DoxX-like family - - - 0.00000000000000000000128 99.0
TLS2_k127_2917387_41 Putative regulatory protein - - - 0.000000000000000000002044 98.0
TLS2_k127_2917387_42 SnoaL-like domain - - - 0.000000000000000000004181 98.0
TLS2_k127_2917387_43 PTS system sorbose-specific iic component K02795 - - 0.000000000000000000228 97.0
TLS2_k127_2917387_44 protein secretion K21449 - - 0.00000000000000006076 86.0
TLS2_k127_2917387_45 - - - - 0.0000000000000003806 88.0
TLS2_k127_2917387_47 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K05296 - 1.1.1.51 0.00000000000004125 76.0
TLS2_k127_2917387_48 protein kinase activity - - - 0.0000000000005146 82.0
TLS2_k127_2917387_49 - - - - 0.0000000000009196 78.0
TLS2_k127_2917387_5 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 437.0
TLS2_k127_2917387_50 DinB superfamily - - - 0.00000000002525 68.0
TLS2_k127_2917387_51 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000000001763 67.0
TLS2_k127_2917387_52 transferase activity, transferring glycosyl groups K13500 - 2.4.1.175,2.4.1.226 0.0000000002798 74.0
TLS2_k127_2917387_53 Fic/DOC family N-terminal - - - 0.000000001017 74.0
TLS2_k127_2917387_55 GlcNAc-PI de-N-acetylase - - - 0.00000006116 60.0
TLS2_k127_2917387_56 C4-type zinc ribbon domain K07164 - - 0.00000008402 61.0
TLS2_k127_2917387_57 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.0000006387 59.0
TLS2_k127_2917387_58 PTS system fructose IIA component - - - 0.00000508 54.0
TLS2_k127_2917387_59 Histidine kinase - - - 0.00001046 53.0
TLS2_k127_2917387_6 elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 430.0
TLS2_k127_2917387_60 Dioxygenase - - - 0.00001312 54.0
TLS2_k127_2917387_61 - - - - 0.0004873 46.0
TLS2_k127_2917387_7 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 413.0
TLS2_k127_2917387_8 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 386.0
TLS2_k127_2917387_9 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 386.0
TLS2_k127_2927707_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - - 0.0 1017.0
TLS2_k127_2927707_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 6.062e-206 672.0
TLS2_k127_2927707_10 domain protein - - - 0.0000000000000000000000984 113.0
TLS2_k127_2927707_11 translation release factor activity K03265 - - 0.000000000000000001519 98.0
TLS2_k127_2927707_12 Bacterial Ig-like domain 2 - - - 0.000000000001981 80.0
TLS2_k127_2927707_2 RNA-metabolising metallo-beta-lactamase K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 535.0
TLS2_k127_2927707_3 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 425.0
TLS2_k127_2927707_4 Hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 399.0
TLS2_k127_2927707_5 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 346.0
TLS2_k127_2927707_6 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 359.0
TLS2_k127_2927707_7 Formate/nitrite transporter K06212 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 321.0
TLS2_k127_2927707_8 PAS fold - - - 0.000000000000000000000000000000000000000000000000000001717 200.0
TLS2_k127_2927707_9 AI-2E family transporter - - - 0.0000000000000000000000000000000000000006733 164.0
TLS2_k127_2995385_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 3487.0
TLS2_k127_2995385_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1135.0
TLS2_k127_2995385_10 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006248 607.0
TLS2_k127_2995385_100 LemA family K03744 - - 0.000000000000000000000000004404 118.0
TLS2_k127_2995385_101 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000001856 112.0
TLS2_k127_2995385_102 - - - - 0.00000000000000000000000009258 117.0
TLS2_k127_2995385_103 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000001742 115.0
TLS2_k127_2995385_104 amine dehydrogenase activity - - - 0.000000000000000000000000933 121.0
TLS2_k127_2995385_105 Belongs to the bacterial solute-binding protein 9 family - - - 0.000000000000000000000003388 120.0
TLS2_k127_2995385_106 NIPSNAP - - - 0.00000000000000000000003104 102.0
TLS2_k127_2995385_107 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000000004723 104.0
TLS2_k127_2995385_108 - - - - 0.000000000000000000004147 101.0
TLS2_k127_2995385_109 transcriptional regulators - - - 0.0000000000000000001074 96.0
TLS2_k127_2995385_11 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 605.0
TLS2_k127_2995385_110 COGs COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system K06218 - - 0.000000000000000000278 89.0
TLS2_k127_2995385_111 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000005736 89.0
TLS2_k127_2995385_112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000004404 90.0
TLS2_k127_2995385_113 Histidine kinase - - - 0.00000000000000002745 87.0
TLS2_k127_2995385_114 negative regulation of transcription, DNA-templated - - - 0.00000000000000003534 87.0
TLS2_k127_2995385_115 ABC transporter K10112 - - 0.00000000000000008033 84.0
TLS2_k127_2995385_116 phosphorelay signal transduction system K02477,K07705,K08083,K11641 - - 0.00000000000000008165 85.0
TLS2_k127_2995385_117 Belongs to the amidase family K01426 - 3.5.1.4 0.0000000000000003441 82.0
TLS2_k127_2995385_118 WD40 domain protein beta Propeller - - - 0.0000000000000006271 92.0
TLS2_k127_2995385_12 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 570.0
TLS2_k127_2995385_120 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000005754 80.0
TLS2_k127_2995385_121 - - - - 0.0000000000007203 83.0
TLS2_k127_2995385_122 - - - - 0.000000000004449 79.0
TLS2_k127_2995385_123 domain protein - - - 0.00000000001128 79.0
TLS2_k127_2995385_125 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.000000005574 67.0
TLS2_k127_2995385_126 - - - - 0.000000008372 63.0
TLS2_k127_2995385_127 Domain of unknown function (DUF4440) - - - 0.00000002362 63.0
TLS2_k127_2995385_128 protein kinase activity - - - 0.00000003296 64.0
TLS2_k127_2995385_129 protein kinase activity K08884 - 2.7.11.1 0.00000003856 59.0
TLS2_k127_2995385_13 Putative modulator of DNA gyrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000658 547.0
TLS2_k127_2995385_130 PBS lyase HEAT-like repeat - - - 0.00000004179 66.0
TLS2_k127_2995385_131 - - - - 0.0000001559 62.0
TLS2_k127_2995385_132 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.0000003669 62.0
TLS2_k127_2995385_133 PDZ DHR GLGF domain protein - - - 0.0000005188 63.0
TLS2_k127_2995385_134 Plasmid stabilization system K19092 - - 0.000001824 53.0
TLS2_k127_2995385_135 Amidohydrolase family - - - 0.000004534 58.0
TLS2_k127_2995385_136 - - - - 0.00001137 57.0
TLS2_k127_2995385_137 - - - - 0.00004392 51.0
TLS2_k127_2995385_138 PFAM Abortive infection protein K07052 - - 0.00005559 54.0
TLS2_k127_2995385_139 Domain of unknown function (DUF4440) - - - 0.00006274 54.0
TLS2_k127_2995385_14 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 566.0
TLS2_k127_2995385_140 protein kinase activity - - - 0.0004353 44.0
TLS2_k127_2995385_15 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000594 530.0
TLS2_k127_2995385_16 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 533.0
TLS2_k127_2995385_17 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 529.0
TLS2_k127_2995385_18 Y_Y_Y domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 542.0
TLS2_k127_2995385_19 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 524.0
TLS2_k127_2995385_2 Dehydrogenase K15371 - 1.4.1.2 7.572e-295 963.0
TLS2_k127_2995385_20 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 520.0
TLS2_k127_2995385_21 FAD dependent oxidoreductase K19813 - 1.1.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 492.0
TLS2_k127_2995385_22 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 488.0
TLS2_k127_2995385_23 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 461.0
TLS2_k127_2995385_24 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 433.0
TLS2_k127_2995385_25 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 434.0
TLS2_k127_2995385_26 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009937 443.0
TLS2_k127_2995385_27 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 416.0
TLS2_k127_2995385_28 Domain of unknown function (DUF4143) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 416.0
TLS2_k127_2995385_29 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 408.0
TLS2_k127_2995385_3 peptidase S9B dipeptidylpeptidase IV domain protein - - - 9.03e-291 914.0
TLS2_k127_2995385_30 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 426.0
TLS2_k127_2995385_31 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007435 398.0
TLS2_k127_2995385_32 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 425.0
TLS2_k127_2995385_33 Sulfatase K01138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006203 411.0
TLS2_k127_2995385_34 DNA/RNA non-specific endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 427.0
TLS2_k127_2995385_35 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 397.0
TLS2_k127_2995385_36 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 410.0
TLS2_k127_2995385_37 COG1002 Type II restriction enzyme, methylase subunits - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 391.0
TLS2_k127_2995385_38 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 381.0
TLS2_k127_2995385_39 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 398.0
TLS2_k127_2995385_4 protein kinase activity - - - 5.981e-280 886.0
TLS2_k127_2995385_40 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 398.0
TLS2_k127_2995385_41 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005791 349.0
TLS2_k127_2995385_42 TIGRFAM phenazine biosynthesis protein PhzF family K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006697 358.0
TLS2_k127_2995385_43 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 297.0
TLS2_k127_2995385_44 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 316.0
TLS2_k127_2995385_45 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004452 298.0
TLS2_k127_2995385_46 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 314.0
TLS2_k127_2995385_47 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 305.0
TLS2_k127_2995385_48 RES domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007533 290.0
TLS2_k127_2995385_49 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 294.0
TLS2_k127_2995385_5 Histidine kinase - - - 2.36e-268 875.0
TLS2_k127_2995385_50 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004937 290.0
TLS2_k127_2995385_51 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007849 268.0
TLS2_k127_2995385_52 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001911 287.0
TLS2_k127_2995385_53 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000003585 276.0
TLS2_k127_2995385_54 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001395 286.0
TLS2_k127_2995385_55 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002242 273.0
TLS2_k127_2995385_56 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000004959 237.0
TLS2_k127_2995385_57 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001834 245.0
TLS2_k127_2995385_58 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000003144 241.0
TLS2_k127_2995385_59 Phosphorylase superfamily K11783 - 3.2.2.26 0.0000000000000000000000000000000000000000000000000000000000000001246 229.0
TLS2_k127_2995385_6 efflux transmembrane transporter activity - - - 3.223e-257 827.0
TLS2_k127_2995385_60 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000002044 247.0
TLS2_k127_2995385_61 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000009538 223.0
TLS2_k127_2995385_62 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000001101 216.0
TLS2_k127_2995385_63 Bacterial transcriptional repressor C-terminal K16137 - - 0.000000000000000000000000000000000000000000000000000000000004984 214.0
TLS2_k127_2995385_64 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000001119 215.0
TLS2_k127_2995385_65 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000001673 228.0
TLS2_k127_2995385_66 - - - - 0.00000000000000000000000000000000000000000000000000000001632 213.0
TLS2_k127_2995385_67 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000008026 199.0
TLS2_k127_2995385_68 - - - - 0.00000000000000000000000000000000000000000000000000005039 195.0
TLS2_k127_2995385_69 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000005333 197.0
TLS2_k127_2995385_7 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 6.396e-196 620.0
TLS2_k127_2995385_70 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000008146 203.0
TLS2_k127_2995385_71 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000008748 201.0
TLS2_k127_2995385_72 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000004139 183.0
TLS2_k127_2995385_73 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000000000000000000000000000000000004246 191.0
TLS2_k127_2995385_74 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000003301 190.0
TLS2_k127_2995385_75 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000000000008688 176.0
TLS2_k127_2995385_76 Sigma-70, region 4 K02405 - - 0.000000000000000000000000000000000000000000000001461 186.0
TLS2_k127_2995385_77 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.000000000000000000000000000000000000000000000002157 200.0
TLS2_k127_2995385_78 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000001247 167.0
TLS2_k127_2995385_79 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.00000000000000000000000000000000000000000001654 171.0
TLS2_k127_2995385_8 pyrroloquinoline quinone binding - - - 6.531e-194 618.0
TLS2_k127_2995385_80 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000000000004496 163.0
TLS2_k127_2995385_81 Protein of unknown function (DUF2384) - - - 0.0000000000000000000000000000000000000000002389 162.0
TLS2_k127_2995385_82 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000002839 162.0
TLS2_k127_2995385_83 protein kinase activity - - - 0.000000000000000000000000000000000000000004072 158.0
TLS2_k127_2995385_85 Peptidase family S41 - - - 0.00000000000000000000000000000000000000002164 171.0
TLS2_k127_2995385_86 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000001406 173.0
TLS2_k127_2995385_87 - - - - 0.000000000000000000000000000000000000005731 158.0
TLS2_k127_2995385_88 Antirepressor regulating drug resistance - - - 0.00000000000000000000000000000000000002019 163.0
TLS2_k127_2995385_89 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000006226 147.0
TLS2_k127_2995385_9 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008388 606.0
TLS2_k127_2995385_90 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000006387 142.0
TLS2_k127_2995385_91 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000008296 146.0
TLS2_k127_2995385_92 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000004229 148.0
TLS2_k127_2995385_93 chemotaxis signal transduction protein K03408 - - 0.000000000000000000000000000000000005729 146.0
TLS2_k127_2995385_94 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000001883 135.0
TLS2_k127_2995385_95 PFAM ATP-binding region, ATPase domain protein K07709 - 2.7.13.3 0.000000000000000000000000000000002449 146.0
TLS2_k127_2995385_96 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000004058 131.0
TLS2_k127_2995385_97 endonuclease exonuclease phosphatase K07004 - - 0.0000000000000000000000000000001043 145.0
TLS2_k127_2995385_98 Domain of unknown function (DUF5122) beta-propeller - - - 0.000000000000000000000000000001913 141.0
TLS2_k127_2995385_99 phosphate ion binding K02040 - - 0.000000000000000000000000001513 117.0
TLS2_k127_3034136_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 1.676e-312 981.0
TLS2_k127_3034136_1 xanthine dehydrogenase activity - - - 6.815e-297 928.0
TLS2_k127_3034136_10 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 590.0
TLS2_k127_3034136_100 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000008724 150.0
TLS2_k127_3034136_101 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000001532 149.0
TLS2_k127_3034136_102 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000005642 147.0
TLS2_k127_3034136_103 allantoin biosynthetic process K01477,K16840 - 3.5.3.4,4.1.1.97 0.0000000000000000000000000000000000004119 146.0
TLS2_k127_3034136_104 hydroxyisourate hydrolase activity K07127,K13485 GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009112,GO:0009987,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.2.17,4.1.1.97 0.000000000000000000000000000000000001591 143.0
TLS2_k127_3034136_105 Aldehyde oxidase and xanthine dehydrogenase - - - 0.000000000000000000000000000000000001658 143.0
TLS2_k127_3034136_106 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000006937 140.0
TLS2_k127_3034136_107 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000005112 150.0
TLS2_k127_3034136_108 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000005226 143.0
TLS2_k127_3034136_109 YceI-like domain - - - 0.0000000000000000000000000000000002059 139.0
TLS2_k127_3034136_11 Nitronate monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 588.0
TLS2_k127_3034136_110 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000002291 138.0
TLS2_k127_3034136_111 Penicillinase repressor - - - 0.0000000000000000000000000000000009809 134.0
TLS2_k127_3034136_112 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000006185 132.0
TLS2_k127_3034136_113 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000001434 129.0
TLS2_k127_3034136_114 Transcriptional regulator - - - 0.00000000000000000000000000000341 132.0
TLS2_k127_3034136_115 ATP-independent chaperone mediated protein folding - - - 0.000000000000000000000000000003695 127.0
TLS2_k127_3034136_116 efflux transmembrane transporter activity - - - 0.000000000000000000000000000006198 126.0
TLS2_k127_3034136_117 - - - - 0.000000000000000000000000000007421 126.0
TLS2_k127_3034136_118 protein flavinylation K03734 - 2.7.1.180 0.00000000000000000000000000001981 132.0
TLS2_k127_3034136_119 cyclic nucleotide binding K10914,K21563 - - 0.00000000000000000000000000003808 124.0
TLS2_k127_3034136_12 KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009214 576.0
TLS2_k127_3034136_120 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000005077 128.0
TLS2_k127_3034136_121 AlkA N-terminal domain K13529 - 3.2.2.21 0.00000000000000000000000000006498 120.0
TLS2_k127_3034136_122 regulation of RNA biosynthetic process K03655 - 3.6.4.12 0.0000000000000000000000000001518 126.0
TLS2_k127_3034136_123 PFAM Abortive infection protein K07052 - - 0.0000000000000000000000000002162 126.0
TLS2_k127_3034136_124 - - - - 0.0000000000000000000000000002405 133.0
TLS2_k127_3034136_125 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000005893 121.0
TLS2_k127_3034136_126 Putative stress-induced transcription regulator - - - 0.000000000000000000000000001114 121.0
TLS2_k127_3034136_127 FCD domain - - - 0.000000000000000000000000001588 120.0
TLS2_k127_3034136_128 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000005096 121.0
TLS2_k127_3034136_129 glyoxalase III activity - - - 0.00000000000000000000000002044 122.0
TLS2_k127_3034136_13 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 565.0
TLS2_k127_3034136_130 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000031 111.0
TLS2_k127_3034136_131 arsR family transcriptional regulator - - - 0.00000000000000000000000003265 117.0
TLS2_k127_3034136_132 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000004412 113.0
TLS2_k127_3034136_133 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000004436 111.0
TLS2_k127_3034136_134 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.0000000000000000000000007332 118.0
TLS2_k127_3034136_135 - - - - 0.000000000000000000000004565 108.0
TLS2_k127_3034136_136 Regulatory protein MarR - - - 0.000000000000000000000004822 108.0
TLS2_k127_3034136_137 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000001864 104.0
TLS2_k127_3034136_138 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000001907 101.0
TLS2_k127_3034136_139 PFAM glycoside hydrolase family 13 domain protein - - - 0.0000000000000000000005373 106.0
TLS2_k127_3034136_14 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 544.0
TLS2_k127_3034136_140 PFAM beta-lactamase - - - 0.0000000000000000000006314 109.0
TLS2_k127_3034136_141 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000001084 109.0
TLS2_k127_3034136_142 YCII-related domain - - - 0.000000000000000000003708 96.0
TLS2_k127_3034136_143 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000009509 93.0
TLS2_k127_3034136_144 negative regulation of transcription, DNA-templated - - - 0.0000000000000000004866 91.0
TLS2_k127_3034136_145 peptidoglycan-binding protein, lysm - - - 0.0000000000000000006931 91.0
TLS2_k127_3034136_146 Beta-lactamase - - - 0.0000000000000000007366 96.0
TLS2_k127_3034136_147 Penicillinase repressor - - - 0.000000000000000001713 90.0
TLS2_k127_3034136_148 BlaR1 peptidase M56 - - - 0.000000000000000003253 97.0
TLS2_k127_3034136_149 - - - - 0.000000000000000003994 92.0
TLS2_k127_3034136_15 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 520.0
TLS2_k127_3034136_150 - - - - 0.00000000000000002195 93.0
TLS2_k127_3034136_151 Bacterial transcriptional activator domain - - - 0.00000000000000007582 96.0
TLS2_k127_3034136_152 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.00000000000000007909 92.0
TLS2_k127_3034136_153 Transcriptional regulator PadR-like family - - - 0.0000000000000001307 84.0
TLS2_k127_3034136_154 - - - - 0.0000000000000005065 89.0
TLS2_k127_3034136_155 - - - - 0.000000000000004009 80.0
TLS2_k127_3034136_156 Transcriptional regulator PadR-like family - - - 0.00000000000007161 76.0
TLS2_k127_3034136_157 PFAM blue (type 1) copper domain protein K00368,K07243 - 1.7.2.1 0.0000000000001079 79.0
TLS2_k127_3034136_158 - - - - 0.0000000000001153 83.0
TLS2_k127_3034136_16 cystathionine K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 508.0
TLS2_k127_3034136_160 Bor protein - - - 0.000000000001644 73.0
TLS2_k127_3034136_161 YCII-related domain - - - 0.000000000002576 74.0
TLS2_k127_3034136_162 Transcriptional regulator, GntR family - - - 0.000000000002921 77.0
TLS2_k127_3034136_163 phosphorelay signal transduction system K07670 - - 0.00000000001016 66.0
TLS2_k127_3034136_164 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000005476 74.0
TLS2_k127_3034136_165 response regulator - - - 0.00000000006634 74.0
TLS2_k127_3034136_167 PFAM polysaccharide export protein K01991 - - 0.0000000002625 72.0
TLS2_k127_3034136_168 Major Facilitator Superfamily - - - 0.0000000004769 67.0
TLS2_k127_3034136_169 - - - - 0.00000001324 66.0
TLS2_k127_3034136_17 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 529.0
TLS2_k127_3034136_170 NHL repeat - - - 0.0000000163 66.0
TLS2_k127_3034136_171 amine dehydrogenase activity - - - 0.00000005883 64.0
TLS2_k127_3034136_172 Putative adhesin - - - 0.00000006636 64.0
TLS2_k127_3034136_173 Copper binding proteins, plastocyanin/azurin family - - - 0.0000002501 62.0
TLS2_k127_3034136_174 cell redox homeostasis - - - 0.000001494 62.0
TLS2_k127_3034136_175 - - - - 0.000002292 58.0
TLS2_k127_3034136_176 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00001041 57.0
TLS2_k127_3034136_177 6-bladed beta-propeller - - - 0.00001253 57.0
TLS2_k127_3034136_18 Belongs to the HpcH HpaI aldolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 490.0
TLS2_k127_3034136_180 Tetratricopeptide repeat - - - 0.0002922 49.0
TLS2_k127_3034136_181 PFAM Spore germination protein-like Gmad2, bacteria - - - 0.0003126 51.0
TLS2_k127_3034136_19 allantoinase K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 477.0
TLS2_k127_3034136_2 GMC oxidoreductase - - - 4.172e-280 870.0
TLS2_k127_3034136_20 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000329 460.0
TLS2_k127_3034136_21 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 472.0
TLS2_k127_3034136_22 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007436 456.0
TLS2_k127_3034136_23 Flavoprotein involved in K transport K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 443.0
TLS2_k127_3034136_24 Penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 441.0
TLS2_k127_3034136_25 Belongs to the allantoicase family K01477 GO:0003674,GO:0003824,GO:0004037,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 419.0
TLS2_k127_3034136_26 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 410.0
TLS2_k127_3034136_27 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006877 385.0
TLS2_k127_3034136_28 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 387.0
TLS2_k127_3034136_29 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 399.0
TLS2_k127_3034136_3 Carbohydrate family 9 binding domain-like - - - 5.749e-260 827.0
TLS2_k127_3034136_30 Thioesterase-like superfamily K10805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 369.0
TLS2_k127_3034136_31 Sigma-70 region 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 371.0
TLS2_k127_3034136_32 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 364.0
TLS2_k127_3034136_33 - K01286 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 365.0
TLS2_k127_3034136_34 VWA domain containing CoxE-like protein K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 364.0
TLS2_k127_3034136_35 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 345.0
TLS2_k127_3034136_36 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000719 329.0
TLS2_k127_3034136_37 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 347.0
TLS2_k127_3034136_38 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 336.0
TLS2_k127_3034136_39 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 311.0
TLS2_k127_3034136_4 MacB-like periplasmic core domain - - - 7.017e-250 799.0
TLS2_k127_3034136_40 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 311.0
TLS2_k127_3034136_41 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 302.0
TLS2_k127_3034136_42 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 286.0
TLS2_k127_3034136_43 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002146 282.0
TLS2_k127_3034136_44 response to abiotic stimulus K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001076 282.0
TLS2_k127_3034136_45 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003198 289.0
TLS2_k127_3034136_46 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000287 275.0
TLS2_k127_3034136_47 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000002587 264.0
TLS2_k127_3034136_48 peroxidase activity K00435 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002815 267.0
TLS2_k127_3034136_49 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009042 275.0
TLS2_k127_3034136_5 TonB-dependent receptor - - - 1.275e-240 782.0
TLS2_k127_3034136_50 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005629 260.0
TLS2_k127_3034136_51 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000935 282.0
TLS2_k127_3034136_52 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001429 283.0
TLS2_k127_3034136_53 Prolyl oligopeptidase family K01303 - 3.4.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001585 279.0
TLS2_k127_3034136_54 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002067 265.0
TLS2_k127_3034136_55 Rhodanese Homology Domain K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000002709 257.0
TLS2_k127_3034136_56 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006896 254.0
TLS2_k127_3034136_57 Belongs to the AB hydrolase superfamily. MetX family K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000001172 252.0
TLS2_k127_3034136_58 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004549 266.0
TLS2_k127_3034136_59 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004978 247.0
TLS2_k127_3034136_6 efflux transmembrane transporter activity - - - 7.143e-237 764.0
TLS2_k127_3034136_60 heme binding K08642,K21472 - - 0.000000000000000000000000000000000000000000000000000000000000000000003765 256.0
TLS2_k127_3034136_61 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000006452 234.0
TLS2_k127_3034136_62 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001125 239.0
TLS2_k127_3034136_63 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000001588 244.0
TLS2_k127_3034136_64 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000009417 252.0
TLS2_k127_3034136_65 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001513 235.0
TLS2_k127_3034136_66 Domain of unknown function (DUF4287) - - - 0.00000000000000000000000000000000000000000000000000000000000000038 225.0
TLS2_k127_3034136_67 Mo-molybdopterin cofactor metabolic process K21572 - - 0.000000000000000000000000000000000000000000000000000000000000003219 238.0
TLS2_k127_3034136_68 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000002028 237.0
TLS2_k127_3034136_69 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000002151 225.0
TLS2_k127_3034136_7 Zinc carboxypeptidase - - - 1.899e-209 684.0
TLS2_k127_3034136_70 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000002379 223.0
TLS2_k127_3034136_72 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000007285 211.0
TLS2_k127_3034136_73 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000001984 215.0
TLS2_k127_3034136_74 Cytidine and deoxycytidylate deaminase zinc-binding region - - - 0.000000000000000000000000000000000000000000000000000000002179 209.0
TLS2_k127_3034136_75 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000001511 197.0
TLS2_k127_3034136_76 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000001055 199.0
TLS2_k127_3034136_77 dehydrogenases and related proteins - - - 0.00000000000000000000000000000000000000000000000000001059 207.0
TLS2_k127_3034136_78 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000003619 203.0
TLS2_k127_3034136_79 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000007225 196.0
TLS2_k127_3034136_8 PFAM nucleoside H symporter - - - 1.275e-201 634.0
TLS2_k127_3034136_80 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000000000000000000000000000000000003607 189.0
TLS2_k127_3034136_81 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000005443 200.0
TLS2_k127_3034136_82 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000001159 192.0
TLS2_k127_3034136_83 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000008863 181.0
TLS2_k127_3034136_84 Cysteine-rich motif following a subset of SET domains K07117 - - 0.000000000000000000000000000000000000000000000005032 179.0
TLS2_k127_3034136_85 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000002324 177.0
TLS2_k127_3034136_86 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000006949 168.0
TLS2_k127_3034136_87 Calcium/calmodulin dependent protein kinase II association domain - - - 0.000000000000000000000000000000000000000000001314 171.0
TLS2_k127_3034136_88 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000000000000000000000000000341 166.0
TLS2_k127_3034136_89 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000000223 166.0
TLS2_k127_3034136_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 616.0
TLS2_k127_3034136_90 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000003387 169.0
TLS2_k127_3034136_91 domain, Protein - - - 0.00000000000000000000000000000000000000000008281 184.0
TLS2_k127_3034136_92 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000004877 160.0
TLS2_k127_3034136_93 sequence-specific DNA binding K03719 - - 0.0000000000000000000000000000000000000000009504 161.0
TLS2_k127_3034136_94 Conserved hypothetical protein (DUF2461) - - - 0.000000000000000000000000000000000000000001159 165.0
TLS2_k127_3034136_95 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000006137 169.0
TLS2_k127_3034136_96 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000000000000000007505 160.0
TLS2_k127_3034136_97 helix_turn_helix multiple antibiotic resistance protein K15973 - - 0.00000000000000000000000000000000000000001052 162.0
TLS2_k127_3034136_98 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000003297 164.0
TLS2_k127_3034136_99 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000001318 151.0
TLS2_k127_3162356_0 Glucose / Sorbosone dehydrogenase - - - 1.331e-198 630.0
TLS2_k127_3162356_1 Belongs to the GARS family K01945,K13713 GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.000000000000000000000000000000000000000000000000000006352 192.0
TLS2_k127_3162356_2 - - - - 0.000000000000000441 82.0
TLS2_k127_3162356_3 polyhydroxyalkanoic acid - - - 0.00000000000005435 76.0
TLS2_k127_3162356_4 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0009801 50.0
TLS2_k127_3248589_0 Methionine synthase B12-binding module cap domain protein K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1277.0
TLS2_k127_3248589_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 6.089e-206 657.0
TLS2_k127_3248589_2 23S rRNA-intervening sequence protein - - - 0.0000009125 58.0
TLS2_k127_3410815_0 NADH:flavin oxidoreductase / NADH oxidase family K09461 - 1.14.13.40 0.0 1058.0
TLS2_k127_3410815_1 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1015.0
TLS2_k127_3410815_10 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 516.0
TLS2_k127_3410815_100 Prophage tail length tape measure protein - - - 0.00001493 58.0
TLS2_k127_3410815_101 Endonuclease/Exonuclease/phosphatase family - - - 0.00005129 55.0
TLS2_k127_3410815_102 Lytic transglycosylase catalytic K08309 - - 0.0002238 52.0
TLS2_k127_3410815_11 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 494.0
TLS2_k127_3410815_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 493.0
TLS2_k127_3410815_13 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 494.0
TLS2_k127_3410815_14 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 488.0
TLS2_k127_3410815_15 DNA alkylation repair - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 485.0
TLS2_k127_3410815_16 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 476.0
TLS2_k127_3410815_17 Uncharacterised protein family (UPF0182) K09118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000842 499.0
TLS2_k127_3410815_18 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 468.0
TLS2_k127_3410815_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 461.0
TLS2_k127_3410815_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 8.712e-248 777.0
TLS2_k127_3410815_20 Phosphoglycerate kinase K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 456.0
TLS2_k127_3410815_21 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 446.0
TLS2_k127_3410815_22 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 444.0
TLS2_k127_3410815_23 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 438.0
TLS2_k127_3410815_24 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007348 410.0
TLS2_k127_3410815_25 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007447 411.0
TLS2_k127_3410815_26 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 406.0
TLS2_k127_3410815_27 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 398.0
TLS2_k127_3410815_28 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 396.0
TLS2_k127_3410815_29 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 395.0
TLS2_k127_3410815_3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 8.795e-214 685.0
TLS2_k127_3410815_30 Phospholipase D. Active site motifs. K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 390.0
TLS2_k127_3410815_31 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 386.0
TLS2_k127_3410815_32 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 386.0
TLS2_k127_3410815_33 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 384.0
TLS2_k127_3410815_34 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 375.0
TLS2_k127_3410815_35 SIS domain K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 381.0
TLS2_k127_3410815_36 Fumarate reductase, iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 368.0
TLS2_k127_3410815_37 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 373.0
TLS2_k127_3410815_38 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 353.0
TLS2_k127_3410815_39 DAHP synthetase I family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006391 316.0
TLS2_k127_3410815_4 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 1.3e-207 662.0
TLS2_k127_3410815_40 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 297.0
TLS2_k127_3410815_41 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005554 303.0
TLS2_k127_3410815_42 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 298.0
TLS2_k127_3410815_43 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008255 287.0
TLS2_k127_3410815_44 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001097 291.0
TLS2_k127_3410815_45 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001046 274.0
TLS2_k127_3410815_46 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000002897 271.0
TLS2_k127_3410815_47 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005517 286.0
TLS2_k127_3410815_48 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001001 266.0
TLS2_k127_3410815_49 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001067 261.0
TLS2_k127_3410815_5 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 612.0
TLS2_k127_3410815_50 Peptidase C26 K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000001245 256.0
TLS2_k127_3410815_51 Bacterial membrane protein YfhO - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006173 278.0
TLS2_k127_3410815_52 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000001451 255.0
TLS2_k127_3410815_53 - K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000000009876 234.0
TLS2_k127_3410815_54 Biotin/lipoate A/B protein ligase family K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000007975 220.0
TLS2_k127_3410815_55 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000008025 225.0
TLS2_k127_3410815_56 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000003725 216.0
TLS2_k127_3410815_57 NDK K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000002707 199.0
TLS2_k127_3410815_58 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000002327 200.0
TLS2_k127_3410815_59 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.000000000000000000000000000000000000000000000000000007234 194.0
TLS2_k127_3410815_6 NAD synthase K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 596.0
TLS2_k127_3410815_60 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000114 194.0
TLS2_k127_3410815_61 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - 0.0000000000000000000000000000000000000000000000001636 190.0
TLS2_k127_3410815_62 integral membrane protein - - - 0.0000000000000000000000000000000000000000000000002303 183.0
TLS2_k127_3410815_63 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000001442 192.0
TLS2_k127_3410815_64 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000167 195.0
TLS2_k127_3410815_65 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000007369 180.0
TLS2_k127_3410815_66 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000007634 174.0
TLS2_k127_3410815_67 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000001382 185.0
TLS2_k127_3410815_68 LemA family K03744 - - 0.0000000000000000000000000000000000000000007047 166.0
TLS2_k127_3410815_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 576.0
TLS2_k127_3410815_70 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000003853 149.0
TLS2_k127_3410815_71 TPM domain K06872 - - 0.000000000000000000000000000000001112 141.0
TLS2_k127_3410815_72 PFAM molybdopterin biosynthesis MoaE protein K03635,K21142 - 2.8.1.12 0.000000000000000000000000000000001532 134.0
TLS2_k127_3410815_73 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000785 134.0
TLS2_k127_3410815_74 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000104 134.0
TLS2_k127_3410815_76 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000000000002338 125.0
TLS2_k127_3410815_77 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000007149 127.0
TLS2_k127_3410815_78 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000001433 120.0
TLS2_k127_3410815_79 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 0.0000000000000000000000000002217 119.0
TLS2_k127_3410815_8 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000696 532.0
TLS2_k127_3410815_80 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000000004629 117.0
TLS2_k127_3410815_81 Alpha beta hydrolase - - - 0.0000000000000000000000000005143 124.0
TLS2_k127_3410815_82 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000000001066 113.0
TLS2_k127_3410815_83 competence protein - - - 0.00000000000000000000000005778 120.0
TLS2_k127_3410815_84 TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000002969 120.0
TLS2_k127_3410815_85 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000005491 105.0
TLS2_k127_3410815_86 - - - - 0.0000000000000000000001107 114.0
TLS2_k127_3410815_87 Sigma-70 region 2 K03088 - - 0.000000000000000000002781 100.0
TLS2_k127_3410815_88 RNA polymerase sigma factor K03088 - - 0.0000000000000000001371 99.0
TLS2_k127_3410815_89 Preprotein translocase SecG subunit K03075 - - 0.00000000000000001153 88.0
TLS2_k127_3410815_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 515.0
TLS2_k127_3410815_90 nucleotidyltransferase activity - - - 0.0000000000000003306 89.0
TLS2_k127_3410815_91 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000005292 90.0
TLS2_k127_3410815_92 structural constituent of ribosome K02911 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000008331 78.0
TLS2_k127_3410815_93 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000001124 82.0
TLS2_k127_3410815_94 Mo-molybdopterin cofactor metabolic process K03636,K03637,K03752,K21142 - 2.7.7.77,2.8.1.12,4.6.1.17 0.000000005398 60.0
TLS2_k127_3410815_95 Transcriptional regulator, GntR family K03710 - - 0.000000006782 69.0
TLS2_k127_3410815_96 Domain of Unknown function (DUF542) K07322 GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564 - 0.000001903 55.0
TLS2_k127_3410815_97 Methionine biosynthesis protein MetW - - - 0.000003771 58.0
TLS2_k127_3410815_98 Lipopolysaccharide-assembly, LptC-related - - - 0.000005234 56.0
TLS2_k127_3410815_99 Peptidase S24-like - - - 0.0000138 49.0
TLS2_k127_3489902_0 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 473.0
TLS2_k127_3489902_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 408.0
TLS2_k127_3489902_2 Bacterial regulatory protein, Fis family K10912 - - 0.0000000002006 66.0
TLS2_k127_3561293_0 Isocitrate dehydrogenase NADP-dependent, monomeric type K00031 - 1.1.1.42 0.0 1046.0
TLS2_k127_3561293_1 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 2.381e-294 920.0
TLS2_k127_3561293_10 SigmaW regulon antibacterial - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 422.0
TLS2_k127_3561293_11 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005465 403.0
TLS2_k127_3561293_12 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 413.0
TLS2_k127_3561293_13 mechanosensitive ion channel K16053 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 410.0
TLS2_k127_3561293_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009307 401.0
TLS2_k127_3561293_15 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 360.0
TLS2_k127_3561293_16 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 349.0
TLS2_k127_3561293_17 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005897 366.0
TLS2_k127_3561293_18 Membrane-bound serine protease (ClpP class) K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 320.0
TLS2_k127_3561293_19 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 318.0
TLS2_k127_3561293_2 Penicillin amidase - - - 2.758e-274 873.0
TLS2_k127_3561293_20 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 307.0
TLS2_k127_3561293_21 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 292.0
TLS2_k127_3561293_22 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000122 285.0
TLS2_k127_3561293_23 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001604 282.0
TLS2_k127_3561293_24 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008702 274.0
TLS2_k127_3561293_25 Response regulator receiver K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002903 268.0
TLS2_k127_3561293_26 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003793 266.0
TLS2_k127_3561293_27 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003897 258.0
TLS2_k127_3561293_28 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000928 271.0
TLS2_k127_3561293_29 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001569 249.0
TLS2_k127_3561293_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 3.932e-274 852.0
TLS2_k127_3561293_30 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000008865 235.0
TLS2_k127_3561293_31 LemA family - - - 0.000000000000000000000000000000000000000000000000000000000000000007272 229.0
TLS2_k127_3561293_32 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000009631 208.0
TLS2_k127_3561293_33 - - - - 0.000000000000000000000000000000000000000000002144 172.0
TLS2_k127_3561293_34 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000008496 154.0
TLS2_k127_3561293_35 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000002573 156.0
TLS2_k127_3561293_36 - - - - 0.000000000000000000000000000000000000001839 159.0
TLS2_k127_3561293_37 Pfam Zn-finger in ubiquitin-hydrolases and other protein K03455 - - 0.00000000000000000000000000000000000002711 147.0
TLS2_k127_3561293_38 Domain of unknown function (DUF4212) - - - 0.0000000000000000000000000000004991 130.0
TLS2_k127_3561293_39 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000007891 124.0
TLS2_k127_3561293_4 Outer membrane protein beta-barrel family - - - 4.934e-263 834.0
TLS2_k127_3561293_40 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 0.00000000000000000000000001282 110.0
TLS2_k127_3561293_42 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000004767 91.0
TLS2_k127_3561293_45 Putative adhesin - - - 0.00000000000000004182 93.0
TLS2_k127_3561293_46 - - - - 0.0005513 51.0
TLS2_k127_3561293_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 5.58e-202 639.0
TLS2_k127_3561293_6 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009434 578.0
TLS2_k127_3561293_7 Cation transport protein K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 574.0
TLS2_k127_3561293_8 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 516.0
TLS2_k127_3561293_9 Belongs to the thiolase family K00626,K07823 - 2.3.1.174,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005812 449.0
TLS2_k127_3585297_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 610.0
TLS2_k127_3585297_1 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 565.0
TLS2_k127_3585297_10 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 325.0
TLS2_k127_3585297_11 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009546 299.0
TLS2_k127_3585297_12 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001459 301.0
TLS2_k127_3585297_13 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009729 279.0
TLS2_k127_3585297_14 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000004659 265.0
TLS2_k127_3585297_15 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000008046 244.0
TLS2_k127_3585297_16 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000003662 107.0
TLS2_k127_3585297_17 - - - - 0.000000000000000000001045 99.0
TLS2_k127_3585297_18 Cell division protein FtsQ K03589 - - 0.000000000000000001051 95.0
TLS2_k127_3585297_19 Putative glutamine amidotransferase - - - 0.000000000000000427 93.0
TLS2_k127_3585297_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 493.0
TLS2_k127_3585297_20 - K22022 GO:0002218,GO:0002220,GO:0002223,GO:0002253,GO:0002376,GO:0002429,GO:0002682,GO:0002684,GO:0002757,GO:0002758,GO:0002764,GO:0002768,GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005796,GO:0005886,GO:0006457,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0007154,GO:0007162,GO:0007165,GO:0007166,GO:0007267,GO:0007268,GO:0007271,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0010467,GO:0012505,GO:0016020,GO:0016021,GO:0016266,GO:0019538,GO:0022407,GO:0022408,GO:0022417,GO:0023052,GO:0030155,GO:0031224,GO:0031347,GO:0031349,GO:0031974,GO:0033036,GO:0033130,GO:0034394,GO:0034613,GO:0034645,GO:0036211,GO:0036477,GO:0042995,GO:0043005,GO:0043025,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051179,GO:0051604,GO:0051641,GO:0051716,GO:0061077,GO:0065007,GO:0070013,GO:0070085,GO:0070727,GO:0071704,GO:0071944,GO:0080134,GO:0097458,GO:0098916,GO:0099536,GO:0099537,GO:0120025,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.000001584 57.0
TLS2_k127_3585297_21 - - - - 0.0008026 49.0
TLS2_k127_3585297_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 481.0
TLS2_k127_3585297_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 402.0
TLS2_k127_3585297_5 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 414.0
TLS2_k127_3585297_6 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 401.0
TLS2_k127_3585297_7 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 395.0
TLS2_k127_3585297_8 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 366.0
TLS2_k127_3585297_9 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007566 359.0
TLS2_k127_3648206_0 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0 1084.0
TLS2_k127_3648206_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 4.085e-244 782.0
TLS2_k127_3648206_10 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007345 525.0
TLS2_k127_3648206_100 COG3075 Anaerobic glycerol-3-phosphate dehydrogenase K00112 - 1.1.5.3 0.0000009825 61.0
TLS2_k127_3648206_101 ribonuclease activity - - - 0.000001247 56.0
TLS2_k127_3648206_102 Plasmid maintenance system killer K07334 - - 0.00000133 54.0
TLS2_k127_3648206_103 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00001542 54.0
TLS2_k127_3648206_104 Putative addiction module component - - - 0.00001703 56.0
TLS2_k127_3648206_105 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00002869 48.0
TLS2_k127_3648206_106 exo-alpha-(2->6)-sialidase activity - - - 0.00003746 53.0
TLS2_k127_3648206_108 TonB dependent receptor K02014 - - 0.0001715 53.0
TLS2_k127_3648206_109 DJ-1/PfpI family - - - 0.0003098 51.0
TLS2_k127_3648206_11 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 526.0
TLS2_k127_3648206_110 AAA domain - - - 0.0005528 49.0
TLS2_k127_3648206_111 NHL repeat - - - 0.0006616 52.0
TLS2_k127_3648206_112 - - - - 0.0008313 49.0
TLS2_k127_3648206_12 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 457.0
TLS2_k127_3648206_13 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 450.0
TLS2_k127_3648206_14 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 462.0
TLS2_k127_3648206_15 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 436.0
TLS2_k127_3648206_16 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 428.0
TLS2_k127_3648206_17 membrane organization - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 442.0
TLS2_k127_3648206_18 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 413.0
TLS2_k127_3648206_19 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 413.0
TLS2_k127_3648206_2 MacB-like periplasmic core domain - - - 3.045e-243 782.0
TLS2_k127_3648206_20 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 410.0
TLS2_k127_3648206_21 Histone deacetylase domain K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005853 385.0
TLS2_k127_3648206_22 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 355.0
TLS2_k127_3648206_23 protein histidine kinase activity K03407,K07678 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008965 320.0
TLS2_k127_3648206_24 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 321.0
TLS2_k127_3648206_25 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 316.0
TLS2_k127_3648206_26 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 314.0
TLS2_k127_3648206_27 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 307.0
TLS2_k127_3648206_28 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 291.0
TLS2_k127_3648206_29 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001038 289.0
TLS2_k127_3648206_3 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 2.614e-237 747.0
TLS2_k127_3648206_30 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004187 287.0
TLS2_k127_3648206_31 cAMP biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005577 295.0
TLS2_k127_3648206_32 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000004281 277.0
TLS2_k127_3648206_33 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001881 269.0
TLS2_k127_3648206_34 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000153 265.0
TLS2_k127_3648206_35 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001881 258.0
TLS2_k127_3648206_36 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007471 258.0
TLS2_k127_3648206_37 metallophosphoesterase K07096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002578 256.0
TLS2_k127_3648206_38 Reversible hydration of carbon dioxide K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000746 248.0
TLS2_k127_3648206_39 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000004125 242.0
TLS2_k127_3648206_4 Fumarase C C-terminus K01744 - 4.3.1.1 2.484e-210 675.0
TLS2_k127_3648206_40 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000007982 243.0
TLS2_k127_3648206_41 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.00000000000000000000000000000000000000000000000000000000000000005574 226.0
TLS2_k127_3648206_42 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.000000000000000000000000000000000000000000000000000000000000005668 235.0
TLS2_k127_3648206_43 COGs COG1845 Heme copper-type cytochrome quinol oxidase subunit 3 K02276,K02299 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000003249 220.0
TLS2_k127_3648206_44 HD domain K07023 - - 0.0000000000000000000000000000000000000000000000000000000000001337 229.0
TLS2_k127_3648206_45 PFAM GCN5-related N-acetyltransferase K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000000001139 207.0
TLS2_k127_3648206_46 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000004983 225.0
TLS2_k127_3648206_47 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000002837 207.0
TLS2_k127_3648206_48 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000001168 200.0
TLS2_k127_3648206_49 Integrase core domain - - - 0.00000000000000000000000000000000000000000000000000000239 196.0
TLS2_k127_3648206_5 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667 - 4.1.99.1 4.317e-206 650.0
TLS2_k127_3648206_50 - - - - 0.0000000000000000000000000000000000000000000000000000166 202.0
TLS2_k127_3648206_51 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000008196 190.0
TLS2_k127_3648206_52 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000887 194.0
TLS2_k127_3648206_53 peptidyl-prolyl cis-trans isomerase - - - 0.00000000000000000000000000000000000000000000000005928 182.0
TLS2_k127_3648206_54 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000000002004 182.0
TLS2_k127_3648206_55 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01476,K01480 - 3.5.3.1,3.5.3.11 0.00000000000000000000000000000000000000000000005633 185.0
TLS2_k127_3648206_56 UPF0316 protein - - - 0.0000000000000000000000000000000000000000000004917 175.0
TLS2_k127_3648206_57 PA domain - - - 0.0000000000000000000000000000000000000000000008767 184.0
TLS2_k127_3648206_58 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000003115 179.0
TLS2_k127_3648206_59 Cbs domain K04767 - - 0.000000000000000000000000000000000000000000009668 172.0
TLS2_k127_3648206_6 POT family K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 615.0
TLS2_k127_3648206_60 Belongs to the UPF0178 family K09768 - - 0.00000000000000000000000000000000000000000002075 175.0
TLS2_k127_3648206_61 FR47-like protein K06976 - - 0.0000000000000000000000000000000000000000312 162.0
TLS2_k127_3648206_62 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000002032 159.0
TLS2_k127_3648206_63 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000003407 165.0
TLS2_k127_3648206_64 DbpA RNA binding domain K05592 - 3.6.4.13 0.00000000000000000000000000000000000002741 163.0
TLS2_k127_3648206_65 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000009554 142.0
TLS2_k127_3648206_66 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.00000000000000000000000000000000001341 148.0
TLS2_k127_3648206_67 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000007967 136.0
TLS2_k127_3648206_68 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000001367 136.0
TLS2_k127_3648206_69 pilus organization - - - 0.000000000000000000000000000000001515 145.0
TLS2_k127_3648206_7 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 606.0
TLS2_k127_3648206_70 - - - - 0.00000000000000000000000000000008522 133.0
TLS2_k127_3648206_71 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000001615 129.0
TLS2_k127_3648206_72 Transglycosylase SLT domain - - - 0.0000000000000000000000000000008688 131.0
TLS2_k127_3648206_73 YoeB-like toxin of bacterial type II toxin-antitoxin system K19158 - - 0.00000000000000000000000000004642 119.0
TLS2_k127_3648206_74 PIN domain K07063 - - 0.000000000000000000000000006572 117.0
TLS2_k127_3648206_75 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000006704 109.0
TLS2_k127_3648206_76 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000008083 112.0
TLS2_k127_3648206_77 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000157 113.0
TLS2_k127_3648206_78 DSBA-like thioredoxin domain - - - 0.000000000000000000000001562 111.0
TLS2_k127_3648206_79 Membrane - - - 0.000000000000000000000007813 112.0
TLS2_k127_3648206_8 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 542.0
TLS2_k127_3648206_80 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.0000000000000000000002508 97.0
TLS2_k127_3648206_81 - - - - 0.000000000000000000002069 106.0
TLS2_k127_3648206_82 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000002128 96.0
TLS2_k127_3648206_83 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000000005029 92.0
TLS2_k127_3648206_84 Membrane - - - 0.00000000000000012 85.0
TLS2_k127_3648206_85 Plasmid stabilization system - - - 0.0000000000000003441 82.0
TLS2_k127_3648206_86 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.000000000000001496 78.0
TLS2_k127_3648206_87 NmrA family - - - 0.000000000000004324 80.0
TLS2_k127_3648206_88 toxin-antitoxin pair type II binding K08591,K19159 - 2.3.1.15 0.0000000000000166 78.0
TLS2_k127_3648206_89 Heavy-metal-associated domain K07213 - - 0.00000000000001749 75.0
TLS2_k127_3648206_9 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 550.0
TLS2_k127_3648206_90 Protein of unknown function (DUF1207) - - - 0.00000000000002785 87.0
TLS2_k127_3648206_91 MacB-like periplasmic core domain - - - 0.000000000000394 79.0
TLS2_k127_3648206_92 Transposase, Mutator family - - - 0.000000000003676 71.0
TLS2_k127_3648206_93 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000002011 68.0
TLS2_k127_3648206_94 4Fe-4S dicluster domain K00125,K03646 - 1.17.1.9 0.0000000001647 70.0
TLS2_k127_3648206_95 MULE transposase domain K07493 - - 0.000000001106 61.0
TLS2_k127_3648206_96 Integrase core domain - - - 0.000000001629 67.0
TLS2_k127_3648206_97 Methyltransferase domain - - - 0.000000007954 67.0
TLS2_k127_3648206_98 Yip1 domain - - - 0.00000001773 64.0
TLS2_k127_3648206_99 Putative addiction module component - - - 0.0000003333 59.0
TLS2_k127_3826596_0 efflux transmembrane transporter activity - - - 4.789e-217 692.0
TLS2_k127_3826596_1 TonB-dependent Receptor Plug Domain K02014 - - 5.7e-216 693.0
TLS2_k127_3826596_10 PFAM Adenosine AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 405.0
TLS2_k127_3826596_11 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007439 310.0
TLS2_k127_3826596_12 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 309.0
TLS2_k127_3826596_13 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 295.0
TLS2_k127_3826596_14 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001401 252.0
TLS2_k127_3826596_15 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000001751 228.0
TLS2_k127_3826596_16 Protein of unknown function, DUF393 - - - 0.00000000000000000000000000000000000000000006128 166.0
TLS2_k127_3826596_17 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000000000000000000000004802 159.0
TLS2_k127_3826596_18 Beta-lactamase K01286 - 3.4.16.4 0.000000000000000000000000000000000000000012 168.0
TLS2_k127_3826596_19 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000000001582 160.0
TLS2_k127_3826596_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 569.0
TLS2_k127_3826596_20 Histidine kinase - - - 0.000000000000000000000000000000000001339 159.0
TLS2_k127_3826596_21 nucleic acid-binding protein contains PIN domain - - - 0.00000000000000000000000000000000000216 141.0
TLS2_k127_3826596_22 Virulence activator alpha C-term - - - 0.0000000000000000000000000000000000165 146.0
TLS2_k127_3826596_23 anaerobic respiration K02568 - - 0.0000000000000000000000000000006686 134.0
TLS2_k127_3826596_24 protein kinase activity - - - 0.00000000000000000000000000001648 127.0
TLS2_k127_3826596_25 negative regulation of transcription, DNA-templated K10947 - - 0.0000000000000000000000000002476 117.0
TLS2_k127_3826596_26 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000006371 130.0
TLS2_k127_3826596_27 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.000000000000000000000000001083 114.0
TLS2_k127_3826596_28 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000001541 128.0
TLS2_k127_3826596_29 Beta-lactamase K17382 - - 0.0000000000000000000000003912 121.0
TLS2_k127_3826596_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 561.0
TLS2_k127_3826596_30 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000001823 112.0
TLS2_k127_3826596_31 Bacterial antitoxin of type II TA system, VapB - - - 0.00000000000000000002236 92.0
TLS2_k127_3826596_33 Pkd domain containing protein - - - 0.000000000000002144 91.0
TLS2_k127_3826596_34 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000003966 82.0
TLS2_k127_3826596_36 NapC/NirT cytochrome c family, N-terminal region - - - 0.0009656 49.0
TLS2_k127_3826596_4 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 505.0
TLS2_k127_3826596_5 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 467.0
TLS2_k127_3826596_6 N-4 methylation of cytosine K00571,K03497 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006829 441.0
TLS2_k127_3826596_7 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 408.0
TLS2_k127_3826596_8 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008477 434.0
TLS2_k127_3826596_9 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 407.0
TLS2_k127_3908322_0 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 463.0
TLS2_k127_3908322_1 AAA domain, putative AbiEii toxin, Type IV TA system K16907 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0015893,GO:0022857,GO:0042221,GO:0042493,GO:0042891,GO:0050896,GO:0051179,GO:0051234,GO:0055085 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008062 347.0
TLS2_k127_3908322_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000006242 121.0
TLS2_k127_3908322_12 CopC domain K07156 - - 0.0000000000008816 81.0
TLS2_k127_3908322_13 negative regulation of transcription, DNA-templated - - - 0.0000000002147 65.0
TLS2_k127_3908322_14 Bacterial regulatory proteins, tetR family - - - 0.0000000002758 63.0
TLS2_k127_3908322_15 acetyltransferase - - - 0.0000005966 59.0
TLS2_k127_3908322_16 NHL repeat - - - 0.000001085 60.0
TLS2_k127_3908322_2 Regulator of chromosome condensation (RCC1) repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000329 301.0
TLS2_k127_3908322_3 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000018 251.0
TLS2_k127_3908322_4 ATPase, P-type transporting, HAD superfamily, subfamily IC K16905 - - 0.000000000000000000000000000000000000000000001784 173.0
TLS2_k127_3908322_5 metallopeptidase activity K20276 - - 0.000000000000000000000000000000000000000000002833 189.0
TLS2_k127_3908322_6 transmembrane transport K01992,K16906 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 0.000000000000000000000000000000000000001142 158.0
TLS2_k127_3908322_7 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000002463 137.0
TLS2_k127_3908322_8 copper resistance K07245,K14166 - - 0.0000000000000000000000000002936 130.0
TLS2_k127_3908322_9 2 iron, 2 sulfur cluster binding K13643 - - 0.0000000000000000000000000004691 119.0
TLS2_k127_3973240_0 Copper amine oxidase, N2 domain K00276 - 1.4.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 552.0
TLS2_k127_3973240_1 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 474.0
TLS2_k127_3973240_10 Homeodomain-like domain K07497 - - 0.0000000000000000000000000000000000000000000000000004954 196.0
TLS2_k127_3973240_11 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000001912 193.0
TLS2_k127_3973240_12 ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - 0.0000000000000000000000000000101 133.0
TLS2_k127_3973240_13 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000002222 114.0
TLS2_k127_3973240_14 transposition K07497 - - 0.000000000000000000000004073 108.0
TLS2_k127_3973240_15 Polysaccharide biosynthesis protein - - - 0.0000000246 66.0
TLS2_k127_3973240_16 transcriptional regulator - - - 0.0000001726 63.0
TLS2_k127_3973240_2 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 439.0
TLS2_k127_3973240_3 slime layer polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 350.0
TLS2_k127_3973240_4 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 294.0
TLS2_k127_3973240_5 COGs COG2148 Sugar transferase involved in lipopolysaccharide synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003638 287.0
TLS2_k127_3973240_6 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009239 280.0
TLS2_k127_3973240_7 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000243 237.0
TLS2_k127_3973240_8 - - - - 0.0000000000000000000000000000000000000000000000000000000008631 211.0
TLS2_k127_3973240_9 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000003339 209.0
TLS2_k127_3973339_0 Prolyl oligopeptidase K01322 - 3.4.21.26 2.009e-232 739.0
TLS2_k127_3973339_1 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007796 596.0
TLS2_k127_3973339_2 Transglycosylase K21464 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005747 469.0
TLS2_k127_3973339_3 Leishmanolysin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 321.0
TLS2_k127_3973339_4 Oxidoreductase molybdopterin binding domain K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000001462 250.0
TLS2_k127_4016975_0 Thymidine kinase K00857 - 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000001005 256.0
TLS2_k127_4016975_1 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000002511 183.0
TLS2_k127_4081193_0 Protein kinase domain K12132 - 2.7.11.1 3.009e-284 885.0
TLS2_k127_4081193_1 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 548.0
TLS2_k127_4081193_10 transcriptional regulator PadR family - - - 0.0000000000000000000000000000000000000829 146.0
TLS2_k127_4081193_11 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000000001064 141.0
TLS2_k127_4081193_12 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.0000000000000000000003241 101.0
TLS2_k127_4081193_13 SnoaL-like domain - - - 0.000000000000000000002817 98.0
TLS2_k127_4081193_14 - - - - 0.00000000000000261 87.0
TLS2_k127_4081193_15 Transcription factor K19687 - - 0.00000000000006993 79.0
TLS2_k127_4081193_16 SnoaL-like domain - - - 0.000000000005767 72.0
TLS2_k127_4081193_17 - - - - 0.00000000002526 64.0
TLS2_k127_4081193_18 peptidase activity - - - 0.0000002899 57.0
TLS2_k127_4081193_2 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 437.0
TLS2_k127_4081193_3 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 369.0
TLS2_k127_4081193_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002718 277.0
TLS2_k127_4081193_5 Putative adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000303 267.0
TLS2_k127_4081193_6 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002771 243.0
TLS2_k127_4081193_7 aminopeptidase N - - - 0.00000000000000000000000000000000000000000000000000006175 209.0
TLS2_k127_4081193_8 - - - - 0.0000000000000000000000000000000000000000000483 165.0
TLS2_k127_4081193_9 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000004941 159.0
TLS2_k127_4145094_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 1.488e-305 952.0
TLS2_k127_4145094_1 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 3.62e-282 891.0
TLS2_k127_4145094_10 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008782 468.0
TLS2_k127_4145094_11 Carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 457.0
TLS2_k127_4145094_12 Thiolase, C-terminal domain K00626,K07508 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 436.0
TLS2_k127_4145094_13 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 430.0
TLS2_k127_4145094_14 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 440.0
TLS2_k127_4145094_15 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 415.0
TLS2_k127_4145094_16 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 394.0
TLS2_k127_4145094_17 Saccharopine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 379.0
TLS2_k127_4145094_18 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 377.0
TLS2_k127_4145094_19 Dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 372.0
TLS2_k127_4145094_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.398e-255 802.0
TLS2_k127_4145094_20 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009982 368.0
TLS2_k127_4145094_21 Putative RNA methylase family UPF0020 K07444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 357.0
TLS2_k127_4145094_22 Ferredoxin--NADP reductase K21567 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 347.0
TLS2_k127_4145094_23 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 346.0
TLS2_k127_4145094_24 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 342.0
TLS2_k127_4145094_25 Protein of unknown function (DUF1207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 338.0
TLS2_k127_4145094_26 PFAM Band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 313.0
TLS2_k127_4145094_27 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006207 308.0
TLS2_k127_4145094_28 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000809 295.0
TLS2_k127_4145094_29 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002645 291.0
TLS2_k127_4145094_3 Insulinase (Peptidase family M16) K07263 - - 5.65e-226 728.0
TLS2_k127_4145094_30 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001932 276.0
TLS2_k127_4145094_31 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005191 268.0
TLS2_k127_4145094_32 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005463 269.0
TLS2_k127_4145094_33 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000001115 264.0
TLS2_k127_4145094_34 cAMP biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000133 260.0
TLS2_k127_4145094_35 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000257 244.0
TLS2_k127_4145094_36 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000146 236.0
TLS2_k127_4145094_37 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000001717 231.0
TLS2_k127_4145094_38 photosystem I assembly BtpA K06971 - - 0.000000000000000000000000000000000000000000000000000000000000000001903 237.0
TLS2_k127_4145094_39 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000002821 247.0
TLS2_k127_4145094_4 Dehydrogenase K00117 - 1.1.5.2 8.039e-201 645.0
TLS2_k127_4145094_40 Deoxycytidylate deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000002599 225.0
TLS2_k127_4145094_41 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000001483 208.0
TLS2_k127_4145094_42 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000007078 198.0
TLS2_k127_4145094_43 Ankyrin repeats (many copies) - - - 0.00000000000000000000000000000000000000000000000000001732 214.0
TLS2_k127_4145094_44 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000002058 191.0
TLS2_k127_4145094_45 CBS domain K03699 - - 0.0000000000000000000000000000000000000000000000000679 190.0
TLS2_k127_4145094_46 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000001863 188.0
TLS2_k127_4145094_47 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000001292 181.0
TLS2_k127_4145094_48 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000002803 189.0
TLS2_k127_4145094_49 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000003448 173.0
TLS2_k127_4145094_5 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K02887,K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 605.0
TLS2_k127_4145094_50 HEAT repeats - - - 0.0000000000000000000000000000000000000000000001476 178.0
TLS2_k127_4145094_51 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000007171 177.0
TLS2_k127_4145094_52 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000008399 164.0
TLS2_k127_4145094_53 NUDIX domain - - - 0.0000000000000000000000000000000000000000006685 168.0
TLS2_k127_4145094_54 - - - - 0.0000000000000000000000000000000000000000006843 169.0
TLS2_k127_4145094_55 MlaD protein K02067 - - 0.000000000000000000000000000000000000000004816 167.0
TLS2_k127_4145094_56 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000000009273 158.0
TLS2_k127_4145094_57 Phosphoribosyl transferase domain K07101 - - 0.0000000000000000000000000000000000000001166 163.0
TLS2_k127_4145094_58 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000004552 154.0
TLS2_k127_4145094_59 Dodecin K09165 - - 0.0000000000000000000000000005094 115.0
TLS2_k127_4145094_6 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 575.0
TLS2_k127_4145094_60 deoxyhypusine monooxygenase activity K05385 - - 0.00000000000000000000001373 117.0
TLS2_k127_4145094_61 alpha/beta hydrolase fold - - - 0.0000000000000000000002441 101.0
TLS2_k127_4145094_62 Putative adhesin - - - 0.0000000000000000000002842 108.0
TLS2_k127_4145094_63 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000001657 103.0
TLS2_k127_4145094_64 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000264 106.0
TLS2_k127_4145094_65 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000000000008821 96.0
TLS2_k127_4145094_66 Serine aminopeptidase, S33 - - - 0.0000000000000000006459 96.0
TLS2_k127_4145094_68 - - - - 0.00000000000000002195 93.0
TLS2_k127_4145094_69 - - - - 0.00000000000006282 83.0
TLS2_k127_4145094_7 Glycosyl hydrolase-like 10 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000704 512.0
TLS2_k127_4145094_70 - - - - 0.00000000000009316 81.0
TLS2_k127_4145094_71 Protein of unknown function (DUF721) - - - 0.0000000000001372 77.0
TLS2_k127_4145094_72 type II secretion system protein E K02652 - - 0.000000000001701 81.0
TLS2_k127_4145094_73 - - - - 0.00000000000235 76.0
TLS2_k127_4145094_74 Ankyrin repeat - - - 0.00000000002899 77.0
TLS2_k127_4145094_75 - - - - 0.00000000005068 69.0
TLS2_k127_4145094_76 SprT-like family - - - 0.0000000003042 71.0
TLS2_k127_4145094_77 - - - - 0.000000005426 65.0
TLS2_k127_4145094_78 - - - - 0.000000008146 65.0
TLS2_k127_4145094_79 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.00000005482 61.0
TLS2_k127_4145094_8 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 477.0
TLS2_k127_4145094_80 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000002256 63.0
TLS2_k127_4145094_81 - - - - 0.000002005 58.0
TLS2_k127_4145094_82 alcohol dehydrogenase - - - 0.00006152 53.0
TLS2_k127_4145094_83 Tetratricopeptide repeats - - - 0.00009191 54.0
TLS2_k127_4145094_9 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 478.0
TLS2_k127_4149328_0 Catalyzes the synthesis of activated sulfate K00860,K00955 GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234 2.7.1.25,2.7.7.4 3.296e-255 801.0
TLS2_k127_4149328_1 Flavin containing amine oxidoreductase - - - 8.969e-213 674.0
TLS2_k127_4149328_10 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 361.0
TLS2_k127_4149328_11 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 343.0
TLS2_k127_4149328_12 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 349.0
TLS2_k127_4149328_13 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 332.0
TLS2_k127_4149328_14 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 314.0
TLS2_k127_4149328_15 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 306.0
TLS2_k127_4149328_16 Glycosyl transferases group 1 K16703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 306.0
TLS2_k127_4149328_17 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003016 291.0
TLS2_k127_4149328_18 Glucose / Sorbosone dehydrogenase K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002896 295.0
TLS2_k127_4149328_19 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002188 286.0
TLS2_k127_4149328_2 Sodium:sulfate symporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 575.0
TLS2_k127_4149328_20 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008332 276.0
TLS2_k127_4149328_21 O-Antigen ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002584 285.0
TLS2_k127_4149328_22 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002526 276.0
TLS2_k127_4149328_23 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003665 286.0
TLS2_k127_4149328_24 Protein involved in cellulose biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006818 271.0
TLS2_k127_4149328_25 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001766 263.0
TLS2_k127_4149328_26 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002018 262.0
TLS2_k127_4149328_27 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001387 255.0
TLS2_k127_4149328_28 Sugar transferase, PEP-CTERM EpsH1 system associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002819 257.0
TLS2_k127_4149328_29 ATP-grasp - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004434 255.0
TLS2_k127_4149328_3 UDP binding domain K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007283 565.0
TLS2_k127_4149328_30 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002982 253.0
TLS2_k127_4149328_31 Polysaccharide pyruvyl transferase K16710 - - 0.000000000000000000000000000000000000000000000000000000000000000001951 243.0
TLS2_k127_4149328_32 Bacterial sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000008097 226.0
TLS2_k127_4149328_33 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000001272 224.0
TLS2_k127_4149328_34 Inositol monophosphatase family K01082 - 3.1.3.7 0.0000000000000000000000000000000000000000000000000000000003978 212.0
TLS2_k127_4149328_35 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000001674 211.0
TLS2_k127_4149328_36 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000211 212.0
TLS2_k127_4149328_37 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000005311 202.0
TLS2_k127_4149328_38 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000008891 198.0
TLS2_k127_4149328_39 Protein of unknown function (DUF3485) - - - 0.0000000000000000000000000000000000000000000002585 174.0
TLS2_k127_4149328_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 556.0
TLS2_k127_4149328_40 transferase activity, transferring glycosyl groups K07011,K13659 - 2.4.1.264 0.0000000000000000000000000000000000000002737 164.0
TLS2_k127_4149328_41 lysyltransferase activity - - - 0.0000000000000000000000000000000000000002934 162.0
TLS2_k127_4149328_42 Bacterial Ig-like domain 2 - - - 0.000000000000000000000000000000000001418 161.0
TLS2_k127_4149328_43 Methyltransferase domain - - - 0.000000000000000000000000000000001545 139.0
TLS2_k127_4149328_45 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000003478 141.0
TLS2_k127_4149328_46 Glycosyl transferases group 1 - - - 0.00000000000000000000000000002674 131.0
TLS2_k127_4149328_47 Glycosyltransferase like family 2 - - - 0.000000000000000000537 98.0
TLS2_k127_4149328_48 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.00000000000000005804 94.0
TLS2_k127_4149328_49 Low molecular weight phosphotyrosine protein phosphatase K01104 - 3.1.3.48 0.000000000000002688 91.0
TLS2_k127_4149328_5 Flavin containing amine oxidoreductase K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 509.0
TLS2_k127_4149328_50 Polysaccharide deacetylase - - - 0.000000000001705 78.0
TLS2_k127_4149328_51 Carboxypeptidase regulatory-like domain - - - 0.0000000001329 76.0
TLS2_k127_4149328_52 - - - - 0.0000000001601 75.0
TLS2_k127_4149328_53 Sulfotransferase family - - - 0.00000008425 63.0
TLS2_k127_4149328_54 Flavin containing amine oxidoreductase - - - 0.0000008627 58.0
TLS2_k127_4149328_55 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000008511 56.0
TLS2_k127_4149328_56 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000009572 59.0
TLS2_k127_4149328_57 VanZ like family - - - 0.00002481 56.0
TLS2_k127_4149328_58 - - - - 0.00004089 53.0
TLS2_k127_4149328_6 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005805 511.0
TLS2_k127_4149328_61 - - - - 0.0002345 49.0
TLS2_k127_4149328_62 alcohol dehydrogenase K17760 - 1.1.9.1 0.00073 44.0
TLS2_k127_4149328_7 TIGRFAM sulfate adenylyltransferase, small subunit K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 474.0
TLS2_k127_4149328_8 Chain length determinant protein K16554 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004688 495.0
TLS2_k127_4149328_9 ABC transporter K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 400.0
TLS2_k127_421065_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.812e-288 896.0
TLS2_k127_421065_1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 2.704e-256 805.0
TLS2_k127_421065_10 Protein of unknown function (DUF559) - - - 0.00000000000000000000000000000000000006089 154.0
TLS2_k127_421065_11 DoxX-like family K15977 - - 0.00000000000000000000000000000000001085 139.0
TLS2_k127_421065_12 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000001785 133.0
TLS2_k127_421065_13 Heat shock 70 kDa protein K04043 - - 0.000000008401 60.0
TLS2_k127_421065_14 Nucleotidyltransferase domain - - - 0.000000009997 66.0
TLS2_k127_421065_2 TonB dependent receptor - - - 2.125e-252 813.0
TLS2_k127_421065_3 C4-dicarboxylate anaerobic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009459 541.0
TLS2_k127_421065_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 478.0
TLS2_k127_421065_5 protein catabolic process K03420,K13525,K17681 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 415.0
TLS2_k127_421065_6 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 413.0
TLS2_k127_421065_7 SusD family K21572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 389.0
TLS2_k127_421065_8 Asparaginase, N-terminal K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000009122 253.0
TLS2_k127_421065_9 - - - - 0.0000000000000000000000000000000000000000004131 165.0
TLS2_k127_4445068_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1110.0
TLS2_k127_4445068_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.652e-263 831.0
TLS2_k127_4445068_10 protoporphyrinogen oxidase K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 362.0
TLS2_k127_4445068_11 Bacterial dnaA protein K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 362.0
TLS2_k127_4445068_12 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007678 347.0
TLS2_k127_4445068_13 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 344.0
TLS2_k127_4445068_14 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 342.0
TLS2_k127_4445068_15 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 314.0
TLS2_k127_4445068_16 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 299.0
TLS2_k127_4445068_17 PFAM metal-dependent phosphohydrolase HD sub domain K09163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 291.0
TLS2_k127_4445068_18 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002013 291.0
TLS2_k127_4445068_19 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K00950,K01633 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000296 274.0
TLS2_k127_4445068_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.177e-200 644.0
TLS2_k127_4445068_20 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000311 252.0
TLS2_k127_4445068_21 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000002879 244.0
TLS2_k127_4445068_22 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000008287 232.0
TLS2_k127_4445068_23 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000004214 226.0
TLS2_k127_4445068_24 cheY-homologous receiver domain K03413 - - 0.00000000000000000000000000000000000000000000000000000004549 198.0
TLS2_k127_4445068_25 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000002734 190.0
TLS2_k127_4445068_26 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000008273 195.0
TLS2_k127_4445068_27 CheC-like family K03410 - - 0.00000000000000000000000000000000000000000000000008315 186.0
TLS2_k127_4445068_28 TilS substrate binding domain K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000001025 195.0
TLS2_k127_4445068_29 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000001088 181.0
TLS2_k127_4445068_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 4.902e-200 661.0
TLS2_k127_4445068_30 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000001467 181.0
TLS2_k127_4445068_31 - - - - 0.000000000000000000000000000000000000003154 160.0
TLS2_k127_4445068_32 MotA/TolQ/ExbB proton channel family K03561 - - 0.0000000000000000000000000000000000001974 152.0
TLS2_k127_4445068_33 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000001973 144.0
TLS2_k127_4445068_34 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000007309 144.0
TLS2_k127_4445068_35 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.000000000000000000000000000005693 128.0
TLS2_k127_4445068_36 biopolymer transport protein K03559 - - 0.000000000000000002119 91.0
TLS2_k127_4445068_37 biopolymer transport protein K03559 - - 0.0000000000000009873 82.0
TLS2_k127_4445068_38 PFAM CheW domain protein K03408 - - 0.000000000001982 75.0
TLS2_k127_4445068_39 PFAM iron dependent repressor K03709 - - 0.000000000002521 75.0
TLS2_k127_4445068_4 PFAM Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 601.0
TLS2_k127_4445068_40 - - - - 0.000000001939 64.0
TLS2_k127_4445068_41 Roadblock/LC7 domain - - - 0.00000003535 63.0
TLS2_k127_4445068_42 Outer membrane efflux protein K12340 - - 0.00000004669 66.0
TLS2_k127_4445068_43 Zinc ion binding K11997,K12035 GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564 2.3.2.27 0.0000003883 62.0
TLS2_k127_4445068_44 Tetratricopeptide repeat - - - 0.000000507 63.0
TLS2_k127_4445068_45 PFAM DivIVA family protein K04074 - - 0.000002524 60.0
TLS2_k127_4445068_46 Roadblock LC7 family protein K07131 GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 - 0.000008218 53.0
TLS2_k127_4445068_47 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0001447 52.0
TLS2_k127_4445068_48 Tetratricopeptide repeat - - - 0.0002308 53.0
TLS2_k127_4445068_5 AcrB/AcrD/AcrF family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 525.0
TLS2_k127_4445068_6 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 436.0
TLS2_k127_4445068_7 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 392.0
TLS2_k127_4445068_8 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 374.0
TLS2_k127_4445068_9 P2 response regulator binding domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 376.0
TLS2_k127_4518097_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1199.0
TLS2_k127_4518097_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 514.0
TLS2_k127_4518097_10 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009655 318.0
TLS2_k127_4518097_11 Formyl transferase, C-terminal domain K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000004861 268.0
TLS2_k127_4518097_12 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000002783 244.0
TLS2_k127_4518097_13 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000194 163.0
TLS2_k127_4518097_14 ISXO2-like transposase domain - - - 0.000000000000000000000000000000000000000001515 169.0
TLS2_k127_4518097_15 lipid kinase activity - - - 0.00000000000000000000000000000000000000002655 164.0
TLS2_k127_4518097_16 Glutathione peroxidase - - - 0.00000000000000000000000000000000002346 141.0
TLS2_k127_4518097_17 pfkB family carbohydrate kinase K00941,K14153 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000001025 125.0
TLS2_k127_4518097_18 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.000000000000001885 81.0
TLS2_k127_4518097_19 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000004076 77.0
TLS2_k127_4518097_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 457.0
TLS2_k127_4518097_20 PFAM PASTA domain - - - 0.0000000001783 70.0
TLS2_k127_4518097_21 YbbR-like protein - GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - 0.000105 52.0
TLS2_k127_4518097_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 398.0
TLS2_k127_4518097_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 373.0
TLS2_k127_4518097_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 368.0
TLS2_k127_4518097_6 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009597 366.0
TLS2_k127_4518097_7 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 326.0
TLS2_k127_4518097_8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008159 323.0
TLS2_k127_4518097_9 Surface antigen K07277,K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 339.0
TLS2_k127_4662593_0 peptidase S9B dipeptidylpeptidase IV domain protein - - - 3.261e-305 951.0
TLS2_k127_4662593_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 455.0
TLS2_k127_4662593_2 Transcriptional regulator K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000016 260.0
TLS2_k127_4662593_3 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000005491 217.0
TLS2_k127_4662593_4 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000001463 159.0
TLS2_k127_4662593_5 NmrA-like family - - - 0.00000000000000004836 85.0
TLS2_k127_4662593_6 23S rRNA-intervening sequence protein - - - 0.000000000007055 71.0
TLS2_k127_4662593_7 - - - - 0.0000003049 59.0
TLS2_k127_4662593_8 Acetyltransferase (GNAT) domain - - - 0.000006558 49.0
TLS2_k127_4684276_0 diguanylate cyclase - - - 0.0000000000000000000000000000000005997 141.0
TLS2_k127_4684276_1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 0.00000000000000000000000000002601 125.0
TLS2_k127_4736618_0 Glycosyl hydrolase family 65 central catalytic domain protein K00691,K05342 - 2.4.1.64,2.4.1.8 3.206e-304 952.0
TLS2_k127_4736618_1 Belongs to the UbiD family K03182 - 4.1.1.98 3.236e-304 941.0
TLS2_k127_4736618_10 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 589.0
TLS2_k127_4736618_11 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 490.0
TLS2_k127_4736618_12 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 487.0
TLS2_k127_4736618_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008063 447.0
TLS2_k127_4736618_14 Mechanosensitive ion channel K05802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 427.0
TLS2_k127_4736618_15 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 382.0
TLS2_k127_4736618_16 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 360.0
TLS2_k127_4736618_17 tryptophan 2,3-dioxygenase activity K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007953 340.0
TLS2_k127_4736618_18 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 346.0
TLS2_k127_4736618_19 Belongs to the arginase family K01476 - 3.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 338.0
TLS2_k127_4736618_2 Peptidase family M3 K01284 - 3.4.15.5 6.95e-293 914.0
TLS2_k127_4736618_20 Multicopper oxidase K08100 - 1.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 341.0
TLS2_k127_4736618_21 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K00575,K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 343.0
TLS2_k127_4736618_22 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 325.0
TLS2_k127_4736618_23 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 317.0
TLS2_k127_4736618_24 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 296.0
TLS2_k127_4736618_25 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 293.0
TLS2_k127_4736618_26 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005196 260.0
TLS2_k127_4736618_27 PFAM Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000002771 238.0
TLS2_k127_4736618_28 Cytochrome c K00376,K02305,K17760 - 1.1.9.1,1.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000552 228.0
TLS2_k127_4736618_29 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000002938 241.0
TLS2_k127_4736618_3 Zinc carboxypeptidase - - - 1.179e-272 865.0
TLS2_k127_4736618_30 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000007799 223.0
TLS2_k127_4736618_31 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000279 219.0
TLS2_k127_4736618_32 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000000000000000000000000000000005922 221.0
TLS2_k127_4736618_33 serine threonine protein kinase K00870 - 2.7.1.37 0.000000000000000000000000000000000000000000000000000000001363 217.0
TLS2_k127_4736618_34 - - - - 0.00000000000000000000000000000000000000000000000000000001815 203.0
TLS2_k127_4736618_35 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000000000000000000000000000000000000004843 186.0
TLS2_k127_4736618_36 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000008109 170.0
TLS2_k127_4736618_37 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000004907 160.0
TLS2_k127_4736618_38 PFAM secretion protein HlyD family protein - - - 0.000000000000000000000000000000000000001523 159.0
TLS2_k127_4736618_39 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000001931 156.0
TLS2_k127_4736618_4 Prolyl oligopeptidase family - - - 5.678e-246 791.0
TLS2_k127_4736618_40 PFAM Fibronectin type III domain - - - 0.0000000000000000000000000000000000007402 162.0
TLS2_k127_4736618_41 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000003236 138.0
TLS2_k127_4736618_42 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000004854 138.0
TLS2_k127_4736618_43 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000657 141.0
TLS2_k127_4736618_44 COG2346, Truncated hemoglobins K03406,K06886 GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057 - 0.0000000000000000000000000000006304 129.0
TLS2_k127_4736618_45 Cold shock protein domain K03704 - - 0.000000000000000000000000000001357 123.0
TLS2_k127_4736618_46 Forkhead associated domain - - - 0.000000000000000000000000000001786 133.0
TLS2_k127_4736618_47 Belongs to the peptidase S1B family - - - 0.00000000000000000000000000002534 132.0
TLS2_k127_4736618_48 nuclear chromosome segregation - - - 0.00000000000000000000000000002684 130.0
TLS2_k127_4736618_49 Sterol carrier protein domain - - - 0.0000000000000000000000000002702 128.0
TLS2_k127_4736618_5 protein import - - - 7.882e-236 755.0
TLS2_k127_4736618_50 pilus organization K12132 - 2.7.11.1 0.00000000000000000000000001583 119.0
TLS2_k127_4736618_51 Membrane-bound lysozyme-inhibitor of c-type lysozyme - - - 0.00000000000000000000002195 108.0
TLS2_k127_4736618_52 domain, Protein - - - 0.00000000000000000000004725 117.0
TLS2_k127_4736618_53 - - - - 0.00000000000000001 93.0
TLS2_k127_4736618_55 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0000000000002137 77.0
TLS2_k127_4736618_56 response regulator, receiver K01768,K11527,K19617 - 2.7.13.3,4.6.1.1 0.0000000000004146 77.0
TLS2_k127_4736618_58 usher protein - - - 0.000000009131 69.0
TLS2_k127_4736618_6 repeat protein - - - 9.246e-225 711.0
TLS2_k127_4736618_61 TonB-dependent receptor - - - 0.0001124 55.0
TLS2_k127_4736618_7 COG0457 FOG TPR repeat - - - 8.626e-208 661.0
TLS2_k127_4736618_8 ABC transporter, ATP-binding protein - - - 3.002e-200 649.0
TLS2_k127_4736618_9 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 596.0
TLS2_k127_4751600_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.311e-284 885.0
TLS2_k127_4751600_1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 594.0
TLS2_k127_4751600_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 584.0
TLS2_k127_4751600_3 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004547 511.0
TLS2_k127_4751600_4 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000000001741 158.0
TLS2_k127_4751600_5 Methylates ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000001443 144.0
TLS2_k127_4751600_6 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000007089 136.0
TLS2_k127_4767905_0 MacB-like periplasmic core domain - - - 6.313e-311 972.0
TLS2_k127_4767905_1 efflux transmembrane transporter activity - - - 1.059e-300 955.0
TLS2_k127_4767905_10 CobW/HypB/UreG, nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 508.0
TLS2_k127_4767905_100 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000005627 102.0
TLS2_k127_4767905_101 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000000000001213 102.0
TLS2_k127_4767905_102 Protein conserved in bacteria K01446 - - 0.0000000000000000000002067 100.0
TLS2_k127_4767905_103 Domain of unknown function (DUF4383) - - - 0.0000000000000000000008328 100.0
TLS2_k127_4767905_104 - - - - 0.0000000000000000000009085 107.0
TLS2_k127_4767905_105 - - - - 0.000000000000000000003499 105.0
TLS2_k127_4767905_106 Transcriptional regulator PadR-like family - - - 0.000000000000000000004393 96.0
TLS2_k127_4767905_107 phosphorelay signal transduction system K12132 - 2.7.11.1 0.00000000000000000005216 106.0
TLS2_k127_4767905_108 PFAM Hemerythrin HHE cation binding domain protein - - - 0.0000000000000000001678 102.0
TLS2_k127_4767905_109 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.0000000000000000006753 99.0
TLS2_k127_4767905_11 Regulator of chromosome condensation (RCC1) repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009036 527.0
TLS2_k127_4767905_110 - - - - 0.000000000000000004907 84.0
TLS2_k127_4767905_112 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000001971 98.0
TLS2_k127_4767905_113 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000004192 91.0
TLS2_k127_4767905_114 Transcriptional regulator K07729 - - 0.0000000000000004267 82.0
TLS2_k127_4767905_115 4Fe-4S single cluster domain of Ferredoxin I - - - 0.000000000001875 70.0
TLS2_k127_4767905_116 Helix-turn-helix XRE-family like proteins K07729 - - 0.000000000002359 74.0
TLS2_k127_4767905_117 - - - - 0.000000000005857 70.0
TLS2_k127_4767905_118 FtsX-like permease family - - - 0.000000000009105 68.0
TLS2_k127_4767905_12 Aldehyde dehydrogenase family K02618,K15514 - 1.2.1.77,1.2.1.91,3.3.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 485.0
TLS2_k127_4767905_120 peptidyl-tyrosine sulfation K13992 - - 0.00000000005694 68.0
TLS2_k127_4767905_121 - - - - 0.00000000007862 68.0
TLS2_k127_4767905_122 - - - - 0.00000000009358 66.0
TLS2_k127_4767905_123 PFAM Methyltransferase type 11 - - - 0.000000001205 67.0
TLS2_k127_4767905_124 BetI-type transcriptional repressor, C-terminal - - - 0.00000000158 66.0
TLS2_k127_4767905_125 Bacterial Ig-like domain 2 - - - 0.000000004719 70.0
TLS2_k127_4767905_126 Alpha beta hydrolase - - - 0.00000001122 66.0
TLS2_k127_4767905_127 Uncharacterized protein conserved in bacteria (DUF2200) - - - 0.00000001832 56.0
TLS2_k127_4767905_128 Hydrolases of the alpha beta superfamily K06889 - - 0.00000002067 60.0
TLS2_k127_4767905_13 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 488.0
TLS2_k127_4767905_130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000002343 58.0
TLS2_k127_4767905_131 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000008723 59.0
TLS2_k127_4767905_132 amine dehydrogenase activity - - - 0.000001078 60.0
TLS2_k127_4767905_133 Cytochrome c - - - 0.000001168 59.0
TLS2_k127_4767905_135 haloacid dehalogenase-like hydrolase - - - 0.000002322 53.0
TLS2_k127_4767905_136 Major facilitator superfamily - - - 0.000002605 59.0
TLS2_k127_4767905_14 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 456.0
TLS2_k127_4767905_140 - - - - 0.00001556 58.0
TLS2_k127_4767905_142 - - - - 0.00004554 52.0
TLS2_k127_4767905_143 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.00006785 48.0
TLS2_k127_4767905_144 Sodium:solute symporter family - - - 0.0001156 51.0
TLS2_k127_4767905_145 Involved in the tonB-independent uptake of proteins K03641 - - 0.0001259 56.0
TLS2_k127_4767905_147 alpha beta K06889 - - 0.0006926 49.0
TLS2_k127_4767905_148 domain, Protein K01179,K07260,K13735 - 3.2.1.4,3.4.17.14 0.0007882 52.0
TLS2_k127_4767905_15 S-(hydroxymethyl)glutathione dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009225 417.0
TLS2_k127_4767905_16 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 419.0
TLS2_k127_4767905_17 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 439.0
TLS2_k127_4767905_18 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 425.0
TLS2_k127_4767905_19 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006751 418.0
TLS2_k127_4767905_2 lysine biosynthetic process via aminoadipic acid - - - 9.261e-266 844.0
TLS2_k127_4767905_20 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 398.0
TLS2_k127_4767905_21 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007805 375.0
TLS2_k127_4767905_22 Peptidase family M20/M25/M40 K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 366.0
TLS2_k127_4767905_23 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 353.0
TLS2_k127_4767905_24 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006375 351.0
TLS2_k127_4767905_25 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 347.0
TLS2_k127_4767905_26 Multicopper oxidase K04753,K08100 - 1.3.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 352.0
TLS2_k127_4767905_27 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 334.0
TLS2_k127_4767905_28 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 336.0
TLS2_k127_4767905_29 Proto-chlorophyllide reductase 57 kD subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 327.0
TLS2_k127_4767905_3 Two component regulator propeller - - - 2.971e-240 794.0
TLS2_k127_4767905_30 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 331.0
TLS2_k127_4767905_31 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 312.0
TLS2_k127_4767905_32 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 320.0
TLS2_k127_4767905_33 phosphorelay sensor kinase activity K07711,K14980,K18143 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 321.0
TLS2_k127_4767905_34 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 304.0
TLS2_k127_4767905_35 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006399 321.0
TLS2_k127_4767905_36 NmrA-like family K19267 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 299.0
TLS2_k127_4767905_37 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K22110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 300.0
TLS2_k127_4767905_38 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000147 271.0
TLS2_k127_4767905_39 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002519 301.0
TLS2_k127_4767905_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 1.555e-227 743.0
TLS2_k127_4767905_40 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002816 272.0
TLS2_k127_4767905_41 amino acid transport K03406,K07242 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000696 276.0
TLS2_k127_4767905_42 peroxidase activity K00435 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001292 268.0
TLS2_k127_4767905_43 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001502 268.0
TLS2_k127_4767905_44 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001796 260.0
TLS2_k127_4767905_45 Rubrerythrin K22405 - 1.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000006714 274.0
TLS2_k127_4767905_46 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002186 276.0
TLS2_k127_4767905_47 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000003004 245.0
TLS2_k127_4767905_48 Fe-S protein K07140 GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0050896,GO:0098754 - 0.000000000000000000000000000000000000000000000000000000000000000000004122 244.0
TLS2_k127_4767905_49 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000004898 241.0
TLS2_k127_4767905_5 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.576e-203 649.0
TLS2_k127_4767905_50 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067,K06192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000755 245.0
TLS2_k127_4767905_51 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000001723 243.0
TLS2_k127_4767905_52 translation initiation factor activity K06996 - - 0.000000000000000000000000000000000000000000000000000000000000000006521 238.0
TLS2_k127_4767905_53 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000005442 243.0
TLS2_k127_4767905_54 protein tyrosine kinase activity K03593 - - 0.000000000000000000000000000000000000000000000000000000000001137 222.0
TLS2_k127_4767905_55 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000000002452 230.0
TLS2_k127_4767905_56 Predicted Zn-dependent protease (DUF2268) - - - 0.00000000000000000000000000000000000000000000000000000000001432 217.0
TLS2_k127_4767905_57 Polysaccharide lyase family 4, domain II - - - 0.00000000000000000000000000000000000000000000000000000000001702 222.0
TLS2_k127_4767905_58 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000005161 212.0
TLS2_k127_4767905_59 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000003879 206.0
TLS2_k127_4767905_6 PFAM Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 611.0
TLS2_k127_4767905_60 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000008091 200.0
TLS2_k127_4767905_61 Protein kinase domain K00870 - 2.7.1.37 0.000000000000000000000000000000000000000000000000006591 198.0
TLS2_k127_4767905_62 - - - - 0.000000000000000000000000000000000000000000000000009145 192.0
TLS2_k127_4767905_63 Bacterial PH domain K08981 - - 0.0000000000000000000000000000000000000000000000004496 183.0
TLS2_k127_4767905_64 Bacterial PH domain - - - 0.00000000000000000000000000000000000000000000006472 179.0
TLS2_k127_4767905_65 - - - - 0.00000000000000000000000000000000000000000000367 177.0
TLS2_k127_4767905_66 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000000008727 176.0
TLS2_k127_4767905_67 MgtC family K07507 GO:0008150,GO:0009405,GO:0044419,GO:0051704 - 0.00000000000000000000000000000000000000000002136 166.0
TLS2_k127_4767905_69 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000006525 168.0
TLS2_k127_4767905_7 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 543.0
TLS2_k127_4767905_70 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000000001785 181.0
TLS2_k127_4767905_71 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000006321 159.0
TLS2_k127_4767905_72 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000015 175.0
TLS2_k127_4767905_73 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000002204 162.0
TLS2_k127_4767905_74 - - - - 0.000000000000000000000000000000000000000009613 164.0
TLS2_k127_4767905_75 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000000008595 152.0
TLS2_k127_4767905_76 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.000000000000000000000000000000000000001155 161.0
TLS2_k127_4767905_77 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000000000000001817 152.0
TLS2_k127_4767905_78 WHG domain - - - 0.00000000000000000000000000000000000007108 150.0
TLS2_k127_4767905_79 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000008352 145.0
TLS2_k127_4767905_8 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 535.0
TLS2_k127_4767905_80 - - - - 0.00000000000000000000000000000000000557 160.0
TLS2_k127_4767905_81 exo-alpha-(2->6)-sialidase activity K01186 - 3.2.1.18 0.00000000000000000000000000000000002752 151.0
TLS2_k127_4767905_82 DinB family - - - 0.0000000000000000000000000000000001443 143.0
TLS2_k127_4767905_83 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000001222 140.0
TLS2_k127_4767905_84 Histidine kinase - - - 0.0000000000000000000000000000001575 134.0
TLS2_k127_4767905_85 - - - - 0.0000000000000000000000000000002379 130.0
TLS2_k127_4767905_86 - - - - 0.000000000000000000000000000004047 125.0
TLS2_k127_4767905_87 - - - - 0.00000000000000000000000000004047 126.0
TLS2_k127_4767905_88 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000005343 123.0
TLS2_k127_4767905_89 Protein conserved in bacteria K09857 - - 0.00000000000000000000000000008409 128.0
TLS2_k127_4767905_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 542.0
TLS2_k127_4767905_90 - - - - 0.0000000000000000000000000001041 123.0
TLS2_k127_4767905_91 BAAT / Acyl-CoA thioester hydrolase C terminal K06889 - - 0.0000000000000000000000000002125 130.0
TLS2_k127_4767905_92 alpha/beta hydrolase fold - - - 0.000000000000000000000000001884 115.0
TLS2_k127_4767905_93 - - - - 0.00000000000000000000000001065 124.0
TLS2_k127_4767905_94 Serine aminopeptidase, S33 K06889 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - 0.00000000000000000000000001812 119.0
TLS2_k127_4767905_95 DinB superfamily - - - 0.00000000000000000000000002717 115.0
TLS2_k127_4767905_96 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000004965 117.0
TLS2_k127_4767905_97 Domain of unknown function (DUF4956) - - - 0.000000000000000000000001975 118.0
TLS2_k127_4767905_98 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000002372 114.0
TLS2_k127_4767905_99 Proto-chlorophyllide reductase 57 kd subunit - - - 0.000000000000000000000005633 107.0
TLS2_k127_4768687_0 Carbamoyltransferase C-terminus K00612 - - 6.56e-303 938.0
TLS2_k127_4768687_1 Dienelactone hydrolase family - - - 3.447e-274 862.0
TLS2_k127_4768687_10 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 418.0
TLS2_k127_4768687_11 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 368.0
TLS2_k127_4768687_12 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 352.0
TLS2_k127_4768687_13 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 345.0
TLS2_k127_4768687_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 340.0
TLS2_k127_4768687_15 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 308.0
TLS2_k127_4768687_16 beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 296.0
TLS2_k127_4768687_17 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003508 287.0
TLS2_k127_4768687_18 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000696 276.0
TLS2_k127_4768687_19 glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002044 265.0
TLS2_k127_4768687_2 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 593.0
TLS2_k127_4768687_20 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000256 251.0
TLS2_k127_4768687_21 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001635 246.0
TLS2_k127_4768687_22 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000004684 236.0
TLS2_k127_4768687_23 TM2 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000102 239.0
TLS2_k127_4768687_24 Glycosyltransferase family 87 - - - 0.0000000000000000000000000000000000000000000000000000000000000001396 238.0
TLS2_k127_4768687_25 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000004204 226.0
TLS2_k127_4768687_26 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000445 229.0
TLS2_k127_4768687_27 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000009853 227.0
TLS2_k127_4768687_28 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000008755 219.0
TLS2_k127_4768687_29 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000002049 214.0
TLS2_k127_4768687_3 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 558.0
TLS2_k127_4768687_30 mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000000000000000000000000002469 199.0
TLS2_k127_4768687_31 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000001379 196.0
TLS2_k127_4768687_32 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000006515 191.0
TLS2_k127_4768687_33 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000000000000000000005269 188.0
TLS2_k127_4768687_34 polysaccharide biosynthetic process - - - 0.000000000000000000000000000000000000000000004835 181.0
TLS2_k127_4768687_35 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000003661 174.0
TLS2_k127_4768687_36 Glycosyltransferase family 87 - - - 0.0000000000000000000000000000000000000000009976 173.0
TLS2_k127_4768687_37 NmrA-like family - - - 0.000000000000000000000000000000000000000001375 161.0
TLS2_k127_4768687_38 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000247 147.0
TLS2_k127_4768687_39 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000005194 150.0
TLS2_k127_4768687_4 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 526.0
TLS2_k127_4768687_40 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000006383 150.0
TLS2_k127_4768687_41 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000001226 154.0
TLS2_k127_4768687_42 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000003076 146.0
TLS2_k127_4768687_43 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000008691 137.0
TLS2_k127_4768687_44 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000003258 127.0
TLS2_k127_4768687_45 polysaccharide biosynthetic process - - - 0.000000000000000000000000000002006 138.0
TLS2_k127_4768687_46 - - - - 0.000000000000000000000000000009291 130.0
TLS2_k127_4768687_47 Methyltransferase domain - - - 0.0000000000000000000000000004506 124.0
TLS2_k127_4768687_48 - - - - 0.000000000000000000000000198 111.0
TLS2_k127_4768687_49 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000001509 105.0
TLS2_k127_4768687_5 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 535.0
TLS2_k127_4768687_50 Protein of unknown function (DUF3667) - - - 0.0000000000000000000007832 106.0
TLS2_k127_4768687_51 deoxyhypusine monooxygenase activity - - - 0.000000000000000000001362 107.0
TLS2_k127_4768687_52 lipolytic protein G-D-S-L family - - - 0.0000000000000002739 92.0
TLS2_k127_4768687_53 glycosyl transferase family - - - 0.000000000000001028 91.0
TLS2_k127_4768687_54 - - - - 0.000000000000004375 88.0
TLS2_k127_4768687_55 Adenylate cyclase - - - 0.000000000000006584 89.0
TLS2_k127_4768687_56 negative regulation of transcription, DNA-templated - - - 0.000000000000009681 82.0
TLS2_k127_4768687_57 - - - - 0.0000000000004097 76.0
TLS2_k127_4768687_58 - - - - 0.000000000001557 74.0
TLS2_k127_4768687_59 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000006149 75.0
TLS2_k127_4768687_6 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 530.0
TLS2_k127_4768687_60 Transcriptional regulator padr family - - - 0.0000000003317 69.0
TLS2_k127_4768687_61 Peptidase dimerisation domain - - - 0.000000003394 63.0
TLS2_k127_4768687_62 Bacterial membrane protein YfhO - - - 0.000000006883 69.0
TLS2_k127_4768687_63 MacB-like periplasmic core domain - - - 0.0000001465 53.0
TLS2_k127_4768687_64 DinB family - - - 0.000000285 60.0
TLS2_k127_4768687_65 membrane - - - 0.000001527 61.0
TLS2_k127_4768687_66 membrane K08972 - - 0.00001349 52.0
TLS2_k127_4768687_67 - - - - 0.00007683 53.0
TLS2_k127_4768687_7 PFAM FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 497.0
TLS2_k127_4768687_8 Aldolase K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006209 417.0
TLS2_k127_4768687_9 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 421.0
TLS2_k127_4801489_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1504.0
TLS2_k127_4801489_1 aconitate hydratase activity K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0 1197.0
TLS2_k127_4801489_10 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 574.0
TLS2_k127_4801489_100 NHL repeat - - - 0.00001347 57.0
TLS2_k127_4801489_102 Domain of unknown function (DU1801) - - - 0.00005384 51.0
TLS2_k127_4801489_103 - - - - 0.0001016 55.0
TLS2_k127_4801489_104 exodeoxyribonuclease I activity - - - 0.0001081 53.0
TLS2_k127_4801489_11 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 566.0
TLS2_k127_4801489_12 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 556.0
TLS2_k127_4801489_13 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 523.0
TLS2_k127_4801489_14 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 532.0
TLS2_k127_4801489_15 sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 484.0
TLS2_k127_4801489_16 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 463.0
TLS2_k127_4801489_17 Sodium:neurotransmitter symporter family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 469.0
TLS2_k127_4801489_18 Aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 466.0
TLS2_k127_4801489_19 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 459.0
TLS2_k127_4801489_2 Amidohydrolase family - - - 0.0 1171.0
TLS2_k127_4801489_20 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 450.0
TLS2_k127_4801489_21 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 456.0
TLS2_k127_4801489_22 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000495 451.0
TLS2_k127_4801489_23 Putative serine dehydratase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 427.0
TLS2_k127_4801489_24 PHP domain protein K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 437.0
TLS2_k127_4801489_25 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009053 411.0
TLS2_k127_4801489_26 cAMP biosynthetic process K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 419.0
TLS2_k127_4801489_27 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 404.0
TLS2_k127_4801489_28 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 397.0
TLS2_k127_4801489_29 Belongs to the D-alanine--D-alanine ligase family K01921 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 393.0
TLS2_k127_4801489_3 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 4.2e-285 905.0
TLS2_k127_4801489_30 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 400.0
TLS2_k127_4801489_31 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 362.0
TLS2_k127_4801489_32 Histidine Phosphotransfer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008144 351.0
TLS2_k127_4801489_33 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 334.0
TLS2_k127_4801489_34 Methyl-transferase K18911 - 2.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 317.0
TLS2_k127_4801489_35 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 303.0
TLS2_k127_4801489_36 Psort location Cytoplasmic, score K00008,K00060 - 1.1.1.103,1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 315.0
TLS2_k127_4801489_37 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 328.0
TLS2_k127_4801489_38 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007243 305.0
TLS2_k127_4801489_39 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 303.0
TLS2_k127_4801489_4 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 6.31e-281 891.0
TLS2_k127_4801489_40 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002577 295.0
TLS2_k127_4801489_41 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008728 270.0
TLS2_k127_4801489_42 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000239 264.0
TLS2_k127_4801489_43 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000001129 270.0
TLS2_k127_4801489_44 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001551 287.0
TLS2_k127_4801489_45 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002224 288.0
TLS2_k127_4801489_46 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003198 251.0
TLS2_k127_4801489_47 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000003552 233.0
TLS2_k127_4801489_48 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000004494 228.0
TLS2_k127_4801489_49 - - - - 0.000000000000000000000000000000000000000000000000000000000000005751 231.0
TLS2_k127_4801489_5 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 6.068e-247 784.0
TLS2_k127_4801489_50 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000001965 221.0
TLS2_k127_4801489_51 PFAM Metal-dependent phosphohydrolase, HD K06951 - - 0.000000000000000000000000000000000000000000000000000000000001152 220.0
TLS2_k127_4801489_52 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000005739 197.0
TLS2_k127_4801489_53 Bacterial transcription activator, effector binding domain K13652 - - 0.000000000000000000000000000000000000000000000001879 187.0
TLS2_k127_4801489_54 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000000003768 182.0
TLS2_k127_4801489_55 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000142 176.0
TLS2_k127_4801489_56 ECF sigma factor - - - 0.00000000000000000000000000000000000000002259 160.0
TLS2_k127_4801489_57 Peptidase family S41 - - - 0.00000000000000000000000000000000000000007723 168.0
TLS2_k127_4801489_58 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000005899 157.0
TLS2_k127_4801489_59 - - - - 0.000000000000000000000000000000000000002647 168.0
TLS2_k127_4801489_6 Elongation factor G, domain IV K02355 - - 2.779e-235 747.0
TLS2_k127_4801489_60 PFAM Rhomboid family protein - - - 0.00000000000000000000000000000000000002632 154.0
TLS2_k127_4801489_61 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000009313 153.0
TLS2_k127_4801489_62 Beta-lactamase - - - 0.0000000000000000000000000000000000005756 158.0
TLS2_k127_4801489_63 acr, cog1993 K09137 - - 0.0000000000000000000000000000000000694 145.0
TLS2_k127_4801489_64 - - - - 0.00000000000000000000000000000001454 135.0
TLS2_k127_4801489_65 alpha beta K06889 - - 0.00000000000000000000000000000002725 141.0
TLS2_k127_4801489_66 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000209 130.0
TLS2_k127_4801489_67 Dienelactone hydrolase family - - - 0.00000000000000000000000000001831 129.0
TLS2_k127_4801489_68 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000003529 127.0
TLS2_k127_4801489_69 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000007912 130.0
TLS2_k127_4801489_7 Amidohydrolase family - - - 1.364e-222 704.0
TLS2_k127_4801489_70 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000001944 121.0
TLS2_k127_4801489_71 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000007002 122.0
TLS2_k127_4801489_72 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000003221 116.0
TLS2_k127_4801489_73 Zincin-like metallopeptidase - - - 0.0000000000000000000000001401 115.0
TLS2_k127_4801489_75 CHASE - - - 0.000000000000000000000003256 107.0
TLS2_k127_4801489_76 - - - - 0.0000000000000000000001598 114.0
TLS2_k127_4801489_77 CrcB-like protein, Camphor Resistance (CrcB) K06199 - - 0.0000000000000000000001725 102.0
TLS2_k127_4801489_78 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000002625 104.0
TLS2_k127_4801489_79 peptide catabolic process - - - 0.0000000000000000000005592 112.0
TLS2_k127_4801489_8 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 619.0
TLS2_k127_4801489_80 Putative esterase - - - 0.000000000000000000003412 109.0
TLS2_k127_4801489_81 negative regulation of transcription, DNA-templated - - - 0.00000000000000000005493 93.0
TLS2_k127_4801489_83 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.000000000000000003987 94.0
TLS2_k127_4801489_84 negative regulation of transcription, DNA-templated - - - 0.00000000000000003537 89.0
TLS2_k127_4801489_85 transcriptional regulator PadR family - - - 0.0000000000000000883 85.0
TLS2_k127_4801489_86 - - - - 0.0000000000000001153 81.0
TLS2_k127_4801489_87 TIGRFAM MJ0042 family finger-like protein - - - 0.0000000000000001327 89.0
TLS2_k127_4801489_88 Bacterial regulatory proteins, tetR family - - - 0.0000000000000001733 88.0
TLS2_k127_4801489_89 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000002649 83.0
TLS2_k127_4801489_9 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 608.0
TLS2_k127_4801489_90 Gas vesicle synthesis protein GvpL/GvpF - - - 0.00000000000001031 82.0
TLS2_k127_4801489_91 - - - - 0.00000000000006689 79.0
TLS2_k127_4801489_92 Rieske-like [2Fe-2S] domain K05710,K18087 - - 0.000000000002735 73.0
TLS2_k127_4801489_93 amine dehydrogenase activity - - - 0.0000000004025 72.0
TLS2_k127_4801489_94 transcriptional regulators - - - 0.0000000005706 65.0
TLS2_k127_4801489_95 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000209 69.0
TLS2_k127_4801489_96 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000002005 59.0
TLS2_k127_4801489_97 Histidine kinase - - - 0.000001406 57.0
TLS2_k127_4801489_98 Trypsin K04771 - 3.4.21.107 0.000001744 59.0
TLS2_k127_4801489_99 amine dehydrogenase activity - - - 0.000008967 59.0
TLS2_k127_4958716_0 TonB-dependent receptor - - - 0.0 1309.0
TLS2_k127_4958716_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0 1109.0
TLS2_k127_4958716_10 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 524.0
TLS2_k127_4958716_11 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 488.0
TLS2_k127_4958716_12 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 486.0
TLS2_k127_4958716_13 RecQ zinc-binding K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007838 460.0
TLS2_k127_4958716_14 7TM receptor with intracellular HD hydrolase K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 466.0
TLS2_k127_4958716_15 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 450.0
TLS2_k127_4958716_16 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 430.0
TLS2_k127_4958716_17 PFAM NAD dependent epimerase dehydratase family K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009453 419.0
TLS2_k127_4958716_18 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 424.0
TLS2_k127_4958716_19 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 413.0
TLS2_k127_4958716_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 3.752e-297 935.0
TLS2_k127_4958716_20 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007745 381.0
TLS2_k127_4958716_21 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008668 379.0
TLS2_k127_4958716_22 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 373.0
TLS2_k127_4958716_23 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 372.0
TLS2_k127_4958716_24 Trypsin K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 371.0
TLS2_k127_4958716_25 ABC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008857 356.0
TLS2_k127_4958716_26 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 331.0
TLS2_k127_4958716_27 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 315.0
TLS2_k127_4958716_28 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007857 295.0
TLS2_k127_4958716_29 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 316.0
TLS2_k127_4958716_3 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 9.005e-235 739.0
TLS2_k127_4958716_30 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 289.0
TLS2_k127_4958716_31 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003281 282.0
TLS2_k127_4958716_32 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002858 286.0
TLS2_k127_4958716_33 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000948 270.0
TLS2_k127_4958716_34 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001023 275.0
TLS2_k127_4958716_35 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002338 281.0
TLS2_k127_4958716_36 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000005721 271.0
TLS2_k127_4958716_37 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000001049 259.0
TLS2_k127_4958716_38 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000003468 246.0
TLS2_k127_4958716_39 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000003458 236.0
TLS2_k127_4958716_4 Carboxyl transferase domain - - - 4.022e-233 734.0
TLS2_k127_4958716_40 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000001925 219.0
TLS2_k127_4958716_41 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000001733 205.0
TLS2_k127_4958716_42 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.00000000000000000000000000000000000000000000000000000000724 210.0
TLS2_k127_4958716_43 Belongs to the enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.000000000000000000000000000000000000000000000000000000241 203.0
TLS2_k127_4958716_44 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000003342 181.0
TLS2_k127_4958716_45 - - - - 0.000000000000000000000000000000000000000000001527 168.0
TLS2_k127_4958716_46 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000005144 152.0
TLS2_k127_4958716_47 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000001045 160.0
TLS2_k127_4958716_48 tRNA synthetases class II (D, K and N) K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.0000000000000000000000000000000000002706 141.0
TLS2_k127_4958716_49 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000000000002312 142.0
TLS2_k127_4958716_5 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 4.366e-231 756.0
TLS2_k127_4958716_50 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000008708 132.0
TLS2_k127_4958716_51 Domain of unknown function (DUF814) - - - 0.00000000000000000000000000000005946 143.0
TLS2_k127_4958716_52 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000004504 123.0
TLS2_k127_4958716_53 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.000000000000000000000000000006198 126.0
TLS2_k127_4958716_54 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000002057 120.0
TLS2_k127_4958716_55 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000014 115.0
TLS2_k127_4958716_56 - - - - 0.0000000000000000000005244 109.0
TLS2_k127_4958716_57 phosphorelay signal transduction system - - - 0.0000000000000000001889 92.0
TLS2_k127_4958716_58 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000001362 88.0
TLS2_k127_4958716_59 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000001811 95.0
TLS2_k127_4958716_6 Acyclic terpene utilisation family protein AtuA - - - 3.186e-198 627.0
TLS2_k127_4958716_61 PFAM VanZ like - - - 0.0000001373 60.0
TLS2_k127_4958716_62 LytR cell envelope-related transcriptional attenuator - - - 0.0000002358 59.0
TLS2_k127_4958716_63 amine dehydrogenase activity - - - 0.00003255 56.0
TLS2_k127_4958716_7 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009527 599.0
TLS2_k127_4958716_8 adenylosuccinate lyase K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 576.0
TLS2_k127_4958716_9 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 549.0
TLS2_k127_4997303_0 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341,K05559 - 1.6.5.3 2.757e-318 999.0
TLS2_k127_4997303_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 3.915e-253 801.0
TLS2_k127_4997303_10 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 445.0
TLS2_k127_4997303_11 Transposase, Mutator family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 429.0
TLS2_k127_4997303_12 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 421.0
TLS2_k127_4997303_13 Domain present in phytochromes and cGMP-specific phosphodiesterases. K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 407.0
TLS2_k127_4997303_14 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 389.0
TLS2_k127_4997303_15 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 374.0
TLS2_k127_4997303_16 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 362.0
TLS2_k127_4997303_17 M42 glutamyl aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 371.0
TLS2_k127_4997303_18 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 350.0
TLS2_k127_4997303_19 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 345.0
TLS2_k127_4997303_2 nuclear chromosome segregation - - - 3.175e-205 680.0
TLS2_k127_4997303_20 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 295.0
TLS2_k127_4997303_21 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002725 266.0
TLS2_k127_4997303_22 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002495 269.0
TLS2_k127_4997303_23 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001133 246.0
TLS2_k127_4997303_24 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000003062 232.0
TLS2_k127_4997303_25 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000000000000000002898 220.0
TLS2_k127_4997303_26 dolichyl monophosphate biosynthetic process K00981,K18678 GO:0003674,GO:0003824,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0006766,GO:0006775,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0010276,GO:0016101,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017144,GO:0018130,GO:0033306,GO:0034308,GO:0042360,GO:0042362,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1903173 2.7.1.182,2.7.7.41 0.00000000000000000000000000000000000000000000000000000000003183 213.0
TLS2_k127_4997303_27 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000000000000000000000000004558 218.0
TLS2_k127_4997303_28 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000005823 215.0
TLS2_k127_4997303_29 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000001177 212.0
TLS2_k127_4997303_3 Putative glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 618.0
TLS2_k127_4997303_30 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000351 203.0
TLS2_k127_4997303_31 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000000000007935 195.0
TLS2_k127_4997303_32 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000001212 180.0
TLS2_k127_4997303_33 Na+/H+ ion antiporter subunit K05562 - - 0.0000000000000000000000000000000000000000003584 163.0
TLS2_k127_4997303_34 YceI-like domain - - - 0.000000000000000000000000000000000000001063 156.0
TLS2_k127_4997303_35 PFAM Na H antiporter subunit K05564 - - 0.00000000000000000000000000000000003556 139.0
TLS2_k127_4997303_36 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000007217 141.0
TLS2_k127_4997303_37 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05560 - - 0.00000000000000000000000000000001273 136.0
TLS2_k127_4997303_38 Domain of unknown function (DUF5118) - - - 0.0000000000000000000000000003251 126.0
TLS2_k127_4997303_39 COG2212 Multisubunit Na H antiporter, MnhF subunit K05563 - - 0.0000000000000000000000000005844 116.0
TLS2_k127_4997303_4 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 597.0
TLS2_k127_4997303_40 Domain of unknown function (DUF5118) - - - 0.0000000000000000000000863 105.0
TLS2_k127_4997303_41 transposase activity K07493 - - 0.0000004229 57.0
TLS2_k127_4997303_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 544.0
TLS2_k127_4997303_6 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 509.0
TLS2_k127_4997303_7 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit K00342,K05561,K05568 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 509.0
TLS2_k127_4997303_8 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009168 494.0
TLS2_k127_4997303_9 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 471.0
TLS2_k127_5004189_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0 1095.0
TLS2_k127_5004189_1 ABC transporter K06020 - 3.6.3.25 9.221e-262 816.0
TLS2_k127_5004189_10 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 478.0
TLS2_k127_5004189_11 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 482.0
TLS2_k127_5004189_12 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 473.0
TLS2_k127_5004189_13 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 470.0
TLS2_k127_5004189_14 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 453.0
TLS2_k127_5004189_15 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007474 427.0
TLS2_k127_5004189_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005676 402.0
TLS2_k127_5004189_17 Dihydroxyacetone kinase family K07030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 365.0
TLS2_k127_5004189_18 Membrane dipeptidase (Peptidase family M19) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 382.0
TLS2_k127_5004189_19 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008377 351.0
TLS2_k127_5004189_2 Histidine kinase - - - 1.534e-260 837.0
TLS2_k127_5004189_20 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 334.0
TLS2_k127_5004189_21 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 351.0
TLS2_k127_5004189_22 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007423 329.0
TLS2_k127_5004189_23 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 318.0
TLS2_k127_5004189_24 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 316.0
TLS2_k127_5004189_25 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 324.0
TLS2_k127_5004189_26 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 301.0
TLS2_k127_5004189_27 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 289.0
TLS2_k127_5004189_28 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001646 286.0
TLS2_k127_5004189_29 ATPase activity K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000168 285.0
TLS2_k127_5004189_3 FAD dependent oxidoreductase - - - 9.703e-206 659.0
TLS2_k127_5004189_30 -acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001508 278.0
TLS2_k127_5004189_31 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006769 286.0
TLS2_k127_5004189_32 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003594 285.0
TLS2_k127_5004189_33 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000341 232.0
TLS2_k127_5004189_34 transmembrane transport K01992 - - 0.0000000000000000000000000000000000000000000000000000000000003089 227.0
TLS2_k127_5004189_35 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000001637 227.0
TLS2_k127_5004189_36 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000007183 222.0
TLS2_k127_5004189_37 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000004477 231.0
TLS2_k127_5004189_38 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000003548 228.0
TLS2_k127_5004189_39 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000007919 215.0
TLS2_k127_5004189_4 C4-dicarboxylate anaerobic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008498 565.0
TLS2_k127_5004189_40 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000002447 198.0
TLS2_k127_5004189_41 BlaR1 peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000003996 203.0
TLS2_k127_5004189_42 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000001072 206.0
TLS2_k127_5004189_43 PFAM methyltransferase - - - 0.000000000000000000000000000000000000000000000000002676 196.0
TLS2_k127_5004189_44 PFAM diacylglycerol kinase catalytic region - - - 0.000000000000000000000000000000000000000000000000009382 192.0
TLS2_k127_5004189_45 Response regulator, receiver K11443 - - 0.00000000000000000000000000000000000000000000000001346 182.0
TLS2_k127_5004189_46 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000008209 180.0
TLS2_k127_5004189_47 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000005013 184.0
TLS2_k127_5004189_48 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000000000006233 177.0
TLS2_k127_5004189_49 Glycosyltransferase family 87 - - - 0.00000000000000000000000000000000000000000000000122 192.0
TLS2_k127_5004189_5 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007066 552.0
TLS2_k127_5004189_50 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000006868 173.0
TLS2_k127_5004189_51 alpha-L-arabinofuranosidase - - - 0.000000000000000000000000000000000000000000001128 192.0
TLS2_k127_5004189_52 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000000000001533 172.0
TLS2_k127_5004189_53 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000448 164.0
TLS2_k127_5004189_54 xenon atom binding K09022 GO:0001505,GO:0001655,GO:0001822,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005504,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005759,GO:0005777,GO:0005829,GO:0006082,GO:0006139,GO:0006412,GO:0006417,GO:0006457,GO:0006518,GO:0006520,GO:0006544,GO:0006549,GO:0006566,GO:0006567,GO:0006725,GO:0006807,GO:0007049,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008150,GO:0008152,GO:0008285,GO:0008289,GO:0008652,GO:0009056,GO:0009058,GO:0009059,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009081,GO:0009082,GO:0009097,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016054,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0017144,GO:0017148,GO:0019222,GO:0019239,GO:0019518,GO:0019538,GO:0019752,GO:0022402,GO:0030323,GO:0030324,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032543,GO:0033293,GO:0033993,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0035295,GO:0036041,GO:0036094,GO:0042127,GO:0042133,GO:0042221,GO:0042579,GO:0042737,GO:0042802,GO:0042803,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048513,GO:0048519,GO:0048523,GO:0048731,GO:0048856,GO:0050678,GO:0050680,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0060322,GO:0060541,GO:0065007,GO:0065008,GO:0070013,GO:0070314,GO:0071704,GO:0072001,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140053,GO:0140098,GO:1901360,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1902074,GO:1904012,GO:1904013,GO:2000112,GO:2000113 3.5.99.10 0.000000000000000000000000000000000000000004854 158.0
TLS2_k127_5004189_55 Calcineurin-like phosphoesterase K03269 - 3.6.1.54 0.0000000000000000000000000000000000000001017 160.0
TLS2_k127_5004189_56 Penicillinase repressor - - - 0.000000000000000000000000000000000000001102 151.0
TLS2_k127_5004189_57 COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000001594 149.0
TLS2_k127_5004189_58 - - - - 0.00000000000000000000000000000000003886 147.0
TLS2_k127_5004189_59 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000006679 132.0
TLS2_k127_5004189_6 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 566.0
TLS2_k127_5004189_60 Tetracycline repressor protein class H - - - 0.00000000000000000000000000000001612 135.0
TLS2_k127_5004189_61 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000002416 121.0
TLS2_k127_5004189_62 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000006758 122.0
TLS2_k127_5004189_63 Lipopolysaccharide-assembly - - - 0.00000000000000000000000003717 114.0
TLS2_k127_5004189_64 Transcriptional regulator K07729 - - 0.0000000000000000000000005625 107.0
TLS2_k127_5004189_65 Transcriptional regulator PadR-like family - - - 0.00000000000000000000003254 103.0
TLS2_k127_5004189_66 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.0000000000000000000004285 102.0
TLS2_k127_5004189_67 - - - - 0.00000000000000001177 93.0
TLS2_k127_5004189_68 translation initiation factor activity K07004,K20276 - - 0.000000000000002147 90.0
TLS2_k127_5004189_69 SnoaL-like polyketide cyclase K15945 - - 0.00000000000002193 78.0
TLS2_k127_5004189_7 alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 507.0
TLS2_k127_5004189_70 COG1520 FOG WD40-like repeat - - - 0.0000000000000234 89.0
TLS2_k127_5004189_71 - - - - 0.0000000002309 73.0
TLS2_k127_5004189_73 competence protein COMEC - - - 0.000000002977 71.0
TLS2_k127_5004189_74 Cro/C1-type HTH DNA-binding domain K07727 - - 0.000000004646 61.0
TLS2_k127_5004189_75 Protein of unknown function (DUF3667) - - - 0.00000001973 65.0
TLS2_k127_5004189_76 - - - - 0.000007411 49.0
TLS2_k127_5004189_77 - - - - 0.00001158 48.0
TLS2_k127_5004189_78 - - - - 0.00001262 49.0
TLS2_k127_5004189_79 guanyl-nucleotide exchange factor activity K20276 - - 0.00002013 57.0
TLS2_k127_5004189_8 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 521.0
TLS2_k127_5004189_81 - - - - 0.0002243 51.0
TLS2_k127_5004189_82 Peptidoglycan-synthase activator LpoB - - - 0.0002248 54.0
TLS2_k127_5004189_9 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 506.0
TLS2_k127_5109144_0 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 497.0
TLS2_k127_5109144_1 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 356.0
TLS2_k127_5109144_10 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000004375 227.0
TLS2_k127_5109144_11 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000001129 202.0
TLS2_k127_5109144_12 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000000000000000000000000161 205.0
TLS2_k127_5109144_13 Alpha Beta K06889 - - 0.000000000000000000000000000000000000000000000000000004299 204.0
TLS2_k127_5109144_14 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000001538 198.0
TLS2_k127_5109144_15 GrpB protein - - - 0.00000000000000000000000000000000000000000000000002947 185.0
TLS2_k127_5109144_16 Carbon-nitrogen hydrolase K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000006042 180.0
TLS2_k127_5109144_17 Putative glycolipid-binding K09957 - - 0.00000000000000000000000000000000000000000002101 170.0
TLS2_k127_5109144_18 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000003241 160.0
TLS2_k127_5109144_19 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000002747 161.0
TLS2_k127_5109144_2 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 354.0
TLS2_k127_5109144_20 Cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000002654 145.0
TLS2_k127_5109144_21 - - - - 0.0000000000000000000000005259 111.0
TLS2_k127_5109144_22 - - - - 0.0000000000000000000001447 99.0
TLS2_k127_5109144_23 Serine aminopeptidase, S33 - - - 0.00000000000000001093 91.0
TLS2_k127_5109144_24 Cytochrome C assembly protein K02195 - - 0.00000000000000002745 87.0
TLS2_k127_5109144_25 Immunoglobulin-like domain of bacterial spore germination - - - 0.0000000001346 70.0
TLS2_k127_5109144_27 pathogenesis - - - 0.0000000592 63.0
TLS2_k127_5109144_28 - - - - 0.0000005588 59.0
TLS2_k127_5109144_29 NHL repeat - - - 0.00000156 60.0
TLS2_k127_5109144_3 Glutamine amidotransferase class-I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 308.0
TLS2_k127_5109144_4 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 293.0
TLS2_k127_5109144_5 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004214 247.0
TLS2_k127_5109144_6 B3 4 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008064 247.0
TLS2_k127_5109144_7 Diphthamide synthase - - - 0.000000000000000000000000000000000000000000000000000000000001221 223.0
TLS2_k127_5109144_8 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000002227 227.0
TLS2_k127_5109144_9 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000000000000000000000003029 211.0
TLS2_k127_51240_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 4.512e-316 992.0
TLS2_k127_51240_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002784 508.0
TLS2_k127_51240_10 pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 338.0
TLS2_k127_51240_11 4-hydroxyproline epimerase activity K01777,K12658 GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855,GO:0036361,GO:0047580,GO:0047661 5.1.1.4,5.1.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 331.0
TLS2_k127_51240_12 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 323.0
TLS2_k127_51240_13 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 291.0
TLS2_k127_51240_14 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 294.0
TLS2_k127_51240_15 helix_turn_helix, Lux Regulon K07693 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 285.0
TLS2_k127_51240_16 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002372 254.0
TLS2_k127_51240_17 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005104 253.0
TLS2_k127_51240_18 Histidine kinase K07778 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000005334 245.0
TLS2_k127_51240_19 of the major facilitator superfamily K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000004461 253.0
TLS2_k127_51240_2 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 486.0
TLS2_k127_51240_20 Protein of unknown function (DUF1460) - - - 0.000000000000000000000000000000000000000000000000000000000000129 225.0
TLS2_k127_51240_21 - - - - 0.000000000000000000000000000000000000000000000000000000000001503 218.0
TLS2_k127_51240_22 synthase homocitrate synthase family - - - 0.00000000000000000000000000000000000000000000000000000005762 200.0
TLS2_k127_51240_23 - - - - 0.0000000000000000000000000000000000000000000000000001632 193.0
TLS2_k127_51240_24 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000001264 188.0
TLS2_k127_51240_25 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000007136 187.0
TLS2_k127_51240_26 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000002667 156.0
TLS2_k127_51240_27 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000009979 153.0
TLS2_k127_51240_28 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000001849 143.0
TLS2_k127_51240_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 466.0
TLS2_k127_51240_30 heat shock protein binding - - - 0.00000000000000000000000000000003545 143.0
TLS2_k127_51240_31 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K07443 - - 0.0000000000000000000000009184 107.0
TLS2_k127_51240_32 NUDIX domain - - - 0.00000000000000000000003039 105.0
TLS2_k127_51240_33 PFAM OsmC family protein - - - 0.0000000000000000000001162 103.0
TLS2_k127_51240_34 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000006037 106.0
TLS2_k127_51240_35 PFAM HD domain - - - 0.00000000000000000001413 101.0
TLS2_k127_51240_36 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.00000000000000000004008 105.0
TLS2_k127_51240_38 XdhC and CoxI family - - - 0.000000000000000004119 87.0
TLS2_k127_51240_39 2Fe-2S iron-sulfur cluster binding domain K00302 - 1.5.3.1 0.00000000000000001822 86.0
TLS2_k127_51240_4 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000837 419.0
TLS2_k127_51240_40 hydroxylamine reductase activity K15864 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1,1.7.99.1 0.0000007465 57.0
TLS2_k127_51240_5 PFAM sodium calcium exchanger membrane region K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 392.0
TLS2_k127_51240_6 antiporter K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 374.0
TLS2_k127_51240_7 antibiotic catabolic process K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006329 363.0
TLS2_k127_51240_8 FAD dependent oxidoreductase K21061 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 348.0
TLS2_k127_51240_9 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 351.0
TLS2_k127_5158849_0 diguanylate cyclase - - - 0.0000000000000000000000000000000004516 147.0
TLS2_k127_5175314_0 iron dependent repressor K02003,K02565,K15545 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007153 411.0
TLS2_k127_5175314_1 Outer membrane protein beta-barrel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007257 256.0
TLS2_k127_5175314_2 Outer membrane protein beta-barrel family - - - 0.00000000000002835 86.0
TLS2_k127_5210766_0 CarboxypepD_reg-like domain - - - 4.13e-256 829.0
TLS2_k127_5210766_1 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 531.0
TLS2_k127_5210766_10 EamA-like transporter family - - - 0.00000000000000000000000000000000001504 148.0
TLS2_k127_5210766_11 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000001854 141.0
TLS2_k127_5210766_12 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000997 134.0
TLS2_k127_5210766_13 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000000002388 94.0
TLS2_k127_5210766_15 Domain of unknown function (DUF4397) - - - 0.0000000009018 70.0
TLS2_k127_5210766_16 - - - - 0.000003158 55.0
TLS2_k127_5210766_17 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0008814 51.0
TLS2_k127_5210766_2 secondary active sulfate transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 458.0
TLS2_k127_5210766_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 420.0
TLS2_k127_5210766_4 cobalamin-transporting ATPase activity K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 405.0
TLS2_k127_5210766_5 Pfam:SusD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009725 399.0
TLS2_k127_5210766_6 FecCD transport family K02013,K02015 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000057 287.0
TLS2_k127_5210766_7 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000000000000000000000000003128 250.0
TLS2_k127_5210766_8 Abc transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000002441 219.0
TLS2_k127_5210766_9 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000007253 216.0
TLS2_k127_5291326_0 FtsX-like permease family K02004 - - 1.798e-234 749.0
TLS2_k127_5291326_1 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008645 399.0
TLS2_k127_5291326_10 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000000000001148 183.0
TLS2_k127_5291326_11 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000005533 158.0
TLS2_k127_5291326_12 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000009725 145.0
TLS2_k127_5291326_13 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000002936 108.0
TLS2_k127_5291326_14 Carboxypeptidase regulatory-like domain K02014 - - 0.00000000000000000000003485 109.0
TLS2_k127_5291326_15 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000689 107.0
TLS2_k127_5291326_16 diguanylate cyclase - - - 0.000000000000000000008663 108.0
TLS2_k127_5291326_17 Dodecin K09165 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000003635 79.0
TLS2_k127_5291326_18 CBS domain K07182 - - 0.00000000005157 68.0
TLS2_k127_5291326_19 Universal stress protein family - - - 0.0008605 49.0
TLS2_k127_5291326_2 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007659 392.0
TLS2_k127_5291326_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 409.0
TLS2_k127_5291326_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 356.0
TLS2_k127_5291326_5 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000682 301.0
TLS2_k127_5291326_6 HlyD family secretion protein K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007813 270.0
TLS2_k127_5291326_7 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000003794 248.0
TLS2_k127_5291326_8 BON domain K04065 - - 0.0000000000000000000000000000000000000000000000000000000005007 209.0
TLS2_k127_5291326_9 Erythromycin esterase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000001255 201.0
TLS2_k127_5495466_0 RmlD substrate binding domain K00067 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000004215 224.0
TLS2_k127_5495466_1 Transmembrane and TPR repeat-containing protein - GO:0001763,GO:0002009,GO:0003401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006950,GO:0007275,GO:0008150,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0012505,GO:0019222,GO:0030154,GO:0030162,GO:0030323,GO:0030324,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0033554,GO:0034976,GO:0035239,GO:0035295,GO:0040007,GO:0042176,GO:0042692,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045732,GO:0045862,GO:0048286,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048729,GO:0048731,GO:0048747,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051716,GO:0055001,GO:0055002,GO:0060255,GO:0060425,GO:0060429,GO:0060441,GO:0060447,GO:0060541,GO:0060560,GO:0060562,GO:0060602,GO:0061061,GO:0061136,GO:0061138,GO:0065007,GO:0080090,GO:1901800,GO:1903050,GO:1903052,GO:1903362,GO:1903364 - 0.00000000000000000000000000002403 136.0
TLS2_k127_5495466_2 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000001523 97.0
TLS2_k127_5495466_3 Prokaryotic N-terminal methylation motif - - - 0.000000000000000008986 91.0
TLS2_k127_5495466_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00002359 57.0
TLS2_k127_5503964_0 Aldo keto - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 416.0
TLS2_k127_5503964_1 PFAM secretion protein HlyD family protein - - - 0.000000000000000000000000000000000000248 156.0
TLS2_k127_5503964_3 - - - - 0.0001574 51.0
TLS2_k127_5534646_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1132.0
TLS2_k127_5534646_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 8.149e-309 971.0
TLS2_k127_5534646_10 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 505.0
TLS2_k127_5534646_11 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 482.0
TLS2_k127_5534646_12 Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 452.0
TLS2_k127_5534646_13 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 430.0
TLS2_k127_5534646_14 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042,K17468 - 2.9.1.1,4.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 404.0
TLS2_k127_5534646_15 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 368.0
TLS2_k127_5534646_16 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 330.0
TLS2_k127_5534646_17 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 298.0
TLS2_k127_5534646_18 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002198 244.0
TLS2_k127_5534646_19 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000001816 233.0
TLS2_k127_5534646_2 HELICc2 K03722 - 3.6.4.12 2.632e-242 776.0
TLS2_k127_5534646_20 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002876 241.0
TLS2_k127_5534646_21 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.000000000000000000000000000000000000000000000000000000000000002129 237.0
TLS2_k127_5534646_22 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000002544 208.0
TLS2_k127_5534646_23 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000875 207.0
TLS2_k127_5534646_24 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000001468 188.0
TLS2_k127_5534646_25 CcmB protein K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.0000000000000000000000000000000000000000000000001029 188.0
TLS2_k127_5534646_26 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000001493 185.0
TLS2_k127_5534646_27 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000002426 170.0
TLS2_k127_5534646_28 metallo-beta-lactamase - - - 0.00000000000000000000000000000000000000000001275 171.0
TLS2_k127_5534646_29 D,D-heptose 1,7-bisphosphate phosphatase K03273,K15669 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 2.7.7.71,3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000003655 164.0
TLS2_k127_5534646_3 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 2.486e-231 731.0
TLS2_k127_5534646_30 self proteolysis - - - 0.00000000000000000000000000000000000000000737 178.0
TLS2_k127_5534646_31 Iron-sulphur cluster biosynthesis - - - 0.00000000000000000000000000000000000000002046 154.0
TLS2_k127_5534646_32 Redoxin K02199 - - 0.000000000000000000000000000000000001009 151.0
TLS2_k127_5534646_33 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000001161 143.0
TLS2_k127_5534646_34 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000003811 139.0
TLS2_k127_5534646_35 COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000000003502 127.0
TLS2_k127_5534646_36 WHG domain - - - 0.00000000000000000000000001361 119.0
TLS2_k127_5534646_37 subunit of a heme lyase K02200 - - 0.0000000000000000000000002984 111.0
TLS2_k127_5534646_38 Bacterial Ig-like domain - - - 0.000000000000001128 89.0
TLS2_k127_5534646_39 BON domain - - - 0.000000000156 69.0
TLS2_k127_5534646_4 Cytochrome C assembly protein K02198,K04016 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - 1.173e-206 662.0
TLS2_k127_5534646_40 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division K20543 - - 0.00000000241 70.0
TLS2_k127_5534646_41 nuclear chromosome segregation - - - 0.00000002255 59.0
TLS2_k127_5534646_5 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008874 537.0
TLS2_k127_5534646_6 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 518.0
TLS2_k127_5534646_7 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 522.0
TLS2_k127_5534646_8 Na H antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 527.0
TLS2_k127_5534646_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 507.0
TLS2_k127_5668389_0 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000001803 235.0
TLS2_k127_5884501_0 Belongs to the peptidase M16 family K07263 - - 2.281e-301 951.0
TLS2_k127_5884501_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000005684 88.0
TLS2_k127_5903267_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.293e-268 852.0
TLS2_k127_5903267_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006984 591.0
TLS2_k127_5903267_10 AMIN domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 340.0
TLS2_k127_5903267_11 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 327.0
TLS2_k127_5903267_12 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000001905 257.0
TLS2_k127_5903267_13 Domain of unknown function DUF21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001958 257.0
TLS2_k127_5903267_14 histidine kinase, HAMP - - - 0.00000000000000000000000000000000000000000000000000000000002137 221.0
TLS2_k127_5903267_15 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000003246 195.0
TLS2_k127_5903267_16 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000001573 177.0
TLS2_k127_5903267_17 amine dehydrogenase activity - - - 0.00000000000000000000000000000000003615 156.0
TLS2_k127_5903267_18 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000001081 133.0
TLS2_k127_5903267_19 Fimbrial assembly protein (PilN) - - - 0.000000000000000000000006094 110.0
TLS2_k127_5903267_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 560.0
TLS2_k127_5903267_20 - - - - 0.000000000000000000005784 102.0
TLS2_k127_5903267_21 - - - - 0.0000000009215 70.0
TLS2_k127_5903267_22 Pilus assembly protein PilO K02664 - - 0.000000004019 66.0
TLS2_k127_5903267_23 Prokaryotic N-terminal methylation motif K02457 - - 0.000001864 56.0
TLS2_k127_5903267_3 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 492.0
TLS2_k127_5903267_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 482.0
TLS2_k127_5903267_5 response regulator K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 475.0
TLS2_k127_5903267_6 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 479.0
TLS2_k127_5903267_7 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 427.0
TLS2_k127_5903267_8 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 427.0
TLS2_k127_5903267_9 Type IV pilus assembly protein PilM; K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006983 366.0
TLS2_k127_5971403_0 dehydrogenases and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 484.0
TLS2_k127_5971403_1 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003286 391.0
TLS2_k127_5971403_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000002229 214.0
TLS2_k127_5971403_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000008523 192.0
TLS2_k127_5971403_4 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000001536 192.0
TLS2_k127_5971403_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000001009 163.0
TLS2_k127_6042358_0 Bacterial protein of unknown function (DUF885) - - - 2.246e-199 641.0
TLS2_k127_6042358_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 589.0
TLS2_k127_6042358_10 ORF located using Blastx - - - 0.000002915 59.0
TLS2_k127_6042358_2 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 438.0
TLS2_k127_6042358_3 transmembrane transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 400.0
TLS2_k127_6042358_4 Ornithine cyclodeaminase/mu-crystallin family K19742 - 1.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 355.0
TLS2_k127_6042358_5 Belongs to the DapA family K01714,K21062 - 3.5.4.22,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 353.0
TLS2_k127_6042358_6 FCD - - - 0.000000000000000000000000000000000000000000000000000001304 201.0
TLS2_k127_6042358_7 SMART phosphoesterase PHP domain protein K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000002391 188.0
TLS2_k127_6042358_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000001167 102.0
TLS2_k127_6042358_9 Phosphoenolpyruvate hydrolase-like - - - 0.000000004568 64.0
TLS2_k127_626082_0 glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 313.0
TLS2_k127_626082_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002939 277.0
TLS2_k127_626082_2 Hexosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000104 282.0
TLS2_k127_626082_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000000000000000000000000000000000000000003253 177.0
TLS2_k127_6395248_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 436.0
TLS2_k127_6395248_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 321.0
TLS2_k127_6395248_2 Predicted Zn-dependent protease (DUF2268) - - - 0.000000000000000000000000000000000000000000000000000002945 216.0
TLS2_k127_6434125_0 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 379.0
TLS2_k127_6434125_1 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000009631 246.0
TLS2_k127_6434125_2 Helix-turn-helix domain - - - 0.00000000007074 66.0
TLS2_k127_6434125_3 AAA domain - - - 0.00007036 55.0
TLS2_k127_6434125_4 Transcriptional Coactivator p15 (PC4) - GO:0003674,GO:0003712,GO:0003713,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005667,GO:0006355,GO:0006357,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043254,GO:0044087,GO:0044089,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0045944,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0060260,GO:0060261,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.0002115 47.0
TLS2_k127_6516208_0 General secretory system II protein E domain protein K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 597.0
TLS2_k127_6516208_1 RNA polymerase binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009431 617.0
TLS2_k127_6516208_10 TIGRFAM Competence protein ComEA, helix-hairpin-helix - - - 0.0000000000006296 78.0
TLS2_k127_6516208_11 ComEA protein K02237 - - 0.00000003934 63.0
TLS2_k127_6516208_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005432 563.0
TLS2_k127_6516208_3 Type II secretion system (T2SS), protein F K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 514.0
TLS2_k127_6516208_4 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008642 494.0
TLS2_k127_6516208_5 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000199 286.0
TLS2_k127_6516208_6 Predicted permease YjgP/YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000001072 240.0
TLS2_k127_6516208_7 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000002386 234.0
TLS2_k127_6516208_8 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000001204 201.0
TLS2_k127_6516208_9 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.0000000000000001596 91.0
TLS2_k127_6567438_0 Zinc-uptake complex component A periplasmic K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009523 397.0
TLS2_k127_6567438_1 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000004202 245.0
TLS2_k127_6567438_2 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000136 146.0
TLS2_k127_658855_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 503.0
TLS2_k127_658855_1 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000004748 138.0
TLS2_k127_6709402_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000304 269.0
TLS2_k127_6709402_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000006414 165.0
TLS2_k127_6776135_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 2.09e-321 998.0
TLS2_k127_6776135_1 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 603.0
TLS2_k127_6776135_10 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 337.0
TLS2_k127_6776135_11 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 312.0
TLS2_k127_6776135_12 COG0668 Small-conductance mechanosensitive channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 312.0
TLS2_k127_6776135_13 Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate K00674,K05822 - 2.3.1.117,2.3.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002484 273.0
TLS2_k127_6776135_14 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002941 276.0
TLS2_k127_6776135_15 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000004019 271.0
TLS2_k127_6776135_16 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000001003 245.0
TLS2_k127_6776135_17 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000002723 251.0
TLS2_k127_6776135_18 Dihydrodipicolinate synthetase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002315 242.0
TLS2_k127_6776135_19 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000004397 209.0
TLS2_k127_6776135_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 600.0
TLS2_k127_6776135_20 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000002584 196.0
TLS2_k127_6776135_21 Acid phosphatase homologues - - - 0.0000000000000000000000000000000000000000000000012 182.0
TLS2_k127_6776135_22 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000004517 188.0
TLS2_k127_6776135_23 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000001297 188.0
TLS2_k127_6776135_24 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788,K14153 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000007978 176.0
TLS2_k127_6776135_25 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000005226 171.0
TLS2_k127_6776135_26 Glyoxalase-like domain K05606 - 5.1.99.1 0.0000000000000000000000000000000008997 134.0
TLS2_k127_6776135_27 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000003959 129.0
TLS2_k127_6776135_29 4-vinyl reductase, 4VR - - - 0.0000000000000000000000008516 110.0
TLS2_k127_6776135_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 581.0
TLS2_k127_6776135_30 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000009039 106.0
TLS2_k127_6776135_31 DNA-binding transcription factor activity - - - 0.0000000000000000000001531 102.0
TLS2_k127_6776135_32 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000002816 102.0
TLS2_k127_6776135_33 - - - - 0.000000061 58.0
TLS2_k127_6776135_34 Domain of unknown function (DUF4249) - - - 0.00000008394 64.0
TLS2_k127_6776135_35 gas vesicle protein - - - 0.000003982 53.0
TLS2_k127_6776135_36 domain, Protein K13735,K20276 - - 0.0000189 58.0
TLS2_k127_6776135_37 Protein of unknown function (DUF3343) - - - 0.0007838 48.0
TLS2_k127_6776135_4 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 524.0
TLS2_k127_6776135_5 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 490.0
TLS2_k127_6776135_6 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 481.0
TLS2_k127_6776135_7 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity K00697,K13057,K20436 - 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008311 470.0
TLS2_k127_6776135_8 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 452.0
TLS2_k127_6776135_9 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 353.0
TLS2_k127_6801922_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 587.0
TLS2_k127_6801922_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009586 532.0
TLS2_k127_6801922_10 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000001882 270.0
TLS2_k127_6801922_11 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.000000000000000000000000000000000000000000000000000000000000000002096 234.0
TLS2_k127_6801922_12 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000001364 221.0
TLS2_k127_6801922_13 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000003629 211.0
TLS2_k127_6801922_14 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 0.000000000000000000000000000000000000000000000000001541 193.0
TLS2_k127_6801922_15 EXOIII K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000005321 188.0
TLS2_k127_6801922_16 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000006817 188.0
TLS2_k127_6801922_17 Cysteine-rich motif following a subset of SET domains K07117 - - 0.0000000000000000000000000000000000000000000000002384 181.0
TLS2_k127_6801922_18 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000002995 173.0
TLS2_k127_6801922_19 STAS domain K04749 - - 0.0000000000000000000000000000000000000000000004041 177.0
TLS2_k127_6801922_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 522.0
TLS2_k127_6801922_20 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000711 162.0
TLS2_k127_6801922_21 - - - - 0.000000000000000000000000000000005066 131.0
TLS2_k127_6801922_22 - - - - 0.0000000000000000000000000002395 118.0
TLS2_k127_6801922_23 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.000000000000000000000007357 107.0
TLS2_k127_6801922_24 CAAX amino terminal protease family K07052 - - 0.0000000000000000000005919 108.0
TLS2_k127_6801922_25 Biotin biosynthesis protein BioY of Proteobacteria UniRef RepID B8F6V1_HAEPS K03523 - - 0.0000000000000000000006469 102.0
TLS2_k127_6801922_26 Histidine kinase-like ATPases - - - 0.000007497 58.0
TLS2_k127_6801922_27 Septum formation initiator K05589 - - 0.00001698 54.0
TLS2_k127_6801922_3 C4-dicarboxylate anaerobic carrier - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 512.0
TLS2_k127_6801922_4 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 484.0
TLS2_k127_6801922_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 364.0
TLS2_k127_6801922_6 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 351.0
TLS2_k127_6801922_7 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 329.0
TLS2_k127_6801922_8 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 322.0
TLS2_k127_6801922_9 Amidinotransferase K01478 - 3.5.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001208 290.0
TLS2_k127_6946472_0 AcrB/AcrD/AcrF family K07787,K15726 - - 0.0 1444.0
TLS2_k127_6946472_1 YHS domain K01533 - 3.6.3.4 0.0 1006.0
TLS2_k127_6946472_10 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 491.0
TLS2_k127_6946472_11 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 432.0
TLS2_k127_6946472_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 384.0
TLS2_k127_6946472_13 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 357.0
TLS2_k127_6946472_14 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 348.0
TLS2_k127_6946472_15 Signal Transduction Histidine Kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 361.0
TLS2_k127_6946472_16 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 324.0
TLS2_k127_6946472_17 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008686 319.0
TLS2_k127_6946472_18 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 302.0
TLS2_k127_6946472_19 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 315.0
TLS2_k127_6946472_2 ABC transporter transmembrane region K11085 - - 1.212e-294 923.0
TLS2_k127_6946472_20 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009175 275.0
TLS2_k127_6946472_21 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008407 247.0
TLS2_k127_6946472_22 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001415 232.0
TLS2_k127_6946472_23 Histidine kinase K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000002459 246.0
TLS2_k127_6946472_24 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000003011 208.0
TLS2_k127_6946472_25 Domain of unknown function (DUF305) - - - 0.00000000000000000000000000000000000000000000000000000000003735 214.0
TLS2_k127_6946472_26 ArsR family transcriptional regulator - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010288,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032791,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097063,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000004798 186.0
TLS2_k127_6946472_27 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000001171 184.0
TLS2_k127_6946472_28 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000001073 179.0
TLS2_k127_6946472_29 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000000002017 174.0
TLS2_k127_6946472_3 LVIVD repeat - - - 1.837e-268 840.0
TLS2_k127_6946472_30 YCII-related domain - - - 0.000000000000000000000000000000000000000000001393 168.0
TLS2_k127_6946472_31 Evidence 4 Homologs of previously reported genes of K15977 - - 0.000000000000000000000000000000000000000002362 161.0
TLS2_k127_6946472_32 TAP-like protein - - - 0.000000000000000000000000000000000000000003881 176.0
TLS2_k127_6946472_33 YCII-related domain - - - 0.00000000000000000000000000000000000000001296 155.0
TLS2_k127_6946472_34 - - - - 0.000000000000000000000000000000000000001703 162.0
TLS2_k127_6946472_35 glyoxalase III activity - - - 0.000000000000000000000000000000000000001797 157.0
TLS2_k127_6946472_36 - K04517 - 1.3.1.12 0.000000000000000000000000000000000000006768 151.0
TLS2_k127_6946472_37 PFAM Peptidase M23 - - - 0.00000000000000000000000000000000000001304 157.0
TLS2_k127_6946472_38 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000004458 146.0
TLS2_k127_6946472_39 YCII-related domain - - - 0.000000000000000000000000000000000008132 145.0
TLS2_k127_6946472_4 serine-type peptidase activity K01990,K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 2.55e-243 783.0
TLS2_k127_6946472_40 - - - - 0.00000000000000000000000000000000122 140.0
TLS2_k127_6946472_41 YjbR - - - 0.0000000000000000000000000000002589 129.0
TLS2_k127_6946472_42 Transcriptional - - - 0.000000000000000000000000001284 128.0
TLS2_k127_6946472_43 pilus assembly protein, PilZ - - - 0.0000000000000000000000003565 117.0
TLS2_k127_6946472_44 transcriptional regulator PadR family - - - 0.00000000000000000000265 97.0
TLS2_k127_6946472_46 PIN domain - - - 0.000000000000867 70.0
TLS2_k127_6946472_47 PIN domain - - - 0.0001959 44.0
TLS2_k127_6946472_48 Smr domain - - - 0.000229 51.0
TLS2_k127_6946472_49 response to abiotic stimulus K06867 - - 0.0006339 46.0
TLS2_k127_6946472_5 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 611.0
TLS2_k127_6946472_6 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 568.0
TLS2_k127_6946472_7 Sigma-70 region 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 555.0
TLS2_k127_6946472_8 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 559.0
TLS2_k127_6946472_9 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 546.0
TLS2_k127_6999255_0 ERAP1-like C-terminal domain K01256 - 3.4.11.2 2.598e-286 910.0
TLS2_k127_6999255_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.669e-254 792.0
TLS2_k127_6999255_10 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 578.0
TLS2_k127_6999255_11 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 550.0
TLS2_k127_6999255_12 Dehydrogenase K00248,K09478 - 1.3.8.1,1.3.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009919 540.0
TLS2_k127_6999255_13 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 492.0
TLS2_k127_6999255_14 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 492.0
TLS2_k127_6999255_15 PFAM Type II secretion system protein E K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 450.0
TLS2_k127_6999255_16 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 432.0
TLS2_k127_6999255_17 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 429.0
TLS2_k127_6999255_18 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 413.0
TLS2_k127_6999255_19 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 410.0
TLS2_k127_6999255_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 3.016e-237 766.0
TLS2_k127_6999255_20 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 383.0
TLS2_k127_6999255_21 heat shock protein binding K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 374.0
TLS2_k127_6999255_22 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 386.0
TLS2_k127_6999255_23 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 359.0
TLS2_k127_6999255_24 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 355.0
TLS2_k127_6999255_25 Peptidase family M23 K21472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 362.0
TLS2_k127_6999255_26 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 338.0
TLS2_k127_6999255_27 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 340.0
TLS2_k127_6999255_28 Amidohydrolase family K05603 - 3.5.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 333.0
TLS2_k127_6999255_29 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 315.0
TLS2_k127_6999255_3 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 1.775e-225 709.0
TLS2_k127_6999255_30 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 301.0
TLS2_k127_6999255_31 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 306.0
TLS2_k127_6999255_32 A G-specific adenine glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 293.0
TLS2_k127_6999255_33 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002492 302.0
TLS2_k127_6999255_34 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005897 281.0
TLS2_k127_6999255_35 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000108 276.0
TLS2_k127_6999255_36 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001515 272.0
TLS2_k127_6999255_37 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008909 272.0
TLS2_k127_6999255_38 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002898 252.0
TLS2_k127_6999255_39 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000199 235.0
TLS2_k127_6999255_4 4Fe-4S dicluster domain K00184 - - 1.595e-218 718.0
TLS2_k127_6999255_40 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000585 254.0
TLS2_k127_6999255_41 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000008884 252.0
TLS2_k127_6999255_42 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000009275 248.0
TLS2_k127_6999255_43 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001159 254.0
TLS2_k127_6999255_44 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000002704 246.0
TLS2_k127_6999255_45 Pfam Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000166 235.0
TLS2_k127_6999255_46 - - - - 0.00000000000000000000000000000000000000000000000000000000006526 222.0
TLS2_k127_6999255_47 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.0000000000000000000000000000000000000000000000000000000005114 218.0
TLS2_k127_6999255_48 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000003806 208.0
TLS2_k127_6999255_49 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.0000000000000000000000000000000000000000000000000000003194 209.0
TLS2_k127_6999255_5 acyl-CoA dehydrogenase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 5.623e-212 675.0
TLS2_k127_6999255_50 Glucose inhibited division protein A K21401 - 1.3.99.38 0.0000000000000000000000000000000000000000000000000000003521 211.0
TLS2_k127_6999255_51 Acyl-CoA reductase (LuxC) - - - 0.000000000000000000000000000000000000000000000000000001509 211.0
TLS2_k127_6999255_52 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000001885 198.0
TLS2_k127_6999255_53 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.00000000000000000000000000000000000000000000000001091 191.0
TLS2_k127_6999255_54 - - - - 0.00000000000000000000000000000000000000000000000001168 188.0
TLS2_k127_6999255_55 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000009255 186.0
TLS2_k127_6999255_56 Metalloenzyme superfamily - - - 0.0000000000000000000000000000000000000000000000001701 191.0
TLS2_k127_6999255_57 cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000000001177 200.0
TLS2_k127_6999255_58 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000002703 174.0
TLS2_k127_6999255_59 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000005285 171.0
TLS2_k127_6999255_6 Peptidase dimerisation domain - - - 6.687e-199 633.0
TLS2_k127_6999255_60 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 0.00000000000000000000000000000000000000000000915 173.0
TLS2_k127_6999255_61 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000003092 170.0
TLS2_k127_6999255_62 Tetratricopeptide repeat K08309 - - 0.00000000000000000000000000000000000000000005239 184.0
TLS2_k127_6999255_63 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - 0.000000000000000000000000000000000000000001036 161.0
TLS2_k127_6999255_64 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000007444 160.0
TLS2_k127_6999255_65 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000001454 159.0
TLS2_k127_6999255_66 surface antigen K07001,K07277 - - 0.0000000000000000000000000000000000000006881 168.0
TLS2_k127_6999255_67 Methyltransferase domain - - - 0.0000000000000000000000000000000000000006983 157.0
TLS2_k127_6999255_68 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000001616 154.0
TLS2_k127_6999255_69 NUDIX hydrolase - - - 0.00000000000000000000000000000000000004257 153.0
TLS2_k127_6999255_7 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 8.164e-198 627.0
TLS2_k127_6999255_70 SnoaL-like domain - - - 0.00000000000000000000000000000000002143 140.0
TLS2_k127_6999255_71 Protein of unknown function (DUF3341) - - - 0.00000000000000000000000000000000509 137.0
TLS2_k127_6999255_72 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000518 138.0
TLS2_k127_6999255_73 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000002442 137.0
TLS2_k127_6999255_74 Gas vesicle protein K - - - 0.00000000000000000000000000000009988 127.0
TLS2_k127_6999255_75 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000001119 123.0
TLS2_k127_6999255_76 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.0000000000000000000000000005277 117.0
TLS2_k127_6999255_77 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.0000000000000000000000000007006 115.0
TLS2_k127_6999255_78 Cold shock K03704 - - 0.0000000000000000000000000009672 113.0
TLS2_k127_6999255_79 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000005325 111.0
TLS2_k127_6999255_8 M61 glycyl aminopeptidase - - - 1.223e-195 632.0
TLS2_k127_6999255_81 Gas vesicle - - - 0.0000000000000000000000009925 115.0
TLS2_k127_6999255_82 - - - - 0.000000000000000000000007648 109.0
TLS2_k127_6999255_83 lytic transglycosylase activity - - - 0.000000000000000003905 94.0
TLS2_k127_6999255_84 RNA-binding protein K07574 - - 0.0000000000000001546 92.0
TLS2_k127_6999255_85 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000002214 89.0
TLS2_k127_6999255_86 Domain of unknown function (DUF4126) - - - 0.0000000000000002797 90.0
TLS2_k127_6999255_87 ABC-2 family transporter protein - - - 0.00000000000005698 82.0
TLS2_k127_6999255_88 PRC-barrel domain protein - - - 0.0000000000004816 79.0
TLS2_k127_6999255_89 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000101 76.0
TLS2_k127_6999255_9 protein histidine kinase activity K03407,K07678 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 594.0
TLS2_k127_6999255_90 - - - - 0.000000000001965 68.0
TLS2_k127_6999255_91 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.000000000002576 69.0
TLS2_k127_6999255_92 amine dehydrogenase activity - - - 0.00002103 57.0
TLS2_k127_6999255_93 amine dehydrogenase activity - - - 0.00003691 57.0
TLS2_k127_6999255_94 Histidine kinase - - - 0.00004371 53.0
TLS2_k127_6999255_95 Protein of unknown function, DUF481 K07283 - - 0.0005497 51.0
TLS2_k127_7056474_0 cellulose binding - - - 0.0 1150.0
TLS2_k127_7056474_1 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 1.499e-255 806.0
TLS2_k127_7056474_10 sigma factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 572.0
TLS2_k127_7056474_100 Domain of unknown function (DUF4154) - - - 0.000002676 58.0
TLS2_k127_7056474_101 - - - - 0.000006211 52.0
TLS2_k127_7056474_103 - - - - 0.00004166 50.0
TLS2_k127_7056474_104 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0001131 55.0
TLS2_k127_7056474_11 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 568.0
TLS2_k127_7056474_12 receptor K16091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 586.0
TLS2_k127_7056474_13 ABC transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 559.0
TLS2_k127_7056474_14 Peptidase, M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 526.0
TLS2_k127_7056474_15 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 529.0
TLS2_k127_7056474_16 inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 505.0
TLS2_k127_7056474_17 N,N-dimethylaniline monooxygenase activity K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 473.0
TLS2_k127_7056474_18 ketosteroid isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 466.0
TLS2_k127_7056474_19 PFAM amino acid permease-associated region K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 439.0
TLS2_k127_7056474_2 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 3.063e-234 754.0
TLS2_k127_7056474_20 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004175 425.0
TLS2_k127_7056474_21 The M ring may be actively involved in energy transduction K02409 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 422.0
TLS2_k127_7056474_22 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07713,K07714,K19641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 426.0
TLS2_k127_7056474_23 Flagellar basal body protein FlaE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007417 417.0
TLS2_k127_7056474_24 TonB-dependent Receptor Plug Domain K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 426.0
TLS2_k127_7056474_25 Domains REC, sigma54 interaction, HTH8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 417.0
TLS2_k127_7056474_26 peptidase dimerisation domain protein K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 409.0
TLS2_k127_7056474_27 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 413.0
TLS2_k127_7056474_28 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006528 402.0
TLS2_k127_7056474_29 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 404.0
TLS2_k127_7056474_3 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.192e-219 693.0
TLS2_k127_7056474_30 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005112 401.0
TLS2_k127_7056474_31 FliG N-terminal domain K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 368.0
TLS2_k127_7056474_32 PFAM TrkA-N domain protein K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 358.0
TLS2_k127_7056474_33 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 368.0
TLS2_k127_7056474_34 Flagella basal body rod protein K02392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 345.0
TLS2_k127_7056474_35 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 350.0
TLS2_k127_7056474_36 MotA/TolQ/ExbB proton channel family K02556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 338.0
TLS2_k127_7056474_37 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 332.0
TLS2_k127_7056474_38 Flagellar motor switch protein FliM K02416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 326.0
TLS2_k127_7056474_39 Plays a role in the flagellum-specific transport system K02419 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 320.0
TLS2_k127_7056474_4 Acyl-CoA oxidase K00232 - 1.3.3.6 9.043e-210 677.0
TLS2_k127_7056474_40 conserved protein (DUF2183) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 319.0
TLS2_k127_7056474_41 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 320.0
TLS2_k127_7056474_42 FlhB HrpN YscU SpaS Family K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 295.0
TLS2_k127_7056474_43 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001614 298.0
TLS2_k127_7056474_44 ABC-type spermidine putrescine transport systems, ATPase components K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000003129 290.0
TLS2_k127_7056474_45 Flagella basal body rod protein K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001165 267.0
TLS2_k127_7056474_46 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009406 255.0
TLS2_k127_7056474_47 Sigma-70, region 4 K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001651 253.0
TLS2_k127_7056474_48 Nicotinamidase K08281 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000003845 248.0
TLS2_k127_7056474_49 Predicted membrane protein (DUF2231) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008866 250.0
TLS2_k127_7056474_5 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 2.11e-207 650.0
TLS2_k127_7056474_50 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001417 255.0
TLS2_k127_7056474_51 electron transfer activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000002094 237.0
TLS2_k127_7056474_52 Flagella basal body rod protein K02392 - - 0.00000000000000000000000000000000000000000000000000000000000000007076 230.0
TLS2_k127_7056474_53 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000003595 234.0
TLS2_k127_7056474_54 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000003416 227.0
TLS2_k127_7056474_55 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.000000000000000000000000000000000000000000000000000000001018 216.0
TLS2_k127_7056474_56 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000000001378 209.0
TLS2_k127_7056474_57 Bacterial export proteins, family 1 K02421 - - 0.00000000000000000000000000000000000000000000000000000005377 205.0
TLS2_k127_7056474_58 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000001082 199.0
TLS2_k127_7056474_59 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000009955 201.0
TLS2_k127_7056474_6 Bacterial regulatory protein, Fis family - - - 1.749e-197 625.0
TLS2_k127_7056474_60 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000007544 189.0
TLS2_k127_7056474_61 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000003656 184.0
TLS2_k127_7056474_62 Domain of unknown function (DUF4105) - - - 0.00000000000000000000000000000000000000000000004263 181.0
TLS2_k127_7056474_63 - - - - 0.00000000000000000000000000000000000000000000009091 189.0
TLS2_k127_7056474_64 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02397 - - 0.0000000000000000000000000000000000000000000001292 179.0
TLS2_k127_7056474_65 Flagella basal body rod protein K02388 - - 0.000000000000000000000000000000000000000000008496 170.0
TLS2_k127_7056474_66 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000001005 179.0
TLS2_k127_7056474_67 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000000000000000000000000000001141 164.0
TLS2_k127_7056474_68 Penicillinase repressor - - - 0.00000000000000000000000000000000000000001031 159.0
TLS2_k127_7056474_69 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000000000001634 155.0
TLS2_k127_7056474_7 ATP synthase alpha/beta family, beta-barrel domain K02412 - 3.6.3.14 1.948e-196 621.0
TLS2_k127_7056474_70 OmpA family - - - 0.000000000000000000000000000000000000002404 155.0
TLS2_k127_7056474_71 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.000000000000000000000000000000000001129 148.0
TLS2_k127_7056474_72 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000000000000000000000000000000000001301 148.0
TLS2_k127_7056474_73 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.000000000000000000000000000000000004569 154.0
TLS2_k127_7056474_74 ArsC family - - - 0.000000000000000000000000000000000009152 152.0
TLS2_k127_7056474_75 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000001433 141.0
TLS2_k127_7056474_76 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.000000000000000000000000000001561 136.0
TLS2_k127_7056474_77 Bacterial export proteins, family 3 K02420 - - 0.000000000000000000000000001443 115.0
TLS2_k127_7056474_78 Flagellar protein FliS K02422 - - 0.00000000000000000000000006625 113.0
TLS2_k127_7056474_79 bacterial-type flagellum-dependent cell motility K02387 - - 0.0000000000000000000000004558 110.0
TLS2_k127_7056474_8 Vacuole effluxer Atg22 like K06902 - - 4.158e-194 615.0
TLS2_k127_7056474_80 Flagellar assembly protein FliH K02411 - - 0.00000000000000000000001212 111.0
TLS2_k127_7056474_81 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000006668 100.0
TLS2_k127_7056474_82 Rod binding protein K02395 - - 0.00000000000000009525 92.0
TLS2_k127_7056474_83 negative regulation of transcription, DNA-templated - - - 0.0000000000000001156 85.0
TLS2_k127_7056474_84 PFAM blue (type 1) copper domain protein - - - 0.000000000000000589 84.0
TLS2_k127_7056474_85 Flagellar FliJ protein K02413 - - 0.00000000000002194 83.0
TLS2_k127_7056474_86 Flagellar hook-basal body complex protein FliE K02408 - - 0.00000000000008967 76.0
TLS2_k127_7056474_87 - - - - 0.00000000000012 83.0
TLS2_k127_7056474_88 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.000000000007646 75.0
TLS2_k127_7056474_89 cell adhesion involved in biofilm formation - - - 0.000000000007805 76.0
TLS2_k127_7056474_9 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008074 581.0
TLS2_k127_7056474_90 - - - - 0.00000000005807 70.0
TLS2_k127_7056474_91 TIGRFAM flagellar biosynthetic protein FliS K02422 - - 0.00000000005904 68.0
TLS2_k127_7056474_92 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944 - 0.0000000002941 66.0
TLS2_k127_7056474_93 Outer membrane protein beta-barrel domain - - - 0.0000000003909 69.0
TLS2_k127_7056474_94 FlgN protein - - - 0.000000001037 65.0
TLS2_k127_7056474_95 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.000000001218 67.0
TLS2_k127_7056474_96 Cellobiose phosphorylase K13688 - - 0.0000001062 55.0
TLS2_k127_7056474_97 Anti-sigma-28 factor, FlgM K02398 - - 0.000001013 56.0
TLS2_k127_7056474_98 PRC-barrel domain - - - 0.00000117 57.0
TLS2_k127_7056474_99 - - - - 0.000001651 56.0
TLS2_k127_7147465_0 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 2.023e-227 711.0
TLS2_k127_7147465_1 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 571.0
TLS2_k127_7147465_10 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 361.0
TLS2_k127_7147465_11 ATPases associated with a variety of cellular activities K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 318.0
TLS2_k127_7147465_12 peptidase dimerisation domain protein K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000009114 273.0
TLS2_k127_7147465_13 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.0000000000000000000000000000000000000000000000000000257 195.0
TLS2_k127_7147465_14 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000003617 204.0
TLS2_k127_7147465_15 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000000000000001643 186.0
TLS2_k127_7147465_16 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000001379 174.0
TLS2_k127_7147465_17 4Fe-4S single cluster domain K07001 - - 0.00000000000000000000000000000000000000000006811 170.0
TLS2_k127_7147465_18 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000007396 163.0
TLS2_k127_7147465_19 Nitrogen fixation protein NifU K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.0000000000000000000000000000000000000000001083 166.0
TLS2_k127_7147465_2 PFAM UvrD REP helicase K03656,K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 540.0
TLS2_k127_7147465_20 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000002346 147.0
TLS2_k127_7147465_21 overlaps another CDS with the same product name K11472 - - 0.000000000000000000000000000000007936 146.0
TLS2_k127_7147465_23 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000001161 115.0
TLS2_k127_7147465_24 COGs COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase K05710 - - 0.000000000000000000000000173 110.0
TLS2_k127_7147465_26 acetyltransferase involved in intracellular survival and related - - - 0.00000000000000000002596 104.0
TLS2_k127_7147465_27 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000000003726 66.0
TLS2_k127_7147465_3 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 512.0
TLS2_k127_7147465_4 LytB protein K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 490.0
TLS2_k127_7147465_5 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 480.0
TLS2_k127_7147465_6 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 493.0
TLS2_k127_7147465_7 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 466.0
TLS2_k127_7147465_8 PFAM peptidase M18 aminopeptidase I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009471 425.0
TLS2_k127_7147465_9 4Fe-4S binding domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 401.0
TLS2_k127_7154291_0 Domain of unknown function (DUF3427) - - - 0.0 1373.0
TLS2_k127_7154291_1 RNase_H superfamily - - - 9.83e-322 1020.0
TLS2_k127_7154291_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008825 351.0
TLS2_k127_7154291_11 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 330.0
TLS2_k127_7154291_12 Integrase core domain K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 305.0
TLS2_k127_7154291_13 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000001094 249.0
TLS2_k127_7154291_15 D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000009388 219.0
TLS2_k127_7154291_16 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000003572 219.0
TLS2_k127_7154291_17 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000001782 202.0
TLS2_k127_7154291_18 Lytic transglycosylase catalytic K08307 - - 0.0000000000000000000000000000000000000000000000000000095 205.0
TLS2_k127_7154291_19 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.000000000000000000000000000000000000000000000009527 177.0
TLS2_k127_7154291_2 TonB-dependent receptor - - - 1.904e-276 891.0
TLS2_k127_7154291_20 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000000000000000000001953 154.0
TLS2_k127_7154291_21 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000000000000001292 160.0
TLS2_k127_7154291_22 regulation of single-species biofilm formation K13572,K13573 - - 0.000000000000000000000000000000006591 146.0
TLS2_k127_7154291_23 Protein of unknown function (DUF2442) - - - 0.000000000000000000000000000000009548 132.0
TLS2_k127_7154291_24 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000001576 137.0
TLS2_k127_7154291_25 PFAM transposase IS3 IS911 family protein K07497 - - 0.0000000000000000000000000000002162 124.0
TLS2_k127_7154291_26 Cold shock K03704 - - 0.000000000000000000000000000007927 119.0
TLS2_k127_7154291_27 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000000000001712 113.0
TLS2_k127_7154291_28 nuclear chromosome segregation - - - 0.000000000000000000000000003971 120.0
TLS2_k127_7154291_29 transcriptional regulator K13572,K13573 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000001022 120.0
TLS2_k127_7154291_3 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K01281 - 3.4.14.11 6.439e-260 816.0
TLS2_k127_7154291_30 nUDIX hydrolase K03574,K08320 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55,3.6.1.65 0.0000000000000000000000001301 113.0
TLS2_k127_7154291_31 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000001835 110.0
TLS2_k127_7154291_32 Protein of unknown function (DUF2442) - - - 0.00000000000000000000009907 104.0
TLS2_k127_7154291_33 - - - - 0.00000000000000000001468 94.0
TLS2_k127_7154291_34 ECF sigma factor K03088 - - 0.00000000000000000002587 99.0
TLS2_k127_7154291_35 T5orf172 - - - 0.00000000000000001006 93.0
TLS2_k127_7154291_36 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000205 84.0
TLS2_k127_7154291_37 Domain of unknown function (DUF4974) K07165 - - 0.00000000000000002224 94.0
TLS2_k127_7154291_38 - - - - 0.00000000000000007644 91.0
TLS2_k127_7154291_39 Iron dependent repressor, N-terminal DNA binding domain - - - 0.00000000000002105 76.0
TLS2_k127_7154291_4 N-Acyl-D-aspartate D-glutamate deacylase K01465,K06015 - 3.5.1.81,3.5.2.3 3.982e-223 706.0
TLS2_k127_7154291_42 PFAM Integrase catalytic - - - 0.00000004475 55.0
TLS2_k127_7154291_43 - - - - 0.00002798 48.0
TLS2_k127_7154291_5 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 584.0
TLS2_k127_7154291_6 ParB-like nuclease domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 382.0
TLS2_k127_7154291_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008422 392.0
TLS2_k127_7154291_8 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 374.0
TLS2_k127_7154291_9 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 353.0
TLS2_k127_7213103_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 6.508e-280 872.0
TLS2_k127_7213103_1 TIGRFAM glycogen debranching enzyme - - - 2.804e-230 727.0
TLS2_k127_7213103_10 mismatched DNA binding K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 413.0
TLS2_k127_7213103_11 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 338.0
TLS2_k127_7213103_12 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009428 323.0
TLS2_k127_7213103_13 Prokaryotic glutathione synthetase, N-terminal domain K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 313.0
TLS2_k127_7213103_14 Growth inhibitor K07171 - - 0.0000000000000000000000000000000000000000000001387 179.0
TLS2_k127_7213103_15 Ferredoxin - - - 0.0000000000000000000000000000000000004104 147.0
TLS2_k127_7213103_16 Peptidase M50B-like - - - 0.0000000000000000000000000000000000004387 148.0
TLS2_k127_7213103_17 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000000000006465 115.0
TLS2_k127_7213103_18 Protein of unknown function (DUF3018) - - - 0.000000000000000000003174 94.0
TLS2_k127_7213103_19 TIGRFAM glycogen debranching enzyme - - - 0.00000000000000000001232 95.0
TLS2_k127_7213103_2 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 - 5.4.2.2 1.89e-222 700.0
TLS2_k127_7213103_20 amine dehydrogenase activity - - - 0.00001989 57.0
TLS2_k127_7213103_3 AbgT putative transporter family K12942 - - 1.401e-216 683.0
TLS2_k127_7213103_4 repeat protein - - - 4.464e-215 692.0
TLS2_k127_7213103_5 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 623.0
TLS2_k127_7213103_6 RecQ zinc-binding K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 551.0
TLS2_k127_7213103_7 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 546.0
TLS2_k127_7213103_8 DUF1704 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008367 475.0
TLS2_k127_7213103_9 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 428.0
TLS2_k127_7387316_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009469 367.0
TLS2_k127_7387316_1 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 366.0
TLS2_k127_7387316_10 PFAM Prenyltransferase squalene oxidase K06045 - 4.2.1.129,5.4.99.17 0.00000000000000000000000000000005072 137.0
TLS2_k127_7387316_11 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000007233 134.0
TLS2_k127_7387316_12 amine dehydrogenase activity - - - 0.0000000000000000000000000003029 132.0
TLS2_k127_7387316_13 Peptidase family M50 - - - 0.00000000000000000000000003794 116.0
TLS2_k127_7387316_15 Membrane - - - 0.00000000000003874 81.0
TLS2_k127_7387316_16 Cupin 2, conserved barrel domain protein K18991 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617 - 0.0000000000588 68.0
TLS2_k127_7387316_17 diguanylate cyclase - - - 0.0000000006636 68.0
TLS2_k127_7387316_2 ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 355.0
TLS2_k127_7387316_3 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005114 280.0
TLS2_k127_7387316_4 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006778 274.0
TLS2_k127_7387316_5 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000007659 235.0
TLS2_k127_7387316_6 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000183 221.0
TLS2_k127_7387316_7 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000008639 201.0
TLS2_k127_7387316_8 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000209 212.0
TLS2_k127_7387316_9 COG0671 Membrane-associated phospholipid phosphatase - - - 0.0000000000000000000000000000000000000000000009222 182.0
TLS2_k127_7403645_0 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 0.0 2007.0
TLS2_k127_7403645_1 DbpA RNA binding domain K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 4.136e-233 734.0
TLS2_k127_7403645_10 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 332.0
TLS2_k127_7403645_11 Fe-S cluster K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 304.0
TLS2_k127_7403645_12 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004033 271.0
TLS2_k127_7403645_13 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000000000000000000000000000003064 243.0
TLS2_k127_7403645_14 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000005189 223.0
TLS2_k127_7403645_15 redox protein regulator of disulfide bond formation K04063 - - 0.00000000000000000000000000000000000001067 153.0
TLS2_k127_7403645_16 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000001136 160.0
TLS2_k127_7403645_17 Part of a membrane complex involved in electron transport - - - 0.000000000000000000000000000001178 137.0
TLS2_k127_7403645_18 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000004342 115.0
TLS2_k127_7403645_19 - - - - 0.0000000002355 71.0
TLS2_k127_7403645_2 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 2.931e-227 720.0
TLS2_k127_7403645_3 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007336 508.0
TLS2_k127_7403645_4 Part of a membrane complex involved in electron transport K03615 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 443.0
TLS2_k127_7403645_5 Na H antiporter K03315 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 445.0
TLS2_k127_7403645_6 PFAM Cys Met metabolism K01739,K01760,K01761,K17217 - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 364.0
TLS2_k127_7403645_7 Signal Transduction Histidine Kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 358.0
TLS2_k127_7403645_8 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 353.0
TLS2_k127_7403645_9 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003859 318.0
TLS2_k127_820837_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1159.0
TLS2_k127_820837_1 DNA topoisomerase II activity K02469 - 5.99.1.3 2.767e-321 1004.0
TLS2_k127_820837_10 cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004408 285.0
TLS2_k127_820837_11 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008582 281.0
TLS2_k127_820837_12 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001343 258.0
TLS2_k127_820837_13 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000004754 196.0
TLS2_k127_820837_14 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000002577 178.0
TLS2_k127_820837_15 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000001373 163.0
TLS2_k127_820837_16 COG1651 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000002159 143.0
TLS2_k127_820837_17 PFAM DSBA oxidoreductase - - - 0.0000000000000000000000000002494 124.0
TLS2_k127_820837_18 Vitamin K epoxide reductase family - - - 0.00000000000000000002963 97.0
TLS2_k127_820837_19 Domain of unknown function (DUF4837) - - - 0.0000001249 63.0
TLS2_k127_820837_2 Elongation factor G C-terminus K06207 - - 1.498e-275 861.0
TLS2_k127_820837_20 Protein of unknown function (DUF402) K07586 - - 0.0001961 51.0
TLS2_k127_820837_3 DNA polymerase III alpha subunit K02337,K14162 - 2.7.7.7 9.181e-259 839.0
TLS2_k127_820837_4 Belongs to the enoyl-CoA hydratase isomerase family K01782,K01825 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 565.0
TLS2_k127_820837_5 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 439.0
TLS2_k127_820837_6 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 360.0
TLS2_k127_820837_7 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 357.0
TLS2_k127_820837_8 PSP1 C-terminal conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 313.0
TLS2_k127_820837_9 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 310.0
TLS2_k127_907377_0 WD40-like Beta Propeller Repeat - - - 0.0 1038.0
TLS2_k127_907377_1 Acetyl xylan esterase (AXE1) - - - 4.883e-293 917.0
TLS2_k127_907377_10 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000005034 252.0
TLS2_k127_907377_11 Phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000103 241.0
TLS2_k127_907377_12 RmlD substrate binding domain K00067 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000007313 229.0
TLS2_k127_907377_13 Domain of unknown function (DUF1906) - - - 0.00000000000000000000000000000000000000000000000000000002986 206.0
TLS2_k127_907377_14 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000005384 85.0
TLS2_k127_907377_15 toxin-antitoxin pair type II binding - - - 0.000000000001132 72.0
TLS2_k127_907377_16 Ribosomal protein S21 K02970 - - 0.000000003321 59.0
TLS2_k127_907377_17 Plasmid stabilization system K19092 - - 0.00000003487 59.0
TLS2_k127_907377_18 23S rRNA-intervening sequence protein - - - 0.000001114 55.0
TLS2_k127_907377_2 Sodium:alanine symporter family K03310 - - 1.311e-214 682.0
TLS2_k127_907377_3 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 599.0
TLS2_k127_907377_4 Mur ligase middle domain K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 419.0
TLS2_k127_907377_5 ATPase activity K06027 - 3.6.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 395.0
TLS2_k127_907377_6 PAS domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 377.0
TLS2_k127_907377_7 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008637 303.0
TLS2_k127_907377_8 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004307 294.0
TLS2_k127_907377_9 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003519 289.0
TLS2_k127_939093_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 471.0
TLS2_k127_939093_1 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 336.0
TLS2_k127_939093_2 Cysteine-rich CPXCG - - - 0.000000000000000000000003333 103.0
TLS2_k127_945427_0 Peptidase family M49 - - - 2.911e-221 698.0
TLS2_k127_945427_1 Transporter K12942 - - 4.272e-216 683.0
TLS2_k127_945427_10 Mitochondrial degradasome RNA helicase subunit C terminal K17675 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 409.0
TLS2_k127_945427_11 Nitronate monooxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 384.0
TLS2_k127_945427_12 Mate efflux family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006612 362.0
TLS2_k127_945427_13 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 334.0
TLS2_k127_945427_14 thiolester hydrolase activity K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007017 338.0
TLS2_k127_945427_15 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 299.0
TLS2_k127_945427_16 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002917 275.0
TLS2_k127_945427_17 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000662 271.0
TLS2_k127_945427_18 PFAM RES domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002088 257.0
TLS2_k127_945427_19 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000084 258.0
TLS2_k127_945427_2 Na+/H+ antiporter family - - - 2.503e-204 647.0
TLS2_k127_945427_20 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000004617 247.0
TLS2_k127_945427_21 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000001983 205.0
TLS2_k127_945427_22 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000003777 195.0
TLS2_k127_945427_23 EVE domain - - - 0.00000000000000000000000000000000000000000000000002947 185.0
TLS2_k127_945427_24 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000001856 175.0
TLS2_k127_945427_25 Tetratricopeptide repeat K08309 - - 0.00000000000000000000000000000000000000000000493 181.0
TLS2_k127_945427_26 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000002839 162.0
TLS2_k127_945427_27 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000007337 159.0
TLS2_k127_945427_28 - - - - 0.000000000000000000000000000000000000000002541 171.0
TLS2_k127_945427_3 MatE - - - 4.276e-198 630.0
TLS2_k127_945427_30 Putative heavy-metal-binding - - - 0.0000000000000000000000000000000000002706 143.0
TLS2_k127_945427_31 - - - - 0.000000000000000000000000000000000004057 152.0
TLS2_k127_945427_32 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000001019 138.0
TLS2_k127_945427_33 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000002968 139.0
TLS2_k127_945427_34 Domain of unknown function (DUF3817) - - - 0.00000000000000000000000000003313 121.0
TLS2_k127_945427_35 ECF sigma factor K03088 - - 0.00000000000000000000000004901 114.0
TLS2_k127_945427_36 Winged helix DNA-binding domain - - - 0.0000000000000000000002317 105.0
TLS2_k127_945427_37 CAAX protease self-immunity - - - 0.0000005002 62.0
TLS2_k127_945427_38 - - - - 0.00002322 55.0
TLS2_k127_945427_39 PFAM blue (type 1) copper domain protein - - - 0.00008896 51.0
TLS2_k127_945427_4 Ferric reductase like transmembrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 612.0
TLS2_k127_945427_40 Putative zinc-finger - - - 0.0002915 50.0
TLS2_k127_945427_5 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 540.0
TLS2_k127_945427_6 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 497.0
TLS2_k127_945427_7 beta-N-acetylglucosaminidase K01197 - 3.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 484.0
TLS2_k127_945427_8 Outer membrane protein beta-barrel family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 425.0
TLS2_k127_945427_9 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008195 384.0
TLS2_k127_998280_0 ABC transporter transmembrane region K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003897 608.0
TLS2_k127_998280_1 Mo-molybdopterin cofactor metabolic process K03148,K03636,K21029,K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 534.0
TLS2_k127_998280_10 DNA methyltransferase K07318 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000216 219.0
TLS2_k127_998280_11 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000006676 196.0
TLS2_k127_998280_12 EAL domain - - - 0.00000000000000000000000000000000000000000000000000044 206.0
TLS2_k127_998280_13 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000001066 198.0
TLS2_k127_998280_14 Histidine biosynthesis bifunctional protein hisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000003382 166.0
TLS2_k127_998280_15 Cell wall-active antibiotics response 4TMS YvqF - - - 0.00000000000000000000000000000000000001441 154.0
TLS2_k127_998280_16 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000004129 128.0
TLS2_k127_998280_17 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000003485 116.0
TLS2_k127_998280_18 membrane - - - 0.00000000000000000000000017 111.0
TLS2_k127_998280_19 JAB1/Mov34/MPN/PAD-1 ubiquitin protease - - - 0.0000000000000002013 85.0
TLS2_k127_998280_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 336.0
TLS2_k127_998280_20 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000007374 64.0
TLS2_k127_998280_3 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 336.0
TLS2_k127_998280_4 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 306.0
TLS2_k127_998280_5 EAL domain K13950,K21025 - 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005883 299.0
TLS2_k127_998280_6 PFAM inositol monophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004606 281.0
TLS2_k127_998280_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005832 265.0
TLS2_k127_998280_8 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000001231 224.0
TLS2_k127_998280_9 Histidine biosynthesis protein K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000003928 228.0
TLS2_k127_999471_0 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 361.0
TLS2_k127_999471_1 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002816 241.0
TLS2_k127_999471_2 PaaX-like protein K02616 - - 0.000000000000000000000000000000000000000000000000000000000000000006225 235.0
TLS2_k127_999471_3 Domain of unknown function (DUF4112) - - - 0.0000000000000000000000000000000000009432 144.0
TLS2_k127_999471_4 MaoC like domain - - - 0.000000000000000000000000001407 118.0
TLS2_k127_999471_5 Transglycosylase associated protein - - - 0.000000000000000000001118 98.0