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Overview

ID MAG04016
Name TLS2_bin.56
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Thermoleophilia
Order Solirubrobacterales
Family 70-9
Genus DATHVI01
Species
Assembly information
Completeness (%) 65.76
Contamination (%) 0.9
GC content (%) 73.0
N50 (bp) 7,850
Genome size (bp) 1,592,480

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1543

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1015670_0 DAHP synthetase I family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 503.0
TLS2_k127_1015670_1 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000004113 273.0
TLS2_k127_1015670_2 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000001407 251.0
TLS2_k127_1015670_3 May catalyze the transamination reaction in phenylalanine biosynthesis K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000006419 263.0
TLS2_k127_1015670_4 Segregation and condensation complex subunit ScpB K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000006614 233.0
TLS2_k127_1015670_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000009599 229.0
TLS2_k127_1015670_6 Chorismate mutase type I K06208 - 5.4.99.5 0.000000000000000000000000000000000000000000009269 165.0
TLS2_k127_1025582_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.395e-237 747.0
TLS2_k127_1025582_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 453.0
TLS2_k127_1025582_10 RF-1 domain K15034 - - 0.0000000000000000000000000000008648 131.0
TLS2_k127_1025582_11 'glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.000000000000000000000000341 113.0
TLS2_k127_1025582_2 Bacterial phospho-glucose isomerase C-terminal SIS domain K15916 - 5.3.1.8,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 365.0
TLS2_k127_1025582_3 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006137 347.0
TLS2_k127_1025582_4 Cellulose biosynthesis protein BcsQ - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 332.0
TLS2_k127_1025582_5 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 323.0
TLS2_k127_1025582_6 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 316.0
TLS2_k127_1025582_7 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 300.0
TLS2_k127_1025582_8 Redoxin - - - 0.00000000000000000000000000000000000000000000001799 181.0
TLS2_k127_1025582_9 Conserved Protein - - - 0.00000000000000000000000000000000339 139.0
TLS2_k127_1060449_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008414 509.0
TLS2_k127_1060449_1 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 338.0
TLS2_k127_1060449_2 Peptidase family M23 - - - 0.00000000000000000000000000000000000000786 156.0
TLS2_k127_1084334_0 MASE1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000296 284.0
TLS2_k127_1084334_1 PAS fold - - - 0.000000001477 70.0
TLS2_k127_1084334_2 Belongs to the anti-sigma-factor antagonist family K06378 - - 0.0000001115 64.0
TLS2_k127_1151889_0 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008588 398.0
TLS2_k127_1151889_1 IMP dehydrogenase GMP reductase K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 316.0
TLS2_k127_1151889_2 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000002455 278.0
TLS2_k127_1151889_3 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.00000000000000000000000000000000000001158 151.0
TLS2_k127_115358_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 1.12e-285 903.0
TLS2_k127_115358_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000005601 160.0
TLS2_k127_115358_2 competence protein - - - 0.000000000000000008775 96.0
TLS2_k127_1177952_0 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002356 243.0
TLS2_k127_1177952_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000001564 202.0
TLS2_k127_1177952_2 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000000000000000001087 174.0
TLS2_k127_1177952_3 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000000000003277 139.0
TLS2_k127_1177952_4 methyltransferase - - - 0.0000000000000000000000000000000004852 139.0
TLS2_k127_1177952_5 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000004949 127.0
TLS2_k127_1177952_6 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000001115 86.0
TLS2_k127_1177981_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000815 614.0
TLS2_k127_1177981_1 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000856 133.0
TLS2_k127_1177981_2 Dak1_2 K07030 - - 0.00000000000006329 73.0
TLS2_k127_1179063_0 COG0530 Ca2 Na antiporter - - - 0.0000000000000000000000000000000000000000000000001204 186.0
TLS2_k127_1179063_1 - - - - 0.000000000000001779 89.0
TLS2_k127_1181864_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 555.0
TLS2_k127_1181864_1 alpha beta alpha domain I K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007551 558.0
TLS2_k127_1181864_2 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 357.0
TLS2_k127_1181864_3 Histidine triad (HIT) protein K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000000000001583 201.0
TLS2_k127_1181864_4 Histidine triad (Hit) protein K02503 - - 0.0000000000000000000000000000000000000000000008478 171.0
TLS2_k127_1181864_5 - - - - 0.0000000000000000000000006202 114.0
TLS2_k127_1181864_6 Glycosyltransferase like family 2 - - - 0.0000000000000000001161 100.0
TLS2_k127_1181864_7 alpha beta alpha domain I K01840 - 5.4.2.8 0.0000000000000001272 79.0
TLS2_k127_1181864_8 Thrombospondin type 3 repeat - - - 0.0000000000741 73.0
TLS2_k127_1181864_9 Alpha beta hydrolase - - - 0.0000008334 55.0
TLS2_k127_1223252_0 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000005286 217.0
TLS2_k127_1223252_1 Molybdenum ABC transporter K02020 - - 0.00000000000000000000000000000000000000000000000000000000001677 216.0
TLS2_k127_1223252_2 pfam abc K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000007517 175.0
TLS2_k127_1223252_3 Transcriptional Regulator of molybdate metabolism, XRE family - - - 0.0000000000000000000000003599 117.0
TLS2_k127_1226198_0 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 592.0
TLS2_k127_1226198_1 endonuclease III K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000001563 196.0
TLS2_k127_1244683_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 616.0
TLS2_k127_1244683_1 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000002963 222.0
TLS2_k127_1244683_2 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000008837 209.0
TLS2_k127_1244683_4 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000008393 117.0
TLS2_k127_1244683_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000003831 67.0
TLS2_k127_1244683_6 Septum formation initiator - - - 0.0000007763 58.0
TLS2_k127_1251726_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1313.0
TLS2_k127_1251726_1 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 503.0
TLS2_k127_1251726_2 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001412 291.0
TLS2_k127_1251726_3 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005238 252.0
TLS2_k127_1251726_4 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000004549 236.0
TLS2_k127_1251726_5 O-Antigen ligase - - - 0.000000000000000000000000000000000000003686 167.0
TLS2_k127_1251726_6 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000004613 123.0
TLS2_k127_1251726_7 helix_turn_helix, Lux Regulon - - - 0.000000000008718 71.0
TLS2_k127_1251726_8 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0002722 51.0
TLS2_k127_1274330_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1380.0
TLS2_k127_1274330_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.633e-259 815.0
TLS2_k127_1274330_2 Subtilase family K14645 GO:0005575,GO:0005576 - 0.000000000000000000000000000000000000000000000000001884 209.0
TLS2_k127_1274330_3 Sugar (and other) transporter - - - 0.000000000000000000000000000000000009045 141.0
TLS2_k127_1274330_4 Zn peptidase - - - 0.000000000000000002448 98.0
TLS2_k127_1274330_5 Belongs to the peptidase S8 family - - - 0.0000005883 63.0
TLS2_k127_1327070_0 ATPases associated with a variety of cellular activities K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 331.0
TLS2_k127_1327070_1 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000002602 273.0
TLS2_k127_1327070_2 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000001144 245.0
TLS2_k127_1327070_3 RNB K12573 - - 0.00000000000000000000000002234 125.0
TLS2_k127_1328000_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.571e-234 733.0
TLS2_k127_1328000_1 Peptidase dimerisation domain K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 430.0
TLS2_k127_1328000_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 357.0
TLS2_k127_1328000_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000002905 201.0
TLS2_k127_1328000_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000002736 136.0
TLS2_k127_1336963_0 Pyridoxal-phosphate dependent enzyme K12339,K21148 - 2.5.1.113,2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 451.0
TLS2_k127_1336963_2 JAB/MPN domain K21140 - 3.13.1.6 0.00000000000000000000000000000001187 130.0
TLS2_k127_1336963_3 - - - - 0.00000000000000000000000000005459 123.0
TLS2_k127_1336963_4 Iron-sulfur cluster loop - - - 0.00000000000000000000003723 115.0
TLS2_k127_1344815_0 Daunorubicin resistance ABC transporter ATP-binding subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 505.0
TLS2_k127_1344815_1 Transport permease protein K01992,K18233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000012 275.0
TLS2_k127_1344815_2 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000003856 258.0
TLS2_k127_1344815_3 Transport permease protein K01992,K18233 - - 0.000000000000000000000000000103 130.0
TLS2_k127_1344815_4 - - - - 0.0000000000000000000005242 99.0
TLS2_k127_1358611_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 487.0
TLS2_k127_1358611_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 458.0
TLS2_k127_1358611_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 297.0
TLS2_k127_1358611_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000003078 184.0
TLS2_k127_1358611_4 POTRA domain, FtsQ-type K03589 - - 0.0000000000000000000000000000000007607 139.0
TLS2_k127_1370136_0 Elongator protein 3 MiaB NifB K11779 - 2.5.1.77 0.0 1056.0
TLS2_k127_1370136_1 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 463.0
TLS2_k127_1370136_2 HMGL-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 421.0
TLS2_k127_1370136_3 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 371.0
TLS2_k127_1370136_4 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000001726 259.0
TLS2_k127_1370136_5 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000178 246.0
TLS2_k127_1370136_6 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000813 223.0
TLS2_k127_1370136_7 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000000000000001248 182.0
TLS2_k127_1370136_8 Psort location Cytoplasmic, score - - - 0.0000000002645 68.0
TLS2_k127_1376275_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 3.224e-249 787.0
TLS2_k127_1376275_1 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 516.0
TLS2_k127_1376275_2 Dehydrogenase E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 414.0
TLS2_k127_1376275_4 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.0000000000000000000000000000003769 129.0
TLS2_k127_1376275_5 diguanylate cyclase - - - 0.00000000000001072 83.0
TLS2_k127_1376275_7 antisigma factor binding K04749 - - 0.00000000000738 72.0
TLS2_k127_1376275_8 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000001008 68.0
TLS2_k127_1376275_9 - - - - 0.0005626 51.0
TLS2_k127_1388748_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 420.0
TLS2_k127_1388748_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 305.0
TLS2_k127_1388748_2 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000042 135.0
TLS2_k127_1388748_3 guanyl-nucleotide exchange factor activity - - - 0.000000000000000000007794 106.0
TLS2_k127_1388748_4 Thrombospondin type 3 repeat - - - 0.000000000000006033 85.0
TLS2_k127_1388748_5 Thrombospondin type 3 repeat - - - 0.000000003401 69.0
TLS2_k127_1427898_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 585.0
TLS2_k127_1427898_1 Divalent cation transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 434.0
TLS2_k127_1427898_2 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000801 394.0
TLS2_k127_1427898_3 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 344.0
TLS2_k127_1427898_4 Nucleotidyl transferase K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 310.0
TLS2_k127_1427898_5 Alpha/beta hydrolase family K01563 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000006452 218.0
TLS2_k127_1427898_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000001239 207.0
TLS2_k127_1427898_7 ThiS family K03636 - - 0.0000000000000000000000000000759 122.0
TLS2_k127_1427898_8 Alpha/beta hydrolase family - - - 0.0000000001013 64.0
TLS2_k127_1497037_0 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005284 277.0
TLS2_k127_1497037_1 response regulator, receiver K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005333 256.0
TLS2_k127_1497037_2 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000505 61.0
TLS2_k127_1503163_0 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain K01596 - 4.1.1.32 3.29e-259 806.0
TLS2_k127_1503163_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K15232 - 6.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 549.0
TLS2_k127_1503163_2 Succinyl-CoA ligase like flavodoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 455.0
TLS2_k127_1586559_0 Belongs to the GcvT family K06980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005768 263.0
TLS2_k127_1586559_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001442 268.0
TLS2_k127_1586559_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000008125 203.0
TLS2_k127_1586559_3 NMT1/THI5 like K02051 - - 0.00000000000000000000000000000000000000000000000000000144 211.0
TLS2_k127_1586559_4 Belongs to the MIP aquaporin (TC 1.A.8) family K02440,K06188,K09874 - - 0.000000000000000000000000000000000000000000000341 176.0
TLS2_k127_1586559_5 - - - - 0.0000000000000000000000000000000000000000003425 161.0
TLS2_k127_1586559_6 HD domain - - - 0.0000000000000000000000003415 123.0
TLS2_k127_1607679_0 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 580.0
TLS2_k127_1607679_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 389.0
TLS2_k127_1607679_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 360.0
TLS2_k127_1607679_3 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000009312 249.0
TLS2_k127_1607679_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000009927 228.0
TLS2_k127_1607679_5 - - - - 0.000000000000000000000000000000000000000001739 159.0
TLS2_k127_1607679_6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000004425 112.0
TLS2_k127_165349_0 CoA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004054 629.0
TLS2_k127_165349_1 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 367.0
TLS2_k127_165349_2 Bacitracin resistance protein BacA K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000007587 249.0
TLS2_k127_165349_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000001031 223.0
TLS2_k127_1656798_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 2.738e-261 814.0
TLS2_k127_1656798_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 400.0
TLS2_k127_1656798_2 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008625 345.0
TLS2_k127_1656798_3 Cysteine-rich domain K00241 - - 0.0000000000000000000000000000000009015 131.0
TLS2_k127_1656798_4 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000008208 144.0
TLS2_k127_1656798_5 Peptidase family M28 - - - 0.0000000000001699 84.0
TLS2_k127_1677127_0 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 447.0
TLS2_k127_1677127_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 443.0
TLS2_k127_1681381_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002025 248.0
TLS2_k127_1681381_1 transcriptional regulator - - - 0.000000000000000000000000000000000000000000003555 170.0
TLS2_k127_1681381_2 Predicted integral membrane protein (DUF2269) - - - 0.000000000000000000000000007287 124.0
TLS2_k127_1681381_3 Belongs to the aldehyde dehydrogenase family K00146 - 1.2.1.39 0.0000000000000004786 78.0
TLS2_k127_1722822_0 dna ligase K01971 - 6.5.1.1 6.219e-194 639.0
TLS2_k127_1722822_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 488.0
TLS2_k127_1722822_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 301.0
TLS2_k127_1722822_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000004745 161.0
TLS2_k127_1722822_4 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000001782 151.0
TLS2_k127_1722822_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000003137 130.0
TLS2_k127_1722822_6 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000001742 115.0
TLS2_k127_1722822_7 TIGRFAM competence protein ComEA helix-hairpin-helix repeat K02237 - - 0.00006939 52.0
TLS2_k127_1768518_0 Ftsk_gamma K03466 - - 3.095e-228 731.0
TLS2_k127_1768518_1 Helix-turn-helix domain - - - 0.0000000000000000005188 92.0
TLS2_k127_1806176_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.106e-208 661.0
TLS2_k127_1806176_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 582.0
TLS2_k127_1806176_2 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007409 513.0
TLS2_k127_1806176_3 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 366.0
TLS2_k127_1806176_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000003048 120.0
TLS2_k127_1806176_5 - - - - 0.000000000000000000004544 95.0
TLS2_k127_1806176_6 Zincin-like metallopeptidase - - - 0.000000006383 68.0
TLS2_k127_1829713_0 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 346.0
TLS2_k127_1829713_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002982 278.0
TLS2_k127_1829713_2 O-Antigen ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000024 229.0
TLS2_k127_1830634_0 DNA methylase K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004789 309.0
TLS2_k127_1830634_1 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000001431 226.0
TLS2_k127_1830634_2 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000007277 188.0
TLS2_k127_1830634_3 - - - - 0.00000000000000000002094 97.0
TLS2_k127_1857844_0 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 403.0
TLS2_k127_1857844_1 FeoA K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002085 283.0
TLS2_k127_1857844_2 Zinc-uptake complex component A periplasmic K02077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000149 271.0
TLS2_k127_1857844_3 ATPases associated with a variety of cellular activities K11710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009088 267.0
TLS2_k127_1857844_4 ABC 3 transport family - - - 0.00000000000000000000000000000000000000000000000000000000000004574 236.0
TLS2_k127_1857844_5 ABC 3 transport family - - - 0.00000000000000000000000000000000000000000000000000000001196 208.0
TLS2_k127_1857844_6 Ferric uptake regulator family K03711 - - 0.00000000000000000000000000000000000000000007418 165.0
TLS2_k127_1857844_7 Thioredoxin - - - 0.00000000000000000000000000000007685 133.0
TLS2_k127_1857844_9 Peptidase, M23 - - - 0.000000000000004629 87.0
TLS2_k127_186546_0 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 575.0
TLS2_k127_186546_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006819 396.0
TLS2_k127_186546_2 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000000000000000000000000000000000000000000000000002822 227.0
TLS2_k127_186546_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000003434 171.0
TLS2_k127_1911864_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.289e-222 701.0
TLS2_k127_1911864_1 abc transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 317.0
TLS2_k127_1911864_2 - - - - 0.0000007077 60.0
TLS2_k127_1923707_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 603.0
TLS2_k127_1923707_1 MlaD protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 427.0
TLS2_k127_1923707_2 MlaD protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 374.0
TLS2_k127_1923707_3 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000365 198.0
TLS2_k127_1923707_4 MlaD protein - - - 0.000000001723 62.0
TLS2_k127_1937457_0 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 437.0
TLS2_k127_1937457_1 ATPase (P-type) K01537,K12952 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005581 366.0
TLS2_k127_1937457_2 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000004093 275.0
TLS2_k127_1937457_3 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000003382 256.0
TLS2_k127_1937457_4 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004876 247.0
TLS2_k127_1937457_5 transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001003 262.0
TLS2_k127_1937457_6 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000002091 250.0
TLS2_k127_1937457_7 conserved protein (DUF2267) - - - 0.0000000000000000000000000000000003945 137.0
TLS2_k127_2010097_0 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 511.0
TLS2_k127_2010097_1 LexA DNA binding domain K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000008919 237.0
TLS2_k127_2018128_0 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002342 317.0
TLS2_k127_2018128_1 Thioredoxin K05838 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002454 267.0
TLS2_k127_2018128_2 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000003288 205.0
TLS2_k127_2018128_3 Uncharacterized ACR, COG1678 K07735 - - 0.00000000000000000000000000000000000000000000000000002909 196.0
TLS2_k127_2018128_4 Lytic transglycolase - - - 0.00000000000000000000000000000000008228 146.0
TLS2_k127_2109943_0 YceI-like domain - - - 0.000000000000000000000000000000000000000000001022 175.0
TLS2_k127_2109943_1 PFAM regulatory protein, MarR - - - 0.0000000000000000000000000006997 120.0
TLS2_k127_2109943_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000001243 117.0
TLS2_k127_2109943_3 Protein of unknown function (DUF1211) - - - 0.000000000000004405 83.0
TLS2_k127_2137639_0 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 492.0
TLS2_k127_2137639_1 YCII-related domain - - - 0.0000000000000000000000002948 110.0
TLS2_k127_2137639_2 YCII-related domain - - - 0.0000000000000000002023 93.0
TLS2_k127_2137639_3 Sulfotransferase family - - - 0.0000000000003659 79.0
TLS2_k127_2164842_0 Belongs to the SEDS family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 493.0
TLS2_k127_2164842_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 469.0
TLS2_k127_2164842_2 Penicillin binding protein transpeptidase domain K05364 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 390.0
TLS2_k127_2164842_3 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 339.0
TLS2_k127_2164842_4 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 340.0
TLS2_k127_2164842_5 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 308.0
TLS2_k127_2164842_6 Protein of unknown function (DUF2662) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006566 272.0
TLS2_k127_2164842_7 Forkhead associated domain - - - 0.00000000000000000000000002479 116.0
TLS2_k127_2164842_8 Protein tyrosine kinase - - - 0.0001466 52.0
TLS2_k127_2173456_0 Heavy metal translocating P-type atpase K01533,K17686 - 3.6.3.4,3.6.3.54 1.89e-299 932.0
TLS2_k127_2173456_1 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 560.0
TLS2_k127_2173456_10 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000252 266.0
TLS2_k127_2173456_11 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000000008937 257.0
TLS2_k127_2173456_12 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000005629 237.0
TLS2_k127_2173456_13 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.0000000000000000000000000000000000000000000000000001216 195.0
TLS2_k127_2173456_14 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.00000008022 65.0
TLS2_k127_2173456_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 542.0
TLS2_k127_2173456_3 6-phosphogluconate dehydrogenase (Decarboxylating) K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 485.0
TLS2_k127_2173456_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000602 351.0
TLS2_k127_2173456_5 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 362.0
TLS2_k127_2173456_6 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 322.0
TLS2_k127_2173456_7 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001197 293.0
TLS2_k127_2173456_8 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006764 272.0
TLS2_k127_2173456_9 Belongs to the TrpC family K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000001859 276.0
TLS2_k127_2184097_0 ABC transporter transmembrane region K06147 - - 3.27e-231 729.0
TLS2_k127_2184097_1 ABC transporter transmembrane region K06147 - - 5.574e-215 712.0
TLS2_k127_2184097_2 EamA-like transporter family K11939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003488 274.0
TLS2_k127_2184097_3 integral membrane protein - - - 0.000000000000000002877 88.0
TLS2_k127_2184097_4 - - - - 0.0000001756 64.0
TLS2_k127_2213237_0 Sulfotransferase domain - - - 0.00000000000000000000000000000000000000000000000000001124 202.0
TLS2_k127_2213237_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000003624 77.0
TLS2_k127_2221727_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008218 522.0
TLS2_k127_2221727_1 NADP transhydrogenase K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 382.0
TLS2_k127_2221727_2 PFAM Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 342.0
TLS2_k127_2221727_3 NADP transhydrogenase K00324 - 1.6.1.2 0.0000000000000000000001596 112.0
TLS2_k127_2221727_4 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000003705 88.0
TLS2_k127_2259093_0 MMPL family K06994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 594.0
TLS2_k127_2259093_1 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 443.0
TLS2_k127_2259093_2 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 422.0
TLS2_k127_2259093_3 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008901 300.0
TLS2_k127_2259093_4 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000000000004735 141.0
TLS2_k127_2259093_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000006663 83.0
TLS2_k127_2259093_7 - - - - 0.0000001062 55.0
TLS2_k127_2294565_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 531.0
TLS2_k127_2294565_1 AAA domain K01935 - 6.3.3.3 0.000000000000000000000000000000000000000001451 159.0
TLS2_k127_2300108_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 567.0
TLS2_k127_2300108_1 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 541.0
TLS2_k127_2300108_2 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 405.0
TLS2_k127_2300108_3 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003562 382.0
TLS2_k127_2300108_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 301.0
TLS2_k127_2300108_5 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000001363 162.0
TLS2_k127_2300108_6 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000009488 122.0
TLS2_k127_2300108_7 COG2346, Truncated hemoglobins K03406,K06886 GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057 - 0.0000000000000000000000001156 115.0
TLS2_k127_2300108_8 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.00001927 57.0
TLS2_k127_2301373_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1095.0
TLS2_k127_2301373_1 Heat shock 70 kDa protein K04043 - - 1.197e-285 885.0
TLS2_k127_2301373_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007907 401.0
TLS2_k127_2301373_3 Domain of unknown function (DUF4142) - - - 0.000000000000000000000000000000000000002818 153.0
TLS2_k127_2301373_4 MerR HTH family regulatory protein K13640 - - 0.00000000000000000000000000000000000009893 147.0
TLS2_k127_2301373_5 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000001137 141.0
TLS2_k127_2301373_6 domain, Protein - - - 0.000000000000000000000000000009897 136.0
TLS2_k127_2301373_7 Short C-terminal domain - - - 0.0000000007506 65.0
TLS2_k127_2311632_0 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 549.0
TLS2_k127_2311632_1 COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474,K10854 - 3.5.2.14,6.4.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 496.0
TLS2_k127_2311632_2 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 362.0
TLS2_k127_2311632_3 Belongs to the glutamine synthetase family K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 344.0
TLS2_k127_2311632_4 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003159 257.0
TLS2_k127_2311632_5 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000007032 181.0
TLS2_k127_2311632_6 Peptidase C26 K01658,K07010 - 4.1.3.27 0.000000000000000000000000000000000000000000001011 177.0
TLS2_k127_2311632_7 PFAM thioesterase superfamily K18014 - 4.3.1.14 0.000000000000000000000000000000000000000103 156.0
TLS2_k127_2311632_8 Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000005278 143.0
TLS2_k127_2311632_9 Acetone carboxylase K10856 - 6.4.1.6 0.00000000000000000000000000000008961 130.0
TLS2_k127_2323630_0 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 359.0
TLS2_k127_2323630_1 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006495 273.0
TLS2_k127_2323630_2 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000003917 186.0
TLS2_k127_2337974_0 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 414.0
TLS2_k127_2337974_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 327.0
TLS2_k127_2337974_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000002656 206.0
TLS2_k127_2337974_3 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000002858 164.0
TLS2_k127_2337974_4 SNARE associated Golgi protein K03975,K19302 - 3.6.1.27 0.000000000000002171 89.0
TLS2_k127_2369140_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 9.14e-231 728.0
TLS2_k127_2369140_1 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 348.0
TLS2_k127_2384836_0 PFAM AMP-dependent synthetase and ligase K01907 - 6.2.1.16 1.106e-296 924.0
TLS2_k127_2384836_1 endonuclease activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000003209 240.0
TLS2_k127_2384836_2 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000193 198.0
TLS2_k127_2384836_6 Cysteine-rich secretory protein family - - - 0.0002007 52.0
TLS2_k127_2440397_0 PFAM ABC transporter related K10441 - 3.6.3.17 1.689e-212 675.0
TLS2_k127_2440397_1 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 9.094e-211 663.0
TLS2_k127_2440397_2 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 556.0
TLS2_k127_2440397_3 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009978 493.0
TLS2_k127_2440397_4 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 460.0
TLS2_k127_2440397_5 TatD related DNase K07051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 424.0
TLS2_k127_2440397_6 Xylose isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 422.0
TLS2_k127_2440397_7 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004606 281.0
TLS2_k127_2440397_8 Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000008131 144.0
TLS2_k127_2462830_0 Peptidase family M41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 568.0
TLS2_k127_2462830_1 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000001923 199.0
TLS2_k127_2462830_2 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000006298 140.0
TLS2_k127_2462830_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000005315 138.0
TLS2_k127_2462830_4 PFAM phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.00000000000000000000000000007429 127.0
TLS2_k127_2462830_5 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000008985 116.0
TLS2_k127_2483486_0 Found in ATP-dependent protease La (LON) K01338 - 3.4.21.53 0.0 1078.0
TLS2_k127_2483486_1 PFAM NADH Ubiquinone plastoquinone (complex I) K05565 - - 1.489e-242 771.0
TLS2_k127_2483486_10 Na H antiporter subunit K05571 - - 0.00000000000000000000000005665 117.0
TLS2_k127_2483486_11 antiporter activity K05563,K05570 - - 0.000000000000000000009614 101.0
TLS2_k127_2483486_12 Metallo-beta-lactamase superfamily - - - 0.00000000000000005321 91.0
TLS2_k127_2483486_2 NADH ubiquinone plastoquinone K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 542.0
TLS2_k127_2483486_3 Ribonucleotide reductase, small chain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 398.0
TLS2_k127_2483486_4 NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 310.0
TLS2_k127_2483486_5 Cation antiporter K05569 - - 0.00000000000000000000000000000000000000001357 160.0
TLS2_k127_2483486_6 - - - - 0.000000000000000000000000000000000004556 142.0
TLS2_k127_2483486_7 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000000000000158 141.0
TLS2_k127_2483486_8 Na H antiporter MnhB subunit-related protein K05566 - - 0.0000000000000000000000000000000002376 154.0
TLS2_k127_2483486_9 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.0000000000000000000000000000001206 136.0
TLS2_k127_2522456_0 iron ion homeostasis K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 374.0
TLS2_k127_2522456_1 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006209 266.0
TLS2_k127_2525172_0 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K10441 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 548.0
TLS2_k127_2525172_1 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 400.0
TLS2_k127_2525172_10 - - - - 0.000000000009104 74.0
TLS2_k127_2525172_11 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000104 70.0
TLS2_k127_2525172_2 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 356.0
TLS2_k127_2525172_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778,K18347 - 1.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 321.0
TLS2_k127_2525172_4 Belongs to the binding-protein-dependent transport system permease family K02057,K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 332.0
TLS2_k127_2525172_5 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000005833 252.0
TLS2_k127_2525172_6 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000006353 243.0
TLS2_k127_2525172_7 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000006966 172.0
TLS2_k127_2525172_8 Domain of unknown function (DUF4430) - - - 0.00000000000000000000000000000000000000003905 166.0
TLS2_k127_2525172_9 sugar isomerase K00820 - 2.6.1.16 0.000000000000000000000000000000000000007429 166.0
TLS2_k127_253177_0 Phospholipase D Active site motif K01115 - 3.1.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 505.0
TLS2_k127_253177_1 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008381 466.0
TLS2_k127_253177_2 CHASE2 K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 383.0
TLS2_k127_253177_3 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00058 - 1.1.1.26,1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009808 340.0
TLS2_k127_253177_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001202 291.0
TLS2_k127_253177_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000116 248.0
TLS2_k127_253177_6 Diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001052 233.0
TLS2_k127_253177_7 PFAM Phosphoglycerate mutase K08296 - - 0.00000000000000000000000000000000000001498 150.0
TLS2_k127_253177_8 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000001668 128.0
TLS2_k127_253177_9 antibiotic catabolic process - - - 0.000000001389 68.0
TLS2_k127_2557365_0 Peptidase M20 K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007798 391.0
TLS2_k127_2557365_1 COGs COG3367 conserved K16149 - 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000009328 277.0
TLS2_k127_2557365_2 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001226 246.0
TLS2_k127_2557365_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001926 245.0
TLS2_k127_2557365_4 Nodulation protein S (NodS) - - - 0.000000000000000000000000000000000000000000000000000001537 199.0
TLS2_k127_2557365_5 Legume lectin domain - - - 0.000000000000009274 84.0
TLS2_k127_2562607_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 8.473e-239 748.0
TLS2_k127_2562607_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 530.0
TLS2_k127_2562607_2 haemagglutination activity domain - - - 0.00009176 48.0
TLS2_k127_2655592_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 444.0
TLS2_k127_2655592_1 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000002573 136.0
TLS2_k127_2659951_0 Two component transcriptional regulator, winged helix family K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000007343 238.0
TLS2_k127_2659951_1 Chaperonin 10 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000002367 197.0
TLS2_k127_2659951_2 PFAM ATP-binding region, ATPase domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000002404 197.0
TLS2_k127_2659951_3 Glycosyl transferase family group 2 K07011 - - 0.000000000237 66.0
TLS2_k127_2659951_4 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0001944 45.0
TLS2_k127_2703136_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 533.0
TLS2_k127_2703136_1 Domain of unknown function (DUF1727) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 527.0
TLS2_k127_2703136_10 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.00000000000000000000000000000000000000004847 164.0
TLS2_k127_2703136_11 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000006084 142.0
TLS2_k127_2703136_12 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000001352 83.0
TLS2_k127_2703136_2 CobB/CobQ-like glutamine amidotransferase domain K07009 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005001 347.0
TLS2_k127_2703136_3 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 287.0
TLS2_k127_2703136_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001706 246.0
TLS2_k127_2703136_5 Belongs to the sigma-70 factor family K03090 GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000009783 208.0
TLS2_k127_2703136_6 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - - 0.0000000000000000000000000000000000000000000000000000003681 200.0
TLS2_k127_2703136_7 Membrane - - - 0.0000000000000000000000000000000000000000000000008602 183.0
TLS2_k127_2703136_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000009224 180.0
TLS2_k127_2703136_9 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000005109 178.0
TLS2_k127_2720033_0 Glutamate synthase central domain K00265 - 1.4.1.13,1.4.1.14 4.192e-309 976.0
TLS2_k127_2720033_1 Colicin V production protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 354.0
TLS2_k127_2720033_10 Hep Hag repeat protein K19233,K21449 - - 0.00004217 53.0
TLS2_k127_2720033_2 Penicillin binding protein transpeptidase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 361.0
TLS2_k127_2720033_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008338 329.0
TLS2_k127_2720033_4 histone H2A K63-linked ubiquitination - - - 0.0000000000000000000000000000000000000000007177 167.0
TLS2_k127_2720033_5 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000007449 123.0
TLS2_k127_2720033_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000408 94.0
TLS2_k127_2720033_7 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - 0.0000000000004376 77.0
TLS2_k127_2720313_0 Aminotransferase class I and II K00652 - 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 605.0
TLS2_k127_2720313_1 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 410.0
TLS2_k127_2720313_2 Protein export membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 342.0
TLS2_k127_2720313_3 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000004964 121.0
TLS2_k127_2782178_0 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 415.0
TLS2_k127_2782178_1 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000002263 238.0
TLS2_k127_2782178_2 EamA-like transporter family - - - 0.000000000000000000000000002637 117.0
TLS2_k127_2839244_0 MMPL family K06994 - - 1.708e-288 901.0
TLS2_k127_2839244_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.155e-248 778.0
TLS2_k127_2839244_2 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 2.399e-200 638.0
TLS2_k127_2839244_3 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 404.0
TLS2_k127_2839244_4 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 384.0
TLS2_k127_2839244_5 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000002925 218.0
TLS2_k127_2839244_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000001733 205.0
TLS2_k127_2839244_7 Mediates zinc uptake. May also transport other divalent cations K07238 - - 0.0000000000000000000000000000000000305 138.0
TLS2_k127_2868716_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 591.0
TLS2_k127_2868716_1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 548.0
TLS2_k127_2889035_0 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta) - - - 1.549e-204 646.0
TLS2_k127_2889035_1 COG0402 Cytosine deaminase and related metal-dependent hydrolases K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 359.0
TLS2_k127_2889035_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772,K19696 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28,2.4.2.44 0.000000000000000000000000000000000000000000000000000002425 198.0
TLS2_k127_2898331_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 500.0
TLS2_k127_2898331_1 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000003531 141.0
TLS2_k127_2914615_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.116e-225 705.0
TLS2_k127_2914615_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008112 354.0
TLS2_k127_2914615_2 Nucleoside 2-deoxyribosyltransferase YtoQ - - - 0.00000000000000000000000000000000000000000000000000000000000000002139 231.0
TLS2_k127_2914615_3 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000001368 218.0
TLS2_k127_2914615_4 PFAM UspA - - - 0.00000000000000000000000000000000000000000000001361 177.0
TLS2_k127_2914615_5 Subtilase family - - - 0.0000000000000005669 83.0
TLS2_k127_2914615_6 Pfam:Pyridox_oxidase - - - 0.000003497 51.0
TLS2_k127_2948100_0 ABC 3 transport family K11708 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 533.0
TLS2_k127_2948100_1 ABC 3 transport family K11709 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 364.0
TLS2_k127_2948100_2 ABC-type metal ion transport system, periplasmic component surface adhesin K11707 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 321.0
TLS2_k127_2948100_3 PFAM ABC transporter K02074,K09820,K11710,K19973 - 3.6.3.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 308.0
TLS2_k127_2968995_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.64e-232 741.0
TLS2_k127_2968995_1 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 290.0
TLS2_k127_2968995_2 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000322 287.0
TLS2_k127_2968995_3 TIGRFAM DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000005873 211.0
TLS2_k127_2968995_4 - - - - 0.00000000000000000000000000000000000000008817 160.0
TLS2_k127_2968995_5 - - - - 0.000000000000000000000000738 121.0
TLS2_k127_2968995_6 Transcription regulator MerR DNA binding K13639 - - 0.0000000000000004955 87.0
TLS2_k127_2968995_7 SnoaL-like polyketide cyclase - - - 0.00000000000005388 80.0
TLS2_k127_299024_0 Cytochrome C and Quinol oxidase polypeptide I - - - 5.524e-274 859.0
TLS2_k127_299024_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 426.0
TLS2_k127_299024_10 Cytochrome C oxidase subunit II, transmembrane domain K02275 - 1.9.3.1 0.00000000000000000000000002355 119.0
TLS2_k127_299024_11 Glycosyl transferase 4-like domain - - - 0.000000000000000000000005133 104.0
TLS2_k127_299024_12 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257,K02259 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000007395 109.0
TLS2_k127_299024_13 - - - - 0.00000000000000000001692 101.0
TLS2_k127_299024_14 PFAM blue (type 1) copper domain protein K07243 - - 0.000000000000007723 84.0
TLS2_k127_299024_15 Cytochrome C oxidase subunit II, transmembrane domain - - - 0.000000000000007723 84.0
TLS2_k127_299024_16 Uncharacterized ACR, COG1430 K09005 - - 0.0000000009077 66.0
TLS2_k127_299024_2 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 364.0
TLS2_k127_299024_3 UbiA prenyltransferase family K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 306.0
TLS2_k127_299024_4 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005979 302.0
TLS2_k127_299024_5 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002374 286.0
TLS2_k127_299024_6 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001515 278.0
TLS2_k127_299024_7 Cytochrome C oxidase subunit II, transmembrane domain - - - 0.0000000000000000000000000000000000000000000001585 178.0
TLS2_k127_299024_8 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000002927 166.0
TLS2_k127_299024_9 EamA-like transporter family - - - 0.000000000000000000000000008504 114.0
TLS2_k127_300515_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 516.0
TLS2_k127_300515_1 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003538 264.0
TLS2_k127_300515_2 Multiple resistance and pH regulation protein F K05570 - - 0.000000000005857 70.0
TLS2_k127_300515_3 - - - - 0.0000008829 59.0
TLS2_k127_300515_4 Na+/H+ antiporter subunit K05571 - - 0.0002622 49.0
TLS2_k127_3006403_0 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 412.0
TLS2_k127_3006403_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 392.0
TLS2_k127_3006403_2 Cell cycle protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 363.0
TLS2_k127_3006403_3 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 364.0
TLS2_k127_3006403_4 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000895 334.0
TLS2_k127_3006403_5 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 299.0
TLS2_k127_3006403_6 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000001019 219.0
TLS2_k127_3006403_7 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000006194 77.0
TLS2_k127_3014099_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 342.0
TLS2_k127_3014099_1 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001236 263.0
TLS2_k127_302112_0 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 355.0
TLS2_k127_302112_1 Carbon-nitrogen hydrolase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 319.0
TLS2_k127_302112_2 YsiA-like protein, C-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001188 283.0
TLS2_k127_302112_3 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000000000000000006687 116.0
TLS2_k127_302112_4 translation release factor activity - - - 0.00000000000000003205 93.0
TLS2_k127_302112_5 STAS domain - - - 0.00000000001058 79.0
TLS2_k127_302112_6 - - - - 0.00000006332 63.0
TLS2_k127_302112_7 hydrolase of the alpha beta-hydrolase fold K07019 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 - 0.00000007262 65.0
TLS2_k127_302112_8 Anti-Sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.00002329 52.0
TLS2_k127_3062336_0 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 601.0
TLS2_k127_3062336_1 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 528.0
TLS2_k127_3062336_2 Appr-1'-p processing enzyme - GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231 - 0.000000000000000000000000000000000000000000000000000000000001224 214.0
TLS2_k127_3062336_3 Protein of unknown function (DUF692) K09930 - - 0.00000000000000000000000000000000000000000000000000000000007706 216.0
TLS2_k127_3062336_4 - - - - 0.000000000000000000000000000000000000000000000000000000001946 220.0
TLS2_k127_3062336_5 - - - - 0.000000000000000000000000000000000000000000000000003327 197.0
TLS2_k127_3062336_6 cyclase dehydrase - - - 0.0000000000000000000000000000000000000000005885 170.0
TLS2_k127_3062336_7 - - - - 0.00000000000000000000000000000000000000008518 162.0
TLS2_k127_3062336_8 - - - - 0.00000000002683 67.0
TLS2_k127_3082963_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 0.0 1117.0
TLS2_k127_3082963_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 2.997e-194 618.0
TLS2_k127_3082963_2 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006827 462.0
TLS2_k127_3082963_3 DNA polymerase K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 370.0
TLS2_k127_3082963_4 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009237 281.0
TLS2_k127_3175645_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 439.0
TLS2_k127_3175645_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 417.0
TLS2_k127_3175645_2 Putative NAD(P)-binding K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 322.0
TLS2_k127_3175645_3 Putative NAD(P)-binding K03499 - - 0.00000000000000000000000000000000000000000000000000006633 190.0
TLS2_k127_3187384_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 441.0
TLS2_k127_3187384_1 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001924 246.0
TLS2_k127_3187384_2 Inorganic H+ pyrophosphatase - - - 0.0000000000000000000000319 103.0
TLS2_k127_320368_0 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 470.0
TLS2_k127_320368_1 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005345 444.0
TLS2_k127_320368_10 acid phosphatase activity - - - 0.000000000000000000000000000000000001301 148.0
TLS2_k127_320368_11 ATP cob(I)alamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000009139 128.0
TLS2_k127_320368_12 OsmC-like protein K07397 - - 0.0000000000000000000000000001227 127.0
TLS2_k127_320368_13 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000008421 104.0
TLS2_k127_320368_2 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 440.0
TLS2_k127_320368_3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 436.0
TLS2_k127_320368_4 Short-chain Dehydrogenase reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001656 272.0
TLS2_k127_320368_5 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001806 275.0
TLS2_k127_320368_6 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001675 261.0
TLS2_k127_320368_7 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000003665 220.0
TLS2_k127_320368_8 - - - - 0.0000000000000000000000000000000000000000000000001013 193.0
TLS2_k127_320368_9 methyltransferase activity - - - 0.00000000000000000000000000000000000000000005804 167.0
TLS2_k127_3211149_0 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 550.0
TLS2_k127_3211149_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 526.0
TLS2_k127_3211149_2 Sigma-70 region 2 K03091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006956 311.0
TLS2_k127_3211149_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000005816 210.0
TLS2_k127_3211149_4 Iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000001216 210.0
TLS2_k127_3211149_5 Stage II sporulation protein E (SpoIIE) - - - 0.00007437 47.0
TLS2_k127_3239838_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 606.0
TLS2_k127_3239838_1 Spermine/spermidine synthase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 587.0
TLS2_k127_3239838_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 387.0
TLS2_k127_3239838_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 338.0
TLS2_k127_3239838_4 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.00000000000000000000000000000000000000000000000000000000000000005197 236.0
TLS2_k127_3239838_5 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000002239 196.0
TLS2_k127_3239838_6 Copper binding proteins, plastocyanin/azurin family - - - 0.00001342 56.0
TLS2_k127_3277342_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 428.0
TLS2_k127_3277342_1 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 358.0
TLS2_k127_3277342_2 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000000000000000000000000000000000000000203 172.0
TLS2_k127_3277342_3 Cold shock - - - 0.00000000000000000000000000000000007857 140.0
TLS2_k127_3277342_4 Rhomboid family - - - 0.00000000000006866 83.0
TLS2_k127_3277342_6 polysaccharide biosynthetic process - - - 0.0006506 52.0
TLS2_k127_3284800_0 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 520.0
TLS2_k127_3284800_1 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005495 521.0
TLS2_k127_3284800_2 Sigma-70 region 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 490.0
TLS2_k127_3284800_3 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 393.0
TLS2_k127_3284800_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000004843 228.0
TLS2_k127_3284800_5 YCII-related domain - - - 0.0000000000000000000000000000000002903 133.0
TLS2_k127_3309006_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 3.233e-219 690.0
TLS2_k127_3309006_1 DbpA RNA binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 505.0
TLS2_k127_3309006_2 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 385.0
TLS2_k127_3309006_3 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000000000000008804 246.0
TLS2_k127_3309006_4 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000002103 112.0
TLS2_k127_3309006_6 CARDB - - - 0.0000000002838 66.0
TLS2_k127_331102_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.005e-208 658.0
TLS2_k127_331102_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 393.0
TLS2_k127_331102_2 mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 303.0
TLS2_k127_331102_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000003339 212.0
TLS2_k127_331102_4 Telomere recombination K07566 - 2.7.7.87 0.00000000000000000000000000000000000000001074 168.0
TLS2_k127_331102_5 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000000003928 124.0
TLS2_k127_331102_6 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000007396 104.0
TLS2_k127_3424813_0 1-deoxy-D-xylulose-5-phosphate synthase K01662 - 2.2.1.7 1.781e-290 909.0
TLS2_k127_3424813_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 394.0
TLS2_k127_3424813_10 Protein of unknown function (DUF559) - - - 0.000000000000000000000000000000000001883 154.0
TLS2_k127_3424813_11 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000005451 122.0
TLS2_k127_3424813_2 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 370.0
TLS2_k127_3424813_3 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007022 328.0
TLS2_k127_3424813_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004047 306.0
TLS2_k127_3424813_5 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000002307 269.0
TLS2_k127_3424813_6 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001265 258.0
TLS2_k127_3424813_7 phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000001481 227.0
TLS2_k127_3424813_8 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000001171 210.0
TLS2_k127_3424813_9 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000002465 201.0
TLS2_k127_3442798_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 572.0
TLS2_k127_3442798_1 Histidyl-tRNA synthetase K02502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 347.0
TLS2_k127_3442798_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000002961 256.0
TLS2_k127_3442798_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000002461 257.0
TLS2_k127_3442798_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000316 204.0
TLS2_k127_3442798_5 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000276 198.0
TLS2_k127_3537469_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 471.0
TLS2_k127_3537469_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 409.0
TLS2_k127_3537469_2 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K03710,K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008845 379.0
TLS2_k127_3537469_3 Helix-turn-helix diphteria tox regulatory element - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 343.0
TLS2_k127_3537469_4 Belongs to the glycosyl hydrolase 18 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 326.0
TLS2_k127_3537469_5 HAD-superfamily hydrolase subfamily IA, variant 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 299.0
TLS2_k127_3537469_6 Sulfotransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000261 239.0
TLS2_k127_3537469_7 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000003504 223.0
TLS2_k127_3537469_8 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000002474 189.0
TLS2_k127_3541852_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 5.357e-197 634.0
TLS2_k127_3541852_1 Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain-like biotin carboxylase-like K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 582.0
TLS2_k127_3541852_2 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 446.0
TLS2_k127_3541852_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 286.0
TLS2_k127_3541852_4 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000000000000000005957 211.0
TLS2_k127_3541852_5 IstB-like ATP binding protein K02315 - - 0.00000000000000000000000000000000000000000000000000002846 197.0
TLS2_k127_3541852_6 Binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000000000000008258 186.0
TLS2_k127_3541852_7 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000006324 86.0
TLS2_k127_3541852_8 Protein of unknown function (DUF998) - - - 0.0000001685 62.0
TLS2_k127_3569859_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.14e-217 685.0
TLS2_k127_3569859_1 Fumarate hydratase class II K01679 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 535.0
TLS2_k127_3569859_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000269 198.0
TLS2_k127_3569859_3 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000004216 108.0
TLS2_k127_3569859_4 Stage II sporulation protein K06381 - - 0.00000000000001232 87.0
TLS2_k127_3569859_5 Subtilisin inhibitor-like - - - 0.000000000000104 82.0
TLS2_k127_3616369_0 UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006783 475.0
TLS2_k127_3616369_1 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 310.0
TLS2_k127_3616369_10 - - - - 0.00001431 57.0
TLS2_k127_3616369_2 Tartrate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000001024 267.0
TLS2_k127_3616369_3 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000001597 204.0
TLS2_k127_3616369_4 Non-ribosomal peptide synthetase modules and related proteins - - - 0.00000000000000000000000000000000000000000000000000000114 220.0
TLS2_k127_3616369_5 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000002319 192.0
TLS2_k127_3616369_6 Sulfotransferase domain - - - 0.000000000000000000000000000007828 128.0
TLS2_k127_3616369_7 ThiS family K03636 - - 0.00000000000000000000000001701 124.0
TLS2_k127_3616369_8 belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000397 75.0
TLS2_k127_3616369_9 - - - - 0.00000000001494 76.0
TLS2_k127_3678972_0 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005242 533.0
TLS2_k127_3678972_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00001885 53.0
TLS2_k127_3680834_0 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 597.0
TLS2_k127_3680834_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 406.0
TLS2_k127_3680834_2 impB/mucB/samB family C-terminal domain K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 340.0
TLS2_k127_3680834_3 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 308.0
TLS2_k127_3680834_4 Fusaric acid resistance protein-like - - - 0.000000000000000000000000000000000000000000000000000000397 207.0
TLS2_k127_3680834_5 Transglycosylase associated protein - - - 0.0000000000000000000000005302 106.0
TLS2_k127_3737799_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 3.149e-214 677.0
TLS2_k127_3737799_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 349.0
TLS2_k127_3737799_10 PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000008536 63.0
TLS2_k127_3737799_11 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000682 47.0
TLS2_k127_3737799_2 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006433 309.0
TLS2_k127_3737799_3 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000277 295.0
TLS2_k127_3737799_4 helix_turn_helix, cAMP Regulatory protein K21564 - - 0.0000000000000000000000000000000000000000000000000000000000000000009871 235.0
TLS2_k127_3737799_5 Formamidopyrimidine-DNA glycosylase H2TH domain K05522 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000007285 201.0
TLS2_k127_3737799_6 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000000001288 177.0
TLS2_k127_3737799_7 PFAM Protein-L-isoaspartate(D-aspartate) O-methyltransferase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000004178 196.0
TLS2_k127_3737799_8 PFAM 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000749 170.0
TLS2_k127_3737799_9 ASCH domain - - - 0.0000000000000000000000000000000000000000000139 166.0
TLS2_k127_3765122_0 PFAM catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009515 432.0
TLS2_k127_3765122_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 382.0
TLS2_k127_3802488_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 565.0
TLS2_k127_3802488_1 Ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 524.0
TLS2_k127_3802488_10 antibiotic catabolic process - - - 0.0000000000000000000000159 102.0
TLS2_k127_3802488_11 - - - - 0.000000000001354 76.0
TLS2_k127_3802488_12 - - - - 0.000000001824 66.0
TLS2_k127_3802488_13 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000001024 53.0
TLS2_k127_3802488_2 Thiolase, C-terminal domain K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 426.0
TLS2_k127_3802488_3 long-chain-acyl-CoA dehydrogenase activity K09479 GO:0000038,GO:0000062,GO:0000166,GO:0001659,GO:0003674,GO:0003824,GO:0003995,GO:0004466,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005829,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0006986,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009266,GO:0009295,GO:0009409,GO:0009628,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010033,GO:0010565,GO:0015980,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0017099,GO:0019216,GO:0019217,GO:0019218,GO:0019222,GO:0019395,GO:0019752,GO:0019866,GO:0023052,GO:0030154,GO:0030258,GO:0030554,GO:0030855,GO:0030968,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033554,GO:0034440,GO:0034620,GO:0034976,GO:0035966,GO:0035967,GO:0036094,GO:0036498,GO:0042221,GO:0042304,GO:0042592,GO:0042645,GO:0042760,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0046395,GO:0046890,GO:0048037,GO:0048519,GO:0048523,GO:0048856,GO:0048869,GO:0048871,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051055,GO:0051716,GO:0055114,GO:0060429,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071310,GO:0071704,GO:0072329,GO:0080090,GO:0090181,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 376.0
TLS2_k127_3802488_4 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 319.0
TLS2_k127_3802488_5 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000001746 192.0
TLS2_k127_3802488_6 Nitrogen regulatory protein P-II K04751 - - 0.0000000000000000000000000000000000000000000007358 168.0
TLS2_k127_3802488_7 - - - - 0.00000000000000000000000000000000000216 141.0
TLS2_k127_3802488_8 - - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000007058 114.0
TLS2_k127_3802488_9 Rhodanese Homology Domain - - - 0.000000000000000000000000513 109.0
TLS2_k127_3807155_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 2.182e-198 626.0
TLS2_k127_3807155_1 Transglycosylase-like domain - - - 0.000000000000000000000007846 113.0
TLS2_k127_3807155_2 sortase family K07284 - 3.4.22.70 0.000000000000000003482 93.0
TLS2_k127_3807155_3 universal stress protein - GO:0008150,GO:0040007 - 0.000003622 57.0
TLS2_k127_3851215_0 Tubulin/FtsZ family, GTPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 489.0
TLS2_k127_3851215_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 499.0
TLS2_k127_3851215_10 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000000000000000000000223 163.0
TLS2_k127_3851215_11 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000002847 155.0
TLS2_k127_3851215_12 Type II/IV secretion system protein K02669 - - 0.0000000000000000000002728 98.0
TLS2_k127_3851215_13 bifunctional deaminase-reductase domain protein - - - 0.0000000000000000001495 93.0
TLS2_k127_3851215_2 COG1335 Amidases related to nicotinamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 458.0
TLS2_k127_3851215_3 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 409.0
TLS2_k127_3851215_4 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 358.0
TLS2_k127_3851215_5 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009921 352.0
TLS2_k127_3851215_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 346.0
TLS2_k127_3851215_7 Anion-transporting ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000005408 244.0
TLS2_k127_3851215_8 Domain of unknown function (DUF1957) - - - 0.000000000000000000000000000000000000000000000000002806 192.0
TLS2_k127_3851215_9 - - - - 0.0000000000000000000000000000000000000000002898 179.0
TLS2_k127_3872934_0 HDOD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 371.0
TLS2_k127_3872934_1 MerR family regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002631 235.0
TLS2_k127_3872934_2 Transmembrane secretion effector - - - 0.00000000000000000000000001802 115.0
TLS2_k127_3872934_3 Helix-turn-helix domain - - - 0.0000000006493 63.0
TLS2_k127_3995203_0 Type III restriction enzyme, res subunit - - - 0.0 1117.0
TLS2_k127_3995203_1 Uroporphyrinogen-III synthase HemD K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008917 543.0
TLS2_k127_3995203_2 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000008169 235.0
TLS2_k127_3995203_3 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000003067 190.0
TLS2_k127_3995203_4 cell redox homeostasis K02199 - - 0.000000000000000000000000000000000000001757 154.0
TLS2_k127_3995203_5 TspO/MBR family K05770 - - 0.0000000000000000000000000003425 119.0
TLS2_k127_3995203_6 Methyltransferase domain - - - 0.00000000000000000000000002484 119.0
TLS2_k127_402220_0 Starch synthase catalytic domain K16150 - 2.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006747 557.0
TLS2_k127_402220_1 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 540.0
TLS2_k127_402220_2 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 533.0
TLS2_k127_402220_3 LAO AO transport system ATPase K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009301 428.0
TLS2_k127_402220_4 Eukaryotic DNA topoisomerase I, catalytic core - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 382.0
TLS2_k127_402220_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000022 292.0
TLS2_k127_402220_6 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002687 257.0
TLS2_k127_402220_7 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000001917 188.0
TLS2_k127_402220_8 Domain of unknown function (DUF1957) - - - 0.0000000000000000000000000000000000006795 147.0
TLS2_k127_402220_9 Domain of unknown function (DUF2382) - - - 0.00000002927 64.0
TLS2_k127_4067057_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 370.0
TLS2_k127_4067057_1 PQQ enzyme repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005614 278.0
TLS2_k127_4067057_2 Poly A polymerase head domain K00974 - 2.7.7.72 0.00000000000000000000000000000000001929 141.0
TLS2_k127_4067057_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000002994 59.0
TLS2_k127_407106_0 helicase superfamily c-terminal domain K03654 - 3.6.4.12 1.089e-203 657.0
TLS2_k127_407106_1 Haloacid dehalogenase-like hydrolase K02566 - - 0.000000000000000000000000000002526 126.0
TLS2_k127_407106_2 ABC transporter - - - 0.00000000000000000000000000004183 116.0
TLS2_k127_4123336_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004707 518.0
TLS2_k127_4123336_1 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000004069 192.0
TLS2_k127_4123336_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000008812 105.0
TLS2_k127_414077_0 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000003111 248.0
TLS2_k127_414077_1 PFAM MaoC domain protein dehydratase - - - 0.0000000000000000000000000000000000000000001516 164.0
TLS2_k127_414077_2 Enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000009949 110.0
TLS2_k127_414077_3 Cytochrome c - - - 0.00000000000000007296 86.0
TLS2_k127_4166079_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 362.0
TLS2_k127_4166079_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005714 327.0
TLS2_k127_4166079_10 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000002477 113.0
TLS2_k127_4166079_11 YGGT family K02221 - - 0.00000000000001026 86.0
TLS2_k127_4166079_2 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 301.0
TLS2_k127_4166079_3 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000004891 261.0
TLS2_k127_4166079_4 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005307 254.0
TLS2_k127_4166079_5 Alanine racemase, N-terminal domain K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000001742 245.0
TLS2_k127_4166079_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000003168 233.0
TLS2_k127_4166079_7 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 - - 0.0000000000000000000000000000000000000000000000000000000001534 212.0
TLS2_k127_4166079_8 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.00000000000000000000000000000000000000000000000000000002816 205.0
TLS2_k127_4166079_9 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000001189 145.0
TLS2_k127_4174267_0 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004687 273.0
TLS2_k127_4174267_1 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006261 262.0
TLS2_k127_4174267_2 ligase activity - - - 0.000000000000000000000000000000000000000000000009697 177.0
TLS2_k127_4174267_3 Permeases of the drug metabolite transporter DMT superfamily - - - 0.0000000000000000000000000000000000008177 151.0
TLS2_k127_418361_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005527 496.0
TLS2_k127_418361_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 368.0
TLS2_k127_418361_10 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000009421 101.0
TLS2_k127_418361_11 Belongs to the UPF0109 family K06960 - - 0.000000000000000004201 88.0
TLS2_k127_418361_2 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 315.0
TLS2_k127_418361_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000275 254.0
TLS2_k127_418361_4 RecF/RecN/SMC N terminal domain K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000005099 239.0
TLS2_k127_418361_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000004358 241.0
TLS2_k127_418361_6 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000000002806 192.0
TLS2_k127_418361_7 magnesium chelatase, ChlI subunit K07391 - - 0.00000000000000000000000000000000000002414 153.0
TLS2_k127_418361_8 Stress responsive A/B Barrel Domain - - - 0.000000000000000000000000001843 123.0
TLS2_k127_418361_9 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000007776 110.0
TLS2_k127_4250696_0 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 315.0
TLS2_k127_4250696_1 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000002345 223.0
TLS2_k127_4250696_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000001474 103.0
TLS2_k127_4333077_0 Circularly permuted ATP-grasp type 2 - - - 1.598e-218 712.0
TLS2_k127_4333077_1 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 495.0
TLS2_k127_4333077_2 Bacterial transglutaminase-like N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 342.0
TLS2_k127_4333077_3 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 303.0
TLS2_k127_4333077_4 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001128 289.0
TLS2_k127_4333077_5 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000002235 241.0
TLS2_k127_440263_0 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 445.0
TLS2_k127_440263_1 cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 372.0
TLS2_k127_440263_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002208 258.0
TLS2_k127_440263_3 helix_turn_helix, Lux Regulon K02479 - - 0.0000000000000000000000000000000000000000002248 167.0
TLS2_k127_440263_4 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000003146 171.0
TLS2_k127_440263_5 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000001127 156.0
TLS2_k127_440263_6 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 GO:0005575,GO:0005576 1.3.3.11 0.000000000000000002633 100.0
TLS2_k127_440263_8 Protein of unknown function (DUF1298) - - - 0.0000006026 61.0
TLS2_k127_4420786_0 Homoserine dehydrogenase K00003,K12524 - 1.1.1.3,2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 518.0
TLS2_k127_4420786_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 513.0
TLS2_k127_4420786_2 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004721 269.0
TLS2_k127_4420786_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000006367 253.0
TLS2_k127_4440012_0 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 290.0
TLS2_k127_4440012_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000132 269.0
TLS2_k127_4440012_2 transferase activity, transferring amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001093 256.0
TLS2_k127_4440012_3 Bacterial sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001261 231.0
TLS2_k127_4440012_4 Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. - - - 0.000000000000000000000000000000000000000000000000005024 196.0
TLS2_k127_4440012_5 Protein of unknown function (DUF3105) - - - 0.000000000000000000000000002622 121.0
TLS2_k127_4440012_6 Acetyltransferase (GNAT) domain - - - 0.0000000000005231 78.0
TLS2_k127_4443056_0 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 451.0
TLS2_k127_4443056_1 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000001148 141.0
TLS2_k127_4443056_2 Glutaredoxin K07390 - - 0.00000000000000000000000000000001365 131.0
TLS2_k127_4443056_3 Belongs to the BolA IbaG family - - - 0.00000000004698 65.0
TLS2_k127_4450652_0 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 1.194e-300 938.0
TLS2_k127_4450652_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 287.0
TLS2_k127_4450652_2 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000879 280.0
TLS2_k127_4450652_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000001252 118.0
TLS2_k127_4450652_4 Winged helix DNA-binding domain - - - 0.0000000000000003448 83.0
TLS2_k127_4477197_0 COG COG0210 Superfamily I DNA and RNA helicases DNA replication recombination and repair K03657 - 3.6.4.12 3.193e-258 814.0
TLS2_k127_4477197_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 519.0
TLS2_k127_4477197_10 Transcriptional regulator - - - 0.0000000000000000000000000000000000001873 145.0
TLS2_k127_4477197_11 PFAM Response regulator receiver domain, Bacterial regulatory proteins, luxR family - - - 0.00000000000000032 87.0
TLS2_k127_4477197_12 Binding-protein-dependent transport system inner membrane component - - - 0.000000000007246 67.0
TLS2_k127_4477197_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009782 488.0
TLS2_k127_4477197_3 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009373 401.0
TLS2_k127_4477197_4 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 373.0
TLS2_k127_4477197_5 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 340.0
TLS2_k127_4477197_6 AP endonuclease family 2 K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 328.0
TLS2_k127_4477197_7 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 333.0
TLS2_k127_4477197_8 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005723 295.0
TLS2_k127_4477197_9 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005743 278.0
TLS2_k127_4506294_0 Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000523 597.0
TLS2_k127_4506294_1 NmrA-like family K00091 - 1.1.1.219 0.000000000000000000000000000000000000003981 155.0
TLS2_k127_4506294_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000003774 89.0
TLS2_k127_4541099_0 KR domain K13774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 321.0
TLS2_k127_4541099_1 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003024 257.0
TLS2_k127_4541099_2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01476,K01480 - 3.5.3.1,3.5.3.11 0.00000000000000000000000000000000000000000000000000000000002376 217.0
TLS2_k127_4541099_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000001774 183.0
TLS2_k127_4541099_4 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000001075 123.0
TLS2_k127_45804_0 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005805 281.0
TLS2_k127_45804_1 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006694 238.0
TLS2_k127_45804_2 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000000000008484 222.0
TLS2_k127_45804_3 - - - - 0.0000000000000000000000000000000001602 147.0
TLS2_k127_4621112_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001671 273.0
TLS2_k127_4621112_1 sugar phosphate - - - 0.000000000000000000000000000000000000000000000000000000000000008816 231.0
TLS2_k127_4621112_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000000000019 184.0
TLS2_k127_4621112_3 Protein of unknown function (DUF1360) - - - 0.000000000000000000000000000000000000006677 155.0
TLS2_k127_4621112_4 Thioredoxin-like - - - 0.0000000000000000000000001271 114.0
TLS2_k127_4621112_5 Cytochrome C biogenesis protein K02200 - - 0.00000000000000000002182 104.0
TLS2_k127_4621112_7 - - - - 0.00000006303 63.0
TLS2_k127_4662120_0 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 484.0
TLS2_k127_4662120_1 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 361.0
TLS2_k127_4662120_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 290.0
TLS2_k127_4662120_3 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003877 266.0
TLS2_k127_4662120_4 B12 binding domain K22491 - - 0.00000000000000000000000000000000000000000000000000000000000000005345 234.0
TLS2_k127_4662120_5 Type III restriction protein res subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000006614 229.0
TLS2_k127_4662120_6 Auxin Efflux Carrier K07088 - - 0.000000000000000000000000000000000000000000000000000000000000023 226.0
TLS2_k127_4662120_7 Dehydrogenase - - - 0.000000000005479 70.0
TLS2_k127_4739701_0 Class-II DAHP synthetase family K01626 - 2.5.1.54 7.777e-236 736.0
TLS2_k127_4739701_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 537.0
TLS2_k127_4739701_2 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 523.0
TLS2_k127_4739701_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000001437 159.0
TLS2_k127_4746521_0 Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily K01661 - 4.1.3.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 411.0
TLS2_k127_4746521_1 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 287.0
TLS2_k127_4746521_2 AMP-binding enzyme C-terminal domain K01911 - 6.2.1.26 0.000000000000000000000000000000000000000000000000005694 200.0
TLS2_k127_47539_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 5.546e-285 882.0
TLS2_k127_47539_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.085e-244 771.0
TLS2_k127_47539_10 Dodecin K09165 - - 0.00003125 52.0
TLS2_k127_47539_11 - - - - 0.00003749 51.0
TLS2_k127_47539_2 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 520.0
TLS2_k127_47539_3 Ornithine cyclodeaminase/mu-crystallin family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 356.0
TLS2_k127_47539_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001298 247.0
TLS2_k127_47539_5 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000002788 198.0
TLS2_k127_47539_6 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000005905 165.0
TLS2_k127_47539_7 - - - - 0.0000000000000000000004159 104.0
TLS2_k127_47539_8 HD domain - - - 0.000000006656 65.0
TLS2_k127_47539_9 - - - - 0.000003796 60.0
TLS2_k127_4894784_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 3.679e-248 792.0
TLS2_k127_4894784_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 310.0
TLS2_k127_4894784_2 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000002737 143.0
TLS2_k127_4930556_0 Amidase K01426 - 3.5.1.4 0.0 1225.0
TLS2_k127_4930556_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 337.0
TLS2_k127_4930556_2 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 289.0
TLS2_k127_4930556_3 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000004519 143.0
TLS2_k127_4930556_4 Transcriptional regulator - - - 0.00000000000000000000000000000003237 128.0
TLS2_k127_4930556_5 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000002474 108.0
TLS2_k127_4930556_7 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000001152 61.0
TLS2_k127_4930556_8 META domain - - - 0.00006545 55.0
TLS2_k127_4948865_0 Ribonucleotide reductase, small chain K00526 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009274 394.0
TLS2_k127_4948865_1 O-methyltransferase K00588,K16028,K21189 - 2.1.1.104 0.000000000000000000000000000000000000000000000000000000000000004334 223.0
TLS2_k127_4948865_2 Rhomboid family K19225 - 3.4.21.105 0.0000007086 58.0
TLS2_k127_4948865_3 acetyltransferase - - - 0.000005476 57.0
TLS2_k127_4948865_4 Sigma-70 region 2 - - - 0.000005591 57.0
TLS2_k127_4954764_0 MMPL family - - - 2.229e-276 868.0
TLS2_k127_4971574_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 477.0
TLS2_k127_4971574_1 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 401.0
TLS2_k127_4971574_2 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004496 265.0
TLS2_k127_4971574_3 Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000000000000000000000000000000000000000000000000007757 248.0
TLS2_k127_4971574_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000057 108.0
TLS2_k127_4971574_5 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000007715 102.0
TLS2_k127_4971574_6 - - - - 0.00000000000009376 81.0
TLS2_k127_4971574_8 Domain of unknown function (DUF4383) - - - 0.00000005624 61.0
TLS2_k127_4971574_9 - - - - 0.0000007538 59.0
TLS2_k127_5021551_0 Daunorubicin resistance ABC transporter ATP-binding subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 389.0
TLS2_k127_5021551_1 Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 389.0
TLS2_k127_5021551_2 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 319.0
TLS2_k127_5021551_3 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001919 291.0
TLS2_k127_5021551_4 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000136 218.0
TLS2_k127_5021551_5 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000000000000000000002595 127.0
TLS2_k127_5021551_6 - - - - 0.00000000000000000003234 100.0
TLS2_k127_5021551_7 - - - - 0.00000000000000001626 89.0
TLS2_k127_5031560_0 Glutamate synthase - - - 5.566e-246 807.0
TLS2_k127_5031560_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 585.0
TLS2_k127_5031560_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 512.0
TLS2_k127_5031560_3 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005743 458.0
TLS2_k127_5031560_4 FAD linked oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 338.0
TLS2_k127_5031560_5 oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000001107 241.0
TLS2_k127_5031560_6 - - - - 0.00000000000001168 76.0
TLS2_k127_5031560_8 membrane protein (DUF2078) K08982 - - 0.0000644 49.0
TLS2_k127_5036287_0 Belongs to the GPI family K01810 - 5.3.1.9 1.156e-260 812.0
TLS2_k127_5036287_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 564.0
TLS2_k127_5036287_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 459.0
TLS2_k127_5036287_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 371.0
TLS2_k127_5036287_4 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002831 373.0
TLS2_k127_5036287_5 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000215 219.0
TLS2_k127_5036287_6 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000001651 112.0
TLS2_k127_5040184_0 WYL domain K13573 - - 2.584e-247 782.0
TLS2_k127_5040184_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K03698 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 361.0
TLS2_k127_5040184_2 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002293 284.0
TLS2_k127_5040184_3 Metallo-beta-lactamase superfamily - - - 0.000000000000001606 83.0
TLS2_k127_5073123_0 PD-(D/E)XK nuclease superfamily K03657 - 3.6.4.12 6.261e-222 708.0
TLS2_k127_5073123_1 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 319.0
TLS2_k127_5073123_2 OB-fold nucleic acid binding domain K03698 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006914 320.0
TLS2_k127_5073123_3 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000001084 223.0
TLS2_k127_5073123_4 - - - - 0.00000000000000000000000000000003213 140.0
TLS2_k127_5073123_5 response to heat K07090 - - 0.000000000000000000000000001748 128.0
TLS2_k127_5073123_6 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000225 116.0
TLS2_k127_5073123_7 DNA polymerase X K02347 - - 0.000000005406 57.0
TLS2_k127_5073123_8 Protein of unknown function (DUF2855) - - - 0.000001866 52.0
TLS2_k127_5073123_9 cell adhesion - - - 0.0001992 50.0
TLS2_k127_5095852_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 419.0
TLS2_k127_5095852_1 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007287 402.0
TLS2_k127_5181384_0 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 336.0
TLS2_k127_5181384_1 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003246 287.0
TLS2_k127_5181384_2 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000002627 193.0
TLS2_k127_5181384_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000003453 121.0
TLS2_k127_5181384_4 - - - - 0.000001612 50.0
TLS2_k127_5227824_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 473.0
TLS2_k127_5227824_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005255 463.0
TLS2_k127_5227824_10 glycerophosphoryl diester phosphodiesterase - - - 0.000000000000000000000000000000000000000000003805 177.0
TLS2_k127_5227824_11 endonuclease activity K06877,K07451 - - 0.0000000000000000000000000000004617 133.0
TLS2_k127_5227824_2 unusual protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008522 449.0
TLS2_k127_5227824_3 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 329.0
TLS2_k127_5227824_4 PucR C-terminal helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 316.0
TLS2_k127_5227824_5 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007577 307.0
TLS2_k127_5227824_6 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000001815 223.0
TLS2_k127_5227824_7 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000007188 203.0
TLS2_k127_5227824_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000003458 198.0
TLS2_k127_5227824_9 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000005207 184.0
TLS2_k127_52413_0 COG COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase Amino acid transport and metabolism Coenzyme metabolism K01652 - 2.2.1.6 4.876e-218 690.0
TLS2_k127_52413_1 Belongs to the aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 427.0
TLS2_k127_52413_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 344.0
TLS2_k127_52413_3 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 295.0
TLS2_k127_52413_4 acetyltransferase - - - 0.00000000000000000000000000000002048 136.0
TLS2_k127_52413_5 - - - - 0.000000000000000000000000009627 112.0
TLS2_k127_5252229_0 Glutamate synthase central domain K00265 - 1.4.1.13,1.4.1.14 3.563e-199 654.0
TLS2_k127_5252229_1 Homoserine dehydrogenase K00003,K12524 - 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005459 510.0
TLS2_k127_5252229_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 494.0
TLS2_k127_5252229_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 466.0
TLS2_k127_5252229_4 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008751 322.0
TLS2_k127_5324058_0 MMPL family - - - 4.838e-210 675.0
TLS2_k127_5324058_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 290.0
TLS2_k127_5324058_2 DNA-binding transcription factor activity K03892,K07721,K22042,K22491 - - 0.00000000000000000000000000064 115.0
TLS2_k127_5324058_3 Saccharopine dehydrogenase NADP binding domain K12445 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030312,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000002484 59.0
TLS2_k127_5324058_4 - - - - 0.0002384 51.0
TLS2_k127_5327652_0 Acyltransferase, ws dgat mgat K00635 - 2.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 434.0
TLS2_k127_5327652_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 371.0
TLS2_k127_5327652_2 phosphoribosyltransferase K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000005424 217.0
TLS2_k127_5327652_3 negative regulation of translational initiation - - - 0.000000000000000000000000000000000006339 142.0
TLS2_k127_5344473_0 MMPL family - - - 8.47e-233 742.0
TLS2_k127_5344473_1 DNA primase, small subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 598.0
TLS2_k127_5344473_10 Hep Hag repeat protein K19233,K21449 - - 0.00000000000115 81.0
TLS2_k127_5344473_11 - - - - 0.000000000002958 74.0
TLS2_k127_5344473_12 positive regulation of growth - GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0015643,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351 - 0.000000000007603 71.0
TLS2_k127_5344473_13 Antitoxin component of a toxin-antitoxin (TA) module - GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351 - 0.0000000002458 66.0
TLS2_k127_5344473_14 cellulase activity - - - 0.00000001122 66.0
TLS2_k127_5344473_15 - - - - 0.000007611 55.0
TLS2_k127_5344473_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 403.0
TLS2_k127_5344473_3 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002711 291.0
TLS2_k127_5344473_4 PIN domain - - - 0.000000000000000000000000000000001014 136.0
TLS2_k127_5344473_5 Nuclease-related domain - - - 0.000000000000000000000000000000004909 138.0
TLS2_k127_5344473_6 Belongs to the 'phage' integrase family - - - 0.0000000000000000000001268 110.0
TLS2_k127_5344473_7 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000002543 101.0
TLS2_k127_5344473_8 Hep Hag repeat protein K19233,K21449 - - 0.00000000000002199 83.0
TLS2_k127_5344473_9 - - - - 0.0000000000000375 81.0
TLS2_k127_5364697_0 UDP binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 531.0
TLS2_k127_5364697_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 - 1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 511.0
TLS2_k127_5364697_2 Peptidase family S51 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 313.0
TLS2_k127_5364697_3 Peptidase family S51 - - - 0.00000000000000000000000000000000000000000000000000000000005709 219.0
TLS2_k127_5364697_4 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms - - - 0.0000000000000000000000000000000001711 144.0
TLS2_k127_5392018_0 C-terminal domain of alpha-glycerophosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 496.0
TLS2_k127_5392018_1 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 311.0
TLS2_k127_5392018_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000006356 208.0
TLS2_k127_5392018_3 transposition K07497 - - 0.000000000000000000000000000000000000000001532 169.0
TLS2_k127_5392018_4 - - - - 0.000000000000001798 76.0
TLS2_k127_5408431_0 Alanine-glyoxylate amino-transferase K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 603.0
TLS2_k127_5408431_1 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 567.0
TLS2_k127_5408431_10 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 316.0
TLS2_k127_5408431_11 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006188 280.0
TLS2_k127_5408431_12 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001256 275.0
TLS2_k127_5408431_13 Rieske 2Fe-2S - - - 0.00000000000000000000000000000000000000000000000000000000000000001078 231.0
TLS2_k127_5408431_14 Cytochrome b subunit of the bc K03888 - - 0.000000000000000000000000000000000000000000000000000000003421 203.0
TLS2_k127_5408431_15 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000005318 154.0
TLS2_k127_5408431_16 Polymorphic membrane protein, Chlamydia - - - 0.00000000000000000000000000000000000006323 158.0
TLS2_k127_5408431_17 GtrA-like protein - - - 0.0000000000000000000000000000000000004246 145.0
TLS2_k127_5408431_18 - - - - 0.000000000000000000000000000000009094 134.0
TLS2_k127_5408431_19 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.0000000001072 70.0
TLS2_k127_5408431_2 AsnC-type helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 510.0
TLS2_k127_5408431_3 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 477.0
TLS2_k127_5408431_4 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 431.0
TLS2_k127_5408431_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 436.0
TLS2_k127_5408431_6 Cytochrome b K03887 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 362.0
TLS2_k127_5408431_7 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 361.0
TLS2_k127_5408431_8 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 363.0
TLS2_k127_5408431_9 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 341.0
TLS2_k127_5440225_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008576 455.0
TLS2_k127_5440225_1 PFAM dehydrogenase, E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 428.0
TLS2_k127_5440225_2 PFAM Transketolase central region K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 432.0
TLS2_k127_5440225_3 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005995 309.0
TLS2_k127_5440225_4 Catalytic domain of components of various dehydrogenase complexes K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000001868 183.0
TLS2_k127_5440225_5 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000141 134.0
TLS2_k127_5498106_0 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008535 380.0
TLS2_k127_5498106_1 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002136 252.0
TLS2_k127_5498106_2 D-arabinono-1,4-lactone oxidase K00103 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016491,GO:0016627,GO:0016632,GO:0019752,GO:0019852,GO:0019853,GO:0030312,GO:0042364,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046364,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0080049,GO:1901576 1.1.3.8 0.0000000000000000000000000000000000000000000000000001668 201.0
TLS2_k127_5498106_3 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000002908 148.0
TLS2_k127_5498106_4 Membrane - - - 0.00000000000000000000000000000006859 134.0
TLS2_k127_5498106_5 Belongs to the glycosyl hydrolase 26 family - - - 0.000000000007269 77.0
TLS2_k127_5498106_6 Subtilisin inhibitor-like - - - 0.000001519 57.0
TLS2_k127_5518478_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 3.366e-232 751.0
TLS2_k127_5518478_1 DHH family K07462 - - 1.747e-202 660.0
TLS2_k127_5518478_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 550.0
TLS2_k127_5518478_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 462.0
TLS2_k127_5518478_4 transcription factor binding - - - 0.00000000000000000000000000000000000000000000000000000000000000001378 228.0
TLS2_k127_5518478_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000005463 223.0
TLS2_k127_5518478_6 - - - - 0.000000000000006582 90.0
TLS2_k127_5573459_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001626 289.0
TLS2_k127_5573459_1 Histidine kinase - - - 0.00000000000000000000000000005491 135.0
TLS2_k127_5573459_2 STAS domain K06378 - - 0.0000000001515 66.0
TLS2_k127_5573459_3 Protein of unknown function (DUF1365) K09701 - - 0.00001025 51.0
TLS2_k127_5573459_4 Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition K06379 - 2.7.11.1 0.0000411 52.0
TLS2_k127_5621341_0 UDP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 363.0
TLS2_k127_5621341_1 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 327.0
TLS2_k127_5621341_2 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 322.0
TLS2_k127_5621341_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000002183 146.0
TLS2_k127_5621341_4 inositol 2-dehydrogenase activity K13018 - 2.3.1.201 0.000000000004118 71.0
TLS2_k127_564041_0 GTP-binding protein TypA K06207 - - 6.627e-261 816.0
TLS2_k127_564041_1 Belongs to the anaerobic coproporphyrinogen-III oxidase family K02495 - 1.3.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 411.0
TLS2_k127_564041_2 Peptidase C26 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006751 276.0
TLS2_k127_564041_3 tellurite resistance protein TehB K16868 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0010035,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046690,GO:0050896 2.1.1.265 0.00000000000000000000000000000000000000000000000000000000000000000000008045 251.0
TLS2_k127_564041_4 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.00000000000000000000000000000000000000000000003401 191.0
TLS2_k127_5657961_0 Thymidylate synthase complementing protein - - - 7.356e-221 696.0
TLS2_k127_5657961_1 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000005934 237.0
TLS2_k127_5657961_2 DJ-1/PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000001452 181.0
TLS2_k127_5657961_3 - - - - 0.00000000000000000000000000009708 123.0
TLS2_k127_5657961_4 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000000000001404 108.0
TLS2_k127_5657961_5 - - - - 0.0000000006055 70.0
TLS2_k127_5657961_6 histidine kinase, dimerisation and phosphoacceptor region K02480 - 2.7.13.3 0.000000005418 61.0
TLS2_k127_5657961_7 Methyltransferase domain - - - 0.0006388 50.0
TLS2_k127_565892_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008672 541.0
TLS2_k127_565892_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000009106 173.0
TLS2_k127_565892_2 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000001318 170.0
TLS2_k127_565892_3 bleomycin resistance protein - - - 0.00000000000000000000000003211 112.0
TLS2_k127_565892_4 Evidence 4 Homologs of previously reported genes of - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0000000000000000000000385 102.0
TLS2_k127_565892_5 Acetoacetate decarboxylase (ADC) - - - 0.000000000000000000166 98.0
TLS2_k127_565892_6 PFAM GGDEF domain containing protein - - - 0.0000001658 55.0
TLS2_k127_5724508_0 Acyl-CoA synthetase (NDP forming) K09181 - - 4.308e-271 861.0
TLS2_k127_5724508_1 ATPase (P-type) K01537,K12952 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 361.0
TLS2_k127_5724508_2 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004377 278.0
TLS2_k127_5724508_3 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004641 263.0
TLS2_k127_5724508_4 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000001724 224.0
TLS2_k127_5724508_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000001859 117.0
TLS2_k127_5724508_6 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00000006689 60.0
TLS2_k127_5724508_7 CBS domain containing protein K07182 - - 0.000001579 60.0
TLS2_k127_5724508_8 Belongs to the universal stress protein A family - GO:0000166,GO:0001666,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008144,GO:0008150,GO:0009628,GO:0016020,GO:0017076,GO:0022611,GO:0030312,GO:0030554,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036293,GO:0040007,GO:0040008,GO:0043167,GO:0043168,GO:0044111,GO:0044114,GO:0044115,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0051704,GO:0065007,GO:0070482,GO:0071944,GO:0085014,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00001228 57.0
TLS2_k127_5724508_9 Reductase C-terminal K00529 - 1.18.1.3 0.00008364 53.0
TLS2_k127_5737364_0 YibE/F-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007751 297.0
TLS2_k127_5737364_1 PFAM lipopolysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000005235 227.0
TLS2_k127_5737364_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000006633 173.0
TLS2_k127_5737364_3 Peptidase family M23 K21471 - - 0.0000000000003678 80.0
TLS2_k127_5744051_0 Pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 601.0
TLS2_k127_5744051_1 Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004135 258.0
TLS2_k127_577721_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.225e-297 925.0
TLS2_k127_5781283_0 MMPL family - - - 1.695e-196 639.0
TLS2_k127_5781283_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 385.0
TLS2_k127_5781283_2 3'-5' exonuclease activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 303.0
TLS2_k127_5781283_3 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006473 286.0
TLS2_k127_5781283_4 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000003348 214.0
TLS2_k127_5807001_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.0 1163.0
TLS2_k127_5807001_1 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 469.0
TLS2_k127_5807001_10 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.00000000000000008791 93.0
TLS2_k127_5807001_11 - - - - 0.0000004227 59.0
TLS2_k127_5807001_12 - - - - 0.0008605 49.0
TLS2_k127_5807001_2 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 448.0
TLS2_k127_5807001_3 PFAM molybdopterin dehydrogenase, FAD-binding K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 382.0
TLS2_k127_5807001_4 von Willebrand factor, type A K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 344.0
TLS2_k127_5807001_5 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000001701 261.0
TLS2_k127_5807001_6 MobA-Related Protein K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000000000000000000000000008536 249.0
TLS2_k127_5807001_7 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000005851 267.0
TLS2_k127_5807001_8 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000006176 152.0
TLS2_k127_5807001_9 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.000000000000000000000000000000004035 133.0
TLS2_k127_5897308_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 608.0
TLS2_k127_5897308_1 hydrolase, family 3 K01207 - 3.2.1.52 0.000000000000000000000000000000000000000001134 180.0
TLS2_k127_5897308_2 Thioesterase superfamily - - - 0.0000000000000000000000000000000004998 135.0
TLS2_k127_5897308_3 Ion channel - - - 0.0000000000000000000000001742 115.0
TLS2_k127_5897308_4 - - - - 0.0000000000000000000002538 104.0
TLS2_k127_5897308_5 polysaccharide catabolic process K03478 - 3.5.1.105 0.0000000000000008611 90.0
TLS2_k127_5897308_6 DNA-templated transcription, initiation - - - 0.00000000004857 75.0
TLS2_k127_5913027_0 Carboxyl transferase domain - - - 4.143e-245 780.0
TLS2_k127_5913027_1 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 451.0
TLS2_k127_5913027_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 358.0
TLS2_k127_5913027_3 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003024 262.0
TLS2_k127_5934129_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 518.0
TLS2_k127_5934129_1 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 456.0
TLS2_k127_5934129_10 - - - - 0.0003243 52.0
TLS2_k127_5934129_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000003598 221.0
TLS2_k127_5934129_3 acetyltransferase - - - 0.00000000000000000000000000000000000000000000003638 177.0
TLS2_k127_5934129_4 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000539 177.0
TLS2_k127_5934129_5 Thioesterase - - - 0.000000000000000000000000000000000005195 149.0
TLS2_k127_5934129_6 negative regulation of translational initiation - - - 0.000000001595 69.0
TLS2_k127_5934129_7 exo-alpha-(2->6)-sialidase activity K20276 - - 0.00000006489 65.0
TLS2_k127_5934129_8 Hep Hag repeat protein K19233,K21449 - - 0.0000001179 63.0
TLS2_k127_5934129_9 metallopeptidase activity K08738,K20276 - - 0.00005154 56.0
TLS2_k127_6002176_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 467.0
TLS2_k127_6002176_1 DEAD/H associated K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 383.0
TLS2_k127_6002176_2 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000638 155.0
TLS2_k127_6003502_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.024e-212 682.0
TLS2_k127_6003502_1 Ppx GppA phosphatase K01524 GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237 3.6.1.11,3.6.1.40 0.000000000000000002635 89.0
TLS2_k127_6012935_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 344.0
TLS2_k127_6012935_1 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 332.0
TLS2_k127_6012935_2 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004839 250.0
TLS2_k127_6012935_3 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000003047 182.0
TLS2_k127_6020398_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 3.341e-194 619.0
TLS2_k127_6020398_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 515.0
TLS2_k127_6020398_2 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000819 295.0
TLS2_k127_6020398_3 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000000000000000000009103 162.0
TLS2_k127_6020398_4 Transcriptional regulator - - - 0.00000000000000000000000000006554 121.0
TLS2_k127_608923_0 Elongation factor G, domain IV K02355 - - 9.316e-295 920.0
TLS2_k127_608923_1 RNA polymerase sigma factor K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 354.0
TLS2_k127_608923_2 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008546 329.0
TLS2_k127_608923_3 - - - - 0.000000000000003196 85.0
TLS2_k127_6089278_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 2.864e-297 937.0
TLS2_k127_6089278_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 434.0
TLS2_k127_6089278_2 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000008724 88.0
TLS2_k127_6089889_0 Glutaminase K01425 - 3.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 569.0
TLS2_k127_6089889_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009688 406.0
TLS2_k127_6089889_2 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 315.0
TLS2_k127_6089889_3 Formiminotransferase domain, N-terminal subdomain K00603 - 2.1.2.5 0.000000000000000000000000000000000000000000000001294 179.0
TLS2_k127_6092504_0 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 480.0
TLS2_k127_6092504_1 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000000000000003584 104.0
TLS2_k127_6115243_0 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 543.0
TLS2_k127_6115243_1 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009389 279.0
TLS2_k127_6115243_2 Forkhead associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001305 232.0
TLS2_k127_6123088_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.534e-310 962.0
TLS2_k127_6123088_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 306.0
TLS2_k127_6123088_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 314.0
TLS2_k127_6123088_3 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000001004 256.0
TLS2_k127_6123088_4 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000001714 202.0
TLS2_k127_6123088_5 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000006044 200.0
TLS2_k127_6123088_6 Dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000000000000000000000000000000000007011 154.0
TLS2_k127_6123088_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000001235 154.0
TLS2_k127_6150286_0 RNA polymerase sigma factor K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 362.0
TLS2_k127_6150286_1 Phage integrase, N-terminal SAM-like domain K03733 - - 0.0000000000000000000000000000001016 124.0
TLS2_k127_6150286_2 - - - - 0.00000000000007911 78.0
TLS2_k127_6150286_3 Reverse transcriptase-like K03469,K22316 - 3.1.26.4,3.1.3.73 0.0001109 46.0
TLS2_k127_6164697_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007185 327.0
TLS2_k127_6164697_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000002995 224.0
TLS2_k127_6164697_2 Ham1 family K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000004774 212.0
TLS2_k127_6164697_3 Helix-turn-helix domain - - - 0.000000000000685 74.0
TLS2_k127_6204818_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 396.0
TLS2_k127_6204818_1 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007827 288.0
TLS2_k127_6204818_2 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000000000008089 228.0
TLS2_k127_6204818_3 CcmB protein K02194 - - 0.00000000000000000000000000000000000000000000000000000000003011 228.0
TLS2_k127_6204818_4 Penicillin-insensitive murein endopeptidase K07261 - - 0.00000000001726 77.0
TLS2_k127_6204818_6 Beta-L-arabinofuranosidase, GH127 - - - 0.00001486 57.0
TLS2_k127_621689_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 519.0
TLS2_k127_621689_1 Type I GTP cyclohydrolase folE2 K09007 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 400.0
TLS2_k127_621689_2 Threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 379.0
TLS2_k127_621689_3 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 323.0
TLS2_k127_621689_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000000000001887 221.0
TLS2_k127_621689_5 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000001247 149.0
TLS2_k127_621689_6 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000003452 63.0
TLS2_k127_621689_7 acyl-CoA dehydrogenase - - - 0.000002602 49.0
TLS2_k127_6229305_0 glycosyl transferase, family 51 K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 559.0
TLS2_k127_6229305_1 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005778 508.0
TLS2_k127_6229305_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 365.0
TLS2_k127_6229305_3 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000003219 240.0
TLS2_k127_6229305_4 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000001422 224.0
TLS2_k127_6229305_5 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000009905 208.0
TLS2_k127_6229305_6 aminopeptidase activity - - - 0.0000000000000000000000000000000000000007917 168.0
TLS2_k127_6229305_7 HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.00000000000000000000000000000000001032 158.0
TLS2_k127_6229305_8 CAAX protease self-immunity K07052 - - 0.000000000000000000000003751 115.0
TLS2_k127_6234341_0 Carboxypeptidase - - - 0.0 1064.0
TLS2_k127_6234341_1 Isocitrate/isopropylmalate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007455 454.0
TLS2_k127_6234341_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 456.0
TLS2_k127_6234341_3 saccharopine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 409.0
TLS2_k127_6234341_4 Beta propeller domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 357.0
TLS2_k127_6234341_5 OsmC-like protein K04063 - - 0.000000000000000000000000000000000000000627 153.0
TLS2_k127_6275146_0 Acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 402.0
TLS2_k127_6275146_1 Epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 319.0
TLS2_k127_6275146_2 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000005773 235.0
TLS2_k127_6275146_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000008063 236.0
TLS2_k127_62989_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 505.0
TLS2_k127_62989_1 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 436.0
TLS2_k127_6313006_0 Drug exporters of the RND superfamily K06994,K07003 - - 9.724e-203 654.0
TLS2_k127_6313006_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003186 269.0
TLS2_k127_6318425_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 1.074e-213 676.0
TLS2_k127_6318425_1 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 323.0
TLS2_k127_6318425_2 cell envelope-related transcriptional attenuator - - - 0.0000000000000000000000000000000000000000000000000002168 200.0
TLS2_k127_6318425_3 Protein of unknown function (DUF559) - - - 0.00000000000000000000000000000000000000000001896 175.0
TLS2_k127_6318425_4 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000002442 119.0
TLS2_k127_6318425_5 Regulatory protein, FmdB - - - 0.00000000000000003376 95.0
TLS2_k127_6318425_6 Protein of unknown function (DUF3467) - - - 0.00000000008721 70.0
TLS2_k127_636861_0 Ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 8.542e-273 850.0
TLS2_k127_636861_1 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 612.0
TLS2_k127_636861_2 Ferredoxin oxidoreductase K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 476.0
TLS2_k127_636861_3 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 309.0
TLS2_k127_636861_4 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000001852 244.0
TLS2_k127_636861_5 phosphoesterases, related to the Icc protein - - - 0.00000000000000000000000000000000000000000000000000000000001075 218.0
TLS2_k127_636861_6 Lipoate-protein ligase - - - 0.0000000000000000000000000000000000000000000249 171.0
TLS2_k127_636861_7 Transglycosylase-like domain - - - 0.000000000000000000000001285 115.0
TLS2_k127_6380971_0 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 460.0
TLS2_k127_6380971_1 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001285 263.0
TLS2_k127_6380971_2 binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000005253 230.0
TLS2_k127_6380971_3 NMT1/THI5 like K15598 - - 0.00000000000000000000000000000000000000000000001026 180.0
TLS2_k127_6390077_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000002598 160.0
TLS2_k127_6390077_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000001358 132.0
TLS2_k127_6390077_2 AAA domain - - - 0.0000000000000000001273 97.0
TLS2_k127_6404045_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 4.34e-225 714.0
TLS2_k127_6404045_1 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 582.0
TLS2_k127_6404045_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 413.0
TLS2_k127_6404045_3 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000004577 203.0
TLS2_k127_6404045_4 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000001122 184.0
TLS2_k127_6404045_5 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00002632 53.0
TLS2_k127_640712_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1345.0
TLS2_k127_640712_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 1.138e-283 937.0
TLS2_k127_640712_2 DNA polymerase X K02347 - - 3.027e-194 628.0
TLS2_k127_640712_3 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006212 270.0
TLS2_k127_640712_4 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000004084 160.0
TLS2_k127_640712_5 Belongs to the 4-oxalocrotonate tautomerase family K01821 - 5.3.2.6 0.0000000007293 61.0
TLS2_k127_642927_0 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 384.0
TLS2_k127_642927_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 338.0
TLS2_k127_642927_10 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000409 108.0
TLS2_k127_642927_11 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.000000000000001308 89.0
TLS2_k127_642927_12 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000002172 59.0
TLS2_k127_642927_2 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 318.0
TLS2_k127_642927_3 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 304.0
TLS2_k127_642927_4 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006257 275.0
TLS2_k127_642927_5 PFAM 60 kDa inner membrane insertion protein K03217 - - 0.000000000000000000000000000000000000000000000000000000000008102 216.0
TLS2_k127_642927_6 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000005882 193.0
TLS2_k127_642927_7 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000000000000000000000001235 182.0
TLS2_k127_642927_8 single-stranded nucleic acid binding R3H K06346 - - 0.00000000000000000000000000000000000003076 148.0
TLS2_k127_642927_9 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000000000009971 129.0
TLS2_k127_6502607_0 Uncharacterized protein family (UPF0051) K09014 - - 3.136e-254 790.0
TLS2_k127_6502607_1 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 601.0
TLS2_k127_6502607_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 458.0
TLS2_k127_6502607_3 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009861 428.0
TLS2_k127_6502607_4 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000000003598 172.0
TLS2_k127_6502607_5 Rieske 2Fe-2S iron-sulphur domain K05710 - - 0.00000000000000000000000000000000000000006008 153.0
TLS2_k127_6502607_6 - - - - 0.0000000000000006226 83.0
TLS2_k127_6530896_0 domain, Protein - - - 0.00000000000000000000000000000000006509 151.0
TLS2_k127_6530896_1 Methyltransferase K02493 - 2.1.1.297 0.000000000000000000000001267 108.0
TLS2_k127_6530896_2 Virulence factor BrkB K07058 - - 0.000000000000000003131 95.0
TLS2_k127_6530896_3 - - - - 0.0000000004006 64.0
TLS2_k127_6530896_4 SurA N-terminal domain - - - 0.00006954 56.0
TLS2_k127_6560762_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 4.576e-205 661.0
TLS2_k127_6560762_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001836 277.0
TLS2_k127_6560762_2 PFAM OsmC family protein - - - 0.000000000000000000000000000000000000000000000102 172.0
TLS2_k127_6560762_3 Pfam Small Multidrug Resistance protein K11741 - - 0.000000000000000000000000008583 115.0
TLS2_k127_6560762_4 Preprotein translocase SecG subunit - - - 0.00000000000000000000005296 105.0
TLS2_k127_6560762_5 CcmE - - - 0.00000000000000000000005809 113.0
TLS2_k127_6560762_6 - - - - 0.000000000006371 69.0
TLS2_k127_6561299_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 489.0
TLS2_k127_6561299_1 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 346.0
TLS2_k127_6561299_2 Alanine-glyoxylate amino-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 302.0
TLS2_k127_6561299_3 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007563 285.0
TLS2_k127_6561299_4 PFAM conserved K02069 - - 0.000000000000000000000000000000000000000000003408 181.0
TLS2_k127_6561299_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02068,K06857 - 3.6.3.55 0.00000000000000000000000000000000000000001087 167.0
TLS2_k127_6561299_6 Smr domain - - - 0.000000000000000000000000000000000000002783 151.0
TLS2_k127_6561299_7 Belongs to the UPF0235 family K09131 - - 0.00000000003904 68.0
TLS2_k127_6576506_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808 480.0
TLS2_k127_6576506_1 Aldehyde dehydrogenase family K00147 - 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006275 473.0
TLS2_k127_6576506_2 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 435.0
TLS2_k127_6576506_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000005584 185.0
TLS2_k127_6576506_4 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000001179 130.0
TLS2_k127_6576506_5 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000004573 122.0
TLS2_k127_6580352_0 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 494.0
TLS2_k127_6580352_1 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 431.0
TLS2_k127_6580352_2 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000003099 237.0
TLS2_k127_6587888_0 BPG-independent PGAM N-terminus (iPGM_N) K15633 - 5.4.2.12 6.585e-197 632.0
TLS2_k127_6587888_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000063 470.0
TLS2_k127_6587888_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 418.0
TLS2_k127_6587888_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 319.0
TLS2_k127_6587888_4 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 287.0
TLS2_k127_6587888_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004011 280.0
TLS2_k127_6587888_6 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000001405 231.0
TLS2_k127_6587888_7 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000001865 228.0
TLS2_k127_6587888_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000008057 147.0
TLS2_k127_6620524_0 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000007278 225.0
TLS2_k127_6620524_1 PPIC-type PPIASE domain K07533 - 5.2.1.8 0.0000000000000000000000000000000009 147.0
TLS2_k127_6644735_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 413.0
TLS2_k127_6644735_1 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000738 258.0
TLS2_k127_6644735_2 Pfam Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000002051 163.0
TLS2_k127_6644735_3 MMPL family - - - 0.0000000000000000000000001587 108.0
TLS2_k127_6644735_4 Hemerythrin HHE cation binding domain - - - 0.000000001123 62.0
TLS2_k127_6644998_0 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 579.0
TLS2_k127_6644998_1 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 486.0
TLS2_k127_6644998_2 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 308.0
TLS2_k127_6644998_3 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002879 244.0
TLS2_k127_6657303_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 531.0
TLS2_k127_6657303_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000001721 83.0
TLS2_k127_6669123_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 471.0
TLS2_k127_6669123_1 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000003229 235.0
TLS2_k127_6669123_2 PD-(D/E)XK nuclease superfamily K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000002856 194.0
TLS2_k127_6669123_3 - - - - 0.000001952 52.0
TLS2_k127_6685030_0 Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 2.207e-263 833.0
TLS2_k127_6685030_1 PFAM NAD-dependent epimerase dehydratase K06118 - 3.13.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 577.0
TLS2_k127_6685030_2 chorismate binding enzyme K02552 - 5.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 460.0
TLS2_k127_6685030_3 Thermolysin metallopeptidase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 362.0
TLS2_k127_6685030_4 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001149 275.0
TLS2_k127_6685030_5 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.0000000000000000000000000000000000000000000000000000001686 206.0
TLS2_k127_6685030_6 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000004449 156.0
TLS2_k127_6685030_7 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000001476 113.0
TLS2_k127_6692781_0 Protein of unknown function, DUF255 K06888 - - 1.024e-258 813.0
TLS2_k127_6692781_1 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 538.0
TLS2_k127_6692781_10 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000001132 180.0
TLS2_k127_6692781_11 regulation of RNA biosynthetic process - - - 0.0000000000000000000000002478 122.0
TLS2_k127_6692781_13 - K04517 - 1.3.1.12 0.000000000000000000000001623 111.0
TLS2_k127_6692781_15 Prokaryotic N-terminal methylation motif - - - 0.000000000000005789 82.0
TLS2_k127_6692781_16 Belongs to the Fur family K03711,K22297 - - 0.000000000004276 71.0
TLS2_k127_6692781_17 - - - - 0.0000001659 63.0
TLS2_k127_6692781_18 Antibiotic biosynthesis monooxygenase - - - 0.0000002415 57.0
TLS2_k127_6692781_19 Manganese containing catalase - - - 0.0003888 47.0
TLS2_k127_6692781_2 Sterol-sensing domain of SREBP cleavage-activation K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 502.0
TLS2_k127_6692781_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 500.0
TLS2_k127_6692781_4 seryl-tRNA aminoacylation K01875 GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 449.0
TLS2_k127_6692781_5 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 379.0
TLS2_k127_6692781_6 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 309.0
TLS2_k127_6692781_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003976 254.0
TLS2_k127_6692781_8 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000001579 233.0
TLS2_k127_6692781_9 Type IV leader peptidase family K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000001699 181.0
TLS2_k127_6698160_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 614.0
TLS2_k127_6698160_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001349 258.0
TLS2_k127_6698160_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000003207 150.0
TLS2_k127_6698160_3 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000008382 118.0
TLS2_k127_6698160_4 CsbD-like - - - 0.000009527 51.0
TLS2_k127_6708849_0 DNA integrity scanning protein DisA K07067 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 494.0
TLS2_k127_6708849_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 314.0
TLS2_k127_6708849_2 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006367 253.0
TLS2_k127_6708849_3 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000000000000000000000000000006213 141.0
TLS2_k127_6726015_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 3.432e-228 719.0
TLS2_k127_6726015_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.037e-217 692.0
TLS2_k127_6726015_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 446.0
TLS2_k127_6726015_3 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000001043 232.0
TLS2_k127_6726015_4 Methyltransferase domain K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000008342 231.0
TLS2_k127_6726015_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000003663 243.0
TLS2_k127_6757507_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 464.0
TLS2_k127_6757507_1 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 352.0
TLS2_k127_6757507_2 impB/mucB/samB family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003917 337.0
TLS2_k127_6757507_3 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000001124 213.0
TLS2_k127_6757507_4 Helix-hairpin-helix motif K14162 - 2.7.7.7 0.00000000000000000000000000000000000005685 150.0
TLS2_k127_6757507_5 - - - - 0.000000000000002003 84.0
TLS2_k127_6768138_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.709e-269 869.0
TLS2_k127_6768138_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 518.0
TLS2_k127_6768138_10 Ribosomal protein S20 K02968 - - 0.00000000000000000000183 97.0
TLS2_k127_6768138_11 Uncharacterised protein family (UPF0093) - - - 0.0000000000000281 84.0
TLS2_k127_6768138_2 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 454.0
TLS2_k127_6768138_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006412 370.0
TLS2_k127_6768138_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000397 341.0
TLS2_k127_6768138_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 304.0
TLS2_k127_6768138_6 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 302.0
TLS2_k127_6768138_7 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000007939 240.0
TLS2_k127_6768138_8 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000003774 189.0
TLS2_k127_6768138_9 Yqey-like protein K09117 - - 0.00000000000000000000000000000000002346 139.0
TLS2_k127_6849029_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 406.0
TLS2_k127_6849029_1 Thermophilic metalloprotease (M29) K19689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 381.0
TLS2_k127_6849029_2 Helix-turn-helix domain, rpiR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 349.0
TLS2_k127_6849029_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000004681 206.0
TLS2_k127_6849029_4 domain, Protein - - - 0.0000000000000000000000000000000000000000000000003363 191.0
TLS2_k127_6849029_5 Domain of unknown function (DUF368) K08974 - - 0.000000000000000000000000000000000000000001977 163.0
TLS2_k127_6860951_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0 1926.0
TLS2_k127_6860951_1 Nitrate reductase beta subunit K00371 - 1.7.5.1 2e-227 734.0
TLS2_k127_6860951_2 Major Facilitator Superfamily K02575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000327 280.0
TLS2_k127_6860951_3 Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000001603 222.0
TLS2_k127_6860951_4 Nitrate reductase delta subunit K00373 - - 0.00000000000000000000000000000000000000000002319 171.0
TLS2_k127_6923047_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0 1211.0
TLS2_k127_6923047_1 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009762 544.0
TLS2_k127_6923047_2 PFAM Ion transport protein K08714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009794 310.0
TLS2_k127_6923047_3 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000001385 254.0
TLS2_k127_6923047_4 Peptidoglycan-binding domain 1 protein K21471 - - 0.00000000000000000000000000000000003135 144.0
TLS2_k127_6981718_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 8.466e-248 781.0
TLS2_k127_6981718_1 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 3.418e-205 675.0
TLS2_k127_6981718_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 441.0
TLS2_k127_6981718_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005636 259.0
TLS2_k127_6981718_4 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000001946 228.0
TLS2_k127_6981718_5 tRNA rRNA methyltransferase, SpoU K03437 - - 0.0000000000000000000000000000000000000000000000000001333 200.0
TLS2_k127_6981718_6 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000003387 143.0
TLS2_k127_6981718_7 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000008562 90.0
TLS2_k127_6982048_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 4.748e-219 704.0
TLS2_k127_6982048_1 HD-GYP domain - - - 0.0000000000000000000000000000000000000000000000000000000001222 216.0
TLS2_k127_6982048_2 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000007864 165.0
TLS2_k127_6982048_3 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000006592 132.0
TLS2_k127_6982048_4 divalent heavy-metal cations transporter K07238 - - 0.000000000000007775 77.0
TLS2_k127_6987430_0 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 517.0
TLS2_k127_6987430_1 Oligoendopeptidase f K01283 - 3.4.15.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 429.0
TLS2_k127_6987430_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 336.0
TLS2_k127_6987430_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 314.0
TLS2_k127_6987430_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000002801 225.0
TLS2_k127_6987430_5 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000395 149.0
TLS2_k127_6987430_6 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000009711 139.0
TLS2_k127_6987430_8 peptidase inhibitor activity - - - 0.0000000000001601 78.0
TLS2_k127_6987430_9 PFAM Cysteine-rich secretory protein family - - - 0.00000000001576 66.0
TLS2_k127_7035372_0 PHP-associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 492.0
TLS2_k127_7035372_1 Uracil DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 304.0
TLS2_k127_7035372_2 - - - - 0.000009161 49.0
TLS2_k127_7068908_0 Carboxyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 572.0
TLS2_k127_7068908_1 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 484.0
TLS2_k127_7068908_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 342.0
TLS2_k127_7068908_3 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 342.0
TLS2_k127_7068908_4 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001134 299.0
TLS2_k127_7068908_5 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000003915 131.0
TLS2_k127_7068908_6 MaoC like domain - - - 0.0000000000000000000000001806 119.0
TLS2_k127_7068908_7 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000002465 108.0
TLS2_k127_7068908_8 Belongs to the HAD-like hydrolase superfamily K02566 - - 0.000000000000003447 76.0
TLS2_k127_7068908_9 Phosphopantetheine attachment site K02078 - - 0.0000000000003058 82.0
TLS2_k127_708581_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 578.0
TLS2_k127_708581_1 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 375.0
TLS2_k127_7090036_0 Voltage gated chloride channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 436.0
TLS2_k127_7090036_1 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007079 301.0
TLS2_k127_7090036_2 Transketolase, central region K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 308.0
TLS2_k127_7090036_3 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000000001424 186.0
TLS2_k127_7107900_0 phosphatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001585 268.0
TLS2_k127_7107900_1 Carbon-nitrogen hydrolase K01501 GO:0000257,GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0016787,GO:0016810,GO:0016815,GO:0018762,GO:0022607,GO:0043933,GO:0044085,GO:0051259,GO:0051260,GO:0065003,GO:0071840 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000004706 242.0
TLS2_k127_7107900_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000005917 183.0
TLS2_k127_7107900_3 Alpha/beta hydrolase family - - - 0.0000000000000000005937 94.0
TLS2_k127_7110726_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.528e-250 800.0
TLS2_k127_7110726_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 395.0
TLS2_k127_7110726_10 Copper transport outer membrane protein, MctB - - - 0.00000000000009374 83.0
TLS2_k127_7110726_11 PFAM PspC domain protein K03973 - - 0.000000000006871 74.0
TLS2_k127_7110726_12 Thiamin pyrophosphokinase, catalytic - - - 0.00000000004444 65.0
TLS2_k127_7110726_2 Peptidase dimerisation domain K01258 - 3.4.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 326.0
TLS2_k127_7110726_3 Protein of unknown function (DUF3866) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 328.0
TLS2_k127_7110726_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005581 280.0
TLS2_k127_7110726_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001656 261.0
TLS2_k127_7110726_6 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000003715 261.0
TLS2_k127_7110726_7 Peptidase family S58 - - - 0.000000000000000000000000000000000000000000000000000000000002902 230.0
TLS2_k127_7110726_8 NUDIX domain - - - 0.00000000000000000000000000000000000000388 154.0
TLS2_k127_7110726_9 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000004863 128.0
TLS2_k127_7133355_0 Glutamine amidotransferase of anthranilate synthase K13950 - 2.6.1.85 1.059e-214 685.0
TLS2_k127_7133355_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000002723 192.0
TLS2_k127_7133355_2 Peptidase M1, membrane alanine aminopeptidase - - - 0.00000000000000000000000000000000000000000000001162 184.0
TLS2_k127_7137488_0 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002667 273.0
TLS2_k127_7137488_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004085 274.0
TLS2_k127_7137488_10 - - - - 0.0000000000000007428 84.0
TLS2_k127_7137488_2 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000005828 223.0
TLS2_k127_7137488_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000001206 209.0
TLS2_k127_7137488_4 SelR domain K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000001309 196.0
TLS2_k127_7137488_5 histidine kinase, dimerisation and phosphoacceptor region K02480 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000005378 198.0
TLS2_k127_7137488_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000001689 127.0
TLS2_k127_7137488_7 Cytochrome c - - - 0.000000000000000000000000000003963 123.0
TLS2_k127_7137488_8 Flavin reductase like domain - - - 0.00000000000000000000000000001422 124.0
TLS2_k127_7137488_9 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000002071 104.0
TLS2_k127_7166377_0 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.0 1008.0
TLS2_k127_7166377_1 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 536.0
TLS2_k127_7166377_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 524.0
TLS2_k127_7166377_3 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 439.0
TLS2_k127_7166377_4 Phosphoribosyl transferase domain K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000002371 264.0
TLS2_k127_7166377_5 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000002591 197.0
TLS2_k127_7166377_6 Alpha/beta hydrolase family - - - 0.0000005783 57.0
TLS2_k127_7174372_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 9.958e-297 921.0
TLS2_k127_7236411_0 Aldo/keto reductase family K18471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 391.0
TLS2_k127_7236411_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 301.0
TLS2_k127_7236411_2 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000004694 175.0
TLS2_k127_7332896_0 Zinc-binding dehydrogenase K14446 - 1.3.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 490.0
TLS2_k127_7354228_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 555.0
TLS2_k127_7354228_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000004339 75.0
TLS2_k127_7354228_2 - - - - 0.0000000004285 65.0
TLS2_k127_7368595_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 614.0
TLS2_k127_7368595_1 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 529.0
TLS2_k127_7368595_2 NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004646 282.0
TLS2_k127_7368595_3 - - - - 0.000000000000006343 76.0
TLS2_k127_7368595_4 - - - - 0.000000000000007629 87.0
TLS2_k127_7368595_5 Thioredoxin - - - 0.000000002654 68.0
TLS2_k127_7368595_6 Alpha/beta hydrolase family K01563 - 3.8.1.5 0.00000001747 56.0
TLS2_k127_7368595_7 D-alanyl-D-alanine carboxypeptidase K07259 - 3.4.16.4 0.00000003111 63.0
TLS2_k127_7444085_0 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 312.0
TLS2_k127_7444085_1 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008124 259.0
TLS2_k127_7444085_2 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000001858 141.0
TLS2_k127_7444085_3 O-antigen ligase like membrane protein - - - 0.000000000000000006879 91.0
TLS2_k127_7444085_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000002593 79.0
TLS2_k127_7444085_5 cellulase activity - - - 0.000000000000005687 84.0
TLS2_k127_763968_0 E1-E2 ATPase K12952 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000372 286.0
TLS2_k127_783742_0 Excinuclease ATPase subunit - - - 1.543e-225 701.0
TLS2_k127_783742_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006417 356.0
TLS2_k127_783742_2 Formate/nitrite transporter K06212 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 303.0
TLS2_k127_783742_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000009573 252.0
TLS2_k127_810763_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 355.0
TLS2_k127_810763_1 FR47-like protein K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000005879 202.0
TLS2_k127_810763_2 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.0000000000000000000000000008909 120.0
TLS2_k127_810763_3 Glutaredoxin-like domain (DUF836) - - - 0.00000000002537 76.0
TLS2_k127_810763_4 Glycoprotease family K14742 - - 0.0000000001675 64.0
TLS2_k127_822084_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 8.549e-208 653.0
TLS2_k127_822084_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 443.0
TLS2_k127_822084_2 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 407.0
TLS2_k127_822084_3 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000001583 252.0
TLS2_k127_822084_4 asparagine synthase - - - 0.00000000000000000000000000000000000004219 161.0
TLS2_k127_835871_0 hydrolase family 65, central catalytic K01194,K01838,K04844,K05342 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944 2.4.1.64,3.2.1.28,5.4.2.6 4.956e-300 954.0
TLS2_k127_835871_1 Type II secretion system (T2SS), protein E, N-terminal domain K02652 - - 9.205e-195 636.0
TLS2_k127_835871_2 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 523.0
TLS2_k127_835871_3 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 499.0
TLS2_k127_835871_4 COG COG1459 Type II secretory pathway component PulF Cell motility and secretion Intracellular trafficking and secretion K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008933 414.0
TLS2_k127_835871_5 phosphonoacetaldehyde hydrolase activity K01087,K01194,K01838,K05342 GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000662 269.0
TLS2_k127_835871_6 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000009346 246.0
TLS2_k127_835871_7 response regulator - - - 0.000000000001421 76.0
TLS2_k127_835871_8 - - - - 0.000000008925 66.0
TLS2_k127_851924_0 ABC transporter transmembrane region K11085 - - 4.331e-195 626.0
TLS2_k127_851924_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 396.0
TLS2_k127_851924_2 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 298.0
TLS2_k127_851924_3 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003266 284.0
TLS2_k127_851924_4 Phosphotransferase enzyme family - - - 0.000000004748 63.0
TLS2_k127_857135_0 PFAM ABC transporter related K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 456.0
TLS2_k127_857135_1 TOBE-like domain K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000711 428.0
TLS2_k127_857135_2 Binding-protein-dependent transport system inner membrane component K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 316.0
TLS2_k127_857135_3 PFAM Substrate-binding region of ABC-type glycine betaine transport system K05845 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 307.0
TLS2_k127_857135_4 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003887 284.0
TLS2_k127_857135_5 binding-protein-dependent transport systems inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000333 248.0
TLS2_k127_857135_6 binding-protein-dependent transport systems inner membrane component K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000642 224.0
TLS2_k127_857135_7 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000008839 193.0
TLS2_k127_857135_8 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000005248 136.0
TLS2_k127_89037_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 4.473e-256 816.0
TLS2_k127_89037_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 496.0
TLS2_k127_89037_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000003428 233.0
TLS2_k127_89037_3 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000002412 184.0
TLS2_k127_89037_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000001606 178.0
TLS2_k127_89037_5 peptidoglycan biosynthetic process - - - 0.0000000000000000000000000000000000000001807 156.0
TLS2_k127_89037_6 Protein of unknown function (DUF3352) - - - 0.000366 53.0
TLS2_k127_91050_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.178e-292 914.0
TLS2_k127_91050_1 MFS_1 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008377 293.0
TLS2_k127_91050_2 Thioesterase - - - 0.00000000004101 66.0
TLS2_k127_917792_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000008929 170.0
TLS2_k127_917792_1 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000003198 175.0
TLS2_k127_917792_2 O-Antigen ligase - - - 0.0000000000000000000000000000001738 141.0
TLS2_k127_917792_3 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000635 138.0
TLS2_k127_917792_4 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000004825 128.0
TLS2_k127_917792_5 Sulfotransferase domain - - - 0.00000000000000000002025 107.0
TLS2_k127_917792_6 ATPase MipZ - - - 0.0000000000000000003519 100.0
TLS2_k127_917792_7 Sulfotransferase family - - - 0.0000000000000219 87.0
TLS2_k127_917792_8 Methyltransferase FkbM domain - - - 0.000000009561 66.0
TLS2_k127_952764_0 Aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 503.0
TLS2_k127_952764_1 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 439.0
TLS2_k127_952764_2 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 413.0
TLS2_k127_952764_3 AAA domain, putative AbiEii toxin, Type IV TA system K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 419.0
TLS2_k127_952764_4 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 371.0
TLS2_k127_952764_5 Protein export membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002043 288.0
TLS2_k127_952764_6 Glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001978 280.0
TLS2_k127_952764_7 Cold shock protein K03704 - - 0.00000000000000000000005398 102.0
TLS2_k127_952764_8 - - - - 0.00000000001423 74.0
TLS2_k127_956715_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.577e-226 714.0
TLS2_k127_956715_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 442.0
TLS2_k127_956715_2 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000001056 218.0
TLS2_k127_956715_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000006137 61.0
TLS2_k127_964500_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 6.752e-202 641.0
TLS2_k127_964500_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 514.0
TLS2_k127_964500_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000001035 203.0
TLS2_k127_964500_3 Membrane - - - 0.0000000000000000000000000000000000000000000000000002609 192.0
TLS2_k127_964500_4 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000000006514 132.0
TLS2_k127_987866_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006209 538.0
TLS2_k127_987866_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 461.0
TLS2_k127_987866_2 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 369.0
TLS2_k127_987866_3 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 361.0
TLS2_k127_987866_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000009106 157.0
TLS2_k127_987866_5 GYD domain - - - 0.000000000000000000000000000001369 123.0
TLS2_k127_987866_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000001205 105.0
TLS2_k127_987866_7 protein conserved in bacteria K21600 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000001316 111.0