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Overview

ID MAG04017
Name TLS2_bin.57
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Gemmatimonadales
Family GWC2-71-9
Genus JAWXBA01
Species
Assembly information
Completeness (%) 98.92
Contamination (%) 0.87
GC content (%) 68.0
N50 (bp) 47,186
Genome size (bp) 3,532,252

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2894

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1015859_0 with chaperone activity ATP-binding K03696 - - 1.087e-307 966.0
TLS2_k127_1015859_1 Bacterial membrane protein YfhO - - - 3.907e-220 707.0
TLS2_k127_1015859_10 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 464.0
TLS2_k127_1015859_11 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000705 452.0
TLS2_k127_1015859_12 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 437.0
TLS2_k127_1015859_13 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 415.0
TLS2_k127_1015859_14 ATP:guanido phosphotransferase, C-terminal catalytic domain K19405 - 2.7.14.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 386.0
TLS2_k127_1015859_15 ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 376.0
TLS2_k127_1015859_16 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 367.0
TLS2_k127_1015859_17 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 335.0
TLS2_k127_1015859_18 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 333.0
TLS2_k127_1015859_19 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009274 324.0
TLS2_k127_1015859_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 7e-215 683.0
TLS2_k127_1015859_20 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 319.0
TLS2_k127_1015859_21 PFAM Sodium calcium exchanger protein K07300 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 329.0
TLS2_k127_1015859_22 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 317.0
TLS2_k127_1015859_23 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 304.0
TLS2_k127_1015859_24 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 311.0
TLS2_k127_1015859_25 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 308.0
TLS2_k127_1015859_26 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001268 288.0
TLS2_k127_1015859_27 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000001194 279.0
TLS2_k127_1015859_28 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001483 264.0
TLS2_k127_1015859_29 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000002494 250.0
TLS2_k127_1015859_3 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 7.053e-207 651.0
TLS2_k127_1015859_30 Bacillithiol biosynthesis BshC K22136 - - 0.00000000000000000000000000000000000000000000000000000000005857 223.0
TLS2_k127_1015859_31 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000491 207.0
TLS2_k127_1015859_32 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000003884 213.0
TLS2_k127_1015859_33 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000346 209.0
TLS2_k127_1015859_34 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000347 200.0
TLS2_k127_1015859_35 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000003281 187.0
TLS2_k127_1015859_36 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000002301 170.0
TLS2_k127_1015859_37 - - - - 0.000000000000000000000000000000000000000001567 163.0
TLS2_k127_1015859_38 peptidase activity, acting on L-amino acid peptides K07004,K09955,K12567,K21449 - 2.7.11.1 0.00000000000000000000000000000000000000007449 176.0
TLS2_k127_1015859_39 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000003141 150.0
TLS2_k127_1015859_4 Surface antigen K07277 - - 2.429e-197 643.0
TLS2_k127_1015859_40 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000000003975 154.0
TLS2_k127_1015859_41 UvrB/uvrC motif K19411 - - 0.00000000000000000000000000000000003437 141.0
TLS2_k127_1015859_42 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000006891 137.0
TLS2_k127_1015859_43 Lipopolysaccharide-assembly, LptC-related - - - 0.000000000000000000000000000003982 126.0
TLS2_k127_1015859_44 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000001359 123.0
TLS2_k127_1015859_45 peptidase activity, acting on L-amino acid peptides K20276 - - 0.0000000000000000000006027 113.0
TLS2_k127_1015859_46 - - - - 0.00000000000000000009182 89.0
TLS2_k127_1015859_47 chaperone-mediated protein folding - - - 0.000000000000000001448 99.0
TLS2_k127_1015859_48 Belongs to the UPF0434 family K09791 - - 0.00000000000000003622 87.0
TLS2_k127_1015859_49 Outer membrane protein (OmpH-like) K06142 - - 0.0000000000000003222 86.0
TLS2_k127_1015859_5 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 608.0
TLS2_k127_1015859_50 Methyltransferase domain - - - 0.00000000000004104 83.0
TLS2_k127_1015859_51 Acylphosphatase K01512 - 3.6.1.7 0.0000000000007269 76.0
TLS2_k127_1015859_52 - - - - 0.0000004473 61.0
TLS2_k127_1015859_53 Tetratricopeptide repeat - - - 0.0000351 54.0
TLS2_k127_1015859_54 - - - - 0.00005834 50.0
TLS2_k127_1015859_6 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 587.0
TLS2_k127_1015859_7 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 509.0
TLS2_k127_1015859_8 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 484.0
TLS2_k127_1015859_9 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 479.0
TLS2_k127_1020212_0 Atp-dependent helicase - - - 2.478e-300 942.0
TLS2_k127_1020212_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005947 443.0
TLS2_k127_1020212_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 347.0
TLS2_k127_1020212_3 Thioredoxin - - - 0.0000000000000000000000000000000000000002593 158.0
TLS2_k127_1020212_4 COG0720 6-pyruvoyl-tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000458 127.0
TLS2_k127_1020212_5 Transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.000000000000000000000000001047 115.0
TLS2_k127_1020212_6 Rdx family K07401 - - 0.0000000098 58.0
TLS2_k127_1023224_0 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 1.392e-258 819.0
TLS2_k127_1023224_1 Protein kinase domain K12132 - 2.7.11.1 9.369e-228 745.0
TLS2_k127_1023224_10 Sigma-70, region 4 type 2 - - - 0.00000000000000000000000000000033 132.0
TLS2_k127_1023224_11 Histidine kinase - - - 0.000000000000000000000000002755 126.0
TLS2_k127_1023224_12 - - - - 0.00000000000000000001993 95.0
TLS2_k127_1023224_13 InterPro IPR007367 - - - 0.0000000000000000000265 95.0
TLS2_k127_1023224_14 - - - - 0.000000000001157 74.0
TLS2_k127_1023224_15 TonB-dependent receptor K02014 - - 0.0000003532 62.0
TLS2_k127_1023224_16 YceI-like domain - - - 0.000003649 57.0
TLS2_k127_1023224_17 Carboxypeptidase regulatory-like domain - - - 0.00001684 56.0
TLS2_k127_1023224_2 GMC oxidoreductase K00108 - 1.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 489.0
TLS2_k127_1023224_3 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 455.0
TLS2_k127_1023224_4 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 389.0
TLS2_k127_1023224_5 PspA/IM30 family K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002339 269.0
TLS2_k127_1023224_6 Protein of unknown function (DUF1524) - - - 0.000000000000000000000000000000000000000000000003595 187.0
TLS2_k127_1023224_7 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000002727 175.0
TLS2_k127_1023224_8 Putative restriction endonuclease - - - 0.000000000000000000000000000000000003421 146.0
TLS2_k127_1023224_9 - - - - 0.00000000000000000000000000000001277 131.0
TLS2_k127_1038483_0 Protein related to penicillin acylase K01434 - 3.5.1.11 6.631e-264 836.0
TLS2_k127_1038483_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 607.0
TLS2_k127_1038483_10 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000001646 135.0
TLS2_k127_1038483_11 Clp amino terminal domain, pathogenicity island component K03696 - - 0.0000000000000000000000000000000001938 139.0
TLS2_k127_1038483_12 Membrane-bound lysozyme-inhibitor of c-type lysozyme K09914 - - 0.00000000000000000000009328 109.0
TLS2_k127_1038483_13 response to heat K03668 - - 0.000000000004315 72.0
TLS2_k127_1038483_14 positive regulation of growth - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00009176 48.0
TLS2_k127_1038483_2 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 576.0
TLS2_k127_1038483_3 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 481.0
TLS2_k127_1038483_4 Saccharopine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 388.0
TLS2_k127_1038483_5 Activator of Hsp90 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000002015 224.0
TLS2_k127_1038483_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000119 193.0
TLS2_k127_1038483_7 Protein of unknown function (DUF998) - - - 0.00000000000000000000000000000000000000000000000000001304 196.0
TLS2_k127_1038483_8 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000006657 182.0
TLS2_k127_1038483_9 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000002284 162.0
TLS2_k127_1097850_0 ABC transporter K06158 - - 3.983e-195 630.0
TLS2_k127_1097850_1 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 426.0
TLS2_k127_1097850_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 421.0
TLS2_k127_1097850_3 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 415.0
TLS2_k127_1097850_4 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002348 285.0
TLS2_k127_1097850_5 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000001406 225.0
TLS2_k127_1097850_6 ArsC family - - - 0.0000000000000000000000000000000000000000000008676 167.0
TLS2_k127_1097850_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000002163 141.0
TLS2_k127_1097850_8 positive regulation of type IV pilus biogenesis K07343 - - 0.0000000000000000000000003117 119.0
TLS2_k127_11086_0 CarboxypepD_reg-like domain - - - 0.0 1202.0
TLS2_k127_11086_1 Pfam:SusD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 580.0
TLS2_k127_11086_10 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 392.0
TLS2_k127_11086_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006405 381.0
TLS2_k127_11086_12 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 379.0
TLS2_k127_11086_13 Belongs to the glycosyl hydrolase 26 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 362.0
TLS2_k127_11086_14 Pfam Ion transport protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 319.0
TLS2_k127_11086_15 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007038 297.0
TLS2_k127_11086_16 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006928 286.0
TLS2_k127_11086_17 cell adhesion involved in biofilm formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001843 257.0
TLS2_k127_11086_18 protein conserved in bacteria K09797 - - 0.00000000000000000000000000000000000000000000000000000000000000000000534 241.0
TLS2_k127_11086_19 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000001951 229.0
TLS2_k127_11086_2 Cellulose synthase K00694 - 2.4.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 574.0
TLS2_k127_11086_20 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000001313 220.0
TLS2_k127_11086_21 - - - - 0.00000000000000000000000000000000000000000000000000000000009073 209.0
TLS2_k127_11086_22 Subtilase family - - - 0.000000000000000000000000000000000000000000000000008213 189.0
TLS2_k127_11086_24 Quinohemoprotein amine dehydrogenase, gamma subunit - - - 0.000000000000000000000000000000000000000000008194 168.0
TLS2_k127_11086_25 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0000000000000000000000000000000000000000001272 169.0
TLS2_k127_11086_26 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000003379 175.0
TLS2_k127_11086_27 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000000000000000000008238 163.0
TLS2_k127_11086_28 - - - - 0.000000000000000000000000000000000018 143.0
TLS2_k127_11086_29 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000008359 152.0
TLS2_k127_11086_3 4Fe-4S single cluster domain K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 494.0
TLS2_k127_11086_30 Tryptophan halogenase K16033 - - 0.00000000000000000000000000008505 132.0
TLS2_k127_11086_31 PFAM Transposase IS200 like - - - 0.0000000000000000000000002434 112.0
TLS2_k127_11086_32 Transcriptional regulator PadR-like family - - - 0.000000000000000000001472 102.0
TLS2_k127_11086_34 CarboxypepD_reg-like domain - - - 0.000000000000009557 87.0
TLS2_k127_11086_35 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000005721 83.0
TLS2_k127_11086_36 amine dehydrogenase activity - - - 0.000000000008565 72.0
TLS2_k127_11086_38 NHL repeat - - - 0.0000007562 61.0
TLS2_k127_11086_39 NHL repeat containing protein - - - 0.0000139 57.0
TLS2_k127_11086_4 dehydrogenases and related proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005946 471.0
TLS2_k127_11086_5 Type I phosphodiesterase / nucleotide pyrophosphatase K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 463.0
TLS2_k127_11086_6 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 469.0
TLS2_k127_11086_7 5'-nucleotidase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 464.0
TLS2_k127_11086_8 ASPIC UnbV domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 460.0
TLS2_k127_11086_9 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV K08685 - 1.4.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 445.0
TLS2_k127_115629_0 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 301.0
TLS2_k127_115629_1 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001014 256.0
TLS2_k127_115629_2 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000007604 189.0
TLS2_k127_115629_3 Peptidase family M23 - - - 0.000000002705 58.0
TLS2_k127_1166612_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 451.0
TLS2_k127_1166612_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 309.0
TLS2_k127_1166612_10 PASTA - - - 0.000000000000000006429 94.0
TLS2_k127_1166612_11 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000002126 80.0
TLS2_k127_1166612_12 COG0526 Thiol-disulfide isomerase and thioredoxins K02199 - - 0.0009008 48.0
TLS2_k127_1166612_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 303.0
TLS2_k127_1166612_3 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 312.0
TLS2_k127_1166612_4 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004058 263.0
TLS2_k127_1166612_5 PIN domain - - - 0.00000000000000000000000000000000000000000000000000000297 197.0
TLS2_k127_1166612_6 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000001355 158.0
TLS2_k127_1166612_7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000162 116.0
TLS2_k127_1166612_8 Preprotein translocase subunit K03210 - - 0.000000000000000000008517 95.0
TLS2_k127_1166612_9 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000008285 93.0
TLS2_k127_1175069_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 0.0 1048.0
TLS2_k127_1175069_1 cytochrome c oxidase subunit II K02275 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008226 463.0
TLS2_k127_1175069_2 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000002843 212.0
TLS2_k127_1175069_3 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000001651 178.0
TLS2_k127_1175069_4 This protein is involved in the repair of mismatches in DNA K03555 - - 0.00000000004451 64.0
TLS2_k127_1220482_0 Reverse transcriptase (RNA-dependent DNA polymerase) K00986,K15342 - 2.7.7.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008327 503.0
TLS2_k127_1220482_1 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.00000000001512 67.0
TLS2_k127_1242330_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0 1032.0
TLS2_k127_1242330_1 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007812 357.0
TLS2_k127_1242330_2 PFAM ThiJ PfpI K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000003794 218.0
TLS2_k127_1242330_3 Mazg nucleotide pyrophosphohydrolase K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000009308 163.0
TLS2_k127_1242330_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000001307 114.0
TLS2_k127_1242330_5 - - - - 0.000000001202 66.0
TLS2_k127_1287263_0 Chain length determinant protein K16554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 567.0
TLS2_k127_1287263_1 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008197 494.0
TLS2_k127_1287263_10 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000007028 187.0
TLS2_k127_1287263_11 GGDEF domain - - - 0.0000000000000001855 90.0
TLS2_k127_1287263_12 O-Antigen ligase - - - 0.000000000000001866 89.0
TLS2_k127_1287263_13 polysaccharide export - - - 0.0000000000004513 79.0
TLS2_k127_1287263_14 UDP-glucose/GDP-mannose dehydrogenase family, central domain - - - 0.00000001777 63.0
TLS2_k127_1287263_15 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K13010 - 2.6.1.102 0.00000003292 60.0
TLS2_k127_1287263_17 - - - - 0.0006326 49.0
TLS2_k127_1287263_18 - - - - 0.000888 49.0
TLS2_k127_1287263_2 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 346.0
TLS2_k127_1287263_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000197 273.0
TLS2_k127_1287263_4 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001164 256.0
TLS2_k127_1287263_5 Polysaccharide biosynthesis protein K03328 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004003 263.0
TLS2_k127_1287263_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001358 241.0
TLS2_k127_1287263_7 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000003408 226.0
TLS2_k127_1287263_8 Protein of unknown function (DUF3485) - - - 0.0000000000000000000000000000000000000000000000000000000001211 213.0
TLS2_k127_1287263_9 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000002454 198.0
TLS2_k127_1309003_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000001356 228.0
TLS2_k127_1309003_1 PIN domain - - - 0.000000000000000000000000000000000000002665 151.0
TLS2_k127_1309003_2 sequence-specific DNA binding - - - 0.0000000000000000000000000000008181 125.0
TLS2_k127_1309003_3 SpoVT / AbrB like domain - - - 0.00000000000000000001215 100.0
TLS2_k127_138154_0 B12 binding domain K00548 - 2.1.1.13 0.0 1723.0
TLS2_k127_138154_1 Glutamine synthetase type III K01915 - 6.3.1.2 1.81e-266 840.0
TLS2_k127_138154_10 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000082 269.0
TLS2_k127_138154_11 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007747 251.0
TLS2_k127_138154_12 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000002602 241.0
TLS2_k127_138154_13 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000007547 199.0
TLS2_k127_138154_14 Dihydrofolate reductase K00287,K18590 GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363 1.5.1.3 0.0000000000000000000000000000000000000000000002039 173.0
TLS2_k127_138154_15 Domain of unknown function (DUF3597) - - - 0.000000000000000000000000000000000000000000002279 169.0
TLS2_k127_138154_16 Erythromycin esterase K06880 - - 0.00000000000000000000000000000000000000000003432 185.0
TLS2_k127_138154_17 Trypsin-like serine protease - - - 0.0000000000000000000000000000000000005194 150.0
TLS2_k127_138154_18 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000000000001597 134.0
TLS2_k127_138154_19 YGGT family K02221 - - 0.000000000000000000000000000000001911 137.0
TLS2_k127_138154_2 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 2.692e-240 764.0
TLS2_k127_138154_20 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000001646 121.0
TLS2_k127_138154_21 ketosteroid isomerase - - - 0.000000000000000000000000007966 124.0
TLS2_k127_138154_22 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000008177 108.0
TLS2_k127_138154_23 - - - - 0.0000000000000000000003775 110.0
TLS2_k127_138154_24 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000008665 100.0
TLS2_k127_138154_25 Belongs to the UPF0235 family K09131 - - 0.000000000000000000001817 107.0
TLS2_k127_138154_26 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000002045 93.0
TLS2_k127_138154_27 D-Ala-D-Ala carboxypeptidase 3 (S13) family - - - 0.000000000000008598 88.0
TLS2_k127_138154_29 Heavy-metal-associated domain K07213 - - 0.0000000001072 70.0
TLS2_k127_138154_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 512.0
TLS2_k127_138154_30 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000004429 73.0
TLS2_k127_138154_31 Peptidase family S41 - - - 0.000000001169 69.0
TLS2_k127_138154_32 BFD-like [2Fe-2S] binding domain - - - 0.000000002859 66.0
TLS2_k127_138154_34 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00001102 49.0
TLS2_k127_138154_35 FR47-like protein K03789 - 2.3.1.128 0.0001 51.0
TLS2_k127_138154_36 Serine threonine protein kinase K12132 - 2.7.11.1 0.0002221 53.0
TLS2_k127_138154_4 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009827 438.0
TLS2_k127_138154_5 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 452.0
TLS2_k127_138154_6 COG1899 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 391.0
TLS2_k127_138154_7 Threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 378.0
TLS2_k127_138154_8 FAD linked oxidases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 370.0
TLS2_k127_138154_9 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 301.0
TLS2_k127_1382501_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 572.0
TLS2_k127_1382501_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 497.0
TLS2_k127_1382501_10 Na H antiporter, MnhB K05566 - - 0.000000000000000000000000006893 118.0
TLS2_k127_1382501_11 Na H antiporter K05566 - - 0.00000000000000000000000003674 113.0
TLS2_k127_1382501_12 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.0000000000000000004014 92.0
TLS2_k127_1382501_13 Na+/H+ ion antiporter subunit K05569 - - 0.000000000000001184 85.0
TLS2_k127_1382501_14 Na+/H+ antiporter subunit K05571 - - 0.000000000000001831 83.0
TLS2_k127_1382501_15 PFAM multiple resistance and pH regulation protein F K05570 - - 0.0000000003981 65.0
TLS2_k127_1382501_2 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008944 449.0
TLS2_k127_1382501_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 388.0
TLS2_k127_1382501_4 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 387.0
TLS2_k127_1382501_5 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 341.0
TLS2_k127_1382501_6 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007354 284.0
TLS2_k127_1382501_7 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000004421 224.0
TLS2_k127_1382501_8 Glycolate oxidase subunit GlcE K11472 - - 0.000000000000000000000000000000000000000001736 171.0
TLS2_k127_1382501_9 4Fe-4S binding domain K11473 - - 0.00000000000000000000000000000000000001029 153.0
TLS2_k127_1387005_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 3.141e-211 662.0
TLS2_k127_1387005_1 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 360.0
TLS2_k127_1387005_2 -O-antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003162 267.0
TLS2_k127_1387005_3 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000004166 144.0
TLS2_k127_1387005_4 - - - - 0.0000000000000000000000000000000001857 136.0
TLS2_k127_1387005_5 - - - - 0.00000000000000000000000000000132 128.0
TLS2_k127_1413620_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1535.0
TLS2_k127_1413620_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1230.0
TLS2_k127_1413620_10 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 501.0
TLS2_k127_1413620_11 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 495.0
TLS2_k127_1413620_12 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004917 453.0
TLS2_k127_1413620_13 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 454.0
TLS2_k127_1413620_14 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 446.0
TLS2_k127_1413620_15 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 449.0
TLS2_k127_1413620_16 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 434.0
TLS2_k127_1413620_17 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 434.0
TLS2_k127_1413620_18 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 426.0
TLS2_k127_1413620_19 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 399.0
TLS2_k127_1413620_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.187e-304 946.0
TLS2_k127_1413620_20 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 385.0
TLS2_k127_1413620_21 Belongs to the aldehyde dehydrogenase family K10217 - 1.2.1.32,1.2.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 359.0
TLS2_k127_1413620_22 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 350.0
TLS2_k127_1413620_23 Transcriptional regulatory protein, C terminal K02483,K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 324.0
TLS2_k127_1413620_24 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 329.0
TLS2_k127_1413620_25 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 316.0
TLS2_k127_1413620_26 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 310.0
TLS2_k127_1413620_27 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005081 304.0
TLS2_k127_1413620_28 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 301.0
TLS2_k127_1413620_29 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 295.0
TLS2_k127_1413620_3 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.379e-284 895.0
TLS2_k127_1413620_30 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 287.0
TLS2_k127_1413620_31 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 285.0
TLS2_k127_1413620_32 CYTH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001135 295.0
TLS2_k127_1413620_33 O-acyltransferase activity K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002701 278.0
TLS2_k127_1413620_34 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008133 288.0
TLS2_k127_1413620_35 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001778 285.0
TLS2_k127_1413620_36 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001869 268.0
TLS2_k127_1413620_37 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000006522 255.0
TLS2_k127_1413620_38 transferase activity, transferring acyl groups other than amino-acyl groups K11941 - - 0.00000000000000000000000000000000000000000000000000000000000000000004379 249.0
TLS2_k127_1413620_39 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000001841 221.0
TLS2_k127_1413620_4 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 1.61e-208 656.0
TLS2_k127_1413620_40 cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000002901 223.0
TLS2_k127_1413620_41 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000209 218.0
TLS2_k127_1413620_42 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.00000000000000000000000000000000000000000000000000000000003449 216.0
TLS2_k127_1413620_43 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000000001359 205.0
TLS2_k127_1413620_44 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000000002725 202.0
TLS2_k127_1413620_45 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000000000000000000387 194.0
TLS2_k127_1413620_46 - - - - 0.000000000000000000000000000000000000000000000000000005569 199.0
TLS2_k127_1413620_47 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000003116 202.0
TLS2_k127_1413620_48 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000005575 192.0
TLS2_k127_1413620_49 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000001059 194.0
TLS2_k127_1413620_5 Fumarase C C-terminus K01744 - 4.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 614.0
TLS2_k127_1413620_50 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000001347 181.0
TLS2_k127_1413620_51 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000002167 183.0
TLS2_k127_1413620_52 EVE domain - - - 0.0000000000000000000000000000000000000000000007078 169.0
TLS2_k127_1413620_53 - - - - 0.000000000000000000000000000000000000000000006442 171.0
TLS2_k127_1413620_54 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.00000000000000000000000000000000000000000006783 168.0
TLS2_k127_1413620_55 BadF/BadG/BcrA/BcrD ATPase family K18676 - 2.7.1.8 0.00000000000000000000000000000000000000000007646 176.0
TLS2_k127_1413620_56 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000000000000000000000000000000000001581 156.0
TLS2_k127_1413620_57 Iron-sulphur cluster biosynthesis - - - 0.0000000000000000000000000000000000000003109 153.0
TLS2_k127_1413620_58 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000005461 155.0
TLS2_k127_1413620_59 OmpA family K03640 - - 0.000000000000000000000000000000000001566 145.0
TLS2_k127_1413620_6 UDP binding domain K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 586.0
TLS2_k127_1413620_60 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000006005 144.0
TLS2_k127_1413620_61 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000001631 148.0
TLS2_k127_1413620_62 - - - - 0.000000000000000000000000000000007234 134.0
TLS2_k127_1413620_63 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000000000000003914 133.0
TLS2_k127_1413620_64 Outer membrane lipoprotein K05807 - - 0.00000000000000000000000000000007385 136.0
TLS2_k127_1413620_65 Tetratricopeptide repeat - - - 0.00000000000000000000000000009173 126.0
TLS2_k127_1413620_66 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925,K07102 - 2.7.1.221 0.000000000000000000000000006225 118.0
TLS2_k127_1413620_67 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000268 113.0
TLS2_k127_1413620_68 TonB C terminal K03832 - - 0.00000000000000000000000002772 119.0
TLS2_k127_1413620_69 Ribosomal-protein-alanine acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.000000000000000000000000327 111.0
TLS2_k127_1413620_7 UDP binding domain K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 567.0
TLS2_k127_1413620_70 LysM domain - - - 0.0000000000000000000006452 109.0
TLS2_k127_1413620_71 Glycoprotease family K14742 - - 0.000000000000000000002988 103.0
TLS2_k127_1413620_72 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000003039 93.0
TLS2_k127_1413620_73 Cupin 2, conserved barrel domain protein - - - 0.000000000000000283 93.0
TLS2_k127_1413620_74 Ribosomal protein L36 K02919 - - 0.000000000000002751 75.0
TLS2_k127_1413620_75 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840 - 0.0000000001116 72.0
TLS2_k127_1413620_8 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 503.0
TLS2_k127_1413620_9 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 501.0
TLS2_k127_1435879_0 ABC-type Fe3 transport system permease component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009785 427.0
TLS2_k127_1435879_1 TOBE domain K02010,K02017,K10112,K11072,K11076 - 3.6.3.29,3.6.3.30,3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 381.0
TLS2_k127_1435879_2 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 347.0
TLS2_k127_1435879_3 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000009865 256.0
TLS2_k127_1435879_4 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000003017 175.0
TLS2_k127_1435879_5 ECF sigma factor - - - 0.0000000000000000000000000000000003106 140.0
TLS2_k127_1468346_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1159.0
TLS2_k127_1468346_1 Cation transporting ATPase, C-terminus - - - 3.623e-304 957.0
TLS2_k127_1468346_10 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 469.0
TLS2_k127_1468346_11 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 461.0
TLS2_k127_1468346_12 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 449.0
TLS2_k127_1468346_13 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 436.0
TLS2_k127_1468346_14 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006265 407.0
TLS2_k127_1468346_15 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008995 392.0
TLS2_k127_1468346_16 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009749 394.0
TLS2_k127_1468346_17 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 389.0
TLS2_k127_1468346_18 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 387.0
TLS2_k127_1468346_19 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 371.0
TLS2_k127_1468346_2 Elongation factor G C-terminus K06207 - - 5.243e-286 893.0
TLS2_k127_1468346_20 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003103 336.0
TLS2_k127_1468346_21 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 329.0
TLS2_k127_1468346_22 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 333.0
TLS2_k127_1468346_23 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 321.0
TLS2_k127_1468346_24 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009988 315.0
TLS2_k127_1468346_25 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 304.0
TLS2_k127_1468346_26 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 293.0
TLS2_k127_1468346_27 UbiA prenyltransferase family K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 295.0
TLS2_k127_1468346_28 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007631 284.0
TLS2_k127_1468346_29 DNA-directed DNA polymerase activity K02347,K03581,K04477 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003541 285.0
TLS2_k127_1468346_3 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 4.586e-283 899.0
TLS2_k127_1468346_30 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004671 285.0
TLS2_k127_1468346_31 ABC transporter K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001972 265.0
TLS2_k127_1468346_32 Transglycosylase SLT domain K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003865 280.0
TLS2_k127_1468346_33 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004982 267.0
TLS2_k127_1468346_34 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000003204 274.0
TLS2_k127_1468346_35 Part of the ABC transporter FtsEX involved in K09811 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002515 256.0
TLS2_k127_1468346_36 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006828 258.0
TLS2_k127_1468346_37 Cation efflux family K16264 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.00000000000000000000000000000000000000000000000000000000000000000000005713 253.0
TLS2_k127_1468346_38 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000003041 245.0
TLS2_k127_1468346_39 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000002013 241.0
TLS2_k127_1468346_4 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.4e-247 777.0
TLS2_k127_1468346_40 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000001441 231.0
TLS2_k127_1468346_41 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000001135 229.0
TLS2_k127_1468346_42 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000002117 210.0
TLS2_k127_1468346_43 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000001602 203.0
TLS2_k127_1468346_44 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000000004049 201.0
TLS2_k127_1468346_45 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000001415 204.0
TLS2_k127_1468346_46 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000002058 210.0
TLS2_k127_1468346_47 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000006193 182.0
TLS2_k127_1468346_48 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000007474 171.0
TLS2_k127_1468346_49 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000001522 162.0
TLS2_k127_1468346_5 Peptidase family M1 domain K01256 - 3.4.11.2 6.087e-239 769.0
TLS2_k127_1468346_50 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000169 144.0
TLS2_k127_1468346_51 YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the K09780 - - 0.00000000000000000000000000000000001924 142.0
TLS2_k127_1468346_52 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000006388 147.0
TLS2_k127_1468346_53 - - - - 0.00000000000000000000000000001227 125.0
TLS2_k127_1468346_54 Ribosomal protein S16 K02959 - - 0.000000000000000000000111 100.0
TLS2_k127_1468346_55 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000002735 102.0
TLS2_k127_1468346_56 integral membrane protein K07027 - - 0.000000000000000000006765 105.0
TLS2_k127_1468346_57 - - - - 0.00000000000000000001446 104.0
TLS2_k127_1468346_58 Protein of unknown function (DUF445) - - - 0.000000000000000003723 99.0
TLS2_k127_1468346_59 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000002784 89.0
TLS2_k127_1468346_6 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.097e-228 748.0
TLS2_k127_1468346_60 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000153 83.0
TLS2_k127_1468346_61 protein conserved in bacteria K09796 - - 0.0000000000006127 77.0
TLS2_k127_1468346_62 - - - - 0.00000000006702 68.0
TLS2_k127_1468346_63 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000001517 67.0
TLS2_k127_1468346_64 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.0000000004236 73.0
TLS2_k127_1468346_65 - - - - 0.0000000264 63.0
TLS2_k127_1468346_66 - - - - 0.0000007245 51.0
TLS2_k127_1468346_67 ABC-type multidrug transport system ATPase component - - - 0.0001 52.0
TLS2_k127_1468346_68 hydrolase of the HAD superfamily K07015 - - 0.0007705 50.0
TLS2_k127_1468346_7 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 6.671e-222 701.0
TLS2_k127_1468346_8 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 578.0
TLS2_k127_1468346_9 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009662 535.0
TLS2_k127_1470661_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0 1060.0
TLS2_k127_1470661_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.977e-294 916.0
TLS2_k127_1470661_10 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004679 507.0
TLS2_k127_1470661_11 Cell cycle protein K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 459.0
TLS2_k127_1470661_12 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 434.0
TLS2_k127_1470661_13 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 444.0
TLS2_k127_1470661_14 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 445.0
TLS2_k127_1470661_15 ATP-grasp domain K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 439.0
TLS2_k127_1470661_16 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 419.0
TLS2_k127_1470661_17 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 424.0
TLS2_k127_1470661_18 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 417.0
TLS2_k127_1470661_19 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 377.0
TLS2_k127_1470661_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 3.449e-266 841.0
TLS2_k127_1470661_20 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 373.0
TLS2_k127_1470661_21 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 380.0
TLS2_k127_1470661_22 Hypothetical methyltransferase K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 371.0
TLS2_k127_1470661_23 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 364.0
TLS2_k127_1470661_24 Ribosomal protein S2 K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 353.0
TLS2_k127_1470661_25 Trypsin K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 375.0
TLS2_k127_1470661_26 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 329.0
TLS2_k127_1470661_27 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 336.0
TLS2_k127_1470661_28 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 315.0
TLS2_k127_1470661_29 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 327.0
TLS2_k127_1470661_3 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 3.48e-232 734.0
TLS2_k127_1470661_30 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015,K00050,K00090 - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 310.0
TLS2_k127_1470661_31 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 306.0
TLS2_k127_1470661_32 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 295.0
TLS2_k127_1470661_33 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000008287 269.0
TLS2_k127_1470661_34 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004731 270.0
TLS2_k127_1470661_35 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000162 256.0
TLS2_k127_1470661_36 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003979 257.0
TLS2_k127_1470661_37 PFAM CorA-like Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001392 253.0
TLS2_k127_1470661_38 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000004573 261.0
TLS2_k127_1470661_39 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000003216 250.0
TLS2_k127_1470661_4 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.262e-224 707.0
TLS2_k127_1470661_40 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000111 240.0
TLS2_k127_1470661_41 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000001354 229.0
TLS2_k127_1470661_42 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000002117 221.0
TLS2_k127_1470661_43 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000002528 217.0
TLS2_k127_1470661_44 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000002838 197.0
TLS2_k127_1470661_45 glucose-methanol-choline oxidoreductase K20927,K21166 - 1.1.1.400 0.00000000000000000000000000000000000000000000000000000188 210.0
TLS2_k127_1470661_46 Ribosomal protein S9/S16 K02996 - - 0.0000000000000000000000000000000000000000000000000002344 188.0
TLS2_k127_1470661_47 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000003232 195.0
TLS2_k127_1470661_48 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000001186 186.0
TLS2_k127_1470661_49 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000006145 197.0
TLS2_k127_1470661_5 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 1.023e-201 640.0
TLS2_k127_1470661_50 NmrA-like family - - - 0.000000000000000000000000000000000000000000442 168.0
TLS2_k127_1470661_51 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000000000002583 159.0
TLS2_k127_1470661_52 rod shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000000005563 158.0
TLS2_k127_1470661_53 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.0000000000000000000000000000007466 128.0
TLS2_k127_1470661_54 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000003027 128.0
TLS2_k127_1470661_55 diguanylate cyclase - - - 0.000000000000000000000000000006988 136.0
TLS2_k127_1470661_56 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000002343 121.0
TLS2_k127_1470661_57 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.0000000000000000000000000001616 128.0
TLS2_k127_1470661_58 rod shape-determining protein MreD K03571 - - 0.000000000000000000000000004256 118.0
TLS2_k127_1470661_59 Cache 3/Cache 2 fusion domain - - - 0.00000000000000000008421 105.0
TLS2_k127_1470661_6 Hsp70 protein K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 599.0
TLS2_k127_1470661_60 Transcription factor zinc-finger K09981 - - 0.0000000000000000001822 91.0
TLS2_k127_1470661_61 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000003253 94.0
TLS2_k127_1470661_63 LytR cell envelope-related transcriptional attenuator - - - 0.0000000001748 70.0
TLS2_k127_1470661_64 amine dehydrogenase activity - - - 0.000000641 61.0
TLS2_k127_1470661_66 TonB-dependent receptor - - - 0.000008327 57.0
TLS2_k127_1470661_7 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 570.0
TLS2_k127_1470661_8 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 555.0
TLS2_k127_1470661_9 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 541.0
TLS2_k127_1487481_0 WD40 domain protein beta Propeller - - - 0.00000000000000000000000000000000009979 153.0
TLS2_k127_1487481_1 cAMP biosynthetic process - - - 0.000000000000001244 80.0
TLS2_k127_150962_0 metallocarboxypeptidase activity K14054 - - 0.0 1076.0
TLS2_k127_150962_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 7.92e-293 912.0
TLS2_k127_150962_10 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 607.0
TLS2_k127_150962_11 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 605.0
TLS2_k127_150962_12 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003582 537.0
TLS2_k127_150962_13 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 519.0
TLS2_k127_150962_14 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 503.0
TLS2_k127_150962_15 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 501.0
TLS2_k127_150962_16 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 498.0
TLS2_k127_150962_17 Domain of unknown function (DUF3536) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 481.0
TLS2_k127_150962_18 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 435.0
TLS2_k127_150962_19 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000065 438.0
TLS2_k127_150962_2 Carbohydrate phosphorylase K00688 - 2.4.1.1 5.337e-292 916.0
TLS2_k127_150962_20 HI0933-like protein K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 415.0
TLS2_k127_150962_21 antibiotic catabolic process K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008098 411.0
TLS2_k127_150962_22 Belongs to the glycosyl hydrolase 57 family K03406,K16149 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009416 409.0
TLS2_k127_150962_23 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 382.0
TLS2_k127_150962_24 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 373.0
TLS2_k127_150962_25 mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 361.0
TLS2_k127_150962_26 Mechanosensitive ion channel K05802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 331.0
TLS2_k127_150962_27 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 321.0
TLS2_k127_150962_28 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 309.0
TLS2_k127_150962_29 - - - - 0.0000000000000000000000000000000000000000000000000000000000000398 226.0
TLS2_k127_150962_3 Glycosyltransferase family 20 K03692 - 2.4.1.213 6.507e-263 829.0
TLS2_k127_150962_30 homoserine kinase K00872 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000008755 219.0
TLS2_k127_150962_31 Zn_pept - - - 0.0000000000000000000000000000000000000000002827 179.0
TLS2_k127_150962_32 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000007496 172.0
TLS2_k127_150962_33 - - - - 0.0000000000000000000000000000000000000003662 154.0
TLS2_k127_150962_34 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000002879 155.0
TLS2_k127_150962_35 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000001439 121.0
TLS2_k127_150962_36 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.0000000000000000000000000002454 123.0
TLS2_k127_150962_37 SCP-2 sterol transfer family - - - 0.00000000000000000000002825 104.0
TLS2_k127_150962_38 Redoxin - - - 0.000000000000000001529 89.0
TLS2_k127_150962_39 Membrane - - - 0.000000000000004812 83.0
TLS2_k127_150962_4 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 3.048e-255 799.0
TLS2_k127_150962_40 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000003748 81.0
TLS2_k127_150962_42 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000001723 55.0
TLS2_k127_150962_43 Redoxin - - - 0.0001727 48.0
TLS2_k127_150962_5 Sodium:solute symporter family - - - 4.513e-244 766.0
TLS2_k127_150962_6 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.635e-224 709.0
TLS2_k127_150962_7 lysine biosynthetic process via aminoadipic acid - - - 1.141e-218 708.0
TLS2_k127_150962_8 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 4.224e-203 646.0
TLS2_k127_150962_9 Sodium:sulfate symporter transmembrane region - - - 3.056e-198 637.0
TLS2_k127_1555228_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 4.768e-224 707.0
TLS2_k127_1555228_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 4.582e-210 661.0
TLS2_k127_1555228_2 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 342.0
TLS2_k127_1555228_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003074 278.0
TLS2_k127_1555228_4 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000001227 226.0
TLS2_k127_1555228_5 cytochrome c nitrite reductase K15876 - - 0.000000000000000000000000000000000000000000000000000000000006819 211.0
TLS2_k127_1555228_6 - - - - 0.0000000000000000000000000000000000000000000000000000000006181 205.0
TLS2_k127_1555228_7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000003554 196.0
TLS2_k127_1555228_8 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000104 158.0
TLS2_k127_1577913_0 Heat shock 70 kDa protein K04043 - - 1.354e-306 953.0
TLS2_k127_1577913_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 599.0
TLS2_k127_1577913_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004942 551.0
TLS2_k127_1577913_3 PFAM Protein kinase K03413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 478.0
TLS2_k127_1577913_4 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 359.0
TLS2_k127_1577913_5 Response regulator receiver K11443 - - 0.00000000000000000000000000000000000000000000000000001011 190.0
TLS2_k127_1577913_6 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000002111 180.0
TLS2_k127_1593042_0 PA14 domain K05349 - 3.2.1.21 1.597e-306 963.0
TLS2_k127_1593042_1 Insulinase (Peptidase family M16) K07263 - - 1.642e-247 794.0
TLS2_k127_1593042_10 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000001168 211.0
TLS2_k127_1593042_11 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000003547 208.0
TLS2_k127_1593042_12 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000007075 176.0
TLS2_k127_1593042_13 - - - - 0.00000000000000000000000000000000000000000000001106 175.0
TLS2_k127_1593042_14 DinB superfamily - - - 0.00000000000000000000000000000000000000000000005822 176.0
TLS2_k127_1593042_15 Chromatin associated protein KTI12 K07028 - - 0.0000000000000000000000000000000000000000000006359 174.0
TLS2_k127_1593042_16 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000002534 151.0
TLS2_k127_1593042_17 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000007781 154.0
TLS2_k127_1593042_18 ECF sigma factor K03088 - - 0.00000000000000000000000000000003055 138.0
TLS2_k127_1593042_19 protein conserved in bacteria K09790 - - 0.000000000000000000000000000008465 123.0
TLS2_k127_1593042_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0040007,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 1.322e-244 766.0
TLS2_k127_1593042_20 PEP-CTERM motif - - - 0.00000000000000000000000000007346 127.0
TLS2_k127_1593042_21 Protein of unknown function (DUF1579) - - - 0.0000000000000000000000002071 113.0
TLS2_k127_1593042_22 Exopolysaccharide synthesis, ExoD - - - 0.0000000000000000000006381 103.0
TLS2_k127_1593042_23 PEP-CTERM motif - - - 0.0000000000000000000006942 106.0
TLS2_k127_1593042_24 L-lysine 6-monooxygenase (NADPH-requiring) - - - 0.0000008675 60.0
TLS2_k127_1593042_25 Protein of unknown function, DUF481 K07283 - - 0.00002436 52.0
TLS2_k127_1593042_3 Peptidase dimerisation domain K12941 - - 4.304e-195 622.0
TLS2_k127_1593042_4 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 619.0
TLS2_k127_1593042_5 Domain of unknown function (DUF5118) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 624.0
TLS2_k127_1593042_6 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005414 498.0
TLS2_k127_1593042_7 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 467.0
TLS2_k127_1593042_8 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001638 289.0
TLS2_k127_1593042_9 tRNA wobble adenosine to inosine editing - - - 0.000000000000000000000000000000000000000000000000000000000000000002232 231.0
TLS2_k127_1637366_0 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 517.0
TLS2_k127_1637366_1 Ferritin-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 330.0
TLS2_k127_1682979_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000001157 223.0
TLS2_k127_1682979_1 Domain of unknown function (DUF4405) - - - 0.0000000000000000000000000003974 128.0
TLS2_k127_1682979_2 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.000000000000005922 79.0
TLS2_k127_169723_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000002515 181.0
TLS2_k127_169723_1 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000003533 183.0
TLS2_k127_169723_2 - - - - 0.00000000000000000000000000000000004051 139.0
TLS2_k127_169723_3 AAA domain - - - 0.000000000000000000000000000000000444 134.0
TLS2_k127_169723_4 NUDIX domain - - - 0.000000000000000000000000000005064 128.0
TLS2_k127_169723_5 Putative cyclase - - - 0.000000000000000001267 89.0
TLS2_k127_172187_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 367.0
TLS2_k127_172187_1 Drug exporters of the RND superfamily K06994,K07003,K20466,K20470 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 368.0
TLS2_k127_172187_10 Thioesterase K07107,K12500 - - 0.000000000000000000009001 106.0
TLS2_k127_172187_11 Protein conserved in bacteria - - - 0.000000000000001691 80.0
TLS2_k127_172187_12 - - - - 0.00000000002121 72.0
TLS2_k127_172187_2 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 340.0
TLS2_k127_172187_3 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001851 280.0
TLS2_k127_172187_4 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000135 255.0
TLS2_k127_172187_5 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000001821 196.0
TLS2_k127_172187_6 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000133 205.0
TLS2_k127_172187_7 HEAT repeats - - - 0.00000000000000000000000000000000000001252 164.0
TLS2_k127_172187_8 Iron-sulfur cluster assembly protein - - - 0.000000000000000000000000000005762 124.0
TLS2_k127_172187_9 Matrixin - - - 0.0000000000000000000006467 105.0
TLS2_k127_172258_0 - - - - 0.000000000000000000000000000000000000651 149.0
TLS2_k127_172258_1 - - - - 0.0000000000000000000000000000000005653 137.0
TLS2_k127_172258_2 Protein conserved in bacteria - - - 0.0000000000000000000001039 107.0
TLS2_k127_172258_3 guanyl-nucleotide exchange factor activity K14475,K20276 - - 0.00000001973 65.0
TLS2_k127_172258_4 PFAM NHL repeat containing protein - - - 0.00003086 51.0
TLS2_k127_172258_5 TIGRFAM TonB-dependent siderophore receptor K02014 - - 0.00008002 55.0
TLS2_k127_176787_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 0.0 1039.0
TLS2_k127_176787_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 2.343e-239 760.0
TLS2_k127_176787_10 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000002071 242.0
TLS2_k127_176787_11 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000008194 221.0
TLS2_k127_176787_12 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000273 156.0
TLS2_k127_176787_13 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000001736 157.0
TLS2_k127_176787_14 endonuclease activity - - - 0.000000000000000000000000000000009664 134.0
TLS2_k127_176787_15 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000031 130.0
TLS2_k127_176787_16 Tellurite resistance protein TehB - - - 0.000000000000000000126 103.0
TLS2_k127_176787_2 Enoyl-CoA hydratase/isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 4.531e-215 690.0
TLS2_k127_176787_3 Peptidase family M28 - - - 1.943e-199 636.0
TLS2_k127_176787_4 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 539.0
TLS2_k127_176787_5 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 498.0
TLS2_k127_176787_6 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 452.0
TLS2_k127_176787_7 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 360.0
TLS2_k127_176787_8 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 353.0
TLS2_k127_176787_9 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000586 242.0
TLS2_k127_180980_0 chloride channel K03281 - - 2.008e-201 643.0
TLS2_k127_180980_1 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 600.0
TLS2_k127_180980_10 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 338.0
TLS2_k127_180980_11 Multicopper oxidase K04753,K08100 - 1.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 343.0
TLS2_k127_180980_12 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 349.0
TLS2_k127_180980_13 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008746 318.0
TLS2_k127_180980_14 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 310.0
TLS2_k127_180980_15 Protein of unknown function (DUF819) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 296.0
TLS2_k127_180980_16 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 297.0
TLS2_k127_180980_17 Domain of unknown function (DUF4403) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002428 291.0
TLS2_k127_180980_18 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002232 282.0
TLS2_k127_180980_19 homoserine kinase activity K02204,K13059 - 2.7.1.162,2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003889 281.0
TLS2_k127_180980_2 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and K03182 - 4.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 569.0
TLS2_k127_180980_20 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001228 278.0
TLS2_k127_180980_21 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000003222 225.0
TLS2_k127_180980_22 nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000001321 201.0
TLS2_k127_180980_23 Cytochrome c K00376,K02305,K17760 - 1.1.9.1,1.7.2.4 0.0000000000000000000000000000000000000000000000006391 190.0
TLS2_k127_180980_24 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000004651 192.0
TLS2_k127_180980_25 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000003975 180.0
TLS2_k127_180980_26 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000001312 184.0
TLS2_k127_180980_27 Protein of unknown function (DUF1203) - - - 0.00000000000000000000000000000000000000000003627 168.0
TLS2_k127_180980_28 Peptidase family S41 - - - 0.00000000000000000000000000000000000000003342 171.0
TLS2_k127_180980_29 PFAM peptidase - - - 0.0000000000000000000000397 116.0
TLS2_k127_180980_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 529.0
TLS2_k127_180980_30 Photosynthetic reaction centre cytochrome C subunit - - - 0.0000000000000000000004427 103.0
TLS2_k127_180980_31 Cytochrome c - - - 0.000000000000008553 87.0
TLS2_k127_180980_4 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 550.0
TLS2_k127_180980_5 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 514.0
TLS2_k127_180980_6 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 508.0
TLS2_k127_180980_7 membrane K07148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 397.0
TLS2_k127_180980_8 Putative RNA methylase family UPF0020 K07444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 372.0
TLS2_k127_180980_9 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 378.0
TLS2_k127_1812669_0 cellulose binding - - - 0.0 1062.0
TLS2_k127_1812669_1 metallocarboxypeptidase activity K14054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 517.0
TLS2_k127_1880876_0 site-specific DNA-methyltransferase (adenine-specific) activity - - - 0.0 1150.0
TLS2_k127_1880876_1 Belongs to the peptidase S8 family K08651,K14645 - 3.4.21.66 3.533e-317 1008.0
TLS2_k127_1880876_10 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005807 289.0
TLS2_k127_1880876_11 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003209 273.0
TLS2_k127_1880876_12 Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000009075 220.0
TLS2_k127_1880876_13 COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000002391 188.0
TLS2_k127_1880876_14 - - - - 0.0000000000000000000000000000000000000000000004076 175.0
TLS2_k127_1880876_15 ABC transporter K02049,K10831,K15555 - 3.6.3.36 0.00000000000000000000000000000000000000000000544 174.0
TLS2_k127_1880876_16 MTH538 TIR-like domain (DUF1863) - - - 0.00000000000000000000000000000000000000001246 158.0
TLS2_k127_1880876_17 - - - - 0.000000000000000000000000000000000006334 151.0
TLS2_k127_1880876_19 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000009166 132.0
TLS2_k127_1880876_2 - - - - 1.387e-213 672.0
TLS2_k127_1880876_20 response regulator - - - 0.00000000000000000000000000007752 125.0
TLS2_k127_1880876_21 Protein of unknown function (DUF4238) - - - 0.000000000000000000000000002456 124.0
TLS2_k127_1880876_22 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000001709 118.0
TLS2_k127_1880876_23 Belongs to the peptidase M12A family K08076 - 3.4.24.21 0.00000000000000000000002217 114.0
TLS2_k127_1880876_24 Astacin (Peptidase family M12A) - - - 0.000000000000006383 88.0
TLS2_k127_1880876_25 nuclear chromosome segregation - - - 0.0000000000001077 84.0
TLS2_k127_1880876_27 - - - - 0.0000001242 59.0
TLS2_k127_1880876_29 - - - - 0.00001312 54.0
TLS2_k127_1880876_3 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007802 589.0
TLS2_k127_1880876_30 - - - - 0.00007501 53.0
TLS2_k127_1880876_31 Domain of unknown function (DUF4934) - - - 0.0001245 54.0
TLS2_k127_1880876_32 Bor protein - - - 0.0002024 51.0
TLS2_k127_1880876_4 FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 445.0
TLS2_k127_1880876_5 Caspase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 369.0
TLS2_k127_1880876_6 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 353.0
TLS2_k127_1880876_7 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 342.0
TLS2_k127_1880876_9 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001933 286.0
TLS2_k127_1941892_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 5.031e-301 934.0
TLS2_k127_1941892_1 Sodium:solute symporter family - - - 9.243e-267 831.0
TLS2_k127_1941892_10 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 400.0
TLS2_k127_1941892_11 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 396.0
TLS2_k127_1941892_12 peptidase activity K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000875 385.0
TLS2_k127_1941892_13 Xylose isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 372.0
TLS2_k127_1941892_14 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004738 302.0
TLS2_k127_1941892_15 PFAM nucleoside H symporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001875 278.0
TLS2_k127_1941892_16 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001028 252.0
TLS2_k127_1941892_17 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008939 246.0
TLS2_k127_1941892_18 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001219 244.0
TLS2_k127_1941892_19 isomerase - - - 0.0000000000000000000000000000000000000000000000000000000004636 215.0
TLS2_k127_1941892_2 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.879e-229 724.0
TLS2_k127_1941892_20 - - - - 0.000000000000000000000000000000000000000000000000000000002131 207.0
TLS2_k127_1941892_21 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000001805 211.0
TLS2_k127_1941892_22 Leishmanolysin - - - 0.0000000000000000000000000000000000000000000000000009955 202.0
TLS2_k127_1941892_23 dehydrogenases and related proteins - - - 0.000000000000000000000000000000000000000000005623 181.0
TLS2_k127_1941892_24 - - - - 0.0000000000000000000000000000000000001618 151.0
TLS2_k127_1941892_25 - - - - 0.000000000000000000000000000000001254 145.0
TLS2_k127_1941892_26 protein flavinylation K03734 - 2.7.1.180 0.000000000000000000000000000000007849 143.0
TLS2_k127_1941892_27 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000006042 115.0
TLS2_k127_1941892_28 NHL repeat - - - 0.0000005826 61.0
TLS2_k127_1941892_29 pathogenesis - - - 0.0000009392 61.0
TLS2_k127_1941892_3 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 486.0
TLS2_k127_1941892_4 PFAM oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 486.0
TLS2_k127_1941892_5 AP endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007741 463.0
TLS2_k127_1941892_6 amine dehydrogenase activity K17285 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 439.0
TLS2_k127_1941892_7 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 453.0
TLS2_k127_1941892_8 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 430.0
TLS2_k127_1941892_9 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 418.0
TLS2_k127_1951794_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1182.0
TLS2_k127_1951794_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1150.0
TLS2_k127_1951794_10 WD40 repeats - - - 0.00002208 56.0
TLS2_k127_1951794_2 AcrB/AcrD/AcrF family K03296 - - 0.0 1025.0
TLS2_k127_1951794_3 diguanylate cyclase K02488 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 402.0
TLS2_k127_1951794_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 351.0
TLS2_k127_1951794_5 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000006851 271.0
TLS2_k127_1951794_6 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000001151 209.0
TLS2_k127_1951794_7 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000001657 189.0
TLS2_k127_1951794_8 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000002434 198.0
TLS2_k127_1951794_9 amine dehydrogenase activity - - - 0.000000000002446 79.0
TLS2_k127_1959228_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 2.351e-262 821.0
TLS2_k127_1959228_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 2.662e-237 769.0
TLS2_k127_1959228_10 - - - - 0.000000000000000000000000000000000000000000000003868 197.0
TLS2_k127_1959228_11 Zn_pept - - - 0.000000000000000000000000000000000000000000003241 185.0
TLS2_k127_1959228_12 glyoxalase III activity - - - 0.0000000000000000000000000000000000001153 152.0
TLS2_k127_1959228_13 PFAM PIN domain - - - 0.0000000000000000000000000002719 118.0
TLS2_k127_1959228_14 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000009324 97.0
TLS2_k127_1959228_15 - - - - 0.00000000000000000008891 93.0
TLS2_k127_1959228_16 amine dehydrogenase activity - - - 0.000000000001268 79.0
TLS2_k127_1959228_17 Sigma-70, region 4 K03088 - - 0.00000000004639 70.0
TLS2_k127_1959228_2 TrkA-N domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 602.0
TLS2_k127_1959228_3 MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 599.0
TLS2_k127_1959228_4 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 534.0
TLS2_k127_1959228_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 503.0
TLS2_k127_1959228_6 Multicopper oxidase K22348 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 475.0
TLS2_k127_1959228_7 PFAM thiamine pyrophosphate enzyme K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 417.0
TLS2_k127_1959228_8 Integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 297.0
TLS2_k127_1959228_9 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005443 274.0
TLS2_k127_2116127_0 nucleoside-diphosphate sugar epimerase K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 382.0
TLS2_k127_2116127_1 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000186 105.0
TLS2_k127_2180673_0 Tricorn protease homolog K08676 - - 0.0 1261.0
TLS2_k127_2180673_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004633 460.0
TLS2_k127_2180673_10 DinB superfamily - - - 0.00000000000000000000000000000000000000000000009708 176.0
TLS2_k127_2180673_11 Carbon-nitrogen hydrolase K01950 - 6.3.5.1 0.000000000000000000000000000000000000000004947 165.0
TLS2_k127_2180673_12 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000006167 153.0
TLS2_k127_2180673_13 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.0000000000000000000000000002229 122.0
TLS2_k127_2180673_14 COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000005713 120.0
TLS2_k127_2180673_15 Bacterial Ig-like domain 2 - - - 0.00007694 53.0
TLS2_k127_2180673_2 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 446.0
TLS2_k127_2180673_3 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 349.0
TLS2_k127_2180673_4 NAD dependent epimerase/dehydratase family - GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 337.0
TLS2_k127_2180673_5 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 330.0
TLS2_k127_2180673_6 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 291.0
TLS2_k127_2180673_7 transcriptional regulator K16137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002008 269.0
TLS2_k127_2180673_8 Belongs to the glycosyl hydrolase 43 family K01181 GO:0003674,GO:0003824,GO:0004553,GO:0016787,GO:0016798,GO:0031176,GO:0033905,GO:0097599 3.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000001375 282.0
TLS2_k127_2180673_9 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.00000000000000000000000000000000000000000000000000000000000002597 230.0
TLS2_k127_2209796_0 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 1.738e-258 803.0
TLS2_k127_2209796_1 E1-E2 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 545.0
TLS2_k127_2209796_10 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00004721 55.0
TLS2_k127_2209796_2 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K22110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 295.0
TLS2_k127_2209796_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000936 235.0
TLS2_k127_2209796_4 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000006191 229.0
TLS2_k127_2209796_5 Thioredoxin-like domain K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000005867 161.0
TLS2_k127_2209796_6 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000004905 168.0
TLS2_k127_2209796_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000001677 104.0
TLS2_k127_2209796_8 Glucose / Sorbosone dehydrogenase - - - 0.00000000000002429 79.0
TLS2_k127_2209796_9 Protein of unknown function (DUF2892) - - - 0.0000000003163 63.0
TLS2_k127_2216066_0 Transport of potassium into the cell K03549 - - 1.457e-256 806.0
TLS2_k127_2216066_1 Arginosuccinate synthase K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 419.0
TLS2_k127_2216066_10 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001069 261.0
TLS2_k127_2216066_11 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002382 254.0
TLS2_k127_2216066_12 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000005019 247.0
TLS2_k127_2216066_13 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000003353 222.0
TLS2_k127_2216066_14 HAD-hyrolase-like K06019 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000006572 215.0
TLS2_k127_2216066_15 AI-2E family transporter - - - 0.0000000000000000000000000000000000007616 157.0
TLS2_k127_2216066_16 SNF2 family N-terminal domain - - - 0.0000000000000000000000000000000003062 153.0
TLS2_k127_2216066_17 Belongs to the ompA family K03286 - - 0.00000000000000000000000006157 122.0
TLS2_k127_2216066_18 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000000003213 108.0
TLS2_k127_2216066_19 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.000000000000002631 85.0
TLS2_k127_2216066_2 DNA restriction-modification system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 432.0
TLS2_k127_2216066_3 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 365.0
TLS2_k127_2216066_4 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005938 354.0
TLS2_k127_2216066_5 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K00857,K01920,K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.21,6.3.2.3,6.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 347.0
TLS2_k127_2216066_6 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 323.0
TLS2_k127_2216066_7 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 317.0
TLS2_k127_2216066_8 Response regulator receiver K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 291.0
TLS2_k127_2216066_9 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000005304 265.0
TLS2_k127_2234280_0 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 2.765e-226 723.0
TLS2_k127_2234280_1 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 560.0
TLS2_k127_2234280_10 - - - - 0.0000000000000000000000000000000000000000001026 170.0
TLS2_k127_2234280_11 - - - - 0.000000000000000000000000000000000001138 149.0
TLS2_k127_2234280_2 COG1283 Na phosphate symporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 508.0
TLS2_k127_2234280_3 Peptidase family S58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 494.0
TLS2_k127_2234280_4 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 442.0
TLS2_k127_2234280_5 PFAM amino acid permease-associated region K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 398.0
TLS2_k127_2234280_6 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000000000000000000009793 203.0
TLS2_k127_2234280_7 - - - - 0.0000000000000000000000000000000000000000000000000000005278 215.0
TLS2_k127_2234280_8 Domain of unknown function (DUF4912) K02040 - - 0.00000000000000000000000000000000000000000000009788 182.0
TLS2_k127_2234280_9 domain protein - - - 0.00000000000000000000000000000000000000000002661 174.0
TLS2_k127_2288910_0 belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005748 355.0
TLS2_k127_2288910_1 Histidine kinase - - - 0.0000000000000000000000000000000000158 141.0
TLS2_k127_237621_0 DNA polymerase K02337 - 2.7.7.7 3.619e-298 953.0
TLS2_k127_237621_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.413e-241 752.0
TLS2_k127_237621_10 PSP1 C-terminal conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 321.0
TLS2_k127_237621_11 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002061 250.0
TLS2_k127_237621_12 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000274 225.0
TLS2_k127_237621_13 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000005007 208.0
TLS2_k127_237621_14 domain, Protein K01179,K07260,K13735 - 3.2.1.4,3.4.17.14 0.00000000000000000000000000000000000000000000000000000002883 218.0
TLS2_k127_237621_15 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000001365 197.0
TLS2_k127_237621_16 Peptidase family M23 - - - 0.00000000000000000000000000000000000000001367 164.0
TLS2_k127_237621_17 COG1651 Protein-disulfide isomerase K21990 - - 0.0000000000000000000000000000000000005836 147.0
TLS2_k127_237621_18 TPM domain K06872 - - 0.0000000000000000000001751 109.0
TLS2_k127_237621_19 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000002282 100.0
TLS2_k127_237621_2 tRNA synthetases class I (M) K01874 - 6.1.1.10 2.303e-195 621.0
TLS2_k127_237621_20 nucleotidyltransferase activity - - - 0.000000000000000000004551 105.0
TLS2_k127_237621_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 428.0
TLS2_k127_237621_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 410.0
TLS2_k127_237621_5 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 430.0
TLS2_k127_237621_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 412.0
TLS2_k127_237621_7 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009704 381.0
TLS2_k127_237621_8 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 350.0
TLS2_k127_237621_9 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 339.0
TLS2_k127_2499493_0 hydroperoxide reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004161 265.0
TLS2_k127_2499493_1 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007225 267.0
TLS2_k127_2499493_2 PFAM phospholipase Carboxylesterase - - - 0.000000000000000000000000000000000000000000000000000000000009402 216.0
TLS2_k127_2499493_3 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000000000000000001139 199.0
TLS2_k127_2529561_0 DALR_2 K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 468.0
TLS2_k127_2529561_1 mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000005718 236.0
TLS2_k127_2529561_2 PIN domain - - - 0.000000000000000000000000346 110.0
TLS2_k127_2529561_3 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000006016 86.0
TLS2_k127_2529561_4 - - - - 0.0000000203 56.0
TLS2_k127_2529561_5 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000003353 60.0
TLS2_k127_2529561_6 - - - - 0.0003507 45.0
TLS2_k127_268207_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 582.0
TLS2_k127_268207_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006147 552.0
TLS2_k127_268207_10 - - - - 0.0000000004038 68.0
TLS2_k127_268207_11 Pilus assembly protein, PilO K02664 - - 0.0000005568 59.0
TLS2_k127_268207_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 508.0
TLS2_k127_268207_3 Type IV pilus assembly protein PilM; K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 441.0
TLS2_k127_268207_4 AMIN domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 420.0
TLS2_k127_268207_5 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 299.0
TLS2_k127_268207_6 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002819 261.0
TLS2_k127_268207_7 Helix-turn-helix XRE-family like proteins K21498 - - 0.000000000000000000000000000000004547 138.0
TLS2_k127_268207_8 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000000000000007585 124.0
TLS2_k127_268207_9 Fimbrial assembly protein (PilN) - - - 0.000000000000000000000002271 111.0
TLS2_k127_2683636_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 3.427e-219 711.0
TLS2_k127_2683636_1 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 593.0
TLS2_k127_2683636_10 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 359.0
TLS2_k127_2683636_11 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 356.0
TLS2_k127_2683636_12 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 316.0
TLS2_k127_2683636_13 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005786 311.0
TLS2_k127_2683636_14 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003008 265.0
TLS2_k127_2683636_15 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000003306 198.0
TLS2_k127_2683636_16 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000005907 167.0
TLS2_k127_2683636_17 DUF218 domain - - - 0.000000000000000000000000000000000000004679 153.0
TLS2_k127_2683636_18 YoeB-like toxin of bacterial type II toxin-antitoxin system K19158 - - 0.000000000000000000000000000004017 124.0
TLS2_k127_2683636_19 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000005662 119.0
TLS2_k127_2683636_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 555.0
TLS2_k127_2683636_20 Rhomboid family - - - 0.00000000000000000000000000003103 128.0
TLS2_k127_2683636_21 Antitoxin component of a toxin-antitoxin (TA) module K19159 - - 0.00000000000000000000971 95.0
TLS2_k127_2683636_22 - - - - 0.0000000000006314 78.0
TLS2_k127_2683636_23 Ribosomal protein L34 K02914 - - 0.000000000002821 73.0
TLS2_k127_2683636_24 Sporulation related domain - - - 0.000000003682 67.0
TLS2_k127_2683636_25 Iron-binding zinc finger CDGSH type - - - 0.000000006253 60.0
TLS2_k127_2683636_26 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000009166 57.0
TLS2_k127_2683636_27 - - - - 0.0001254 50.0
TLS2_k127_2683636_28 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000182 49.0
TLS2_k127_2683636_29 Domain of unknown function (DUF4440) - - - 0.0004643 49.0
TLS2_k127_2683636_3 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 541.0
TLS2_k127_2683636_4 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007995 503.0
TLS2_k127_2683636_5 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000609 477.0
TLS2_k127_2683636_6 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 454.0
TLS2_k127_2683636_7 Belongs to the D-alanine--D-alanine ligase family K01921 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 376.0
TLS2_k127_2683636_8 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 368.0
TLS2_k127_2683636_9 Zn-dependent protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 353.0
TLS2_k127_2687062_0 Tricorn protease C1 domain K08676 - - 0.0 1294.0
TLS2_k127_2687062_1 TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family K17760 - 1.1.9.1 2.451e-247 783.0
TLS2_k127_2687062_10 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 513.0
TLS2_k127_2687062_11 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 421.0
TLS2_k127_2687062_12 PFAM RES domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 294.0
TLS2_k127_2687062_13 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006083 266.0
TLS2_k127_2687062_14 ribonuclease activity - - - 0.0000000000000000000000000000000000000000000003448 169.0
TLS2_k127_2687062_15 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000000000000000005358 170.0
TLS2_k127_2687062_17 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000002493 141.0
TLS2_k127_2687062_18 Haem-degrading - - - 0.000000000000000000000000001908 118.0
TLS2_k127_2687062_19 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000000000000000000006317 106.0
TLS2_k127_2687062_2 protein kinase activity - - - 2.949e-211 687.0
TLS2_k127_2687062_3 ThiC-associated domain K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 7.769e-201 627.0
TLS2_k127_2687062_4 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 631.0
TLS2_k127_2687062_5 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 612.0
TLS2_k127_2687062_6 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 611.0
TLS2_k127_2687062_7 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 602.0
TLS2_k127_2687062_8 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003704 576.0
TLS2_k127_2687062_9 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 584.0
TLS2_k127_2805093_0 Outer membrane protein beta-barrel domain - - - 0.0000001168 62.0
TLS2_k127_2805093_1 amine dehydrogenase activity - - - 0.000003568 59.0
TLS2_k127_2805093_2 DSBA-like thioredoxin domain - - - 0.00001681 50.0
TLS2_k127_2809055_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 2076.0
TLS2_k127_2809055_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2023.0
TLS2_k127_2809055_10 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000006727 157.0
TLS2_k127_2809055_11 Ribosomal protein L33 K02913 - - 0.000000000000000000000001197 103.0
TLS2_k127_2809055_12 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000003749 86.0
TLS2_k127_2809055_13 SecE/Sec61-gamma subunits of protein translocation complex K03073 - - 0.0000001106 56.0
TLS2_k127_2809055_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.039e-288 905.0
TLS2_k127_2809055_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 315.0
TLS2_k127_2809055_4 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000244 268.0
TLS2_k127_2809055_5 Leishmanolysin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001596 271.0
TLS2_k127_2809055_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000002542 238.0
TLS2_k127_2809055_7 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000004277 225.0
TLS2_k127_2809055_8 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000002391 205.0
TLS2_k127_2809055_9 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000001057 175.0
TLS2_k127_2830350_0 Threonyl alanyl tRNA synthetase SAD K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 374.0
TLS2_k127_2830350_1 Nicotinamide mononucleotide transporter K03811 - - 0.000000000000000000000000000000000000003759 151.0
TLS2_k127_2830350_2 NHL repeat - - - 0.000005576 58.0
TLS2_k127_2858411_0 Zinc carboxypeptidase K14054 - - 3.406e-316 994.0
TLS2_k127_2858411_1 Glutaryl-7-ACA acylase K06978 - - 1.035e-315 978.0
TLS2_k127_2858411_10 Domain of unknown function (DUF4153) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 588.0
TLS2_k127_2858411_100 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.0000000000000000000000005833 113.0
TLS2_k127_2858411_101 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.000000000000000000000004775 111.0
TLS2_k127_2858411_102 Ribosomal protein S21 K02970 - - 0.000000000000000000000005691 102.0
TLS2_k127_2858411_103 PFAM peptidase M55 D-aminopeptidase K16203 - - 0.00000000000000000000003848 114.0
TLS2_k127_2858411_104 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000006552 96.0
TLS2_k127_2858411_105 transport - - - 0.00000000000000000001877 102.0
TLS2_k127_2858411_106 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.0000000000000000004393 93.0
TLS2_k127_2858411_107 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000001962 83.0
TLS2_k127_2858411_108 CarboxypepD_reg-like domain - - - 0.000000000000008611 83.0
TLS2_k127_2858411_109 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000009499 70.0
TLS2_k127_2858411_11 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 587.0
TLS2_k127_2858411_110 Regulatory protein RecX K03565 - - 0.0000000002666 69.0
TLS2_k127_2858411_111 TonB dependent receptor K02014 - - 0.0000000008998 70.0
TLS2_k127_2858411_112 Carboxypeptidase regulatory-like domain - - - 0.00002827 55.0
TLS2_k127_2858411_113 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00007002 48.0
TLS2_k127_2858411_114 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.00009176 48.0
TLS2_k127_2858411_115 Prokaryotic N-terminal methylation motif - - - 0.0001216 51.0
TLS2_k127_2858411_116 Tetratricopeptide repeat - - - 0.0004099 53.0
TLS2_k127_2858411_117 TonB-linked outer membrane protein, SusC RagA family - - - 0.0008517 52.0
TLS2_k127_2858411_12 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000908 580.0
TLS2_k127_2858411_13 B3/4 domain K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 604.0
TLS2_k127_2858411_14 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 569.0
TLS2_k127_2858411_15 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 549.0
TLS2_k127_2858411_16 Oxidoreductase family, C-terminal alpha/beta domain K13020 - 1.1.1.335 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 522.0
TLS2_k127_2858411_17 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 527.0
TLS2_k127_2858411_18 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 502.0
TLS2_k127_2858411_19 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 499.0
TLS2_k127_2858411_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 3.313e-277 863.0
TLS2_k127_2858411_20 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 490.0
TLS2_k127_2858411_21 DHH family K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 479.0
TLS2_k127_2858411_22 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000556 483.0
TLS2_k127_2858411_23 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 447.0
TLS2_k127_2858411_24 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 441.0
TLS2_k127_2858411_25 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 447.0
TLS2_k127_2858411_26 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 483.0
TLS2_k127_2858411_27 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003127 469.0
TLS2_k127_2858411_28 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 452.0
TLS2_k127_2858411_29 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 428.0
TLS2_k127_2858411_3 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 5.138e-268 839.0
TLS2_k127_2858411_30 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 410.0
TLS2_k127_2858411_31 Phosphate-selective porin O and P K07221 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008932 404.0
TLS2_k127_2858411_32 C4-dicarboxylate transmembrane transporter activity K03326 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 386.0
TLS2_k127_2858411_33 3-phosphoshikimate 1-carboxyvinyltransferase activity K00800 GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 382.0
TLS2_k127_2858411_34 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 377.0
TLS2_k127_2858411_35 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009972 366.0
TLS2_k127_2858411_36 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 370.0
TLS2_k127_2858411_37 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 367.0
TLS2_k127_2858411_38 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 365.0
TLS2_k127_2858411_39 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 375.0
TLS2_k127_2858411_4 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 2.818e-255 797.0
TLS2_k127_2858411_40 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 370.0
TLS2_k127_2858411_41 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 349.0
TLS2_k127_2858411_42 SurA N-terminal domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 356.0
TLS2_k127_2858411_43 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007319 335.0
TLS2_k127_2858411_44 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 334.0
TLS2_k127_2858411_45 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 328.0
TLS2_k127_2858411_46 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 325.0
TLS2_k127_2858411_47 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 314.0
TLS2_k127_2858411_48 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 314.0
TLS2_k127_2858411_49 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 308.0
TLS2_k127_2858411_5 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 4.856e-242 766.0
TLS2_k127_2858411_50 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 303.0
TLS2_k127_2858411_51 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002009 297.0
TLS2_k127_2858411_52 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006516 278.0
TLS2_k127_2858411_53 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000001456 266.0
TLS2_k127_2858411_54 asparaginase activity K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002119 258.0
TLS2_k127_2858411_55 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002661 252.0
TLS2_k127_2858411_56 Arginine deiminase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000006812 259.0
TLS2_k127_2858411_57 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000001537 244.0
TLS2_k127_2858411_58 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000004196 247.0
TLS2_k127_2858411_59 triphosphatase activity K01768 GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0050355 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000006176 237.0
TLS2_k127_2858411_6 Zinc carboxypeptidase - - - 5.108e-230 739.0
TLS2_k127_2858411_60 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000002506 238.0
TLS2_k127_2858411_61 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000005278 231.0
TLS2_k127_2858411_62 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000001615 235.0
TLS2_k127_2858411_63 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000004488 224.0
TLS2_k127_2858411_64 DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000000000000001691 224.0
TLS2_k127_2858411_65 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000001107 215.0
TLS2_k127_2858411_66 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000003185 205.0
TLS2_k127_2858411_67 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000004589 222.0
TLS2_k127_2858411_68 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000008725 207.0
TLS2_k127_2858411_69 transporter K07238,K11021,K16267 - - 0.000000000000000000000000000000000000000000000000000001133 203.0
TLS2_k127_2858411_7 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 3.227e-224 724.0
TLS2_k127_2858411_70 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000001706 196.0
TLS2_k127_2858411_71 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000001326 195.0
TLS2_k127_2858411_72 2-phosphosulpholactate phosphatase K05979 - 3.1.3.71 0.000000000000000000000000000000000000000000000000003549 197.0
TLS2_k127_2858411_73 PFAM Exopolysaccharide synthesis, ExoD - - - 0.00000000000000000000000000000000000000000000000002984 188.0
TLS2_k127_2858411_74 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000353 196.0
TLS2_k127_2858411_75 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000009421 184.0
TLS2_k127_2858411_76 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000001841 173.0
TLS2_k127_2858411_77 EXOIII K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000001892 184.0
TLS2_k127_2858411_78 Met-10+ like-protein K02687 - - 0.0000000000000000000000000000000000000000000000262 181.0
TLS2_k127_2858411_79 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000008295 176.0
TLS2_k127_2858411_8 Ftsk_gamma K03466 - - 6.893e-213 686.0
TLS2_k127_2858411_80 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000009466 183.0
TLS2_k127_2858411_81 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000004953 169.0
TLS2_k127_2858411_82 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000000000000002055 171.0
TLS2_k127_2858411_83 ECF sigma factor - - - 0.00000000000000000000000000000000000000000001518 170.0
TLS2_k127_2858411_84 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000004584 166.0
TLS2_k127_2858411_85 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000008837 164.0
TLS2_k127_2858411_86 HIT domain K02503 - - 0.000000000000000000000000000000000000006229 151.0
TLS2_k127_2858411_87 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000001204 153.0
TLS2_k127_2858411_88 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate - - - 0.0000000000000000000000000000000000001847 149.0
TLS2_k127_2858411_89 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000003966 144.0
TLS2_k127_2858411_9 Di- and tricarboxylate transporters K14445 - - 1.643e-209 664.0
TLS2_k127_2858411_90 Yqey-like protein K09117 - - 0.00000000000000000000000000000000006459 147.0
TLS2_k127_2858411_91 - - - - 0.0000000000000000000000000000000009555 133.0
TLS2_k127_2858411_92 STAS domain K04749 - - 0.000000000000000000000000000000002529 142.0
TLS2_k127_2858411_93 CotH kinase protein - - - 0.000000000000000000000000000000002775 140.0
TLS2_k127_2858411_94 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000004251 131.0
TLS2_k127_2858411_95 Biotin-requiring enzyme - - - 0.00000000000000000000000000000006324 132.0
TLS2_k127_2858411_96 CopG antitoxin of type II toxin-antitoxin system - - - 0.00000000000000000000000000004218 120.0
TLS2_k127_2858411_97 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000008821 131.0
TLS2_k127_2858411_98 PFAM plasmid K06218 - - 0.00000000000000000000000004776 109.0
TLS2_k127_2858411_99 Uncharacterised protein family UPF0102 K07460 - - 0.0000000000000000000000003607 112.0
TLS2_k127_2902581_0 filamentation induced by cAMP protein Fic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008911 478.0
TLS2_k127_2902581_1 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 444.0
TLS2_k127_2902581_10 Phosphoribosyl transferase domain K07100 - - 0.000001214 55.0
TLS2_k127_2902581_2 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000811 286.0
TLS2_k127_2902581_3 phosphoribosyltransferase K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000129 251.0
TLS2_k127_2902581_4 Erythromycin esterase K06880 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001899 257.0
TLS2_k127_2902581_5 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001089 235.0
TLS2_k127_2902581_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000002449 132.0
TLS2_k127_2902581_7 Helix-turn-helix domain - - - 0.00000000000000000005069 97.0
TLS2_k127_2902581_9 Domain of unknown function (DUF4377) - - - 0.0000000000000007919 85.0
TLS2_k127_2921085_0 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 385.0
TLS2_k127_2921085_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 387.0
TLS2_k127_2921085_10 transport - - - 0.000000000009046 70.0
TLS2_k127_2921085_2 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000002477 252.0
TLS2_k127_2921085_3 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000001344 228.0
TLS2_k127_2921085_4 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000001972 234.0
TLS2_k127_2921085_5 diacylglycerol kinase, catalytic region - - - 0.0000000000000000000000000000000000000764 155.0
TLS2_k127_2921085_6 NlpC/P60 family - - - 0.00000000000000000000000000000001168 138.0
TLS2_k127_2921085_7 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000001738 141.0
TLS2_k127_2921085_8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000005914 94.0
TLS2_k127_2921085_9 PFAM S23 ribosomal protein - - - 0.000000000000001284 81.0
TLS2_k127_2929629_0 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 5.83e-216 674.0
TLS2_k127_2929629_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 586.0
TLS2_k127_2929629_10 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000004283 234.0
TLS2_k127_2929629_11 Ham1 family K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000002268 188.0
TLS2_k127_2929629_12 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000001548 171.0
TLS2_k127_2929629_13 Acyl-transferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000004353 178.0
TLS2_k127_2929629_14 Calcineurin-like phosphoesterase K03269 - 3.6.1.54 0.00000000000000000000000000000000000000004039 166.0
TLS2_k127_2929629_15 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000000009531 161.0
TLS2_k127_2929629_16 DUF218 domain - - - 0.000000000000000000000000000000007312 138.0
TLS2_k127_2929629_17 Lipopolysaccharide-assembly - - - 0.000000000000000000000000000002971 127.0
TLS2_k127_2929629_18 Thioesterase-like superfamily K07107 - - 0.000000000000000000000045 113.0
TLS2_k127_2929629_19 - - - - 0.000000000000421 78.0
TLS2_k127_2929629_2 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005235 578.0
TLS2_k127_2929629_20 - - - - 0.0000007572 60.0
TLS2_k127_2929629_21 - - - - 0.00008544 47.0
TLS2_k127_2929629_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 562.0
TLS2_k127_2929629_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008032 522.0
TLS2_k127_2929629_5 stress, protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 449.0
TLS2_k127_2929629_6 MatE K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 405.0
TLS2_k127_2929629_7 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 291.0
TLS2_k127_2929629_8 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 293.0
TLS2_k127_2929629_9 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003791 287.0
TLS2_k127_2930386_0 LVIVD repeat - - - 2.061e-224 700.0
TLS2_k127_2930386_1 Sulfate permease family K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 614.0
TLS2_k127_2930386_2 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000000008565 177.0
TLS2_k127_2930386_3 - - - - 0.00000000000000001449 82.0
TLS2_k127_2930386_4 - - - - 0.00000004357 61.0
TLS2_k127_2934866_0 C-5 cytosine-specific DNA methylase K00558 - 2.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 490.0
TLS2_k127_2934866_1 EcoRII C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 373.0
TLS2_k127_2934866_10 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000000000361 95.0
TLS2_k127_2934866_11 Cupin 2, conserved barrel domain protein - - - 0.000000000000000001156 90.0
TLS2_k127_2934866_12 Plasmid stability protein K21495 - - 0.0000000211 61.0
TLS2_k127_2934866_13 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000001059 57.0
TLS2_k127_2934866_2 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 324.0
TLS2_k127_2934866_3 Branched-chain amino acid transport system / permease component K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 297.0
TLS2_k127_2934866_4 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001841 278.0
TLS2_k127_2934866_5 May nick specific sequences that contain T G mispairs resulting from m5C-deamination K07458 - - 0.0000000000000000000000000000000000000000000002853 172.0
TLS2_k127_2934866_6 PIN domain - - - 0.0000000000000000000000000000007363 126.0
TLS2_k127_2934866_7 PIN domain - - - 0.00000000000000000000003937 103.0
TLS2_k127_2934866_8 5-methylcytosine-specific restriction enzyme K07451 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008327,GO:0036094,GO:0043565,GO:0097159,GO:1901265,GO:1901363 - 0.0000000000000000000001353 108.0
TLS2_k127_2934866_9 SPTR Addiction module toxin, RelE StbE family K06218 - - 0.000000000000000000002883 95.0
TLS2_k127_2958607_0 Sortilin, neurotensin receptor 3, - - - 7.99e-321 1016.0
TLS2_k127_2958607_1 Prolyl oligopeptidase family - - - 2.003e-318 1006.0
TLS2_k127_2958607_10 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.00000000000000000000000000003359 126.0
TLS2_k127_2958607_11 domain protein K13735 - - 0.00000000000000000000000001984 119.0
TLS2_k127_2958607_12 pathogenesis - - - 0.00000000000000000002071 104.0
TLS2_k127_2958607_13 Resistance protein K07156 - - 0.0000000002001 66.0
TLS2_k127_2958607_15 MerC mercury resistance protein - - - 0.00003313 52.0
TLS2_k127_2958607_2 Mismatch repair ATPase (MutS family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 473.0
TLS2_k127_2958607_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 436.0
TLS2_k127_2958607_4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 301.0
TLS2_k127_2958607_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001156 263.0
TLS2_k127_2958607_6 cytochrome c oxidase K02351,K02862 - - 0.000000000000000000000000000000000000000000000006699 185.0
TLS2_k127_2958607_7 Copper chaperone PCu(A)C K03619,K07152,K09796 GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277 - 0.000000000000000000000000000000000000000000002511 171.0
TLS2_k127_2958607_8 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000009528 160.0
TLS2_k127_2958607_9 copper resistance K07245,K14166 - - 0.000000000000000000000000000000003673 141.0
TLS2_k127_2978915_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000001879 126.0
TLS2_k127_3022125_0 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000001038 158.0
TLS2_k127_3022125_1 Carboxypeptidase regulatory-like domain K02014 - - 0.000000001363 69.0
TLS2_k127_3051602_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 3431.0
TLS2_k127_3051602_1 aminopeptidase n - - - 1.901e-195 626.0
TLS2_k127_3051602_10 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000001154 181.0
TLS2_k127_3051602_11 PFAM DGPFAETKE family protein - - - 0.0000000000000000000000000000000000000000000002245 172.0
TLS2_k127_3051602_12 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000004288 156.0
TLS2_k127_3051602_13 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000006129 148.0
TLS2_k127_3051602_14 PFAM helix-turn-helix- domain containing protein, AraC type - - - 0.0000000000000000000000000000000006036 145.0
TLS2_k127_3051602_15 YCII-related domain - - - 0.0000000000000000000000000000002556 126.0
TLS2_k127_3051602_16 - - - - 0.0000000000000000000000000000005247 128.0
TLS2_k127_3051602_17 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000002892 134.0
TLS2_k127_3051602_18 - - - - 0.00000000000000000000000000001092 130.0
TLS2_k127_3051602_19 Transglycosylase associated protein - - - 0.000000000000000000000009157 104.0
TLS2_k127_3051602_2 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 574.0
TLS2_k127_3051602_20 - - - - 0.000000000000003501 87.0
TLS2_k127_3051602_22 Peptidase_C39 like family - - - 0.0000002185 64.0
TLS2_k127_3051602_24 - - - - 0.0000289 56.0
TLS2_k127_3051602_25 - - - - 0.0000684 53.0
TLS2_k127_3051602_3 imidazolonepropionase activity K15358 - 3.5.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009333 466.0
TLS2_k127_3051602_4 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 442.0
TLS2_k127_3051602_5 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 347.0
TLS2_k127_3051602_6 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 347.0
TLS2_k127_3051602_7 Diguanylate cyclase (GGDEF domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005622 264.0
TLS2_k127_3051602_8 Protein of unknown function (DUF3179) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003529 257.0
TLS2_k127_3051602_9 Glycine zipper - - - 0.00000000000000000000000000000000000000000000000000000000000000000003636 237.0
TLS2_k127_3059226_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 6.861e-271 845.0
TLS2_k127_3059226_1 TonB dependent receptor - - - 1.209e-214 698.0
TLS2_k127_3059226_10 O-acyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 364.0
TLS2_k127_3059226_11 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 372.0
TLS2_k127_3059226_12 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009655 331.0
TLS2_k127_3059226_13 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 333.0
TLS2_k127_3059226_14 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 327.0
TLS2_k127_3059226_15 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 325.0
TLS2_k127_3059226_16 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 301.0
TLS2_k127_3059226_17 GIY-YIG type nucleases (URI domain) K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 295.0
TLS2_k127_3059226_18 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 290.0
TLS2_k127_3059226_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008862 303.0
TLS2_k127_3059226_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 2.21e-207 651.0
TLS2_k127_3059226_20 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001478 290.0
TLS2_k127_3059226_21 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000001532 267.0
TLS2_k127_3059226_22 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000008924 272.0
TLS2_k127_3059226_23 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001572 266.0
TLS2_k127_3059226_24 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000002627 226.0
TLS2_k127_3059226_25 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000003274 196.0
TLS2_k127_3059226_26 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000000001282 185.0
TLS2_k127_3059226_27 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000003369 163.0
TLS2_k127_3059226_28 NUDIX domain K08310 - 3.6.1.67 0.00000000000000000000000000000000000000003131 158.0
TLS2_k127_3059226_29 - - - - 0.0000000000000000000000000000000000002973 148.0
TLS2_k127_3059226_3 alanine symporter K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 567.0
TLS2_k127_3059226_30 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000001104 147.0
TLS2_k127_3059226_31 Polymer-forming cytoskeletal - - - 0.0000000000000000000006852 109.0
TLS2_k127_3059226_32 NifU-like domain - - - 0.00000000000005211 74.0
TLS2_k127_3059226_34 - - - - 0.0000002343 60.0
TLS2_k127_3059226_35 NHL repeat - - - 0.0000008127 61.0
TLS2_k127_3059226_36 PIN domain - - - 0.00000737 56.0
TLS2_k127_3059226_37 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.00006526 55.0
TLS2_k127_3059226_38 - - - - 0.0001227 51.0
TLS2_k127_3059226_4 Transporter K12942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 565.0
TLS2_k127_3059226_5 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 516.0
TLS2_k127_3059226_6 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 505.0
TLS2_k127_3059226_7 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007148 475.0
TLS2_k127_3059226_8 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 453.0
TLS2_k127_3059226_9 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 399.0
TLS2_k127_3073982_0 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008298 508.0
TLS2_k127_3073982_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 499.0
TLS2_k127_3073982_2 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000001015 265.0
TLS2_k127_313222_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007813 293.0
TLS2_k127_313222_1 - - - - 0.00000000000000000000000000002623 135.0
TLS2_k127_3154053_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 7.437e-243 759.0
TLS2_k127_3154053_1 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 5.439e-210 666.0
TLS2_k127_3154053_10 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 352.0
TLS2_k127_3154053_11 PFAM Integral membrane protein TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 334.0
TLS2_k127_3154053_12 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007368 314.0
TLS2_k127_3154053_13 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 293.0
TLS2_k127_3154053_14 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003188 282.0
TLS2_k127_3154053_15 peptidase dimerisation domain K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003896 286.0
TLS2_k127_3154053_16 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003242 280.0
TLS2_k127_3154053_17 Belongs to the serpin family K13963 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000345 280.0
TLS2_k127_3154053_18 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000003937 202.0
TLS2_k127_3154053_19 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000001959 192.0
TLS2_k127_3154053_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 8.856e-197 625.0
TLS2_k127_3154053_20 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000001928 162.0
TLS2_k127_3154053_21 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000006999 162.0
TLS2_k127_3154053_22 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000006395 158.0
TLS2_k127_3154053_23 4 iron, 4 sulfur cluster binding K02573 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000001493 141.0
TLS2_k127_3154053_24 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000000000002079 144.0
TLS2_k127_3154053_25 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000001289 136.0
TLS2_k127_3154053_26 FdhD/NarQ family K02379 - - 0.000000000000000000000000000001597 132.0
TLS2_k127_3154053_27 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000005213 107.0
TLS2_k127_3154053_28 - - - - 0.00000000000000001977 87.0
TLS2_k127_3154053_29 molybdopterin-guanine dinucleotide biosynthesis protein K03753 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000004172 88.0
TLS2_k127_3154053_3 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 1.226e-195 620.0
TLS2_k127_3154053_30 - - - - 0.0000000000008573 77.0
TLS2_k127_3154053_31 response to abiotic stimulus - - - 0.0000000003479 67.0
TLS2_k127_3154053_4 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 443.0
TLS2_k127_3154053_5 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 409.0
TLS2_k127_3154053_6 Electron transfer flavoprotein domain K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 377.0
TLS2_k127_3154053_7 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 379.0
TLS2_k127_3154053_8 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 373.0
TLS2_k127_3154053_9 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005264 369.0
TLS2_k127_3159399_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 536.0
TLS2_k127_3159399_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000002815 55.0
TLS2_k127_3159697_0 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.0 1019.0
TLS2_k127_3159697_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 2.123e-244 777.0
TLS2_k127_3159697_10 SMART von Willebrand factor, type A K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001364 275.0
TLS2_k127_3159697_11 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002819 258.0
TLS2_k127_3159697_12 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000179 248.0
TLS2_k127_3159697_13 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000001839 239.0
TLS2_k127_3159697_14 Methyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000005273 241.0
TLS2_k127_3159697_15 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000002434 237.0
TLS2_k127_3159697_16 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002822 224.0
TLS2_k127_3159697_17 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.0000000000000000000000000000000000000000000000000000000000007498 214.0
TLS2_k127_3159697_18 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000006551 212.0
TLS2_k127_3159697_19 - - - - 0.0000000000000000000000000000000000000000000000000000003498 198.0
TLS2_k127_3159697_2 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006889 472.0
TLS2_k127_3159697_20 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000003293 211.0
TLS2_k127_3159697_21 - - - - 0.000000000000000000000000000000000000000000000009077 176.0
TLS2_k127_3159697_22 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000001032 176.0
TLS2_k127_3159697_23 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000002349 177.0
TLS2_k127_3159697_24 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000002417 168.0
TLS2_k127_3159697_25 - - - - 0.000000000000000000000000000000000000000004502 164.0
TLS2_k127_3159697_26 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000000000000001447 154.0
TLS2_k127_3159697_27 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000006916 143.0
TLS2_k127_3159697_28 Plasmid maintenance system killer K07334 - - 0.000000000000000000000000000000000002772 139.0
TLS2_k127_3159697_29 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000000000001938 131.0
TLS2_k127_3159697_3 response to abiotic stimulus K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 456.0
TLS2_k127_3159697_30 - - - - 0.000000000000000000000000000000005176 132.0
TLS2_k127_3159697_31 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.00000000000000000000000001428 114.0
TLS2_k127_3159697_32 - - - - 0.000000000000000000000002662 111.0
TLS2_k127_3159697_33 BrnA antitoxin of type II toxin-antitoxin system - - - 0.00000000000000000000001114 104.0
TLS2_k127_3159697_34 - - - - 0.000000000000000001416 94.0
TLS2_k127_3159697_35 Phage integrase, N-terminal SAM-like domain - - - 0.0000000000000003341 87.0
TLS2_k127_3159697_36 Antibiotic biosynthesis monooxygenase K06996 - - 0.00000000002788 70.0
TLS2_k127_3159697_37 - - - - 0.00000001134 66.0
TLS2_k127_3159697_38 - - - - 0.00008313 52.0
TLS2_k127_3159697_4 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 408.0
TLS2_k127_3159697_5 ErfK YbiS YcfS YnhG family protein K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 406.0
TLS2_k127_3159697_6 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 377.0
TLS2_k127_3159697_7 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 351.0
TLS2_k127_3159697_8 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008065 308.0
TLS2_k127_3159697_9 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002258 275.0
TLS2_k127_3180189_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 509.0
TLS2_k127_3180189_1 Histidine Phosphotransfer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 364.0
TLS2_k127_3180189_10 - - - - 0.00000000008365 74.0
TLS2_k127_3180189_11 Thioredoxin-like K06196 - - 0.00001258 59.0
TLS2_k127_3180189_2 type II secretion system protein E K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003383 277.0
TLS2_k127_3180189_3 2Fe-2S -binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000005165 207.0
TLS2_k127_3180189_4 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000001181 173.0
TLS2_k127_3180189_5 Belongs to the UPF0312 family - - - 0.000000000000000000000000000001077 131.0
TLS2_k127_3180189_6 - - - - 0.00000000000000000000000000108 119.0
TLS2_k127_3180189_7 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K07303 - 1.3.99.16 0.00000000000000000000000002217 115.0
TLS2_k127_3180189_8 Sigma-70 region 2 K03088 - - 0.000000000000781 77.0
TLS2_k127_3180189_9 - - - - 0.00000000000324 71.0
TLS2_k127_3252571_0 Amidohydrolase family - - - 0.0 1152.0
TLS2_k127_3252571_1 DNA ligase K01971 - 6.5.1.1 3.913e-296 931.0
TLS2_k127_3252571_10 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 291.0
TLS2_k127_3252571_11 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007034 298.0
TLS2_k127_3252571_12 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005653 288.0
TLS2_k127_3252571_13 response regulator K07782 - - 0.0000000000000000000000000000000000000000000000000000000000000000000543 242.0
TLS2_k127_3252571_14 Uncharacterized BCR, YaiI/YqxD family COG1671 K09768 - - 0.000000000000000000000000000000000000000000000008329 176.0
TLS2_k127_3252571_15 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000006344 175.0
TLS2_k127_3252571_16 response regulator K07782 - - 0.0000000000000000000000000000000000000000002747 166.0
TLS2_k127_3252571_17 - - - - 0.000000000000000000000000000000000000000003714 162.0
TLS2_k127_3252571_18 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000003452 161.0
TLS2_k127_3252571_19 Belongs to the peptidase S51 family K13282 - 3.4.15.6 0.00000000000000000000000000000003703 128.0
TLS2_k127_3252571_2 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 628.0
TLS2_k127_3252571_20 - - - - 0.000000000000000000166 98.0
TLS2_k127_3252571_21 nucleoside-diphosphate sugar epimerase K07071 - - 0.0000000000000000002049 92.0
TLS2_k127_3252571_23 - - - - 0.00003934 52.0
TLS2_k127_3252571_24 Cro/C1-type HTH DNA-binding domain K07727 - - 0.0003982 46.0
TLS2_k127_3252571_3 argininosuccinate synthase activity K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 574.0
TLS2_k127_3252571_4 radical SAM domain protein K03639,K15045 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 496.0
TLS2_k127_3252571_5 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 515.0
TLS2_k127_3252571_6 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 424.0
TLS2_k127_3252571_7 Domain of unknown function (DUF4159) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004054 341.0
TLS2_k127_3252571_8 Glutamine amidotransferase class-I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 319.0
TLS2_k127_3252571_9 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 300.0
TLS2_k127_3269899_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 450.0
TLS2_k127_3269899_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 409.0
TLS2_k127_3269899_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 353.0
TLS2_k127_3269899_3 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000005139 202.0
TLS2_k127_3269899_4 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000001056 130.0
TLS2_k127_342008_0 Amidohydrolase family - - - 0.0 1348.0
TLS2_k127_342008_1 Amidohydrolase family - - - 0.0 1173.0
TLS2_k127_342008_10 Cytochrome c K19713 - 1.8.2.2 0.00000016 61.0
TLS2_k127_342008_11 amine dehydrogenase activity - - - 0.000001197 60.0
TLS2_k127_342008_13 6-bladed beta-propeller - - - 0.00005142 55.0
TLS2_k127_342008_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 304.0
TLS2_k127_342008_3 peptide catabolic process K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000003105 192.0
TLS2_k127_342008_4 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000001398 176.0
TLS2_k127_342008_5 Penicillinase repressor - - - 0.0000000000000000000000000000000002732 137.0
TLS2_k127_342008_6 DinB family - - - 0.0000000000000000000000000000004819 130.0
TLS2_k127_342008_7 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000000000000005679 108.0
TLS2_k127_342008_8 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000000002196 99.0
TLS2_k127_3474538_0 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 473.0
TLS2_k127_3474538_1 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001004 269.0
TLS2_k127_3474538_10 - - - - 0.0000002473 61.0
TLS2_k127_3474538_2 - - - - 0.0000000000000000000000000000000000000000000000258 190.0
TLS2_k127_3474538_3 PFAM WD40 repeat, subgroup - - - 0.00000000000000000000000000000000000002632 154.0
TLS2_k127_3474538_4 Putative inner membrane exporter, YdcZ K09936 - - 0.00000000000000000000000000000003136 138.0
TLS2_k127_3474538_5 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000008209 124.0
TLS2_k127_3474538_6 - - - - 0.0000000000000000000000000004053 118.0
TLS2_k127_3474538_7 PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain K07443 - - 0.00000000000000000000001043 105.0
TLS2_k127_3474538_8 Dodecin K09165 - - 0.000000000000000000001492 98.0
TLS2_k127_3474538_9 - - - - 0.00000000006263 72.0
TLS2_k127_3501607_0 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 377.0
TLS2_k127_3501607_1 Dienelactone hydrolase family K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002099 259.0
TLS2_k127_3501607_2 helix_turn_helix multiple antibiotic resistance protein K15973 - - 0.0000000000000000000000000000000000000009486 152.0
TLS2_k127_3501607_3 IMP dehydrogenase activity K06041,K11527 - 2.7.13.3,5.3.1.13 0.00000000000003556 78.0
TLS2_k127_359782_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 4.849e-220 695.0
TLS2_k127_359782_1 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000047 197.0
TLS2_k127_3630641_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0 1112.0
TLS2_k127_3630641_1 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 8.057e-207 683.0
TLS2_k127_3630641_10 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 323.0
TLS2_k127_3630641_11 Transcriptional regulatory protein, C terminal K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 305.0
TLS2_k127_3630641_12 Phosphate transport system permease protein PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002844 291.0
TLS2_k127_3630641_13 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005795 275.0
TLS2_k127_3630641_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002534 269.0
TLS2_k127_3630641_15 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001359 262.0
TLS2_k127_3630641_16 negative regulation of phosphate transmembrane transport K02039 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000000000000001315 240.0
TLS2_k127_3630641_17 - - - - 0.00000000000000000000000003912 122.0
TLS2_k127_3630641_18 DNA-binding transcription factor activity K03892 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000001808 66.0
TLS2_k127_3630641_19 - - - - 0.0007869 50.0
TLS2_k127_3630641_2 deoxyribose-phosphate aldolase activity K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 474.0
TLS2_k127_3630641_3 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 432.0
TLS2_k127_3630641_4 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 427.0
TLS2_k127_3630641_5 TIGRFAM phosphate ABC transporter, phosphate-binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 369.0
TLS2_k127_3630641_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 328.0
TLS2_k127_3630641_7 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 323.0
TLS2_k127_3630641_8 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 320.0
TLS2_k127_3630641_9 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 329.0
TLS2_k127_363625_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1154.0
TLS2_k127_363625_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 6.859e-233 745.0
TLS2_k127_363625_10 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 362.0
TLS2_k127_363625_11 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 338.0
TLS2_k127_363625_12 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009937 319.0
TLS2_k127_363625_13 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006057 317.0
TLS2_k127_363625_14 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 299.0
TLS2_k127_363625_15 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000193 289.0
TLS2_k127_363625_16 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001216 269.0
TLS2_k127_363625_17 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001867 262.0
TLS2_k127_363625_18 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001026 257.0
TLS2_k127_363625_19 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000008164 260.0
TLS2_k127_363625_2 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 6.238e-214 677.0
TLS2_k127_363625_20 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001353 255.0
TLS2_k127_363625_21 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002231 244.0
TLS2_k127_363625_22 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000009766 237.0
TLS2_k127_363625_23 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000007198 246.0
TLS2_k127_363625_24 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000006416 231.0
TLS2_k127_363625_25 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000008375 214.0
TLS2_k127_363625_26 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000216 213.0
TLS2_k127_363625_27 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000003772 173.0
TLS2_k127_363625_28 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000005019 174.0
TLS2_k127_363625_29 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000008289 154.0
TLS2_k127_363625_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 563.0
TLS2_k127_363625_30 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000003565 152.0
TLS2_k127_363625_31 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000004237 154.0
TLS2_k127_363625_32 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000000005403 136.0
TLS2_k127_363625_33 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000113 128.0
TLS2_k127_363625_34 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000118 128.0
TLS2_k127_363625_35 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000002541 133.0
TLS2_k127_363625_36 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000000002139 113.0
TLS2_k127_363625_37 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000002606 96.0
TLS2_k127_363625_38 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000537 98.0
TLS2_k127_363625_39 - - - - 0.00000000000000001251 85.0
TLS2_k127_363625_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 491.0
TLS2_k127_363625_40 Ribosomal protein L30p/L7e K02907 - - 0.00000000000000001425 86.0
TLS2_k127_363625_41 Zincin-like metallopeptidase - - - 0.0000000000000001725 90.0
TLS2_k127_363625_42 Ribosomal L29 protein K02904 - - 0.0000000005847 61.0
TLS2_k127_363625_43 - - - - 0.000002022 59.0
TLS2_k127_363625_44 PFAM FHA domain - - - 0.000005081 59.0
TLS2_k127_363625_45 - - - - 0.00002978 52.0
TLS2_k127_363625_46 serine-type endopeptidase activity - GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006091,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009719,GO:0009725,GO:0009735,GO:0009765,GO:0009987,GO:0010033,GO:0010206,GO:0015979,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019684,GO:0030091,GO:0030163,GO:0031976,GO:0031977,GO:0031984,GO:0034357,GO:0042221,GO:0042651,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0055035,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0007621 52.0
TLS2_k127_363625_5 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 444.0
TLS2_k127_363625_6 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 434.0
TLS2_k127_363625_7 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 427.0
TLS2_k127_363625_8 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 362.0
TLS2_k127_363625_9 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 363.0
TLS2_k127_3641641_0 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000522 78.0
TLS2_k127_3641641_1 Nodulation protein S (NodS) - - - 0.000007146 49.0
TLS2_k127_3641641_2 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0002365 53.0
TLS2_k127_3854107_0 lysine biosynthetic process via aminoadipic acid - - - 1.185e-261 835.0
TLS2_k127_3854107_1 Flavin-binding monooxygenase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 481.0
TLS2_k127_3854107_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000007679 205.0
TLS2_k127_3854107_11 Cytidylate kinase K00876 - 2.7.1.48 0.000000000000000000000000000000000000000000000000000000207 197.0
TLS2_k127_3854107_12 Conserved TM helix - - - 0.00000000000000000000000000000000000000000000000000005663 195.0
TLS2_k127_3854107_13 Tetratricopeptide repeat K08309 - - 0.0000000000000000000000000000000000000000000000000113 203.0
TLS2_k127_3854107_14 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.0000000000000000000000000000001735 134.0
TLS2_k127_3854107_15 - - - - 0.000000000000000000000000001165 124.0
TLS2_k127_3854107_16 - - - - 0.0000000000001604 82.0
TLS2_k127_3854107_17 amine dehydrogenase activity - - - 0.00000008304 64.0
TLS2_k127_3854107_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000001456 57.0
TLS2_k127_3854107_19 - - - - 0.000002293 52.0
TLS2_k127_3854107_2 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 427.0
TLS2_k127_3854107_3 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 398.0
TLS2_k127_3854107_4 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 330.0
TLS2_k127_3854107_5 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 322.0
TLS2_k127_3854107_6 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007304 316.0
TLS2_k127_3854107_7 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000396 271.0
TLS2_k127_3854107_8 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006593 269.0
TLS2_k127_3854107_9 serine threonine protein kinase K00870 - 2.7.1.37 0.00000000000000000000000000000000000000000000000000000000001406 224.0
TLS2_k127_3890187_0 Type II secretion system (T2SS), protein F K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 542.0
TLS2_k127_3890187_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 492.0
TLS2_k127_3890187_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000001725 98.0
TLS2_k127_3900241_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 1.498e-209 672.0
TLS2_k127_3900241_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 556.0
TLS2_k127_3900241_10 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000005016 196.0
TLS2_k127_3900241_11 Glycosyl transferase, family 9 K02843 - - 0.0000000000000000000000000000000000000000000000000004453 198.0
TLS2_k127_3900241_12 transferase activity, transferring glycosyl groups K00713,K06338 - - 0.00000000000000000000000000000000000000000000000001047 192.0
TLS2_k127_3900241_13 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000004961 184.0
TLS2_k127_3900241_14 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.0000000000000001616 93.0
TLS2_k127_3900241_15 - - - - 0.00000006166 63.0
TLS2_k127_3900241_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 490.0
TLS2_k127_3900241_3 ABC transporter transmembrane region K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 464.0
TLS2_k127_3900241_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 325.0
TLS2_k127_3900241_5 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009649 314.0
TLS2_k127_3900241_6 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000052 286.0
TLS2_k127_3900241_7 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000443 285.0
TLS2_k127_3900241_8 4Fe-4S single cluster domain K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003631 275.0
TLS2_k127_3900241_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002576 260.0
TLS2_k127_3907879_0 PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - 1.985e-239 745.0
TLS2_k127_3907879_1 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000006058 51.0
TLS2_k127_3926788_0 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004906 305.0
TLS2_k127_3926788_1 Thioredoxin - - - 0.0000000004143 67.0
TLS2_k127_3926788_2 LuxR family transcriptional regulator - - - 0.000001078 59.0
TLS2_k127_3926788_3 PFAM NHL repeat containing protein - - - 0.00000511 58.0
TLS2_k127_394379_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000271 264.0
TLS2_k127_394379_1 CarboxypepD_reg-like domain - - - 0.00000000009454 68.0
TLS2_k127_4075503_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 584.0
TLS2_k127_4075503_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 359.0
TLS2_k127_4075503_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000005878 263.0
TLS2_k127_4075503_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000001195 235.0
TLS2_k127_4075503_4 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000004642 166.0
TLS2_k127_4075503_5 - - - - 0.000000000000000000000000000000000514 135.0
TLS2_k127_4075503_6 - - - - 0.00000000000000000000000000575 111.0
TLS2_k127_4075503_7 Septum formation initiator K05589 - - 0.00002059 54.0
TLS2_k127_4095_0 UDP binding domain K00066 - 1.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 509.0
TLS2_k127_4095_1 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 356.0
TLS2_k127_4095_2 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 312.0
TLS2_k127_4109457_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 8.386e-292 908.0
TLS2_k127_4109457_1 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 1.458e-214 682.0
TLS2_k127_4109457_10 CarboxypepD_reg-like domain K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 590.0
TLS2_k127_4109457_11 C4-dicarboxylate anaerobic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 531.0
TLS2_k127_4109457_12 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 496.0
TLS2_k127_4109457_13 fatty acid desaturase K00508 - 1.14.19.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 460.0
TLS2_k127_4109457_14 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 483.0
TLS2_k127_4109457_15 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 454.0
TLS2_k127_4109457_16 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008033 446.0
TLS2_k127_4109457_17 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 408.0
TLS2_k127_4109457_18 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 407.0
TLS2_k127_4109457_19 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 384.0
TLS2_k127_4109457_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 4.69e-211 672.0
TLS2_k127_4109457_20 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 364.0
TLS2_k127_4109457_21 Threonine/Serine exporter, ThrE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008908 347.0
TLS2_k127_4109457_22 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 334.0
TLS2_k127_4109457_23 PFAM Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004661 329.0
TLS2_k127_4109457_24 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 313.0
TLS2_k127_4109457_25 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009034 277.0
TLS2_k127_4109457_26 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001704 273.0
TLS2_k127_4109457_27 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003182 278.0
TLS2_k127_4109457_28 FES K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001657 270.0
TLS2_k127_4109457_29 Domain of unknown function (DUF4956) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002519 257.0
TLS2_k127_4109457_3 Domain of unknown function (DUF5118) - - - 8.706e-209 676.0
TLS2_k127_4109457_30 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002666 245.0
TLS2_k127_4109457_31 PFAM Sodium calcium exchanger membrane region K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000001376 248.0
TLS2_k127_4109457_32 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000006222 238.0
TLS2_k127_4109457_33 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000006501 239.0
TLS2_k127_4109457_34 - - - - 0.00000000000000000000000000000000000000000000000000000000003543 226.0
TLS2_k127_4109457_35 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000001866 212.0
TLS2_k127_4109457_36 - - - - 0.000000000000000000000000000000000000000000000000000000001534 210.0
TLS2_k127_4109457_37 Protein of unknown function (DUF3592) - - - 0.0000000000000000000000000000000000000000000000000000001482 212.0
TLS2_k127_4109457_38 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11473 - - 0.00000000000000000000000000000000000000000000000000003071 198.0
TLS2_k127_4109457_39 - - - - 0.0000000000000000000000000000000000000000000004104 179.0
TLS2_k127_4109457_4 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 1.113e-207 664.0
TLS2_k127_4109457_40 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000006731 175.0
TLS2_k127_4109457_41 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000006934 173.0
TLS2_k127_4109457_42 Paraquat-inducible protein A - - - 0.0000000000000000000000000000000000000000001185 169.0
TLS2_k127_4109457_43 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000001736 156.0
TLS2_k127_4109457_44 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000166 150.0
TLS2_k127_4109457_45 Thioesterase superfamily - - - 0.0000000000000000000000000000000000246 143.0
TLS2_k127_4109457_46 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.0000000000000000000000000000000001999 148.0
TLS2_k127_4109457_47 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000001592 132.0
TLS2_k127_4109457_48 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.0000000000000000000000000000001333 137.0
TLS2_k127_4109457_49 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000000000000000001748 129.0
TLS2_k127_4109457_5 Aminotransferase class-V - - - 4.364e-201 642.0
TLS2_k127_4109457_50 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000002752 133.0
TLS2_k127_4109457_51 Psort location Cytoplasmic, score K00945 - 2.7.4.25 0.00000000000000000000000000001127 126.0
TLS2_k127_4109457_52 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000001618 98.0
TLS2_k127_4109457_53 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.00000000000000000008535 100.0
TLS2_k127_4109457_54 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000058 96.0
TLS2_k127_4109457_55 Phosphoglycerate mutase family - - - 0.000000000000005166 83.0
TLS2_k127_4109457_56 SpoVT / AbrB like domain K18829 - - 0.0000000000003125 73.0
TLS2_k127_4109457_57 DinB family - - - 0.000000000002032 75.0
TLS2_k127_4109457_58 amine dehydrogenase activity - - - 0.000000000003665 78.0
TLS2_k127_4109457_59 Domain of unknown function (DUF1707) - - - 0.00000000002616 74.0
TLS2_k127_4109457_6 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 3.061e-196 622.0
TLS2_k127_4109457_60 COG3794 Plastocyanin - - - 0.00000000008293 72.0
TLS2_k127_4109457_61 Copper binding proteins, plastocyanin/azurin family - - - 0.000000002 64.0
TLS2_k127_4109457_62 deoxyhypusine monooxygenase activity K01387 - 3.4.24.3 0.000002724 61.0
TLS2_k127_4109457_7 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 3.231e-194 631.0
TLS2_k127_4109457_8 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 599.0
TLS2_k127_4109457_9 proline dipeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 599.0
TLS2_k127_415735_0 AcrB/AcrD/AcrF family K07787,K15726 - - 0.0 1219.0
TLS2_k127_415735_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1171.0
TLS2_k127_415735_10 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 533.0
TLS2_k127_415735_100 DivIVA domain protein K04074 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000001546 59.0
TLS2_k127_415735_101 Domain of unknown function (DUF1844) - - - 0.00000293 54.0
TLS2_k127_415735_102 Glycosyl transferase family 41 - - - 0.00001468 55.0
TLS2_k127_415735_103 PFAM sodium calcium exchanger membrane region K07301 - - 0.00003034 49.0
TLS2_k127_415735_104 FR47-like protein - - - 0.00003125 52.0
TLS2_k127_415735_105 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.00008955 49.0
TLS2_k127_415735_11 TIGRFAM Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 514.0
TLS2_k127_415735_12 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 488.0
TLS2_k127_415735_13 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 451.0
TLS2_k127_415735_14 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 442.0
TLS2_k127_415735_15 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 424.0
TLS2_k127_415735_16 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 448.0
TLS2_k127_415735_17 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 427.0
TLS2_k127_415735_18 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 402.0
TLS2_k127_415735_19 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 415.0
TLS2_k127_415735_2 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1094.0
TLS2_k127_415735_20 fructose 1,6-bisphosphate 1-phosphatase activity K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 398.0
TLS2_k127_415735_21 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 419.0
TLS2_k127_415735_22 Elongation factor SelB winged helix 3 K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 409.0
TLS2_k127_415735_23 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 391.0
TLS2_k127_415735_24 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 400.0
TLS2_k127_415735_25 PEP-utilising enzyme, N-terminal K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 391.0
TLS2_k127_415735_26 cobalamin-transporting ATPase activity K02014,K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 376.0
TLS2_k127_415735_27 P2 response regulator binding domain K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 372.0
TLS2_k127_415735_28 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 355.0
TLS2_k127_415735_29 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 353.0
TLS2_k127_415735_3 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.083e-260 818.0
TLS2_k127_415735_30 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 349.0
TLS2_k127_415735_31 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 346.0
TLS2_k127_415735_32 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007389 347.0
TLS2_k127_415735_33 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 329.0
TLS2_k127_415735_34 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 320.0
TLS2_k127_415735_35 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 321.0
TLS2_k127_415735_36 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 317.0
TLS2_k127_415735_37 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 312.0
TLS2_k127_415735_38 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 310.0
TLS2_k127_415735_39 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 314.0
TLS2_k127_415735_4 YHS domain K01533 - 3.6.3.4 5.892e-208 655.0
TLS2_k127_415735_40 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000257 293.0
TLS2_k127_415735_41 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 295.0
TLS2_k127_415735_42 Competence protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000167 302.0
TLS2_k127_415735_43 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004262 292.0
TLS2_k127_415735_44 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001355 294.0
TLS2_k127_415735_45 Cell cycle protein K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003062 281.0
TLS2_k127_415735_46 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003222 280.0
TLS2_k127_415735_47 Small GTP-binding protein K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005727 268.0
TLS2_k127_415735_48 Bacterial dnaA protein K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001972 287.0
TLS2_k127_415735_49 Protein of unknown function (DUF4256) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002643 265.0
TLS2_k127_415735_5 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 5.176e-196 624.0
TLS2_k127_415735_50 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000002928 252.0
TLS2_k127_415735_51 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001091 245.0
TLS2_k127_415735_52 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005294 249.0
TLS2_k127_415735_53 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006808 250.0
TLS2_k127_415735_54 PFAM Nickel transport complex, NikM subunit, transmembrane - - - 0.00000000000000000000000000000000000000000000000000000000000000008656 244.0
TLS2_k127_415735_55 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000002283 232.0
TLS2_k127_415735_56 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000008089 228.0
TLS2_k127_415735_57 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000000000000000000003742 213.0
TLS2_k127_415735_58 CheC-like family K03410 - - 0.0000000000000000000000000000000000000000000000000000000000004105 217.0
TLS2_k127_415735_59 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000004616 212.0
TLS2_k127_415735_6 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004892 576.0
TLS2_k127_415735_60 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000005407 218.0
TLS2_k127_415735_61 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000001898 210.0
TLS2_k127_415735_62 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000001908 187.0
TLS2_k127_415735_63 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000000003882 188.0
TLS2_k127_415735_64 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000007591 186.0
TLS2_k127_415735_65 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000008397 189.0
TLS2_k127_415735_66 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000001035 179.0
TLS2_k127_415735_67 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000001494 184.0
TLS2_k127_415735_68 - - - - 0.000000000000000000000000000000000000000000001672 168.0
TLS2_k127_415735_69 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.00000000000000000000000000000000000000000003952 166.0
TLS2_k127_415735_7 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 564.0
TLS2_k127_415735_70 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000001281 176.0
TLS2_k127_415735_71 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000002532 168.0
TLS2_k127_415735_72 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000001827 154.0
TLS2_k127_415735_73 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000105 154.0
TLS2_k127_415735_74 PTS system sorbose subfamily IIB component K19507 - - 0.000000000000000000000000000000000000004527 156.0
TLS2_k127_415735_75 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000000000000000000000000005793 162.0
TLS2_k127_415735_76 PTS system mannose/fructose/sorbose family IID component K02796 - - 0.0000000000000000000000000000000002079 144.0
TLS2_k127_415735_77 - - - - 0.000000000000000000000000000000002634 142.0
TLS2_k127_415735_78 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000000000002714 134.0
TLS2_k127_415735_79 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000005627 142.0
TLS2_k127_415735_8 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 550.0
TLS2_k127_415735_80 - - - - 0.0000000000000000000000000000001153 136.0
TLS2_k127_415735_81 SnoaL-like domain - - - 0.000000000000000000000000000002907 138.0
TLS2_k127_415735_82 Cytochrome c - - - 0.000000000000000000000000000004502 135.0
TLS2_k127_415735_83 - - - - 0.000000000000000000000000001284 117.0
TLS2_k127_415735_84 - - - - 0.0000000000000000000000002927 122.0
TLS2_k127_415735_85 lactoylglutathione lyase activity - - - 0.000000000000000000000005395 114.0
TLS2_k127_415735_86 DinB family - - - 0.000000000000000000000006605 106.0
TLS2_k127_415735_87 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.00000000000000000000001752 113.0
TLS2_k127_415735_88 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000002633 106.0
TLS2_k127_415735_89 Regulatory protein, FmdB family - - - 0.00000000000000000001059 95.0
TLS2_k127_415735_9 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 551.0
TLS2_k127_415735_90 PTS HPr component phosphorylation site K11189 - - 0.00000000000000000001393 97.0
TLS2_k127_415735_91 - - - - 0.000000000000000002516 99.0
TLS2_k127_415735_92 PTS system sorbose-specific iic component K02795 - - 0.00000000000000009724 90.0
TLS2_k127_415735_93 Cell division protein FtsQ K03589 - - 0.000000000000003588 88.0
TLS2_k127_415735_94 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000001423 74.0
TLS2_k127_415735_95 Two component signalling adaptor domain K03408 - - 0.0000000002169 68.0
TLS2_k127_415735_96 PFAM Late competence development protein ComFB K02241 - - 0.0000000006938 64.0
TLS2_k127_415735_97 PFAM Roadblock LC7 family protein - - - 0.0000000007846 66.0
TLS2_k127_415735_98 Lactonase, 7-bladed beta-propeller K07004 - - 0.000000002388 69.0
TLS2_k127_415735_99 Roadblock/LC7 domain K07131 - - 0.0000000958 58.0
TLS2_k127_4160105_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1043.0
TLS2_k127_4160105_1 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 2.655e-250 794.0
TLS2_k127_4160105_10 ABC transporter K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000008823 197.0
TLS2_k127_4160105_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000001107 182.0
TLS2_k127_4160105_12 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000001588 169.0
TLS2_k127_4160105_13 Methyltransferase domain - - - 0.00000000000000000000000000000000002125 145.0
TLS2_k127_4160105_14 - - - - 0.0000000000000000000000000000000001097 142.0
TLS2_k127_4160105_15 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000001791 143.0
TLS2_k127_4160105_16 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000001903 131.0
TLS2_k127_4160105_17 OsmC-like protein K07397 - - 0.0000000000000000000001166 102.0
TLS2_k127_4160105_18 - - - - 0.00000000000000006197 85.0
TLS2_k127_4160105_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008864 543.0
TLS2_k127_4160105_20 VKc - - - 0.000000000002035 75.0
TLS2_k127_4160105_21 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.00009894 49.0
TLS2_k127_4160105_3 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 404.0
TLS2_k127_4160105_4 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 357.0
TLS2_k127_4160105_5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000817 327.0
TLS2_k127_4160105_6 Glucose inhibited division protein A K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009989 320.0
TLS2_k127_4160105_7 Cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002348 263.0
TLS2_k127_4160105_8 CcmB protein K02194 - - 0.000000000000000000000000000000000000000000000000000000000000736 218.0
TLS2_k127_4160105_9 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000000000000000000000000000000000000000000000000003191 215.0
TLS2_k127_4176506_0 Oxidoreductase - - - 4.786e-277 865.0
TLS2_k127_4176506_1 TonB-dependent Receptor Plug Domain K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 575.0
TLS2_k127_4176506_10 Domain of unknown function (DUF4382) - - - 0.000000000000000000000000000000000000000000000000000000000000000000171 244.0
TLS2_k127_4176506_11 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000001971 237.0
TLS2_k127_4176506_12 Gluconate 2-dehydrogenase subunit 3 - - - 0.00000000000000000000000000000000000000000000000000000000005085 214.0
TLS2_k127_4176506_13 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000001115 194.0
TLS2_k127_4176506_14 serine threonine protein kinase K00870 - 2.7.1.37 0.000000000000000000000000000000000000000000000006006 190.0
TLS2_k127_4176506_15 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000005153 151.0
TLS2_k127_4176506_16 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000003202 111.0
TLS2_k127_4176506_17 Domain of unknown function DUF302 - - - 0.00000000000000000000000004059 115.0
TLS2_k127_4176506_18 DoxX - - - 0.000000000000000000007931 100.0
TLS2_k127_4176506_2 PFAM Cys Met metabolism K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 520.0
TLS2_k127_4176506_21 TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01438 - 3.5.1.16 0.0000000008135 66.0
TLS2_k127_4176506_22 NHL repeat - - - 0.0000002121 63.0
TLS2_k127_4176506_3 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 416.0
TLS2_k127_4176506_4 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 400.0
TLS2_k127_4176506_5 phosphorelay sensor kinase activity K07711,K14980,K18143 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008603 321.0
TLS2_k127_4176506_6 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 306.0
TLS2_k127_4176506_7 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003581 285.0
TLS2_k127_4176506_8 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001797 263.0
TLS2_k127_4176506_9 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000959 240.0
TLS2_k127_4198258_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1381.0
TLS2_k127_4198258_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1314.0
TLS2_k127_4198258_10 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 605.0
TLS2_k127_4198258_11 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006528 582.0
TLS2_k127_4198258_12 AAA domain K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 572.0
TLS2_k127_4198258_13 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008931 536.0
TLS2_k127_4198258_14 Hydrogenase formation hypA family K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 529.0
TLS2_k127_4198258_15 POT family K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007677 531.0
TLS2_k127_4198258_16 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 518.0
TLS2_k127_4198258_17 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 509.0
TLS2_k127_4198258_18 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 484.0
TLS2_k127_4198258_19 Putative ATP-binding cassette K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 491.0
TLS2_k127_4198258_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 5.304e-269 842.0
TLS2_k127_4198258_20 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006388 479.0
TLS2_k127_4198258_21 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 447.0
TLS2_k127_4198258_22 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 441.0
TLS2_k127_4198258_23 small subunit K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 427.0
TLS2_k127_4198258_24 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 415.0
TLS2_k127_4198258_25 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 394.0
TLS2_k127_4198258_26 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 391.0
TLS2_k127_4198258_27 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007287 379.0
TLS2_k127_4198258_28 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 382.0
TLS2_k127_4198258_29 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 366.0
TLS2_k127_4198258_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 8.357e-267 846.0
TLS2_k127_4198258_30 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 354.0
TLS2_k127_4198258_31 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 349.0
TLS2_k127_4198258_32 Phenazine biosynthesis-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 333.0
TLS2_k127_4198258_33 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 329.0
TLS2_k127_4198258_34 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 325.0
TLS2_k127_4198258_35 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 298.0
TLS2_k127_4198258_36 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000401 305.0
TLS2_k127_4198258_37 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009952 287.0
TLS2_k127_4198258_38 PFAM aminotransferase, class I K00812,K10907 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005337 282.0
TLS2_k127_4198258_39 GTP cyclohydrolase I K00950,K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000106 265.0
TLS2_k127_4198258_4 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 4.171e-263 826.0
TLS2_k127_4198258_40 Thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000915 261.0
TLS2_k127_4198258_41 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004358 252.0
TLS2_k127_4198258_42 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000007961 246.0
TLS2_k127_4198258_43 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000003674 248.0
TLS2_k127_4198258_44 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000007045 250.0
TLS2_k127_4198258_45 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.000000000000000000000000000000000000000000000000000000000000001063 226.0
TLS2_k127_4198258_46 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000002512 224.0
TLS2_k127_4198258_47 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.00000000000000000000000000000000000000000000000000000000205 213.0
TLS2_k127_4198258_48 Glycosyl transferase family 2 K08301 - - 0.0000000000000000000000000000000000000000000000000001909 194.0
TLS2_k127_4198258_49 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000002173 191.0
TLS2_k127_4198258_5 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 1.009e-227 721.0
TLS2_k127_4198258_50 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000002533 183.0
TLS2_k127_4198258_51 respiratory electron transport chain K03620 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.0000000000000000000000000000000000000000000000001251 193.0
TLS2_k127_4198258_52 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000573 183.0
TLS2_k127_4198258_53 ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component - - - 0.00000000000000000000000000000000000000000000004583 176.0
TLS2_k127_4198258_54 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000006441 176.0
TLS2_k127_4198258_55 Export-related chaperone CsaA K06878 - - 0.000000000000000000000000000000000000000000006731 175.0
TLS2_k127_4198258_56 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000002874 178.0
TLS2_k127_4198258_57 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000001865 160.0
TLS2_k127_4198258_58 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000009558 175.0
TLS2_k127_4198258_59 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000009607 157.0
TLS2_k127_4198258_6 COG0433 Predicted ATPase K06915 - - 5.178e-221 703.0
TLS2_k127_4198258_60 PFAM outer membrane efflux protein - - - 0.00000000000000000000000000000000000000009691 168.0
TLS2_k127_4198258_61 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000001143 139.0
TLS2_k127_4198258_62 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.00000000000000000000000000000000001854 141.0
TLS2_k127_4198258_63 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000008277 136.0
TLS2_k127_4198258_64 anaerobic respiration K02568 - - 0.0000000000000000000000000000006355 132.0
TLS2_k127_4198258_65 ThiS family - - - 0.00000000000000000000000000004567 118.0
TLS2_k127_4198258_66 6-pyruvoyltetrahydropterin synthase activity K01737 GO:0003674,GO:0003824,GO:0003874,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006066,GO:0006082,GO:0006520,GO:0006725,GO:0006728,GO:0006729,GO:0006732,GO:0006807,GO:0007275,GO:0007399,GO:0007417,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0019752,GO:0019889,GO:0032501,GO:0032502,GO:0034311,GO:0034312,GO:0034641,GO:0042440,GO:0042558,GO:0042559,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046146,GO:0046148,GO:0046165,GO:0046173,GO:0046483,GO:0046983,GO:0048731,GO:0048856,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.1.2.50,4.2.3.12 0.0000000000000000000000000001978 120.0
TLS2_k127_4198258_67 - - - - 0.00000000000000000000000001197 120.0
TLS2_k127_4198258_68 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000001022 123.0
TLS2_k127_4198258_69 HupF/HypC family K04653 - - 0.0000000000000000000000004487 107.0
TLS2_k127_4198258_7 Belongs to the carbamoyltransferase HypF family K04656 - - 2.348e-210 678.0
TLS2_k127_4198258_70 subunit of a heme lyase K02200 - - 0.00000000000000000000001312 115.0
TLS2_k127_4198258_71 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000003143 113.0
TLS2_k127_4198258_72 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000001326 106.0
TLS2_k127_4198258_73 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000001925 108.0
TLS2_k127_4198258_74 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006323,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0060255,GO:0065007,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141 - 0.0000000000000000000002179 102.0
TLS2_k127_4198258_75 - - - - 0.0000000000000000000003721 102.0
TLS2_k127_4198258_76 response to heat K07090 - - 0.0000000000000000000004984 101.0
TLS2_k127_4198258_77 - - - - 0.00000000000000000004813 103.0
TLS2_k127_4198258_78 DbpA RNA binding domain K05592 - 3.6.4.13 0.000000000000000000085 105.0
TLS2_k127_4198258_79 sensor histidine kinase response - - - 0.0000000000000000001703 99.0
TLS2_k127_4198258_8 FAD dependent oxidoreductase - - - 3.028e-201 643.0
TLS2_k127_4198258_80 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.0000000000000000002592 102.0
TLS2_k127_4198258_81 - - - - 0.00000000000000000823 91.0
TLS2_k127_4198258_84 Tetratricopeptide repeat - - - 0.0000000000000001259 94.0
TLS2_k127_4198258_85 Protein of unknown function (DUF721) - - - 0.000000000000002305 81.0
TLS2_k127_4198258_86 Transglutaminase/protease-like homologues - - - 0.00000000000006406 85.0
TLS2_k127_4198258_87 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000008643 81.0
TLS2_k127_4198258_88 COG1404 Subtilisin-like serine proteases K14645 GO:0005575,GO:0005576 - 0.0000000000315 76.0
TLS2_k127_4198258_89 - - - - 0.0000132 49.0
TLS2_k127_4198258_9 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 1.864e-195 646.0
TLS2_k127_4198258_90 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00003864 50.0
TLS2_k127_4198258_91 Cytochrome c7 and related cytochrome c - - - 0.00004899 56.0
TLS2_k127_4198258_93 YtxH-like protein - - - 0.0003777 48.0
TLS2_k127_4198663_0 Enoyl-(Acyl carrier protein) reductase - - - 4.385e-227 713.0
TLS2_k127_4330356_0 zinc ion binding - - - 0.00000592 59.0
TLS2_k127_4330356_1 amine dehydrogenase activity - - - 0.00002491 56.0
TLS2_k127_438448_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 488.0
TLS2_k127_438448_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000002065 188.0
TLS2_k127_438448_2 Heparinase II/III-like protein - - - 0.00000000000000000000000000000000000001346 159.0
TLS2_k127_4423603_0 serine-type peptidase activity K01278 - 3.4.14.5 1.365e-266 839.0
TLS2_k127_4423603_1 DEAD-like helicases superfamily K11927 - 3.6.4.13 1.787e-196 624.0
TLS2_k127_4423603_10 Protein of Unknown function (DUF2784) - - - 0.00006026 50.0
TLS2_k127_4423603_2 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 445.0
TLS2_k127_4423603_3 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 389.0
TLS2_k127_4423603_4 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005991 289.0
TLS2_k127_4423603_5 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000005764 156.0
TLS2_k127_4423603_6 Belongs to the P(II) protein family - - - 0.000000000000000000000000000000000000005897 147.0
TLS2_k127_4423603_7 Fic/DOC family K07341 - - 0.00000000000000000002873 95.0
TLS2_k127_4423603_8 carboxylic ester hydrolase activity - - - 0.00000000002295 75.0
TLS2_k127_4423603_9 PFAM SpoVT AbrB - - - 0.000009081 50.0
TLS2_k127_4489427_0 Tetratricopeptide repeat K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 556.0
TLS2_k127_4489427_1 Periplasmic sensor domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 370.0
TLS2_k127_4489427_10 methylamine metabolic process K15977 - - 0.0000000000003304 76.0
TLS2_k127_4489427_11 - - - - 0.00009621 53.0
TLS2_k127_4489427_2 receptor K02014,K16089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 347.0
TLS2_k127_4489427_3 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000008678 256.0
TLS2_k127_4489427_4 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000000001941 225.0
TLS2_k127_4489427_5 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000001456 214.0
TLS2_k127_4489427_6 Zn peptidase - - - 0.0000000000000000000000000000000000000000000000000000000003283 219.0
TLS2_k127_4489427_7 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000003658 190.0
TLS2_k127_4489427_8 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000004667 191.0
TLS2_k127_4489427_9 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.000000000000000000000000000000000000000000000002005 186.0
TLS2_k127_4510961_0 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 414.0
TLS2_k127_4510961_1 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000002998 199.0
TLS2_k127_4510961_2 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000001049 157.0
TLS2_k127_4510961_3 PFAM Helix-turn-helix - - - 0.0000000000000000001012 90.0
TLS2_k127_4560041_0 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 337.0
TLS2_k127_4560041_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000001363 163.0
TLS2_k127_4560041_2 peptide deformylase activity K01462 - 3.5.1.88 0.0000000000008281 70.0
TLS2_k127_4708487_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000329 358.0
TLS2_k127_4708487_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 343.0
TLS2_k127_4708487_10 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000001602 90.0
TLS2_k127_4708487_11 - - - - 0.0000000000000000005715 91.0
TLS2_k127_4708487_12 - - - - 0.000000000000000004605 89.0
TLS2_k127_4708487_13 Protein of unknown function (DUF2283) - - - 0.000000000000004681 82.0
TLS2_k127_4708487_14 lactoylglutathione lyase activity - - - 0.00000000005158 71.0
TLS2_k127_4708487_15 - - - - 0.000000003286 67.0
TLS2_k127_4708487_2 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000002731 219.0
TLS2_k127_4708487_3 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000001245 231.0
TLS2_k127_4708487_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000001197 173.0
TLS2_k127_4708487_5 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000008073 150.0
TLS2_k127_4708487_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000003192 133.0
TLS2_k127_4708487_8 mRNA binding - - - 0.0000000000000000000000000000074 119.0
TLS2_k127_4708487_9 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000002922 100.0
TLS2_k127_4862881_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.555e-232 738.0
TLS2_k127_4862881_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 597.0
TLS2_k127_4862881_10 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 477.0
TLS2_k127_4862881_11 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006783 468.0
TLS2_k127_4862881_12 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 451.0
TLS2_k127_4862881_13 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 444.0
TLS2_k127_4862881_14 DAHP synthetase I family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 441.0
TLS2_k127_4862881_15 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 441.0
TLS2_k127_4862881_16 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009254 431.0
TLS2_k127_4862881_17 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006187 418.0
TLS2_k127_4862881_18 Phosphoglucose isomerase K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 414.0
TLS2_k127_4862881_19 FAD binding domain K00486 - 1.14.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000928 400.0
TLS2_k127_4862881_2 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005991 584.0
TLS2_k127_4862881_20 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 382.0
TLS2_k127_4862881_21 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 391.0
TLS2_k127_4862881_22 Aminotransferase class-V K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 387.0
TLS2_k127_4862881_23 Competence-damaged protein K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 385.0
TLS2_k127_4862881_24 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000834 377.0
TLS2_k127_4862881_25 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 366.0
TLS2_k127_4862881_26 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 396.0
TLS2_k127_4862881_27 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 351.0
TLS2_k127_4862881_28 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008775 364.0
TLS2_k127_4862881_29 Tryptophan 2,3-dioxygenase K00453 - 1.13.11.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 336.0
TLS2_k127_4862881_3 Fructose-bisphosphate aldolase class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003777 561.0
TLS2_k127_4862881_30 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 321.0
TLS2_k127_4862881_31 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 319.0
TLS2_k127_4862881_32 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 300.0
TLS2_k127_4862881_33 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 298.0
TLS2_k127_4862881_34 4-hydroxy-2-oxoglutarate aldolase K18123 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006081,GO:0006082,GO:0006090,GO:0006520,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008700,GO:0009056,GO:0009058,GO:0009063,GO:0009436,GO:0009987,GO:0016053,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0016833,GO:0019470,GO:0019471,GO:0019752,GO:0031974,GO:0032787,GO:0033609,GO:0042219,GO:0042802,GO:0042803,GO:0042866,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046185,GO:0046394,GO:0046395,GO:0046487,GO:0046983,GO:0070013,GO:0071704,GO:0072329,GO:0072330,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606 4.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 300.0
TLS2_k127_4862881_35 Belongs to the aldehyde dehydrogenase family K00130,K00151,K10217 GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0008802,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003583 280.0
TLS2_k127_4862881_36 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006184 275.0
TLS2_k127_4862881_37 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000069 256.0
TLS2_k127_4862881_38 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005034 249.0
TLS2_k127_4862881_39 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.000000000000000000000000000000000000000000000000000000000000008788 224.0
TLS2_k127_4862881_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007719 528.0
TLS2_k127_4862881_40 COG0512 Anthranilate para-aminobenzoate synthases component II K01658 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 0.000000000000000000000000000000000000000000000000000000001528 207.0
TLS2_k127_4862881_41 Translation initiation inhibitor, yjgF family K15067 - 3.5.99.5 0.000000000000000000000000000000000000000000000000000000005976 205.0
TLS2_k127_4862881_42 Roadblock/LC7 domain - - - 0.000000000000000000000000000000000000000000000000000114 191.0
TLS2_k127_4862881_43 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000004776 181.0
TLS2_k127_4862881_44 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000932 159.0
TLS2_k127_4862881_45 PFAM membrane protein of K08972 - - 0.00000000000000000000000000000004457 132.0
TLS2_k127_4862881_46 Putative restriction endonuclease - - - 0.000000000000000000000000000004999 128.0
TLS2_k127_4862881_47 domain, Protein - - - 0.000000000000000000000000000282 133.0
TLS2_k127_4862881_48 Thioredoxin-like - - - 0.0000000000000000000000000007714 128.0
TLS2_k127_4862881_49 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000002132 112.0
TLS2_k127_4862881_5 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 505.0
TLS2_k127_4862881_50 Outer membrane protein beta-barrel domain - - - 0.00000000000000000008156 98.0
TLS2_k127_4862881_51 - - - - 0.0000000000002768 75.0
TLS2_k127_4862881_52 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000002485 71.0
TLS2_k127_4862881_53 YtxH-like protein - - - 0.0000001656 58.0
TLS2_k127_4862881_54 membrane K07058 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000001378 59.0
TLS2_k127_4862881_55 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.00000364 58.0
TLS2_k127_4862881_6 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 506.0
TLS2_k127_4862881_7 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 507.0
TLS2_k127_4862881_8 Aminotransferase class-V K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 500.0
TLS2_k127_4862881_9 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 485.0
TLS2_k127_4872466_0 - - - - 0.0000000000000000001534 103.0
TLS2_k127_4872466_1 PAS modulated sigma54 specific transcriptional regulator, Fis family - - - 0.000001086 57.0
TLS2_k127_4894260_0 DNA polymerase III alpha subunit K02337,K14162 - 2.7.7.7 6.911e-241 779.0
TLS2_k127_4894260_1 PFAM Adenosine AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 447.0
TLS2_k127_4894260_11 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000003628 186.0
TLS2_k127_4894260_12 translation initiation inhibitor, yjgF family - - - 0.000000000000000000000000000000000000000000000000005141 186.0
TLS2_k127_4894260_13 - - - - 0.0000000000000000000000000000000000000000000000001757 184.0
TLS2_k127_4894260_14 Domain of unknown function (DUF4142) - - - 0.000000000000000000000000000000000000000000000007977 181.0
TLS2_k127_4894260_15 Cupin domain - - - 0.000000000000000000000000000000000000000000003129 174.0
TLS2_k127_4894260_16 DNA-directed DNA polymerase K02346 - 2.7.7.7 0.000000000000000000000000000000000000000004749 170.0
TLS2_k127_4894260_17 - - - - 0.000000000000000000000000000000000000007725 158.0
TLS2_k127_4894260_18 methyltransferase activity - - - 0.00000000000000000000000000000002976 138.0
TLS2_k127_4894260_19 - - - - 0.0000000000000007696 82.0
TLS2_k127_4894260_2 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 422.0
TLS2_k127_4894260_21 Glyoxalase-like domain - - - 0.00000001439 64.0
TLS2_k127_4894260_23 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000957 46.0
TLS2_k127_4894260_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 389.0
TLS2_k127_4894260_4 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 325.0
TLS2_k127_4894260_5 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002929 272.0
TLS2_k127_4894260_6 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006346 256.0
TLS2_k127_4894260_7 EXOIII K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000009994 262.0
TLS2_k127_4894260_8 translation initiation factor activity K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000000001394 239.0
TLS2_k127_4894260_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000005028 233.0
TLS2_k127_4903761_0 Imidazolonepropionase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 506.0
TLS2_k127_4903761_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000003313 213.0
TLS2_k127_4903761_2 - - - - 0.000000000000239 75.0
TLS2_k127_4937332_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 5.369e-225 710.0
TLS2_k127_4937332_1 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 611.0
TLS2_k127_4937332_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006008 402.0
TLS2_k127_4937332_3 ketosteroid isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 313.0
TLS2_k127_4937332_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.00000000000000000000000000000000000000000000000000000000000000000008896 247.0
TLS2_k127_4937332_5 tungstate binding K15495 - - 0.000000000000000000000000000000000000000000000000000000000000000000424 240.0
TLS2_k127_4937332_6 Divalent ion tolerance protein K03926 - - 0.000000000000000000000000001711 115.0
TLS2_k127_4937332_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000001704 95.0
TLS2_k127_4950366_0 Group II intron, maturase-specific domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 569.0
TLS2_k127_5084222_0 Transposase IS200 like - - - 0.000000000000000000000002044 109.0
TLS2_k127_509756_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 5.108e-279 870.0
TLS2_k127_509756_1 HELICc2 K03722 - 3.6.4.12 2.115e-273 868.0
TLS2_k127_509756_10 Acyl-CoA dehydrogenase, N-terminal domain - - - 4.541e-210 671.0
TLS2_k127_509756_100 Cold shock K03704 - - 0.0000000000000000000000000000904 119.0
TLS2_k127_509756_101 - - - - 0.0000000000000000000000000002001 127.0
TLS2_k127_509756_102 Sporulation related domain - - - 0.0000000000000000000000000005975 130.0
TLS2_k127_509756_103 LemA family K03744 - - 0.000000000000000000000000006422 121.0
TLS2_k127_509756_104 Pyridoxamine 5'-phosphate oxidase like - - - 0.000000000000000000000000008395 124.0
TLS2_k127_509756_105 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.00000000000000000000000003569 120.0
TLS2_k127_509756_106 50S ribosomal protein L31 K02909 - - 0.00000000000000000000000006123 108.0
TLS2_k127_509756_107 Protein of unknown function (DUF456) K09793 - - 0.0000000000000000000000001574 111.0
TLS2_k127_509756_108 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000007366 105.0
TLS2_k127_509756_109 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division K20543 - - 0.000000000000000000000001868 119.0
TLS2_k127_509756_11 Penicillin amidase K01434 - 3.5.1.11 2.41e-208 676.0
TLS2_k127_509756_110 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000001003 106.0
TLS2_k127_509756_111 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000002366 102.0
TLS2_k127_509756_112 amidohydrolase - - - 0.0000000000000000000002637 103.0
TLS2_k127_509756_113 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000002296 104.0
TLS2_k127_509756_114 - - - - 0.00000000000000000002963 97.0
TLS2_k127_509756_115 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000341 98.0
TLS2_k127_509756_116 - - - - 0.0000000000000000008713 87.0
TLS2_k127_509756_117 - - - - 0.000000000000000002195 99.0
TLS2_k127_509756_118 Control of competence regulator ComK, YlbF/YmcA - - - 0.00000000000000005839 87.0
TLS2_k127_509756_119 response to heat K03668 - - 0.000000000001059 76.0
TLS2_k127_509756_12 Aldehyde dehydrogenase family K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 9.785e-199 629.0
TLS2_k127_509756_120 - - - - 0.000000000001416 79.0
TLS2_k127_509756_122 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000005874 74.0
TLS2_k127_509756_123 - - - - 0.00000000006326 69.0
TLS2_k127_509756_124 - - - - 0.00000000187 71.0
TLS2_k127_509756_125 Serine aminopeptidase, S33 - - - 0.000000002217 63.0
TLS2_k127_509756_126 - - - - 0.000000005571 67.0
TLS2_k127_509756_127 PIN domain - - - 0.000000006353 64.0
TLS2_k127_509756_128 Curli production assembly/transport component CsgG - - - 0.00000005281 63.0
TLS2_k127_509756_129 metal-dependent membrane protease - - - 0.0000002389 63.0
TLS2_k127_509756_13 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000868 627.0
TLS2_k127_509756_130 domain, Protein - - - 0.000004111 59.0
TLS2_k127_509756_131 Peptidoglycan binding domain - - - 0.000005797 56.0
TLS2_k127_509756_132 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000006086 52.0
TLS2_k127_509756_133 helix_turn_helix multiple antibiotic resistance protein - - - 0.000006774 55.0
TLS2_k127_509756_134 Anti-sigma-K factor rskA - - - 0.0000201 55.0
TLS2_k127_509756_136 nuclease activity - - - 0.0001707 49.0
TLS2_k127_509756_14 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 613.0
TLS2_k127_509756_15 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006913 544.0
TLS2_k127_509756_16 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 531.0
TLS2_k127_509756_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007971 523.0
TLS2_k127_509756_18 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 492.0
TLS2_k127_509756_19 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000804 475.0
TLS2_k127_509756_2 Required for chromosome condensation and partitioning K03529 - - 3.043e-270 872.0
TLS2_k127_509756_20 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 473.0
TLS2_k127_509756_21 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006937 463.0
TLS2_k127_509756_22 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 447.0
TLS2_k127_509756_23 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 439.0
TLS2_k127_509756_24 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 431.0
TLS2_k127_509756_25 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 423.0
TLS2_k127_509756_26 alcohol dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008058 426.0
TLS2_k127_509756_27 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 435.0
TLS2_k127_509756_28 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003268 430.0
TLS2_k127_509756_29 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 415.0
TLS2_k127_509756_3 Aldehyde dehydrogenase family K22187 - - 6.171e-262 819.0
TLS2_k127_509756_30 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 415.0
TLS2_k127_509756_31 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 391.0
TLS2_k127_509756_32 PFAM Peptidase family M20 M25 M40 K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 379.0
TLS2_k127_509756_33 Anaphase-promoting complex subunit 5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 377.0
TLS2_k127_509756_34 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 344.0
TLS2_k127_509756_35 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 341.0
TLS2_k127_509756_36 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005287 323.0
TLS2_k127_509756_37 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 326.0
TLS2_k127_509756_38 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 326.0
TLS2_k127_509756_39 Dihydroxyacetone kinase family K07030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 332.0
TLS2_k127_509756_4 Involved in the tonB-independent uptake of proteins - - - 1.198e-245 794.0
TLS2_k127_509756_40 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 318.0
TLS2_k127_509756_41 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004802 312.0
TLS2_k127_509756_42 Homoserine dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 324.0
TLS2_k127_509756_43 nuclear chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 345.0
TLS2_k127_509756_44 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 309.0
TLS2_k127_509756_45 PFAM CBS domain containing protein K06402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 311.0
TLS2_k127_509756_46 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 296.0
TLS2_k127_509756_47 PFAM regulator of chromosome condensation, RCC1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 304.0
TLS2_k127_509756_48 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000688 297.0
TLS2_k127_509756_49 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000354 289.0
TLS2_k127_509756_5 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 4.77e-244 772.0
TLS2_k127_509756_50 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001311 284.0
TLS2_k127_509756_51 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001868 278.0
TLS2_k127_509756_52 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000828 250.0
TLS2_k127_509756_53 Belongs to the UPF0271 (lamB) family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001424 260.0
TLS2_k127_509756_54 Part of the ABC transporter complex WtpABC involved in molybdate tungstate import. Responsible for energy coupling to the transport system (By similarity) K02017,K02062,K15497 - 3.6.3.29,3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000001235 262.0
TLS2_k127_509756_55 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000004087 236.0
TLS2_k127_509756_56 ATPase-coupled sulfate transmembrane transporter activity K15496 - - 0.0000000000000000000000000000000000000000000000000000000000000009442 227.0
TLS2_k127_509756_57 Amidinotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000002295 226.0
TLS2_k127_509756_58 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000008405 212.0
TLS2_k127_509756_59 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000000000000002948 218.0
TLS2_k127_509756_6 Amidohydrolase family K06015 - 3.5.1.81 4.902e-244 771.0
TLS2_k127_509756_60 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000000000000000000000000000000000000000000000000000004727 209.0
TLS2_k127_509756_61 Allophanate hydrolase subunit 2 K06350 - - 0.000000000000000000000000000000000000000000000000000000008294 210.0
TLS2_k127_509756_62 Methyltransferase small domain K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000891 211.0
TLS2_k127_509756_63 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000008696 211.0
TLS2_k127_509756_64 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 0.000000000000000000000000000000000000000000000000000001393 201.0
TLS2_k127_509756_65 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000009836 190.0
TLS2_k127_509756_66 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000007396 203.0
TLS2_k127_509756_67 Pfam Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000003507 200.0
TLS2_k127_509756_68 NAD(P)H-binding K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000003596 192.0
TLS2_k127_509756_69 Allophanate hydrolase subunit 1 - - - 0.00000000000000000000000000000000000000000000000006599 189.0
TLS2_k127_509756_7 4Fe-4S dicluster domain K00184 - - 1.045e-233 756.0
TLS2_k127_509756_70 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000002617 191.0
TLS2_k127_509756_71 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000002817 185.0
TLS2_k127_509756_72 MOSC domain - - - 0.000000000000000000000000000000000000000000000009505 180.0
TLS2_k127_509756_73 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000001725 178.0
TLS2_k127_509756_74 YjbR - - - 0.00000000000000000000000000000000000000000000002105 173.0
TLS2_k127_509756_75 Cupin domain - - - 0.00000000000000000000000000000000000000000000005759 174.0
TLS2_k127_509756_76 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000007854 175.0
TLS2_k127_509756_77 Iron-storage protein K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000009587 175.0
TLS2_k127_509756_78 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000267 172.0
TLS2_k127_509756_79 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000004111 164.0
TLS2_k127_509756_8 ABC transporter transmembrane region K11085 - - 9.209e-233 755.0
TLS2_k127_509756_80 PFAM peptidase M6, immune inhibitor A - - - 0.0000000000000000000000000000000000000000191 175.0
TLS2_k127_509756_81 - - - - 0.0000000000000000000000000000000000000006141 164.0
TLS2_k127_509756_82 GGDEF domain - - - 0.000000000000000000000000000000000000003866 164.0
TLS2_k127_509756_83 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000003897 149.0
TLS2_k127_509756_84 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000007575 157.0
TLS2_k127_509756_85 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000001435 148.0
TLS2_k127_509756_86 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000001751 152.0
TLS2_k127_509756_87 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000002249 153.0
TLS2_k127_509756_88 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000009982 157.0
TLS2_k127_509756_89 - - - - 0.0000000000000000000000000000000000001624 154.0
TLS2_k127_509756_9 Peptidase family M3 K08602 - - 3.296e-211 670.0
TLS2_k127_509756_90 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000002293 154.0
TLS2_k127_509756_91 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000002562 143.0
TLS2_k127_509756_92 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.00000000000000000000000000000000004575 140.0
TLS2_k127_509756_93 PFAM conserved K07027 - - 0.000000000000000000000000000000000142 145.0
TLS2_k127_509756_94 Cold shock K03704 - - 0.0000000000000000000000000000000002928 132.0
TLS2_k127_509756_95 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000003187 132.0
TLS2_k127_509756_96 PFAM Bacterial regulatory proteins, tetR family K09017,K22295 - - 0.00000000000000000000000000000118 130.0
TLS2_k127_509756_97 RF-1 domain K15034 - - 0.000000000000000000000000000001764 126.0
TLS2_k127_509756_98 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000009202 124.0
TLS2_k127_509756_99 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000005773 124.0
TLS2_k127_5131572_0 FtsX-like permease family K02004 - - 3.173e-194 638.0
TLS2_k127_5131572_1 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 283.0
TLS2_k127_5131572_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000005377 236.0
TLS2_k127_5131572_3 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000001465 216.0
TLS2_k127_5131572_4 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000002133 193.0
TLS2_k127_5131572_5 filamentous hemagglutinin family N-terminal domain - - - 0.00000002058 68.0
TLS2_k127_5149502_0 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 447.0
TLS2_k127_5149502_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 304.0
TLS2_k127_5149502_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000001256 96.0
TLS2_k127_5149502_3 Flavodoxin-like fold - - - 0.000000000000009825 78.0
TLS2_k127_5149502_4 Protein kinase domain K12132 - 2.7.11.1 0.00000000002181 68.0
TLS2_k127_5149502_5 efflux transmembrane transporter activity - - - 0.00085 45.0
TLS2_k127_5193145_0 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006592 436.0
TLS2_k127_5193145_1 Secretion protein K01993 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 294.0
TLS2_k127_5193145_2 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000002186 190.0
TLS2_k127_5193145_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000002149 93.0
TLS2_k127_5193145_4 RND efflux system, outer membrane lipoprotein K18903 - - 0.00006452 55.0
TLS2_k127_5411432_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 294.0
TLS2_k127_5411432_1 PFAM ATP-binding region, ATPase domain protein K07636 - 2.7.13.3 0.0000000000000000000000007366 105.0
TLS2_k127_5427266_0 efflux transmembrane transporter activity - - - 1.83e-306 963.0
TLS2_k127_5427266_1 histidine kinase A domain protein - - - 5.817e-246 800.0
TLS2_k127_5427266_10 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 460.0
TLS2_k127_5427266_11 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 467.0
TLS2_k127_5427266_12 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008274 441.0
TLS2_k127_5427266_13 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 450.0
TLS2_k127_5427266_14 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 397.0
TLS2_k127_5427266_15 Dihydroorotate dehydrogenase K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 403.0
TLS2_k127_5427266_16 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009361 377.0
TLS2_k127_5427266_17 topoisomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 376.0
TLS2_k127_5427266_18 Dihydropyrimidinase K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 374.0
TLS2_k127_5427266_19 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 357.0
TLS2_k127_5427266_2 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 7.311e-228 715.0
TLS2_k127_5427266_20 PFAM ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005824 336.0
TLS2_k127_5427266_21 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006088 323.0
TLS2_k127_5427266_22 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 317.0
TLS2_k127_5427266_23 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 294.0
TLS2_k127_5427266_24 PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007654 265.0
TLS2_k127_5427266_25 Erythromycin esterase K06880 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003152 259.0
TLS2_k127_5427266_26 heme binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000001572 265.0
TLS2_k127_5427266_27 Putative esterase K07017 - - 0.0000000000000000000000000000000000000000000000000000000000000000005443 239.0
TLS2_k127_5427266_28 acetyltransferase - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 - 0.000000000000000000000000000000000000000000000000000000000000001184 223.0
TLS2_k127_5427266_29 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000000000000000000000027 233.0
TLS2_k127_5427266_3 ABC1 family K03688 - - 7.458e-215 681.0
TLS2_k127_5427266_30 CHRD domain - - - 0.0000000000000000000000000000000000000000000000000001599 191.0
TLS2_k127_5427266_31 PRC-barrel domain - - - 0.00000000000000000000000000000000000000002379 155.0
TLS2_k127_5427266_32 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000003899 152.0
TLS2_k127_5427266_33 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000004117 163.0
TLS2_k127_5427266_34 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000001527 161.0
TLS2_k127_5427266_35 glyoxalase III activity - - - 0.0000000000000000000000000000000000004265 147.0
TLS2_k127_5427266_36 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000003542 142.0
TLS2_k127_5427266_37 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000003576 139.0
TLS2_k127_5427266_38 2 iron, 2 sulfur cluster binding K13643 - - 0.000000000000000000000000000006211 124.0
TLS2_k127_5427266_39 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000001804 116.0
TLS2_k127_5427266_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 8.78e-215 680.0
TLS2_k127_5427266_42 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000141 102.0
TLS2_k127_5427266_43 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000002177 101.0
TLS2_k127_5427266_44 Antirepressor regulating drug resistance - - - 0.0000000000000007062 91.0
TLS2_k127_5427266_45 Penicillinase repressor - - - 0.0000000000000194 80.0
TLS2_k127_5427266_46 - - - - 0.00000000002176 75.0
TLS2_k127_5427266_47 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000008013 68.0
TLS2_k127_5427266_48 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000002692 53.0
TLS2_k127_5427266_49 NHL repeat containing protein - - - 0.00002481 56.0
TLS2_k127_5427266_5 permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 1.035e-194 620.0
TLS2_k127_5427266_50 Protein of unknown function (DUF1579) - - - 0.0001061 54.0
TLS2_k127_5427266_51 FERM N-terminal domain K06107 GO:0001700,GO:0002009,GO:0002165,GO:0003002,GO:0003007,GO:0003008,GO:0003013,GO:0003015,GO:0003674,GO:0005198,GO:0005200,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0005911,GO:0005918,GO:0005920,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0006996,GO:0007010,GO:0007043,GO:0007155,GO:0007163,GO:0007275,GO:0007389,GO:0007391,GO:0007399,GO:0007424,GO:0007431,GO:0007435,GO:0007444,GO:0007472,GO:0007476,GO:0007507,GO:0007525,GO:0007527,GO:0007552,GO:0007560,GO:0008092,GO:0008104,GO:0008150,GO:0008362,GO:0008544,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009888,GO:0009913,GO:0009954,GO:0009987,GO:0010001,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016331,GO:0019991,GO:0021782,GO:0022008,GO:0022607,GO:0022610,GO:0022612,GO:0030029,GO:0030030,GO:0030036,GO:0030054,GO:0030154,GO:0030182,GO:0030855,GO:0031032,GO:0032501,GO:0032502,GO:0033036,GO:0034329,GO:0034330,GO:0034613,GO:0035107,GO:0035114,GO:0035120,GO:0035150,GO:0035151,GO:0035152,GO:0035220,GO:0035239,GO:0035272,GO:0035295,GO:0035315,GO:0035316,GO:0035317,GO:0035321,GO:0040003,GO:0042063,GO:0042335,GO:0042886,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043296,GO:0043297,GO:0044085,GO:0044424,GO:0044464,GO:0045184,GO:0045216,GO:0046907,GO:0048468,GO:0048513,GO:0048563,GO:0048569,GO:0048598,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048732,GO:0048736,GO:0048737,GO:0048856,GO:0048869,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060429,GO:0060541,GO:0060562,GO:0060856,GO:0060857,GO:0061061,GO:0061343,GO:0065007,GO:0065008,GO:0070160,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072359,GO:0072657,GO:0090066,GO:0090150,GO:0120036 - 0.0006382 49.0
TLS2_k127_5427266_6 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 562.0
TLS2_k127_5427266_7 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009632 546.0
TLS2_k127_5427266_8 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 533.0
TLS2_k127_5427266_9 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 469.0
TLS2_k127_5455073_0 Tricorn protease homolog - - - 0.0 1195.0
TLS2_k127_5455073_1 protein import - - - 1.124e-295 932.0
TLS2_k127_5455073_2 Histidine kinase K02282,K02482,K03557 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 488.0
TLS2_k127_5455073_3 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002578 263.0
TLS2_k127_5608405_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 5.019e-208 664.0
TLS2_k127_5608405_1 MMPL family K06994 - - 0.00000000000000000000000000000008318 126.0
TLS2_k127_5665459_1 DNA ligase K01971 - 6.5.1.1 0.000000003829 61.0
TLS2_k127_5665459_2 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.000000008057 58.0
TLS2_k127_5674444_0 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 6.159e-271 855.0
TLS2_k127_5674444_1 lysine biosynthetic process via aminoadipic acid - - - 3.073e-230 743.0
TLS2_k127_5674444_10 - - - - 0.0000000000000000000000000000000000000000000001486 179.0
TLS2_k127_5674444_11 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000009719 166.0
TLS2_k127_5674444_12 Domain of unknown function (DUF1877) - - - 0.00000000000000000000000000000000000005009 151.0
TLS2_k127_5674444_13 Putative lumazine-binding - - - 0.00000000000000000000000000000000004746 141.0
TLS2_k127_5674444_2 Fumarylacetoacetate (FAA) hydrolase K01555 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 584.0
TLS2_k127_5674444_3 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008457 500.0
TLS2_k127_5674444_4 Peptidase family M23 K21472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006548 318.0
TLS2_k127_5674444_5 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 304.0
TLS2_k127_5674444_6 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 297.0
TLS2_k127_5674444_7 trehalose utilisation K08738,K09992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005027 280.0
TLS2_k127_5674444_8 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000122 248.0
TLS2_k127_5674444_9 histidine-tRNA ligase activity K01892,K02502 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000003428 222.0
TLS2_k127_5684511_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000002297 241.0
TLS2_k127_5684511_1 - - - - 0.00000001356 67.0
TLS2_k127_5747540_0 Putative metal-binding domain of cation transport ATPase K01533 - 3.6.3.4 1.107e-290 912.0
TLS2_k127_5747540_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 548.0
TLS2_k127_5747540_2 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 482.0
TLS2_k127_5747540_3 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.0000000000000000000000000000000000000000000000000000000000000209 221.0
TLS2_k127_5747540_4 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.00000000000000000000000000000000000000000000000000000000009801 215.0
TLS2_k127_5747540_5 FixH - - - 0.00000000000000000000000000000007656 133.0
TLS2_k127_5747540_6 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.000000006336 59.0
TLS2_k127_5779032_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1052.0
TLS2_k127_5779032_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.626e-259 819.0
TLS2_k127_5779032_10 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 559.0
TLS2_k127_5779032_11 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 546.0
TLS2_k127_5779032_12 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 536.0
TLS2_k127_5779032_13 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 527.0
TLS2_k127_5779032_14 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 507.0
TLS2_k127_5779032_15 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 504.0
TLS2_k127_5779032_16 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 509.0
TLS2_k127_5779032_17 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 503.0
TLS2_k127_5779032_18 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 492.0
TLS2_k127_5779032_19 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 490.0
TLS2_k127_5779032_2 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 5.774e-253 791.0
TLS2_k127_5779032_20 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 491.0
TLS2_k127_5779032_21 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 486.0
TLS2_k127_5779032_22 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 468.0
TLS2_k127_5779032_23 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007089 457.0
TLS2_k127_5779032_24 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 441.0
TLS2_k127_5779032_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005437 445.0
TLS2_k127_5779032_26 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 448.0
TLS2_k127_5779032_27 UPF0365 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 436.0
TLS2_k127_5779032_28 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 432.0
TLS2_k127_5779032_29 4Fe-4S ferredoxin iron-sulfur binding domain protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 398.0
TLS2_k127_5779032_3 Carboxyl transferase domain - - - 1.542e-251 788.0
TLS2_k127_5779032_30 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 387.0
TLS2_k127_5779032_31 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 390.0
TLS2_k127_5779032_32 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 379.0
TLS2_k127_5779032_33 SIS domain K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 378.0
TLS2_k127_5779032_34 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 389.0
TLS2_k127_5779032_35 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 355.0
TLS2_k127_5779032_36 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 350.0
TLS2_k127_5779032_37 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 370.0
TLS2_k127_5779032_38 RecQ zinc-binding K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 362.0
TLS2_k127_5779032_39 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 357.0
TLS2_k127_5779032_4 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 1.132e-226 721.0
TLS2_k127_5779032_40 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 338.0
TLS2_k127_5779032_41 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 323.0
TLS2_k127_5779032_42 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 320.0
TLS2_k127_5779032_43 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 317.0
TLS2_k127_5779032_44 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 304.0
TLS2_k127_5779032_45 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 302.0
TLS2_k127_5779032_46 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 307.0
TLS2_k127_5779032_47 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 292.0
TLS2_k127_5779032_48 Membrane-bound serine protease (ClpP class) K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 304.0
TLS2_k127_5779032_49 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009648 297.0
TLS2_k127_5779032_5 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 1.019e-206 658.0
TLS2_k127_5779032_50 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 289.0
TLS2_k127_5779032_51 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005827 278.0
TLS2_k127_5779032_52 Belongs to the peptidase S8 family K01280 - 3.4.14.10 0.0000000000000000000000000000000000000000000000000000000000000000000000001393 280.0
TLS2_k127_5779032_53 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000002383 244.0
TLS2_k127_5779032_54 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000002766 244.0
TLS2_k127_5779032_55 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000003618 238.0
TLS2_k127_5779032_56 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000001643 241.0
TLS2_k127_5779032_57 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000002449 220.0
TLS2_k127_5779032_58 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000009521 224.0
TLS2_k127_5779032_59 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000034 234.0
TLS2_k127_5779032_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 2.365e-206 649.0
TLS2_k127_5779032_60 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000000000000000000000004971 210.0
TLS2_k127_5779032_61 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000007536 209.0
TLS2_k127_5779032_62 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000421 214.0
TLS2_k127_5779032_63 NDK K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000001195 192.0
TLS2_k127_5779032_64 - K00241 - - 0.0000000000000000000000000000000000000000000000000002316 194.0
TLS2_k127_5779032_65 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000127 189.0
TLS2_k127_5779032_66 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.0000000000000000000000000000000000000000000000001513 191.0
TLS2_k127_5779032_67 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000004306 188.0
TLS2_k127_5779032_68 TIGR00255 family - - - 0.0000000000000000000000000000000000000000000000006738 190.0
TLS2_k127_5779032_69 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000009595 179.0
TLS2_k127_5779032_7 Acyclic terpene utilisation family protein AtuA - - - 3.89e-203 641.0
TLS2_k127_5779032_70 Transporter associated domain K06189 - - 0.00000000000000000000000000000000000000000000007872 185.0
TLS2_k127_5779032_71 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000001444 166.0
TLS2_k127_5779032_72 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.00000000000000000000000000000000000000000005393 163.0
TLS2_k127_5779032_73 - - - - 0.0000000000000000000000000000000000000000004056 167.0
TLS2_k127_5779032_74 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000002006 172.0
TLS2_k127_5779032_75 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000001605 147.0
TLS2_k127_5779032_76 MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000000002575 141.0
TLS2_k127_5779032_77 Ribosomal L27 protein K02899 - - 0.0000000000000000000000000000000001718 133.0
TLS2_k127_5779032_78 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000001705 132.0
TLS2_k127_5779032_79 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000001972 126.0
TLS2_k127_5779032_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 619.0
TLS2_k127_5779032_80 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000003122 129.0
TLS2_k127_5779032_81 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000578 125.0
TLS2_k127_5779032_82 competence protein - - - 0.000000000000000000000000000002069 136.0
TLS2_k127_5779032_83 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000007762 129.0
TLS2_k127_5779032_84 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000005978 124.0
TLS2_k127_5779032_85 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000032 115.0
TLS2_k127_5779032_86 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000001509 115.0
TLS2_k127_5779032_87 SNARE associated Golgi protein - - - 0.0000000000000000000000001553 122.0
TLS2_k127_5779032_88 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000003213 108.0
TLS2_k127_5779032_89 TonB-dependent Receptor Plug Domain - - - 0.00000000000002237 87.0
TLS2_k127_5779032_9 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003831 575.0
TLS2_k127_5779032_90 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000007439 73.0
TLS2_k127_5779032_91 Preprotein translocase SecG subunit K03075 - - 0.0000000000004822 74.0
TLS2_k127_5779032_92 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.000000000001261 72.0
TLS2_k127_5779032_93 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000003116 80.0
TLS2_k127_5779032_94 ThiS family K03636 - - 0.0000000001861 66.0
TLS2_k127_5779032_95 - - - - 0.0000001343 61.0
TLS2_k127_5779032_96 6-phosphogluconolactonase activity - - - 0.00004874 57.0
TLS2_k127_5786248_0 metallocarboxypeptidase activity - - - 5.405e-255 814.0
TLS2_k127_5786248_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 562.0
TLS2_k127_5786248_10 - - - - 0.00000000000000000000000000000000000000000000004374 181.0
TLS2_k127_5786248_11 - - - - 0.000000000000000000000000000000000000003966 162.0
TLS2_k127_5786248_12 PFAM small multidrug resistance protein K11741 - - 0.000000000000000000000000000000000000005314 148.0
TLS2_k127_5786248_13 FR47-like protein K18816 - 2.3.1.82 0.000000000000000000000000000000000000007168 149.0
TLS2_k127_5786248_14 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000000002361 135.0
TLS2_k127_5786248_15 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000007034 108.0
TLS2_k127_5786248_16 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000005249 82.0
TLS2_k127_5786248_17 response to heat K03668,K09914 - - 0.000000000009089 76.0
TLS2_k127_5786248_18 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000002898 66.0
TLS2_k127_5786248_19 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000057 64.0
TLS2_k127_5786248_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 513.0
TLS2_k127_5786248_20 - - - - 0.00000007123 61.0
TLS2_k127_5786248_3 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 488.0
TLS2_k127_5786248_4 PFAM V-type ATPase 116 kDa K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 336.0
TLS2_k127_5786248_5 Sodium:dicarboxylate symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 317.0
TLS2_k127_5786248_6 COG0778 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 302.0
TLS2_k127_5786248_7 membrane K07148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002596 274.0
TLS2_k127_5786248_8 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001104 228.0
TLS2_k127_5786248_9 PepSY-associated TM region - - - 0.0000000000000000000000000000000000000000000000000000000000004344 227.0
TLS2_k127_5813485_0 nuclear chromosome segregation - - - 0.0 1065.0
TLS2_k127_5813485_1 Putative glutamine amidotransferase - - - 4.945e-251 799.0
TLS2_k127_5813485_2 Tetratricopeptide repeat - - - 5.141e-234 750.0
TLS2_k127_5813485_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 4.092e-230 717.0
TLS2_k127_5813485_4 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 580.0
TLS2_k127_5813485_5 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 524.0
TLS2_k127_5813485_6 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 370.0
TLS2_k127_5813485_7 Peptidase C14 caspase catalytic subunit p20 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003478 283.0
TLS2_k127_5813485_8 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003839 278.0
TLS2_k127_5817611_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 321.0
TLS2_k127_5817611_1 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000725 260.0
TLS2_k127_5817611_2 Major facilitator superfamily - - - 0.000000000009485 69.0
TLS2_k127_5835289_0 Uncharacterized protein family (UPF0051) K09014 - - 5.008e-256 795.0
TLS2_k127_5835289_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 492.0
TLS2_k127_5835289_2 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 391.0
TLS2_k127_5835289_3 iron-sulfur cluster assembly K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 347.0
TLS2_k127_5835289_4 Belongs to the UPF0403 family - - - 0.0000000000000000000000000000000000000000000002628 171.0
TLS2_k127_5835289_5 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000000000000008149 168.0
TLS2_k127_5835289_6 HTH domain - - - 0.0000000000000000000000000000000000006837 147.0
TLS2_k127_5835289_7 peptide deformylase activity K01462 - 3.5.1.88 0.0000000000000000000000000000000001485 138.0
TLS2_k127_5880425_0 Acetyl xylan esterase (AXE1) - - - 1.837e-245 768.0
TLS2_k127_5890383_0 ASPIC UnbV domain protein - - - 7.068e-249 782.0
TLS2_k127_5931731_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1024.0
TLS2_k127_5931731_1 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 437.0
TLS2_k127_5931731_2 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009577 417.0
TLS2_k127_5931731_3 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001531 268.0
TLS2_k127_5931731_4 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000000000000000000000000000000028 229.0
TLS2_k127_5931731_5 - - - - 0.00000000000000000000000000000000000000000000000007312 192.0
TLS2_k127_5931731_6 pilus organization K07004 - - 0.00000000000000000000000000000000000000000000004881 181.0
TLS2_k127_5931731_7 Sugar-specific transcriptional regulator TrmB - - - 0.000000000000004438 83.0
TLS2_k127_5931731_8 PFAM TonB-dependent receptor plug K02014,K16089 - - 0.000004342 55.0
TLS2_k127_5941198_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.0000000009855 60.0
TLS2_k127_59589_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1216.0
TLS2_k127_59589_1 Protein kinase domain K12132 - 2.7.11.1 5.287e-257 827.0
TLS2_k127_59589_10 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004274 267.0
TLS2_k127_59589_11 metallopeptidase activity K01186,K05994 - 3.2.1.18,3.4.11.10 0.00000000000000000000000000000000000000000000000000000000000002873 234.0
TLS2_k127_59589_12 Domain of unknown function (DUF305) - - - 0.000000000000000000000000000000000000000000000001127 185.0
TLS2_k127_59589_13 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02004 - - 0.000000000000000000000000000000000000000000000007041 188.0
TLS2_k127_59589_14 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K05685 - - 0.0000000000000000000000000000000000000000000149 178.0
TLS2_k127_59589_15 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000000003382 166.0
TLS2_k127_59589_17 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000004519 143.0
TLS2_k127_59589_18 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000002873 141.0
TLS2_k127_59589_19 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000718 136.0
TLS2_k127_59589_2 repeat protein - - - 6.004e-234 740.0
TLS2_k127_59589_20 NHL repeat - - - 0.000000000000000002641 98.0
TLS2_k127_59589_21 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000007439 73.0
TLS2_k127_59589_22 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.000000000007406 69.0
TLS2_k127_59589_25 Diguanylate cyclase - - - 0.0000225 54.0
TLS2_k127_59589_3 domain, Protein - - - 8.507e-226 721.0
TLS2_k127_59589_4 Peptidase M14 - - - 8.375e-210 668.0
TLS2_k127_59589_5 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 591.0
TLS2_k127_59589_6 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 476.0
TLS2_k127_59589_7 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 454.0
TLS2_k127_59589_8 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 412.0
TLS2_k127_59589_9 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 338.0
TLS2_k127_6016307_0 FeoA - - - 2.298e-286 899.0
TLS2_k127_6016307_1 TonB-dependent receptor K16089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 462.0
TLS2_k127_6016307_10 DinB family - - - 0.000000000000000000000000000000001162 137.0
TLS2_k127_6016307_11 Alpha/beta hydrolase of unknown function (DUF1100) K06889 - - 0.000000000000000000000000000000006825 145.0
TLS2_k127_6016307_12 alkyl hydroperoxide reductase - - - 0.0000000000000000000000000000001804 131.0
TLS2_k127_6016307_13 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000006916 125.0
TLS2_k127_6016307_14 Penicillinase repressor - - - 0.000000000000000000000000008176 116.0
TLS2_k127_6016307_15 AraC family - - - 0.0000000000000000000103 96.0
TLS2_k127_6016307_16 AraC-like ligand binding domain - - - 0.00000000000000001413 88.0
TLS2_k127_6016307_17 Platelet-activating factor acetylhydrolase, plasma intracellular isoform II - - - 0.0000000001724 73.0
TLS2_k127_6016307_18 Belongs to the 'phage' integrase family - - - 0.000000003503 60.0
TLS2_k127_6016307_19 Phage integrase, N-terminal SAM-like domain - - - 0.0000006047 52.0
TLS2_k127_6016307_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 434.0
TLS2_k127_6016307_20 Transcriptional regulator K07979 - - 0.000002609 59.0
TLS2_k127_6016307_21 - - - - 0.000008238 58.0
TLS2_k127_6016307_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 391.0
TLS2_k127_6016307_4 iron ion homeostasis K03322,K03709,K04758 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005725 261.0
TLS2_k127_6016307_5 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.00000000000000000000000000000000000000000000000000000000000000000003853 241.0
TLS2_k127_6016307_6 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000001592 191.0
TLS2_k127_6016307_7 Trypsin-like serine protease - - - 0.0000000000000000000000000000000000003382 158.0
TLS2_k127_6016307_8 BlaR1 peptidase M56 - - - 0.000000000000000000000000000000000007412 150.0
TLS2_k127_6016307_9 BAAT / Acyl-CoA thioester hydrolase C terminal K06889 - - 0.00000000000000000000000000000000001173 149.0
TLS2_k127_6071111_0 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.00000000000000000000000000004218 120.0
TLS2_k127_6071111_2 Carboxypeptidase regulatory-like domain - - - 0.0000002047 62.0
TLS2_k127_6071111_3 Carboxypeptidase regulatory-like domain - - - 0.00004627 55.0
TLS2_k127_6071111_4 TonB-dependent receptor - - - 0.0004408 52.0
TLS2_k127_6071111_5 TonB-dependent receptor - - - 0.0006003 51.0
TLS2_k127_608625_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 2.051e-250 786.0
TLS2_k127_608625_1 Peptidase family M28 - - - 9.651e-216 687.0
TLS2_k127_608625_10 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000004001 134.0
TLS2_k127_608625_12 Prokaryotic Cytochrome C oxidase subunit IV K02277,K02300 - 1.9.3.1 0.0000001309 57.0
TLS2_k127_608625_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009336 324.0
TLS2_k127_608625_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 297.0
TLS2_k127_608625_4 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005084 278.0
TLS2_k127_608625_5 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000261 212.0
TLS2_k127_608625_6 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000008153 158.0
TLS2_k127_608625_7 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - 0.0000000000000000000000000000000000000002483 152.0
TLS2_k127_608625_8 Transcription elongation factor, N-terminal K03624 - - 0.0000000000000000000000000000000000000005535 158.0
TLS2_k127_608625_9 Protein of unknown function (DUF423) - - - 0.000000000000000000000000000000000003378 143.0
TLS2_k127_6184656_0 Zinc carboxypeptidase - - - 0.0 1287.0
TLS2_k127_6184656_1 Prolyl oligopeptidase family - - - 1.965e-306 966.0
TLS2_k127_6184656_10 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 593.0
TLS2_k127_6184656_11 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 575.0
TLS2_k127_6184656_12 Putative modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 565.0
TLS2_k127_6184656_13 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 566.0
TLS2_k127_6184656_14 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006617 591.0
TLS2_k127_6184656_15 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 552.0
TLS2_k127_6184656_16 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 560.0
TLS2_k127_6184656_17 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 545.0
TLS2_k127_6184656_18 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 547.0
TLS2_k127_6184656_19 Rhodanese Homology Domain K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 528.0
TLS2_k127_6184656_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 7.99e-301 958.0
TLS2_k127_6184656_20 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 481.0
TLS2_k127_6184656_21 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 506.0
TLS2_k127_6184656_22 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 498.0
TLS2_k127_6184656_23 COG2270 Permeases of the major facilitator superfamily K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 446.0
TLS2_k127_6184656_24 PFAM NAD-dependent epimerase dehydratase K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 431.0
TLS2_k127_6184656_25 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 415.0
TLS2_k127_6184656_26 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000871 417.0
TLS2_k127_6184656_27 Zn_pept - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 406.0
TLS2_k127_6184656_28 COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 387.0
TLS2_k127_6184656_29 carbamoyl transferase, NodU family K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008256 405.0
TLS2_k127_6184656_3 metallocarboxypeptidase activity K14054 - - 4.975e-273 866.0
TLS2_k127_6184656_30 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 380.0
TLS2_k127_6184656_31 ATPases associated with a variety of cellular activities K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008335 378.0
TLS2_k127_6184656_32 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 338.0
TLS2_k127_6184656_33 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00499,K16319 - 1.14.12.1,1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 329.0
TLS2_k127_6184656_34 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 327.0
TLS2_k127_6184656_35 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008064 319.0
TLS2_k127_6184656_36 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 321.0
TLS2_k127_6184656_37 Belongs to the bacterial solute-binding protein 9 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 321.0
TLS2_k127_6184656_38 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 294.0
TLS2_k127_6184656_39 Domain of unknown function (DUF3943) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 298.0
TLS2_k127_6184656_4 COG0744 Membrane carboxypeptidase (penicillin-binding protein) - - - 1.46e-255 821.0
TLS2_k127_6184656_40 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001065 289.0
TLS2_k127_6184656_41 Glycosyl transferase K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000004113 272.0
TLS2_k127_6184656_42 metal-dependent phosphohydrolase, HD sub domain K03698 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001986 258.0
TLS2_k127_6184656_43 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000012 246.0
TLS2_k127_6184656_44 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000002073 227.0
TLS2_k127_6184656_45 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000001965 221.0
TLS2_k127_6184656_46 Metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000288 229.0
TLS2_k127_6184656_47 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K00982,K03564 - 1.11.1.15,2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000007845 213.0
TLS2_k127_6184656_48 Predicted membrane protein (DUF2157) - - - 0.00000000000000000000000000000000000000000000000000000000000816 220.0
TLS2_k127_6184656_49 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000001335 219.0
TLS2_k127_6184656_5 Putative modulator of DNA gyrase K03568 - - 1.183e-235 743.0
TLS2_k127_6184656_50 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000002087 219.0
TLS2_k127_6184656_51 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000007271 217.0
TLS2_k127_6184656_52 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000002267 204.0
TLS2_k127_6184656_53 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000001924 203.0
TLS2_k127_6184656_54 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000001014 198.0
TLS2_k127_6184656_55 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000002678 188.0
TLS2_k127_6184656_56 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000003094 182.0
TLS2_k127_6184656_57 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000002006 187.0
TLS2_k127_6184656_58 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000005661 186.0
TLS2_k127_6184656_59 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000001182 183.0
TLS2_k127_6184656_6 Peptidase U62 modulator of DNA gyrase K03568 - - 4.327e-235 739.0
TLS2_k127_6184656_60 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000359 186.0
TLS2_k127_6184656_61 - - - - 0.00000000000000000000000000000000000000000004447 170.0
TLS2_k127_6184656_62 curli production assembly transport component CsgG K04087 - - 0.0000000000000000000000000000000000000000002438 175.0
TLS2_k127_6184656_63 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000005939 164.0
TLS2_k127_6184656_64 - - - - 0.000000000000000000000000000000000000001434 158.0
TLS2_k127_6184656_65 - - - - 0.000000000000000000000000000000000000003792 161.0
TLS2_k127_6184656_66 epimerase K00486 - 1.14.13.9 0.00000000000000000000000000000000000001011 156.0
TLS2_k127_6184656_67 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000002626 156.0
TLS2_k127_6184656_68 Ankyrin repeat - - - 0.000000000000000000000000000000000007651 148.0
TLS2_k127_6184656_69 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000005128 139.0
TLS2_k127_6184656_7 protein kinase activity - - - 7.604e-211 684.0
TLS2_k127_6184656_70 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000007924 141.0
TLS2_k127_6184656_71 Glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000002226 135.0
TLS2_k127_6184656_72 Cold shock protein K03704 - - 0.00000000000000000000000000001265 119.0
TLS2_k127_6184656_73 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K10778 - 2.1.1.63 0.0000000000000000000000000007444 119.0
TLS2_k127_6184656_74 membrane organization - - - 0.00000000000000000000000001721 125.0
TLS2_k127_6184656_75 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000004192 121.0
TLS2_k127_6184656_76 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000001793 112.0
TLS2_k127_6184656_77 - - - - 0.000000000000000000000009803 109.0
TLS2_k127_6184656_78 Transposase IS200 like - - - 0.00000000000000000000001321 113.0
TLS2_k127_6184656_79 chemotaxis protein K03406 - - 0.00000000000000000000004899 115.0
TLS2_k127_6184656_8 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 5.868e-202 644.0
TLS2_k127_6184656_80 - - - - 0.00000000000000000000004943 110.0
TLS2_k127_6184656_81 - - - - 0.0000000000000002453 83.0
TLS2_k127_6184656_82 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000000001453 83.0
TLS2_k127_6184656_83 BAAT / Acyl-CoA thioester hydrolase C terminal K06889 - - 0.000000000003118 79.0
TLS2_k127_6184656_84 Aerotolerance regulator N-terminal - - - 0.0000000001135 74.0
TLS2_k127_6184656_85 - - - - 0.000000001149 70.0
TLS2_k127_6184656_87 Ornithine decarboxylase inhibitor-putative sigma54 transciptional regulator K02584 - - 0.00000001881 57.0
TLS2_k127_6184656_88 Domain of unknown function (DUF4824) - - - 0.00000009581 62.0
TLS2_k127_6184656_89 - - - - 0.0000001967 63.0
TLS2_k127_6184656_9 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 610.0
TLS2_k127_6184656_90 - - - - 0.0000003527 63.0
TLS2_k127_6184656_91 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.000001933 52.0
TLS2_k127_6184656_92 Membrane - - - 0.00001861 57.0
TLS2_k127_6184656_93 TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - 0.0001371 52.0
TLS2_k127_6184656_94 competence protein - - - 0.0003634 51.0
TLS2_k127_6231675_0 Lipid A 3-O-deacylase (PagL) - - - 0.00005286 53.0
TLS2_k127_6231675_1 - - - - 0.0001779 53.0
TLS2_k127_6261065_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 1.267e-290 917.0
TLS2_k127_6261065_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.716e-272 854.0
TLS2_k127_6261065_10 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 323.0
TLS2_k127_6261065_11 Histidine kinase K02668,K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 336.0
TLS2_k127_6261065_12 phosphorelay signal transduction system K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003038 274.0
TLS2_k127_6261065_13 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003237 268.0
TLS2_k127_6261065_14 Belongs to the AB hydrolase superfamily. MetX family K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000001353 243.0
TLS2_k127_6261065_15 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000001321 214.0
TLS2_k127_6261065_16 - - - - 0.000000000000000000000000000000000000000000000000000000003501 209.0
TLS2_k127_6261065_17 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000001682 184.0
TLS2_k127_6261065_18 ACT domain K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000006222 186.0
TLS2_k127_6261065_19 HAD-hyrolase-like K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000001121 159.0
TLS2_k127_6261065_2 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 571.0
TLS2_k127_6261065_20 PFAM BioY protein K03523 - - 0.000000000000000000000000000275 122.0
TLS2_k127_6261065_21 CsbD-like - - - 0.000000000000000000001319 98.0
TLS2_k127_6261065_22 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000001042 92.0
TLS2_k127_6261065_23 response regulator K07782 - - 0.00000000006253 67.0
TLS2_k127_6261065_24 Protein of unknown function (DUF1328) - - - 0.0000000001942 63.0
TLS2_k127_6261065_25 response to copper ion K07156 - - 0.000000007851 68.0
TLS2_k127_6261065_26 Histidine kinase - - - 0.0000001208 64.0
TLS2_k127_6261065_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006402 524.0
TLS2_k127_6261065_4 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 527.0
TLS2_k127_6261065_5 TrkA-C domain K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 520.0
TLS2_k127_6261065_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 498.0
TLS2_k127_6261065_7 cystathionine K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 486.0
TLS2_k127_6261065_8 PFAM short chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 398.0
TLS2_k127_6261065_9 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 390.0
TLS2_k127_6299513_0 Fic/DOC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 405.0
TLS2_k127_6299513_1 Amidohydrolase - - - 0.000000000000000000000001887 116.0
TLS2_k127_6344444_0 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 301.0
TLS2_k127_6344444_1 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000001032 248.0
TLS2_k127_6344444_2 transport - - - 0.0000000000000000000000000000004858 139.0
TLS2_k127_6344444_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 0.0000000000000000000000000000004895 131.0
TLS2_k127_6344444_4 Carboxypeptidase regulatory-like domain K02014 - - 0.0000000000001772 76.0
TLS2_k127_6344444_5 TonB-dependent Receptor Plug Domain - - - 0.000002007 59.0
TLS2_k127_6350269_0 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 376.0
TLS2_k127_6350269_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 337.0
TLS2_k127_6403028_0 belongs to the thioredoxin family K20543 - - 2.987e-297 932.0
TLS2_k127_6403028_1 Dehydrogenase K00117 - 1.1.5.2 4.879e-194 626.0
TLS2_k127_6403028_10 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 363.0
TLS2_k127_6403028_11 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 355.0
TLS2_k127_6403028_12 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 359.0
TLS2_k127_6403028_13 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 344.0
TLS2_k127_6403028_14 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 362.0
TLS2_k127_6403028_15 phosphorelay signal transduction system K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001331 306.0
TLS2_k127_6403028_16 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000006326 271.0
TLS2_k127_6403028_17 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001083 283.0
TLS2_k127_6403028_18 cytochrome C peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000038 254.0
TLS2_k127_6403028_19 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008106 225.0
TLS2_k127_6403028_2 Alpha-L-fucosidase K01206 - 3.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 616.0
TLS2_k127_6403028_20 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000009834 218.0
TLS2_k127_6403028_21 PFAM Tripartite ATP-independent periplasmic transporter DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000886 213.0
TLS2_k127_6403028_22 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000000000000000000000000000000001781 189.0
TLS2_k127_6403028_23 DNA-templated transcription, initiation K02405 - - 0.0000000000000000000000000000000000000000000000001885 183.0
TLS2_k127_6403028_24 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000005019 174.0
TLS2_k127_6403028_25 SnoaL-like domain - - - 0.00000000000000000000000000000000000000001505 158.0
TLS2_k127_6403028_26 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000008484 159.0
TLS2_k127_6403028_27 - - - - 0.00000000000000000000000000000000000004387 149.0
TLS2_k127_6403028_28 WHG domain - - - 0.0000000000000000000000000000000002567 139.0
TLS2_k127_6403028_29 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000003198 130.0
TLS2_k127_6403028_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008208 554.0
TLS2_k127_6403028_30 HupE / UreJ protein - - - 0.00000000000000000000246 99.0
TLS2_k127_6403028_31 Domain of unknown function (DUF4342) - - - 0.0000000000000000001117 92.0
TLS2_k127_6403028_33 Involved in initiation control of chromosome replication K07484 - - 0.00000000000000003797 88.0
TLS2_k127_6403028_35 TonB dependent receptor K02014,K16087 - - 0.00000008327 64.0
TLS2_k127_6403028_37 Carboxypeptidase regulatory-like domain - - - 0.0000271 55.0
TLS2_k127_6403028_38 Carboxypeptidase regulatory-like domain - - - 0.0000562 55.0
TLS2_k127_6403028_39 PFAM PEGA domain - - - 0.0006416 51.0
TLS2_k127_6403028_4 ASPIC UnbV domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 496.0
TLS2_k127_6403028_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007338 484.0
TLS2_k127_6403028_6 HpcH/HpaI aldolase/citrate lyase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000725 455.0
TLS2_k127_6403028_7 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 453.0
TLS2_k127_6403028_8 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 404.0
TLS2_k127_6403028_9 Band 7 protein K07192 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 395.0
TLS2_k127_6430984_0 heme-copper terminal oxidase activity K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 618.0
TLS2_k127_6430984_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 445.0
TLS2_k127_6430984_10 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000000000006491 160.0
TLS2_k127_6430984_11 - - - - 0.00000000000000000000000004279 112.0
TLS2_k127_6430984_13 - - - - 0.00000000000000000001784 95.0
TLS2_k127_6430984_14 SCO1/SenC K07152 - - 0.00000000000006534 82.0
TLS2_k127_6430984_15 - - - - 0.000000209 54.0
TLS2_k127_6430984_16 Membrane - - - 0.0000009634 57.0
TLS2_k127_6430984_17 Putative metallopeptidase - - - 0.00001659 55.0
TLS2_k127_6430984_18 - - - - 0.00009318 54.0
TLS2_k127_6430984_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 407.0
TLS2_k127_6430984_3 D-aminopeptidase K16203 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 385.0
TLS2_k127_6430984_4 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 359.0
TLS2_k127_6430984_5 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 318.0
TLS2_k127_6430984_6 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008697 304.0
TLS2_k127_6430984_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005429 291.0
TLS2_k127_6430984_8 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002258 261.0
TLS2_k127_6430984_9 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000002031 198.0
TLS2_k127_6462889_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 302.0
TLS2_k127_6462889_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000003224 182.0
TLS2_k127_6462889_2 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000005418 184.0
TLS2_k127_6462889_3 - - - - 0.000000000001279 74.0
TLS2_k127_6562433_0 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 546.0
TLS2_k127_6562433_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 426.0
TLS2_k127_6562433_10 - - - - 0.000000000000000000000000000002489 130.0
TLS2_k127_6562433_11 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000001257 71.0
TLS2_k127_6562433_12 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000666 66.0
TLS2_k127_6562433_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 386.0
TLS2_k127_6562433_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 379.0
TLS2_k127_6562433_4 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007791 269.0
TLS2_k127_6562433_5 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000002014 223.0
TLS2_k127_6562433_6 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000003381 206.0
TLS2_k127_6562433_7 transcriptional activator domain - - - 0.0000000000000000000000000000000128 148.0
TLS2_k127_6562433_8 Diguanylate cyclase - - - 0.00000000000000000000000000000007692 142.0
TLS2_k127_6562433_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000009793 134.0
TLS2_k127_6574514_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 9.856e-284 878.0
TLS2_k127_6574514_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 4.082e-282 894.0
TLS2_k127_6574514_10 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 465.0
TLS2_k127_6574514_11 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 467.0
TLS2_k127_6574514_12 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 431.0
TLS2_k127_6574514_13 Glycosyl transferase 4-like K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 428.0
TLS2_k127_6574514_14 Nucleotidyl transferase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 324.0
TLS2_k127_6574514_15 Protein of unknown function (DUF1194) K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 318.0
TLS2_k127_6574514_16 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 312.0
TLS2_k127_6574514_17 Zinc dependent phospholipase C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 316.0
TLS2_k127_6574514_18 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K04040,K20616 - 2.5.1.133,2.5.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000007321 262.0
TLS2_k127_6574514_19 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005328 260.0
TLS2_k127_6574514_2 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.73e-218 703.0
TLS2_k127_6574514_20 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001346 257.0
TLS2_k127_6574514_21 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000002624 238.0
TLS2_k127_6574514_22 Sugar nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001056 239.0
TLS2_k127_6574514_23 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000007135 224.0
TLS2_k127_6574514_24 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000001257 211.0
TLS2_k127_6574514_25 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000001706 214.0
TLS2_k127_6574514_26 von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000002274 227.0
TLS2_k127_6574514_27 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000002661 213.0
TLS2_k127_6574514_28 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000001561 217.0
TLS2_k127_6574514_29 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000001288 208.0
TLS2_k127_6574514_3 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 594.0
TLS2_k127_6574514_30 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000001558 193.0
TLS2_k127_6574514_31 Ferric reductase like transmembrane component - - - 0.00000000000000000000000000000000000000000000000007778 182.0
TLS2_k127_6574514_32 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.000000000000000000000000000000000000006917 156.0
TLS2_k127_6574514_33 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000004713 134.0
TLS2_k127_6574514_34 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000000000000000006574 132.0
TLS2_k127_6574514_35 SpoVT / AbrB like domain - - - 0.0000000000000000000000000004866 115.0
TLS2_k127_6574514_36 NlpC p60 family K19224,K21471 - - 0.00000000000000000000000003979 120.0
TLS2_k127_6574514_37 - - - - 0.000000000000000000000001963 110.0
TLS2_k127_6574514_38 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000005215 106.0
TLS2_k127_6574514_39 Zinc finger domain - - - 0.00000000000000000001375 104.0
TLS2_k127_6574514_4 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 585.0
TLS2_k127_6574514_40 PIN domain - - - 0.00000000000000000007956 93.0
TLS2_k127_6574514_41 Oxygen tolerance - - - 0.0000000000000001091 94.0
TLS2_k127_6574514_42 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000001723 84.0
TLS2_k127_6574514_43 PFAM blue (type 1) copper domain protein - - - 0.000000005645 68.0
TLS2_k127_6574514_44 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000005835 61.0
TLS2_k127_6574514_45 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - 0.0000001608 57.0
TLS2_k127_6574514_46 PFAM Roadblock LC7 K07131 - - 0.0000283 51.0
TLS2_k127_6574514_47 Binds directly to 16S ribosomal RNA K02968 - - 0.00007738 50.0
TLS2_k127_6574514_49 PFAM blue (type 1) copper domain protein - - - 0.0001913 53.0
TLS2_k127_6574514_5 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 571.0
TLS2_k127_6574514_6 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 516.0
TLS2_k127_6574514_7 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 515.0
TLS2_k127_6574514_8 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 505.0
TLS2_k127_6574514_9 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 476.0
TLS2_k127_6691659_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007574 330.0
TLS2_k127_6691659_1 - - - - 0.00000000000000000000000000000000000003596 151.0
TLS2_k127_6691659_2 Peptidase family M1 domain - - - 0.000000000000000000000000000005003 138.0
TLS2_k127_6691659_3 - - - - 0.0000000000000000000000000142 115.0
TLS2_k127_6691659_4 thiolester hydrolase activity K06889 - - 0.00000000000000000003739 103.0
TLS2_k127_6691659_6 aminopeptidase N - - - 0.00006537 55.0
TLS2_k127_6692606_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1062.0
TLS2_k127_6692606_1 MaoC like domain K02618 - 1.2.1.91,3.3.2.12 2.731e-317 983.0
TLS2_k127_6692606_10 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 469.0
TLS2_k127_6692606_11 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 428.0
TLS2_k127_6692606_12 PFAM peptidase M18 aminopeptidase I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 426.0
TLS2_k127_6692606_13 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004226 396.0
TLS2_k127_6692606_14 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 374.0
TLS2_k127_6692606_15 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008755 352.0
TLS2_k127_6692606_16 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 354.0
TLS2_k127_6692606_17 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 352.0
TLS2_k127_6692606_18 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 339.0
TLS2_k127_6692606_19 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008682 328.0
TLS2_k127_6692606_2 dehydrogenase, E1 component K11381 - 1.2.4.4 6.658e-308 957.0
TLS2_k127_6692606_20 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 320.0
TLS2_k127_6692606_21 Bacterial transferase hexapeptide (six repeats) K02617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 316.0
TLS2_k127_6692606_22 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003418 289.0
TLS2_k127_6692606_23 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002155 286.0
TLS2_k127_6692606_24 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000618 269.0
TLS2_k127_6692606_25 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000002802 261.0
TLS2_k127_6692606_26 Peptidase family S51 K13282 - 3.4.15.6 0.0000000000000000000000000000000000000000000000000000000000002289 222.0
TLS2_k127_6692606_27 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000006169 228.0
TLS2_k127_6692606_28 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000007511 231.0
TLS2_k127_6692606_29 Flavodoxin-like fold K11748 - - 0.00000000000000000000000000000000000000000000000000000000006306 211.0
TLS2_k127_6692606_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 8.297e-208 664.0
TLS2_k127_6692606_30 phosphinothricin N-acetyltransferase activity K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000000001515 207.0
TLS2_k127_6692606_31 Peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000001895 199.0
TLS2_k127_6692606_32 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000002335 204.0
TLS2_k127_6692606_33 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000001472 183.0
TLS2_k127_6692606_34 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000000000001506 169.0
TLS2_k127_6692606_35 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000000000000008832 166.0
TLS2_k127_6692606_36 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000004114 185.0
TLS2_k127_6692606_37 PFAM Rhomboid family protein - - - 0.00000000000000000000000000000000000002239 158.0
TLS2_k127_6692606_38 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000001491 148.0
TLS2_k127_6692606_39 ECF sigma factor K03088 - - 0.000000000000000000000000000000001199 142.0
TLS2_k127_6692606_4 Amidohydrolase family K06015 - 3.5.1.81 5.844e-206 657.0
TLS2_k127_6692606_40 - - - - 0.00000000000000000000000000000008667 140.0
TLS2_k127_6692606_41 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000001108 137.0
TLS2_k127_6692606_42 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000007933 119.0
TLS2_k127_6692606_43 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000001242 111.0
TLS2_k127_6692606_44 HEAT repeats - - - 0.0000000000000000000000003747 122.0
TLS2_k127_6692606_45 transcriptional regulator - - - 0.0000000000000000000000007944 112.0
TLS2_k127_6692606_46 Bacterial transcriptional activator domain - - - 0.00000000000000000002364 107.0
TLS2_k127_6692606_47 TM2 domain - - - 0.000000000000000000142 96.0
TLS2_k127_6692606_48 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000001862 89.0
TLS2_k127_6692606_5 Thiolase, C-terminal domain K02615 - 2.3.1.174,2.3.1.223 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 578.0
TLS2_k127_6692606_50 PDZ domain - - - 0.0000000000000001078 91.0
TLS2_k127_6692606_51 DinB family - - - 0.00000000003844 70.0
TLS2_k127_6692606_52 Protein of unknown function (DUF3187) - - - 0.000000022 66.0
TLS2_k127_6692606_53 - - - - 0.0000008978 54.0
TLS2_k127_6692606_54 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.000003735 52.0
TLS2_k127_6692606_6 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 554.0
TLS2_k127_6692606_7 DNA polymerase alpha chain like domain K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 539.0
TLS2_k127_6692606_8 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 509.0
TLS2_k127_6692606_9 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 491.0
TLS2_k127_6713539_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 498.0
TLS2_k127_6713539_1 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 429.0
TLS2_k127_6713539_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000003936 249.0
TLS2_k127_6713539_3 OmpA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004543 255.0
TLS2_k127_6713539_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001312 238.0
TLS2_k127_6713539_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000003655 220.0
TLS2_k127_6713539_6 - - - - 0.0000000000000000000002835 105.0
TLS2_k127_6713539_7 - - - - 0.0000000000000001216 89.0
TLS2_k127_6713539_8 glyoxalase III activity - - - 0.0000000000000001275 87.0
TLS2_k127_6725346_0 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006828 548.0
TLS2_k127_6725346_1 DUF1704 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 495.0
TLS2_k127_6725346_10 Phenylacetic acid degradation B K02610 - - 0.000000000000000000000000000000000000000000000003031 176.0
TLS2_k127_6725346_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000001048 145.0
TLS2_k127_6725346_12 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000003845 104.0
TLS2_k127_6725346_13 Carbon-nitrogen hydrolase - - - 0.00000000000001281 81.0
TLS2_k127_6725346_14 - - - - 0.000000006001 68.0
TLS2_k127_6725346_15 Bacterial Ig-like domain 2 - - - 0.000003966 59.0
TLS2_k127_6725346_2 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 432.0
TLS2_k127_6725346_3 class I DNA-(apurinic or apyrimidinic site) endonuclease activity K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005678 378.0
TLS2_k127_6725346_4 COG0454 Histone acetyltransferase HPA2 and related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 370.0
TLS2_k127_6725346_5 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 320.0
TLS2_k127_6725346_6 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 306.0
TLS2_k127_6725346_7 N-formylglutamate amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 298.0
TLS2_k127_6725346_8 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003278 273.0
TLS2_k127_6725346_9 Pfam:DUF59 K02612 - - 0.00000000000000000000000000000000000000000000000001409 184.0
TLS2_k127_6732156_0 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 367.0
TLS2_k127_6732156_1 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006243 271.0
TLS2_k127_6732156_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000002386 225.0
TLS2_k127_6732156_3 Domain of unknown function (DUF4405) - - - 0.0000000000000000000000000003532 124.0
TLS2_k127_6732156_4 molybdopterin cofactor binding - - - 0.0000000000000000000001867 102.0
TLS2_k127_6806839_0 LytB protein K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 472.0
TLS2_k127_6853951_0 aminotransferase class I and II K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 409.0
TLS2_k127_6853951_1 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 384.0
TLS2_k127_6853951_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000333 248.0
TLS2_k127_6902531_0 transposase activity - - - 0.000000000000000000000000000000000000000000000000417 181.0
TLS2_k127_7051450_0 repeat protein - - - 6.337e-223 706.0
TLS2_k127_7051450_1 Na H antiporter K03315 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 583.0
TLS2_k127_7051450_2 2-epimerase K16213 - 5.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009981 402.0
TLS2_k127_7051450_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000299 236.0
TLS2_k127_7051450_4 Participates in the control of copper homeostasis K06201 - - 0.0000000000000000000000000000000000000000001948 175.0
TLS2_k127_7051450_5 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000000000000001592 143.0
TLS2_k127_709323_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0 3128.0
TLS2_k127_709323_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 5.747e-218 713.0
TLS2_k127_709323_10 - - - - 0.000000000000000000000000000000000000000551 160.0
TLS2_k127_709323_11 - - - - 0.0000000000000000000000000000000000002158 146.0
TLS2_k127_709323_12 FAD dependent oxidoreductase K19813 - 1.1.5.9 0.0000000000000000000000000000001156 133.0
TLS2_k127_709323_13 Pfam:DUF3816 K16788 - - 0.0000000000000009837 85.0
TLS2_k127_709323_14 - - - - 0.00000003742 61.0
TLS2_k127_709323_2 PFAM peptidase dimerisation domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 564.0
TLS2_k127_709323_3 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 519.0
TLS2_k127_709323_4 Putative zinc-binding metallo-peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 492.0
TLS2_k127_709323_5 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009068 426.0
TLS2_k127_709323_6 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 407.0
TLS2_k127_709323_7 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009749 338.0
TLS2_k127_709323_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000006454 168.0
TLS2_k127_709323_9 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000003472 177.0
TLS2_k127_7097289_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 396.0
TLS2_k127_7097289_1 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000007548 127.0
TLS2_k127_7097289_2 O-acyltransferase activity - - - 0.000000000000000000000000114 117.0
TLS2_k127_7098737_0 E1-E2 ATPase K17686 - 3.6.3.54 2.187e-300 942.0
TLS2_k127_7098737_1 Prolyl oligopeptidase family - - - 4.071e-292 922.0
TLS2_k127_7098737_10 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000005439 195.0
TLS2_k127_7098737_11 Nodulation protein S (NodS) - - - 0.000000000000000000000000000000000000000000004109 173.0
TLS2_k127_7098737_12 S4 RNA-binding domain K04762 - - 0.00000000000000000000000000000137 128.0
TLS2_k127_7098737_13 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000006245 136.0
TLS2_k127_7098737_14 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000001 137.0
TLS2_k127_7098737_15 - - - - 0.00000000000000000000000000002093 128.0
TLS2_k127_7098737_16 Domain of unknown function (DUF1736) - - - 0.0000000000000000000000001904 123.0
TLS2_k127_7098737_17 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.0000000000000000009147 94.0
TLS2_k127_7098737_18 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000001643 80.0
TLS2_k127_7098737_19 Domain of unknown function (DUF4412) - - - 0.0000000152 66.0
TLS2_k127_7098737_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 2.275e-259 833.0
TLS2_k127_7098737_20 Cupredoxin-like domain - - - 0.0003703 43.0
TLS2_k127_7098737_3 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 610.0
TLS2_k127_7098737_4 PAS domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000959 346.0
TLS2_k127_7098737_5 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 297.0
TLS2_k127_7098737_6 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.000000000000000000000000000000000000000000000000000000000000000006091 236.0
TLS2_k127_7098737_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000006231 244.0
TLS2_k127_7098737_8 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000002749 224.0
TLS2_k127_7098737_9 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000005153 203.0
TLS2_k127_7123542_0 TonB-dependent Receptor Plug Domain K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 628.0
TLS2_k127_7123542_1 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 389.0
TLS2_k127_7123542_2 3-hydroxyacyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000003752 153.0
TLS2_k127_7123542_3 TonB-dependent receptor K16089 - - 0.00000000000000000009109 93.0
TLS2_k127_7123542_4 Putative phosphatase (DUF442) - - - 0.000000000000006076 80.0
TLS2_k127_7123542_5 Outer membrane protein beta-barrel domain - - - 0.0000000001232 73.0
TLS2_k127_7123542_6 cell adhesion involved in biofilm formation - - - 0.0000000005738 72.0
TLS2_k127_7123542_7 SnoaL-like domain - - - 0.00000001467 61.0
TLS2_k127_7123542_8 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000299 48.0
TLS2_k127_7219337_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000001022 123.0
TLS2_k127_7219337_1 Protein of unknown function DUF116 - - - 0.00000000000000000000000000000193 132.0
TLS2_k127_7219337_2 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000001667 121.0
TLS2_k127_7219337_3 glyoxalase III activity - - - 0.0000001283 63.0
TLS2_k127_7219337_4 Gram-negative bacterial TonB protein C-terminal - - - 0.00001003 50.0
TLS2_k127_7238727_0 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 336.0
TLS2_k127_7238727_1 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005189 258.0
TLS2_k127_7238727_2 PFAM Peptidase family M23 - - - 0.0000000000000000000000000168 119.0
TLS2_k127_7262863_0 - - - - 2.53e-311 962.0
TLS2_k127_7262863_1 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 440.0
TLS2_k127_7262863_2 serine-type peptidase activity - - - 0.0000000000000000000000000000000000000000002653 179.0
TLS2_k127_7262863_3 BAAT / Acyl-CoA thioester hydrolase C terminal K06889 - - 0.000000000000000000000000000000000000000007861 171.0
TLS2_k127_7262863_4 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000003017 120.0
TLS2_k127_7262863_5 Helix-turn-helix domain - - - 0.0000647 52.0
TLS2_k127_7262863_6 - - - - 0.0003659 52.0
TLS2_k127_7389795_0 Protein of unknown function DUF86 - - - 0.00000000000000000000000534 109.0
TLS2_k127_7389795_1 PFAM DNA polymerase beta domain protein region K07075 - - 0.00000000000000000002733 94.0
TLS2_k127_7389795_2 carboxylic ester hydrolase activity - - - 0.00000000000001968 78.0
TLS2_k127_7389795_3 CAAX protease self-immunity - - - 0.0006682 47.0
TLS2_k127_7471626_0 Phage portal protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000085 561.0
TLS2_k127_7471626_1 COGs COG4626 Phage terminase-like protein large subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 552.0
TLS2_k127_7471626_10 Prophage tail length tape measure protein - - - 0.000000000000000000000000000000000000000000000000000000927 216.0
TLS2_k127_7471626_12 - - - - 0.0000000000000000000000000000000000000000000004152 176.0
TLS2_k127_7471626_13 HNH endonuclease K07451 - - 0.00000000000000000000000000000000000000000002709 163.0
TLS2_k127_7471626_14 - - - - 0.0000000000000000000000000000000000000000004899 163.0
TLS2_k127_7471626_15 Domain of unknown function (DUF1833) - - - 0.0000000000000000000000000000000000001424 147.0
TLS2_k127_7471626_16 Phage gp6-like head-tail connector protein - - - 0.0000000000000000000000000000000000008033 145.0
TLS2_k127_7471626_17 YqaJ-like viral recombinase domain - - - 0.0000000000000000000000000000000004009 142.0
TLS2_k127_7471626_18 N-Acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000276 133.0
TLS2_k127_7471626_19 NlpC/P60 family - - - 0.00000000000000000000000001457 118.0
TLS2_k127_7471626_2 Phage-related protein, tail - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004325 474.0
TLS2_k127_7471626_20 endonuclease activity K07451 - - 0.0000000000000000000000005619 113.0
TLS2_k127_7471626_21 Protein of unknown function (DUF1376) - - - 0.000000000000000000000000597 110.0
TLS2_k127_7471626_22 Protein conserved in bacteria K07316 - 2.1.1.72 0.0000000000000000000000137 104.0
TLS2_k127_7471626_23 Phage-related protein, tail - - - 0.0000000000000000000001795 102.0
TLS2_k127_7471626_24 - - - - 0.0000000000000000000005946 101.0
TLS2_k127_7471626_26 Phage head-tail adaptor - - - 0.00000000000000000006836 92.0
TLS2_k127_7471626_27 - - - - 0.0000000000003939 72.0
TLS2_k127_7471626_28 Bacteriophage HK97-gp10, putative tail-component - - - 0.000000000007391 72.0
TLS2_k127_7471626_29 Protein of unknown function (DUF3168) - - - 0.00000000005378 67.0
TLS2_k127_7471626_3 TIGRFAM phage major capsid protein, HK97 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 431.0
TLS2_k127_7471626_30 Phage terminase, small subunit - - - 0.00000000008311 69.0
TLS2_k127_7471626_31 - - - - 0.0000000001271 64.0
TLS2_k127_7471626_32 - - - - 0.0000000006086 64.0
TLS2_k127_7471626_36 COG1403 Restriction endonuclease - - - 0.000001345 58.0
TLS2_k127_7471626_37 - - - - 0.000003205 56.0
TLS2_k127_7471626_38 - - - - 0.000005617 53.0
TLS2_k127_7471626_39 Polysaccharide lyase - - - 0.000007819 59.0
TLS2_k127_7471626_4 DEAD-like helicases superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 344.0
TLS2_k127_7471626_5 Serine dehydrogenase proteinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002568 280.0
TLS2_k127_7471626_6 P4 alpha zinc-binding domain protein K06919 - - 0.00000000000000000000000000000000000000000000000000000000000000000001392 244.0
TLS2_k127_7471626_7 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000008014 241.0
TLS2_k127_7471626_8 - - - - 0.000000000000000000000000000000000000000000000000000000001116 207.0
TLS2_k127_7471626_9 - - - - 0.0000000000000000000000000000000000000000000000000000000176 206.0
TLS2_k127_928165_0 Protein kinase domain K12132 - 2.7.11.1 1.244e-285 902.0
TLS2_k127_928165_1 PFAM peptidase S10 serine carboxypeptidase - - - 1.087e-226 711.0
TLS2_k127_928165_2 Beta-eliminating lyase K01668 - 4.1.99.2 1.039e-207 657.0
TLS2_k127_928165_3 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 557.0
TLS2_k127_928165_4 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 491.0
TLS2_k127_928165_5 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000003535 267.0
TLS2_k127_928165_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003698 271.0
TLS2_k127_928165_7 - - - - 0.0000000000007173 75.0
TLS2_k127_94277_0 PQQ enzyme repeat K00117 - 1.1.5.2 2.727e-218 698.0
TLS2_k127_94277_1 Kelch repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009587 494.0
TLS2_k127_94277_10 Uncharacterised nucleotidyltransferase - - - 0.000006015 58.0
TLS2_k127_94277_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 383.0
TLS2_k127_94277_3 teichoic acid transport K01990,K09689,K09691 - 3.6.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 378.0
TLS2_k127_94277_4 short-chain dehydrogenase reductase SDR K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009243 330.0
TLS2_k127_94277_5 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004096 286.0
TLS2_k127_94277_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001879 273.0
TLS2_k127_94277_7 macromolecule localization K01992,K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007484 263.0
TLS2_k127_94277_8 CarboxypepD_reg-like domain - - - 0.00000000000000000000000000000587 139.0
TLS2_k127_94277_9 anaphase-promoting complex binding K06922 - - 0.00000000000000000000000000007482 135.0
TLS2_k127_953846_0 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005984 501.0
TLS2_k127_953846_1 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 451.0
TLS2_k127_953846_2 Polyprenyl synthetase K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 358.0
TLS2_k127_953846_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000006583 219.0
TLS2_k127_953846_4 Domain of unknown function (DUF4321) - - - 0.000000000000000000005085 96.0
TLS2_k127_953846_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000004358 72.0
TLS2_k127_953846_6 cellulase activity K06882 - - 0.000000000001179 79.0
TLS2_k127_957074_0 Belongs to the UPF0061 (SELO) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 558.0
TLS2_k127_957074_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 531.0
TLS2_k127_957074_10 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 307.0
TLS2_k127_957074_11 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000007449 264.0
TLS2_k127_957074_12 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000001393 243.0
TLS2_k127_957074_13 gluconolactonase activity K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000003428 222.0
TLS2_k127_957074_14 PFAM Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000005212 218.0
TLS2_k127_957074_15 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000001633 198.0
TLS2_k127_957074_17 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000006237 190.0
TLS2_k127_957074_18 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000007682 164.0
TLS2_k127_957074_19 Sel1-like repeats. K07126 - - 0.00000000000000000000000000000000001135 147.0
TLS2_k127_957074_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 462.0
TLS2_k127_957074_20 Thioredoxin - - - 0.00000000000000000000000000000001361 133.0
TLS2_k127_957074_21 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281 - 3.5.1.19 0.00000000000000000000000000009614 124.0
TLS2_k127_957074_22 Cache domain - - - 0.000000000000000000000000001224 130.0
TLS2_k127_957074_23 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000003317 126.0
TLS2_k127_957074_24 - - - - 0.000000000000000002326 92.0
TLS2_k127_957074_25 Transcriptional regulator K22106 - - 0.0000000000001561 81.0
TLS2_k127_957074_26 ABC-2 family transporter protein K01992 - - 0.000000000004183 77.0
TLS2_k127_957074_27 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000009889 66.0
TLS2_k127_957074_29 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0000015 51.0
TLS2_k127_957074_3 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 451.0
TLS2_k127_957074_31 von Willebrand factor (vWF) type A domain - - - 0.0001622 52.0
TLS2_k127_957074_32 - - - - 0.0008092 49.0
TLS2_k127_957074_4 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 418.0
TLS2_k127_957074_5 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 432.0
TLS2_k127_957074_6 Asparaginase K01444 - 3.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000651 372.0
TLS2_k127_957074_7 abc transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 331.0
TLS2_k127_957074_8 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 335.0
TLS2_k127_957074_9 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 304.0
TLS2_k127_976040_0 Serine threonine protein kinase K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007542 517.0
TLS2_k127_976040_1 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 374.0
TLS2_k127_976040_2 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 307.0
TLS2_k127_976040_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000002595 215.0
TLS2_k127_976040_4 glyoxalase III activity K02005 - - 0.000000000000000000000000000000000000000000000000000002688 195.0
TLS2_k127_976040_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000005029 178.0
TLS2_k127_976040_6 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000000001079 152.0
TLS2_k127_976040_7 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000005766 105.0
TLS2_k127_990328_0 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 437.0
TLS2_k127_990328_1 E1-E2 ATPase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 407.0
TLS2_k127_990328_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 339.0
TLS2_k127_990328_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001037 269.0
TLS2_k127_990328_4 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.00000000000002355 78.0
TLS2_k127_995116_0 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 3.248e-229 745.0
TLS2_k127_995116_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 4.252e-228 719.0
TLS2_k127_995116_10 SMP-30 Gluconolaconase LRE domain protein K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 354.0
TLS2_k127_995116_11 PFAM sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 327.0
TLS2_k127_995116_12 Coenzyme A transferase K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 313.0
TLS2_k127_995116_13 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000432 314.0
TLS2_k127_995116_14 Coenzyme A transferase K01029 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 290.0
TLS2_k127_995116_15 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002266 281.0
TLS2_k127_995116_16 2-epimerase K16213 - 5.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000002219 273.0
TLS2_k127_995116_17 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003116 262.0
TLS2_k127_995116_18 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000009943 244.0
TLS2_k127_995116_19 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000001212 246.0
TLS2_k127_995116_2 Bacterial regulatory protein, Fis family - - - 5.719e-204 647.0
TLS2_k127_995116_20 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000001279 224.0
TLS2_k127_995116_21 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000002298 195.0
TLS2_k127_995116_22 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.0000000000000000000000000000000000000000000000000264 193.0
TLS2_k127_995116_23 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000295 194.0
TLS2_k127_995116_24 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000001052 185.0
TLS2_k127_995116_25 NUDIX domain - - - 0.0000000000000000000000000000000000000000004727 167.0
TLS2_k127_995116_26 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000001058 165.0
TLS2_k127_995116_27 SdpI/YhfL protein family - - - 0.0000000000000000000000000000000000000001092 159.0
TLS2_k127_995116_28 involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000002249 159.0
TLS2_k127_995116_29 - - - - 0.00000000000000000000000000000000000001249 165.0
TLS2_k127_995116_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K02887,K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 600.0
TLS2_k127_995116_30 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000000000000005376 154.0
TLS2_k127_995116_31 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000006746 154.0
TLS2_k127_995116_32 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000002119 138.0
TLS2_k127_995116_33 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.0000000000000000000000000000000002201 148.0
TLS2_k127_995116_34 Helix-turn-helix domain - - - 0.000000000000000000000000000000003224 138.0
TLS2_k127_995116_35 Protein conserved in bacteria - - - 0.0000000000000000000000000002257 131.0
TLS2_k127_995116_36 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788,K14153 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000565 121.0
TLS2_k127_995116_37 Membrane - - - 0.000000000000000000000000001074 129.0
TLS2_k127_995116_38 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.000000000000000000000004487 112.0
TLS2_k127_995116_39 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000000000008365 106.0
TLS2_k127_995116_4 Beta-eliminating lyase K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005045 558.0
TLS2_k127_995116_40 Uncharacterised nucleotidyltransferase - - - 0.000000000000002715 89.0
TLS2_k127_995116_41 - - - - 0.00000003611 59.0
TLS2_k127_995116_5 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 449.0
TLS2_k127_995116_6 Zinc-binding dehydrogenase K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 415.0
TLS2_k127_995116_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 411.0
TLS2_k127_995116_8 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 410.0
TLS2_k127_995116_9 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 401.0