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Overview

ID MAG04018
Name TLS2_bin.6
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Longimicrobiales
Family RSA9
Genus SH-MAG3
Species
Assembly information
Completeness (%) 92.87
Contamination (%) 2.21
GC content (%) 67.0
N50 (bp) 54,916
Genome size (bp) 4,211,986

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3237

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1010308_0 Belongs to the UbiD family K03182 - 4.1.1.98 6.464e-300 938.0
TLS2_k127_1010308_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 481.0
TLS2_k127_1010308_10 Histidine kinase K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000674 181.0
TLS2_k127_1010308_11 - - - - 0.000000000000000001988 93.0
TLS2_k127_1010308_13 zinc-ribbon domain - - - 0.000000000009175 76.0
TLS2_k127_1010308_14 Protein of unknown function (DUF3667) - - - 0.000000006154 58.0
TLS2_k127_1010308_15 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0002962 53.0
TLS2_k127_1010308_2 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 396.0
TLS2_k127_1010308_3 response regulator K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 357.0
TLS2_k127_1010308_4 PepSY-associated TM region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 353.0
TLS2_k127_1010308_5 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002077 283.0
TLS2_k127_1010308_6 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001611 248.0
TLS2_k127_1010308_7 PFAM Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000005169 235.0
TLS2_k127_1010308_8 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000006331 185.0
TLS2_k127_1010308_9 MgtC SapB transporter K07507 - - 0.000000000000000000000000000000000000000000002697 169.0
TLS2_k127_1018959_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003786 283.0
TLS2_k127_1018959_1 membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000122 148.0
TLS2_k127_1083080_0 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009332 473.0
TLS2_k127_1083080_1 - - - - 0.00000000001233 70.0
TLS2_k127_1083080_2 TonB dependent receptor - - - 0.00000007157 65.0
TLS2_k127_1164480_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 3618.0
TLS2_k127_1164480_1 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1220.0
TLS2_k127_1164480_10 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 587.0
TLS2_k127_1164480_11 prohibitin homologues K07192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 500.0
TLS2_k127_1164480_12 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 444.0
TLS2_k127_1164480_13 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 447.0
TLS2_k127_1164480_14 Putative serine dehydratase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 422.0
TLS2_k127_1164480_15 Glycosyltransferase family 20 K03692 GO:0003674,GO:0003824,GO:0003825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034637,GO:0035251,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:1901576 2.4.1.213 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 407.0
TLS2_k127_1164480_16 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 402.0
TLS2_k127_1164480_17 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 402.0
TLS2_k127_1164480_18 conserved protein (DUF2183) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 312.0
TLS2_k127_1164480_19 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006279 302.0
TLS2_k127_1164480_2 metallocarboxypeptidase activity K14054 - - 0.0 1107.0
TLS2_k127_1164480_20 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 306.0
TLS2_k127_1164480_21 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 315.0
TLS2_k127_1164480_22 peroxidase activity K00435 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001805 272.0
TLS2_k127_1164480_23 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007002 258.0
TLS2_k127_1164480_24 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000006224 220.0
TLS2_k127_1164480_25 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000003482 187.0
TLS2_k127_1164480_26 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000000000000000000000000004858 166.0
TLS2_k127_1164480_27 ArsC family - - - 0.000000000000000000000000000000000000000006358 164.0
TLS2_k127_1164480_28 Glycosyltransferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 0.0000000000000000000000000000000000000000624 169.0
TLS2_k127_1164480_29 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000002013 147.0
TLS2_k127_1164480_3 PFAM Amino acid - - - 4.475e-277 914.0
TLS2_k127_1164480_30 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000002418 143.0
TLS2_k127_1164480_31 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000001034 114.0
TLS2_k127_1164480_33 - - - - 0.00000000000000000007748 95.0
TLS2_k127_1164480_34 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000001174 93.0
TLS2_k127_1164480_35 - - - - 0.000000000000002728 78.0
TLS2_k127_1164480_36 - - - - 0.0000000000008095 76.0
TLS2_k127_1164480_37 - - - - 0.0000000003799 67.0
TLS2_k127_1164480_38 Mechanosensitive ion channel - - - 0.0000000004804 70.0
TLS2_k127_1164480_39 - - - - 0.0000000436 64.0
TLS2_k127_1164480_4 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.413e-237 762.0
TLS2_k127_1164480_41 Universal stress protein - - - 0.0002295 53.0
TLS2_k127_1164480_5 Acyl-CoA oxidase K00232 - 1.3.3.6 4.028e-229 735.0
TLS2_k127_1164480_6 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.772e-224 711.0
TLS2_k127_1164480_7 TonB-dependent Receptor Plug Domain K02014 - - 3.883e-214 689.0
TLS2_k127_1164480_8 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 1.165e-206 647.0
TLS2_k127_1164480_9 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 598.0
TLS2_k127_1195258_0 Dienelactone hydrolase family - - - 2.311e-274 857.0
TLS2_k127_1195258_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008968 300.0
TLS2_k127_1195258_10 PIN domain - - - 0.0000000000000000000000000006174 118.0
TLS2_k127_1195258_11 23S rRNA-intervening sequence protein - - - 0.00000000008673 70.0
TLS2_k127_1195258_13 toxin-antitoxin pair type II binding - - - 0.00003125 52.0
TLS2_k127_1195258_14 N-Acetylmuramoyl-L-alanine amidase K01448 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783 3.5.1.28 0.00006543 49.0
TLS2_k127_1195258_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004433 280.0
TLS2_k127_1195258_3 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000193 216.0
TLS2_k127_1195258_4 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000004002 199.0
TLS2_k127_1195258_5 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000703 188.0
TLS2_k127_1195258_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000000000000000000000000000000001969 160.0
TLS2_k127_1195258_7 Sodium:solute symporter family K03307 - - 0.0000000000000000000000000000000000000000067 172.0
TLS2_k127_1195258_8 Glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.00000000000000000000000000000000000001253 151.0
TLS2_k127_1195258_9 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000003764 140.0
TLS2_k127_1244451_0 transport - - - 0.0 1144.0
TLS2_k127_1244451_1 GMC oxidoreductase - - - 1.179e-295 917.0
TLS2_k127_1244451_10 Periplasmic binding proteins and sugar binding domain of LacI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 413.0
TLS2_k127_1244451_11 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 396.0
TLS2_k127_1244451_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 385.0
TLS2_k127_1244451_13 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 372.0
TLS2_k127_1244451_14 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 375.0
TLS2_k127_1244451_15 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 338.0
TLS2_k127_1244451_16 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 316.0
TLS2_k127_1244451_17 Trypsin-like peptidase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 311.0
TLS2_k127_1244451_18 myo-inosose-2 dehydratase activity K03335,K15652 - 4.2.1.118,4.2.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001112 279.0
TLS2_k127_1244451_19 heme binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003776 260.0
TLS2_k127_1244451_2 PFAM ASPIC and UnbV - - - 3.814e-289 927.0
TLS2_k127_1244451_20 polysaccharide catabolic process K03478 - 3.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000004983 237.0
TLS2_k127_1244451_21 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000000000000000000000000000000000000000002088 229.0
TLS2_k127_1244451_22 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000000000000000000000000000000000000000000000002769 225.0
TLS2_k127_1244451_23 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000008529 233.0
TLS2_k127_1244451_24 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000000000000000005363 201.0
TLS2_k127_1244451_25 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000006832 189.0
TLS2_k127_1244451_26 Nitrogen regulatory protein P-II K04751 - - 0.0000000000000000000000000000000000000000000000002686 183.0
TLS2_k127_1244451_28 FCD domain - - - 0.0000000000000000000000000009153 123.0
TLS2_k127_1244451_29 - - - - 0.000000000000000000000001498 119.0
TLS2_k127_1244451_3 GMC oxidoreductase - - - 1.802e-271 846.0
TLS2_k127_1244451_30 FHA domain - - - 0.000000000000000000000002777 117.0
TLS2_k127_1244451_31 Acts as a magnesium transporter K06213 - - 0.00000000000000004601 81.0
TLS2_k127_1244451_32 - - - - 0.0000000001177 65.0
TLS2_k127_1244451_4 Peptidase family M1 domain K01256 - 3.4.11.2 3.011e-256 818.0
TLS2_k127_1244451_5 thymidine kinase activity K00857,K21572 - 2.7.1.21 1.792e-231 730.0
TLS2_k127_1244451_6 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 554.0
TLS2_k127_1244451_7 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 513.0
TLS2_k127_1244451_8 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 520.0
TLS2_k127_1244451_9 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 455.0
TLS2_k127_1331494_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1097.0
TLS2_k127_1331494_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.479e-259 815.0
TLS2_k127_1331494_10 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 493.0
TLS2_k127_1331494_11 AcrB/AcrD/AcrF family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 490.0
TLS2_k127_1331494_12 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 466.0
TLS2_k127_1331494_13 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008472 441.0
TLS2_k127_1331494_14 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 443.0
TLS2_k127_1331494_15 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 422.0
TLS2_k127_1331494_16 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 403.0
TLS2_k127_1331494_17 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 412.0
TLS2_k127_1331494_18 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005658 394.0
TLS2_k127_1331494_19 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 394.0
TLS2_k127_1331494_2 transmembrane transporter activity K03296 - - 3.048e-203 670.0
TLS2_k127_1331494_20 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 381.0
TLS2_k127_1331494_21 Bacterial dnaA protein K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 379.0
TLS2_k127_1331494_22 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 364.0
TLS2_k127_1331494_23 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007161 360.0
TLS2_k127_1331494_24 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 361.0
TLS2_k127_1331494_25 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 353.0
TLS2_k127_1331494_26 P2 response regulator binding domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 361.0
TLS2_k127_1331494_27 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 351.0
TLS2_k127_1331494_28 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 334.0
TLS2_k127_1331494_29 protoporphyrinogen oxidase K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 326.0
TLS2_k127_1331494_3 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 614.0
TLS2_k127_1331494_30 PFAM metal-dependent phosphohydrolase HD sub domain K09163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 299.0
TLS2_k127_1331494_31 Competence protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 317.0
TLS2_k127_1331494_32 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 294.0
TLS2_k127_1331494_33 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000615 297.0
TLS2_k127_1331494_34 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002393 285.0
TLS2_k127_1331494_35 TIGRFAM stage V sporulation protein E, cell division protein FtsW K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003607 284.0
TLS2_k127_1331494_36 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001104 257.0
TLS2_k127_1331494_37 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001142 265.0
TLS2_k127_1331494_38 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000001484 264.0
TLS2_k127_1331494_39 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000002008 263.0
TLS2_k127_1331494_4 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 610.0
TLS2_k127_1331494_40 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000004655 266.0
TLS2_k127_1331494_41 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K00950,K01633 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000000000000000000000000001871 260.0
TLS2_k127_1331494_42 proline dipeptidase activity K01262 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000003732 265.0
TLS2_k127_1331494_43 EamA-like transporter family K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000527 254.0
TLS2_k127_1331494_44 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000000000009984 249.0
TLS2_k127_1331494_45 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000001609 245.0
TLS2_k127_1331494_46 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000004039 246.0
TLS2_k127_1331494_47 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000001796 243.0
TLS2_k127_1331494_48 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000006851 226.0
TLS2_k127_1331494_49 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000001607 224.0
TLS2_k127_1331494_5 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000732 580.0
TLS2_k127_1331494_50 cheY-homologous receiver domain K03413 - - 0.00000000000000000000000000000000000000000000000000000001763 199.0
TLS2_k127_1331494_51 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000001109 203.0
TLS2_k127_1331494_52 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000006983 203.0
TLS2_k127_1331494_53 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000003719 204.0
TLS2_k127_1331494_54 Cysteine-rich motif following a subset of SET domains K07117 - - 0.0000000000000000000000000000000000000000000000000002241 188.0
TLS2_k127_1331494_55 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075,K15780 - 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000000000000000006776 198.0
TLS2_k127_1331494_56 Biotin-lipoyl like K03585 - - 0.0000000000000000000000000000000000000000000000001468 195.0
TLS2_k127_1331494_57 Diacylglycerol kinase catalytic domain (presumed) - - - 0.00000000000000000000000000000000000000000000002105 183.0
TLS2_k127_1331494_58 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000000000000000000000006329 185.0
TLS2_k127_1331494_59 CheC-like family K03410 - - 0.000000000000000000000000000000000000000000007634 174.0
TLS2_k127_1331494_6 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 529.0
TLS2_k127_1331494_60 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000000000001161 164.0
TLS2_k127_1331494_61 - - - - 0.00000000000000000000000000000000000000002837 167.0
TLS2_k127_1331494_62 MotA/TolQ/ExbB proton channel family K03561 - - 0.000000000000000000000000000000000000001272 157.0
TLS2_k127_1331494_63 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000004856 144.0
TLS2_k127_1331494_64 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000000000000006802 138.0
TLS2_k127_1331494_65 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000001695 143.0
TLS2_k127_1331494_66 - - - - 0.000000000000000000000000000000007491 133.0
TLS2_k127_1331494_67 - - - - 0.0000000000000000000000000000008202 121.0
TLS2_k127_1331494_68 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.0000000000000000000000000001017 125.0
TLS2_k127_1331494_69 CAAX protease self-immunity K07052 - - 0.000000000000000000000000003145 122.0
TLS2_k127_1331494_7 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 515.0
TLS2_k127_1331494_70 BioY family K03523 - - 0.0000000000000000000004898 103.0
TLS2_k127_1331494_71 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000001318 108.0
TLS2_k127_1331494_72 biopolymer transport protein K03559 - - 0.00000000000000000001655 96.0
TLS2_k127_1331494_73 - - - - 0.00000000000000000002914 104.0
TLS2_k127_1331494_74 HD domain - - - 0.000000000000000001974 96.0
TLS2_k127_1331494_75 biopolymer transport protein K03559 - - 0.000000000000007721 82.0
TLS2_k127_1331494_76 Metallo-beta-lactamase superfamily - - - 0.00000000000002253 74.0
TLS2_k127_1331494_77 TonB C terminal K03832 - - 0.00000000000204 76.0
TLS2_k127_1331494_78 Tetratricopeptide repeat - - - 0.000000000003999 79.0
TLS2_k127_1331494_79 PFAM DivIVA K04074 - - 0.00000000001787 77.0
TLS2_k127_1331494_8 C4-dicarboxylate anaerobic carrier - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 503.0
TLS2_k127_1331494_80 - - - - 0.0000000001072 70.0
TLS2_k127_1331494_81 zinc ion binding - - - 0.0000000002404 72.0
TLS2_k127_1331494_82 Tetratricopeptide repeat - - - 0.000000002311 68.0
TLS2_k127_1331494_83 PFAM CheW domain protein K03408 - - 0.0000009138 59.0
TLS2_k127_1331494_84 Roadblock/LC7 domain - - - 0.000003005 57.0
TLS2_k127_1331494_85 Roadblock/LC7 domain K07131 - - 0.00000509 53.0
TLS2_k127_1331494_86 Cell division protein FtsQ K03589 - - 0.000007165 57.0
TLS2_k127_1331494_87 ZnF_NFX K12236 GO:0000122,GO:0000976,GO:0000977,GO:0000981,GO:0000982,GO:0001012,GO:0001067,GO:0001078,GO:0001227,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009416,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009636,GO:0009642,GO:0009651,GO:0009696,GO:0009697,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010188,GO:0010310,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010817,GO:0016053,GO:0016070,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0018958,GO:0019219,GO:0019222,GO:0019438,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042445,GO:0042446,GO:0042537,GO:0042742,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045892,GO:0045934,GO:0046189,GO:0046394,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051193,GO:0051252,GO:0051253,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098542,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901615,GO:1901617,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000377,GO:2001141 - 0.000007386 57.0
TLS2_k127_1331494_88 Septum formation initiator K05589 - - 0.0000132 56.0
TLS2_k127_1331494_89 RND efflux system, outer membrane lipoprotein - - - 0.00005678 56.0
TLS2_k127_1331494_9 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 495.0
TLS2_k127_1351894_0 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0 1108.0
TLS2_k127_1351894_1 efflux transmembrane transporter activity - - - 5.514e-244 791.0
TLS2_k127_1351894_10 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 493.0
TLS2_k127_1351894_11 esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 477.0
TLS2_k127_1351894_12 Protein of unknown function (DUF3500) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 462.0
TLS2_k127_1351894_13 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 472.0
TLS2_k127_1351894_14 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 457.0
TLS2_k127_1351894_15 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007646 413.0
TLS2_k127_1351894_16 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009049 370.0
TLS2_k127_1351894_17 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 348.0
TLS2_k127_1351894_18 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 325.0
TLS2_k127_1351894_19 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000004473 241.0
TLS2_k127_1351894_2 TonB dependent receptor - - - 1.337e-200 661.0
TLS2_k127_1351894_20 SusD family K21572 - - 0.00000000000000000000000000000000000000000000000000000000000000642 231.0
TLS2_k127_1351894_21 Domain of unknown function (DUF4287) - - - 0.00000000000000000000000000000000000000000000000000000000000007606 218.0
TLS2_k127_1351894_22 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000001399 183.0
TLS2_k127_1351894_23 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000000007707 168.0
TLS2_k127_1351894_24 YCII-related domain - - - 0.0000000000000000000000000000000000000004083 152.0
TLS2_k127_1351894_25 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000007982 151.0
TLS2_k127_1351894_26 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000001096 138.0
TLS2_k127_1351894_27 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000001499 139.0
TLS2_k127_1351894_28 oligosaccharyl transferase activity K07151 - 2.4.99.18 0.000000000000000000000000000000001071 150.0
TLS2_k127_1351894_29 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000004431 130.0
TLS2_k127_1351894_3 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 593.0
TLS2_k127_1351894_30 Protein of unknown function (DUF1761) - - - 0.00000000000000000000000000000001983 131.0
TLS2_k127_1351894_31 - - - - 0.0000000000000000000000000000002312 134.0
TLS2_k127_1351894_32 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000002653 130.0
TLS2_k127_1351894_33 Transcriptional regulator - - - 0.0000000000000000000000000000006152 141.0
TLS2_k127_1351894_34 - - - - 0.0000000000000000000000007804 116.0
TLS2_k127_1351894_35 Cysteine-rich CPXCG - - - 0.00000000000000000002488 99.0
TLS2_k127_1351894_36 negative regulation of transcription, DNA-templated - - - 0.0000000000000000004419 91.0
TLS2_k127_1351894_37 Glycogen recognition site of AMP-activated protein kinase - - - 0.00000000000000001874 91.0
TLS2_k127_1351894_38 - - - - 0.0000000000000008313 87.0
TLS2_k127_1351894_39 - - - - 0.000000000000004539 87.0
TLS2_k127_1351894_4 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008249 593.0
TLS2_k127_1351894_40 - - - - 0.000000000000006675 85.0
TLS2_k127_1351894_41 - - - - 0.0000000002239 72.0
TLS2_k127_1351894_42 WD40-like Beta Propeller Repeat - - - 0.000000000783 69.0
TLS2_k127_1351894_43 YCII-related domain - - - 0.000001405 55.0
TLS2_k127_1351894_44 efflux transmembrane transporter activity - - - 0.000001994 54.0
TLS2_k127_1351894_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 564.0
TLS2_k127_1351894_6 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 538.0
TLS2_k127_1351894_7 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 533.0
TLS2_k127_1351894_8 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 527.0
TLS2_k127_1351894_9 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000857 502.0
TLS2_k127_1370114_0 DNA topoisomerase II activity K02469 - 5.99.1.3 0.0 1017.0
TLS2_k127_1370114_1 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004346 275.0
TLS2_k127_1370114_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000004897 275.0
TLS2_k127_1370114_3 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000002028 189.0
TLS2_k127_1370114_4 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000002453 176.0
TLS2_k127_1370114_5 PFAM DSBA oxidoreductase - - - 0.00000000000000000000000000000000000001286 155.0
TLS2_k127_1370114_6 Vitamin K epoxide reductase family - - - 0.0000000000000000000000001035 114.0
TLS2_k127_1451015_0 Cysteine synthase K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 375.0
TLS2_k127_1451015_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005869 314.0
TLS2_k127_1451015_2 transporter family K12942 - - 0.000000000000000000000000000000000000000000000000000000005546 206.0
TLS2_k127_1451015_3 - - - - 0.00000000000000000000000000000000000002634 151.0
TLS2_k127_1459503_0 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 3.387e-317 990.0
TLS2_k127_1459503_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 2.109e-203 640.0
TLS2_k127_1459503_10 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006894 406.0
TLS2_k127_1459503_11 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 368.0
TLS2_k127_1459503_12 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 332.0
TLS2_k127_1459503_13 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 316.0
TLS2_k127_1459503_14 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 301.0
TLS2_k127_1459503_15 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 299.0
TLS2_k127_1459503_16 MacB-like periplasmic core domain K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006329 298.0
TLS2_k127_1459503_17 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000053 286.0
TLS2_k127_1459503_18 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001183 289.0
TLS2_k127_1459503_19 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009707 271.0
TLS2_k127_1459503_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007659 620.0
TLS2_k127_1459503_20 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000006991 239.0
TLS2_k127_1459503_21 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000008397 249.0
TLS2_k127_1459503_22 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000624 232.0
TLS2_k127_1459503_23 Bacillithiol biosynthesis BshC K22136 - - 0.00000000000000000000000000000000000000000000000000000001526 218.0
TLS2_k127_1459503_24 COG1625 Fe-S oxidoreductase related to NifB MoaA family - - - 0.00000000000000000000000000000000000000000008252 165.0
TLS2_k127_1459503_25 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000000000002906 165.0
TLS2_k127_1459503_26 UvrB/uvrC motif K19411 - - 0.0000000000000000000000000000000000006853 145.0
TLS2_k127_1459503_27 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000001416 139.0
TLS2_k127_1459503_28 - - - - 0.0000000000000000000000000000000003241 143.0
TLS2_k127_1459503_29 Trm112p-like protein K09791 - - 0.000000000000000000004142 93.0
TLS2_k127_1459503_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 579.0
TLS2_k127_1459503_30 Belongs to the skp family K06142 - - 0.000000001824 66.0
TLS2_k127_1459503_31 Putative prokaryotic signal transducing protein - - - 0.000002193 56.0
TLS2_k127_1459503_4 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 581.0
TLS2_k127_1459503_5 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004059 552.0
TLS2_k127_1459503_6 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008305 485.0
TLS2_k127_1459503_7 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 441.0
TLS2_k127_1459503_8 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 429.0
TLS2_k127_1459503_9 ATP:guanido phosphotransferase, C-terminal catalytic domain K19405 - 2.7.14.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 417.0
TLS2_k127_1518964_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 603.0
TLS2_k127_1518964_1 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity K00697,K13057,K20436 - 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 458.0
TLS2_k127_1518964_2 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008696 452.0
TLS2_k127_1518964_3 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 398.0
TLS2_k127_1518964_4 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 346.0
TLS2_k127_1518964_5 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005814 285.0
TLS2_k127_1518964_6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000001239 186.0
TLS2_k127_1518964_7 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000003781 106.0
TLS2_k127_1518964_9 hydrocarbon binding protein (contains V4R domain) K07013 - - 0.00001961 53.0
TLS2_k127_1528772_0 ATP-dependent helicase K03579 - 3.6.4.13 5.123e-285 899.0
TLS2_k127_1528772_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 618.0
TLS2_k127_1528772_2 ATPase of the ABC class - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 567.0
TLS2_k127_1528772_3 Nitrite reductase K00368,K08100 - 1.3.3.5,1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 474.0
TLS2_k127_1528772_4 Lipocalin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 377.0
TLS2_k127_1528772_5 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002502 281.0
TLS2_k127_1528772_6 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009168 254.0
TLS2_k127_1528772_7 Transcriptional regulator - - - 0.000000000000000000000000183 110.0
TLS2_k127_1528772_8 BON domain - - - 0.0002042 49.0
TLS2_k127_1584055_0 4Fe-4S dicluster domain K00184 - - 6.165e-225 733.0
TLS2_k127_1584055_1 acyl-CoA dehydrogenase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 1.595e-208 665.0
TLS2_k127_1584055_10 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008155 297.0
TLS2_k127_1584055_11 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005509 291.0
TLS2_k127_1584055_12 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000005481 283.0
TLS2_k127_1584055_13 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006891 269.0
TLS2_k127_1584055_14 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001186 243.0
TLS2_k127_1584055_15 Pfam Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000013 235.0
TLS2_k127_1584055_16 Acyl-CoA reductase (LuxC) - - - 0.0000000000000000000000000000000000000000000000000000000000002387 229.0
TLS2_k127_1584055_17 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000004008 205.0
TLS2_k127_1584055_18 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.000000000000000000000000000000000000000000000000004935 196.0
TLS2_k127_1584055_19 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000005455 192.0
TLS2_k127_1584055_2 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 617.0
TLS2_k127_1584055_20 - - - - 0.00000000000000000000000000000000000000000000000001957 197.0
TLS2_k127_1584055_21 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 0.0000000000000000000000000000000000000000000002139 179.0
TLS2_k127_1584055_22 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000001846 171.0
TLS2_k127_1584055_23 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000002868 164.0
TLS2_k127_1584055_24 Tetratricopeptide repeat K08309 - - 0.0000000000000000000000000000000000000000005162 181.0
TLS2_k127_1584055_25 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000008309 162.0
TLS2_k127_1584055_26 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - 0.00000000000000000000000000000000000000004475 154.0
TLS2_k127_1584055_27 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000003321 136.0
TLS2_k127_1584055_28 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000006736 147.0
TLS2_k127_1584055_29 Gas vesicle protein K - - - 0.00000000000000000000000000000001392 134.0
TLS2_k127_1584055_3 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 565.0
TLS2_k127_1584055_31 Cold shock K03704 - - 0.000000000000000000000000000236 115.0
TLS2_k127_1584055_32 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.0000000000000000000000000005052 117.0
TLS2_k127_1584055_33 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.0000000000000000000000000132 112.0
TLS2_k127_1584055_34 Gas vesicle - - - 0.000000000000000000000005506 111.0
TLS2_k127_1584055_35 lytic transglycosylase activity - - - 0.0000000000000003703 89.0
TLS2_k127_1584055_36 RNA-binding protein, YhbY family K07574 - - 0.0000000000000006732 85.0
TLS2_k127_1584055_37 Transglycosylase SLT domain - - - 0.000000000000001362 85.0
TLS2_k127_1584055_38 PFAM Cytochrome C - - - 0.0000000000003239 78.0
TLS2_k127_1584055_4 protein histidine kinase activity K03407,K07678 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 565.0
TLS2_k127_1584055_40 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00001383 49.0
TLS2_k127_1584055_5 Acyl-CoA dehydrogenase, C-terminal domain K00248,K09478 - 1.3.8.1,1.3.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 467.0
TLS2_k127_1584055_6 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005467 440.0
TLS2_k127_1584055_7 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 431.0
TLS2_k127_1584055_8 heat shock protein binding K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 378.0
TLS2_k127_1584055_9 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 369.0
TLS2_k127_1691633_0 PFAM Beta-ketoacyl synthase, N-terminal - - - 0.0 1619.0
TLS2_k127_1691633_1 acyl transferase domain - - - 0.0 1395.0
TLS2_k127_1691633_10 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 9.367e-194 621.0
TLS2_k127_1691633_11 Putative glucoamylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 593.0
TLS2_k127_1691633_12 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 524.0
TLS2_k127_1691633_13 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 506.0
TLS2_k127_1691633_14 COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 533.0
TLS2_k127_1691633_15 ABC transporter substrate-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 444.0
TLS2_k127_1691633_16 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 434.0
TLS2_k127_1691633_17 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 414.0
TLS2_k127_1691633_18 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 423.0
TLS2_k127_1691633_19 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 410.0
TLS2_k127_1691633_2 acyl transferase domain - - - 0.0 1340.0
TLS2_k127_1691633_20 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007 403.0
TLS2_k127_1691633_21 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 378.0
TLS2_k127_1691633_22 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 372.0
TLS2_k127_1691633_23 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007274 342.0
TLS2_k127_1691633_24 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009131 337.0
TLS2_k127_1691633_25 LacI family K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 333.0
TLS2_k127_1691633_26 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 326.0
TLS2_k127_1691633_27 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 295.0
TLS2_k127_1691633_28 PaaX-like protein K02616 - - 0.0000000000000000000000000000000000000000000000000000000000000000005085 239.0
TLS2_k127_1691633_29 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000000006852 221.0
TLS2_k127_1691633_3 Linear gramicidin synthase subunit - - - 0.0 1254.0
TLS2_k127_1691633_30 - - - - 0.00000000000000000000000000000000000000000000000001154 198.0
TLS2_k127_1691633_31 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000001506 184.0
TLS2_k127_1691633_32 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000004338 177.0
TLS2_k127_1691633_33 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000002358 168.0
TLS2_k127_1691633_34 TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated - - - 0.0000000000000000000000000000000000001609 153.0
TLS2_k127_1691633_35 anaerobic respiration K02568 - - 0.0000000000000000000000000000000000007407 151.0
TLS2_k127_1691633_37 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000006619 143.0
TLS2_k127_1691633_38 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000000001794 136.0
TLS2_k127_1691633_39 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000003094 134.0
TLS2_k127_1691633_4 COG3321 Polyketide synthase modules and related proteins - - - 0.0 1180.0
TLS2_k127_1691633_40 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000007913 113.0
TLS2_k127_1691633_41 - - - - 0.000000000000000000000001448 114.0
TLS2_k127_1691633_42 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000004713 103.0
TLS2_k127_1691633_43 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000000000000007687 108.0
TLS2_k127_1691633_44 EamA-like transporter family - - - 0.00000000000003896 83.0
TLS2_k127_1691633_45 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.000000000004554 67.0
TLS2_k127_1691633_46 heat shock protein binding - - - 0.000000001149 68.0
TLS2_k127_1691633_5 COG3321 Polyketide synthase modules and related proteins - - - 0.0 1070.0
TLS2_k127_1691633_6 Glycosyltransferase 36 associated - - - 0.0 1041.0
TLS2_k127_1691633_7 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 2.681e-300 933.0
TLS2_k127_1691633_8 COG3321 Polyketide synthase modules and related proteins - - - 1.206e-268 882.0
TLS2_k127_1691633_9 TonB dependent receptor - - - 9.982e-206 674.0
TLS2_k127_1729568_0 - - - - 0.000000000000000000000000000000000008753 145.0
TLS2_k127_1881993_0 efflux transmembrane transporter activity - - - 4.599e-261 836.0
TLS2_k127_1881993_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 523.0
TLS2_k127_1881993_10 DinB superfamily - - - 0.00000000000000000000000000000000000000000002485 167.0
TLS2_k127_1881993_11 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000001485 158.0
TLS2_k127_1881993_12 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000000001104 156.0
TLS2_k127_1881993_13 transcriptional regulator - - - 0.0000000000000000000000000000000000000002837 152.0
TLS2_k127_1881993_14 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.000000000000000000000000000000000000001884 162.0
TLS2_k127_1881993_15 WD40 domain protein beta Propeller K03641 - - 0.00000000000000000000000000000001443 141.0
TLS2_k127_1881993_16 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000009996 121.0
TLS2_k127_1881993_17 PaaX-like protein K02616 - - 0.000000000000000000000002814 120.0
TLS2_k127_1881993_18 Transcriptional regulator, ArsR family - - - 0.000000000000000000000019 103.0
TLS2_k127_1881993_19 FCD - - - 0.00000000000000000000006801 107.0
TLS2_k127_1881993_2 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000781 464.0
TLS2_k127_1881993_20 - - - - 0.00000000000000000000121 108.0
TLS2_k127_1881993_21 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000002331 108.0
TLS2_k127_1881993_22 MacB-like periplasmic core domain - - - 0.00000000000000000001428 98.0
TLS2_k127_1881993_23 alpha beta K06889 - - 0.0000000000000000005807 100.0
TLS2_k127_1881993_24 Sugar-specific transcriptional regulator TrmB - - - 0.00000000001075 75.0
TLS2_k127_1881993_25 Transcriptional regulator, GntR family - - - 0.00000000002659 74.0
TLS2_k127_1881993_26 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000005103 68.0
TLS2_k127_1881993_28 Conserved TM helix - - - 0.0000000003257 71.0
TLS2_k127_1881993_29 - - - - 0.00000000191 69.0
TLS2_k127_1881993_3 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 417.0
TLS2_k127_1881993_30 OmpA family - - - 0.00000003828 60.0
TLS2_k127_1881993_31 helix_turn_helix, Lux Regulon K03556 - - 0.00000008636 63.0
TLS2_k127_1881993_32 PIN domain K07064 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944 - 0.0000005062 57.0
TLS2_k127_1881993_33 Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane - - - 0.0000005668 61.0
TLS2_k127_1881993_34 positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.000006537 52.0
TLS2_k127_1881993_35 MgtE intracellular N domain - - - 0.00001048 57.0
TLS2_k127_1881993_36 efflux transmembrane transporter activity K02004 - - 0.00002035 53.0
TLS2_k127_1881993_37 gag-polyprotein putative aspartyl protease - - - 0.0004348 53.0
TLS2_k127_1881993_38 Aspartyl protease K06985 - - 0.0008571 51.0
TLS2_k127_1881993_4 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 386.0
TLS2_k127_1881993_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 374.0
TLS2_k127_1881993_6 Beta-lactamase superfamily domain K06136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 338.0
TLS2_k127_1881993_7 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000007206 228.0
TLS2_k127_1881993_8 Dienelactone hydrolase-like enzyme - - - 0.0000000000000000000000000000000000000000000000000000000001339 215.0
TLS2_k127_1881993_9 Rhomboid family - - - 0.00000000000000000000000000000000000000000000002023 175.0
TLS2_k127_1923227_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1150.0
TLS2_k127_1923227_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 1.87e-230 742.0
TLS2_k127_1923227_10 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000009769 233.0
TLS2_k127_1923227_11 Histidine biosynthesis protein K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000004832 230.0
TLS2_k127_1923227_12 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000001189 212.0
TLS2_k127_1923227_13 EAL domain - - - 0.000000000000000000000000000000000000000000000000002299 203.0
TLS2_k127_1923227_14 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000005168 177.0
TLS2_k127_1923227_15 SMART chemotaxis sensory transducer, histidine kinase HAMP region domain protein K03406 - - 0.000000000000000000000000000000000000000000002388 184.0
TLS2_k127_1923227_16 Domain of unknown function (DUF1707) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000004917 148.0
TLS2_k127_1923227_17 phosphorelay signal transduction system - - - 0.000000000000000000000000000000005811 137.0
TLS2_k127_1923227_18 membrane - - - 0.000000000000000000000000003183 112.0
TLS2_k127_1923227_19 Phospholipase_D-nuclease N-terminal - - - 0.0001479 46.0
TLS2_k127_1923227_2 ABC transporter transmembrane region K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 580.0
TLS2_k127_1923227_3 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008422 369.0
TLS2_k127_1923227_4 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 354.0
TLS2_k127_1923227_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 339.0
TLS2_k127_1923227_6 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 312.0
TLS2_k127_1923227_7 EAL domain K13950,K21025 - 2.6.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001218 293.0
TLS2_k127_1923227_8 PFAM inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002215 279.0
TLS2_k127_1923227_9 Alpha/beta hydrolase family K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007558 273.0
TLS2_k127_192854_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.175e-280 886.0
TLS2_k127_192854_1 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 9.819e-279 886.0
TLS2_k127_192854_10 MarR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 443.0
TLS2_k127_192854_11 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 431.0
TLS2_k127_192854_12 Belongs to the D-alanine--D-alanine ligase family K01921 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 410.0
TLS2_k127_192854_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 416.0
TLS2_k127_192854_14 serine-type peptidase activity K01278 - 3.4.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 391.0
TLS2_k127_192854_15 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008007 342.0
TLS2_k127_192854_16 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008142 336.0
TLS2_k127_192854_17 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001844 280.0
TLS2_k127_192854_18 SusD family K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003499 276.0
TLS2_k127_192854_19 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001816 266.0
TLS2_k127_192854_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 2.876e-242 770.0
TLS2_k127_192854_20 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000144 255.0
TLS2_k127_192854_21 TonB-dependent receptor plug K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000102 242.0
TLS2_k127_192854_22 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000002088 210.0
TLS2_k127_192854_23 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000001121 187.0
TLS2_k127_192854_24 Protein of unknown function (DUF1572) - - - 0.00000000000000000000000000000000000004072 152.0
TLS2_k127_192854_25 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000003712 155.0
TLS2_k127_192854_26 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000288 137.0
TLS2_k127_192854_27 Response regulator, receiver K11443 - - 0.000000000000000000000000004204 117.0
TLS2_k127_192854_28 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000815 118.0
TLS2_k127_192854_29 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000006077 117.0
TLS2_k127_192854_3 Elongation factor G, domain IV K02355 - - 1.198e-232 739.0
TLS2_k127_192854_30 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000689 111.0
TLS2_k127_192854_31 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000002372 104.0
TLS2_k127_192854_32 Gas vesicle synthesis protein GvpL/GvpF - - - 0.0000000000000000007686 97.0
TLS2_k127_192854_33 - - - - 0.00000000000000009465 81.0
TLS2_k127_192854_34 - - - - 0.0000000000001014 78.0
TLS2_k127_192854_35 nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.0000000000007485 81.0
TLS2_k127_192854_36 Rieske-like [2Fe-2S] domain K05710,K18087 - - 0.00000000001685 70.0
TLS2_k127_192854_37 overlaps another CDS with the same product name - - - 0.0000000001046 73.0
TLS2_k127_192854_38 Membrane - - - 0.00000001089 63.0
TLS2_k127_192854_39 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000162 55.0
TLS2_k127_192854_4 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 616.0
TLS2_k127_192854_40 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - 0.00002547 56.0
TLS2_k127_192854_5 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 588.0
TLS2_k127_192854_6 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007114 530.0
TLS2_k127_192854_7 Domain of unknown function (DUF5117) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 505.0
TLS2_k127_192854_8 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 458.0
TLS2_k127_192854_9 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 465.0
TLS2_k127_2012105_0 Glycosyl hydrolase family 9 - - - 0.0 1131.0
TLS2_k127_2012105_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 483.0
TLS2_k127_2012105_10 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001449 254.0
TLS2_k127_2012105_11 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003392 252.0
TLS2_k127_2012105_12 HD domain K07023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009673 241.0
TLS2_k127_2012105_13 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000009669 211.0
TLS2_k127_2012105_14 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000007667 206.0
TLS2_k127_2012105_15 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000008059 202.0
TLS2_k127_2012105_16 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000000004192 198.0
TLS2_k127_2012105_17 OmpA family - - - 0.00000000000000000000000000000000000000000000000002335 186.0
TLS2_k127_2012105_18 acetyltransferase - - - 0.000000000000000000000000000000004603 136.0
TLS2_k127_2012105_19 - - - - 0.000000000000000000000000000000009511 140.0
TLS2_k127_2012105_2 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 442.0
TLS2_k127_2012105_20 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000001912 129.0
TLS2_k127_2012105_21 - - - - 0.0000000000000000002581 99.0
TLS2_k127_2012105_22 Methyltransferase FkbM domain - - - 0.0000000000000000004367 98.0
TLS2_k127_2012105_3 Glycosyl hydrolases family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 410.0
TLS2_k127_2012105_4 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 405.0
TLS2_k127_2012105_5 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 348.0
TLS2_k127_2012105_6 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008392 302.0
TLS2_k127_2012105_7 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 293.0
TLS2_k127_2012105_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002726 287.0
TLS2_k127_2012105_9 epimerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000174 266.0
TLS2_k127_2017847_0 abc transporter atp-binding protein K06147 - - 1.09e-300 932.0
TLS2_k127_2017847_1 Dienelactone hydrolase family - - - 3.424e-287 911.0
TLS2_k127_2017847_10 Amidohydrolase family K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008135 445.0
TLS2_k127_2017847_11 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 360.0
TLS2_k127_2017847_12 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 339.0
TLS2_k127_2017847_13 mannose-ethanolamine phosphotransferase activity K01077 GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 334.0
TLS2_k127_2017847_14 Belongs to the GHMP kinase family K00849 - 2.7.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 306.0
TLS2_k127_2017847_15 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000006194 226.0
TLS2_k127_2017847_16 Dihydrofolate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000001467 218.0
TLS2_k127_2017847_17 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000001605 220.0
TLS2_k127_2017847_18 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000002526 198.0
TLS2_k127_2017847_19 NUDIX hydrolase - - - 0.000000000000000000000000000000000000000007216 165.0
TLS2_k127_2017847_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 8.535e-270 839.0
TLS2_k127_2017847_20 DinB superfamily K07552 - - 0.00000000000000000000000000000000000000005927 159.0
TLS2_k127_2017847_21 Domain of unknown function (DUF4956) - - - 0.0000000000000000000000294 114.0
TLS2_k127_2017847_23 - - - - 0.000000000003013 76.0
TLS2_k127_2017847_24 protein involved in outer membrane biogenesis K07289 - - 0.000000001567 72.0
TLS2_k127_2017847_3 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.447e-239 794.0
TLS2_k127_2017847_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 4.164e-236 744.0
TLS2_k127_2017847_5 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 5.784e-198 627.0
TLS2_k127_2017847_6 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 561.0
TLS2_k127_2017847_7 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 539.0
TLS2_k127_2017847_8 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 462.0
TLS2_k127_2017847_9 membrane organization - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 467.0
TLS2_k127_2075066_0 Dienelactone hydrolase family - - - 0.0 1042.0
TLS2_k127_2075066_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.887e-288 898.0
TLS2_k127_2075066_10 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007719 591.0
TLS2_k127_2075066_11 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 580.0
TLS2_k127_2075066_12 glutamate-cysteine ligase activity K00836 - 2.6.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 555.0
TLS2_k127_2075066_13 Domain of unknown function (DUF3471) K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 537.0
TLS2_k127_2075066_14 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 535.0
TLS2_k127_2075066_15 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 552.0
TLS2_k127_2075066_16 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 509.0
TLS2_k127_2075066_17 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 503.0
TLS2_k127_2075066_18 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 503.0
TLS2_k127_2075066_19 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 490.0
TLS2_k127_2075066_2 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 2.384e-286 906.0
TLS2_k127_2075066_20 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 465.0
TLS2_k127_2075066_21 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 455.0
TLS2_k127_2075066_22 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 437.0
TLS2_k127_2075066_23 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 426.0
TLS2_k127_2075066_24 Domain of unknown function (DUF3471) K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 423.0
TLS2_k127_2075066_25 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 376.0
TLS2_k127_2075066_26 Bacterial protein of unknown function (DUF839) K07093 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 381.0
TLS2_k127_2075066_27 esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 327.0
TLS2_k127_2075066_28 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005786 305.0
TLS2_k127_2075066_29 Putative esterase K07017 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 289.0
TLS2_k127_2075066_3 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - 1.778e-280 887.0
TLS2_k127_2075066_30 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 315.0
TLS2_k127_2075066_31 choline dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004303 292.0
TLS2_k127_2075066_32 Amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007774 282.0
TLS2_k127_2075066_33 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000602 287.0
TLS2_k127_2075066_34 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002982 273.0
TLS2_k127_2075066_35 RES - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008264 274.0
TLS2_k127_2075066_36 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001534 287.0
TLS2_k127_2075066_37 Glycosyltransferase Family 4 K14335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001629 273.0
TLS2_k127_2075066_38 Phospholipase/Carboxylesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002741 251.0
TLS2_k127_2075066_39 Glutamate-cysteine ligase family 2(GCS2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000004916 266.0
TLS2_k127_2075066_4 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 6.765e-264 818.0
TLS2_k127_2075066_40 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000001138 241.0
TLS2_k127_2075066_41 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000001586 237.0
TLS2_k127_2075066_42 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000006069 233.0
TLS2_k127_2075066_43 metal cluster binding K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000005461 217.0
TLS2_k127_2075066_44 - - - - 0.00000000000000000000000000000000000000000000000000000000001516 215.0
TLS2_k127_2075066_45 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000000000000000000006092 199.0
TLS2_k127_2075066_46 Cupin domain - - - 0.0000000000000000000000000000000000000000000000001013 185.0
TLS2_k127_2075066_47 PFAM phospholipase Carboxylesterase - - - 0.000000000000000000000000000000000000000000000001994 181.0
TLS2_k127_2075066_48 Protein of unknown function (DUF2384) - - - 0.0000000000000000000000000000000000000000001141 168.0
TLS2_k127_2075066_49 Ferredoxin - - - 0.00000000000000000000000000000000000006599 146.0
TLS2_k127_2075066_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 1.24e-262 828.0
TLS2_k127_2075066_50 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000002703 132.0
TLS2_k127_2075066_51 solute sodium symporter, small subunit - - - 0.00000000000000000000000000000006552 128.0
TLS2_k127_2075066_52 Thioredoxin-like K02199 - - 0.000000000000000000000000000001299 131.0
TLS2_k127_2075066_53 lysyltransferase activity K07027 - - 0.0000000000000000000000005465 119.0
TLS2_k127_2075066_54 glycosyl transferase - - - 0.00005272 48.0
TLS2_k127_2075066_55 Diguanylate cyclase K02488 - 2.7.7.65 0.0007787 50.0
TLS2_k127_2075066_6 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 7.428e-252 792.0
TLS2_k127_2075066_7 Amidohydrolase family K06015 - 3.5.1.81 8.787e-252 786.0
TLS2_k127_2075066_8 peptidase activity - - - 3.6e-233 739.0
TLS2_k127_2075066_9 Amidohydrolase family K06015 - 3.5.1.81 2.225e-229 724.0
TLS2_k127_2101576_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 533.0
TLS2_k127_2101576_1 negative regulation of transcription, DNA-templated - - - 0.000000000000006484 80.0
TLS2_k127_2101576_2 amine dehydrogenase activity - - - 0.0002346 53.0
TLS2_k127_2117231_0 PA14 domain K05349 - 3.2.1.21 0.0 1052.0
TLS2_k127_2117231_1 TonB dependent receptor - - - 0.0 1028.0
TLS2_k127_2117231_10 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001543 275.0
TLS2_k127_2117231_11 membrane K07148 - - 0.000000000000000000000000000000000000000000000000000000000000000001753 251.0
TLS2_k127_2117231_12 ATPases associated with a variety of cellular activities K05847 - - 0.00000000000000000000000000000000000000000000000000000000000007324 224.0
TLS2_k127_2117231_13 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000003916 211.0
TLS2_k127_2117231_14 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.00000000000000000000000000000000000003135 148.0
TLS2_k127_2117231_15 DinB family - - - 0.0000000000000000000000000000000000002574 147.0
TLS2_k127_2117231_16 - - - - 0.00000000000000000000000000005246 126.0
TLS2_k127_2117231_17 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000001033 116.0
TLS2_k127_2117231_18 methyltransferase - - - 0.000000000000000000000003731 119.0
TLS2_k127_2117231_19 WD40-like Beta Propeller Repeat - - - 0.00000001928 60.0
TLS2_k127_2117231_2 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 362.0
TLS2_k127_2117231_20 DNA-sulfur modification-associated - - - 0.0002878 52.0
TLS2_k127_2117231_3 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 353.0
TLS2_k127_2117231_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 339.0
TLS2_k127_2117231_5 SusD family K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 333.0
TLS2_k127_2117231_6 Glycine betaine K05845 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 335.0
TLS2_k127_2117231_7 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 349.0
TLS2_k127_2117231_8 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 346.0
TLS2_k127_2117231_9 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 301.0
TLS2_k127_2138476_0 efflux transmembrane transporter activity K02004 - - 0.0 1116.0
TLS2_k127_2138476_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 436.0
TLS2_k127_2138476_2 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 335.0
TLS2_k127_2138476_3 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000005489 159.0
TLS2_k127_2138476_4 Transcriptional regulator PadR-like family - - - 0.0000000000000000399 85.0
TLS2_k127_2138476_5 ABC-type antimicrobial peptide transport system, permease component - - - 0.00004934 48.0
TLS2_k127_2361904_0 glutamate catabolic process to 2-oxoglutarate K15371 - 1.4.1.2 0.0 1127.0
TLS2_k127_2361904_1 TIGRFAM type VI secretion ATPase, ClpV1 family K11907 - - 0.0 1015.0
TLS2_k127_2361904_10 protein conserved in bacteria K11904 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 344.0
TLS2_k127_2361904_11 Histidine-specific methyltransferase, SAM-dependent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 325.0
TLS2_k127_2361904_12 type VI secretion protein, VC_A0111 family K11895 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 328.0
TLS2_k127_2361904_13 type VI secretion protein K11900,K11901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 319.0
TLS2_k127_2361904_14 Uncharacterized protein conserved in bacteria (DUF2169) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 305.0
TLS2_k127_2361904_15 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 306.0
TLS2_k127_2361904_16 ImpE protein K11898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002261 283.0
TLS2_k127_2361904_17 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000003549 254.0
TLS2_k127_2361904_18 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001661 251.0
TLS2_k127_2361904_19 Type VI secretion system, VipA, VC_A0107 or Hcp2 K11901 - - 0.000000000000000000000000000000000000000000000000000000000000004329 222.0
TLS2_k127_2361904_2 Type VI secretion protein, EvpB/VC_A0108, tail sheath K11900 - - 1.194e-234 734.0
TLS2_k127_2361904_20 Type VI secretion system effector, Hcp K11903 - - 0.00000000000000000000000000000000000000000000000000000000000004722 218.0
TLS2_k127_2361904_21 synthase K00647 - 2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000001248 230.0
TLS2_k127_2361904_22 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000002582 224.0
TLS2_k127_2361904_23 Domain of unknown function (DUF4150) - - - 0.00000000000000000000000000000000000000000000000000000008334 198.0
TLS2_k127_2361904_24 PFAM Type IV VI secretion system, DotU K11892 - - 0.000000000000000000000000000000000000000000000013 179.0
TLS2_k127_2361904_25 - - - - 0.0000000000000000000000000000000000000000000008835 178.0
TLS2_k127_2361904_26 - - - - 0.0000000000000000000000000000000000000000003971 168.0
TLS2_k127_2361904_28 YCII-related domain K09780 - - 0.00000000000000000000000000000000000002712 146.0
TLS2_k127_2361904_29 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000000000000008359 146.0
TLS2_k127_2361904_3 Type VI secretion system, TssF K11896 - - 5.74e-197 633.0
TLS2_k127_2361904_30 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000003915 148.0
TLS2_k127_2361904_31 - - - - 0.000000000000000000000000000000004123 143.0
TLS2_k127_2361904_32 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000007998 135.0
TLS2_k127_2361904_33 - - - - 0.0000000000000000000000000006654 128.0
TLS2_k127_2361904_34 TIGRFAM Type VI secretion system, lysozyme-related K11897 - - 0.00000000000000000000000001243 117.0
TLS2_k127_2361904_36 thiolester hydrolase activity K06889 - - 0.00000000000000000001241 106.0
TLS2_k127_2361904_39 - - - - 0.000000000000001017 84.0
TLS2_k127_2361904_4 Gp5 C-terminal repeat (3 copies) K11904 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 602.0
TLS2_k127_2361904_40 type VI secretion protein K11900 - - 0.00000000000003626 76.0
TLS2_k127_2361904_41 - - - - 0.0000000000002937 80.0
TLS2_k127_2361904_43 - - - - 0.000000005269 64.0
TLS2_k127_2361904_44 - - - - 0.0000001026 64.0
TLS2_k127_2361904_45 NHL repeat - - - 0.0001422 53.0
TLS2_k127_2361904_5 ImcF-related N-terminal domain K11891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 625.0
TLS2_k127_2361904_6 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 546.0
TLS2_k127_2361904_7 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 522.0
TLS2_k127_2361904_8 ImpA, N-terminal, type VI secretion system K11902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009045 480.0
TLS2_k127_2361904_9 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 387.0
TLS2_k127_2418438_0 Amidohydrolase family - - - 0.0 1088.0
TLS2_k127_2418438_1 Belongs to the AAA ATPase family K13525 - - 2.634e-304 960.0
TLS2_k127_2418438_10 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000003046 242.0
TLS2_k127_2418438_11 Glycine zipper - - - 0.00000000000000000000000000000000000000000000000000000000000000000003064 243.0
TLS2_k127_2418438_12 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000001352 234.0
TLS2_k127_2418438_13 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000624 234.0
TLS2_k127_2418438_14 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000001313 190.0
TLS2_k127_2418438_15 PFAM AIG2 family protein - - - 0.00005332 52.0
TLS2_k127_2418438_2 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 619.0
TLS2_k127_2418438_3 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 592.0
TLS2_k127_2418438_4 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 536.0
TLS2_k127_2418438_5 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 298.0
TLS2_k127_2418438_6 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003855 289.0
TLS2_k127_2418438_7 Domain of unknown function (DUF4105) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002403 273.0
TLS2_k127_2418438_8 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005134 257.0
TLS2_k127_2418438_9 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000058 243.0
TLS2_k127_245839_0 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 0.0 1975.0
TLS2_k127_245839_1 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 4.646e-233 738.0
TLS2_k127_245839_10 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 419.0
TLS2_k127_245839_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 396.0
TLS2_k127_245839_12 cAMP biosynthetic process K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008826 417.0
TLS2_k127_245839_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 363.0
TLS2_k127_245839_14 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 350.0
TLS2_k127_245839_15 photoreceptor activity K14986 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 337.0
TLS2_k127_245839_16 Polyprenyl synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009095 325.0
TLS2_k127_245839_17 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 317.0
TLS2_k127_245839_18 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 336.0
TLS2_k127_245839_19 phosphorelay sensor kinase activity K07711,K14980,K18143 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 322.0
TLS2_k127_245839_2 Tetratricopeptide repeat K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007503 540.0
TLS2_k127_245839_20 electron transfer activity K03616 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008555 305.0
TLS2_k127_245839_21 gluconolactonase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000572 272.0
TLS2_k127_245839_22 Part of a membrane complex involved in electron transport K03617 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001801 251.0
TLS2_k127_245839_23 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004059 260.0
TLS2_k127_245839_24 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000000000000000000000000000002993 240.0
TLS2_k127_245839_25 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000009303 216.0
TLS2_k127_245839_26 - - - - 0.000000000000000000000000000000000000000000000000000000006479 215.0
TLS2_k127_245839_27 metal cluster binding - - - 0.0000000000000000000000000000000000000000000000000000007349 202.0
TLS2_k127_245839_28 polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000001393 209.0
TLS2_k127_245839_29 ECF sigma factor - - - 0.00000000000000000000000000000000000000000002258 169.0
TLS2_k127_245839_3 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 520.0
TLS2_k127_245839_30 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000003873 173.0
TLS2_k127_245839_31 - - - - 0.0000000000000000000000000000000000000000003818 165.0
TLS2_k127_245839_32 - - - - 0.000000000000000000000000000000000000000001606 164.0
TLS2_k127_245839_33 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000001242 171.0
TLS2_k127_245839_34 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000005728 156.0
TLS2_k127_245839_35 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000005553 142.0
TLS2_k127_245839_36 Parallel beta-helix repeats - - - 0.0000000000000000000000000000000000042 158.0
TLS2_k127_245839_37 Part of a membrane complex involved in electron transport - - - 0.000000000000000000000000000001565 139.0
TLS2_k127_245839_38 Adenylate cyclase - - - 0.000000000000000000000000009801 128.0
TLS2_k127_245839_39 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000002372 107.0
TLS2_k127_245839_4 COGs COG5616 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 526.0
TLS2_k127_245839_40 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000005833 103.0
TLS2_k127_245839_41 - - - - 0.000000000000000002261 89.0
TLS2_k127_245839_43 Transposase DDE domain - - - 0.00000000000000483 76.0
TLS2_k127_245839_45 rho-dependent transcription termination K19000 - - 0.0000000000006576 81.0
TLS2_k127_245839_46 Cytochrome c554 and c-prime - - - 0.0000000001216 64.0
TLS2_k127_245839_47 PD-(D/E)XK nuclease superfamily - - - 0.000000002929 60.0
TLS2_k127_245839_48 - - - - 0.000000003262 68.0
TLS2_k127_245839_5 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 504.0
TLS2_k127_245839_50 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.00000004219 60.0
TLS2_k127_245839_52 heme oxygenase (decyclizing) activity K07145,K21481 - 1.14.99.48,1.14.99.57 0.00001248 53.0
TLS2_k127_245839_53 - - - - 0.00002436 52.0
TLS2_k127_245839_6 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 456.0
TLS2_k127_245839_7 Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 434.0
TLS2_k127_245839_8 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 449.0
TLS2_k127_245839_9 Magnesium chelatase, subunit ChlI - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 417.0
TLS2_k127_2465703_0 PFAM deoxyribose-phosphate aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008226 547.0
TLS2_k127_2465703_1 Arginosuccinate synthase K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 525.0
TLS2_k127_2465703_10 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002672 265.0
TLS2_k127_2465703_11 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K00851,K00852,K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 0.000000000000000000000000000000000000000000000000000000000008089 215.0
TLS2_k127_2465703_12 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000006225 162.0
TLS2_k127_2465703_13 Regulates arginine biosynthesis genes K03402 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006355,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901605,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000004634 125.0
TLS2_k127_2465703_14 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.000000000000000000000000004215 117.0
TLS2_k127_2465703_15 PAS domain - - - 0.000000000000000989 89.0
TLS2_k127_2465703_16 Sodium/hydrogen exchanger family - - - 0.0000000000000166 83.0
TLS2_k127_2465703_17 - - - - 0.0007727 50.0
TLS2_k127_2465703_2 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009743 487.0
TLS2_k127_2465703_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 414.0
TLS2_k127_2465703_4 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 404.0
TLS2_k127_2465703_5 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 369.0
TLS2_k127_2465703_6 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800,K00945 - 2.5.1.19,2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 365.0
TLS2_k127_2465703_7 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 364.0
TLS2_k127_2465703_8 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 364.0
TLS2_k127_2465703_9 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 302.0
TLS2_k127_2480078_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 2.251e-265 835.0
TLS2_k127_2480078_1 Aldehyde dehydrogenase family K22187 - - 2.901e-246 767.0
TLS2_k127_2480078_10 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 482.0
TLS2_k127_2480078_11 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 428.0
TLS2_k127_2480078_12 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006473 421.0
TLS2_k127_2480078_13 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 421.0
TLS2_k127_2480078_14 Beta-eliminating lyase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 347.0
TLS2_k127_2480078_15 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 349.0
TLS2_k127_2480078_16 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 345.0
TLS2_k127_2480078_17 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 335.0
TLS2_k127_2480078_18 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 334.0
TLS2_k127_2480078_19 Ribosomal protein S2 K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 327.0
TLS2_k127_2480078_2 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.689e-231 742.0
TLS2_k127_2480078_20 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 319.0
TLS2_k127_2480078_21 Sugar nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 326.0
TLS2_k127_2480078_22 Nucleotidyl transferase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006757 319.0
TLS2_k127_2480078_23 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007562 321.0
TLS2_k127_2480078_24 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 329.0
TLS2_k127_2480078_25 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 300.0
TLS2_k127_2480078_26 Cysteine desulfurase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 300.0
TLS2_k127_2480078_27 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001086 286.0
TLS2_k127_2480078_28 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005628 284.0
TLS2_k127_2480078_29 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007884 274.0
TLS2_k127_2480078_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.593e-210 686.0
TLS2_k127_2480078_30 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000001373 256.0
TLS2_k127_2480078_31 PFAM PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009508 259.0
TLS2_k127_2480078_32 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008935 257.0
TLS2_k127_2480078_33 GlcNAc-PI de-N-acetylase K01463 - - 0.000000000000000000000000000000000000000000000000000000000000000002403 234.0
TLS2_k127_2480078_34 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000002777 233.0
TLS2_k127_2480078_35 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001552 232.0
TLS2_k127_2480078_36 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000009909 220.0
TLS2_k127_2480078_37 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000005611 220.0
TLS2_k127_2480078_38 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000811 211.0
TLS2_k127_2480078_39 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000007348 204.0
TLS2_k127_2480078_4 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 609.0
TLS2_k127_2480078_40 creatininase K01470,K22232 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000002249 202.0
TLS2_k127_2480078_41 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000003943 170.0
TLS2_k127_2480078_42 histidine kinase DNA gyrase B - - - 0.0000000000000000000000000000000000000000004845 174.0
TLS2_k127_2480078_43 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000002027 166.0
TLS2_k127_2480078_44 Ribosomal protein S9/S16 K02996 - - 0.00000000000000000000000000000000000000002678 156.0
TLS2_k127_2480078_45 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.000000000000000000000000000000000004371 146.0
TLS2_k127_2480078_46 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.000000000000000000000000000000001254 145.0
TLS2_k127_2480078_47 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000001723 132.0
TLS2_k127_2480078_48 cheY-homologous receiver domain - - - 0.00000000000000000000000000000005876 132.0
TLS2_k127_2480078_49 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000009749 123.0
TLS2_k127_2480078_5 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 563.0
TLS2_k127_2480078_51 Ribosome-binding factor A K02834 - - 0.0000000000000000000000000008296 120.0
TLS2_k127_2480078_53 SMART Chromosomal replication initiator DnaA domain - - - 0.0000000000000000001751 101.0
TLS2_k127_2480078_54 - - - - 0.00000000000000009397 91.0
TLS2_k127_2480078_55 Protein of unknown function (DUF503) K09764 - - 0.000000000000006999 78.0
TLS2_k127_2480078_56 ribosomal protein - - - 0.00000000000002141 79.0
TLS2_k127_2480078_57 rod shape-determining protein MreC K03570 - - 0.0000000000006545 75.0
TLS2_k127_2480078_59 OsmC-like protein - - - 0.00000817 51.0
TLS2_k127_2480078_6 Hsp70 protein K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005813 540.0
TLS2_k127_2480078_60 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0004795 50.0
TLS2_k127_2480078_7 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 542.0
TLS2_k127_2480078_8 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 543.0
TLS2_k127_2480078_9 Magnesium chelatase, subunit ChlI K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 533.0
TLS2_k127_259408_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1249.0
TLS2_k127_259408_1 carbohydrate transport K02027 - - 0.0 1143.0
TLS2_k127_259408_10 Tetratricopeptide repeat K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006555 576.0
TLS2_k127_259408_11 PglZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 548.0
TLS2_k127_259408_12 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005444 529.0
TLS2_k127_259408_13 transferase activity, transferring glycosyl groups K20885 - 2.4.1.339,2.4.1.340 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 502.0
TLS2_k127_259408_14 ABC transporter K10111,K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 476.0
TLS2_k127_259408_15 transferase activity, transferring glycosyl groups K20885 - 2.4.1.339,2.4.1.340 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 476.0
TLS2_k127_259408_16 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006363 466.0
TLS2_k127_259408_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 455.0
TLS2_k127_259408_18 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 470.0
TLS2_k127_259408_19 ABC transporter K02021,K06147,K11085 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 456.0
TLS2_k127_259408_2 amine dehydrogenase activity K17285 - - 1.188e-242 760.0
TLS2_k127_259408_20 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008213 420.0
TLS2_k127_259408_21 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005973 409.0
TLS2_k127_259408_22 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 404.0
TLS2_k127_259408_23 Mitochondrial degradasome RNA helicase subunit C terminal K17675 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 392.0
TLS2_k127_259408_24 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843,K02849,K12982 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 374.0
TLS2_k127_259408_25 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 368.0
TLS2_k127_259408_26 Glycosyltransferase family 9 (heptosyltransferase) K12982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 342.0
TLS2_k127_259408_27 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 319.0
TLS2_k127_259408_28 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 300.0
TLS2_k127_259408_29 Binding-protein-dependent transport system inner membrane component K02025,K17322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 298.0
TLS2_k127_259408_3 Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00122 - 1.17.1.9 3.627e-232 732.0
TLS2_k127_259408_30 M20 M25 M40 family peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 294.0
TLS2_k127_259408_31 hemolysin III K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002358 284.0
TLS2_k127_259408_32 Psort location CytoplasmicMembrane, score 10.00 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005927 280.0
TLS2_k127_259408_33 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000171 275.0
TLS2_k127_259408_34 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001739 262.0
TLS2_k127_259408_35 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004097 260.0
TLS2_k127_259408_36 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000001276 248.0
TLS2_k127_259408_37 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002437 233.0
TLS2_k127_259408_38 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000004719 244.0
TLS2_k127_259408_39 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000000000000000000000000006628 228.0
TLS2_k127_259408_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 2.579e-227 719.0
TLS2_k127_259408_40 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000001368 218.0
TLS2_k127_259408_41 - - - - 0.000000000000000000000000000000000000000000000000000000000000821 216.0
TLS2_k127_259408_42 PFAM GCN5-related N-acetyltransferase K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000001713 213.0
TLS2_k127_259408_43 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000504 214.0
TLS2_k127_259408_44 DinB family - - - 0.00000000000000000000000000000000000000000000000000000006073 200.0
TLS2_k127_259408_45 Lytic transglycosylase catalytic K08307 - - 0.0000000000000000000000000000000000000000000000000000006709 207.0
TLS2_k127_259408_46 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000007826 194.0
TLS2_k127_259408_47 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01190 - 3.2.1.23 0.00000000000000000000000000000000000000000000000000002625 203.0
TLS2_k127_259408_48 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000000000000001205 190.0
TLS2_k127_259408_49 PFAM peptidase M6, immune inhibitor A - - - 0.00000000000000000000000000000000000000000000000003772 204.0
TLS2_k127_259408_5 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.986e-201 642.0
TLS2_k127_259408_50 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000002022 190.0
TLS2_k127_259408_51 CHRD domain - - - 0.0000000000000000000000000000000000000000000000006152 183.0
TLS2_k127_259408_52 Glycosyl transferase family 2 K08301 - - 0.00000000000000000000000000000000000000000000002441 190.0
TLS2_k127_259408_53 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000001026 180.0
TLS2_k127_259408_54 Arginase family - - - 0.0000000000000000000000000000000000000000000008651 177.0
TLS2_k127_259408_55 formate dehydrogenase - - - 0.00000000000000000000000000000000000000000003106 177.0
TLS2_k127_259408_56 hydroperoxide reductase activity - - - 0.0000000000000000000000000000000000000000002782 160.0
TLS2_k127_259408_57 PFAM GCN5-related N-acetyltransferase K06976 - - 0.000000000000000000000000000000000000000001607 169.0
TLS2_k127_259408_58 PAS fold - - - 0.000000000000000000000000000000000000000002936 162.0
TLS2_k127_259408_59 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000004509 154.0
TLS2_k127_259408_6 PhoQ Sensor - - - 1.325e-200 659.0
TLS2_k127_259408_60 Putative thioesterase (yiiD_Cterm) - - - 0.000000000000000000000000000000000009163 142.0
TLS2_k127_259408_61 - - - - 0.00000000000000000000000000000000376 137.0
TLS2_k127_259408_62 Lytic transglycosylase catalytic - - - 0.00000000000000000000000000000008956 130.0
TLS2_k127_259408_63 hydroperoxide reductase activity - - - 0.0000000000000000000000000000001566 126.0
TLS2_k127_259408_64 OsmC-like protein - - - 0.0000000000000000000000000000002201 128.0
TLS2_k127_259408_65 Histidine kinase - - - 0.0000000000000000000000000000009944 139.0
TLS2_k127_259408_67 PFAM aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.0000000000000000000000000085 121.0
TLS2_k127_259408_68 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000009301 116.0
TLS2_k127_259408_69 Immunoglobulin-like domain of bacterial spore germination - - - 0.000000000000000000000002626 113.0
TLS2_k127_259408_7 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 572.0
TLS2_k127_259408_70 Phage integrase, N-terminal SAM-like domain - - - 0.00000000000000000001824 101.0
TLS2_k127_259408_71 - - - - 0.0000000000000000002943 98.0
TLS2_k127_259408_72 transporter K12942 - - 0.0000000000000000005422 86.0
TLS2_k127_259408_73 PFAM regulatory protein GntR HTH - - - 0.000000000000000003374 93.0
TLS2_k127_259408_74 - - - - 0.0000000000000001637 82.0
TLS2_k127_259408_75 Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position K11211 - 2.7.1.166 0.0000000000000002285 90.0
TLS2_k127_259408_76 - - - - 0.00000000000003519 74.0
TLS2_k127_259408_77 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000000000003333 74.0
TLS2_k127_259408_78 Carboxypeptidase regulatory-like domain K02014 - - 0.0000000000007269 78.0
TLS2_k127_259408_79 DinB family - - - 0.0000000000009271 79.0
TLS2_k127_259408_8 KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 576.0
TLS2_k127_259408_80 - - - - 0.0000001626 53.0
TLS2_k127_259408_81 Capsule assembly protein Wzi - - - 0.0000009208 61.0
TLS2_k127_259408_82 TIGRFAM cytochrome C family protein - - - 0.0000009454 61.0
TLS2_k127_259408_84 - - - - 0.0004424 45.0
TLS2_k127_259408_85 - - - - 0.0009272 47.0
TLS2_k127_259408_86 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0009656 49.0
TLS2_k127_259408_9 ABC transporter K15738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 573.0
TLS2_k127_2828821_0 - - - - 3.633e-244 766.0
TLS2_k127_2828821_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 473.0
TLS2_k127_2828821_10 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000000000001022 83.0
TLS2_k127_2828821_11 - - - - 0.000000000001316 79.0
TLS2_k127_2828821_12 PDZ DHR GLGF domain protein - - - 0.0000005002 62.0
TLS2_k127_2828821_13 - - - - 0.0007228 51.0
TLS2_k127_2828821_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000002116 250.0
TLS2_k127_2828821_3 translation initiation factor activity K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000004796 230.0
TLS2_k127_2828821_4 Bacterial transcriptional repressor C-terminal K16137 - - 0.0000000000000000000000000000000000000000000000000000000000008937 222.0
TLS2_k127_2828821_5 YCII-related domain - - - 0.000000000000000000000000000000000000000000006226 168.0
TLS2_k127_2828821_6 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000003768 126.0
TLS2_k127_2828821_7 ketosteroid isomerase - - - 0.000000000000000000009884 100.0
TLS2_k127_2828821_8 - - - - 0.000000000000001628 87.0
TLS2_k127_2828821_9 glyoxalase III activity - - - 0.000000000000002285 85.0
TLS2_k127_2848017_0 Domain related to MnhB subunit of Na+/H+ antiporter K00341,K05559 - 1.6.5.3 7e-323 1013.0
TLS2_k127_2848017_1 Carbohydrate family 9 binding domain-like - - - 2.937e-261 833.0
TLS2_k127_2848017_10 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 611.0
TLS2_k127_2848017_100 Putative adhesin - - - 0.00000000000000000008102 101.0
TLS2_k127_2848017_101 - - - - 0.000000000000001083 85.0
TLS2_k127_2848017_103 pathogenesis - - - 0.00000000000000109 85.0
TLS2_k127_2848017_105 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000002535 59.0
TLS2_k127_2848017_106 usher protein - - - 0.00000007339 66.0
TLS2_k127_2848017_107 - - - - 0.00001335 55.0
TLS2_k127_2848017_11 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006771 605.0
TLS2_k127_2848017_12 mannose-ethanolamine phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 615.0
TLS2_k127_2848017_13 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 599.0
TLS2_k127_2848017_14 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 570.0
TLS2_k127_2848017_15 Peptidase, M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 520.0
TLS2_k127_2848017_16 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 502.0
TLS2_k127_2848017_17 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005348 519.0
TLS2_k127_2848017_18 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 508.0
TLS2_k127_2848017_19 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 499.0
TLS2_k127_2848017_2 lysine biosynthetic process via aminoadipic acid - - - 7.353e-232 746.0
TLS2_k127_2848017_20 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005186 505.0
TLS2_k127_2848017_21 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006037 490.0
TLS2_k127_2848017_22 PFAM NADH Ubiquinone plastoquinone K05561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 492.0
TLS2_k127_2848017_23 Belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 482.0
TLS2_k127_2848017_24 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007216 470.0
TLS2_k127_2848017_25 Peptidase, M16 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007471 472.0
TLS2_k127_2848017_26 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 483.0
TLS2_k127_2848017_27 Rieske (2fe-2S) K00499 - 1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008551 456.0
TLS2_k127_2848017_28 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 451.0
TLS2_k127_2848017_29 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 450.0
TLS2_k127_2848017_3 Dehydrogenase K00117 - 1.1.5.2 2.384e-229 728.0
TLS2_k127_2848017_30 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 430.0
TLS2_k127_2848017_31 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 409.0
TLS2_k127_2848017_32 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 398.0
TLS2_k127_2848017_33 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 381.0
TLS2_k127_2848017_34 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 386.0
TLS2_k127_2848017_35 Domain present in phytochromes and cGMP-specific phosphodiesterases. K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 396.0
TLS2_k127_2848017_36 -O-antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 377.0
TLS2_k127_2848017_37 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 359.0
TLS2_k127_2848017_38 neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 357.0
TLS2_k127_2848017_39 PFAM peptidase T2 asparaginase 2 K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 382.0
TLS2_k127_2848017_4 Ion transport 2 domain protein - - - 2.748e-227 721.0
TLS2_k127_2848017_40 M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 374.0
TLS2_k127_2848017_41 Belongs to the DapA family K21062 - 3.5.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 351.0
TLS2_k127_2848017_42 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 340.0
TLS2_k127_2848017_43 FAD dependent oxidoreductase K21061 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 335.0
TLS2_k127_2848017_44 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 331.0
TLS2_k127_2848017_45 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 319.0
TLS2_k127_2848017_46 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 306.0
TLS2_k127_2848017_47 Belongs to the proline racemase family K12658 GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855,GO:0036361,GO:0047580,GO:0047661 5.1.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 304.0
TLS2_k127_2848017_48 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 299.0
TLS2_k127_2848017_49 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 291.0
TLS2_k127_2848017_5 Domain of unknown function (DUF5118) - - - 4.647e-221 718.0
TLS2_k127_2848017_50 response regulator K07693 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001711 276.0
TLS2_k127_2848017_51 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000157 266.0
TLS2_k127_2848017_52 Fe-S protein K07140 GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0050896,GO:0098754 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003871 261.0
TLS2_k127_2848017_53 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003508 258.0
TLS2_k127_2848017_54 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000001887 254.0
TLS2_k127_2848017_55 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003707 254.0
TLS2_k127_2848017_56 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005379 260.0
TLS2_k127_2848017_57 Histidine kinase K07778 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000003311 251.0
TLS2_k127_2848017_58 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000478 239.0
TLS2_k127_2848017_59 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000002291 233.0
TLS2_k127_2848017_6 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 1.159e-205 651.0
TLS2_k127_2848017_60 CDP-alcohol phosphatidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000004306 229.0
TLS2_k127_2848017_61 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000003335 229.0
TLS2_k127_2848017_62 - - - - 0.000000000000000000000000000000000000000000000000000000000000003406 222.0
TLS2_k127_2848017_63 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000004394 243.0
TLS2_k127_2848017_64 - - - - 0.00000000000000000000000000000000000000000000000000000000000002004 221.0
TLS2_k127_2848017_65 dolichyl monophosphate biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000001063 220.0
TLS2_k127_2848017_66 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000008218 224.0
TLS2_k127_2848017_67 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000004713 207.0
TLS2_k127_2848017_68 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000005166 211.0
TLS2_k127_2848017_69 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000001674 211.0
TLS2_k127_2848017_7 Amidohydrolase family - - - 1.203e-203 653.0
TLS2_k127_2848017_70 cytochrome c nitrite reductase K15876 - - 0.0000000000000000000000000000000000000000000000000000001005 199.0
TLS2_k127_2848017_71 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000001557 198.0
TLS2_k127_2848017_72 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000000000000004514 203.0
TLS2_k127_2848017_73 ErfK ybiS ycfS ynhG family protein - - - 0.00000000000000000000000000000000000000000000000000009478 204.0
TLS2_k127_2848017_74 Protein of unknown function (DUF1648) - - - 0.000000000000000000000000000000000000000000000003759 184.0
TLS2_k127_2848017_75 homoserine kinase activity K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.000000000000000000000000000000000000000001289 172.0
TLS2_k127_2848017_76 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000001483 160.0
TLS2_k127_2848017_77 YjbR - - - 0.000000000000000000000000000000000000000001556 171.0
TLS2_k127_2848017_78 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000051 168.0
TLS2_k127_2848017_79 Multisubunit Na H antiporter MnhE subunit K05562,K05569 - - 0.000000000000000000000000000000000000000007174 158.0
TLS2_k127_2848017_8 nuclear chromosome segregation - - - 3.444e-199 664.0
TLS2_k127_2848017_81 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000008204 154.0
TLS2_k127_2848017_82 - - - - 0.00000000000000000000000000000000000002794 155.0
TLS2_k127_2848017_83 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.00000000000000000000000000000000000042 150.0
TLS2_k127_2848017_84 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05560 - - 0.00000000000000000000000000000000001882 138.0
TLS2_k127_2848017_85 - - - - 0.0000000000000000000000000000000004027 133.0
TLS2_k127_2848017_86 Na+/H+ antiporter subunit K05564 - - 0.000000000000000000000000000000005563 135.0
TLS2_k127_2848017_87 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000007255 136.0
TLS2_k127_2848017_88 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000002095 139.0
TLS2_k127_2848017_89 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000002692 120.0
TLS2_k127_2848017_9 Putative glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 628.0
TLS2_k127_2848017_90 PFAM Mo-dependent nitrogenase - - - 0.0000000000000000000000000007499 123.0
TLS2_k127_2848017_91 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000004381 123.0
TLS2_k127_2848017_92 Multiple resistance and pH regulation protein F K05563 - - 0.000000000000000000000000006754 121.0
TLS2_k127_2848017_93 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000001078 116.0
TLS2_k127_2848017_94 Chaperone - - - 0.0000000000000000000000002456 116.0
TLS2_k127_2848017_96 cheY-homologous receiver domain - - - 0.00000000000000000000006442 103.0
TLS2_k127_2848017_97 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000003454 98.0
TLS2_k127_2848017_99 Domain of unknown function (DUF4153) - - - 0.00000000000000000002617 106.0
TLS2_k127_2873694_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 2.539e-256 801.0
TLS2_k127_2873694_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 4.932e-243 769.0
TLS2_k127_2873694_2 acetyl-CoA carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000004871 116.0
TLS2_k127_2873694_3 LppC putative lipoprotein - - - 0.000000000009424 78.0
TLS2_k127_2891258_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 295.0
TLS2_k127_2891258_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006126 266.0
TLS2_k127_2894418_0 GMC oxidoreductase - - - 1.344e-279 871.0
TLS2_k127_2894418_1 PFAM nucleoside H symporter - - - 2.837e-196 619.0
TLS2_k127_2894418_10 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 295.0
TLS2_k127_2894418_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004721 267.0
TLS2_k127_2894418_12 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001593 255.0
TLS2_k127_2894418_13 Dienelactone hydrolase family K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000003689 241.0
TLS2_k127_2894418_14 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000007446 196.0
TLS2_k127_2894418_15 Gluconate 2-dehydrogenase subunit 3 - - - 0.00000000000000000000000000000000000000000000000007127 185.0
TLS2_k127_2894418_16 helix_turn_helix multiple antibiotic resistance protein K15973 - - 0.000000000000000000000000000000000000000000834 161.0
TLS2_k127_2894418_17 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000001284 152.0
TLS2_k127_2894418_18 domain protein K07004,K09955,K16915,K20276 - - 0.00000000000000000000000000000000001011 160.0
TLS2_k127_2894418_19 Domain of unknown function (DUF4112) - - - 0.0000000000000000000000000000000003712 139.0
TLS2_k127_2894418_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 5.734e-194 612.0
TLS2_k127_2894418_20 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000004682 146.0
TLS2_k127_2894418_21 domain, Protein - - - 0.000000000000000000000000003007 132.0
TLS2_k127_2894418_23 Rieske [2Fe-2S] domain - - - 0.0000000000000000000004757 112.0
TLS2_k127_2894418_24 Forkhead associated domain - - - 0.00000000000000000007613 97.0
TLS2_k127_2894418_25 ErfK ybiS ycfS ynhG family protein K19234 - - 0.0000000000000000001372 94.0
TLS2_k127_2894418_26 Bacterial Ig-like domain (group 1) K13735 - - 0.000000000000000000171 106.0
TLS2_k127_2894418_27 ErfK YbiS YcfS YnhG family protein - - - 0.000006187 53.0
TLS2_k127_2894418_28 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00002796 54.0
TLS2_k127_2894418_29 cellulase activity - - - 0.0004693 53.0
TLS2_k127_2894418_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 556.0
TLS2_k127_2894418_30 Phage late control gene D protein (GPD) K11904 - - 0.0007844 42.0
TLS2_k127_2894418_4 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000881 543.0
TLS2_k127_2894418_5 guanyl-nucleotide exchange factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 512.0
TLS2_k127_2894418_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 416.0
TLS2_k127_2894418_7 Thioesterase-like superfamily K10805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004323 348.0
TLS2_k127_2894418_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000061 336.0
TLS2_k127_2894418_9 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 338.0
TLS2_k127_2912829_0 efflux transmembrane transporter activity - - - 6.53e-286 904.0
TLS2_k127_2912829_1 PFAM Bile acid sodium symporter K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005572 588.0
TLS2_k127_2912829_10 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003834 270.0
TLS2_k127_2912829_11 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000000000000000005421 236.0
TLS2_k127_2912829_12 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000004129 216.0
TLS2_k127_2912829_13 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000005115 205.0
TLS2_k127_2912829_14 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000000002786 174.0
TLS2_k127_2912829_15 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000002961 183.0
TLS2_k127_2912829_16 Sigma-70, region 4 K02405 - - 0.0000000000000000000000000000000000000000003559 169.0
TLS2_k127_2912829_17 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000001103 160.0
TLS2_k127_2912829_18 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000212 161.0
TLS2_k127_2912829_19 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00000000000000000000000000000000000001397 150.0
TLS2_k127_2912829_2 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 563.0
TLS2_k127_2912829_20 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000001341 143.0
TLS2_k127_2912829_21 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000003449 140.0
TLS2_k127_2912829_22 helix_turn_helix, arabinose operon control protein K07506 - - 0.00000000000000000000000000006589 127.0
TLS2_k127_2912829_23 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000007695 121.0
TLS2_k127_2912829_24 helix_turn_helix, Arsenical Resistance Operon Repressor K03892,K21903 - - 0.00000000000000000000000003642 111.0
TLS2_k127_2912829_25 - - - - 0.000000000000000000002513 100.0
TLS2_k127_2912829_26 Helix-turn-helix domain K07729 - - 0.00000000000000000005136 94.0
TLS2_k127_2912829_27 cellulase activity - - - 0.00000000000000002737 97.0
TLS2_k127_2912829_29 cheY-homologous receiver domain K03413 - - 0.0000000009855 60.0
TLS2_k127_2912829_3 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 537.0
TLS2_k127_2912829_30 - - - - 0.000000009632 63.0
TLS2_k127_2912829_32 - - - - 0.000001281 62.0
TLS2_k127_2912829_34 FlgN protein - - - 0.0001903 52.0
TLS2_k127_2912829_4 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 534.0
TLS2_k127_2912829_5 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 540.0
TLS2_k127_2912829_6 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 533.0
TLS2_k127_2912829_7 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 529.0
TLS2_k127_2912829_8 BAAT / Acyl-CoA thioester hydrolase C terminal K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 428.0
TLS2_k127_2912829_9 phosphoprotein phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 374.0
TLS2_k127_2913310_0 TonB dependent receptor - - - 1.235e-227 734.0
TLS2_k127_2913310_1 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005883 501.0
TLS2_k127_2913310_10 PAP2 superfamily K19302 - 3.6.1.27 0.000000000000000000002404 98.0
TLS2_k127_2913310_11 Phosphate-selective porin O and P K07221 - - 0.0000005089 61.0
TLS2_k127_2913310_2 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 437.0
TLS2_k127_2913310_3 PFAM extracellular solute-binding protein family 1 K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 369.0
TLS2_k127_2913310_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006008 375.0
TLS2_k127_2913310_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 360.0
TLS2_k127_2913310_6 Phosphate transport system permease protein PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 331.0
TLS2_k127_2913310_7 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005053 274.0
TLS2_k127_2913310_8 HAMP domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001996 276.0
TLS2_k127_2913310_9 - - - - 0.000000000000000000000003653 115.0
TLS2_k127_3031740_0 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 345.0
TLS2_k127_3055643_0 peptidyl-tyrosine sulfation - - - 0.0 1306.0
TLS2_k127_3055643_1 electron transport chain K00347,K03614 - 1.6.5.8 1.544e-296 924.0
TLS2_k127_3055643_10 Lactonase, 7-bladed beta-propeller K07404 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 310.0
TLS2_k127_3055643_11 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 316.0
TLS2_k127_3055643_12 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) K01083 - 3.1.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005614 285.0
TLS2_k127_3055643_13 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008188 273.0
TLS2_k127_3055643_14 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003597 262.0
TLS2_k127_3055643_15 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000000000000000000000000002861 232.0
TLS2_k127_3055643_16 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000026 203.0
TLS2_k127_3055643_17 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000002911 186.0
TLS2_k127_3055643_18 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000005199 182.0
TLS2_k127_3055643_19 Amidohydrolase - - - 0.0000000000000000000000000000000000000000001909 178.0
TLS2_k127_3055643_2 Penicillin amidase - - - 4.339e-287 903.0
TLS2_k127_3055643_20 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000002127 157.0
TLS2_k127_3055643_21 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000005331 143.0
TLS2_k127_3055643_22 YjbR - - - 0.00000000000000000000000000000002697 134.0
TLS2_k127_3055643_23 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000000000004143 139.0
TLS2_k127_3055643_24 Patatin-like phospholipase - - - 0.00000000000000000000000000000009868 144.0
TLS2_k127_3055643_25 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000002443 102.0
TLS2_k127_3055643_26 - - - - 0.00000000000000000000744 100.0
TLS2_k127_3055643_27 - - - - 0.00000000000000000001517 94.0
TLS2_k127_3055643_28 CHAT domain - - - 0.00000000000000009649 95.0
TLS2_k127_3055643_29 Cadherin-like beta sandwich domain - - - 0.0000000000007106 80.0
TLS2_k127_3055643_3 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 1.163e-245 787.0
TLS2_k127_3055643_30 - - - - 0.000000000001429 75.0
TLS2_k127_3055643_31 - - - - 0.00001502 48.0
TLS2_k127_3055643_32 transcriptional regulator, LuxR family K08282 - 2.7.11.1 0.00002799 58.0
TLS2_k127_3055643_4 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 526.0
TLS2_k127_3055643_5 membrane organization - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 414.0
TLS2_k127_3055643_6 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 383.0
TLS2_k127_3055643_7 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 383.0
TLS2_k127_3055643_8 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 371.0
TLS2_k127_3055643_9 Conserved protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009262 312.0
TLS2_k127_307854_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1026.0
TLS2_k127_307854_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 4.206e-292 925.0
TLS2_k127_307854_10 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000003001 196.0
TLS2_k127_307854_11 Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000000000000000000161 205.0
TLS2_k127_307854_12 - - - - 0.000000000000000000000000000000000000000000000009779 181.0
TLS2_k127_307854_13 serine-type endopeptidase activity K09973 - - 0.0000000000000000000000000000000000000004457 162.0
TLS2_k127_307854_14 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000000000000000008161 148.0
TLS2_k127_307854_15 Two component signalling adaptor domain K03408 - - 0.00000000000000529 82.0
TLS2_k127_307854_2 Alpha-glucan phosphorylase K00688 - 2.4.1.1 2.195e-219 704.0
TLS2_k127_307854_3 Histidine kinase K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 522.0
TLS2_k127_307854_4 transmembrane signaling receptor activity K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009726 375.0
TLS2_k127_307854_5 Mechanosensitive ion channel K05802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005218 396.0
TLS2_k127_307854_6 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 318.0
TLS2_k127_307854_7 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005659 286.0
TLS2_k127_307854_8 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002849 244.0
TLS2_k127_307854_9 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.0000000000000000000000000000000000000000000000000000000000003804 228.0
TLS2_k127_3084621_0 DNA restriction-modification system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 420.0
TLS2_k127_3084621_1 helicase - - - 0.0000000000000000000000000000000000000000000000000000000002007 229.0
TLS2_k127_3084621_2 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000001852 173.0
TLS2_k127_3084621_3 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000002295 168.0
TLS2_k127_3097839_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 475.0
TLS2_k127_3097839_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000003068 182.0
TLS2_k127_3111574_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 552.0
TLS2_k127_3111574_1 Iron-storage protein K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000002737 186.0
TLS2_k127_3111574_2 Protein of unknown function (DUF664) - - - 0.000000000000001488 88.0
TLS2_k127_3111574_3 Protein kinase domain K12132 - 2.7.11.1 0.00000000001862 74.0
TLS2_k127_3170881_0 Uncharacterized protein family (UPF0051) K09014 - - 1.402e-222 698.0
TLS2_k127_3170881_1 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 554.0
TLS2_k127_3170881_10 4Fe-4S binding domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008989 379.0
TLS2_k127_3170881_11 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 356.0
TLS2_k127_3170881_12 Belongs to the serpin family K13963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 327.0
TLS2_k127_3170881_13 ATPases associated with a variety of cellular activities K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007124 316.0
TLS2_k127_3170881_14 PFAM Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005389 272.0
TLS2_k127_3170881_15 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000712 283.0
TLS2_k127_3170881_16 response to abiotic stimulus K06867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001193 269.0
TLS2_k127_3170881_17 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000003927 243.0
TLS2_k127_3170881_18 3-beta hydroxysteroid dehydrogenase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000558 236.0
TLS2_k127_3170881_19 TraB family K09973 - - 0.0000000000000000000000000000000000000000000000000000008271 205.0
TLS2_k127_3170881_2 Beta-eliminating lyase K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 522.0
TLS2_k127_3170881_20 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000009599 204.0
TLS2_k127_3170881_21 carboxylic acid catabolic process - - - 0.0000000000000000000000000000000000000000000000002268 188.0
TLS2_k127_3170881_22 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000005685 187.0
TLS2_k127_3170881_23 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.000000000000000000000000000000000000000000000001108 182.0
TLS2_k127_3170881_24 COG0822 NifU homolog involved in Fe-S cluster formation K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.000000000000000000000000000000000000000000000003789 176.0
TLS2_k127_3170881_25 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000001093 176.0
TLS2_k127_3170881_26 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000006095 185.0
TLS2_k127_3170881_27 4Fe-4S single cluster domain K07001 - - 0.0000000000000000000000000000000000000000000001116 183.0
TLS2_k127_3170881_28 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.000000000000000000000000000000000000000003743 169.0
TLS2_k127_3170881_29 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000628 156.0
TLS2_k127_3170881_3 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 518.0
TLS2_k127_3170881_30 Acid phosphatase homologues - - - 0.000000000000000000000000000000000003007 148.0
TLS2_k127_3170881_31 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000004306 143.0
TLS2_k127_3170881_32 FAD binding domain K11472 - - 0.000000000000000000000000000001707 139.0
TLS2_k127_3170881_33 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000001189 136.0
TLS2_k127_3170881_34 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000000006901 119.0
TLS2_k127_3170881_35 Sterol carrier protein domain - - - 0.0000000000000000000000006857 120.0
TLS2_k127_3170881_36 COGs COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase K05710 - - 0.0000000000000000000000989 103.0
TLS2_k127_3170881_37 Protein of unknown function (DUF1778) - - - 0.0000000000000002968 83.0
TLS2_k127_3170881_38 cheY-homologous receiver domain K11443 - - 0.0000000000000007543 83.0
TLS2_k127_3170881_4 PFAM UvrD REP helicase K03656,K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 522.0
TLS2_k127_3170881_5 Beta-eliminating lyase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 499.0
TLS2_k127_3170881_6 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 480.0
TLS2_k127_3170881_7 LytB protein K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 482.0
TLS2_k127_3170881_8 M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 427.0
TLS2_k127_3170881_9 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 380.0
TLS2_k127_3191240_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 4.988e-221 696.0
TLS2_k127_3191240_1 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 533.0
TLS2_k127_3191240_2 6-phospho-beta-galactosidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 455.0
TLS2_k127_3191240_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000009901 134.0
TLS2_k127_3191240_4 Vitamin K epoxide reductase family - - - 0.000000000000000000000000000008708 135.0
TLS2_k127_3191240_5 Virulence factor BrkB K07058 - - 0.000000000000004942 77.0
TLS2_k127_3506032_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000001038 158.0
TLS2_k127_3512351_0 Integrase core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 351.0
TLS2_k127_3512351_1 Bacterial dnaA protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 313.0
TLS2_k127_3586750_0 PD-(D/E)XK nuclease superfamily K01144,K07464,K16898 - 3.1.11.5,3.1.12.1,3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 473.0
TLS2_k127_3586750_1 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 323.0
TLS2_k127_3586750_2 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00015,K18916 - 1.1.1.26,1.20.1.1 0.0000000000000000000000000000000000000000000001681 175.0
TLS2_k127_3607300_0 - K13582,K13924,K15580 - 2.1.1.80,3.1.1.61 0.0 1861.0
TLS2_k127_3607300_1 ATPase involved in DNA repair K13924 - 2.1.1.80,3.1.1.61 0.0 1070.0
TLS2_k127_3607300_2 ribosome binding - - - 0.0 1048.0
TLS2_k127_3607300_3 Alkaline phosphatase - - - 1.45e-283 894.0
TLS2_k127_3607300_4 YCII-related domain - - - 0.000000000000000000000000000000000000000001076 165.0
TLS2_k127_3607300_5 - - - - 0.000000000000000000000000000001338 122.0
TLS2_k127_3657683_0 glutaminyl-tRNA K01886 - 6.1.1.18 2.011e-272 860.0
TLS2_k127_3657683_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 5.317e-199 629.0
TLS2_k127_3657683_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 489.0
TLS2_k127_3657683_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 462.0
TLS2_k127_3657683_4 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 320.0
TLS2_k127_3657683_5 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 321.0
TLS2_k127_3657683_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000001201 231.0
TLS2_k127_3657683_7 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000002366 207.0
TLS2_k127_3657683_8 Cupin 2, conserved barrel domain protein - - - 0.000000000000002624 81.0
TLS2_k127_3753062_0 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 374.0
TLS2_k127_3753062_1 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 350.0
TLS2_k127_3753062_2 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000009907 234.0
TLS2_k127_3753062_3 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000000000000000000003175 211.0
TLS2_k127_3753062_4 Alpha Beta K06889 - - 0.0000000000000000000000000000000000000000000000000007641 204.0
TLS2_k127_3753062_5 - - - - 0.000000000000000000000000000000000000000000000000003207 190.0
TLS2_k127_3753062_6 Belongs to the arginase family K01476 - 3.5.3.1 0.00000000000000000000000000000000000000000000000002031 187.0
TLS2_k127_3753062_7 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000000000000003098 184.0
TLS2_k127_3753062_8 protein conserved in bacteria - - - 0.0000000000000003609 79.0
TLS2_k127_3753062_9 - - - - 0.000000001443 67.0
TLS2_k127_3785718_0 copper-translocating P-type ATPase K01533 - 3.6.3.4 8.796e-287 895.0
TLS2_k127_3785718_1 Glucose / Sorbosone dehydrogenase K21430 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 546.0
TLS2_k127_3785718_10 Aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 316.0
TLS2_k127_3785718_11 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 303.0
TLS2_k127_3785718_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 325.0
TLS2_k127_3785718_13 Belongs to the WrbA family K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 298.0
TLS2_k127_3785718_14 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002742 267.0
TLS2_k127_3785718_15 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000001461 226.0
TLS2_k127_3785718_16 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000001578 211.0
TLS2_k127_3785718_17 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000005813 193.0
TLS2_k127_3785718_18 - - - - 0.000000000000000000000000000000000000000000000000001237 200.0
TLS2_k127_3785718_19 BlaR1 peptidase M56 - - - 0.000000000000000000000000000000000000000001991 177.0
TLS2_k127_3785718_2 sigma factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 544.0
TLS2_k127_3785718_20 Penicillinase repressor - - - 0.0000000000000000000000000000000000000002846 152.0
TLS2_k127_3785718_21 DUF218 domain - - - 0.00000000000000000000000000000000004401 145.0
TLS2_k127_3785718_22 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000003602 146.0
TLS2_k127_3785718_23 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000002878 144.0
TLS2_k127_3785718_24 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000000000000000000000702 126.0
TLS2_k127_3785718_25 ErfK ybiS ycfS ynhG family protein K19234 - - 0.0000000000000000000000000007955 123.0
TLS2_k127_3785718_26 cheY-homologous receiver domain - - - 0.000000000000000002633 92.0
TLS2_k127_3785718_27 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000001032 88.0
TLS2_k127_3785718_28 lyase activity - - - 0.000000000000001096 91.0
TLS2_k127_3785718_3 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 485.0
TLS2_k127_3785718_30 Peptidase S8 - - - 0.000000000008185 66.0
TLS2_k127_3785718_31 COG0457 FOG TPR repeat - - - 0.0000000003739 70.0
TLS2_k127_3785718_32 Sporulation related domain - - - 0.000000005356 68.0
TLS2_k127_3785718_33 - - - - 0.00003354 53.0
TLS2_k127_3785718_34 Gram-negative bacterial TonB protein C-terminal - - - 0.00009544 55.0
TLS2_k127_3785718_4 chorismate binding enzyme K01665,K02619,K03342,K13503,K13950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.85,4.1.3.27,4.1.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 485.0
TLS2_k127_3785718_5 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 452.0
TLS2_k127_3785718_6 2,3-bisphosphoglycerate-independent phosphoglycerate mutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 407.0
TLS2_k127_3785718_7 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 333.0
TLS2_k127_3785718_8 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 329.0
TLS2_k127_3785718_9 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 329.0
TLS2_k127_3844786_0 metallocarboxypeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000015 216.0
TLS2_k127_3844786_1 Outer membrane protein beta-barrel family - - - 0.0000000004542 71.0
TLS2_k127_3898808_0 TonB-dependent receptor - - - 9.569e-291 930.0
TLS2_k127_3898808_1 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 2.664e-238 759.0
TLS2_k127_3898808_10 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 429.0
TLS2_k127_3898808_11 PFAM Alcohol dehydrogenase, zinc-binding K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 381.0
TLS2_k127_3898808_12 PFAM DHH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 375.0
TLS2_k127_3898808_13 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 369.0
TLS2_k127_3898808_14 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 374.0
TLS2_k127_3898808_15 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 357.0
TLS2_k127_3898808_16 8-amino-7-oxononanoate synthase activity K00639,K00652 - 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 359.0
TLS2_k127_3898808_17 mechanosensitive ion channel K16052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 343.0
TLS2_k127_3898808_19 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 342.0
TLS2_k127_3898808_2 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 2.256e-215 682.0
TLS2_k127_3898808_20 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009587 319.0
TLS2_k127_3898808_21 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 307.0
TLS2_k127_3898808_22 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 291.0
TLS2_k127_3898808_23 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007195 291.0
TLS2_k127_3898808_24 FecCD transport family K02013,K02015 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003996 291.0
TLS2_k127_3898808_25 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003943 280.0
TLS2_k127_3898808_26 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.0000000000000000000000000000000000000000000000000000000000000000000000000000297 267.0
TLS2_k127_3898808_27 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005009 269.0
TLS2_k127_3898808_28 Peptidase family S51 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002272 272.0
TLS2_k127_3898808_29 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001022 267.0
TLS2_k127_3898808_3 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 544.0
TLS2_k127_3898808_30 Glycosyl transferase family 21 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000001043 259.0
TLS2_k127_3898808_31 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000749 240.0
TLS2_k127_3898808_32 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000004473 237.0
TLS2_k127_3898808_33 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000001827 223.0
TLS2_k127_3898808_34 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000003049 218.0
TLS2_k127_3898808_35 Glucose inhibited division protein A K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000001022 214.0
TLS2_k127_3898808_36 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000002702 209.0
TLS2_k127_3898808_37 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000007956 194.0
TLS2_k127_3898808_38 PFAM dehydrogenase, E1 component - - - 0.00000000000000000000000000000000000000000000000007557 195.0
TLS2_k127_3898808_39 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000004115 199.0
TLS2_k127_3898808_4 Anthranilate synthase component I, N terminal region K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 506.0
TLS2_k127_3898808_40 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000001846 171.0
TLS2_k127_3898808_41 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000001153 163.0
TLS2_k127_3898808_42 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.00000000000000000000000000000000000006563 151.0
TLS2_k127_3898808_43 NUDIX domain - - - 0.000000000000000000000000000000000000123 152.0
TLS2_k127_3898808_44 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.000000000000000000000000000000000001562 143.0
TLS2_k127_3898808_45 Flavin reductase like domain - - - 0.000000000000000000000000000000000007108 145.0
TLS2_k127_3898808_46 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000823 150.0
TLS2_k127_3898808_47 NUDIX domain - - - 0.0000000000000000000000000000000002435 140.0
TLS2_k127_3898808_48 HIT domain K02503 - - 0.0000000000000000000000000000000003638 137.0
TLS2_k127_3898808_49 EamA-like transporter family - - - 0.00000000000000000000000000000005082 140.0
TLS2_k127_3898808_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 501.0
TLS2_k127_3898808_50 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000001923 128.0
TLS2_k127_3898808_51 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000001543 137.0
TLS2_k127_3898808_52 Predicted integral membrane protein (DUF2270) - - - 0.00000000000000000000000000002452 130.0
TLS2_k127_3898808_53 HNH nucleases - - - 0.00000000000000000001036 98.0
TLS2_k127_3898808_54 Cysteine-rich secretory protein family - - - 0.00000000000000001155 91.0
TLS2_k127_3898808_55 - - - - 0.00000000000000007276 89.0
TLS2_k127_3898808_57 - - - - 0.00000000002616 74.0
TLS2_k127_3898808_58 Transglutaminase-like superfamily - - - 0.00000001025 61.0
TLS2_k127_3898808_59 Protein of unknown function, DUF481 - - - 0.00000001063 66.0
TLS2_k127_3898808_6 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007612 471.0
TLS2_k127_3898808_60 AMP binding - - - 0.0000001776 59.0
TLS2_k127_3898808_61 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0000004147 56.0
TLS2_k127_3898808_62 PFAM histone deacetylase superfamily - - - 0.000005307 51.0
TLS2_k127_3898808_7 secondary active sulfate transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 478.0
TLS2_k127_3898808_8 cobalamin-transporting ATPase activity K02014,K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 454.0
TLS2_k127_3898808_9 Sodium:sulfate symporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 451.0
TLS2_k127_3907663_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 461.0
TLS2_k127_3907663_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 417.0
TLS2_k127_3907663_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000291 113.0
TLS2_k127_3907663_11 HEPN domain K07076 - - 0.0000000000000000000000007031 115.0
TLS2_k127_3907663_12 Transcriptional regulator PadR-like family - - - 0.000000000000000000000125 101.0
TLS2_k127_3907663_13 efflux transmembrane transporter activity - - - 0.0000000000000000002341 95.0
TLS2_k127_3907663_14 negative regulation of transcription, DNA-templated K10947 - - 0.00000000000009832 73.0
TLS2_k127_3907663_15 - - - - 0.0000000005499 73.0
TLS2_k127_3907663_16 Transcriptional regulator PadR-like family - - - 0.00000133 59.0
TLS2_k127_3907663_17 nucleotidyltransferase activity K07075,K07076 - - 0.0000413 53.0
TLS2_k127_3907663_18 efflux transmembrane transporter activity - - - 0.00008091 54.0
TLS2_k127_3907663_19 Histidine kinase - - - 0.000104 48.0
TLS2_k127_3907663_2 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007083 381.0
TLS2_k127_3907663_3 Acyltransferase family K11941 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 342.0
TLS2_k127_3907663_4 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000002568 209.0
TLS2_k127_3907663_5 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000003196 187.0
TLS2_k127_3907663_6 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000007078 175.0
TLS2_k127_3907663_7 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000595 162.0
TLS2_k127_3907663_8 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000001542 129.0
TLS2_k127_3907663_9 Protein of unknown function (DUF3052) - - - 0.000000000000000000000000002008 121.0
TLS2_k127_3988431_0 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 428.0
TLS2_k127_3988431_1 Cell cycle protein K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 381.0
TLS2_k127_3988431_2 Hsp70 protein K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 334.0
TLS2_k127_3988431_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 331.0
TLS2_k127_3988431_4 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000003397 276.0
TLS2_k127_3988431_5 rod shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000000747 150.0
TLS2_k127_3996816_0 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006338 400.0
TLS2_k127_3996816_1 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 324.0
TLS2_k127_3996816_2 Diphthamide synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003318 274.0
TLS2_k127_3996816_3 Bacterial extracellular solute-binding proteins, family 3 - - - 0.000000000000000000000000000000000000000000000000000000001107 212.0
TLS2_k127_3996816_4 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000005518 147.0
TLS2_k127_3996816_5 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000003879 109.0
TLS2_k127_4063891_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 1.73e-314 983.0
TLS2_k127_4063891_1 serine-type peptidase activity - - - 3.987e-258 825.0
TLS2_k127_4063891_10 NAD(P)H quinone oxidoreductase, PIG3 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009538 344.0
TLS2_k127_4063891_11 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009957 347.0
TLS2_k127_4063891_12 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 345.0
TLS2_k127_4063891_13 tryptophan 2,3-dioxygenase activity K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007043 314.0
TLS2_k127_4063891_14 of the major facilitator superfamily K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001493 256.0
TLS2_k127_4063891_15 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004621 252.0
TLS2_k127_4063891_16 Protein of unknown function (DUF1460) - - - 0.000000000000000000000000000000000000000000000000000000000000005135 229.0
TLS2_k127_4063891_17 ArsR family transcriptional regulator - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010288,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032791,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097063,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000002276 199.0
TLS2_k127_4063891_18 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000001875 201.0
TLS2_k127_4063891_19 redox protein regulator of disulfide bond formation K04063 - - 0.000000000000000000000000000000000000000000004301 167.0
TLS2_k127_4063891_2 helicase activity - - - 4.961e-227 728.0
TLS2_k127_4063891_20 - K04517 - 1.3.1.12 0.00000000000000000000000000000000000000002151 158.0
TLS2_k127_4063891_21 PFAM OsmC family protein - - - 0.00000000000000000000000000000000000000009002 170.0
TLS2_k127_4063891_22 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000009642 157.0
TLS2_k127_4063891_23 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.0000000000000000000000000000000005265 142.0
TLS2_k127_4063891_24 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000002142 128.0
TLS2_k127_4063891_25 PilZ domain - - - 0.000000000000000000000000000002621 126.0
TLS2_k127_4063891_26 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000003796 123.0
TLS2_k127_4063891_27 Cold shock K03704 - - 0.00000000000000000000000000001205 119.0
TLS2_k127_4063891_28 - - - - 0.000000000000000000000000006725 119.0
TLS2_k127_4063891_3 Ferrous iron transport protein B K04759 - - 1.296e-210 672.0
TLS2_k127_4063891_30 RNA polymerase, sigma-24 subunit, ECF subfamily - - - 0.0000000000000000000000001367 113.0
TLS2_k127_4063891_31 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 0.000000000000000000000000576 109.0
TLS2_k127_4063891_32 SMART Metal-dependent phosphohydrolase, HD region K07141 - 2.7.7.76 0.00000000000000000000002806 108.0
TLS2_k127_4063891_33 spectrin binding K15502,K19947 - 1.14.13.225 0.000000000000000000001149 111.0
TLS2_k127_4063891_34 cheY-homologous receiver domain K11443 - - 0.00000000000000000006345 96.0
TLS2_k127_4063891_35 XdhC and CoxI family - - - 0.000000000000000000512 90.0
TLS2_k127_4063891_36 - - - - 0.00000000000000005111 92.0
TLS2_k127_4063891_37 - - - - 0.00000000000000239 85.0
TLS2_k127_4063891_38 Glycogen recognition site of AMP-activated protein kinase - - - 0.00000000000004092 82.0
TLS2_k127_4063891_39 - - - - 0.00000000002526 72.0
TLS2_k127_4063891_4 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 527.0
TLS2_k127_4063891_40 - - - - 0.0000003158 61.0
TLS2_k127_4063891_41 Transglycosylase associated protein - - - 0.00008977 49.0
TLS2_k127_4063891_42 FeoA K04758 - - 0.0001568 48.0
TLS2_k127_4063891_43 Tetratricopeptide repeat - - - 0.000307 51.0
TLS2_k127_4063891_5 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008123 507.0
TLS2_k127_4063891_6 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 443.0
TLS2_k127_4063891_7 PFAM sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 386.0
TLS2_k127_4063891_8 antibiotic catabolic process K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004963 362.0
TLS2_k127_4063891_9 antiporter K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 355.0
TLS2_k127_4073712_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 381.0
TLS2_k127_4073712_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 355.0
TLS2_k127_4073712_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000002008 236.0
TLS2_k127_4073712_3 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000006875 153.0
TLS2_k127_4073712_4 Transglutaminase-like superfamily - - - 0.0000001901 54.0
TLS2_k127_4111765_0 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000003212 224.0
TLS2_k127_4111765_1 Protein of unknown function (DUF861) - - - 0.000000000000000000000000000000000000000004003 161.0
TLS2_k127_4111765_2 - - - - 0.0000000000000000000000000000000000003343 146.0
TLS2_k127_4111765_3 DoxX K15977 - - 0.00009303 49.0
TLS2_k127_4176631_0 Heat shock 70 kDa protein K04043 - - 1.154e-254 796.0
TLS2_k127_4176631_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 4.348e-241 751.0
TLS2_k127_4176631_10 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 354.0
TLS2_k127_4176631_11 Phosphorylase superfamily K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 288.0
TLS2_k127_4176631_12 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006543 282.0
TLS2_k127_4176631_13 Phosphomethylpyrimidine kinase K00868,K00941,K03147,K21219 GO:0008150,GO:0040007 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000001234 263.0
TLS2_k127_4176631_14 PFAM Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001573 267.0
TLS2_k127_4176631_15 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006195 264.0
TLS2_k127_4176631_16 FAD dependent oxidoreductase K00285,K03153 - 1.4.3.19,1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000007887 257.0
TLS2_k127_4176631_17 Methyl-viologen-reducing hydrogenase, delta subunit K02572,K02573,K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000001707 256.0
TLS2_k127_4176631_18 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000004827 236.0
TLS2_k127_4176631_19 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.0000000000000000000000000000000000000000000000000000000000003464 221.0
TLS2_k127_4176631_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 8.818e-211 669.0
TLS2_k127_4176631_20 cytochrome c oxidase (Subunit II) - - - 0.000000000000000000000000000000000000000000000000000000008351 206.0
TLS2_k127_4176631_21 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000006976 194.0
TLS2_k127_4176631_22 PFAM PHP domain K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000002326 191.0
TLS2_k127_4176631_23 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000001893 179.0
TLS2_k127_4176631_24 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000642 179.0
TLS2_k127_4176631_25 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.00000000000000000000000000000000000000000000005474 182.0
TLS2_k127_4176631_26 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000198 173.0
TLS2_k127_4176631_27 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000003051 167.0
TLS2_k127_4176631_28 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000268 129.0
TLS2_k127_4176631_29 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000001323 100.0
TLS2_k127_4176631_3 heme-copper terminal oxidase activity K02274 - 1.9.3.1 2.414e-198 634.0
TLS2_k127_4176631_30 Membrane-bound lysozyme-inhibitor of c-type lysozyme - - - 0.00000000000000000003725 99.0
TLS2_k127_4176631_31 Intracellular proteinase inhibitor - - - 0.0000000000000001897 87.0
TLS2_k127_4176631_32 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000001483 81.0
TLS2_k127_4176631_33 - - - - 0.000000000000006783 81.0
TLS2_k127_4176631_34 ORF located using Blastx - - - 0.00000000000001146 74.0
TLS2_k127_4176631_35 SCO1/SenC - - - 0.00000000003165 74.0
TLS2_k127_4176631_36 - - - - 0.0000003706 59.0
TLS2_k127_4176631_37 - - - - 0.000008291 56.0
TLS2_k127_4176631_38 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00003329 51.0
TLS2_k127_4176631_39 - - - - 0.0001884 47.0
TLS2_k127_4176631_4 Nitronate monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 595.0
TLS2_k127_4176631_40 - - - - 0.0008255 49.0
TLS2_k127_4176631_5 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 488.0
TLS2_k127_4176631_6 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 453.0
TLS2_k127_4176631_7 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 441.0
TLS2_k127_4176631_8 Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 440.0
TLS2_k127_4176631_9 mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 384.0
TLS2_k127_4352354_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 2.849e-251 803.0
TLS2_k127_4352354_1 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 560.0
TLS2_k127_4352354_10 NADP oxidoreductase coenzyme F420-dependent - - - 0.00000000000000000000000000000000000002049 156.0
TLS2_k127_4352354_11 ZIP Zinc transporter K07238 - - 0.00000000000000000000000000000005347 135.0
TLS2_k127_4352354_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000007964 104.0
TLS2_k127_4352354_13 Late embryogenesis abundant protein - - - 0.000000000000000003107 93.0
TLS2_k127_4352354_14 Integrase core domain - - - 0.00000000001785 68.0
TLS2_k127_4352354_15 - - - - 0.0001671 51.0
TLS2_k127_4352354_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 455.0
TLS2_k127_4352354_3 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 329.0
TLS2_k127_4352354_4 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 300.0
TLS2_k127_4352354_5 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 310.0
TLS2_k127_4352354_6 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005221 273.0
TLS2_k127_4352354_7 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000000000000000000000000000000000008688 222.0
TLS2_k127_4352354_8 SIS domain K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000003718 185.0
TLS2_k127_4352354_9 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000002279 184.0
TLS2_k127_440493_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1521.0
TLS2_k127_440493_1 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007577 451.0
TLS2_k127_440493_10 PFAM response regulator receiver K02477 - - 0.0000000000000000000000000000000000000000005832 168.0
TLS2_k127_440493_11 Peptidase family S41 - - - 0.00000000000000000000000000000000000000002721 170.0
TLS2_k127_440493_12 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000006142 156.0
TLS2_k127_440493_13 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000002023 145.0
TLS2_k127_440493_14 COGs COG3324 protein related to lactoylglutathione lyase K06996 - - 0.00000000000000000000000000000003354 131.0
TLS2_k127_440493_15 Protein of unknown function (DUF3052) - - - 0.000000000000000000000000000001512 126.0
TLS2_k127_440493_16 ATP-independent chaperone mediated protein folding - - - 0.00000000000000000000000000002343 125.0
TLS2_k127_440493_17 cyclic nucleotide binding K10914,K21563 - - 0.0000000000000000000000000003379 122.0
TLS2_k127_440493_18 - - - - 0.00000000000000000000000000356 124.0
TLS2_k127_440493_19 phosphorelay signal transduction system - - - 0.00000000000000000000000002602 111.0
TLS2_k127_440493_2 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 413.0
TLS2_k127_440493_20 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000006392 113.0
TLS2_k127_440493_21 Putative esterase - - - 0.0000000000000000000005502 109.0
TLS2_k127_440493_22 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000007464 92.0
TLS2_k127_440493_23 Glucose / Sorbosone dehydrogenase - - - 0.000000000000003284 87.0
TLS2_k127_440493_24 Transcriptional regulator PadR family protein K10947 - - 0.000000000003384 70.0
TLS2_k127_440493_25 ECF sigma factor K03088 - - 0.0000000007877 64.0
TLS2_k127_440493_27 Histidine kinase K07636 - 2.7.13.3 0.0002229 48.0
TLS2_k127_440493_28 efflux transmembrane transporter activity - - - 0.0003087 50.0
TLS2_k127_440493_29 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0004623 46.0
TLS2_k127_440493_3 Peptidase family M20/M25/M40 K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 315.0
TLS2_k127_440493_30 Domain of unknown function (DU1801) - - - 0.0007743 49.0
TLS2_k127_440493_4 Pyridoxal-phosphate dependent enzyme K01751 - 4.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 294.0
TLS2_k127_440493_5 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002858 286.0
TLS2_k127_440493_6 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000002615 215.0
TLS2_k127_440493_7 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000005224 197.0
TLS2_k127_440493_8 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000001457 165.0
TLS2_k127_440493_9 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000139 175.0
TLS2_k127_4489838_0 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 466.0
TLS2_k127_4489838_1 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 301.0
TLS2_k127_4489838_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000001464 195.0
TLS2_k127_4489838_3 Acid phosphatase homologues - - - 0.0000000000000000000000000000000000000000000000003707 185.0
TLS2_k127_4489838_4 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.000000000000000000000000000000000000000000001201 180.0
TLS2_k127_4489838_5 PFAM phosphoesterase RecJ domain protein - - - 0.00000000000000000000000000000000000003515 161.0
TLS2_k127_4489838_6 Glyoxalase-like domain K05606 - 5.1.99.1 0.000000000000000000000000000001222 125.0
TLS2_k127_4489838_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000007315 105.0
TLS2_k127_4489838_8 - - - - 0.000000492 59.0
TLS2_k127_4489878_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1206.0
TLS2_k127_4489878_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002409 246.0
TLS2_k127_4502161_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1180.0
TLS2_k127_4502161_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.874e-198 630.0
TLS2_k127_4502161_2 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 625.0
TLS2_k127_4502161_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 406.0
TLS2_k127_4502161_4 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000001783 151.0
TLS2_k127_4502161_5 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.00000000000000000000000000000001826 131.0
TLS2_k127_4502161_6 - - - - 0.0000000009285 67.0
TLS2_k127_4684931_0 PFAM Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 9.562e-213 682.0
TLS2_k127_4684931_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 544.0
TLS2_k127_4684931_10 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 391.0
TLS2_k127_4684931_11 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 391.0
TLS2_k127_4684931_12 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 405.0
TLS2_k127_4684931_13 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 380.0
TLS2_k127_4684931_14 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 369.0
TLS2_k127_4684931_15 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 321.0
TLS2_k127_4684931_16 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000006182 256.0
TLS2_k127_4684931_17 (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001461 263.0
TLS2_k127_4684931_18 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000000002558 231.0
TLS2_k127_4684931_19 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000005518 222.0
TLS2_k127_4684931_2 Biotin carboxylase C-terminal domain K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 533.0
TLS2_k127_4684931_20 - - - - 0.0000000000000000000000000000000000000000000000003553 183.0
TLS2_k127_4684931_21 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000001038 179.0
TLS2_k127_4684931_22 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000001248 173.0
TLS2_k127_4684931_23 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000004623 176.0
TLS2_k127_4684931_24 PTS system sorbose subfamily IIB component K19507 - - 0.00000000000000000000000000000000000000000002698 167.0
TLS2_k127_4684931_25 PTS system mannose/fructose/sorbose family IID component K02796 - - 0.0000000000000000000000000000000000000000002723 175.0
TLS2_k127_4684931_26 Peptidase m28 - - - 0.0000000000000000000000000000000000000000005685 181.0
TLS2_k127_4684931_27 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.000000000000000000000000000000000000000001193 168.0
TLS2_k127_4684931_28 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000001248 166.0
TLS2_k127_4684931_29 TIGRFAM Diguanylate cyclase - - - 0.0000000000000000000000000000000000000722 163.0
TLS2_k127_4684931_3 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 511.0
TLS2_k127_4684931_30 Biotin-requiring enzyme - - - 0.0000000000000000000000000000000006061 138.0
TLS2_k127_4684931_31 Beta-lactamase - - - 0.000000000000000000000000000001399 135.0
TLS2_k127_4684931_32 phosphorelay signal transduction system - - - 0.000000000000000000000000000009784 122.0
TLS2_k127_4684931_33 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000376 122.0
TLS2_k127_4684931_34 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000000000003849 117.0
TLS2_k127_4684931_35 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000004121 107.0
TLS2_k127_4684931_36 KaiB K08481 - - 0.000000000000000003003 88.0
TLS2_k127_4684931_37 - - - - 0.000000000000000003213 89.0
TLS2_k127_4684931_38 Regulatory protein, FmdB family - - - 0.00000000000000001249 89.0
TLS2_k127_4684931_39 negative regulation of transcription, DNA-templated - - - 0.00000000000000003062 87.0
TLS2_k127_4684931_4 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 458.0
TLS2_k127_4684931_40 PTS system sorbose-specific iic component K02795 - - 0.00000000000000004372 90.0
TLS2_k127_4684931_41 PTS system fructose IIA component K02744 - - 0.00000000000000007083 87.0
TLS2_k127_4684931_42 - - - - 0.0000000000000008014 90.0
TLS2_k127_4684931_43 - - - - 0.0000000000000241 83.0
TLS2_k127_4684931_45 cheY-homologous receiver domain K03407,K03413 - 2.7.13.3 0.00000000005028 72.0
TLS2_k127_4684931_46 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000003393 66.0
TLS2_k127_4684931_47 C4-type zinc ribbon domain K07164 - - 0.00000003465 61.0
TLS2_k127_4684931_48 PhoQ Sensor - - - 0.0000004479 58.0
TLS2_k127_4684931_49 translation initiation factor activity - - - 0.000005648 56.0
TLS2_k127_4684931_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005545 439.0
TLS2_k127_4684931_50 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.000007388 58.0
TLS2_k127_4684931_51 COG1544 Ribosome-associated protein Y (PSrp-1) K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.0005687 47.0
TLS2_k127_4684931_52 Histidine kinase - - - 0.00085 45.0
TLS2_k127_4684931_6 elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 432.0
TLS2_k127_4684931_7 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 426.0
TLS2_k127_4684931_8 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 410.0
TLS2_k127_4684931_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 414.0
TLS2_k127_4771281_0 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 599.0
TLS2_k127_4771281_1 Putative modulator of DNA gyrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 527.0
TLS2_k127_4771281_10 Belongs to the bacterial solute-binding protein 9 family - - - 0.0000000000000000000000000000000000000000000148 187.0
TLS2_k127_4771281_11 Diguanylate cyclase phosphodiesterase with MHYT sensor K21023 - 2.7.7.65 0.0000000000000000000000000000000000001552 164.0
TLS2_k127_4771281_12 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000126 102.0
TLS2_k127_4771281_13 - - - - 0.00000000007407 74.0
TLS2_k127_4771281_14 Pfam:HipA_N K07154 - 2.7.11.1 0.0000000007844 62.0
TLS2_k127_4771281_15 Outer membrane protein beta-barrel domain - - - 0.000000006788 65.0
TLS2_k127_4771281_16 von Willebrand factor, type A - - - 0.0002324 54.0
TLS2_k127_4771281_2 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 441.0
TLS2_k127_4771281_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 406.0
TLS2_k127_4771281_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006862 424.0
TLS2_k127_4771281_5 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 359.0
TLS2_k127_4771281_6 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000265 296.0
TLS2_k127_4771281_7 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001819 295.0
TLS2_k127_4771281_8 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000006744 181.0
TLS2_k127_4771281_9 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000003657 195.0
TLS2_k127_4778716_0 Phage integrase, N-terminal SAM-like domain K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003535 284.0
TLS2_k127_4778716_1 DinB superfamily - - - 0.00000000000000000000000000000000000001032 150.0
TLS2_k127_4778716_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000002196 99.0
TLS2_k127_4789121_0 PFAM NADH flavin oxidoreductase NADH oxidase K00219,K09461 - 1.14.13.40,1.3.1.34 1.49e-302 949.0
TLS2_k127_4789121_1 PFAM sodium hydrogen exchanger - - - 1.25e-260 823.0
TLS2_k127_4789121_10 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 292.0
TLS2_k127_4789121_11 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000616 282.0
TLS2_k127_4789121_12 cAMP biosynthetic process K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000002725 259.0
TLS2_k127_4789121_13 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000001191 246.0
TLS2_k127_4789121_14 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000005427 192.0
TLS2_k127_4789121_15 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000001513 191.0
TLS2_k127_4789121_16 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000004181 169.0
TLS2_k127_4789121_17 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000003492 181.0
TLS2_k127_4789121_18 LemA family K03744 - - 0.00000000000000000000000000000000000000001656 166.0
TLS2_k127_4789121_19 TPM domain K06872 - - 0.000000000000000000000000000000000000001513 163.0
TLS2_k127_4789121_2 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 4.191e-214 684.0
TLS2_k127_4789121_20 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000001188 136.0
TLS2_k127_4789121_21 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000363 129.0
TLS2_k127_4789121_22 nucleotidyltransferase activity - - - 0.00000000000000000000000000007997 125.0
TLS2_k127_4789121_23 - - - - 0.00000000000000000003494 106.0
TLS2_k127_4789121_24 Transcriptional regulator, GntR family K03710 - - 0.000000002438 68.0
TLS2_k127_4789121_25 Tetratricopeptide repeat-like domain - - - 0.0000003906 61.0
TLS2_k127_4789121_26 NHL repeat - - - 0.000002969 59.0
TLS2_k127_4789121_27 CHAT domain - - - 0.00000419 49.0
TLS2_k127_4789121_3 NAD synthase K01916 - 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 611.0
TLS2_k127_4789121_4 Acyl-CoA dehydrogenase, middle domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 440.0
TLS2_k127_4789121_5 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008165 438.0
TLS2_k127_4789121_6 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 404.0
TLS2_k127_4789121_7 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 407.0
TLS2_k127_4789121_8 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 355.0
TLS2_k127_4789121_9 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 353.0
TLS2_k127_4806371_0 Acetyl xylan esterase (AXE1) - - - 6.894e-300 934.0
TLS2_k127_4806371_1 DNA topoisomerase II activity K02469 - 5.99.1.3 2.477e-268 850.0
TLS2_k127_4806371_10 ATP dependent DNA ligase C terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 511.0
TLS2_k127_4806371_11 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003924 506.0
TLS2_k127_4806371_12 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003724 473.0
TLS2_k127_4806371_13 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 454.0
TLS2_k127_4806371_14 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 439.0
TLS2_k127_4806371_15 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 436.0
TLS2_k127_4806371_16 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 436.0
TLS2_k127_4806371_17 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009526 424.0
TLS2_k127_4806371_18 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007448 400.0
TLS2_k127_4806371_19 phenylacetic acid catabolic K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007427 394.0
TLS2_k127_4806371_2 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 5.031e-248 792.0
TLS2_k127_4806371_20 COGs COG4299 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 389.0
TLS2_k127_4806371_21 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 350.0
TLS2_k127_4806371_22 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 357.0
TLS2_k127_4806371_23 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 319.0
TLS2_k127_4806371_24 protein histidine kinase activity K03407,K07678 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 318.0
TLS2_k127_4806371_25 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 305.0
TLS2_k127_4806371_26 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005746 314.0
TLS2_k127_4806371_27 Peptidase M15 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 296.0
TLS2_k127_4806371_28 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 302.0
TLS2_k127_4806371_29 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001047 271.0
TLS2_k127_4806371_3 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 3.519e-240 769.0
TLS2_k127_4806371_30 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002678 260.0
TLS2_k127_4806371_31 metallophosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001732 260.0
TLS2_k127_4806371_32 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003889 252.0
TLS2_k127_4806371_33 Rhodanese Homology Domain K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000001602 255.0
TLS2_k127_4806371_34 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000179 212.0
TLS2_k127_4806371_35 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000002522 201.0
TLS2_k127_4806371_36 NmrA-like family K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000001409 184.0
TLS2_k127_4806371_37 UPF0316 protein - - - 0.0000000000000000000000000000000000000000000004655 173.0
TLS2_k127_4806371_38 Peptidase m28 - - - 0.00000000000000000000000000000000000000000006845 180.0
TLS2_k127_4806371_39 Transcription elongation factor, N-terminal K03624 - - 0.000000000000000000000000000000000000000003695 161.0
TLS2_k127_4806371_4 Sodium:solute symporter family - - - 8.953e-238 747.0
TLS2_k127_4806371_40 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000003597 162.0
TLS2_k127_4806371_41 DbpA RNA binding domain K05592 - 3.6.4.13 0.0000000000000000000000000000000000000001982 169.0
TLS2_k127_4806371_42 COG2801 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000001247 149.0
TLS2_k127_4806371_43 - - - - 0.0000000000000000000000000000000000000098 156.0
TLS2_k127_4806371_44 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.0000000000000000000000000000000000002532 154.0
TLS2_k127_4806371_45 Low molecular weight phosphotyrosine protein phosphatase K01104 - 3.1.3.48 0.0000000000000000000000000000000000009318 145.0
TLS2_k127_4806371_46 PFAM phenylacetic acid catabolic family protein K02611 - 1.14.13.149 0.000000000000000000000000000000000001762 150.0
TLS2_k127_4806371_47 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000003602 141.0
TLS2_k127_4806371_48 DNA-templated transcription, initiation K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000004528 134.0
TLS2_k127_4806371_49 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000485 138.0
TLS2_k127_4806371_5 TonB-dependent receptor - - - 9.985e-235 760.0
TLS2_k127_4806371_50 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000004656 128.0
TLS2_k127_4806371_51 Transglycosylase SLT domain - - - 0.000000000000000000000000000001305 130.0
TLS2_k127_4806371_52 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000006971 122.0
TLS2_k127_4806371_53 Pfam:DUF59 K02612 - - 0.00000000000000000000000000001474 125.0
TLS2_k127_4806371_54 Belongs to the UPF0761 family K07058 - - 0.0000000000000000000000000004047 124.0
TLS2_k127_4806371_55 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000002505 122.0
TLS2_k127_4806371_56 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000325 109.0
TLS2_k127_4806371_57 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00112 - 1.1.5.3 0.0000000000000000000000003432 117.0
TLS2_k127_4806371_58 metal-sulfur cluster biosynthetic - - - 0.0000000000000000000000008727 108.0
TLS2_k127_4806371_59 RDD family - - - 0.00000000000000000000000219 110.0
TLS2_k127_4806371_6 3-isopropylmalate dehydratase activity K01681,K01703,K01704,K17749 - 4.2.1.3,4.2.1.33,4.2.1.35 2.666e-219 704.0
TLS2_k127_4806371_61 chaperone-mediated protein folding - - - 0.000000000000000000001933 98.0
TLS2_k127_4806371_62 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000001084 100.0
TLS2_k127_4806371_63 Protein of unknown function (DUF1207) - - - 0.000000000000000003444 97.0
TLS2_k127_4806371_65 CAAX protease self-immunity - - - 0.0000000000000001873 88.0
TLS2_k127_4806371_66 DSBA-like thioredoxin domain - - - 0.000000000000001421 89.0
TLS2_k127_4806371_67 with the alpha beta hydrolase fold K01046 - 3.1.1.3 0.000000000000004789 85.0
TLS2_k127_4806371_68 - - - - 0.0000000000001243 75.0
TLS2_k127_4806371_69 enzyme of phenylacetate metabolism - - - 0.000000000003517 69.0
TLS2_k127_4806371_7 POT family K03305 - - 4.664e-194 623.0
TLS2_k127_4806371_70 PFAM Heavy metal transport detoxification protein K07213 - - 0.00000000002068 67.0
TLS2_k127_4806371_74 metal-sulfur cluster biosynthetic enzyme - - - 0.00000008033 55.0
TLS2_k127_4806371_76 Yip1 domain - - - 0.0000008759 59.0
TLS2_k127_4806371_77 - - - - 0.0000009148 59.0
TLS2_k127_4806371_8 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 537.0
TLS2_k127_4806371_9 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 532.0
TLS2_k127_4863008_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.111e-316 992.0
TLS2_k127_4863008_1 glutamine synthetase K01915 - 6.3.1.2 3.539e-304 947.0
TLS2_k127_4863008_10 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 338.0
TLS2_k127_4863008_11 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 317.0
TLS2_k127_4863008_12 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 302.0
TLS2_k127_4863008_13 O-acyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 295.0
TLS2_k127_4863008_14 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000001815 270.0
TLS2_k127_4863008_15 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000001584 246.0
TLS2_k127_4863008_16 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000006474 235.0
TLS2_k127_4863008_17 extracellular solute-binding protein, family 1 K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000326 239.0
TLS2_k127_4863008_18 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02045,K02049,K02068,K02071,K06857,K10112,K11072 - 3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000002722 239.0
TLS2_k127_4863008_19 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000008592 229.0
TLS2_k127_4863008_2 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 2.12e-220 696.0
TLS2_k127_4863008_20 GGDEF domain K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000003293 228.0
TLS2_k127_4863008_21 COGs COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000009926 237.0
TLS2_k127_4863008_22 Beta-lactamase K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000002478 221.0
TLS2_k127_4863008_23 spore germination - - - 0.000000000000000000000000000000000000000000000000000000003748 211.0
TLS2_k127_4863008_24 Zn peptidase - - - 0.00000000000000000000000000000000000000000000000006011 194.0
TLS2_k127_4863008_25 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000002056 186.0
TLS2_k127_4863008_26 BadF/BadG/BcrA/BcrD ATPase family K18676 - 2.7.1.8 0.00000000000000000000000000000000000000000000002021 186.0
TLS2_k127_4863008_27 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000003828 173.0
TLS2_k127_4863008_28 NlpC P60 family protein - - - 0.000000000000000000000000000000000000000000006805 176.0
TLS2_k127_4863008_29 - - - - 0.00000000000000000000000000000000000000000001507 167.0
TLS2_k127_4863008_3 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 6.114e-209 685.0
TLS2_k127_4863008_30 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000000000000000000000000000000000001516 156.0
TLS2_k127_4863008_31 ANTAR - - - 0.00000000000000000000000000000000000000002892 164.0
TLS2_k127_4863008_32 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000000000000000003254 152.0
TLS2_k127_4863008_33 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000007382 162.0
TLS2_k127_4863008_34 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K00950,K13940 - 2.7.6.3,4.1.2.25 0.00000000000000000000000000000000000007568 151.0
TLS2_k127_4863008_35 Ferric uptake regulator family K09825 - - 0.000000000000000000000000000000002188 134.0
TLS2_k127_4863008_36 Phosphoglycerate mutase family - - - 0.000000000000000000000000000001858 128.0
TLS2_k127_4863008_37 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000003739 116.0
TLS2_k127_4863008_38 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000002017 106.0
TLS2_k127_4863008_4 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 599.0
TLS2_k127_4863008_40 - - - - 0.000000000000036 83.0
TLS2_k127_4863008_41 - - - - 0.00000000001509 72.0
TLS2_k127_4863008_42 Chitinase class I K03791 - - 0.00000000005473 76.0
TLS2_k127_4863008_43 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000119 64.0
TLS2_k127_4863008_45 23S rRNA-intervening sequence protein - - - 0.0002089 49.0
TLS2_k127_4863008_5 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 566.0
TLS2_k127_4863008_6 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 525.0
TLS2_k127_4863008_7 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 428.0
TLS2_k127_4863008_8 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 421.0
TLS2_k127_4863008_9 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 383.0
TLS2_k127_4870343_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.237e-212 693.0
TLS2_k127_4870343_1 cystathionine K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 519.0
TLS2_k127_4870343_10 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000003979 85.0
TLS2_k127_4870343_11 ATP:ADP antiporter activity K03301 - - 0.00000004413 67.0
TLS2_k127_4870343_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 385.0
TLS2_k127_4870343_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005963 294.0
TLS2_k127_4870343_4 ATP-binding region ATPase domain protein K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000003279 192.0
TLS2_k127_4870343_5 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000005174 176.0
TLS2_k127_4870343_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000002962 160.0
TLS2_k127_4870343_7 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000001158 151.0
TLS2_k127_4870343_8 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000004732 121.0
TLS2_k127_4870343_9 Domain of unknown function (DUF4126) - - - 0.000000000000000000001593 106.0
TLS2_k127_4895523_0 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007161 505.0
TLS2_k127_4895523_1 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 451.0
TLS2_k127_4895523_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 430.0
TLS2_k127_4895523_3 Oxidoreductase molybdopterin binding domain K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 297.0
TLS2_k127_4895523_4 nuclear chromosome segregation - - - 0.0006797 48.0
TLS2_k127_4980045_0 Belongs to the malate synthase family K01638 - 2.3.3.9 1.452e-283 887.0
TLS2_k127_4980045_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 1.18e-196 625.0
TLS2_k127_4980045_10 Outer membrane protein beta-barrel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 431.0
TLS2_k127_4980045_11 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007236 362.0
TLS2_k127_4980045_12 Membrane-bound serine protease (ClpP class) K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 334.0
TLS2_k127_4980045_13 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 308.0
TLS2_k127_4980045_14 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000103 287.0
TLS2_k127_4980045_15 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000001157 191.0
TLS2_k127_4980045_16 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000001218 148.0
TLS2_k127_4980045_17 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000003096 134.0
TLS2_k127_4980045_2 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009968 547.0
TLS2_k127_4980045_3 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 494.0
TLS2_k127_4980045_4 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 496.0
TLS2_k127_4980045_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 471.0
TLS2_k127_4980045_6 RecQ zinc-binding K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008154 456.0
TLS2_k127_4980045_7 UPF0365 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 425.0
TLS2_k127_4980045_8 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 433.0
TLS2_k127_4980045_9 Beta-ketoacyl synthase, N-terminal domain K02615 - 2.3.1.174,2.3.1.223 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 437.0
TLS2_k127_5142927_0 Elongation factor G C-terminus K06207 - - 3.264e-277 863.0
TLS2_k127_5142927_1 DNA-directed DNA polymerase activity K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 1.307e-254 826.0
TLS2_k127_5142927_10 Protein of unknown function (DUF402) K09145 - - 0.0000001532 61.0
TLS2_k127_5142927_11 Domain of unknown function (DUF4837) - - - 0.000006775 58.0
TLS2_k127_5142927_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 550.0
TLS2_k127_5142927_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 448.0
TLS2_k127_5142927_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 373.0
TLS2_k127_5142927_5 PSP1 C-terminal conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 311.0
TLS2_k127_5142927_6 cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005932 276.0
TLS2_k127_5142927_7 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000441 181.0
TLS2_k127_5142927_8 Peptidase family M23 - - - 0.0000000000000000000000000000000000000008497 161.0
TLS2_k127_5142927_9 PFAM DSBA oxidoreductase - - - 0.0000000000000000000000000005217 122.0
TLS2_k127_52671_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1221.0
TLS2_k127_52671_1 Serine aminopeptidase, S33 K19707 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 427.0
TLS2_k127_52671_10 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000002137 149.0
TLS2_k127_52671_11 Diguanylate cyclase K07315 - 3.1.3.3 0.0000000000000000000000000000000004483 147.0
TLS2_k127_52671_13 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000147 98.0
TLS2_k127_52671_14 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000809 83.0
TLS2_k127_52671_16 Cupin 2, conserved barrel domain protein - - - 0.000000000000761 73.0
TLS2_k127_52671_17 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000009713 77.0
TLS2_k127_52671_18 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000002186 59.0
TLS2_k127_52671_19 - - - - 0.00004089 53.0
TLS2_k127_52671_2 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 436.0
TLS2_k127_52671_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 372.0
TLS2_k127_52671_4 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 325.0
TLS2_k127_52671_5 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002673 305.0
TLS2_k127_52671_6 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005001 304.0
TLS2_k127_52671_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 293.0
TLS2_k127_52671_8 Cytochrome C and Quinol oxidase polypeptide I - - - 0.00000000000000000000000000000000000000000000000317 176.0
TLS2_k127_52671_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000001864 180.0
TLS2_k127_5291510_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.236e-284 880.0
TLS2_k127_5291510_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 4.819e-266 833.0
TLS2_k127_5291510_10 Aminoacyl tRNA synthetase class II, N-terminal domain K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 370.0
TLS2_k127_5291510_11 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005242 348.0
TLS2_k127_5291510_12 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 337.0
TLS2_k127_5291510_13 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 296.0
TLS2_k127_5291510_14 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000001495 237.0
TLS2_k127_5291510_15 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000002337 235.0
TLS2_k127_5291510_16 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000103 232.0
TLS2_k127_5291510_17 SecD/SecF GG Motif K03074 - - 0.000000000000000000000000000000000000000000000000000000000000001307 230.0
TLS2_k127_5291510_18 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000006033 224.0
TLS2_k127_5291510_19 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000001168 234.0
TLS2_k127_5291510_2 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.836e-244 776.0
TLS2_k127_5291510_20 Hydrolase, TatD family K03424 - - 0.000000000000000000000000000000000000000000000000000000000000516 220.0
TLS2_k127_5291510_21 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000002838 146.0
TLS2_k127_5291510_22 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000157 135.0
TLS2_k127_5291510_23 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.000000000000000000000000000000004508 140.0
TLS2_k127_5291510_24 Metal-independent alpha-mannosidase (GH125) - - - 0.000000000000000007442 94.0
TLS2_k127_5291510_25 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000001001 82.0
TLS2_k127_5291510_26 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000001374 74.0
TLS2_k127_5291510_27 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000007591 57.0
TLS2_k127_5291510_28 23S rRNA-intervening sequence protein - - - 0.0000003519 59.0
TLS2_k127_5291510_3 B3/4 domain K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 594.0
TLS2_k127_5291510_4 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 569.0
TLS2_k127_5291510_5 CarboxypepD_reg-like domain K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 556.0
TLS2_k127_5291510_6 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000696 536.0
TLS2_k127_5291510_7 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 518.0
TLS2_k127_5291510_8 Glycosyl transferase 4-like K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 425.0
TLS2_k127_5291510_9 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 387.0
TLS2_k127_5360869_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 411.0
TLS2_k127_5360869_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000003051 237.0
TLS2_k127_5360869_2 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000002743 167.0
TLS2_k127_5360869_3 - - - - 0.000004353 59.0
TLS2_k127_5360869_4 Transcriptional regulator, GntR family - - - 0.000233 51.0
TLS2_k127_5379542_0 Amidohydrolase family - - - 0.0 1343.0
TLS2_k127_5379542_1 Amidohydrolase family - - - 0.0 1207.0
TLS2_k127_5379542_10 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 443.0
TLS2_k127_5379542_11 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 442.0
TLS2_k127_5379542_12 Thiolase, C-terminal domain K00626,K07508 - 2.3.1.16,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 423.0
TLS2_k127_5379542_13 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 422.0
TLS2_k127_5379542_14 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 387.0
TLS2_k127_5379542_15 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 393.0
TLS2_k127_5379542_16 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008314 380.0
TLS2_k127_5379542_17 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 370.0
TLS2_k127_5379542_18 VWA domain containing CoxE-like protein K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 381.0
TLS2_k127_5379542_19 Dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008077 362.0
TLS2_k127_5379542_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 4.482e-298 930.0
TLS2_k127_5379542_20 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 348.0
TLS2_k127_5379542_21 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 332.0
TLS2_k127_5379542_22 PFAM sigma-54 factor interaction domain-containing protein K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 344.0
TLS2_k127_5379542_23 Phenazine biosynthesis-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 330.0
TLS2_k127_5379542_24 Putative RNA methylase family UPF0020 K07444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004798 319.0
TLS2_k127_5379542_25 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 320.0
TLS2_k127_5379542_26 Asparaginase K01444 - 3.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 314.0
TLS2_k127_5379542_27 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 298.0
TLS2_k127_5379542_28 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007678 301.0
TLS2_k127_5379542_29 aminotransferase K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003904 283.0
TLS2_k127_5379542_3 Dehydrogenase K00117 - 1.1.5.2 1.167e-198 640.0
TLS2_k127_5379542_30 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009892 265.0
TLS2_k127_5379542_31 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003484 271.0
TLS2_k127_5379542_32 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001864 258.0
TLS2_k127_5379542_33 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000002604 230.0
TLS2_k127_5379542_34 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000004034 227.0
TLS2_k127_5379542_35 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000001601 229.0
TLS2_k127_5379542_36 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000002188 218.0
TLS2_k127_5379542_37 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000007948 203.0
TLS2_k127_5379542_38 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000006817 188.0
TLS2_k127_5379542_39 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000008442 178.0
TLS2_k127_5379542_4 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008887 587.0
TLS2_k127_5379542_40 Putative stress-induced transcription regulator - - - 0.00000000000000000000000000000000000000000001258 169.0
TLS2_k127_5379542_41 HEAT repeats - - - 0.000000000000000000000000000000000000000008701 166.0
TLS2_k127_5379542_42 Protein of unknown function, DUF - - - 0.0000000000000000000000000000000000005639 148.0
TLS2_k127_5379542_43 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000001564 141.0
TLS2_k127_5379542_44 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000001419 108.0
TLS2_k127_5379542_45 Putative adhesin - - - 0.00000000000000000000003127 114.0
TLS2_k127_5379542_46 PFAM General secretory system II protein E domain protein - - - 0.00000000000000000000029 111.0
TLS2_k127_5379542_47 alpha beta hydrolase fold - - - 0.00000000000000000003268 106.0
TLS2_k127_5379542_48 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000001179 94.0
TLS2_k127_5379542_49 - - - - 0.0000000000000000001242 100.0
TLS2_k127_5379542_5 all-trans-retinol 13,14-reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 559.0
TLS2_k127_5379542_50 - - - - 0.0000000000000001506 89.0
TLS2_k127_5379542_51 - - - - 0.0000000000001949 75.0
TLS2_k127_5379542_52 - - - - 0.000000000002051 77.0
TLS2_k127_5379542_53 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.0000002191 60.0
TLS2_k127_5379542_54 - - - - 0.00003081 55.0
TLS2_k127_5379542_55 repeat-containing protein - - - 0.000031 56.0
TLS2_k127_5379542_56 SprT-like family - - - 0.0002612 52.0
TLS2_k127_5379542_6 Glycosyl hydrolase-like 10 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 524.0
TLS2_k127_5379542_7 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 472.0
TLS2_k127_5379542_8 Carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 456.0
TLS2_k127_5379542_9 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 437.0
TLS2_k127_5406298_0 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.000000000000000001599 87.0
TLS2_k127_5406298_2 Tetratricopeptide repeat - - - 0.000007387 58.0
TLS2_k127_54251_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 626.0
TLS2_k127_54251_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 578.0
TLS2_k127_54251_10 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 374.0
TLS2_k127_54251_11 Surface antigen K07277,K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 356.0
TLS2_k127_54251_12 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 322.0
TLS2_k127_54251_13 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 315.0
TLS2_k127_54251_14 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 324.0
TLS2_k127_54251_15 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 307.0
TLS2_k127_54251_16 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001039 272.0
TLS2_k127_54251_17 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000002833 266.0
TLS2_k127_54251_19 Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) K07337,K21008 GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000001748 230.0
TLS2_k127_54251_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 519.0
TLS2_k127_54251_20 Domain of unknown function (DUF4912) K02040 - - 0.00000000000000000000000000000000000000000000000000000002866 213.0
TLS2_k127_54251_21 - - - - 0.0000000000000000000000000000000000000000000000000000005157 211.0
TLS2_k127_54251_22 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000002692 190.0
TLS2_k127_54251_23 Protein of unknown function (DUF520) K09767 - - 0.000000000000000000000000000000000000000000000001996 191.0
TLS2_k127_54251_24 DinB family - - - 0.00000000000000000000000000000000000000000000001943 176.0
TLS2_k127_54251_25 lipid kinase activity - - - 0.0000000000000000000000000000000000000000000005177 184.0
TLS2_k127_54251_26 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000005179 173.0
TLS2_k127_54251_27 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000005756 178.0
TLS2_k127_54251_28 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000000000000000000000000000001045 166.0
TLS2_k127_54251_29 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - - 0.0000000000000000000000000000000000000000003839 168.0
TLS2_k127_54251_3 Winged helix DNA-binding domain K09927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 484.0
TLS2_k127_54251_30 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000001121 159.0
TLS2_k127_54251_31 Glutathione peroxidase - - - 0.0000000000000000000000000000000253 134.0
TLS2_k127_54251_32 DNA-templated transcription, termination K03628 - - 0.0000000000000000000000000000007735 133.0
TLS2_k127_54251_33 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000676 117.0
TLS2_k127_54251_34 protein conserved in bacteria K09859 - - 0.0000000000000001268 93.0
TLS2_k127_54251_35 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.00000000000007142 76.0
TLS2_k127_54251_36 PFAM YbbR family protein - - - 0.000000000006871 74.0
TLS2_k127_54251_37 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000741 74.0
TLS2_k127_54251_38 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000001101 76.0
TLS2_k127_54251_4 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 452.0
TLS2_k127_54251_5 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 440.0
TLS2_k127_54251_6 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 424.0
TLS2_k127_54251_7 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005009 389.0
TLS2_k127_54251_8 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 362.0
TLS2_k127_54251_9 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 351.0
TLS2_k127_54704_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 6.02e-296 929.0
TLS2_k127_54704_1 Protein tyrosine kinase K12132 - 2.7.11.1 1.872e-201 661.0
TLS2_k127_54704_10 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 301.0
TLS2_k127_54704_11 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 289.0
TLS2_k127_54704_12 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001127 284.0
TLS2_k127_54704_13 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000007255 265.0
TLS2_k127_54704_14 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000001562 266.0
TLS2_k127_54704_15 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002279 260.0
TLS2_k127_54704_16 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001453 270.0
TLS2_k127_54704_17 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000898 241.0
TLS2_k127_54704_18 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000008661 219.0
TLS2_k127_54704_19 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000002059 214.0
TLS2_k127_54704_2 adenylosuccinate lyase K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 565.0
TLS2_k127_54704_20 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.0000000000000000000000000000000000001009 150.0
TLS2_k127_54704_21 RNA-binding protein homologous to eukaryotic snRNP - - - 0.0000000000000000000000000000000000006519 158.0
TLS2_k127_54704_22 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000031 140.0
TLS2_k127_54704_23 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.0000000000000000000000000000000009908 141.0
TLS2_k127_54704_24 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000001515 95.0
TLS2_k127_54704_25 LytR cell envelope-related transcriptional attenuator - - - 0.0000000001797 67.0
TLS2_k127_54704_26 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000005209 61.0
TLS2_k127_54704_3 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 524.0
TLS2_k127_54704_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 520.0
TLS2_k127_54704_5 PFAM NAD dependent epimerase dehydratase family K18981 - 1.1.1.203 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 414.0
TLS2_k127_54704_6 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 415.0
TLS2_k127_54704_7 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 401.0
TLS2_k127_54704_8 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 358.0
TLS2_k127_54704_9 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008212 305.0
TLS2_k127_5505517_0 Amidohydrolase family - - - 0.0 1217.0
TLS2_k127_5505517_1 efflux transmembrane transporter activity - - - 3.032e-311 973.0
TLS2_k127_5505517_10 Glycine D-amino acid oxidase (deaminating) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 570.0
TLS2_k127_5505517_11 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000376 548.0
TLS2_k127_5505517_12 RecQ zinc-binding K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 553.0
TLS2_k127_5505517_13 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 529.0
TLS2_k127_5505517_14 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 549.0
TLS2_k127_5505517_15 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 501.0
TLS2_k127_5505517_16 COG1226 Kef-type K transport systems - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 497.0
TLS2_k127_5505517_17 DUF1704 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005705 495.0
TLS2_k127_5505517_18 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 452.0
TLS2_k127_5505517_19 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 435.0
TLS2_k127_5505517_2 ABC transporter transmembrane region K11085 - - 2.146e-298 927.0
TLS2_k127_5505517_20 PFAM ABC-3 protein K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 435.0
TLS2_k127_5505517_21 mismatched DNA binding K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009621 420.0
TLS2_k127_5505517_22 ABC 3 transport family K11708 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 392.0
TLS2_k127_5505517_23 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 401.0
TLS2_k127_5505517_24 PFAM ABC transporter related K11710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 376.0
TLS2_k127_5505517_25 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 406.0
TLS2_k127_5505517_26 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 381.0
TLS2_k127_5505517_27 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000866 366.0
TLS2_k127_5505517_28 Belongs to the bacterial solute-binding protein 9 family K11707 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007391 359.0
TLS2_k127_5505517_29 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 326.0
TLS2_k127_5505517_3 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 3.071e-286 891.0
TLS2_k127_5505517_30 Periplasmic binding protein domain K02058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 327.0
TLS2_k127_5505517_31 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 321.0
TLS2_k127_5505517_32 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009056 311.0
TLS2_k127_5505517_33 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 304.0
TLS2_k127_5505517_34 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 298.0
TLS2_k127_5505517_35 Serine dehydratase alpha chain K01752 - 4.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000002306 267.0
TLS2_k127_5505517_36 ABC transporter K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000003866 258.0
TLS2_k127_5505517_37 Serine dehydratase beta chain K01752 - 4.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000001019 236.0
TLS2_k127_5505517_38 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.000000000000000000000000000000000000000000000000000000000000001349 228.0
TLS2_k127_5505517_39 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000006435 204.0
TLS2_k127_5505517_4 Zinc carboxypeptidase - - - 2.91e-285 900.0
TLS2_k127_5505517_40 mechanosensitive ion channel K22044 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000007263 197.0
TLS2_k127_5505517_41 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000002537 177.0
TLS2_k127_5505517_42 sequence-specific DNA binding K03719 - - 0.00000000000000000000000000000000000000000008689 164.0
TLS2_k127_5505517_43 Peptidase M50B-like - - - 0.000000000000000000000000000000000000007365 154.0
TLS2_k127_5505517_44 Protein of unknown function (DUF4230) - - - 0.0000000000000000000000000000001303 134.0
TLS2_k127_5505517_45 PFAM Class I peptide chain release factor K15034 - - 0.000000000000000000000000000005057 129.0
TLS2_k127_5505517_46 Acid phosphatase - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000000000000000000000000000137 129.0
TLS2_k127_5505517_47 Phosphodiester glycosidase - - - 0.00000000000000000000000000001668 134.0
TLS2_k127_5505517_48 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000000000000000002939 115.0
TLS2_k127_5505517_49 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000009297 115.0
TLS2_k127_5505517_5 Zinc carboxypeptidase - - - 6.523e-240 777.0
TLS2_k127_5505517_50 hydrolase K07025 - - 0.00000000000000000004278 99.0
TLS2_k127_5505517_52 Peptidoglycan-binding domain 1 protein - - - 0.00000004323 62.0
TLS2_k127_5505517_53 PFAM blue (type 1) copper domain protein - - - 0.000004959 59.0
TLS2_k127_5505517_54 Type II secretion system (T2SS), protein F K02653 - - 0.0006339 51.0
TLS2_k127_5505517_6 Peptidase family M28 - - - 2.984e-221 701.0
TLS2_k127_5505517_7 efflux transmembrane transporter activity - - - 1.505e-217 701.0
TLS2_k127_5505517_8 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 6.931e-214 685.0
TLS2_k127_5505517_9 Bacterial protein of unknown function (DUF885) - - - 9.527e-200 649.0
TLS2_k127_5521163_0 Formyltetrahydrofolate synthetase K01938 - 6.3.4.3 4.549e-219 710.0
TLS2_k127_5521163_1 Cytochrome C assembly protein K02198,K04016 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - 2.564e-196 632.0
TLS2_k127_5521163_10 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 312.0
TLS2_k127_5521163_11 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000002903 222.0
TLS2_k127_5521163_12 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.00000000000000000000000000000000000000000000000000000000001792 224.0
TLS2_k127_5521163_13 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000002311 202.0
TLS2_k127_5521163_14 CcmB protein K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.0000000000000000000000000000000000000000000000000001911 193.0
TLS2_k127_5521163_15 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000306 179.0
TLS2_k127_5521163_16 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000006217 169.0
TLS2_k127_5521163_17 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.00000000000000000000000000000000000001925 151.0
TLS2_k127_5521163_18 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000004407 140.0
TLS2_k127_5521163_19 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000007355 139.0
TLS2_k127_5521163_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 554.0
TLS2_k127_5521163_20 COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000000004419 127.0
TLS2_k127_5521163_21 subunit of a heme lyase K02200 - - 0.00000000000000000000000000000004421 131.0
TLS2_k127_5521163_22 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000001128 71.0
TLS2_k127_5521163_3 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008213 539.0
TLS2_k127_5521163_4 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 535.0
TLS2_k127_5521163_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009159 522.0
TLS2_k127_5521163_6 Na H antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 522.0
TLS2_k127_5521163_7 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 443.0
TLS2_k127_5521163_8 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 436.0
TLS2_k127_5521163_9 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 372.0
TLS2_k127_5672401_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002033 269.0
TLS2_k127_5672401_1 - - - - 0.0000000000000000000000000000000000000000000000000000000001362 212.0
TLS2_k127_5672401_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000002261 158.0
TLS2_k127_5672401_3 PIN domain - - - 0.000000000000000000000000000000005865 135.0
TLS2_k127_5672401_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000004436 129.0
TLS2_k127_5672401_5 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000005527 87.0
TLS2_k127_5672401_6 TAP-like protein - - - 0.0000000000000000266 94.0
TLS2_k127_5672401_7 Peptidase family M3 K01392 - 3.4.24.15 0.0000000000009206 73.0
TLS2_k127_5706358_0 Tricorn protease homolog K08676 - - 0.0 1347.0
TLS2_k127_5706358_1 GGDEF domain - - - 4.986e-274 874.0
TLS2_k127_5706358_10 - - - - 0.0000000000000000000000000000000000000000000008843 182.0
TLS2_k127_5706358_11 - - - - 0.000000000000000000000000000000000000000005215 162.0
TLS2_k127_5706358_12 - - - - 0.00000000000000000000000000000000000000001255 165.0
TLS2_k127_5706358_13 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000002418 122.0
TLS2_k127_5706358_14 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000005365 122.0
TLS2_k127_5706358_15 Protein of unknown function (DUF2911) - - - 0.0000000000000000000000003245 112.0
TLS2_k127_5706358_16 Belongs to the UPF0312 family - - - 0.0000000000000003788 89.0
TLS2_k127_5706358_17 amine dehydrogenase activity - - - 0.000000000226 72.0
TLS2_k127_5706358_18 Outer membrane protein beta-barrel domain - - - 0.000000002859 66.0
TLS2_k127_5706358_19 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000009226 61.0
TLS2_k127_5706358_2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 607.0
TLS2_k127_5706358_20 NHL repeat - - - 0.0000001178 64.0
TLS2_k127_5706358_21 Domain of unknown function (DUF4437) - - - 0.0000001315 59.0
TLS2_k127_5706358_24 Carboxypeptidase regulatory-like domain - - - 0.00003081 55.0
TLS2_k127_5706358_26 ABC transporter, ATP-binding protein K01990 - - 0.0005921 45.0
TLS2_k127_5706358_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008183 392.0
TLS2_k127_5706358_4 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 324.0
TLS2_k127_5706358_5 SBF-like CPA transporter family (DUF4137) K03453,K14347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 289.0
TLS2_k127_5706358_6 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000247 275.0
TLS2_k127_5706358_7 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000006019 245.0
TLS2_k127_5706358_8 N-acetylglucosaminylinositol deacetylase activity - - - 0.0000000000000000000000000000000000000000000000000000000003424 212.0
TLS2_k127_5706358_9 Response regulator, receiver K11443 - - 0.00000000000000000000000000000000000000000000000000007587 190.0
TLS2_k127_5735982_0 Carboxyl transferase domain - - - 6.811e-237 746.0
TLS2_k127_5735982_1 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 6.142e-236 743.0
TLS2_k127_5735982_10 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000001613 183.0
TLS2_k127_5735982_11 - - - - 0.000000000000000000000000000000000000000007015 156.0
TLS2_k127_5735982_12 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000005849 152.0
TLS2_k127_5735982_13 phosphoenolpyruvate-dependent sugar phosphotransferase system K02768,K02769,K02770,K02806 - 2.7.1.202 0.00000000000000000000000000000002304 131.0
TLS2_k127_5735982_14 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000006551 97.0
TLS2_k127_5735982_15 PFAM VanZ like - - - 0.00000000002263 70.0
TLS2_k127_5735982_2 Acyclic terpene utilisation family protein AtuA - - - 1.505e-198 631.0
TLS2_k127_5735982_3 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 610.0
TLS2_k127_5735982_4 7TM receptor with intracellular HD hydrolase K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 458.0
TLS2_k127_5735982_5 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000918 385.0
TLS2_k127_5735982_6 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008301 377.0
TLS2_k127_5735982_7 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 372.0
TLS2_k127_5735982_8 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000003111 200.0
TLS2_k127_5735982_9 Belongs to the enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000006939 200.0
TLS2_k127_5747780_0 Protein kinase domain K12132 - 2.7.11.1 1.777e-279 873.0
TLS2_k127_5747780_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 537.0
TLS2_k127_5747780_10 nucleic acid-binding protein contains PIN domain - - - 0.000000000000000000000000000000006811 132.0
TLS2_k127_5747780_11 Cold shock K03704 - - 0.00000000000000000000000002031 110.0
TLS2_k127_5747780_12 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000002867 102.0
TLS2_k127_5747780_13 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000000000000002878 94.0
TLS2_k127_5747780_14 heme binding - - - 0.0000000000000000744 95.0
TLS2_k127_5747780_15 Protein of unknown function (DUF1648) - - - 0.000000000000000939 86.0
TLS2_k127_5747780_16 DNA-sulfur modification-associated - - - 0.00000002231 66.0
TLS2_k127_5747780_17 - - - - 0.0000872 51.0
TLS2_k127_5747780_18 - - - - 0.0003476 48.0
TLS2_k127_5747780_19 RING finger protein - - - 0.0005205 52.0
TLS2_k127_5747780_2 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 504.0
TLS2_k127_5747780_3 the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 470.0
TLS2_k127_5747780_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 463.0
TLS2_k127_5747780_5 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 315.0
TLS2_k127_5747780_6 Putative adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000122 263.0
TLS2_k127_5747780_7 peptidase M36 K01417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003218 270.0
TLS2_k127_5747780_8 DNA-templated transcription, initiation K02405 - - 0.00000000000000000000000000000000000000005668 162.0
TLS2_k127_5747780_9 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000281 149.0
TLS2_k127_5775841_0 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 4.9e-233 750.0
TLS2_k127_5775841_1 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 542.0
TLS2_k127_5775841_10 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000000005308 99.0
TLS2_k127_5775841_11 PFAM ABC transporter related K02074 - - 0.000000000001481 79.0
TLS2_k127_5775841_2 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 515.0
TLS2_k127_5775841_3 PFAM Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 417.0
TLS2_k127_5775841_4 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 317.0
TLS2_k127_5775841_5 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002236 283.0
TLS2_k127_5775841_6 serine-type endopeptidase activity K08372 - - 0.000000000000000000000000000000000000000000000000000000000000000000001441 249.0
TLS2_k127_5775841_7 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000007052 222.0
TLS2_k127_5775841_8 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000003873 143.0
TLS2_k127_5775841_9 Tellurite resistance protein TerB - - - 0.00000000000000000000000006816 113.0
TLS2_k127_5826984_0 Malic enzyme, NAD binding domain K00027,K00029,K00625,K04020,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 1.411e-279 878.0
TLS2_k127_5826984_1 Zn_pept - - - 6.988e-255 801.0
TLS2_k127_5826984_10 P-loop ATPase protein family K06958,K07102 GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008578 497.0
TLS2_k127_5826984_11 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 471.0
TLS2_k127_5826984_12 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 455.0
TLS2_k127_5826984_13 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 454.0
TLS2_k127_5826984_14 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 439.0
TLS2_k127_5826984_15 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007952 432.0
TLS2_k127_5826984_16 Major Facilitator K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009039 376.0
TLS2_k127_5826984_17 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 354.0
TLS2_k127_5826984_18 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009073 351.0
TLS2_k127_5826984_19 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 326.0
TLS2_k127_5826984_2 Amidohydrolase family K06015 - 3.5.1.81 3.514e-240 755.0
TLS2_k127_5826984_20 Hypothetical methyltransferase K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 337.0
TLS2_k127_5826984_21 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 315.0
TLS2_k127_5826984_22 Allophanate hydrolase subunit 2 K06350 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 321.0
TLS2_k127_5826984_23 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 317.0
TLS2_k127_5826984_24 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007877 250.0
TLS2_k127_5826984_25 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000003983 256.0
TLS2_k127_5826984_26 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001911 247.0
TLS2_k127_5826984_27 Belongs to the phosphatidylserine decarboxylase family K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000004913 233.0
TLS2_k127_5826984_28 PFAM Allophanate hydrolase subunit 1 K06351 - - 0.00000000000000000000000000000000000000000000000000000000000006715 223.0
TLS2_k127_5826984_29 Peptidase family M23 K21472 - - 0.000000000000000000000000000000000000000000000000000000001095 221.0
TLS2_k127_5826984_3 lysine biosynthetic process via aminoadipic acid - - - 1.166e-224 729.0
TLS2_k127_5826984_30 PFAM Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000008891 196.0
TLS2_k127_5826984_31 - - - - 0.0000000000000000000000000000000000000000000000000009923 198.0
TLS2_k127_5826984_32 Squalene--hopene cyclase - - - 0.0000000000000000000000000000000000000000000000000228 186.0
TLS2_k127_5826984_33 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000000003781 178.0
TLS2_k127_5826984_34 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000000001212 179.0
TLS2_k127_5826984_35 Putative tRNA binding domain K06878 - - 0.0000000000000000000000000000000000000000000001118 171.0
TLS2_k127_5826984_36 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000000000000000000000000002987 169.0
TLS2_k127_5826984_37 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000006546 173.0
TLS2_k127_5826984_38 transport protein CorA K03284 - - 0.000000000000000000000000000000000000008183 160.0
TLS2_k127_5826984_39 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000000002224 145.0
TLS2_k127_5826984_4 RecQ zinc-binding K03654 - 3.6.4.12 9.802e-215 682.0
TLS2_k127_5826984_40 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000001123 153.0
TLS2_k127_5826984_41 OmpA family K03640 - - 0.00000000000000000000000000000001988 139.0
TLS2_k127_5826984_42 PFAM regulatory protein, ArsR K03892 - - 0.00000000000000000000000000001119 123.0
TLS2_k127_5826984_43 cheY-homologous receiver domain - - - 0.00000000000000000000000000002054 121.0
TLS2_k127_5826984_44 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000000000001814 114.0
TLS2_k127_5826984_46 SusD family K21572 - - 0.00000000000000000000000006126 123.0
TLS2_k127_5826984_47 SWI complex, BAF60b domains - - - 0.00000000000000000000000006375 113.0
TLS2_k127_5826984_48 Putative lumazine-binding - - - 0.000000000000000000000006246 107.0
TLS2_k127_5826984_49 4'-phosphopantetheinyl transferase superfamily K06133 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000001324 108.0
TLS2_k127_5826984_5 TonB dependent receptor - - - 6.02e-199 656.0
TLS2_k127_5826984_50 Wd-40 repeat - - - 0.000000000000000000006959 105.0
TLS2_k127_5826984_52 Integrase core domain - - - 0.000000000000002055 78.0
TLS2_k127_5826984_54 OHCU decarboxylase K16840 - 4.1.1.97 0.0000000001121 70.0
TLS2_k127_5826984_55 Peptidoglycan hydrolase involved in the splitting of the septum during cell division K22409 - 3.5.1.28 0.0000002364 63.0
TLS2_k127_5826984_56 Tetratricopeptide repeat - - - 0.000001183 61.0
TLS2_k127_5826984_57 Integrase core domain - - - 0.0001568 48.0
TLS2_k127_5826984_6 Rhodanese Homology Domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 575.0
TLS2_k127_5826984_7 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 549.0
TLS2_k127_5826984_8 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007122 492.0
TLS2_k127_5826984_9 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 495.0
TLS2_k127_5851380_0 Amidohydrolase family - - - 1.8e-221 701.0
TLS2_k127_5851380_1 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001195 278.0
TLS2_k127_5852670_0 Protein export membrane protein - - - 0.0 1456.0
TLS2_k127_5852670_1 Zinc carboxypeptidase - - - 0.0 1105.0
TLS2_k127_5852670_10 ABC transporter, ATP-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003941 529.0
TLS2_k127_5852670_11 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 461.0
TLS2_k127_5852670_12 protein catabolic process K03420,K13525,K17681 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 407.0
TLS2_k127_5852670_13 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 415.0
TLS2_k127_5852670_14 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 366.0
TLS2_k127_5852670_15 Pfam Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 375.0
TLS2_k127_5852670_16 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 329.0
TLS2_k127_5852670_17 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001237 274.0
TLS2_k127_5852670_18 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000007614 250.0
TLS2_k127_5852670_19 Flavin-binding monooxygenase-like K07222 - - 0.000000000000000000000000000000000000000000000000000000000000001222 235.0
TLS2_k127_5852670_2 cytochrome c oxidase subunit I K02274 - 1.9.3.1 1.466e-273 856.0
TLS2_k127_5852670_20 tRNA wobble adenosine to inosine editing - - - 0.0000000000000000000000000000000000000000000000000000000000004764 218.0
TLS2_k127_5852670_21 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000000000004977 213.0
TLS2_k127_5852670_22 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000006046 211.0
TLS2_k127_5852670_23 Cupin domain - - - 0.0000000000000000000000000000000000000000000005896 170.0
TLS2_k127_5852670_24 Cytochrome c - - - 0.000000000000000000000000000000000000000000003303 171.0
TLS2_k127_5852670_25 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000005315 146.0
TLS2_k127_5852670_26 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000001585 138.0
TLS2_k127_5852670_27 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.00000000000000000000000000000003298 143.0
TLS2_k127_5852670_28 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.0000000000000000000000000000004225 135.0
TLS2_k127_5852670_29 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000002823 130.0
TLS2_k127_5852670_3 Prolyl oligopeptidase family - - - 3.888e-272 880.0
TLS2_k127_5852670_30 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000001052 112.0
TLS2_k127_5852670_31 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000002551 113.0
TLS2_k127_5852670_32 - - - - 0.000000000000000000000405 104.0
TLS2_k127_5852670_33 response to abiotic stimulus - - - 0.0000000000000000008537 96.0
TLS2_k127_5852670_34 Protein of unknown function (DUF2892) - - - 0.000000000000000001491 86.0
TLS2_k127_5852670_35 DinB superfamily - - - 0.00000000000000001656 91.0
TLS2_k127_5852670_36 transferase activity, transferring glycosyl groups - - - 0.00000000000006565 72.0
TLS2_k127_5852670_37 Ankyrin repeats (many copies) - - - 0.00000000000007659 84.0
TLS2_k127_5852670_38 Protein of unknown function (DUF4235) - - - 0.0000000000001514 75.0
TLS2_k127_5852670_39 PFAM cytochrome c, class I - - - 0.000000000003499 75.0
TLS2_k127_5852670_4 ThiC-associated domain K03147 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 3.44e-269 841.0
TLS2_k127_5852670_40 - - - - 0.00000000003129 70.0
TLS2_k127_5852670_41 lactoylglutathione lyase activity - - - 0.0000000001141 74.0
TLS2_k127_5852670_42 Protein of unknown function (DUF455) - - - 0.0000008146 58.0
TLS2_k127_5852670_5 Belongs to the sigma-70 factor family. ECF subfamily - - - 7.583e-196 618.0
TLS2_k127_5852670_6 Ferric reductase like transmembrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 582.0
TLS2_k127_5852670_7 PFAM Protein kinase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 608.0
TLS2_k127_5852670_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 572.0
TLS2_k127_5852670_9 Cation transport protein K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 548.0
TLS2_k127_5871927_0 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 348.0
TLS2_k127_5871927_1 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 314.0
TLS2_k127_5871927_10 Penicillinase repressor - - - 0.000000000000000000000000000000000000002928 151.0
TLS2_k127_5871927_11 - - - - 0.00000000000000000000000000005355 136.0
TLS2_k127_5871927_12 Uncharacterised protein, DegV family COG1307 - - - 0.0000000000000000000000001064 112.0
TLS2_k127_5871927_13 MacB-like periplasmic core domain - - - 0.0000000000000000001556 93.0
TLS2_k127_5871927_2 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 315.0
TLS2_k127_5871927_3 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004719 301.0
TLS2_k127_5871927_4 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000002498 224.0
TLS2_k127_5871927_5 abc transporter atp-binding protein K02065 - - 0.000000000000000000000000000000000000000000000000000000000001704 226.0
TLS2_k127_5871927_6 PFAM response regulator receiver K02477 - - 0.000000000000000000000000000000000000000000000000000000154 205.0
TLS2_k127_5871927_7 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000001756 200.0
TLS2_k127_5871927_8 BlaR1 peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000004077 207.0
TLS2_k127_5871927_9 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000001811 166.0
TLS2_k127_5875485_0 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000001915 214.0
TLS2_k127_5875485_1 Subtilase family - - - 0.00000000000000000000000000002051 117.0
TLS2_k127_5955039_0 transmembrane transporter activity K18138 - - 0.0 1562.0
TLS2_k127_5955039_1 AcrB/AcrD/AcrF family K03296 - - 0.0 1362.0
TLS2_k127_5955039_10 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 515.0
TLS2_k127_5955039_11 beta-N-acetylglucosaminidase K01197 - 3.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 485.0
TLS2_k127_5955039_12 fatty acid desaturase K00508 - 1.14.19.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 446.0
TLS2_k127_5955039_13 efflux transmembrane transporter activity K18300,K18308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 415.0
TLS2_k127_5955039_14 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008354 409.0
TLS2_k127_5955039_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 389.0
TLS2_k127_5955039_16 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 377.0
TLS2_k127_5955039_17 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 366.0
TLS2_k127_5955039_18 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 357.0
TLS2_k127_5955039_19 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 370.0
TLS2_k127_5955039_2 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 1.271e-285 903.0
TLS2_k127_5955039_20 PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 351.0
TLS2_k127_5955039_21 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002978 273.0
TLS2_k127_5955039_22 cellular response to dsDNA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000103 270.0
TLS2_k127_5955039_23 TM2 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003049 262.0
TLS2_k127_5955039_24 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000006606 255.0
TLS2_k127_5955039_25 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003457 250.0
TLS2_k127_5955039_26 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001094 239.0
TLS2_k127_5955039_27 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000000000000000000000000000000000007423 219.0
TLS2_k127_5955039_28 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000229 216.0
TLS2_k127_5955039_29 PFAM Formylglycine-generating sulfatase enzyme - - - 0.000000000000000000000000000000000000000000000000000000000002482 216.0
TLS2_k127_5955039_3 - - - - 9.404e-270 852.0
TLS2_k127_5955039_30 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000006372 213.0
TLS2_k127_5955039_31 Domain of unknown function (DUF305) - - - 0.000000000000000000000000000000000000000000000000000000004576 206.0
TLS2_k127_5955039_32 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000001412 205.0
TLS2_k127_5955039_33 Bacterial PH domain K08981 - - 0.0000000000000000000000000000000000000000000000000007838 192.0
TLS2_k127_5955039_34 Bacterial PH domain - - - 0.0000000000000000000000000000000000000000000000000007949 193.0
TLS2_k127_5955039_35 DinB superfamily - - - 0.00000000000000000000000000000000000000000001681 170.0
TLS2_k127_5955039_36 Superoxide dismutase K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000005835 164.0
TLS2_k127_5955039_37 Stage II sporulation protein E (SpoIIE) - - - 0.000000000000000000000000000000000000000001435 180.0
TLS2_k127_5955039_38 - - - - 0.000000000000000000000000000000000000001291 160.0
TLS2_k127_5955039_39 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000001334 154.0
TLS2_k127_5955039_4 repeat protein - - - 3.519e-245 771.0
TLS2_k127_5955039_40 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000002002 155.0
TLS2_k127_5955039_41 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000003785 149.0
TLS2_k127_5955039_42 signal sequence binding K07152 - - 0.000000000000000000000000000000000009346 148.0
TLS2_k127_5955039_43 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000004141 129.0
TLS2_k127_5955039_44 Protein of unknown function (DUF3037) - - - 0.00000000000000000000000000002775 123.0
TLS2_k127_5955039_45 Winged helix DNA-binding domain - - - 0.00000000000000000000000000171 121.0
TLS2_k127_5955039_46 Domain of unknown function (DUF4383) - - - 0.000000000000000000000000007517 114.0
TLS2_k127_5955039_47 PFAM membrane protein of K08972 - - 0.000000000000000000000000452 109.0
TLS2_k127_5955039_48 Domain of unknown function (DUF4389) - - - 0.0000000000000000000000004643 115.0
TLS2_k127_5955039_49 regulation of RNA biosynthetic process - - - 0.000000000000000000002373 102.0
TLS2_k127_5955039_5 DbpA RNA binding domain K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 3.403e-234 739.0
TLS2_k127_5955039_50 Belongs to the universal stress protein A family - - - 0.000000000000000003337 95.0
TLS2_k127_5955039_6 MatE - - - 1.173e-205 650.0
TLS2_k127_5955039_7 polysaccharide deacetylase K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009068 585.0
TLS2_k127_5955039_8 Sodium:sulfate symporter transmembrane region K03319 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 565.0
TLS2_k127_5955039_9 Fatty acid desaturase K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 522.0
TLS2_k127_5974233_0 ASPIC and UnbV - - - 0.0 1412.0
TLS2_k127_5974233_1 ASPIC and UnbV - - - 0.0 1344.0
TLS2_k127_5974233_10 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 496.0
TLS2_k127_5974233_11 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004186 443.0
TLS2_k127_5974233_12 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 428.0
TLS2_k127_5974233_13 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 382.0
TLS2_k127_5974233_14 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 359.0
TLS2_k127_5974233_15 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 344.0
TLS2_k127_5974233_16 NB-ARC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 355.0
TLS2_k127_5974233_17 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 337.0
TLS2_k127_5974233_18 Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 327.0
TLS2_k127_5974233_19 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 293.0
TLS2_k127_5974233_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1307.0
TLS2_k127_5974233_20 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 301.0
TLS2_k127_5974233_21 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002028 283.0
TLS2_k127_5974233_22 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001801 265.0
TLS2_k127_5974233_23 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000005241 197.0
TLS2_k127_5974233_24 PFAM metallophosphoesterase K07098 - - 0.0000000000000000000000000000000000000000002363 172.0
TLS2_k127_5974233_25 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.000000000000000000000000000000000002005 149.0
TLS2_k127_5974233_26 Glutathione peroxidase - - - 0.00000000000000000000000000000000006494 140.0
TLS2_k127_5974233_27 membrane K15977 - - 0.000000000000000000000000000000007002 136.0
TLS2_k127_5974233_28 hydroperoxide reductase activity K01607 - 4.1.1.44 0.0000000000000000000000000000002882 124.0
TLS2_k127_5974233_29 - - - - 0.000000000000000000000000000002643 121.0
TLS2_k127_5974233_3 TonB dependent receptor - - - 0.0 1193.0
TLS2_k127_5974233_30 - - - - 0.00000000000000000000000000002973 129.0
TLS2_k127_5974233_31 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000000001719 115.0
TLS2_k127_5974233_32 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.000000000000000000000000002895 119.0
TLS2_k127_5974233_33 PFAM peptidase K21471 - - 0.00000000000000000000000118 115.0
TLS2_k127_5974233_34 transport - - - 0.000000000000000000000001415 121.0
TLS2_k127_5974233_35 Outer membrane protein beta-barrel domain - - - 0.000000000000000000001975 100.0
TLS2_k127_5974233_36 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000000008997 87.0
TLS2_k127_5974233_37 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000002827 79.0
TLS2_k127_5974233_38 Polymer-forming cytoskeletal - - - 0.0000000000002254 79.0
TLS2_k127_5974233_39 Flavin reductase like domain - - - 0.00000000000111 76.0
TLS2_k127_5974233_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 7.54e-226 711.0
TLS2_k127_5974233_40 Belongs to the bacterial ribosomal protein bL34 family K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000001329 64.0
TLS2_k127_5974233_41 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0001301 52.0
TLS2_k127_5974233_5 MFS/sugar transport protein K16211 - - 2.202e-222 697.0
TLS2_k127_5974233_6 hydrolase activity, hydrolyzing O-glycosyl compounds K01176 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008342 610.0
TLS2_k127_5974233_7 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K21572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 584.0
TLS2_k127_5974233_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000681 536.0
TLS2_k127_5974233_9 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 518.0
TLS2_k127_6012867_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1082.0
TLS2_k127_6012867_1 Mo-molybdopterin cofactor metabolic process K03148,K03636,K21029,K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008135 540.0
TLS2_k127_6012867_10 DNA methyltransferase K07318 - 2.1.1.72 0.000000000000000000000000000000000000000000000000001032 203.0
TLS2_k127_6012867_11 Protein of unknown function (DUF423) - - - 0.000000000000000000000000000002209 127.0
TLS2_k127_6012867_12 JAB1/Mov34/MPN/PAD-1 ubiquitin protease - - - 0.0000000000000000000832 97.0
TLS2_k127_6012867_13 phosphorelay signal transduction system - - - 0.0000002125 64.0
TLS2_k127_6012867_14 - - - - 0.0000006716 54.0
TLS2_k127_6012867_15 energy transducer activity K03832 - - 0.00001771 48.0
TLS2_k127_6012867_18 - - - - 0.0002447 49.0
TLS2_k127_6012867_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 424.0
TLS2_k127_6012867_3 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 318.0
TLS2_k127_6012867_4 Putative glycosyl hydrolase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 310.0
TLS2_k127_6012867_5 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 295.0
TLS2_k127_6012867_6 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001698 289.0
TLS2_k127_6012867_7 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001644 291.0
TLS2_k127_6012867_8 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001929 236.0
TLS2_k127_6012867_9 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000003574 214.0
TLS2_k127_6149617_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 0.0 1028.0
TLS2_k127_6149617_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.073e-255 799.0
TLS2_k127_6149617_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 485.0
TLS2_k127_6149617_11 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 481.0
TLS2_k127_6149617_12 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009289 473.0
TLS2_k127_6149617_13 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007941 471.0
TLS2_k127_6149617_14 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 446.0
TLS2_k127_6149617_15 Uncharacterised protein family (UPF0182) K09118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008493 473.0
TLS2_k127_6149617_16 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 445.0
TLS2_k127_6149617_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007676 455.0
TLS2_k127_6149617_18 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 412.0
TLS2_k127_6149617_19 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 415.0
TLS2_k127_6149617_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 6.007e-213 683.0
TLS2_k127_6149617_20 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 411.0
TLS2_k127_6149617_21 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 402.0
TLS2_k127_6149617_22 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 399.0
TLS2_k127_6149617_23 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 393.0
TLS2_k127_6149617_24 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 393.0
TLS2_k127_6149617_25 SIS domain K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 371.0
TLS2_k127_6149617_26 Fumarate reductase, iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 367.0
TLS2_k127_6149617_27 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009909 364.0
TLS2_k127_6149617_28 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007673 356.0
TLS2_k127_6149617_29 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 367.0
TLS2_k127_6149617_3 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 598.0
TLS2_k127_6149617_30 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K02851 - 2.7.8.33,2.7.8.35,5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 354.0
TLS2_k127_6149617_31 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 304.0
TLS2_k127_6149617_32 DAHP synthetase I family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005103 305.0
TLS2_k127_6149617_33 dUTPase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 288.0
TLS2_k127_6149617_34 Bacterial membrane protein YfhO - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003227 308.0
TLS2_k127_6149617_35 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005618 286.0
TLS2_k127_6149617_36 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001483 284.0
TLS2_k127_6149617_37 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003707 274.0
TLS2_k127_6149617_38 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000026 277.0
TLS2_k127_6149617_39 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004653 271.0
TLS2_k127_6149617_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 587.0
TLS2_k127_6149617_40 Peptidase C26 K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000001284 264.0
TLS2_k127_6149617_41 Acyl transferase domain K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000008792 274.0
TLS2_k127_6149617_42 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000007979 263.0
TLS2_k127_6149617_43 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000008031 224.0
TLS2_k127_6149617_44 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.0000000000000000000000000000000000000000000000000000000000004645 218.0
TLS2_k127_6149617_45 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000004078 216.0
TLS2_k127_6149617_46 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000397 207.0
TLS2_k127_6149617_47 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000006656 201.0
TLS2_k127_6149617_48 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000005903 192.0
TLS2_k127_6149617_49 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - 0.000000000000000000000000000000000000000000000000009484 194.0
TLS2_k127_6149617_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 511.0
TLS2_k127_6149617_50 NDK K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000001027 180.0
TLS2_k127_6149617_51 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000004055 171.0
TLS2_k127_6149617_52 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000002191 163.0
TLS2_k127_6149617_53 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000003475 168.0
TLS2_k127_6149617_54 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000001293 147.0
TLS2_k127_6149617_55 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.00000000000000000000000000000000000226 141.0
TLS2_k127_6149617_56 SNARE associated Golgi protein - - - 0.000000000000000000000000000000001476 137.0
TLS2_k127_6149617_57 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000000000002338 125.0
TLS2_k127_6149617_58 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000002055 134.0
TLS2_k127_6149617_59 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000002161 124.0
TLS2_k127_6149617_6 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 522.0
TLS2_k127_6149617_60 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000003004 115.0
TLS2_k127_6149617_61 MoaE protein K21142 - 2.8.1.12 0.00000000000000000000000000226 117.0
TLS2_k127_6149617_62 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000581 117.0
TLS2_k127_6149617_63 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000007625 113.0
TLS2_k127_6149617_64 RNA polymerase sigma factor K03088 - - 0.000000000000000000008455 100.0
TLS2_k127_6149617_65 Preprotein translocase SecG subunit K03075 - - 0.0000000000000000883 85.0
TLS2_k127_6149617_66 structural constituent of ribosome K02911 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000001145 78.0
TLS2_k127_6149617_67 Lysylphosphatidylglycerol synthase TM region K07027,K20468 - - 0.00000000000004067 84.0
TLS2_k127_6149617_69 ThiS family K03636 - - 0.0000000007394 63.0
TLS2_k127_6149617_7 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 502.0
TLS2_k127_6149617_70 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000003289 66.0
TLS2_k127_6149617_71 Surface antigen - - - 0.0000115 58.0
TLS2_k127_6149617_72 Lipopolysaccharide-assembly, LptC-related - - - 0.00009995 51.0
TLS2_k127_6149617_73 TonB dependent receptor - - - 0.000368 49.0
TLS2_k127_6149617_74 - - - - 0.0003748 51.0
TLS2_k127_6149617_8 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 505.0
TLS2_k127_6149617_9 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 493.0
TLS2_k127_6220811_0 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 396.0
TLS2_k127_6220811_1 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000002724 230.0
TLS2_k127_6220811_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000007538 221.0
TLS2_k127_6240552_0 electron transfer activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 518.0
TLS2_k127_6240552_1 cAMP biosynthetic process K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000063 370.0
TLS2_k127_6240552_2 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000007979 238.0
TLS2_k127_6240552_3 LysM domain - - - 0.0000000000000000000000000000000000000000000000002126 183.0
TLS2_k127_6240552_4 Protein of unknown function (DUF559) - - - 0.0000000000000000000000000000000004032 145.0
TLS2_k127_6240552_5 Transcriptional regulator K07979 - - 0.000000000000000000000000006398 122.0
TLS2_k127_6240552_6 - - - - 0.000000000000002176 91.0
TLS2_k127_6240552_7 - - - - 0.000000000007492 79.0
TLS2_k127_6240552_8 Arylsulfatase K01130 - 3.1.6.1 0.0000004734 52.0
TLS2_k127_6274382_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 9.447e-232 730.0
TLS2_k127_6274382_1 repeat protein - - - 3.503e-215 693.0
TLS2_k127_6274382_2 repeat protein - - - 3.833e-201 655.0
TLS2_k127_6274382_3 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 479.0
TLS2_k127_6274382_4 Part of the ABC transporter complex PstSACB involved in phosphate import - - - 0.000000000000000000000000000000000000000001834 163.0
TLS2_k127_6274382_5 - - - - 0.000000000000000000000000000000000000002775 154.0
TLS2_k127_6314213_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 590.0
TLS2_k127_6314213_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 443.0
TLS2_k127_6314213_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000004292 188.0
TLS2_k127_6314213_11 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000006196 169.0
TLS2_k127_6314213_13 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.00000000000000000000000002922 118.0
TLS2_k127_6314213_14 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000005977 103.0
TLS2_k127_6314213_2 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 438.0
TLS2_k127_6314213_3 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 307.0
TLS2_k127_6314213_4 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 304.0
TLS2_k127_6314213_5 Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate K00674,K05822 - 2.3.1.117,2.3.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000431 273.0
TLS2_k127_6314213_6 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000001848 243.0
TLS2_k127_6314213_7 Dihydrodipicolinate synthetase family - - - 0.000000000000000000000000000000000000000000000000000000000000003654 229.0
TLS2_k127_6314213_8 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000001189 228.0
TLS2_k127_6314213_9 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000001708 216.0
TLS2_k127_6360565_0 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 2.093e-284 896.0
TLS2_k127_6360565_1 ABC transporter transmembrane region K11085 - - 1.146e-215 689.0
TLS2_k127_6360565_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000002201 223.0
TLS2_k127_6360565_11 HD domain K07023 - - 0.000000000000000000000000000000000000000000000000000000000003552 222.0
TLS2_k127_6360565_12 Bacterial transcriptional repressor C-terminal - - - 0.000000000000000000000000000000000000000000000001519 181.0
TLS2_k127_6360565_13 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000002988 158.0
TLS2_k127_6360565_14 Disulphide isomerase - - - 0.0000000000000000000000000000000000000001005 154.0
TLS2_k127_6360565_15 Evidence 5 No homology to any previously reported sequences K07156,K07245,K14166 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000001082 131.0
TLS2_k127_6360565_17 Cupin 2, conserved barrel domain protein - - - 0.00001145 50.0
TLS2_k127_6360565_18 acetyltransferase - - - 0.00002947 55.0
TLS2_k127_6360565_19 Belongs to the 'phage' integrase family - - - 0.0003116 44.0
TLS2_k127_6360565_2 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 332.0
TLS2_k127_6360565_3 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 326.0
TLS2_k127_6360565_4 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 314.0
TLS2_k127_6360565_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 305.0
TLS2_k127_6360565_6 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004811 264.0
TLS2_k127_6360565_7 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000007136 256.0
TLS2_k127_6360565_8 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009104 269.0
TLS2_k127_6360565_9 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0000000000000000000000000000000000000000000000000000000000000000001596 237.0
TLS2_k127_642420_0 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 319.0
TLS2_k127_642420_1 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000001306 226.0
TLS2_k127_642420_2 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000001537 119.0
TLS2_k127_6563987_0 MacB-like periplasmic core domain - - - 1.211e-251 803.0
TLS2_k127_6563987_1 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006373 420.0
TLS2_k127_6563987_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000004219 179.0
TLS2_k127_6563987_3 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000003571 166.0
TLS2_k127_6563987_4 - K01286 - 3.4.16.4 0.00000000000000000000000000000000000000001882 175.0
TLS2_k127_6563987_5 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000009567 136.0
TLS2_k127_6563987_6 Penicillinase repressor - - - 0.0000000000000000000000000005669 117.0
TLS2_k127_6563987_7 CopG antitoxin of type II toxin-antitoxin system - - - 0.0000000000000004815 81.0
TLS2_k127_6593863_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0 1084.0
TLS2_k127_6593863_1 deoxyribose-phosphate aldolase activity K01619 - 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 485.0
TLS2_k127_6593863_10 PFAM thioesterase superfamily K07107 - - 0.00000000000000000000000000000008818 129.0
TLS2_k127_6593863_11 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000003074 107.0
TLS2_k127_6593863_12 Lipopolysaccharide-assembly - - - 0.0000000000000000000706 96.0
TLS2_k127_6593863_13 - - - - 0.000000000002002 70.0
TLS2_k127_6593863_14 - - - - 0.0000000005101 69.0
TLS2_k127_6593863_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 299.0
TLS2_k127_6593863_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 291.0
TLS2_k127_6593863_4 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 293.0
TLS2_k127_6593863_5 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000000000000000003068 201.0
TLS2_k127_6593863_6 PFAM diacylglycerol kinase catalytic region - - - 0.00000000000000000000000000000000000000000000000328 186.0
TLS2_k127_6593863_7 Calcineurin-like phosphoesterase K03269 - 3.6.1.54 0.00000000000000000000000000000000000000000001767 172.0
TLS2_k127_6593863_8 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802 - 5.2.1.8 0.000000000000000000000000000000000000000001683 178.0
TLS2_k127_6593863_9 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000003934 168.0
TLS2_k127_6613846_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1060.0
TLS2_k127_6613846_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.231e-300 938.0
TLS2_k127_6613846_10 HI0933-like protein K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008226 441.0
TLS2_k127_6613846_11 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005997 466.0
TLS2_k127_6613846_12 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 410.0
TLS2_k127_6613846_13 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 393.0
TLS2_k127_6613846_14 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 373.0
TLS2_k127_6613846_15 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008463 352.0
TLS2_k127_6613846_16 peptidase dimerisation domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 347.0
TLS2_k127_6613846_17 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 336.0
TLS2_k127_6613846_18 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 333.0
TLS2_k127_6613846_19 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008695 344.0
TLS2_k127_6613846_2 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 2.423e-256 809.0
TLS2_k127_6613846_20 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 319.0
TLS2_k127_6613846_21 protein required for cytochrome oxidase assembly K02259 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 316.0
TLS2_k127_6613846_22 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 302.0
TLS2_k127_6613846_23 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006912 303.0
TLS2_k127_6613846_24 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 291.0
TLS2_k127_6613846_25 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008162 286.0
TLS2_k127_6613846_26 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005026 271.0
TLS2_k127_6613846_27 Arginase family K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000425 258.0
TLS2_k127_6613846_28 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000003838 256.0
TLS2_k127_6613846_29 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000005808 236.0
TLS2_k127_6613846_3 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 585.0
TLS2_k127_6613846_30 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.00000000000000000000000000000000000000000000000000000000000006884 216.0
TLS2_k127_6613846_31 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000002258 204.0
TLS2_k127_6613846_32 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000002693 191.0
TLS2_k127_6613846_33 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000002891 198.0
TLS2_k127_6613846_34 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000002097 179.0
TLS2_k127_6613846_35 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000001347 180.0
TLS2_k127_6613846_36 PHP-associated - - - 0.00000000000000000000000000000000000000000000486 171.0
TLS2_k127_6613846_37 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000006589 173.0
TLS2_k127_6613846_38 Protein of unknown function (DUF3299) K09950 - - 0.000000000000000000000000000000000000001235 154.0
TLS2_k127_6613846_39 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000000000000000000000000001656 149.0
TLS2_k127_6613846_4 ABC transporter transmembrane region K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 572.0
TLS2_k127_6613846_40 Ferric uptake regulator family K03711 - - 0.000000000000000000000000000000000003466 142.0
TLS2_k127_6613846_42 Thioredoxin-like - - - 0.000000000000000000000000000000000005423 153.0
TLS2_k127_6613846_43 Fibronectin fibrinogen-binding protein - - - 0.0000000000000000000000000000000002519 144.0
TLS2_k127_6613846_44 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000001883 140.0
TLS2_k127_6613846_45 SMART Transcription regulator, AsnC-type K03718,K03719 - - 0.000000000000000000000000000000002225 140.0
TLS2_k127_6613846_46 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000002651 126.0
TLS2_k127_6613846_47 COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family K00484 - 1.5.1.36 0.00000000000000000000008167 103.0
TLS2_k127_6613846_48 polysaccharide export K01991 - - 0.000000000000000000001156 104.0
TLS2_k127_6613846_49 YtxH-like protein - - - 0.000000000000000000002057 99.0
TLS2_k127_6613846_5 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 531.0
TLS2_k127_6613846_50 protein kinase activity - - - 0.0000000000000000000172 103.0
TLS2_k127_6613846_51 - - - - 0.000000000000000001024 91.0
TLS2_k127_6613846_52 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000002937 87.0
TLS2_k127_6613846_53 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.000000000000000006466 91.0
TLS2_k127_6613846_54 SNARE associated Golgi protein - - - 0.000000000000002168 84.0
TLS2_k127_6613846_55 Chain length determinant protein K16692 - - 0.000000000000002272 89.0
TLS2_k127_6613846_56 - - - - 0.0000000000001538 81.0
TLS2_k127_6613846_57 PFAM blue (type 1) copper domain protein - - - 0.000000000001648 76.0
TLS2_k127_6613846_58 Signal transduction histidine kinase - - - 0.00000000006745 74.0
TLS2_k127_6613846_59 - - - - 0.0000000001073 68.0
TLS2_k127_6613846_6 DALR_2 K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 493.0
TLS2_k127_6613846_60 Redoxin - - - 0.0000001217 55.0
TLS2_k127_6613846_61 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000009275 52.0
TLS2_k127_6613846_62 Capsule assembly protein Wzi - - - 0.0005238 52.0
TLS2_k127_6613846_7 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 491.0
TLS2_k127_6613846_8 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 487.0
TLS2_k127_6613846_9 Phosphoglucose isomerase K01810 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 445.0
TLS2_k127_6616284_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 533.0
TLS2_k127_6620361_0 cAMP biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 321.0
TLS2_k127_6620361_1 SERine Proteinase INhibitors K13963 - - 0.0000002959 56.0
TLS2_k127_6643396_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 390.0
TLS2_k127_6643396_1 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000002862 181.0
TLS2_k127_6643396_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000007332 158.0
TLS2_k127_6661724_0 CarboxypepD_reg-like domain - - - 5.005e-261 846.0
TLS2_k127_6661724_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.511e-240 783.0
TLS2_k127_6661724_10 Part of the ABC transporter FtsEX involved in K09811 - - 0.0000000000000000000000000000000000000000000000000000000000001207 226.0
TLS2_k127_6661724_11 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000008665 229.0
TLS2_k127_6661724_12 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000008148 200.0
TLS2_k127_6661724_13 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000008203 195.0
TLS2_k127_6661724_14 Transglycosylase SLT domain - - - 0.00000000000000000000000000000002706 136.0
TLS2_k127_6661724_15 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000003756 127.0
TLS2_k127_6661724_16 PPIC-type PPIASE domain K03769,K03771,K07533 - 5.2.1.8 0.000000000000000000000000007043 125.0
TLS2_k127_6661724_17 - - - - 0.00000000000000000000000001036 123.0
TLS2_k127_6661724_18 translation release factor activity K03265 - - 0.00000000000000000002013 104.0
TLS2_k127_6661724_19 Protein of unknown function (DUF1232) - - - 0.00000000000000002029 93.0
TLS2_k127_6661724_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 4.261e-215 680.0
TLS2_k127_6661724_20 - - - - 0.00000000000001706 79.0
TLS2_k127_6661724_21 Domain of unknown function (DUF4397) - - - 0.00000000000007679 81.0
TLS2_k127_6661724_3 Pfam:SusD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 385.0
TLS2_k127_6661724_4 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009632 297.0
TLS2_k127_6661724_5 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004001 265.0
TLS2_k127_6661724_6 Lytic transglycosylase catalytic K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003606 265.0
TLS2_k127_6661724_7 bacterial-type flagellum-dependent cell motility K01317 - 3.4.21.10 0.000000000000000000000000000000000000000000000000000000000000001566 242.0
TLS2_k127_6661724_8 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000005185 229.0
TLS2_k127_6661724_9 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000009419 238.0
TLS2_k127_6663479_0 Carbamoyltransferase C-terminus K00612 - - 5.76e-321 990.0
TLS2_k127_6663479_1 COGs COG3321 Polyketide synthase modules and related protein - - - 1.275e-289 918.0
TLS2_k127_6663479_10 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 303.0
TLS2_k127_6663479_11 Protein involved in cellulose biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002462 271.0
TLS2_k127_6663479_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000005197 236.0
TLS2_k127_6663479_13 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000008752 233.0
TLS2_k127_6663479_14 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000009194 215.0
TLS2_k127_6663479_15 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K11206,K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000001208 204.0
TLS2_k127_6663479_16 thioesterase involved in non-ribosomal peptide biosynthesis - - - 0.000000000000000000000000000000000000000000000007064 183.0
TLS2_k127_6663479_17 TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated - - - 0.0000000000000000000000000000000000000000000008733 179.0
TLS2_k127_6663479_18 Protein of unknown function (DUF3485) - - - 0.0000000000000000000000000000000000000000000274 180.0
TLS2_k127_6663479_19 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000003633 157.0
TLS2_k127_6663479_2 Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - 2.094e-279 897.0
TLS2_k127_6663479_20 - - - - 0.000000000000000000000000009098 114.0
TLS2_k127_6663479_21 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000006867 106.0
TLS2_k127_6663479_22 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000007358 101.0
TLS2_k127_6663479_23 HDOD domain - - - 0.00000000000000002129 94.0
TLS2_k127_6663479_24 - - - - 0.0000000000000005283 78.0
TLS2_k127_6663479_26 Periplasmic protein involved in polysaccharide export K01991 - - 0.0000000000002855 80.0
TLS2_k127_6663479_27 - - - - 0.0000002538 57.0
TLS2_k127_6663479_3 AMP-binding enzyme - - - 5.47e-259 856.0
TLS2_k127_6663479_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 567.0
TLS2_k127_6663479_5 Linear gramicidin synthase subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 541.0
TLS2_k127_6663479_6 Chain length determinant protein K16554 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 522.0
TLS2_k127_6663479_7 Pfam:HxxPF_rpt - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 460.0
TLS2_k127_6663479_8 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 370.0
TLS2_k127_6663479_9 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008112 313.0
TLS2_k127_6700653_0 SMART alpha amylase, catalytic sub domain K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.0 1384.0
TLS2_k127_6700653_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.623e-292 908.0
TLS2_k127_6700653_10 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 601.0
TLS2_k127_6700653_11 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 515.0
TLS2_k127_6700653_12 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 528.0
TLS2_k127_6700653_13 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 490.0
TLS2_k127_6700653_14 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 478.0
TLS2_k127_6700653_15 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 413.0
TLS2_k127_6700653_16 GIY-YIG type nucleases (URI domain) K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 399.0
TLS2_k127_6700653_17 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 397.0
TLS2_k127_6700653_18 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004259 383.0
TLS2_k127_6700653_19 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000677 361.0
TLS2_k127_6700653_2 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 3.015e-289 898.0
TLS2_k127_6700653_20 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 350.0
TLS2_k127_6700653_21 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 341.0
TLS2_k127_6700653_22 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008263 309.0
TLS2_k127_6700653_23 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 311.0
TLS2_k127_6700653_24 photoreceptor activity K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 312.0
TLS2_k127_6700653_25 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 302.0
TLS2_k127_6700653_26 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006807 286.0
TLS2_k127_6700653_27 Peptidase M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001385 283.0
TLS2_k127_6700653_28 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006665 273.0
TLS2_k127_6700653_29 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003 249.0
TLS2_k127_6700653_3 Belongs to the glycosyl hydrolase 57 family - - - 6.274e-289 909.0
TLS2_k127_6700653_30 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000001198 249.0
TLS2_k127_6700653_31 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000001877 239.0
TLS2_k127_6700653_32 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000004175 240.0
TLS2_k127_6700653_33 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000004923 206.0
TLS2_k127_6700653_34 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000000000445 196.0
TLS2_k127_6700653_35 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000008759 201.0
TLS2_k127_6700653_36 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000003818 194.0
TLS2_k127_6700653_37 membrane K11622 - - 0.00000000000000000000000000000000000000000000009932 180.0
TLS2_k127_6700653_38 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000005283 162.0
TLS2_k127_6700653_39 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000002249 159.0
TLS2_k127_6700653_4 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 4.193e-243 766.0
TLS2_k127_6700653_40 - - - - 0.00000000000000000000000000000001689 137.0
TLS2_k127_6700653_41 PFAM nitrogen-fixing NifU domain protein - - - 0.000000000000000000003162 95.0
TLS2_k127_6700653_42 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000002 95.0
TLS2_k127_6700653_43 Carboxypeptidase regulatory-like domain - - - 0.0000000000000009139 87.0
TLS2_k127_6700653_44 Carboxypeptidase regulatory-like domain - - - 0.00000000000008271 82.0
TLS2_k127_6700653_45 Metallo-beta-lactamase superfamily - - - 0.0000000000001217 83.0
TLS2_k127_6700653_46 - - - - 0.00000000000386 74.0
TLS2_k127_6700653_47 - - - - 0.00000001388 64.0
TLS2_k127_6700653_48 - - - - 0.000001661 60.0
TLS2_k127_6700653_5 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 9.18e-235 747.0
TLS2_k127_6700653_6 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K16881 - 2.7.7.13,5.4.2.8 5.423e-228 734.0
TLS2_k127_6700653_7 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 1.808e-217 685.0
TLS2_k127_6700653_8 Alpha amylase, catalytic domain K06044 - 5.4.99.15 9.32e-196 638.0
TLS2_k127_6700653_9 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700,K01236 - 2.4.1.18,3.2.1.141 8.512e-195 631.0
TLS2_k127_6758255_0 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 340.0
TLS2_k127_6758255_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000545 200.0
TLS2_k127_6758255_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K21062 - 3.5.4.22 0.00000000000000000000000000001263 122.0
TLS2_k127_6758255_3 - - - - 0.0000000000000531 82.0
TLS2_k127_6810821_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 567.0
TLS2_k127_6810821_1 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 559.0
TLS2_k127_6810821_10 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.00000000000000000000000000000000000000000009635 169.0
TLS2_k127_6810821_11 Amidohydrolase K03392 - 4.1.1.45 0.0000000007658 61.0
TLS2_k127_6810821_2 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 468.0
TLS2_k127_6810821_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 433.0
TLS2_k127_6810821_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 419.0
TLS2_k127_6810821_5 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 401.0
TLS2_k127_6810821_6 Trypsin K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007261 346.0
TLS2_k127_6810821_7 serine-type endopeptidase activity K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003636 276.0
TLS2_k127_6810821_8 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002739 278.0
TLS2_k127_6810821_9 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000677 189.0
TLS2_k127_6822196_0 protein conserved in bacteria K07793 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 583.0
TLS2_k127_6822196_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 352.0
TLS2_k127_6822196_2 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 348.0
TLS2_k127_6822196_3 Leucyl aminopeptidase (Aminopeptidase t) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 320.0
TLS2_k127_6822196_4 Dihydrodipicolinate synthetase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006054 247.0
TLS2_k127_6822196_5 Bacterial PH domain K08981 - - 0.00000000000000000000000000000000000000000000000000000000003718 224.0
TLS2_k127_6822196_6 Bacterial PH domain K09167 - - 0.00000000000000006242 89.0
TLS2_k127_6822196_7 Tripartite tricarboxylate transporter TctB family - - - 0.00000000001928 71.0
TLS2_k127_6822196_8 PFAM NHL repeat containing protein - - - 0.00002394 56.0
TLS2_k127_6828640_0 WD40-like Beta Propeller Repeat - - - 0.0 1069.0
TLS2_k127_6828640_1 Acetyl xylan esterase (AXE1) - - - 3.605e-310 968.0
TLS2_k127_6828640_10 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 480.0
TLS2_k127_6828640_11 response regulator K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 482.0
TLS2_k127_6828640_12 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 473.0
TLS2_k127_6828640_13 Mur ligase middle domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 423.0
TLS2_k127_6828640_14 PFAM Glycosyl transferase family 2 K10012 - 2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 391.0
TLS2_k127_6828640_15 ATPase activity K06027 - 3.6.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 398.0
TLS2_k127_6828640_16 phosphate transporter K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 381.0
TLS2_k127_6828640_17 PAS domain K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 385.0
TLS2_k127_6828640_18 Type IV pilus assembly protein PilM; K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 362.0
TLS2_k127_6828640_19 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 321.0
TLS2_k127_6828640_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 8.638e-257 819.0
TLS2_k127_6828640_20 AMIN domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009123 329.0
TLS2_k127_6828640_21 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004902 285.0
TLS2_k127_6828640_22 Phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005442 285.0
TLS2_k127_6828640_23 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009887 281.0
TLS2_k127_6828640_24 HTH domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000626 279.0
TLS2_k127_6828640_25 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001394 278.0
TLS2_k127_6828640_26 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000904 252.0
TLS2_k127_6828640_27 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001956 256.0
TLS2_k127_6828640_28 Leishmanolysin - - - 0.0000000000000000000000000000000000000000000000000000000000000000003192 247.0
TLS2_k127_6828640_3 PFAM Circadian clock protein KaiC central region K08482 - - 5.185e-242 756.0
TLS2_k127_6828640_30 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000005123 232.0
TLS2_k127_6828640_31 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000172 219.0
TLS2_k127_6828640_32 histidine kinase, HAMP - - - 0.00000000000000000000000000000000000000000000000000000006772 211.0
TLS2_k127_6828640_33 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000007225 196.0
TLS2_k127_6828640_34 Domain of unknown function (DUF1906) - - - 0.000000000000000000000000000000000000000000000000003206 192.0
TLS2_k127_6828640_35 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000001381 164.0
TLS2_k127_6828640_36 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000005975 151.0
TLS2_k127_6828640_37 Tetratricopeptide repeat protein - - - 0.000000000000000000000000000000000001769 157.0
TLS2_k127_6828640_38 KaiB K08481 - - 0.00000000000000000000000000000000002704 140.0
TLS2_k127_6828640_39 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000000000000000002256 136.0
TLS2_k127_6828640_4 Sodium:alanine symporter family K03310 - - 9.433e-220 696.0
TLS2_k127_6828640_40 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000005411 143.0
TLS2_k127_6828640_41 Transmembrane and TPR repeat-containing protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827 - 0.000000000000000000000000000006107 138.0
TLS2_k127_6828640_42 Tetratricopeptide repeat - - - 0.0000000000000000000000000008466 131.0
TLS2_k127_6828640_43 Fimbrial assembly protein (PilN) - - - 0.00000000000000000000000002348 120.0
TLS2_k127_6828640_44 Domain of unknown function (DUF1736) - - - 0.00000000000000000000000325 119.0
TLS2_k127_6828640_45 helix_turn_helix, Lux Regulon - - - 0.00000000000000000003218 94.0
TLS2_k127_6828640_46 Prokaryotic N-terminal methylation motif - - - 0.000000000000000003969 90.0
TLS2_k127_6828640_47 - - - - 0.0000000001076 70.0
TLS2_k127_6828640_48 Ribosomal protein S21 K02970 - - 0.000000004435 63.0
TLS2_k127_6828640_49 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000809 69.0
TLS2_k127_6828640_5 Sulfate permease family K03321 - - 4.497e-201 640.0
TLS2_k127_6828640_50 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.000000113 63.0
TLS2_k127_6828640_51 Pilus assembly protein PilO K02664 - - 0.0000001179 61.0
TLS2_k127_6828640_52 Type IV pilin-like G and H, putative K02650 - - 0.000000195 59.0
TLS2_k127_6828640_53 - - - - 0.0000003718 62.0
TLS2_k127_6828640_54 protein transport across the cell outer membrane K08084 - - 0.0001221 50.0
TLS2_k127_6828640_55 Pfam:N_methyl_2 - - - 0.0009137 51.0
TLS2_k127_6828640_6 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009312 591.0
TLS2_k127_6828640_7 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 576.0
TLS2_k127_6828640_8 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 520.0
TLS2_k127_6828640_9 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 506.0
TLS2_k127_6840312_0 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009277 579.0
TLS2_k127_6840312_1 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 483.0
TLS2_k127_6840312_10 - - - - 0.000000000000000000000000000000000000000000000000002242 191.0
TLS2_k127_6840312_11 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.00000000000000000000000000000000000000000000000001114 201.0
TLS2_k127_6840312_12 ISXO2-like transposase domain - - - 0.000000000000000000000000000000000005345 149.0
TLS2_k127_6840312_13 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000001311 126.0
TLS2_k127_6840312_14 - - - - 0.00000000000000000000001768 110.0
TLS2_k127_6840312_15 Belongs to the UPF0235 family K09131 - - 0.00000000000000002012 89.0
TLS2_k127_6840312_16 - - - - 0.0000000005971 63.0
TLS2_k127_6840312_17 belongs to the aldehyde dehydrogenase family K03400 - 1.2.1.50 0.00001194 57.0
TLS2_k127_6840312_2 Type II IV secretion system protein K02454,K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 450.0
TLS2_k127_6840312_3 Belongs to the amidase family K19176 - 3.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 361.0
TLS2_k127_6840312_4 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 319.0
TLS2_k127_6840312_5 A G-specific adenine glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005986 277.0
TLS2_k127_6840312_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001979 264.0
TLS2_k127_6840312_7 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000002943 231.0
TLS2_k127_6840312_8 Lytic transglycosylase catalytic K08307 - - 0.0000000000000000000000000000000000000000000000000000000000001259 227.0
TLS2_k127_6840312_9 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate - - - 0.000000000000000000000000000000000000000000000000000001396 203.0
TLS2_k127_6870834_0 Polysaccharide biosynthesis protein K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 464.0
TLS2_k127_6870834_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005848 448.0
TLS2_k127_6870834_10 peptidase S41 - - - 0.00000000000000000000000000000000000000000000000000000000001874 219.0
TLS2_k127_6870834_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000005351 177.0
TLS2_k127_6870834_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000004179 145.0
TLS2_k127_6870834_13 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000007245 147.0
TLS2_k127_6870834_14 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000006085 138.0
TLS2_k127_6870834_15 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000003325 123.0
TLS2_k127_6870834_16 Oxygen tolerance - - - 0.0000000000000000000000000003732 132.0
TLS2_k127_6870834_17 CAAX protease self-immunity K07052 - - 0.00000000000000000000001083 112.0
TLS2_k127_6870834_18 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000005036 56.0
TLS2_k127_6870834_19 - - - - 0.0000177 56.0
TLS2_k127_6870834_2 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 358.0
TLS2_k127_6870834_3 Protein of unknown function (DUF1194) K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008542 333.0
TLS2_k127_6870834_4 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 318.0
TLS2_k127_6870834_5 Beta-lactamase K01453 - 3.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004365 288.0
TLS2_k127_6870834_6 von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000003135 250.0
TLS2_k127_6870834_7 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000003536 225.0
TLS2_k127_6870834_8 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000009503 231.0
TLS2_k127_6870834_9 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000001767 225.0
TLS2_k127_6899006_0 Baseplate J-like protein - - - 8.497e-236 761.0
TLS2_k127_6899006_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 612.0
TLS2_k127_6899006_10 - K06903 - - 0.000000000000000000000000000000000000000001547 164.0
TLS2_k127_6899006_11 Met-10+ like-protein K02687 - - 0.000000000000000000000000000000002311 143.0
TLS2_k127_6899006_12 positive regulation of growth rate - GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896 - 0.000000000000000000000000000000006811 132.0
TLS2_k127_6899006_13 - - - - 0.000000000000000000000000000001943 131.0
TLS2_k127_6899006_14 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000001366 126.0
TLS2_k127_6899006_16 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000007884 68.0
TLS2_k127_6899006_17 COG0500 SAM-dependent methyltransferases - - - 0.000000006054 61.0
TLS2_k127_6899006_18 response to abiotic stimulus K03086,K06867 - - 0.000000009442 61.0
TLS2_k127_6899006_19 N-acetylmuramidase - - - 0.00000008175 63.0
TLS2_k127_6899006_2 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009689 595.0
TLS2_k127_6899006_3 Late control gene D protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 488.0
TLS2_k127_6899006_4 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 502.0
TLS2_k127_6899006_5 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008969 347.0
TLS2_k127_6899006_6 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 289.0
TLS2_k127_6899006_7 Baseplate assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003006 267.0
TLS2_k127_6899006_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000005888 232.0
TLS2_k127_6899006_9 domain, Protein - - - 0.000000000000000000000000000000000000000000000001437 200.0
TLS2_k127_7003406_0 Methionine synthase B12-binding module cap domain protein K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1321.0
TLS2_k127_7003406_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 6.982e-251 789.0
TLS2_k127_7003406_10 Peptidase M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000005702 235.0
TLS2_k127_7003406_11 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000001322 205.0
TLS2_k127_7003406_12 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000009401 154.0
TLS2_k127_7003406_13 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000001833 152.0
TLS2_k127_7003406_14 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000008409 112.0
TLS2_k127_7003406_15 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000002005 109.0
TLS2_k127_7003406_16 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000003143 103.0
TLS2_k127_7003406_17 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000001192 96.0
TLS2_k127_7003406_18 COG0694 Thioredoxin-like proteins and domains - - - 0.00000000000001438 79.0
TLS2_k127_7003406_19 TIGRFAM competence protein ComEA helix-hairpin-helix repeat K02237 - - 0.00000000000005006 80.0
TLS2_k127_7003406_2 Type II secretion system (T2SS), protein E, N-terminal domain K02652 - - 7.064e-226 713.0
TLS2_k127_7003406_20 negative regulation of transcription, DNA-templated K10947 - - 0.0000000000005289 74.0
TLS2_k127_7003406_21 Domain present in PSD-95, Dlg, and ZO-1/2. K04771 - 3.4.21.107 0.00000000001848 75.0
TLS2_k127_7003406_22 - - - - 0.000004751 59.0
TLS2_k127_7003406_3 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008958 602.0
TLS2_k127_7003406_4 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 562.0
TLS2_k127_7003406_5 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005343 501.0
TLS2_k127_7003406_6 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 470.0
TLS2_k127_7003406_7 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 349.0
TLS2_k127_7003406_8 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 310.0
TLS2_k127_7003406_9 Predicted permease YjgP/YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000002457 256.0
TLS2_k127_70206_0 Esterase of the alpha-beta hydrolase superfamily - - - 1.837e-212 702.0
TLS2_k127_70206_1 COGs COG2610 H gluconate symporter and related permease K06156 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 539.0
TLS2_k127_70206_2 TIGRFAM 6-phosphogluconate dehydrogenase (decarboxylating) K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 381.0
TLS2_k127_70206_3 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 324.0
TLS2_k127_70206_4 abc-type fe3 -hydroxamate transport system, periplasmic component - - - 0.0000004852 53.0
TLS2_k127_7042893_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 5.467e-314 985.0
TLS2_k127_7042893_1 HELICc2 K03722 - 3.6.4.12 4.903e-244 781.0
TLS2_k127_7042893_10 Beta-lactamase K01256,K17836 - 3.4.11.2,3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 306.0
TLS2_k127_7042893_11 Domain of unknown function (DUF4159) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 296.0
TLS2_k127_7042893_12 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001557 295.0
TLS2_k127_7042893_13 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000434 266.0
TLS2_k127_7042893_14 Domain of unknown function (DUF2437) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001102 259.0
TLS2_k127_7042893_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000008488 224.0
TLS2_k127_7042893_16 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000001549 209.0
TLS2_k127_7042893_17 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000009377 185.0
TLS2_k127_7042893_18 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000006392 167.0
TLS2_k127_7042893_19 HAD-hyrolase-like K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000004391 167.0
TLS2_k127_7042893_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 514.0
TLS2_k127_7042893_20 Iron-sulphur cluster biosynthesis - - - 0.00000000000000000000000000000000000000000026 162.0
TLS2_k127_7042893_21 Bacterial Ig-like domain - - - 0.000000000000000000000000003083 125.0
TLS2_k127_7042893_22 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division K20543 - - 0.0000000000000001343 94.0
TLS2_k127_7042893_23 BON domain - - - 0.0000000001486 69.0
TLS2_k127_7042893_24 - - - - 0.000007421 57.0
TLS2_k127_7042893_3 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007317 519.0
TLS2_k127_7042893_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 502.0
TLS2_k127_7042893_5 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 457.0
TLS2_k127_7042893_6 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 458.0
TLS2_k127_7042893_7 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 390.0
TLS2_k127_7042893_8 GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002593 369.0
TLS2_k127_7042893_9 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 322.0
TLS2_k127_7101510_0 Solute carrier family 12 - - - 9.211e-302 943.0
TLS2_k127_7101510_1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261,K00262 - 1.4.1.3,1.4.1.4 2.462e-226 720.0
TLS2_k127_7101510_10 Belongs to the ABC transporter superfamily K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007291 332.0
TLS2_k127_7101510_11 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 314.0
TLS2_k127_7101510_12 TIGRFAM molybdate ABC transporter, inner membrane subunit K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000001076 241.0
TLS2_k127_7101510_13 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000001715 214.0
TLS2_k127_7101510_14 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000002834 195.0
TLS2_k127_7101510_15 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000003671 172.0
TLS2_k127_7101510_16 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000008743 133.0
TLS2_k127_7101510_17 - - - - 0.0000000000000000000000000000009 130.0
TLS2_k127_7101510_18 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000006789 122.0
TLS2_k127_7101510_19 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.00000000000000000000000001124 117.0
TLS2_k127_7101510_2 receptor K16091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 604.0
TLS2_k127_7101510_21 DUF218 domain - - - 0.000000002782 70.0
TLS2_k127_7101510_22 - - - - 0.00000001343 66.0
TLS2_k127_7101510_3 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 527.0
TLS2_k127_7101510_4 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 496.0
TLS2_k127_7101510_5 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 486.0
TLS2_k127_7101510_6 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 479.0
TLS2_k127_7101510_7 Aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 434.0
TLS2_k127_7101510_8 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 410.0
TLS2_k127_7154498_0 Outer membrane protein beta-barrel family - - - 1.936e-257 818.0
TLS2_k127_7154498_1 PFAM TonB-dependent Receptor Plug Domain - - - 1.718e-241 784.0
TLS2_k127_7154498_10 Transglycosylase K21464 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 472.0
TLS2_k127_7154498_11 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 448.0
TLS2_k127_7154498_12 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 456.0
TLS2_k127_7154498_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000504 452.0
TLS2_k127_7154498_14 belongs to the sigma-70 factor family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 449.0
TLS2_k127_7154498_15 tRNA-splicing ligase RtcB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 420.0
TLS2_k127_7154498_16 Saccharopine dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 372.0
TLS2_k127_7154498_17 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 363.0
TLS2_k127_7154498_18 Glyco_18 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 340.0
TLS2_k127_7154498_19 oxidoreductase activity, acting on CH-OH group of donors K00034 - 1.1.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 314.0
TLS2_k127_7154498_2 prolyl oligopeptidase K01322 - 3.4.21.26 2.46e-235 747.0
TLS2_k127_7154498_20 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 289.0
TLS2_k127_7154498_21 PD-(D/E)XK nuclease superfamily K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001445 309.0
TLS2_k127_7154498_22 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000476 271.0
TLS2_k127_7154498_23 SusD family K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001468 267.0
TLS2_k127_7154498_24 Domain of unknown function (DUF4159) - - - 0.0000000000000000000000000000000000000000000000000000000002844 219.0
TLS2_k127_7154498_25 56kDa selenium binding protein (SBP56) K17285 - - 0.0000000000000000000000000000000000000000000000000000106 190.0
TLS2_k127_7154498_26 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000001021 179.0
TLS2_k127_7154498_27 DinB family - - - 0.000000000000000000000000000000000000000000000009919 178.0
TLS2_k127_7154498_28 Low temperature requirement - - - 0.00000000000000000000000000000000000000000000002257 191.0
TLS2_k127_7154498_29 DNA-templated transcription, initiation K02405 - - 0.0000000000000000000000000000000000000000000005329 176.0
TLS2_k127_7154498_3 efflux transmembrane transporter activity K02004 - - 1.087e-234 755.0
TLS2_k127_7154498_30 regulation of single-species biofilm formation K13572,K13573 - - 0.00000000000000000000000000000000000000000000262 178.0
TLS2_k127_7154498_31 amine dehydrogenase activity K17285 - - 0.00000000000000000000000000000000000000008008 154.0
TLS2_k127_7154498_32 Transcriptional regulator - - - 0.000000000000000000000000000000000000002912 154.0
TLS2_k127_7154498_33 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000001915 160.0
TLS2_k127_7154498_34 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000002034 147.0
TLS2_k127_7154498_35 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000001135 161.0
TLS2_k127_7154498_36 - - - - 0.000000000000000000000000000000002955 137.0
TLS2_k127_7154498_37 secondary active sulfate transmembrane transporter activity - - - 0.00000000000000000000000000000003875 135.0
TLS2_k127_7154498_38 - - - - 0.0000000000000000000000000000001958 141.0
TLS2_k127_7154498_39 regulation of single-species biofilm formation K13572,K13573 - - 0.000000000000000000000000001282 126.0
TLS2_k127_7154498_4 Belongs to the citrate synthase family K01647 - 2.3.3.1 7.237e-200 630.0
TLS2_k127_7154498_40 Putative restriction endonuclease - - - 0.000000000000000000000000001948 118.0
TLS2_k127_7154498_41 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000000742 122.0
TLS2_k127_7154498_42 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000237 108.0
TLS2_k127_7154498_43 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000000000002723 100.0
TLS2_k127_7154498_44 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000001306 115.0
TLS2_k127_7154498_45 - - - - 0.00000000000000000006373 99.0
TLS2_k127_7154498_46 - - - - 0.00000000000000001072 96.0
TLS2_k127_7154498_47 glyoxalase III activity - - - 0.00000000000000001164 96.0
TLS2_k127_7154498_49 - - - - 0.00000000000000009053 87.0
TLS2_k127_7154498_5 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 597.0
TLS2_k127_7154498_50 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000001447 81.0
TLS2_k127_7154498_52 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000002515 83.0
TLS2_k127_7154498_53 O-methyltransferase - - - 0.00000000000002704 85.0
TLS2_k127_7154498_54 Large family of predicted nucleotide-binding domains - - - 0.000000000006092 72.0
TLS2_k127_7154498_55 NHL repeat - - - 0.0000004014 63.0
TLS2_k127_7154498_56 - - - - 0.000001693 57.0
TLS2_k127_7154498_57 56kDa selenium binding protein (SBP56) K17285 - - 0.00006177 53.0
TLS2_k127_7154498_58 Bacterial Ig-like domain (group 2) - - - 0.00006409 51.0
TLS2_k127_7154498_59 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex - - - 0.0002409 53.0
TLS2_k127_7154498_6 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 592.0
TLS2_k127_7154498_7 Glycosyl hydrolase family 20, domain 2 K12373 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 589.0
TLS2_k127_7154498_8 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 539.0
TLS2_k127_7154498_9 alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 509.0
TLS2_k127_7160292_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.731e-270 849.0
TLS2_k127_7160292_1 Insulinase (Peptidase family M16) K07263 - - 1.366e-237 767.0
TLS2_k127_7160292_10 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 401.0
TLS2_k127_7160292_11 Sodium:dicarboxylate symporter family K03309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 385.0
TLS2_k127_7160292_12 ferredoxin-NADP+ reductase activity K21567 GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 347.0
TLS2_k127_7160292_13 Sodium:dicarboxylate symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 347.0
TLS2_k127_7160292_14 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008447 347.0
TLS2_k127_7160292_15 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 344.0
TLS2_k127_7160292_16 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 307.0
TLS2_k127_7160292_17 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 298.0
TLS2_k127_7160292_18 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 295.0
TLS2_k127_7160292_19 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 291.0
TLS2_k127_7160292_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K02887,K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 602.0
TLS2_k127_7160292_20 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001545 280.0
TLS2_k127_7160292_21 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001471 280.0
TLS2_k127_7160292_22 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002883 285.0
TLS2_k127_7160292_23 - - - - 0.00000000000000000000000000000000000000000000000000000000000000007848 237.0
TLS2_k127_7160292_24 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000967 226.0
TLS2_k127_7160292_25 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000002195 234.0
TLS2_k127_7160292_26 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000000000000000000000002901 223.0
TLS2_k127_7160292_27 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000002519 228.0
TLS2_k127_7160292_28 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000038 218.0
TLS2_k127_7160292_29 KR domain - - - 0.00000000000000000000000000000000000000000000000000275 190.0
TLS2_k127_7160292_3 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 551.0
TLS2_k127_7160292_30 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000004295 185.0
TLS2_k127_7160292_31 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000001633 175.0
TLS2_k127_7160292_32 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000000001528 178.0
TLS2_k127_7160292_33 NUDIX domain - - - 0.0000000000000000000000000000000000000000002459 164.0
TLS2_k127_7160292_34 ferroxidase activity K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.000000000000000000000000000000000000000004677 158.0
TLS2_k127_7160292_35 MlaD protein K02067 - - 0.000000000000000000000000000000000000000007918 166.0
TLS2_k127_7160292_36 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000003887 158.0
TLS2_k127_7160292_37 Protein of unknown function (DUF445) - - - 0.000000000000000000000000000000000000003293 164.0
TLS2_k127_7160292_38 Tetratricopeptide repeat - - - 0.000000000000000000000000000000007095 132.0
TLS2_k127_7160292_39 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000001288 123.0
TLS2_k127_7160292_4 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 521.0
TLS2_k127_7160292_40 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000000000234 123.0
TLS2_k127_7160292_41 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000002809 119.0
TLS2_k127_7160292_42 EVE domain - - - 0.0000000000000000000000001023 111.0
TLS2_k127_7160292_43 Protein of unknown function (DUF721) - - - 0.00000000000000002928 86.0
TLS2_k127_7160292_44 - - - - 0.00000000000000004794 90.0
TLS2_k127_7160292_45 NUDIX domain - - - 0.00000000000000005763 87.0
TLS2_k127_7160292_46 PFAM peptidase - - - 0.0000000000000003358 93.0
TLS2_k127_7160292_47 OsmC-like protein K07397 - - 0.00000000000000449 80.0
TLS2_k127_7160292_48 Thioesterase superfamily - - - 0.000000000000155 79.0
TLS2_k127_7160292_49 - - - - 0.00000000004007 71.0
TLS2_k127_7160292_5 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 497.0
TLS2_k127_7160292_50 COG0457 FOG TPR repeat - - - 0.0000000002393 72.0
TLS2_k127_7160292_51 PFAM Mammalian cell entry related domain protein K02067 - - 0.0000000006219 70.0
TLS2_k127_7160292_52 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000003071 65.0
TLS2_k127_7160292_53 Protein conserved in bacteria - - - 0.00000008807 61.0
TLS2_k127_7160292_54 PFAM Two component regulator propeller - - - 0.0000102 59.0
TLS2_k127_7160292_55 helix_turn_helix, Arsenical Resistance Operon Repressor K22043 - - 0.00001259 55.0
TLS2_k127_7160292_56 - - - - 0.0001707 49.0
TLS2_k127_7160292_57 PRC-barrel domain - - - 0.000203 53.0
TLS2_k127_7160292_6 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 493.0
TLS2_k127_7160292_7 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007628 477.0
TLS2_k127_7160292_8 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006839 459.0
TLS2_k127_7160292_9 Putative ATP-binding cassette K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 455.0
TLS2_k127_7234678_0 DEAD DEAH box K03724 - - 0.0 1659.0
TLS2_k127_7234678_1 MacB-like periplasmic core domain - - - 2e-323 1009.0
TLS2_k127_7234678_10 Xaa-Pro aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 528.0
TLS2_k127_7234678_11 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 516.0
TLS2_k127_7234678_12 Glycosyl hydrolase-like 10 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 514.0
TLS2_k127_7234678_13 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 498.0
TLS2_k127_7234678_14 Multicopper oxidase K22348 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 463.0
TLS2_k127_7234678_15 Domain of unknown function (DUF3471) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 452.0
TLS2_k127_7234678_16 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 441.0
TLS2_k127_7234678_17 PFAM Na Pi-cotransporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 405.0
TLS2_k127_7234678_18 Protein conserved in bacteria K01446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 385.0
TLS2_k127_7234678_19 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 364.0
TLS2_k127_7234678_2 Peptidase dimerisation domain K12941 - - 8.147e-235 736.0
TLS2_k127_7234678_20 antiporter K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 347.0
TLS2_k127_7234678_21 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 344.0
TLS2_k127_7234678_22 Reversible hydration of carbon dioxide K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000006571 257.0
TLS2_k127_7234678_23 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003152 271.0
TLS2_k127_7234678_24 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000001238 254.0
TLS2_k127_7234678_25 ABC transporter, substratebinding protein K02035 - - 0.00000000000000000000000000000000000000000000000000000000001223 229.0
TLS2_k127_7234678_26 Belongs to the FPG family K05522 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000001667 208.0
TLS2_k127_7234678_28 Domain of unknown function (DUF305) - - - 0.000000000000000000000000000000000000935 158.0
TLS2_k127_7234678_29 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000004884 145.0
TLS2_k127_7234678_3 repeat protein - - - 7.482e-221 699.0
TLS2_k127_7234678_30 acetyltransferase involved in intracellular survival and related - - - 0.000000000000000000000000000005658 134.0
TLS2_k127_7234678_31 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000004339 131.0
TLS2_k127_7234678_32 - - - - 0.00000000000000000000001886 107.0
TLS2_k127_7234678_33 Winged helix DNA-binding domain - - - 0.0000000000000000000001687 109.0
TLS2_k127_7234678_34 Dodecin - - - 0.00000000000000000009413 91.0
TLS2_k127_7234678_35 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000000000000423 102.0
TLS2_k127_7234678_36 Lysin motif - - - 0.00000000000000004544 89.0
TLS2_k127_7234678_37 Sigma-70 region 2 K03088 - - 0.0000000000000002415 90.0
TLS2_k127_7234678_38 PAS fold - - - 0.0000000000001026 79.0
TLS2_k127_7234678_39 denitrification pathway - - - 0.00000000006499 75.0
TLS2_k127_7234678_4 protein-glutamate methylesterase K00575,K13924 - 2.1.1.80,3.1.1.61 1.154e-220 726.0
TLS2_k127_7234678_40 BetI-type transcriptional repressor, C-terminal - - - 0.000000007842 66.0
TLS2_k127_7234678_41 TonB-dependent receptor - - - 0.00000002092 68.0
TLS2_k127_7234678_42 Type IV pilus biogenesis stability protein PilW - - - 0.000003599 55.0
TLS2_k127_7234678_43 - - - - 0.0002592 49.0
TLS2_k127_7234678_5 Penicillin amidase K07116 - 3.5.1.97 6.382e-208 670.0
TLS2_k127_7234678_6 Amidohydrolase family K06015 - 3.5.1.81 9.184e-207 657.0
TLS2_k127_7234678_7 Na+/H+ antiporter family - - - 1.202e-206 656.0
TLS2_k127_7234678_8 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 601.0
TLS2_k127_7234678_9 Peptidase dimerisation domain K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 531.0
TLS2_k127_7260163_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 1.981e-295 923.0
TLS2_k127_7260163_1 domain, Protein - - - 4.307e-295 937.0
TLS2_k127_7260163_10 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 453.0
TLS2_k127_7260163_11 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 445.0
TLS2_k127_7260163_12 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 434.0
TLS2_k127_7260163_13 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 404.0
TLS2_k127_7260163_14 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 400.0
TLS2_k127_7260163_15 PFAM amino acid permease-associated region K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 374.0
TLS2_k127_7260163_16 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 359.0
TLS2_k127_7260163_17 Proto-chlorophyllide reductase 57 kD subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 344.0
TLS2_k127_7260163_18 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002628 293.0
TLS2_k127_7260163_19 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002823 284.0
TLS2_k127_7260163_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 8.163e-210 670.0
TLS2_k127_7260163_20 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000001742 263.0
TLS2_k127_7260163_21 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002459 258.0
TLS2_k127_7260163_22 rubredoxin K22405 - 1.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000004652 272.0
TLS2_k127_7260163_23 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007106 251.0
TLS2_k127_7260163_24 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000009913 235.0
TLS2_k127_7260163_25 ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000003771 217.0
TLS2_k127_7260163_26 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000711 209.0
TLS2_k127_7260163_27 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000003966 196.0
TLS2_k127_7260163_28 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000001167 198.0
TLS2_k127_7260163_29 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000008261 200.0
TLS2_k127_7260163_3 isocitrate dehydrogenase activity K00031 GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 586.0
TLS2_k127_7260163_30 protein tyrosine kinase activity K03593 - - 0.000000000000000000000000000000000000000000000000005224 201.0
TLS2_k127_7260163_31 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000001955 189.0
TLS2_k127_7260163_32 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000002794 186.0
TLS2_k127_7260163_33 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000003343 191.0
TLS2_k127_7260163_34 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.00000000000000000000000000000000000000000002756 168.0
TLS2_k127_7260163_35 - - - - 0.00000000000000000000000000000000000000000007866 164.0
TLS2_k127_7260163_36 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000003879 162.0
TLS2_k127_7260163_37 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000001824 155.0
TLS2_k127_7260163_38 protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain - - - 0.0000000000000000000000000000000000001842 154.0
TLS2_k127_7260163_39 Telomere recombination K07566 - 2.7.7.87 0.000000000000000000000000000000007 139.0
TLS2_k127_7260163_4 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 540.0
TLS2_k127_7260163_40 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000007247 133.0
TLS2_k127_7260163_42 Phosphoribosyl transferase domain - - - 0.000000000000000000000000001256 124.0
TLS2_k127_7260163_43 - - - - 0.00000000000000000000002055 113.0
TLS2_k127_7260163_45 - - - - 0.000000000000000006792 91.0
TLS2_k127_7260163_47 Transport permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000005292 87.0
TLS2_k127_7260163_48 Chorismate mutase K00661,K04092,K04093,K04516,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.3.1.79,4.2.1.51,5.4.99.5 0.000000000000001047 80.0
TLS2_k127_7260163_49 TonB-dependent Receptor Plug Domain - - - 0.000000000001056 81.0
TLS2_k127_7260163_5 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 542.0
TLS2_k127_7260163_50 4Fe-4S single cluster domain of Ferredoxin I - - - 0.00000000001551 68.0
TLS2_k127_7260163_51 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.0000000002287 63.0
TLS2_k127_7260163_53 lyase activity - - - 0.00007341 54.0
TLS2_k127_7260163_54 Domain of unknown function (DUF4142) K08995 - - 0.0005335 50.0
TLS2_k127_7260163_6 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005975 521.0
TLS2_k127_7260163_7 TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 479.0
TLS2_k127_7260163_8 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 463.0
TLS2_k127_7260163_9 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 462.0
TLS2_k127_7338135_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1174.0
TLS2_k127_7338135_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.352e-300 933.0
TLS2_k127_7338135_10 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 320.0
TLS2_k127_7338135_11 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 316.0
TLS2_k127_7338135_12 Chain length determinant protein K16692 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 314.0
TLS2_k127_7338135_13 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003527 282.0
TLS2_k127_7338135_14 transferase activity, transferring glycosyl groups K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005102 303.0
TLS2_k127_7338135_15 polysaccharide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006207 280.0
TLS2_k127_7338135_16 PFAM regulator of chromosome condensation, RCC1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005392 258.0
TLS2_k127_7338135_17 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001392 253.0
TLS2_k127_7338135_18 Sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000006352 243.0
TLS2_k127_7338135_19 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000001575 241.0
TLS2_k127_7338135_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.99e-271 854.0
TLS2_k127_7338135_20 Capsule assembly protein Wzi - - - 0.0000000000000000000000000000000000000000000000000000000000000001216 244.0
TLS2_k127_7338135_21 Capsule assembly protein Wzi - - - 0.0000000000000000000000000000000000000000000000000000000000000004324 241.0
TLS2_k127_7338135_22 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000000000000000000000000003923 222.0
TLS2_k127_7338135_23 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000088 206.0
TLS2_k127_7338135_24 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000001113 226.0
TLS2_k127_7338135_25 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000002693 191.0
TLS2_k127_7338135_26 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000001326 195.0
TLS2_k127_7338135_27 Glycosyl transferase, family 2 K07011 - - 0.000000000000000000000000000000000000000000000009051 186.0
TLS2_k127_7338135_28 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000003184 177.0
TLS2_k127_7338135_29 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000001415 164.0
TLS2_k127_7338135_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 565.0
TLS2_k127_7338135_30 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000007153 168.0
TLS2_k127_7338135_31 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000009746 170.0
TLS2_k127_7338135_32 OmpA family K03640 - - 0.0000000000000000000000000000000000001936 150.0
TLS2_k127_7338135_33 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.000000000000000000000000000000001702 139.0
TLS2_k127_7338135_34 structural constituent of ribosome K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000222 133.0
TLS2_k127_7338135_35 TPR repeat - - - 0.000000000000000000000000000000007011 136.0
TLS2_k127_7338135_36 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000002649 139.0
TLS2_k127_7338135_37 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000000001148 131.0
TLS2_k127_7338135_38 polysaccharide export K01991 - - 0.000000000000000000000000000002204 132.0
TLS2_k127_7338135_39 Transcription termination factor nusG K02601,K05785 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000002918 124.0
TLS2_k127_7338135_4 UDP binding domain K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 539.0
TLS2_k127_7338135_40 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000005319 118.0
TLS2_k127_7338135_41 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925,K07102 - 2.7.1.221 0.0000000000000000000000004888 110.0
TLS2_k127_7338135_42 Glycoprotease family K01409,K14742 - 2.3.1.234 0.00000000000000000000000615 110.0
TLS2_k127_7338135_43 PFAM Cytochrome c assembly protein - - - 0.00000000000000000000003407 110.0
TLS2_k127_7338135_44 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000000000000000003431 104.0
TLS2_k127_7338135_45 TonB C terminal K03832 - - 0.00000000000000000003926 100.0
TLS2_k127_7338135_46 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000005197 99.0
TLS2_k127_7338135_47 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000001083 82.0
TLS2_k127_7338135_48 positive regulation of growth rate - - - 0.000000000000002028 89.0
TLS2_k127_7338135_49 PFAM GGDEF domain containing protein - - - 0.0000009545 60.0
TLS2_k127_7338135_5 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008504 501.0
TLS2_k127_7338135_50 O-Antigen ligase - - - 0.000003177 60.0
TLS2_k127_7338135_51 Outer membrane lipoprotein - - - 0.00003142 55.0
TLS2_k127_7338135_6 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K01710,K02377 - 1.1.1.271,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000913 499.0
TLS2_k127_7338135_7 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 432.0
TLS2_k127_7338135_8 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 418.0
TLS2_k127_7338135_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 374.0
TLS2_k127_758165_0 Sulfate permease family K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006415 514.0
TLS2_k127_758165_1 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 409.0
TLS2_k127_758165_2 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 393.0
TLS2_k127_758165_3 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K11422 GO:0000228,GO:0000785,GO:0000790,GO:0000791,GO:0002244,GO:0002376,GO:0002520,GO:0002682,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005700,GO:0005737,GO:0005829,GO:0006325,GO:0006464,GO:0006479,GO:0006807,GO:0006996,GO:0007275,GO:0007568,GO:0008013,GO:0008134,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008340,GO:0008757,GO:0009987,GO:0010259,GO:0016043,GO:0016278,GO:0016279,GO:0016569,GO:0016570,GO:0016571,GO:0016604,GO:0016607,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018024,GO:0018027,GO:0018193,GO:0018205,GO:0019538,GO:0030097,GO:0030154,GO:0031974,GO:0031981,GO:0032259,GO:0032501,GO:0032502,GO:0032991,GO:0033043,GO:0033044,GO:0034708,GO:0034968,GO:0035097,GO:0035327,GO:0036211,GO:0042054,GO:0042800,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044648,GO:0045595,GO:0045637,GO:0045652,GO:0048188,GO:0048513,GO:0048534,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051239,GO:0051276,GO:0051568,GO:0060290,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0080182,GO:0140096,GO:1901532,GO:1901564,GO:1902036,GO:1902275,GO:1902494,GO:1903706,GO:1990234,GO:2000026,GO:2000736 2.1.1.43 0.0000000000000000000000007823 108.0
TLS2_k127_758165_4 cheY-homologous receiver domain - - - 0.0000000000000000000004576 104.0
TLS2_k127_758165_5 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000002067 66.0
TLS2_k127_763001_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 1.844e-212 666.0
TLS2_k127_763001_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 1.168e-210 664.0
TLS2_k127_763001_10 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009675 402.0
TLS2_k127_763001_11 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 392.0
TLS2_k127_763001_12 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 371.0
TLS2_k127_763001_13 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 381.0
TLS2_k127_763001_14 Polyprenyl synthetase K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 363.0
TLS2_k127_763001_15 Amidohydrolase family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 364.0
TLS2_k127_763001_16 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000806 360.0
TLS2_k127_763001_17 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 366.0
TLS2_k127_763001_18 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 347.0
TLS2_k127_763001_19 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 343.0
TLS2_k127_763001_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 4.218e-201 654.0
TLS2_k127_763001_20 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 310.0
TLS2_k127_763001_21 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 318.0
TLS2_k127_763001_22 arginine K01478 - 3.5.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000481 290.0
TLS2_k127_763001_23 Homoserine dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005446 264.0
TLS2_k127_763001_24 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.000000000000000000000000000000000000000000000000000000000000003088 224.0
TLS2_k127_763001_25 PFAM Formiminotransferase domain K00603,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000001509 229.0
TLS2_k127_763001_26 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000003411 233.0
TLS2_k127_763001_27 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000007507 218.0
TLS2_k127_763001_28 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000006758 217.0
TLS2_k127_763001_29 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000000000000001314 207.0
TLS2_k127_763001_3 Ftsk_gamma K03466 - - 4.162e-198 641.0
TLS2_k127_763001_30 DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000000003582 212.0
TLS2_k127_763001_31 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000353 194.0
TLS2_k127_763001_32 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000000004713 184.0
TLS2_k127_763001_33 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000001576 182.0
TLS2_k127_763001_34 Met-10+ like-protein K02687 - - 0.00000000000000000000000000000000000000000000001375 183.0
TLS2_k127_763001_35 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000005121 173.0
TLS2_k127_763001_36 STAS domain K04749 - - 0.0000000000000000000000000000000000000000000004487 180.0
TLS2_k127_763001_37 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000001551 187.0
TLS2_k127_763001_38 Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000000002273 161.0
TLS2_k127_763001_39 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000001209 158.0
TLS2_k127_763001_4 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 516.0
TLS2_k127_763001_40 DNA polymerase III subunit epsilon K02342 - 2.7.7.7 0.000000000000000000000000000000000000001146 158.0
TLS2_k127_763001_41 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000004664 157.0
TLS2_k127_763001_42 Belongs to the ComB family K05979 - 3.1.3.71 0.0000000000000000000000000000000000003896 151.0
TLS2_k127_763001_43 Yqey-like protein K09117 - - 0.0000000000000000000000000000000003627 138.0
TLS2_k127_763001_44 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000004312 141.0
TLS2_k127_763001_45 Binds the 23S rRNA K02909 - - 0.0000000000000000000000001152 111.0
TLS2_k127_763001_46 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.000000000000000000009907 97.0
TLS2_k127_763001_47 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.00000000000000000001325 102.0
TLS2_k127_763001_48 Control of competence regulator ComK, YlbF/YmcA - - - 0.00000000000000000006642 93.0
TLS2_k127_763001_49 membrane transporter protein - - - 0.0000000000000000005043 100.0
TLS2_k127_763001_5 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 504.0
TLS2_k127_763001_51 Zn-ribbon protein, possibly nucleic acid-binding K07164 - - 0.0000000000007076 78.0
TLS2_k127_763001_52 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000002146 70.0
TLS2_k127_763001_53 Domain of unknown function (DUF4321) - - - 0.00000000006944 66.0
TLS2_k127_763001_54 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000000000319 72.0
TLS2_k127_763001_55 His Kinase A (phosphoacceptor) domain - - - 0.0000001289 62.0
TLS2_k127_763001_56 Tetratricopeptide repeat - - - 0.000004879 60.0
TLS2_k127_763001_6 DHH family K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 491.0
TLS2_k127_763001_7 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 429.0
TLS2_k127_763001_8 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 413.0
TLS2_k127_763001_9 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 414.0
TLS2_k127_763520_0 metallocarboxypeptidase activity K14054 - - 4.262e-296 936.0
TLS2_k127_763520_1 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004155 571.0
TLS2_k127_763520_10 Belongs to the UPF0178 family K09768 - - 0.0000000000000000000000000000000000000000000002469 174.0
TLS2_k127_763520_11 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.0000000000000000000000000000000000000000000004569 176.0
TLS2_k127_763520_12 - - - - 0.00000000000000000000000000000000000000002678 156.0
TLS2_k127_763520_13 gag-polyprotein putative aspartyl protease - - - 0.000000000000000000000000000000000000001148 157.0
TLS2_k127_763520_14 Adenylate cyclase - - - 0.0000000000000000000000000000000004061 138.0
TLS2_k127_763520_15 TonB dependent receptor - - - 0.00000000000000000000000005239 126.0
TLS2_k127_763520_16 Sigma-70 region 2 K03088 - - 0.0000000000000000000000006745 109.0
TLS2_k127_763520_18 META domain - - - 0.0000000005444 63.0
TLS2_k127_763520_19 - - - - 0.0000001642 59.0
TLS2_k127_763520_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 512.0
TLS2_k127_763520_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 432.0
TLS2_k127_763520_4 ABC transporter K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 419.0
TLS2_k127_763520_5 COG0842 ABC-type multidrug transport system, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 419.0
TLS2_k127_763520_6 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007293 400.0
TLS2_k127_763520_7 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.0000000000000000000000000000000000000000000000000003858 190.0
TLS2_k127_763520_8 GrpB protein - - - 0.000000000000000000000000000000000000000000000000001602 189.0
TLS2_k127_763520_9 - - - - 0.0000000000000000000000000000000000000000000000269 179.0
TLS2_k127_92419_0 Tricorn protease PDZ domain K08676 - - 0.0 1412.0
TLS2_k127_92419_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 330.0
TLS2_k127_952779_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 9.938e-197 621.0
TLS2_k127_952779_1 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 492.0
TLS2_k127_952779_10 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000002444 173.0
TLS2_k127_952779_11 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000002288 165.0
TLS2_k127_952779_12 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000008086 168.0
TLS2_k127_952779_13 Permease MlaE K02066 - - 0.00000000000000000000000000000000000002109 152.0
TLS2_k127_952779_14 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000748 137.0
TLS2_k127_952779_15 - - - - 0.000000000000000000000000000001222 140.0
TLS2_k127_952779_16 - - - - 0.00000000000000000000000000000186 129.0
TLS2_k127_952779_17 Peptidase family M1 domain K01256 - 3.4.11.2 0.000000000000000000000000000005611 138.0
TLS2_k127_952779_19 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000953 115.0
TLS2_k127_952779_2 Sodium:neurotransmitter symporter family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 464.0
TLS2_k127_952779_20 Zincin-like metallopeptidase - - - 0.0000000000000000000003434 105.0
TLS2_k127_952779_21 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.0000000000000000000004412 109.0
TLS2_k127_952779_22 virulence factor Mce family protein K02067 - - 0.00000000000001788 83.0
TLS2_k127_952779_23 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000225 81.0
TLS2_k127_952779_24 Sugar-specific transcriptional regulator TrmB - - - 0.00000000003448 74.0
TLS2_k127_952779_25 Bacterial regulatory proteins, tetR family - - - 0.000000000392 69.0
TLS2_k127_952779_26 helix_turn_helix, Lux Regulon - - - 0.0000000196 65.0
TLS2_k127_952779_27 Evidence 2b Function of strongly homologous gene - - - 0.0003156 48.0
TLS2_k127_952779_3 DNA polymerase alpha chain like domain K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 455.0
TLS2_k127_952779_4 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 372.0
TLS2_k127_952779_5 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 321.0
TLS2_k127_952779_6 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003456 271.0
TLS2_k127_952779_7 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001521 261.0
TLS2_k127_952779_8 heme binding K08642,K21472 - - 0.00000000000000000000000000000000000000000000000000000000000000000008008 252.0
TLS2_k127_952779_9 PFAM Metal-dependent phosphohydrolase, HD K06951 - - 0.0000000000000000000000000000000000000000000000000000000586 212.0
TLS2_k127_953873_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 471.0
TLS2_k127_953873_1 photoreceptor activity K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006056 402.0
TLS2_k127_953873_2 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 312.0
TLS2_k127_953873_3 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 298.0
TLS2_k127_953873_4 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 302.0
TLS2_k127_953873_5 Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000008628 260.0
TLS2_k127_953873_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002273 258.0
TLS2_k127_953873_7 Domain of unknown function (DUF5117) - - - 0.000000000000000000000000004773 116.0