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Overview

ID MAG04019
Name TLS2_bin.60
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Steroidobacterales
Family Steroidobacteraceae
Genus
Species
Assembly information
Completeness (%) 73.26
Contamination (%) 3.51
GC content (%) 61.0
N50 (bp) 7,047
Genome size (bp) 3,859,843

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3319

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1001895_0 small GTP-binding protein K02355 - - 1.169e-278 872.0
TLS2_k127_1001895_1 Transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000116 152.0
TLS2_k127_1001895_2 COG0784 FOG CheY-like receiver - - - 0.0000000000000000000000000000000000001516 146.0
TLS2_k127_1002808_0 Insecticide toxin TcdB middle/N-terminal region - - - 0.00000000000000000000000000000000000000000000000000001906 206.0
TLS2_k127_1031274_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009498 308.0
TLS2_k127_1031274_1 Domain of unknown function (DUF4252) - - - 0.000000000000000000000000000005428 126.0
TLS2_k127_1031274_2 BON domain - - - 0.00000000000000007545 85.0
TLS2_k127_1043447_0 PFAM Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 478.0
TLS2_k127_1043447_1 Protein of unknown function (DUF1236) - - - 0.00000000000000000000000001279 123.0
TLS2_k127_1069093_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 572.0
TLS2_k127_1069093_1 TIGRFAM FeS assembly SUF system protein SufT - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003293 263.0
TLS2_k127_1069093_2 FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000002269 235.0
TLS2_k127_1069093_3 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000000000000000002142 188.0
TLS2_k127_1090641_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 381.0
TLS2_k127_1090641_1 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000000000000000000002411 211.0
TLS2_k127_1090641_2 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000000001243 123.0
TLS2_k127_1094690_0 ATPases associated with a variety of cellular activities K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 310.0
TLS2_k127_1094690_1 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007339 276.0
TLS2_k127_1094690_2 - K01992 - - 0.0000000000000000000000000000000000000000000000000000000002276 215.0
TLS2_k127_1094690_3 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067,K06192 - - 0.0000000000000000000000000000001056 136.0
TLS2_k127_1100380_0 Belongs to the ClpA ClpB family K03694 - - 0.0 1053.0
TLS2_k127_1100380_1 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 1.952e-202 642.0
TLS2_k127_1100380_2 general secretion pathway protein D K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006308 550.0
TLS2_k127_1100380_3 Type II secretion system protein C - - - 0.0000000000000000000000000000000000000000002553 170.0
TLS2_k127_1100380_4 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000005282 153.0
TLS2_k127_1112778_0 lysine 2,3-aminomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 403.0
TLS2_k127_1112778_1 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 301.0
TLS2_k127_1112778_2 GAF domain K08968 - 1.8.4.14 0.000000000000000000000000000000000000000000000000000000004363 205.0
TLS2_k127_1112778_3 COG2202 FOG PAS PAC domain K21025 - - 0.00000536 54.0
TLS2_k127_1124215_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 452.0
TLS2_k127_1124215_1 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 291.0
TLS2_k127_1124215_2 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000002978 235.0
TLS2_k127_1124215_3 HDOD domain - - - 0.0000000000000000000000000000000000000000000000000007043 194.0
TLS2_k127_1124215_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000006418 169.0
TLS2_k127_1124215_5 Two component signalling adaptor domain K03408 - - 0.00000000002542 65.0
TLS2_k127_1136980_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 581.0
TLS2_k127_1136980_1 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 519.0
TLS2_k127_1136980_10 - - - - 0.0004156 47.0
TLS2_k127_1136980_2 glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 398.0
TLS2_k127_1136980_3 PFAM AsmA family K07289 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 406.0
TLS2_k127_1136980_4 Histidine-specific methyltransferase, SAM-dependent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 331.0
TLS2_k127_1136980_5 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008094 311.0
TLS2_k127_1136980_6 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000003573 245.0
TLS2_k127_1136980_7 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000000000000001745 148.0
TLS2_k127_1136980_8 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000003096 92.0
TLS2_k127_1164488_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 3.723e-198 629.0
TLS2_k127_1164488_1 Pyrimidine nucleoside phosphorylase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 555.0
TLS2_k127_1164488_2 Sodium ABC transporter permease K09696 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 511.0
TLS2_k127_1164488_3 abc transporter atp-binding protein K09697 - 3.6.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 393.0
TLS2_k127_1164488_4 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 326.0
TLS2_k127_1164488_5 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000002322 231.0
TLS2_k127_1164488_6 Helix-turn-helix domain - - - 0.00001145 50.0
TLS2_k127_1164850_0 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 611.0
TLS2_k127_1164850_1 Type II secretion system K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 393.0
TLS2_k127_1164850_2 PFAM type II secretion system protein G K02456 - - 0.000000000000000000000000000000000000000000000000000000639 196.0
TLS2_k127_1164850_3 PFAM General secretion pathway protein K K02460 - - 0.000000000000000000000000000000000000000000000009136 183.0
TLS2_k127_1164850_4 fimbrial assembly K02461 - - 0.00000000000000000000000000000000000006988 157.0
TLS2_k127_1164850_5 General secretion pathway protein H K02457 - - 0.000000000000000000000000000003742 125.0
TLS2_k127_1164850_6 General secretion pathway protein K02459 - - 0.000000000000866 79.0
TLS2_k127_1164850_7 type IV pilus modification protein PilV K02458 - - 0.0000001297 59.0
TLS2_k127_1164850_8 general secretion pathway protein K02462 - - 0.00007521 51.0
TLS2_k127_1169068_0 COG1472 Beta-glucosidase-related glycosidases K05349 - 3.2.1.21 9.539e-302 947.0
TLS2_k127_1169068_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 414.0
TLS2_k127_1169068_2 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 392.0
TLS2_k127_1169068_3 Transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000000000000000002255 225.0
TLS2_k127_1169068_4 Protein of unknown function (DUF1318) - - - 0.0000000000000000000000000000000000000000000000000000000000000894 222.0
TLS2_k127_1171333_0 COG4206 Outer membrane cobalamin receptor protein K16092 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 587.0
TLS2_k127_1171333_1 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 303.0
TLS2_k127_1171333_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001253 260.0
TLS2_k127_1171333_3 PFAM LppC K07121 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003809 261.0
TLS2_k127_1171333_4 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000002949 241.0
TLS2_k127_1171333_5 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000000022 118.0
TLS2_k127_1174307_0 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00499,K16319 - 1.14.12.1,1.14.15.7 9.737e-197 619.0
TLS2_k127_1174307_1 Amino acid permease K03294,K03759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 520.0
TLS2_k127_1182019_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 6.899e-246 769.0
TLS2_k127_1182019_1 belongs to the aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 8.552e-212 677.0
TLS2_k127_1182019_2 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007896 609.0
TLS2_k127_1182019_3 Saccharopine dehydrogenase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 449.0
TLS2_k127_1182019_4 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000137 299.0
TLS2_k127_1203885_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008413 463.0
TLS2_k127_1203885_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005741 398.0
TLS2_k127_1203885_2 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 332.0
TLS2_k127_1206829_0 protein methyltransferase activity - - - 8.869e-220 691.0
TLS2_k127_1206829_1 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 612.0
TLS2_k127_1206829_2 - - - - 0.0000000000000000006303 89.0
TLS2_k127_1211529_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1051.0
TLS2_k127_1213812_0 LysR substrate binding domain K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000006482 230.0
TLS2_k127_1213812_1 - - - - 0.000000000000000000007593 96.0
TLS2_k127_1213812_2 Aminotransferase class I and II - - - 0.0000000000003947 70.0
TLS2_k127_1214711_0 PFAM biotin lipoyl attachment domain-containing protein - - - 0.0 1077.0
TLS2_k127_1214711_1 functions in conversion of succinate to propionate K01847 - 5.4.99.2 2.881e-241 758.0
TLS2_k127_1214711_2 PFAM carboxyl transferase - - - 0.00000000000000000000000000000009366 126.0
TLS2_k127_122748_0 PFAM Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 437.0
TLS2_k127_122748_1 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000003877 240.0
TLS2_k127_122748_2 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.00000000000000000000000000000000000000000000000000000001973 203.0
TLS2_k127_122748_3 Monogalactosyldiacylglycerol (MGDG) synthase K03429 - 2.4.1.315 0.000000000000000000000000000000000000000000000000001065 201.0
TLS2_k127_122748_4 proteolysis - - - 0.00000000000000000000000000000000000000000000003314 181.0
TLS2_k127_122748_5 polysaccharide deacetylase - - - 0.00000000000000003302 90.0
TLS2_k127_122748_6 PFAM glycosyl transferase group 1 - - - 0.0000002931 52.0
TLS2_k127_1231853_0 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 506.0
TLS2_k127_1231853_1 enterobactin catabolic process K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 432.0
TLS2_k127_1231853_2 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000004603 250.0
TLS2_k127_1231853_3 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000002728 219.0
TLS2_k127_1231853_4 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000001379 215.0
TLS2_k127_1231853_5 amine dehydrogenase activity - - - 0.0000000000000000000000000004166 121.0
TLS2_k127_1236601_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 3.385e-239 747.0
TLS2_k127_1236601_1 NADP transhydrogenase K00324 - 1.6.1.2 1.395e-196 618.0
TLS2_k127_1236601_2 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 396.0
TLS2_k127_1236601_3 Bacterial lipid A biosynthesis acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 340.0
TLS2_k127_1236601_4 PFAM HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 294.0
TLS2_k127_1236601_5 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000007186 176.0
TLS2_k127_1236601_6 membrane - - - 0.00000000000000000000000000000000000007103 154.0
TLS2_k127_1236601_7 Fatty acyl CoA synthetase - - - 0.0000000000000000000000000000000007914 139.0
TLS2_k127_1236601_8 dehydratase - - - 0.000000000000000007118 87.0
TLS2_k127_1239951_0 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 351.0
TLS2_k127_1239951_1 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000005726 147.0
TLS2_k127_1275720_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 576.0
TLS2_k127_1275720_1 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 413.0
TLS2_k127_1275720_11 Pfam:DUF1049 K08992 - - 0.000006514 53.0
TLS2_k127_1275720_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 381.0
TLS2_k127_1275720_3 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009572 395.0
TLS2_k127_1275720_4 Threonine transporter RhtB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006875 329.0
TLS2_k127_1275720_5 Tryptophan-rich sensory protein K05770 - - 0.00000000000000000000000000000000000000000000000000000000000000002576 226.0
TLS2_k127_1275720_6 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000001593 201.0
TLS2_k127_1275720_7 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000002183 192.0
TLS2_k127_1275720_8 3D domain protein - - - 0.0000000000000000000000000000000001761 137.0
TLS2_k127_1275720_9 Protein of unknown function (DUF559) K07316 - 2.1.1.72 0.0000000000000000000000000000000002153 135.0
TLS2_k127_1285134_0 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 424.0
TLS2_k127_1285134_1 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 347.0
TLS2_k127_1285134_2 Plays a role in the flagellum-specific transport system K02419 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 306.0
TLS2_k127_1285134_3 Role in flagellar biosynthesis K02421 - - 0.00000000000000000000000000000000000000000000000000000000000000004115 231.0
TLS2_k127_1285134_4 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 - - 0.000000000000000000000000000000000000000000009127 164.0
TLS2_k127_1285134_5 Role in flagellar biosynthesis K02420 - - 0.00000000000000000000000000000000872 130.0
TLS2_k127_1285134_6 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.000000000000000000000000000001845 126.0
TLS2_k127_1285134_7 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.00000000000000000009325 89.0
TLS2_k127_1285134_8 PFAM flagellar biosynthesis protein, FliO K02418 - - 0.0000000000001942 80.0
TLS2_k127_128562_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 398.0
TLS2_k127_128562_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 362.0
TLS2_k127_128562_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 334.0
TLS2_k127_128562_3 Domain of unknown function (DUF1993) K09983 - - 0.0000000000000000000000000000000000000000000000000000000000000006625 223.0
TLS2_k127_128562_4 Transcriptional regulator K13572 - - 0.00000000000000000000000000000000000000000000000000000000007019 216.0
TLS2_k127_128562_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000001577 181.0
TLS2_k127_128562_6 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000000000000003814 171.0
TLS2_k127_128562_7 - - - - 0.00000000000000000000000000000000001372 138.0
TLS2_k127_128562_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00005575 51.0
TLS2_k127_131782_0 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 398.0
TLS2_k127_131782_1 helix_turn_helix, Lux Regulon K07689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007162 269.0
TLS2_k127_1323270_0 Glycosyltransferase WbsX - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 384.0
TLS2_k127_1323270_1 Capsule assembly protein Wzi - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005484 280.0
TLS2_k127_1335289_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1206.0
TLS2_k127_1335289_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000734 552.0
TLS2_k127_1335289_2 Response regulator in two-component regulatory system with KdpD K07667 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003398 267.0
TLS2_k127_1335289_3 Histidine kinase K07646 - 2.7.13.3 0.000000000000000000000000841 107.0
TLS2_k127_1339399_0 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 1.194e-253 802.0
TLS2_k127_1339399_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.549e-197 625.0
TLS2_k127_1339399_10 Outer membrane lipoprotein - - - 0.0000000000000000000000000000000000004967 147.0
TLS2_k127_1339399_11 Peptidase propeptide and YPEB domain - - - 0.0007567 47.0
TLS2_k127_1339399_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 601.0
TLS2_k127_1339399_3 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 479.0
TLS2_k127_1339399_4 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 460.0
TLS2_k127_1339399_5 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 332.0
TLS2_k127_1339399_6 MazG family K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009414 311.0
TLS2_k127_1339399_7 Histidine kinase K07637 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002383 293.0
TLS2_k127_1339399_8 NUDIX domain - - - 0.000000000000000000000000000000000000000000002326 172.0
TLS2_k127_1339399_9 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.000000000000000000000000000000000000000000009446 171.0
TLS2_k127_1340629_0 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 585.0
TLS2_k127_1340629_1 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000267 283.0
TLS2_k127_1348045_0 ABC transporter K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000064 247.0
TLS2_k127_1348045_1 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000002854 214.0
TLS2_k127_136773_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.624e-304 944.0
TLS2_k127_1372056_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 2.318e-231 741.0
TLS2_k127_1372056_1 - - - - 0.0000000000000000000000000000000000000000000000000000005909 207.0
TLS2_k127_1372056_2 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000002853 160.0
TLS2_k127_139778_0 Prolyl oligopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007953 280.0
TLS2_k127_139778_1 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000238 159.0
TLS2_k127_139778_2 NmrA-like family - - - 0.00000000000000000000000000002246 124.0
TLS2_k127_1410312_0 Serine hydrolase involved in the detoxification of formaldehyde K01070,K09795 - 3.1.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 408.0
TLS2_k127_1410312_1 transporter K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 315.0
TLS2_k127_1410312_2 OsmC-like protein K07397 - - 0.000000000000000000000000000000000000000000000000000003237 194.0
TLS2_k127_1410312_3 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000000000000001222 194.0
TLS2_k127_1446965_0 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 404.0
TLS2_k127_1446965_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00836 GO:0003674,GO:0003824,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019491,GO:0019752,GO:0032787,GO:0042399,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 332.0
TLS2_k127_1446965_2 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.0000000000000000000000000000000000000000000000000000000003573 205.0
TLS2_k127_1446965_3 Ectoine hydroxyectoine ABC transporter solute-binding protein K02030 - - 0.0000001658 55.0
TLS2_k127_1447429_0 PFAM Pyruvate carboxyltransferase K01640,K18314 - 4.1.3.4,4.1.3.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 359.0
TLS2_k127_1447429_1 Peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000001576 228.0
TLS2_k127_1447429_2 FCD - - - 0.00000000000000000000000000000000000000000000000001452 189.0
TLS2_k127_1447429_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0000000000000000007902 87.0
TLS2_k127_1447429_4 Electron transfer flavoprotein K03522 - - 0.0000000000847 62.0
TLS2_k127_1449456_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 537.0
TLS2_k127_1449456_1 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 381.0
TLS2_k127_1449456_2 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001925 256.0
TLS2_k127_1449456_3 Radical SAM superfamily - - - 0.0000000000000000000000000000000007385 132.0
TLS2_k127_1449456_4 OmpA-like transmembrane domain - - - 0.00000000000000000007842 97.0
TLS2_k127_1459647_0 PFAM helix-turn-helix- domain containing protein, AraC type - - - 0.000000000000000000000000000000000000000000000000000133 199.0
TLS2_k127_1459647_1 YCII-related domain - - - 0.0000000000002133 76.0
TLS2_k127_1466017_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 551.0
TLS2_k127_1466017_1 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 521.0
TLS2_k127_1466017_2 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 420.0
TLS2_k127_1466017_3 PFAM CBS domain K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 317.0
TLS2_k127_1466017_5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000001188 147.0
TLS2_k127_147756_0 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000001053 151.0
TLS2_k127_147756_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000003936 75.0
TLS2_k127_147756_3 Peptidase M56, BlaR1 - - - 0.0002703 51.0
TLS2_k127_1478824_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 547.0
TLS2_k127_1504918_0 TonB-dependent Receptor Plug - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 394.0
TLS2_k127_1525714_0 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007196 281.0
TLS2_k127_1525714_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000009056 200.0
TLS2_k127_1526075_0 Histidine kinase K14986 - 2.7.13.3 0.00000000000000000000000000000000004313 145.0
TLS2_k127_1526075_1 PAS fold - - - 0.0000000000000000000000000002656 122.0
TLS2_k127_1526075_2 DnaK suppressor protein - - - 0.00000000000000425 80.0
TLS2_k127_1536662_0 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 338.0
TLS2_k127_1536662_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000002088 75.0
TLS2_k127_1544414_0 TonB-dependent receptor plug K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 528.0
TLS2_k127_1544414_1 Phenazine biosynthesis protein, PhzF family K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000002378 258.0
TLS2_k127_1544414_2 nicotinamide mononucleotide transporter K03811 - - 0.0000000000000000000000000000000000000000000000000000000002819 210.0
TLS2_k127_1544414_3 YKOF-related Family - - - 0.0000000000000000000001645 98.0
TLS2_k127_15469_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 564.0
TLS2_k127_15469_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 428.0
TLS2_k127_15469_2 cation diffusion facilitator family transporter K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 311.0
TLS2_k127_15469_3 Dolichol-phosphate mannosyltransferase K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000002142 267.0
TLS2_k127_15469_4 Type II transport protein GspH K08084 - - 0.00000004626 58.0
TLS2_k127_1548881_0 HTH-like domain K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 376.0
TLS2_k127_1548881_1 Transposase - - - 0.000000000000000000000000000000000001966 140.0
TLS2_k127_1548881_2 Integrase core domain - - - 0.0005693 43.0
TLS2_k127_1561935_0 Allophanate hydrolase subunit 1 K01941 - 6.3.4.6 4.1e-299 937.0
TLS2_k127_1561935_1 Allophanate hydrolase K01457 - 3.5.1.54 2.126e-216 689.0
TLS2_k127_1565639_0 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 339.0
TLS2_k127_1565639_1 TIGRFAM Urea carboxylase-associated protein 2 K09967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007633 286.0
TLS2_k127_1572033_0 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 8.782e-207 657.0
TLS2_k127_1572033_1 PFAM Glycosyl Hydrolase Family 88 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 430.0
TLS2_k127_1572033_2 Glucose-fructose oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 428.0
TLS2_k127_1572033_3 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000002384 237.0
TLS2_k127_1589460_0 Glycosyl hydrolases family 43 - - - 1.212e-309 960.0
TLS2_k127_1589460_1 Alpha beta hydrolase K15923 - 3.2.1.51 3.441e-292 916.0
TLS2_k127_1589460_2 Protein of unknown function (DUF1415) K09941 - - 0.0000000000000000000000000000000000000000000000000000000001792 211.0
TLS2_k127_159207_0 PFAM aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 482.0
TLS2_k127_159207_1 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 462.0
TLS2_k127_159207_2 Tetrapyrrole (Corrin/Porphyrin) Methylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 397.0
TLS2_k127_159207_4 Acetyltransferase (GNAT) domain - - - 0.000000005147 64.0
TLS2_k127_1636717_0 AcrB/AcrD/AcrF family K18138,K18146 - - 1.317e-294 917.0
TLS2_k127_1640949_0 Cellulase N-terminal ig-like domain - - - 4.136e-241 762.0
TLS2_k127_1640949_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003436 589.0
TLS2_k127_1640949_10 L-rhamnose mutarotase - - - 0.000000000000000000000000000000000000000000007716 165.0
TLS2_k127_1640949_2 RESPONSE REGULATOR receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004059 552.0
TLS2_k127_1640949_3 Major facilitator superfamily K02429 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 544.0
TLS2_k127_1640949_4 Dehydrogenase K00008 GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 460.0
TLS2_k127_1640949_5 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 385.0
TLS2_k127_1640949_6 PFAM Ion transport K08714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 323.0
TLS2_k127_1640949_7 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003006 285.0
TLS2_k127_1640949_8 Alpha-L-fucosidase K01206 - 3.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000002609 237.0
TLS2_k127_1640949_9 Glycosyl hydrolases family 8 K15531 - 3.2.1.156 0.0000000000000000000000000000000000000000000000000000000000000876 213.0
TLS2_k127_1642802_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 330.0
TLS2_k127_1642802_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000007084 129.0
TLS2_k127_1663721_0 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 302.0
TLS2_k127_1663721_1 Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002587 286.0
TLS2_k127_1663721_2 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000000006027 260.0
TLS2_k127_1663721_3 PFAM electron transport protein SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000000006556 174.0
TLS2_k127_1669787_0 Domain related to MnhB subunit of Na+/H+ antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004722 264.0
TLS2_k127_1669787_1 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000000006949 214.0
TLS2_k127_1669787_2 PFAM cation antiporter K05569 - - 0.0000000000000000000000000000005765 129.0
TLS2_k127_1669787_3 PFAM Na H antiporter subunit K05571 - - 0.0000000000000000000000000211 112.0
TLS2_k127_1669787_4 antiporter activity K05570 - - 0.0000000000000000000000004908 107.0
TLS2_k127_1677478_0 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 445.0
TLS2_k127_1677478_1 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000141 219.0
TLS2_k127_1677478_2 COG1309 Transcriptional regulator - - - 0.00000000006874 63.0
TLS2_k127_1684140_0 COG3119 Arylsulfatase A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 346.0
TLS2_k127_1688183_0 DNA-binding domain of Proline dehydrogenase K13821 - 1.2.1.88,1.5.5.2 1.457e-201 646.0
TLS2_k127_1688183_1 XdhC and CoxI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002672 267.0
TLS2_k127_1688183_2 MOSC domain protein beta barrel domain protein K07140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001253 260.0
TLS2_k127_1688183_3 PFAM Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000000000000006005 228.0
TLS2_k127_1688183_4 conserved protein UCP033924 - - - 0.000000000000000000000000000000000000000000000000005255 184.0
TLS2_k127_1688183_5 salt-induced outer membrane protein K07283 - - 0.00000000000000000000000000000000004207 146.0
TLS2_k127_1688183_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000009094 61.0
TLS2_k127_1696041_0 TonB dependent receptor - - - 1.382e-223 715.0
TLS2_k127_1696041_1 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 295.0
TLS2_k127_1696041_2 Domain of unknown function (DUF3526) K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000006823 239.0
TLS2_k127_169856_0 Belongs to the peptidase M16 family K07263 - - 1e-323 1016.0
TLS2_k127_169856_1 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003327 273.0
TLS2_k127_1709562_0 Di-haem oxidoreductase, putative peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 468.0
TLS2_k127_1709562_1 Iron-regulated protein K07231 - - 0.000000000000000000000000000000000000000001016 164.0
TLS2_k127_1709562_2 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000004038 66.0
TLS2_k127_1718880_0 Belongs to the GARS family K01945,K13713 GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 544.0
TLS2_k127_1718880_1 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000001028 220.0
TLS2_k127_1718880_2 - - - - 0.000000002576 62.0
TLS2_k127_1720848_0 long-chain fatty acid transport protein - - - 0.0 1151.0
TLS2_k127_1720848_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K15022 - 1.17.1.10 4.907e-287 893.0
TLS2_k127_1720848_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K01406 - 3.4.24.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 435.0
TLS2_k127_1720848_3 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 394.0
TLS2_k127_1720848_4 TIGRFAM conserved repeat domain - - - 0.0000000000000000000000000000000000000000000000000000166 201.0
TLS2_k127_1720848_5 TIGRFAM conserved repeat domain - - - 0.0000000000000000000000000000000000000000000000003159 192.0
TLS2_k127_1720848_6 - - - - 0.000000000000000000000000000000009853 132.0
TLS2_k127_1747563_0 Belongs to the glycosyl hydrolase 67 family K01235 - 3.2.1.139 0.0 1099.0
TLS2_k127_1747563_1 Mandelate racemase muconate lactonizing enzyme K08323 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575 4.2.1.8 1.476e-237 739.0
TLS2_k127_1747563_2 glucuronate isomerase K01812 - 5.3.1.12 7.639e-228 715.0
TLS2_k127_1747563_3 fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 505.0
TLS2_k127_1747563_4 helix_turn _helix lactose operon repressor K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 497.0
TLS2_k127_1747563_5 PFAM Major Facilitator Superfamily K08191 - - 0.000000000000000000000000000000000000000000000000004077 192.0
TLS2_k127_1749451_0 Molecular chaperone. Has ATPase activity K04079 - - 2.624e-213 673.0
TLS2_k127_1749451_1 PFAM Type II secretion system protein E K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 560.0
TLS2_k127_1749451_11 Domain of unknown function (DUF4426) - - - 0.00000000000000000000000005641 113.0
TLS2_k127_1749451_12 twitching motility protein K02670 - - 0.00000000000213 69.0
TLS2_k127_1749451_2 Aminotransferase class-III K00819,K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.13,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 536.0
TLS2_k127_1749451_3 Phospholipid-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007879 271.0
TLS2_k127_1749451_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000005374 263.0
TLS2_k127_1749451_5 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000007939 242.0
TLS2_k127_1749451_6 X-Pro dipeptidyl-peptidase (S15 family) K07018 - - 0.00000000000000000000000000000000000000000000000000001993 195.0
TLS2_k127_1749451_7 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000000000000004715 158.0
TLS2_k127_1749451_8 integral membrane protein K02221 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000718 125.0
TLS2_k127_1749451_9 Belongs to the bacterial histone-like protein family - - - 0.00000000000000000000000000006043 119.0
TLS2_k127_1751787_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 362.0
TLS2_k127_1751787_1 receptor K16087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 354.0
TLS2_k127_1751787_2 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.0000000000000000000000000000000000000002843 153.0
TLS2_k127_1751787_3 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.0000000000000000000000000000000005696 143.0
TLS2_k127_1751787_4 Flagellar biosynthesis type III secretory pathway chaperone K02399 - - 0.00000003227 61.0
TLS2_k127_1751787_5 Hemin uptake protein hemP - - - 0.0000007898 56.0
TLS2_k127_1751787_6 COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor) K02398 - - 0.000002799 53.0
TLS2_k127_1770138_0 cAMP biosynthetic process K03641,K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 464.0
TLS2_k127_1770138_2 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000002565 109.0
TLS2_k127_1785422_0 Concanavalin A-like lectin/glucanases superfamily - - - 9.062e-228 725.0
TLS2_k127_1785422_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009431 434.0
TLS2_k127_1790298_0 His Kinase A (phosphoacceptor) domain - - - 1.052e-214 687.0
TLS2_k127_1790298_1 SMART AAA ATPase K08482 - - 3.345e-205 646.0
TLS2_k127_1790298_2 membrane-bound metal-dependent K01993,K07038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 382.0
TLS2_k127_1790298_3 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009526 268.0
TLS2_k127_1790298_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001714 235.0
TLS2_k127_1790298_5 protein conserved in bacteria K09793 - - 0.00000000000000000000000000000000000000000000003086 175.0
TLS2_k127_1790298_6 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.00000000000000000000000000000000000000004223 164.0
TLS2_k127_1790298_7 Domain of unknown function (DUF4342) - - - 0.00000000000000006994 83.0
TLS2_k127_1790298_8 Domain of unknown function (DUF4136) - - - 0.000004121 55.0
TLS2_k127_180076_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 534.0
TLS2_k127_180076_1 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005288 359.0
TLS2_k127_1806649_0 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 329.0
TLS2_k127_1806649_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000008466 255.0
TLS2_k127_1806649_2 Thioesterase superfamily K19222 - 3.1.2.28 0.000000000000000000000000000000000000000000000001409 177.0
TLS2_k127_1806649_3 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.000001232 50.0
TLS2_k127_1807083_0 transmembrane transporter activity K18138 - - 0.0 1437.0
TLS2_k127_1807083_1 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 613.0
TLS2_k127_1807083_2 Major Facilitator K08219 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 345.0
TLS2_k127_1807083_3 - - - - 0.000000000000000000000000000000002376 137.0
TLS2_k127_1810589_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1189.0
TLS2_k127_1810589_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 492.0
TLS2_k127_1810589_2 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 432.0
TLS2_k127_1810589_3 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 428.0
TLS2_k127_1810589_4 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 301.0
TLS2_k127_1810589_5 4-phosphoerythronate dehydrogenase activity K00058 - 1.1.1.399,1.1.1.95 0.00000000000004175 73.0
TLS2_k127_1810589_6 Phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000004396 68.0
TLS2_k127_1813735_0 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 573.0
TLS2_k127_1813735_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 511.0
TLS2_k127_1813735_2 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 403.0
TLS2_k127_1813735_3 Protein of unknown function (DUF3450) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003578 270.0
TLS2_k127_1813735_4 MotA/TolQ/ExbB proton channel family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001296 242.0
TLS2_k127_1813735_5 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000000000000000000000000000000000001294 218.0
TLS2_k127_1813735_6 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000000000000000000000002248 181.0
TLS2_k127_1813735_7 Biopolymer transport protein ExbD/TolR K03559 - - 0.0000000000000000000000000000000000000000000000147 174.0
TLS2_k127_1818400_0 diguanylate cyclase - - - 1.111e-257 815.0
TLS2_k127_1818400_1 PFAM OsmC family protein - - - 0.00000000000000000000000000000000000000000000000000000000001116 209.0
TLS2_k127_1818719_0 Putative esterase K07214 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 505.0
TLS2_k127_1818719_1 Cellulase N-terminal ig-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 357.0
TLS2_k127_1818719_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000004496 269.0
TLS2_k127_1818719_3 protein conserved in bacteria K09974 - - 0.00000000000000000000000000000000000000000000000000000000000000002327 238.0
TLS2_k127_1818719_4 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000363 203.0
TLS2_k127_1818719_5 Thioredoxin K03672 - 1.8.1.8 0.000000000000000000000000000000000000000000000000002796 185.0
TLS2_k127_1818719_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000001031 181.0
TLS2_k127_1818719_7 Shikimate kinase K00851 - 2.7.1.12 0.00000000000000000000000000000000000005721 148.0
TLS2_k127_1818719_8 Acetyltransferase (GNAT) domain K03830 - - 0.00000000000000000000000000000000001669 147.0
TLS2_k127_1818719_9 - - - - 0.0000000000000005472 81.0
TLS2_k127_1824240_0 RNA-metabolising metallo-beta-lactamase K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 556.0
TLS2_k127_1824240_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006176 458.0
TLS2_k127_1824240_2 Domain of unknown function (DUF4154) - - - 0.000000000000000000000001435 113.0
TLS2_k127_1824240_3 Domain of unknown function (DUF4154) - - - 0.00000000000000000000006534 106.0
TLS2_k127_1824240_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000002953 96.0
TLS2_k127_1824240_5 Universal stress protein - - - 0.00000000007646 70.0
TLS2_k127_1829933_0 PDZ-like domain - - - 2.185e-210 681.0
TLS2_k127_1829933_1 Belongs to the SUA5 family K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 326.0
TLS2_k127_1848382_0 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 338.0
TLS2_k127_1848382_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 304.0
TLS2_k127_1848382_2 Glycosyl Transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 293.0
TLS2_k127_1848382_3 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000111 178.0
TLS2_k127_1848382_4 Protein of unknown function (DUF3106) - - - 0.0000003536 60.0
TLS2_k127_1848382_5 - - - - 0.0000003863 57.0
TLS2_k127_1852672_0 transferase activity, transferring glycosyl groups K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 579.0
TLS2_k127_1852672_1 UDP binding domain K00066 - 1.1.1.132 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 558.0
TLS2_k127_1852672_2 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 344.0
TLS2_k127_1852672_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 348.0
TLS2_k127_1852672_4 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001712 275.0
TLS2_k127_1852672_5 phosphatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002292 256.0
TLS2_k127_1852672_6 polysaccharide export protein K01991 - - 0.00000000000000000000000000000000000000000000000003569 185.0
TLS2_k127_1852672_7 Belongs to the UPF0145 family - - - 0.0003641 43.0
TLS2_k127_1875553_0 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006715 375.0
TLS2_k127_1875553_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 381.0
TLS2_k127_1875553_2 response regulator K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000001483 243.0
TLS2_k127_1875553_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001072 246.0
TLS2_k127_1875553_4 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 0.0000000000000000000000000000000000000000000000000000001318 198.0
TLS2_k127_1875553_5 alginic acid biosynthetic process - - - 0.000000000000000000000000001787 119.0
TLS2_k127_1875607_0 Belongs to the IlvD Edd family K01690 - 4.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 342.0
TLS2_k127_1875607_1 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247,K13529 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000009253 261.0
TLS2_k127_1875607_2 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000003364 177.0
TLS2_k127_1875607_3 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000005048 144.0
TLS2_k127_1884376_0 Ammonium transporter K03320 - - 1.449e-205 655.0
TLS2_k127_1884376_1 PFAM Magnesium chelatase, ChlI subunit K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 580.0
TLS2_k127_1884376_10 general secretion pathway protein - - - 0.00000006132 53.0
TLS2_k127_1884376_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 502.0
TLS2_k127_1884376_3 Uroporphyrinogen-III synthase HemD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 334.0
TLS2_k127_1884376_4 6-phosphogluconate dehydrogenase, NAD-binding K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009168 302.0
TLS2_k127_1884376_5 Belongs to the P(II) protein family K04751,K04752 - - 0.0000000000000000000000000000000000000000000000000001295 191.0
TLS2_k127_1884376_6 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000001364 149.0
TLS2_k127_1884376_7 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000005333 116.0
TLS2_k127_1884376_8 Transcriptional regulator PadR-like family - - - 0.000000000000000000000006579 105.0
TLS2_k127_1884376_9 Membrane fusogenic activity K09806 - - 0.0000000000000000006948 92.0
TLS2_k127_1888836_0 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 612.0
TLS2_k127_1888836_1 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000003601 251.0
TLS2_k127_1888836_2 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000003952 166.0
TLS2_k127_1889101_0 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 0.0000002257 62.0
TLS2_k127_1889101_1 response regulator K02485 - - 0.00006446 47.0
TLS2_k127_1903315_0 alpha amylase catalytic K05343 - 3.2.1.1,5.4.99.16 0.0 1237.0
TLS2_k127_1903315_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.179e-297 925.0
TLS2_k127_1903315_2 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 4.777e-284 887.0
TLS2_k127_1903315_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 318.0
TLS2_k127_1904262_0 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 520.0
TLS2_k127_1904262_1 Adenylate cyclase - - - 0.0000000000000000000000000000000003799 133.0
TLS2_k127_1904667_0 Glycosyl-hydrolase 97 C-terminal, oligomerisation - - - 4.392e-222 707.0
TLS2_k127_1904667_1 gntR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 297.0
TLS2_k127_1904667_2 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.00000000000000001357 90.0
TLS2_k127_1917113_0 AbgT putative transporter family - - - 1.791e-203 647.0
TLS2_k127_1917113_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 377.0
TLS2_k127_1920692_0 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 374.0
TLS2_k127_1920692_1 PFAM transcriptional regulator domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000721 252.0
TLS2_k127_1920692_2 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000000000000000000001504 118.0
TLS2_k127_1920692_3 Cupin domain - - - 0.0000000000000000000000000003727 118.0
TLS2_k127_1925503_0 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006295 454.0
TLS2_k127_1925503_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 319.0
TLS2_k127_1934818_0 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 401.0
TLS2_k127_1934818_1 thiolester hydrolase activity K06889,K07000 - - 0.000000000000000000000000000000000000000001962 164.0
TLS2_k127_1941456_0 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K15578 - - 2.237e-259 809.0
TLS2_k127_1941456_1 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050,K15577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 344.0
TLS2_k127_1941456_2 Pyridine nucleotide-disulphide oxidoreductase K00362,K18359 - 1.2.1.58,1.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 313.0
TLS2_k127_1945213_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 465.0
TLS2_k127_1945213_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 289.0
TLS2_k127_1945213_2 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000002308 241.0
TLS2_k127_1945213_3 Domain of unknown function (DUF4124) - - - 0.00000000000000195 84.0
TLS2_k127_1947936_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.0 1131.0
TLS2_k127_1947936_1 alanine symporter K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 564.0
TLS2_k127_1947936_2 Glutathione S-transferase, N-terminal domain - - - 0.00000000491 64.0
TLS2_k127_1955533_0 Two component regulator three Y - - - 5.005e-212 700.0
TLS2_k127_1955533_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 356.0
TLS2_k127_1955533_2 Belongs to the glycosyl hydrolase 30 family K01201,K15924 - 3.2.1.136,3.2.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 347.0
TLS2_k127_1955533_3 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004583 247.0
TLS2_k127_1955533_4 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001664 222.0
TLS2_k127_1955533_5 collagen metabolic process K08677 - - 0.0000000000000000000000000000000000000002832 169.0
TLS2_k127_1955533_6 Lecithin retinol acyltransferase - - - 0.0000000000000000000000000000000000002029 147.0
TLS2_k127_1955533_7 cheY-homologous receiver domain - - - 0.0000000000000000000000000000003764 127.0
TLS2_k127_1969242_0 Amidohydrolase K07045 - - 1.546e-200 639.0
TLS2_k127_1969242_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007608 459.0
TLS2_k127_1969242_2 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 434.0
TLS2_k127_1969242_3 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 419.0
TLS2_k127_1969242_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 302.0
TLS2_k127_1969242_5 NADPH-quinone reductase (modulator of drug activity B) - - - 0.00000000000000000000000000000000000000000000000000000000000000003025 228.0
TLS2_k127_1969242_6 Putative phosphatase (DUF442) - - - 0.00000000000000000000000000000000000002928 149.0
TLS2_k127_1969242_7 transcriptional - - - 0.000000000000000000000000006411 113.0
TLS2_k127_1969242_8 Protein of unknown function (DUF2892) - - - 0.00000000000000000000006548 99.0
TLS2_k127_1969243_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 567.0
TLS2_k127_1969243_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009462 386.0
TLS2_k127_1969243_2 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 377.0
TLS2_k127_1988611_0 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 353.0
TLS2_k127_1988611_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003002 287.0
TLS2_k127_2005461_0 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000042 250.0
TLS2_k127_2005461_1 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000003747 176.0
TLS2_k127_2005461_2 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000009922 73.0
TLS2_k127_2008099_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1066.0
TLS2_k127_2008099_1 PFAM EAL domain K21025 - - 0.000000000000000000000007359 104.0
TLS2_k127_2018441_0 AMP-binding enzyme C-terminal domain - - - 4.304e-222 699.0
TLS2_k127_2018441_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 607.0
TLS2_k127_2018441_2 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.000000000000000000000000000002352 123.0
TLS2_k127_2018441_3 negative regulation of protein lipidation K19294 - - 0.000000000000000000000000000003874 123.0
TLS2_k127_2018441_4 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.00000000000000000000000001255 112.0
TLS2_k127_2018441_5 Protein of unknown function (DUF2591) - - - 0.000000000001237 73.0
TLS2_k127_2022110_0 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009886 338.0
TLS2_k127_2022110_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009576 286.0
TLS2_k127_2022110_2 flagellar K02404 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002579 259.0
TLS2_k127_2022110_3 response regulator receiver K03413 - - 0.000000000000000000000000000000000000000000000000000000000001633 211.0
TLS2_k127_2022110_4 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) K03414 - - 0.000000000000000000000000000000000000000000000294 176.0
TLS2_k127_2025648_0 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 1.608e-215 680.0
TLS2_k127_2025648_1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 376.0
TLS2_k127_2025648_2 Rnk N-terminus K06140 - - 0.00000000000000003007 83.0
TLS2_k127_2033131_0 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 392.0
TLS2_k127_2033131_1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000000000000000000000000000000000000000000006682 212.0
TLS2_k127_2042233_0 High confidence in function and specificity - - - 4.523e-208 669.0
TLS2_k127_2045998_0 Predicted membrane protein (DUF2339) - - - 3.841e-267 852.0
TLS2_k127_2045998_1 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 431.0
TLS2_k127_2045998_2 Protein of unknown function (DUF3999) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005679 322.0
TLS2_k127_2045998_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000004192 190.0
TLS2_k127_204737_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.671e-258 805.0
TLS2_k127_204737_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 608.0
TLS2_k127_204737_2 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 435.0
TLS2_k127_204737_3 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004337 305.0
TLS2_k127_204737_4 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.000000000000000000000005223 105.0
TLS2_k127_2049840_0 esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000001425 147.0
TLS2_k127_2049840_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000008415 117.0
TLS2_k127_2055365_0 GTP-binding protein TypA K06207 - - 5.281e-295 914.0
TLS2_k127_2055365_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 353.0
TLS2_k127_2055365_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000004243 186.0
TLS2_k127_2059664_0 NADH-ubiquinone oxidoreductase chain 4, amino terminus K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 541.0
TLS2_k127_2059664_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000004446 189.0
TLS2_k127_2061571_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 458.0
TLS2_k127_2061571_1 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.0000000000000000000000003768 109.0
TLS2_k127_2063531_0 glutamate synthase K00284 - 1.4.7.1 0.0 2588.0
TLS2_k127_2063531_1 TIGRFAM glutamate synthase, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 4.479e-263 816.0
TLS2_k127_2063531_2 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008298 301.0
TLS2_k127_2063531_3 - - - - 0.00000000003497 68.0
TLS2_k127_2064993_0 Dehydrogenase K13877 - 1.2.1.26 1.966e-205 651.0
TLS2_k127_2064993_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 408.0
TLS2_k127_2064993_10 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.00000002045 55.0
TLS2_k127_2064993_2 DEAD DEAH box helicase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 340.0
TLS2_k127_2064993_3 Pfam Glycosyl hydrolase family 65, N-terminal domain K15923 - 3.2.1.51 0.0000000000000000000000000000000000000000000000000000006075 195.0
TLS2_k127_2064993_4 PFAM RES domain - - - 0.000000000000000000000000000000000002749 143.0
TLS2_k127_2064993_5 Protein of unknown function (DUF559) - - - 0.00000000000000000000000000005581 119.0
TLS2_k127_2064993_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.0000000000005317 70.0
TLS2_k127_2064993_7 Protein of unknown function (DUF559) - - - 0.000000002961 66.0
TLS2_k127_2064993_8 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.000000004152 58.0
TLS2_k127_2064993_9 Protein of unknown function (DUF2384) - - - 0.000000005324 64.0
TLS2_k127_2068874_0 glycosyl hydrolase, BNR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000005041 193.0
TLS2_k127_2068874_1 - - - - 0.00000000001531 74.0
TLS2_k127_2068874_2 Pkd domain containing protein - - - 0.0001979 55.0
TLS2_k127_2069985_0 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 298.0
TLS2_k127_2069985_1 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004181 283.0
TLS2_k127_2069985_2 Fic/DOC family - - - 0.00000008084 56.0
TLS2_k127_2069985_3 - - - - 0.0001824 51.0
TLS2_k127_2074544_0 Transcriptional regulator K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 432.0
TLS2_k127_2074544_1 Domain of unknown function (DUF4383) - - - 0.00000000000000000000000000000000000000000000001727 175.0
TLS2_k127_2080520_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 9.829e-208 658.0
TLS2_k127_2080520_1 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000255 293.0
TLS2_k127_2080520_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002394 277.0
TLS2_k127_2080520_3 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005076 271.0
TLS2_k127_2080520_4 Glutathione S-transferase, C-terminal domain K07393 - 1.8.5.7 0.0000000000000000000000000000000000000000000000000000000002819 210.0
TLS2_k127_2086853_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 591.0
TLS2_k127_2086853_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000003031 56.0
TLS2_k127_2090955_0 Domain of unknown function DUF11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 580.0
TLS2_k127_209898_0 Belongs to the heme-copper respiratory oxidase family K02274,K15408 - 1.9.3.1 7.217e-318 994.0
TLS2_k127_209898_1 - - - - 0.0004576 51.0
TLS2_k127_2112053_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1613.0
TLS2_k127_2112053_1 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 541.0
TLS2_k127_2112053_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000001922 250.0
TLS2_k127_2112053_3 Dihydrodipicolinate reductase, C-terminus K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000001517 251.0
TLS2_k127_2112053_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000003464 217.0
TLS2_k127_2112053_5 RNA-binding protein K07574 - - 0.0000000000000000000009013 105.0
TLS2_k127_2112053_6 Domain of unknown function (DUF4149) - - - 0.000000000000001024 82.0
TLS2_k127_2132741_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 3.733e-242 796.0
TLS2_k127_2132741_1 Outer mitochondrial membrane transport complex protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 293.0
TLS2_k127_214695_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.486e-279 865.0
TLS2_k127_214695_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 2.25e-264 831.0
TLS2_k127_214695_10 Integral membrane protein (DUF2244) - - - 0.00000000005485 70.0
TLS2_k127_214695_2 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000876 451.0
TLS2_k127_214695_3 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 345.0
TLS2_k127_214695_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 343.0
TLS2_k127_214695_5 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000004721 269.0
TLS2_k127_214695_6 competence protein - - - 0.0000000000000000000000000000000000000000000000000000000000003964 220.0
TLS2_k127_214695_7 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000000000008221 181.0
TLS2_k127_214695_8 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000002954 168.0
TLS2_k127_214695_9 PFAM Cytochrome c oxidase assembly protein CtaG Cox11 K02258 - - 0.0000000000000000000000000000000000000000007639 162.0
TLS2_k127_2154498_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 373.0
TLS2_k127_2154498_1 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840 - 0.00000000000000000000000000000000000000000000000000000000000000000006681 236.0
TLS2_k127_216340_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1045.0
TLS2_k127_216340_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 458.0
TLS2_k127_216340_2 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 355.0
TLS2_k127_216340_3 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006878 315.0
TLS2_k127_216340_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000008187 237.0
TLS2_k127_216340_5 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000000000000000000000000007669 231.0
TLS2_k127_216340_6 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000118 224.0
TLS2_k127_216340_7 Translation initiation factor K03113 - - 0.0000000000000000000000000000001492 129.0
TLS2_k127_216340_8 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000007962 79.0
TLS2_k127_216340_9 - - - - 0.00003883 53.0
TLS2_k127_2184763_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 358.0
TLS2_k127_2184763_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008543 304.0
TLS2_k127_2187648_0 two component transcriptional regulator K02483,K13584 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 437.0
TLS2_k127_2187648_1 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 299.0
TLS2_k127_2187648_2 flagellar export protein FliJ - - - 0.0000000000000000000000000005512 117.0
TLS2_k127_2187648_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000273 85.0
TLS2_k127_2217119_0 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000002052 196.0
TLS2_k127_2217119_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000002866 118.0
TLS2_k127_2228423_0 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 576.0
TLS2_k127_2228423_1 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 394.0
TLS2_k127_2228423_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002752 265.0
TLS2_k127_2228423_3 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000003051 178.0
TLS2_k127_2228423_4 Autotransporter beta-domain - - - 0.000000000000000000000000000000000000000002167 179.0
TLS2_k127_2228423_5 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000002603 127.0
TLS2_k127_2241621_0 COG0471 Di- and tricarboxylate transporters - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006082 499.0
TLS2_k127_2241621_1 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000001534 184.0
TLS2_k127_2241621_2 - - - - 0.000000000000000000000000000000000000000000004011 173.0
TLS2_k127_2244641_0 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 494.0
TLS2_k127_2244641_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 404.0
TLS2_k127_2244641_2 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 326.0
TLS2_k127_2244641_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005123 346.0
TLS2_k127_2252015_0 Protein of unknown function (DUF1552) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004224 537.0
TLS2_k127_2252015_1 Ankyrin repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005672 504.0
TLS2_k127_2258753_0 RsbT co-antagonist protein rsbRD N-terminal domain K17763 - - 0.000000000000000000000000000000000000000000000000000000000000000000001242 242.0
TLS2_k127_2265103_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1244.0
TLS2_k127_2265103_1 Predicted membrane protein (DUF2207) - - - 4.106e-199 639.0
TLS2_k127_2265103_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 430.0
TLS2_k127_2265103_3 Sulfotransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 338.0
TLS2_k127_2265103_4 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000006019 220.0
TLS2_k127_2270303_0 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 487.0
TLS2_k127_2270303_1 Beta-ketoacyl synthase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000001258 194.0
TLS2_k127_2270303_2 pteridine-dependent deoxygenase K18240 - 4.1.3.40,4.1.3.45 0.00000000000000000000000000000000000000000000000005541 187.0
TLS2_k127_2270303_3 acyl carrier protein K02078 - - 0.00000000000000000000000000000000005334 135.0
TLS2_k127_2272002_0 Cytochrome c - - - 1.199e-298 933.0
TLS2_k127_2272002_1 Homoserine dehydrogenase, NAD binding domain - - - 1.519e-215 679.0
TLS2_k127_2272002_2 Patatin-like phospholipase - - - 4.191e-202 659.0
TLS2_k127_2274060_0 COG4240 Predicted kinase K15918 - 2.7.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 333.0
TLS2_k127_2274060_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007047 256.0
TLS2_k127_2274060_2 Filamentation induced by cAMP protein fic - - - 0.000000000000000000000000000000000000000000000000000000000000000000006805 238.0
TLS2_k127_2274060_3 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000002331 130.0
TLS2_k127_2274060_4 PspC domain - - - 0.000000000000005314 79.0
TLS2_k127_227967_0 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 4.165e-206 661.0
TLS2_k127_227967_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 299.0
TLS2_k127_227967_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007918 287.0
TLS2_k127_227967_3 LysM domain - - - 0.000000001736 66.0
TLS2_k127_2282189_0 Acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007573 600.0
TLS2_k127_2282189_1 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001606 249.0
TLS2_k127_2282189_2 Protein of unknown function (DUF962) - - - 0.00000000000000000000000000000000000000000000000002972 190.0
TLS2_k127_2293773_0 Glycosyl transferases group 1 - - - 0.0 1122.0
TLS2_k127_2293773_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 521.0
TLS2_k127_2293773_2 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 427.0
TLS2_k127_2293773_3 beta-1,4-mannooligosaccharide phosphorylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 292.0
TLS2_k127_2293773_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 291.0
TLS2_k127_2293773_5 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008149 291.0
TLS2_k127_2293773_6 - K07004 - - 0.00000004398 67.0
TLS2_k127_2301174_0 Cystathionine beta-synthase K01697 - 4.2.1.22 2.525e-194 616.0
TLS2_k127_2301174_1 cystathionine K01758 - 4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005999 558.0
TLS2_k127_2301174_2 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000000000002802 261.0
TLS2_k127_2301174_4 Domain of unknown function (DUF4350) - - - 0.0001375 50.0
TLS2_k127_230280_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 574.0
TLS2_k127_230280_1 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 523.0
TLS2_k127_230280_10 Belongs to the UPF0434 family K09791 - - 0.000000000000000000002547 94.0
TLS2_k127_230280_2 Lipoprotein releasing system transmembrane protein K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 471.0
TLS2_k127_230280_3 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 337.0
TLS2_k127_230280_4 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 289.0
TLS2_k127_230280_5 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 292.0
TLS2_k127_230280_6 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000006426 256.0
TLS2_k127_230280_7 PFAM MotA TolQ ExbB proton channel K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000002264 239.0
TLS2_k127_230280_8 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000000000000000000000004675 143.0
TLS2_k127_230280_9 Biopolymer transport protein K03559 - - 0.000000000000000000000000000000003 133.0
TLS2_k127_2305122_0 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 520.0
TLS2_k127_2305122_1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 443.0
TLS2_k127_2305122_2 Catalyzes a key regulatory step in fatty acid biosynthesis K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 357.0
TLS2_k127_2305122_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 293.0
TLS2_k127_2305122_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000704 231.0
TLS2_k127_2305122_5 PFAM methyltransferase - - - 0.0000000000000000000000000000000000000000000001687 177.0
TLS2_k127_2308856_0 PFAM NAD-glutamate dehydrogenase K15371 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 524.0
TLS2_k127_2308856_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 342.0
TLS2_k127_2308856_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001312 251.0
TLS2_k127_2316560_0 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 5.973e-195 616.0
TLS2_k127_2316560_1 Belongs to the Dps family - - - 0.000000000000000000000000000000000000000000000000000000000005212 218.0
TLS2_k127_2317131_0 Catalyzes the NAD( )-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non- methylotrophic organisms K00122 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 544.0
TLS2_k127_2317131_1 Domain of unknown function (DUF4440) - - - 0.0000001343 59.0
TLS2_k127_2324226_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007008 519.0
TLS2_k127_2324226_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000006087 227.0
TLS2_k127_2324226_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000004239 117.0
TLS2_k127_2326938_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 2.235e-242 755.0
TLS2_k127_2326938_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.434e-226 711.0
TLS2_k127_2326938_2 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009977 569.0
TLS2_k127_2326938_3 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001354 287.0
TLS2_k127_2326938_4 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000008338 185.0
TLS2_k127_2326938_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000002541 97.0
TLS2_k127_2337657_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 477.0
TLS2_k127_2337657_1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000001428 218.0
TLS2_k127_2341865_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 8.837e-206 651.0
TLS2_k127_2341865_1 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 347.0
TLS2_k127_2341865_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 322.0
TLS2_k127_2341865_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 310.0
TLS2_k127_2341865_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001808 265.0
TLS2_k127_2341865_5 VirC1 protein K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000005003 226.0
TLS2_k127_2341865_6 Protein of unknown function (DUF971) - - - 0.000000000000000000000000000000000000000000006415 165.0
TLS2_k127_2341865_7 Protein of unknown function, DUF484 K09921 - - 0.000000000000000000000000000000000001768 147.0
TLS2_k127_2359478_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000655 283.0
TLS2_k127_2359478_1 - - - - 0.00000000000000000000000000000000000000038 161.0
TLS2_k127_2359478_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000001249 119.0
TLS2_k127_2387636_0 Trehalase K01194 - 3.2.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 614.0
TLS2_k127_2387636_1 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 447.0
TLS2_k127_2387636_2 Zn-dependent protease with chaperone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008281 268.0
TLS2_k127_2387636_3 FecR protein K07165 - - 0.000000000000000000000000000000000000007922 158.0
TLS2_k127_2387636_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000007736 92.0
TLS2_k127_2420169_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 567.0
TLS2_k127_2423760_0 2-methylcitrate dehydratase K01720 - 4.2.1.79 1.286e-214 675.0
TLS2_k127_2423760_1 Belongs to the citrate synthase family K01659 - 2.3.3.5 7.631e-200 629.0
TLS2_k127_2423760_2 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 331.0
TLS2_k127_2423760_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K10715 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000002636 255.0
TLS2_k127_2445075_0 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 497.0
TLS2_k127_2445075_1 Binding-protein-dependent transport system inner membrane component K02050,K15552,K15554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 406.0
TLS2_k127_2445075_2 SCO1/SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000000000002224 217.0
TLS2_k127_2445075_3 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000002004 177.0
TLS2_k127_2445075_4 Abc transporter K02049 - - 0.00000000000000000000000000000000000000000000002499 172.0
TLS2_k127_2460380_0 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 1.027e-259 825.0
TLS2_k127_2460380_1 Involved in the TonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 459.0
TLS2_k127_2460380_2 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 323.0
TLS2_k127_2460380_3 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 316.0
TLS2_k127_2460380_4 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 311.0
TLS2_k127_2460380_5 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000000000000000000000000000000005489 204.0
TLS2_k127_2460380_6 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000002139 151.0
TLS2_k127_2460380_7 Putative peptidoglycan binding domain K02450 - - 0.000000000000000000000000000004143 135.0
TLS2_k127_2460380_8 (FHA) domain - - - 0.0000000000005673 81.0
TLS2_k127_2460380_9 TonB C terminal K03646 - - 0.000000003924 65.0
TLS2_k127_2466554_0 PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K00256,K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007645 471.0
TLS2_k127_2466554_1 - - - - 0.0000000000000000000344 93.0
TLS2_k127_2468999_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 380.0
TLS2_k127_2482221_0 dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 551.0
TLS2_k127_2482221_1 Protein of unknown function (DUF1282) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 410.0
TLS2_k127_2482221_2 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008608 383.0
TLS2_k127_2482221_3 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 343.0
TLS2_k127_2482221_4 serine protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 315.0
TLS2_k127_2482221_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000006447 188.0
TLS2_k127_2482221_6 CHRD domain - - - 0.00000000000000000000000000000000001907 142.0
TLS2_k127_2482221_7 - - - - 0.0000000000000000000000001965 118.0
TLS2_k127_2482221_8 Bacterial protein of unknown function (Gcw_chp) - - - 0.0000000000000000007097 96.0
TLS2_k127_2482221_9 Putative zinc-finger - - - 0.0000000000000006677 87.0
TLS2_k127_2497982_0 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 474.0
TLS2_k127_2497982_1 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 335.0
TLS2_k127_2497982_2 COG2706 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 321.0
TLS2_k127_2497982_3 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004043 279.0
TLS2_k127_2497982_4 DinB family - - - 0.00000000000000000000000000000000000000000000000000000000000206 216.0
TLS2_k127_2497982_5 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000000000001921 216.0
TLS2_k127_2497982_6 methyltransferase activity - - - 0.00000000000000000000000000000003469 131.0
TLS2_k127_2497982_7 Putative cyclase - - - 0.0000000000000000003187 87.0
TLS2_k127_2503999_0 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 334.0
TLS2_k127_2503999_1 C-terminal beta-propeller domain distantly related to WD-40 repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 308.0
TLS2_k127_2503999_2 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001013 284.0
TLS2_k127_2503999_3 - - - - 0.00000000000000000000000000000000000000000000000001001 188.0
TLS2_k127_2503999_4 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.0000000000000000000000000000000000000000849 161.0
TLS2_k127_2503999_5 sequence-specific DNA binding - - - 0.000000000000000000000000000000000000003459 151.0
TLS2_k127_2503999_6 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000009018 140.0
TLS2_k127_2503999_7 - - - - 0.00000000000000000000000000006295 121.0
TLS2_k127_2503999_8 Domain of unknown function (DU1801) - - - 0.00000000000000000000000001296 113.0
TLS2_k127_2503999_9 integral membrane protein - - - 0.0000000000000000000002785 105.0
TLS2_k127_251603_0 Por secretion system C-terminal sorting domain-containing protein - - - 0.00000000000000000000000000000000000000203 170.0
TLS2_k127_251603_1 extracellular matrix structural constituent - - - 0.0000000000000005987 93.0
TLS2_k127_2520512_0 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 488.0
TLS2_k127_2520512_1 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K01685 - 4.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 396.0
TLS2_k127_2520512_2 Aldo/keto reductase family K00064 - 1.1.1.122 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 359.0
TLS2_k127_2520512_3 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 308.0
TLS2_k127_2520512_4 PFAM regulatory protein IclR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000105 258.0
TLS2_k127_2520512_5 - - - - 0.00000000000000000000000000000000000008247 149.0
TLS2_k127_2520512_6 SAF - - - 0.00000000000000000008823 103.0
TLS2_k127_2530799_0 WD40-like Beta Propeller Repeat - - - 2.294e-262 826.0
TLS2_k127_2530799_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 560.0
TLS2_k127_2530799_10 Hydrolase K20862 - 3.1.3.102,3.1.3.104 0.00000000000000001459 86.0
TLS2_k127_2530799_11 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000147 96.0
TLS2_k127_2530799_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 428.0
TLS2_k127_2530799_3 FIST N domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 349.0
TLS2_k127_2530799_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 324.0
TLS2_k127_2530799_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001009 267.0
TLS2_k127_2530799_6 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000001753 213.0
TLS2_k127_2530799_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000002515 167.0
TLS2_k127_2530799_8 Dual specificity phosphatase, catalytic domain - - - 0.0000000000000000000000000000000000116 153.0
TLS2_k127_2530799_9 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000004707 117.0
TLS2_k127_2548014_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 434.0
TLS2_k127_2548014_1 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000001076 165.0
TLS2_k127_2548014_2 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000401 121.0
TLS2_k127_2548014_3 Protein involved in cellulose biosynthesis - - - 0.0000000000000000000018 106.0
TLS2_k127_2558569_0 pfkB family carbohydrate kinase K00874 - 2.7.1.45 4.653e-225 705.0
TLS2_k127_2558569_1 Aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 395.0
TLS2_k127_2558569_2 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000195 131.0
TLS2_k127_2558569_3 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.0000000000000000000000000001894 115.0
TLS2_k127_2573579_0 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 486.0
TLS2_k127_2573579_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 391.0
TLS2_k127_2573579_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000000000005054 189.0
TLS2_k127_2573672_0 double-stranded DNA 3'-5' exodeoxyribonuclease activity K01142 GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 448.0
TLS2_k127_2573672_1 ZIP Zinc transporter K07238 GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015086,GO:0015087,GO:0015093,GO:0015318,GO:0015684,GO:0015691,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0034755,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071421,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903874 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008684 323.0
TLS2_k127_2573672_2 proteins LmbE homologs - - - 0.00000000000000000000000000000014 135.0
TLS2_k127_2573672_3 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000002443 98.0
TLS2_k127_2573672_4 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000002866 60.0
TLS2_k127_2573672_5 Glycosyl transferases group 1 - - - 0.00000000211 66.0
TLS2_k127_2578145_0 Transcriptional regulatory protein, C terminal K02483,K13584 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 444.0
TLS2_k127_2578145_1 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007533 290.0
TLS2_k127_2578145_2 TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001964 257.0
TLS2_k127_2578145_3 Cytochrome c - - - 0.0000000000000000001822 91.0
TLS2_k127_2580622_0 Belongs to the glycosyl hydrolase 2 family K05970 - 3.1.1.53 3.175e-229 728.0
TLS2_k127_2580622_1 COG0457 FOG TPR repeat - - - 9.661e-199 635.0
TLS2_k127_2580622_2 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 464.0
TLS2_k127_2580622_3 Methyltransferase K00564 - 2.1.1.172 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 451.0
TLS2_k127_2580622_4 TraB family - - - 0.00000000000000000000000000000000000000000000000003471 193.0
TLS2_k127_2580622_5 overlaps another CDS with the same product name - - - 0.000000000000000000000000000007233 119.0
TLS2_k127_2580622_6 Tetratricopeptide repeat - - - 0.00000008364 62.0
TLS2_k127_2581022_0 cytochrome p450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 323.0
TLS2_k127_2581022_1 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000004479 113.0
TLS2_k127_2582710_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 2.145e-194 612.0
TLS2_k127_2582710_1 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 611.0
TLS2_k127_2582710_10 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000000002419 212.0
TLS2_k127_2582710_11 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000001568 181.0
TLS2_k127_2582710_12 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.000000000000000000000000000000000000000004596 164.0
TLS2_k127_2582710_13 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000489 155.0
TLS2_k127_2582710_14 Belongs to the UPF0149 family K09895 - - 0.000000000000000000000000001205 126.0
TLS2_k127_2582710_15 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000002226 109.0
TLS2_k127_2582710_2 peptidase M24B, X-Pro dipeptidase aminopeptidase K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000527 604.0
TLS2_k127_2582710_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 479.0
TLS2_k127_2582710_4 7 transmembrane helices usually fused to an inactive transglutaminase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 463.0
TLS2_k127_2582710_5 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006705 392.0
TLS2_k127_2582710_6 TIGRFAM alpha-L-glutamate ligase-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 380.0
TLS2_k127_2582710_7 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 376.0
TLS2_k127_2582710_8 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 325.0
TLS2_k127_2582710_9 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 292.0
TLS2_k127_2584708_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03696 - - 6.277e-207 680.0
TLS2_k127_2584708_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000003459 251.0
TLS2_k127_2627746_0 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 575.0
TLS2_k127_2627746_1 dehydratase - - - 0.000000000002051 69.0
TLS2_k127_2657944_0 Protein of unknown function, DUF255 K06888 - - 1.69e-252 797.0
TLS2_k127_2657944_1 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 488.0
TLS2_k127_2657944_10 3-hydroxyanthranilic acid dioxygenase K00452 - 1.13.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000007193 244.0
TLS2_k127_2657944_11 Belongs to the ComB family K05979 - 3.1.3.71 0.000000000000000000000000000000000000000000000000000000000004164 216.0
TLS2_k127_2657944_12 arylformamidase activity - - - 0.0000000000000000000000000000000000000000000000000000000004229 220.0
TLS2_k127_2657944_13 ApaG domain K06195 - - 0.00000000000000000000000000000000000000000000000000001945 190.0
TLS2_k127_2657944_14 Putative member of DMT superfamily (DUF486) K09922 - - 0.0000000000000000000000000000000000000000000000000003322 189.0
TLS2_k127_2657944_15 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000000000000000000000000009711 172.0
TLS2_k127_2657944_16 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000104 170.0
TLS2_k127_2657944_17 bis(5'-adenosyl)-triphosphatase activity - - - 0.00000000000000000000000000000000000000004116 157.0
TLS2_k127_2657944_18 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.0000000000000000000000000000000000000003549 151.0
TLS2_k127_2657944_19 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000002156 141.0
TLS2_k127_2657944_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 439.0
TLS2_k127_2657944_20 PFAM TfoX N-terminal domain K07343 - - 0.00000000000009402 77.0
TLS2_k127_2657944_21 - - - - 0.00000000007618 68.0
TLS2_k127_2657944_3 SAM-dependent K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 445.0
TLS2_k127_2657944_4 FAD binding domain K00486 - 1.14.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006406 441.0
TLS2_k127_2657944_5 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004476 339.0
TLS2_k127_2657944_6 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 340.0
TLS2_k127_2657944_7 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 338.0
TLS2_k127_2657944_8 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001829 278.0
TLS2_k127_2657944_9 phenazine biosynthesis phzc phzf - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003567 277.0
TLS2_k127_2664193_0 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 615.0
TLS2_k127_2664193_1 Alternative locus ID K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 414.0
TLS2_k127_2664193_2 Transketolase, thiamine diphosphate binding domain K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 321.0
TLS2_k127_2664193_3 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000002698 162.0
TLS2_k127_2679628_0 chemotaxis protein K03407 - 2.7.13.3 1.866e-212 683.0
TLS2_k127_2679628_1 chemotaxis protein K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 393.0
TLS2_k127_2679628_2 COG0784 FOG CheY-like receiver K03413 - - 0.000000000000000000000000000000000000000007324 158.0
TLS2_k127_2679628_3 chemotaxis signal transduction protein K03408 - - 0.000000000000000000000000002125 115.0
TLS2_k127_2679628_4 factor (Antagonist - - - 0.000007689 53.0
TLS2_k127_2684513_0 Beta-L-arabinofuranosidase, GH127 K09955 - - 3.503e-242 764.0
TLS2_k127_2684513_1 gntR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004999 283.0
TLS2_k127_2684513_2 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000003162 145.0
TLS2_k127_2684513_3 membrane K07148 - - 0.000000000000004033 79.0
TLS2_k127_2686890_0 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 293.0
TLS2_k127_2686890_1 Redoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 284.0
TLS2_k127_2686890_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K04756 - - 0.0000000000000000000000000000000000000000000000000000003344 200.0
TLS2_k127_2686890_3 CHAT domain - - - 0.00000000000000000000000000000000000000000000000003436 195.0
TLS2_k127_2686890_4 Belongs to the Nudix hydrolase family K01518 - 3.6.1.17 0.0000000000000000000000000000000000000000002181 161.0
TLS2_k127_2686890_5 Copper chaperone PCu(A)C K09796 - - 0.00000000000000000000001007 106.0
TLS2_k127_2687139_0 Belongs to the Orn Lys Arg decarboxylase class-II family K00928,K12526 - 2.7.2.4,4.1.1.20 6.686e-288 904.0
TLS2_k127_2687139_1 ORF6N domain - - - 0.000000000000000000000000000000000000000000000000002031 192.0
TLS2_k127_268775_0 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 631.0
TLS2_k127_268775_1 Circadian clock protein KaiC K08482 - - 0.000008339 52.0
TLS2_k127_2689633_0 Flagellar hook protein FlgE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 499.0
TLS2_k127_2689633_1 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 490.0
TLS2_k127_2689633_2 basal body rod K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 385.0
TLS2_k127_2689633_3 TIGRFAM flagellar basal-body rod protein FlgF K02391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 286.0
TLS2_k127_2689633_4 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000000000000000000000000000000000000000000000001135 211.0
TLS2_k127_2689633_5 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.00000000000000000000000000000000000000000003484 168.0
TLS2_k127_2702310_0 MASE1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006828 281.0
TLS2_k127_2719878_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1084.0
TLS2_k127_2719878_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 1.097e-203 643.0
TLS2_k127_2719878_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 407.0
TLS2_k127_2719878_3 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 388.0
TLS2_k127_2719878_4 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000003695 225.0
TLS2_k127_2719878_5 Could be involved in insertion of integral membrane proteins into the membrane K08998 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - 0.0000000000000000000000000000722 117.0
TLS2_k127_2719878_6 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.000000000000000000000002863 105.0
TLS2_k127_2719878_7 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000001741 94.0
TLS2_k127_2719878_8 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000008126 69.0
TLS2_k127_2732374_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000004074 239.0
TLS2_k127_2732374_1 Fis family transcriptional regulator K03413 - - 0.000000000000000000000000000000000000000000002055 171.0
TLS2_k127_2732374_2 MAPEG family - - - 0.000000000000000000000000000000232 131.0
TLS2_k127_2732374_3 - - - - 0.00000000000000009618 87.0
TLS2_k127_2742420_0 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 350.0
TLS2_k127_2742420_1 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000005667 151.0
TLS2_k127_2742420_2 dTDP-4-dehydrorhamnose 3,5-epimerase activity K19068 - 1.1.1.367 0.000000000000000000000000000000008063 132.0
TLS2_k127_2742420_3 Protein of unknown function, DUF255 - - - 0.000000000000000000000002894 109.0
TLS2_k127_2768330_0 Belongs to the glycosyl hydrolase 43 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 589.0
TLS2_k127_2768330_1 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 438.0
TLS2_k127_2768330_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 356.0
TLS2_k127_2768330_3 MFS/sugar transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006537 269.0
TLS2_k127_2768330_4 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007325 246.0
TLS2_k127_2768330_5 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000001313 151.0
TLS2_k127_2768330_6 Protein conserved in bacteria - - - 0.00000000000000000000001262 117.0
TLS2_k127_2768330_7 O-methyltransferase activity - - - 0.00000000000001401 76.0
TLS2_k127_2770317_0 Amidinotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 310.0
TLS2_k127_2770317_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon K03524 GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003009 281.0
TLS2_k127_2770317_2 Asparaginase, N-terminal K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000000000000000000149 209.0
TLS2_k127_2770317_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000004561 185.0
TLS2_k127_2770317_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000004406 162.0
TLS2_k127_2770317_5 - - - - 0.00000000000000000001393 102.0
TLS2_k127_2770317_6 PFAM phosphoesterase, PA-phosphatase related - - - 0.000000000001156 71.0
TLS2_k127_277685_0 Belongs to the MurCDEF family K01924 GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 569.0
TLS2_k127_277685_1 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 406.0
TLS2_k127_277685_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 380.0
TLS2_k127_277685_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006462 275.0
TLS2_k127_2789273_0 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 612.0
TLS2_k127_2789273_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 450.0
TLS2_k127_2789273_2 - - - - 0.00000000000324 71.0
TLS2_k127_2792238_0 DNA polymerase type-B family K02336 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 607.0
TLS2_k127_2792238_1 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 467.0
TLS2_k127_2792238_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000008401 203.0
TLS2_k127_2792238_3 Protein of unknown function (DUF1203) - - - 0.0000000000000000000000000000000000000000000000000001157 191.0
TLS2_k127_2792238_4 - - - - 0.000000000000000000006748 101.0
TLS2_k127_2814069_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1315.0
TLS2_k127_2814069_1 PFAM Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase K13924 - 2.1.1.80,3.1.1.61 8.584e-273 872.0
TLS2_k127_2814069_10 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000002536 177.0
TLS2_k127_2814069_11 PAS domain - - - 0.0000000000000000000000000000000002371 145.0
TLS2_k127_2814069_12 Protein of unknown function (DUF1059) - - - 0.000000002929 60.0
TLS2_k127_2814069_2 tRNA-splicing ligase RtcB - - - 5.072e-205 645.0
TLS2_k127_2814069_3 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 366.0
TLS2_k127_2814069_4 PFAM Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 344.0
TLS2_k127_2814069_5 DNA ligase OB-like domain K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 301.0
TLS2_k127_2814069_6 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 293.0
TLS2_k127_2814069_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 292.0
TLS2_k127_2814069_8 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000005866 211.0
TLS2_k127_2814069_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.00000000000000000000000000000000000000000000000000000001731 201.0
TLS2_k127_2816144_0 PFAM UDP-N-acetylglucosamine 2-epimerase K01791,K08068 - 3.2.1.183,5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 500.0
TLS2_k127_2816144_1 PFAM SAF domain K01654 - 2.5.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 387.0
TLS2_k127_2816144_2 Methyltransferase small domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008586 350.0
TLS2_k127_2816144_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000002269 248.0
TLS2_k127_2816144_4 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000005271 152.0
TLS2_k127_2816144_5 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000004368 124.0
TLS2_k127_2816144_6 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000004881 116.0
TLS2_k127_2816144_7 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 0.00000000000000168 85.0
TLS2_k127_282587_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008378,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000002128 199.0
TLS2_k127_282587_1 PFAM Glutathione S-transferase K11209 - - 0.000000000000006655 76.0
TLS2_k127_2829741_0 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000002274 204.0
TLS2_k127_2829741_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000002524 194.0
TLS2_k127_2829741_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000003374 187.0
TLS2_k127_2829741_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000006195 169.0
TLS2_k127_2829741_4 Short chain dehydrogenase - - - 0.0000000000000000003999 89.0
TLS2_k127_2829741_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000002251 68.0
TLS2_k127_2864943_0 Response regulator of the LytR AlgR family K08083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008763 247.0
TLS2_k127_2864943_1 signal transduction protein with a C-terminal ATPase domain K08082 - 2.7.13.3 0.000000000000000000000000000000000000001883 152.0
TLS2_k127_2864943_2 Bacterial protein of unknown function (DUF883) - - - 0.000000000000000000008485 97.0
TLS2_k127_2864943_3 membrane - - - 0.0000001146 59.0
TLS2_k127_2871964_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1306.0
TLS2_k127_2871964_1 Zn-dependent protease with chaperone function K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 454.0
TLS2_k127_2873983_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 1.868e-312 966.0
TLS2_k127_2873983_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 6.077e-295 914.0
TLS2_k127_2873983_10 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000000001193 234.0
TLS2_k127_2873983_11 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000006762 203.0
TLS2_k127_2873983_12 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000008478 184.0
TLS2_k127_2873983_13 MucB/RseB C-terminal domain K03598 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152 - 0.000000000000000000000000000000000000000000000001256 187.0
TLS2_k127_2873983_14 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000000000000000000000000000001351 124.0
TLS2_k127_2873983_15 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.00000000000000000000000000006222 121.0
TLS2_k127_2873983_16 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.00000000000000000000000000007518 125.0
TLS2_k127_2873983_17 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000689 112.0
TLS2_k127_2873983_18 Peptidoglycan-binding protein, CsiV - - - 0.00000000000000001714 92.0
TLS2_k127_2873983_19 Flavinator of succinate dehydrogenase K09159 - - 0.000000000001793 72.0
TLS2_k127_2873983_2 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 460.0
TLS2_k127_2873983_20 Protein of unknown function (DUF1674) - - - 0.00000000003605 67.0
TLS2_k127_2873983_21 PFAM glutaredoxin 2 - - - 0.000000001124 63.0
TLS2_k127_2873983_22 Domain of unknown function (DUF4845) - - - 0.000000005184 63.0
TLS2_k127_2873983_23 Negative regulator of sigma E activity K03597 - - 0.00001198 55.0
TLS2_k127_2873983_3 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 442.0
TLS2_k127_2873983_4 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 395.0
TLS2_k127_2873983_5 3'-5' exonuclease K07501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 350.0
TLS2_k127_2873983_6 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 342.0
TLS2_k127_2873983_7 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 312.0
TLS2_k127_2873983_8 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005468 281.0
TLS2_k127_2873983_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003745 259.0
TLS2_k127_2888342_0 ATP-dependent helicase K03579 - 3.6.4.13 1.133e-284 897.0
TLS2_k127_2888342_1 thiamine-containing compound biosynthetic process K02051 - - 1.139e-247 775.0
TLS2_k127_2888342_2 ATPase family associated with various cellular activities (AAA) - - - 3.783e-223 705.0
TLS2_k127_2888342_3 PspA/IM30 family K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 337.0
TLS2_k127_2888342_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 348.0
TLS2_k127_2888342_5 Acyl-CoA thioesterase K10805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007954 254.0
TLS2_k127_2888342_6 Belongs to the pseudouridine synthase RsuA family K06178,K06181 - 5.4.99.20,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000003358 227.0
TLS2_k127_2888342_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000156 226.0
TLS2_k127_2888342_8 response regulator K02479,K07684 - - 0.000000000000000000000000000000000000000913 158.0
TLS2_k127_2912163_0 Hpt domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004067 419.0
TLS2_k127_2912163_1 Chemotaxis phosphatase CheX K03409 - - 0.00000000000000000000000000000000000000001714 157.0
TLS2_k127_2912163_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000003692 150.0
TLS2_k127_2912163_3 - - - - 0.00000000000002893 80.0
TLS2_k127_2912163_4 Endonuclease/Exonuclease/phosphatase family - - - 0.00003243 50.0
TLS2_k127_2912163_5 cheY-homologous receiver domain - - - 0.00003698 56.0
TLS2_k127_2912547_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006218 471.0
TLS2_k127_2912547_1 helix_turn_helix gluconate operon transcriptional repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 359.0
TLS2_k127_2912547_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001347 267.0
TLS2_k127_2912547_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000009666 179.0
TLS2_k127_2912547_4 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000002785 147.0
TLS2_k127_2912547_5 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000000007829 118.0
TLS2_k127_2921897_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 370.0
TLS2_k127_2921897_1 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000004882 254.0
TLS2_k127_2921897_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000002834 237.0
TLS2_k127_2921897_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0033554,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051716,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000001518 232.0
TLS2_k127_2921897_4 Histidine biosynthesis bifunctional protein HisB K01089 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000000002895 207.0
TLS2_k127_2933201_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 2.856e-249 775.0
TLS2_k127_2933201_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 396.0
TLS2_k127_2933201_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005147 361.0
TLS2_k127_2933201_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000002879 238.0
TLS2_k127_2933201_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000000000000000000000000000002133 186.0
TLS2_k127_2939545_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1335.0
TLS2_k127_2939545_1 RDD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 385.0
TLS2_k127_2939545_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 348.0
TLS2_k127_2939545_3 HDOD domain K03088 - - 0.0000000000000000000000000000000000000000000000000000173 194.0
TLS2_k127_2939545_4 RDD family - - - 0.000000001578 58.0
TLS2_k127_2939545_5 Domain of unknown function (DU1801) - - - 0.000000001931 60.0
TLS2_k127_2951238_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1098.0
TLS2_k127_2951238_1 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 450.0
TLS2_k127_2951238_2 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002217 282.0
TLS2_k127_2951238_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005281 267.0
TLS2_k127_2971031_0 ABC transporter - - - 1.573e-245 767.0
TLS2_k127_2971031_1 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005573 547.0
TLS2_k127_2971031_2 COG1943 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006365 342.0
TLS2_k127_2971031_3 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005577 295.0
TLS2_k127_2999501_0 Protein of unknown function (DUF4038) - - - 5.04e-322 994.0
TLS2_k127_2999501_1 Histidine kinase - - - 2.853e-237 768.0
TLS2_k127_2999501_10 MlrC C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 443.0
TLS2_k127_2999501_11 NAD(P)H-dependent FMN reductase K11811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 376.0
TLS2_k127_2999501_12 Transglycosylase SLT domain K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 290.0
TLS2_k127_2999501_13 COG0659 Sulfate permease and related transporters (MFS superfamily) K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001664 287.0
TLS2_k127_2999501_14 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001393 263.0
TLS2_k127_2999501_15 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000009572 238.0
TLS2_k127_2999501_16 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000004579 218.0
TLS2_k127_2999501_17 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000004981 175.0
TLS2_k127_2999501_18 DnaJ molecular chaperone homology domain - - - 0.0000000000000000000000000000000000000000003525 175.0
TLS2_k127_2999501_19 Regulatory protein ArsR K03892 - - 0.000000000000000000000000001394 117.0
TLS2_k127_2999501_2 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 2.118e-221 698.0
TLS2_k127_2999501_20 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000002543 101.0
TLS2_k127_2999501_3 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 3.191e-209 662.0
TLS2_k127_2999501_4 Fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 2.062e-203 635.0
TLS2_k127_2999501_5 PFAM major facilitator superfamily MFS_1 - - - 1.101e-195 623.0
TLS2_k127_2999501_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 584.0
TLS2_k127_2999501_7 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009813 528.0
TLS2_k127_2999501_8 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 507.0
TLS2_k127_2999501_9 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 458.0
TLS2_k127_3003390_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1194.0
TLS2_k127_3003390_1 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 495.0
TLS2_k127_3003390_2 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 311.0
TLS2_k127_3003390_3 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008225 256.0
TLS2_k127_3003390_4 - - - - 0.00000000000000000000000000000000000000000000000000000001191 204.0
TLS2_k127_3003390_5 GGDEF domain - - - 0.000000000000000000000000000001079 135.0
TLS2_k127_3003390_6 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000005078 74.0
TLS2_k127_3003929_0 Polysaccharide pyruvyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 439.0
TLS2_k127_3003929_1 Membrane protein involved in the export of O-antigen and teichoic acid K03328 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 445.0
TLS2_k127_3003929_2 Glycosyl transferases group 1 - - - 0.00000000000000003315 85.0
TLS2_k127_3010486_0 Receptor K02014 - - 1.411e-300 951.0
TLS2_k127_3010486_1 Receptor K02014 - - 3.12e-264 842.0
TLS2_k127_3010486_2 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008474 386.0
TLS2_k127_3010486_3 Domain of unknown function (DUF4880) K07165 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001104 263.0
TLS2_k127_3010486_4 bleomycin resistance protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000615 243.0
TLS2_k127_3010486_5 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001607 242.0
TLS2_k127_3010486_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000001691 242.0
TLS2_k127_3010486_7 Transferase K02527 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000001402 162.0
TLS2_k127_3010486_8 peptidase - - - 0.00000000000000000000000002884 119.0
TLS2_k127_3010486_9 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.000000212 57.0
TLS2_k127_3016975_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 5.684e-271 851.0
TLS2_k127_3016975_1 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 508.0
TLS2_k127_3016975_2 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019222,GO:0019439,GO:0034353,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000002843 214.0
TLS2_k127_3016975_3 Iron--sulfur cluster insertion protein erpA K15724 - - 0.0000000000000000000000000000000000000000000000000003336 187.0
TLS2_k127_3016975_4 PFAM Uncharacterised protein family (UPF0093) K08973 - - 0.000000000000000000000000000000000000000000000888 169.0
TLS2_k127_3016975_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000001912 136.0
TLS2_k127_3016975_6 - - - - 0.0000000000000000000000000006354 124.0
TLS2_k127_3016975_7 peptidase - - - 0.0000001525 54.0
TLS2_k127_3033507_0 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006203 324.0
TLS2_k127_3033507_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000011 278.0
TLS2_k127_3033507_2 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000008929 214.0
TLS2_k127_3033507_3 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000007143 213.0
TLS2_k127_3033507_4 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000000004194 159.0
TLS2_k127_3033507_5 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000007049 106.0
TLS2_k127_3033507_6 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000009011 85.0
TLS2_k127_3033507_7 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000004069 74.0
TLS2_k127_3053978_0 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 316.0
TLS2_k127_3053978_1 Oxidoreductase K16044 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0070402,GO:0097159,GO:0102497,GO:1901265,GO:1901363 1.1.1.371 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 298.0
TLS2_k127_3053978_2 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000000000108 206.0
TLS2_k127_3053978_3 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000189 172.0
TLS2_k127_3057223_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 319.0
TLS2_k127_3057223_1 peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000003471 266.0
TLS2_k127_3057223_2 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000002135 189.0
TLS2_k127_3060620_0 Site-specific recombinase, DNA invertase Pin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 527.0
TLS2_k127_3060620_1 Phage integrase family - - - 0.0000000000000000006789 88.0
TLS2_k127_307591_0 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 542.0
TLS2_k127_307591_1 Domain of unknown function (DUF4154) - - - 0.0000000000000000003279 94.0
TLS2_k127_3077582_0 glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 519.0
TLS2_k127_3077582_1 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000957 391.0
TLS2_k127_3077582_2 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 378.0
TLS2_k127_3077582_3 Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position K11211 - 2.7.1.166 0.00000000000000000000000000000000000000000000000001815 189.0
TLS2_k127_3077582_4 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) K02517,K12974 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 0.00000000000000001867 84.0
TLS2_k127_3077582_5 PFAM glycosyl transferase family 9 - - - 0.0000000001664 63.0
TLS2_k127_310357_0 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 339.0
TLS2_k127_310357_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 326.0
TLS2_k127_310357_2 Diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 314.0
TLS2_k127_310357_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000001079 262.0
TLS2_k127_310357_4 Copper amine oxidase - - - 0.0000000000000000000000000000000000000000000000565 182.0
TLS2_k127_310357_5 Domain of unknown function (DUF892) - - - 0.00000000000000001896 92.0
TLS2_k127_310357_6 LTXXQ motif family protein K06006 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0010033,GO:0014070,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051082,GO:0061077,GO:1990507 - 0.0002115 50.0
TLS2_k127_3109137_0 COG3039 Transposase and inactivated derivatives, IS5 family K07481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 372.0
TLS2_k127_3110307_0 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000826 466.0
TLS2_k127_3110307_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 384.0
TLS2_k127_3110307_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 371.0
TLS2_k127_3110307_3 PFAM Sulphur oxidation protein SoxZ K17226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001433 268.0
TLS2_k127_3110307_4 COG0607 Rhodanese-related sulfurtransferase - - - 0.0000000000000000000000000000000000000005845 156.0
TLS2_k127_3110307_5 Bacterial SH3 domain homologues - - - 0.000001444 58.0
TLS2_k127_3114039_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 588.0
TLS2_k127_3114039_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 316.0
TLS2_k127_3114039_2 Histidine kinase K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000003903 280.0
TLS2_k127_3114039_3 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000002032 182.0
TLS2_k127_3122447_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000002664 182.0
TLS2_k127_3124136_0 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 427.0
TLS2_k127_3124136_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000003714 196.0
TLS2_k127_3124136_2 Haloacid dehalogenase-like hydrolase - - - 0.00002855 51.0
TLS2_k127_3128204_0 response to abiotic stimulus K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 393.0
TLS2_k127_3128204_1 Domain of unknown function (DUF4372) - - - 0.000005504 54.0
TLS2_k127_3128283_0 Outer membrane receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 514.0
TLS2_k127_3128283_1 E COG0620 Methionine synthase II (cobalamin-independent) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 491.0
TLS2_k127_3128283_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003507 267.0
TLS2_k127_3128283_3 PFAM NADPH-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000000000000000001965 214.0
TLS2_k127_3128283_4 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000001554 157.0
TLS2_k127_3128283_5 - - - - 0.0000000002756 63.0
TLS2_k127_3135571_0 Sodium/hydrogen exchanger family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006336 281.0
TLS2_k127_3135571_1 mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000003104 230.0
TLS2_k127_3135571_2 Thioredoxin reductase K00384 - 1.8.1.9 0.0001651 44.0
TLS2_k127_3137823_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 2.329e-290 901.0
TLS2_k127_3137823_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 0.0000009853 51.0
TLS2_k127_3140253_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 354.0
TLS2_k127_3163718_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 553.0
TLS2_k127_3163718_1 PFAM Transglutaminase-like K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 508.0
TLS2_k127_3163718_2 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000088 385.0
TLS2_k127_3163718_3 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000007877 241.0
TLS2_k127_3164869_0 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006219 261.0
TLS2_k127_3164869_1 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000006866 214.0
TLS2_k127_3203460_0 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 470.0
TLS2_k127_3203460_1 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000003685 252.0
TLS2_k127_3203460_2 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000002347 184.0
TLS2_k127_3207440_0 Amidohydrolase family K06015 - 3.5.1.81 3.481e-222 706.0
TLS2_k127_3207440_1 symporter activity K03307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 595.0
TLS2_k127_3207440_2 PFAM UBA THIF-type NAD FAD binding protein K21029,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 374.0
TLS2_k127_3207440_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 338.0
TLS2_k127_3207440_4 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000003545 230.0
TLS2_k127_3207440_5 Protein kinase domain - - - 0.000000000000000000000000000000000000000000000000483 193.0
TLS2_k127_3207440_6 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000002363 154.0
TLS2_k127_3214241_0 Homospermidine synthase K00808 - 2.5.1.44 5.252e-239 747.0
TLS2_k127_3214241_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 2.211e-217 692.0
TLS2_k127_3214241_10 Protein of unknown function (DUF1232) - - - 0.00000000000000000000002932 107.0
TLS2_k127_3214241_2 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 402.0
TLS2_k127_3214241_3 SMART Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 323.0
TLS2_k127_3214241_4 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 290.0
TLS2_k127_3214241_5 Belongs to the Nudix hydrolase family K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000001269 218.0
TLS2_k127_3214241_6 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000007751 190.0
TLS2_k127_3214241_7 - - - - 0.0000000000000000000000000000000000000000000000001539 183.0
TLS2_k127_3214241_8 - - - - 0.000000000000000000000000000000008155 142.0
TLS2_k127_3214241_9 PFAM RNP-1 like RNA-binding protein - - - 0.0000000000000000000000000000142 121.0
TLS2_k127_3225030_0 PFAM peptidase M3A and M3B, thimet oligopeptidase F K01414 - 3.4.24.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 506.0
TLS2_k127_3225030_1 PFAM Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 342.0
TLS2_k127_3240785_0 Amidohydrolase family - - - 2.034e-237 739.0
TLS2_k127_3240785_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 476.0
TLS2_k127_3240785_2 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 295.0
TLS2_k127_3240785_3 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000008443 184.0
TLS2_k127_3240785_4 - - - - 0.0000000000000000000000000002686 117.0
TLS2_k127_3254495_0 Glycosyl hydrolase family 10 K01181 - 3.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006336 478.0
TLS2_k127_3254495_1 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 325.0
TLS2_k127_3254495_2 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 305.0
TLS2_k127_3254495_3 COG0725 ABC-type molybdate transport system, periplasmic component K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005387 286.0
TLS2_k127_3254495_4 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000000005705 116.0
TLS2_k127_3262352_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 554.0
TLS2_k127_3262352_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 505.0
TLS2_k127_3262352_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000005298 192.0
TLS2_k127_3262352_3 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.00000000000000001796 84.0
TLS2_k127_3275300_0 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 407.0
TLS2_k127_3275300_1 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000001795 178.0
TLS2_k127_3280702_0 FMN-dependent alpha-hydroxy acid dehydrogenase K00101 - 1.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 511.0
TLS2_k127_3280702_1 Protein of unknown function (DUF2868) - - - 0.000000000000000000000000000000000000000000000002443 192.0
TLS2_k127_3280702_2 Domain of unknown function (DUF3482) - - - 0.00000000000000000000000000001888 120.0
TLS2_k127_3296159_0 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 520.0
TLS2_k127_3296159_1 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 365.0
TLS2_k127_3296159_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 322.0
TLS2_k127_3298556_0 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 450.0
TLS2_k127_3298556_1 N-terminal domain of (some) glycogen debranching enzymes - - - 0.000000000000000000000000000000000000000000000000000001949 198.0
TLS2_k127_3314404_0 PFAM Amylo-alpha-16-glucosidase - - - 3.272e-253 800.0
TLS2_k127_3314404_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 486.0
TLS2_k127_3314404_2 Type 12 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 306.0
TLS2_k127_3314404_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000002914 216.0
TLS2_k127_331773_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 4.87e-200 629.0
TLS2_k127_331773_1 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 464.0
TLS2_k127_331773_2 Belongs to the peptidase M17 family K01255,K01259 - 3.4.11.1,3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 377.0
TLS2_k127_331773_3 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009081 342.0
TLS2_k127_331773_4 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis K03683 GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004623 271.0
TLS2_k127_331773_5 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000008964 230.0
TLS2_k127_331773_6 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000002643 154.0
TLS2_k127_331773_7 Diguanylate cyclase - - - 0.00000000000000000000000004045 108.0
TLS2_k127_331773_8 Protein of unknown function (DUF1289) K06938 - - 0.00000008084 56.0
TLS2_k127_3323439_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1141.0
TLS2_k127_3323439_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 3.397e-210 660.0
TLS2_k127_3323439_2 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 0.0000000000000000000000000000000000000004665 158.0
TLS2_k127_3323439_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000001637 133.0
TLS2_k127_3323439_4 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000001711 128.0
TLS2_k127_3359222_0 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 539.0
TLS2_k127_3359222_1 Putative diguanylate phosphodiesterase K21023 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 346.0
TLS2_k127_3359222_2 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 318.0
TLS2_k127_3359222_3 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000003379 195.0
TLS2_k127_3359222_4 PFAM glycosyl transferase group 1 - - - 0.0000005258 52.0
TLS2_k127_3370790_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004319 264.0
TLS2_k127_3370790_1 Glyoxalase-like domain K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000005197 229.0
TLS2_k127_3370790_2 Si dkey-205h13.2 - - - 0.00000000000000001046 89.0
TLS2_k127_3370790_3 Peptidase S9 prolyl oligopeptidase active site - - - 0.000000000001598 69.0
TLS2_k127_3373326_0 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000002133 176.0
TLS2_k127_3378226_0 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 4.44e-229 716.0
TLS2_k127_3378226_1 bifunctional purine biosynthesis protein PurH K00602 GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 1.643e-209 664.0
TLS2_k127_3378226_10 Endonuclease/Exonuclease/phosphatase family - - - 0.0000076 51.0
TLS2_k127_3378226_2 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000897 542.0
TLS2_k127_3378226_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 421.0
TLS2_k127_3378226_4 Ribosomal protein L11 methyltransferase K02687 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 304.0
TLS2_k127_3378226_5 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000003236 194.0
TLS2_k127_3378226_6 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.00000000000000000000000000000000000000000000000009673 182.0
TLS2_k127_3378226_7 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000004584 131.0
TLS2_k127_3378226_8 Protein of unknown function (DUF3426) - - - 0.000000000000000000000601 109.0
TLS2_k127_3378226_9 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters K03557 - - 0.00000000000000000000896 94.0
TLS2_k127_3391597_0 Belongs to the peptidase S1B family - - - 1.722e-216 692.0
TLS2_k127_3391597_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 536.0
TLS2_k127_3391597_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 400.0
TLS2_k127_3391597_3 YceI-like domain - - - 0.0000000000000000000000000000002482 128.0
TLS2_k127_3391597_4 Multidrug efflux pump K03327 GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0022857,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 - 0.000000000000000000000000005399 118.0
TLS2_k127_3391597_5 - - - - 0.0000000000000000005696 97.0
TLS2_k127_3406499_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 1.875e-290 896.0
TLS2_k127_3406499_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003638 234.0
TLS2_k127_3406499_2 - - - - 0.00000000000000000000000000000000000000000000000000000399 195.0
TLS2_k127_3408371_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 4.306e-207 657.0
TLS2_k127_3408371_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 573.0
TLS2_k127_3408371_2 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000002302 210.0
TLS2_k127_3408371_3 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000003485 123.0
TLS2_k127_3408371_4 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 0.000000000000000002767 97.0
TLS2_k127_342999_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 363.0
TLS2_k127_342999_1 histone H2A K63-linked ubiquitination K02283 - - 0.0000000002746 70.0
TLS2_k127_3440841_0 TIGRFAM FeS assembly protein SufB K09014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 510.0
TLS2_k127_3440841_1 Belongs to the class I fructose-bisphosphate aldolase family K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 431.0
TLS2_k127_3440841_2 PFAM ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 349.0
TLS2_k127_3440841_3 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007141 263.0
TLS2_k127_3440841_4 ABC-type transport system involved in resistance to organic solvents auxiliary component K07323 - - 0.0000000000000000000000000000000000000000055 164.0
TLS2_k127_3440841_5 MlaD protein K02067 - - 0.00000000000000000000000000000000000001858 149.0
TLS2_k127_3440841_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000001678 145.0
TLS2_k127_3440841_7 STAS domain K07122 - - 0.00000000000008506 77.0
TLS2_k127_3456738_0 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 522.0
TLS2_k127_3456738_1 COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 427.0
TLS2_k127_3456738_10 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000000000001139 222.0
TLS2_k127_3456738_11 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 - - 0.0000000000000000000000000000000000000000000000000000000008784 213.0
TLS2_k127_3456738_12 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000004042 199.0
TLS2_k127_3456738_13 Belongs to the UPF0307 family K09889 - - 0.0000000000000000000000000000008809 128.0
TLS2_k127_3456738_14 Type II secretory pathway component ExeA K02450,K12283 - - 0.000000000000000000000007394 106.0
TLS2_k127_3456738_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 419.0
TLS2_k127_3456738_3 ABC transporter substrate-binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007577 368.0
TLS2_k127_3456738_4 ribonuclease BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 356.0
TLS2_k127_3456738_5 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 346.0
TLS2_k127_3456738_6 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 297.0
TLS2_k127_3456738_7 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000048 276.0
TLS2_k127_3456738_8 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000009855 243.0
TLS2_k127_3456738_9 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000000000002809 221.0
TLS2_k127_3468560_0 Protein phosphatase 2A homologues, catalytic domain. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 315.0
TLS2_k127_3468560_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 290.0
TLS2_k127_3468560_2 Belongs to the UPF0337 (CsbD) family - - - 0.0000000000000000009377 89.0
TLS2_k127_3468560_3 Acetyltransferase K03789,K14742 - 2.3.1.128 0.000000007491 67.0
TLS2_k127_3472676_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 6.085e-253 791.0
TLS2_k127_3472676_1 Rhomboid family - - - 0.000000000000000000003953 94.0
TLS2_k127_3487996_0 Belongs to the enoyl-CoA hydratase isomerase family K00022,K07514 - 1.1.1.35,4.2.1.17,5.3.3.8 5.238e-302 941.0
TLS2_k127_3487996_1 peptidase S9 - - - 1.615e-269 846.0
TLS2_k127_3487996_2 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 7.526e-197 622.0
TLS2_k127_3487996_3 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 347.0
TLS2_k127_3487996_4 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001441 228.0
TLS2_k127_3487996_5 Alpha/beta hydrolase family - - - 0.00000000000000000000000000002227 130.0
TLS2_k127_3487996_6 Adenylate cyclase - - - 0.0003789 53.0
TLS2_k127_3499421_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 544.0
TLS2_k127_3499421_1 COG1538 Outer membrane protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 314.0
TLS2_k127_3499421_2 PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000001854 187.0
TLS2_k127_3499421_3 Sulfurtransferase - - - 0.0000000000000000000000009662 106.0
TLS2_k127_3500330_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 396.0
TLS2_k127_3500330_1 cell redox homeostasis - - - 0.00000000000000000000000000000000000000000000000002466 187.0
TLS2_k127_3502154_0 Acetolactate synthase K01652 - 2.2.1.6 3.117e-282 880.0
TLS2_k127_3502154_1 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000506 358.0
TLS2_k127_3502154_2 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000001349 235.0
TLS2_k127_3502154_3 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000000003951 183.0
TLS2_k127_3502154_4 acetolactate synthase, small K01653 - 2.2.1.6 0.0000000000000000000000000000000000000001924 158.0
TLS2_k127_3502154_5 Reprolysin (M12B) family zinc metalloprotease - - - 0.0000000000000000000000000000000000000002262 171.0
TLS2_k127_3502957_0 SMART Chromosomal replication initiator DnaA domain - - - 0.000000000000000000000000000274 121.0
TLS2_k127_3502957_1 RHS Repeat - - - 0.00000000000000000001258 99.0
TLS2_k127_3540791_0 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 616.0
TLS2_k127_3540791_1 Bacterial transcription activator, effector binding domain K13652,K13653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 385.0
TLS2_k127_3540791_2 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000004955 188.0
TLS2_k127_3540791_3 negative regulation of transcription, DNA-templated - - - 0.0000000000000000000000000000000000000000000002173 171.0
TLS2_k127_3540791_4 Domain of unknown function (DUF4974) K07165 - - 0.00000000000000000000000000008731 129.0
TLS2_k127_3540791_5 Peptidase M56, BlaR1 - - - 0.00000000000485 68.0
TLS2_k127_3540791_6 GGDEF domain - - - 0.00007138 47.0
TLS2_k127_354672_0 Major facilitator superfamily K08218 - - 9.566e-207 651.0
TLS2_k127_354672_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000001654 61.0
TLS2_k127_355173_0 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001159 265.0
TLS2_k127_355173_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000007837 235.0
TLS2_k127_3561226_0 Glycosyltransferase Family 4 K13668 - 2.4.1.346 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009329 411.0
TLS2_k127_3561226_1 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 306.0
TLS2_k127_3561226_2 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 298.0
TLS2_k127_3561226_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003995 242.0
TLS2_k127_3561226_4 Protein kinase domain - - - 0.0000000000000000000000000000000000000000000000001545 199.0
TLS2_k127_3561226_5 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000005111 93.0
TLS2_k127_3566811_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008776,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016741,GO:0016742,GO:0016772,GO:0016774,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 576.0
TLS2_k127_3566811_1 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 301.0
TLS2_k127_3566811_2 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000009717 223.0
TLS2_k127_3566811_3 Protein of unknown function (DUF2959) - - - 0.00000000000000000000000000000000000000000000000000000000000006533 222.0
TLS2_k127_3566811_4 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000426 100.0
TLS2_k127_3592551_1 Type ii and iii secretion system protein - - - 0.000000000000000000000000000001077 131.0
TLS2_k127_3592551_2 - - - - 0.000000000000000000000000000007774 123.0
TLS2_k127_3609419_0 response regulator receiver K02487,K06596 - - 2.913e-217 724.0
TLS2_k127_3609419_1 von willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 578.0
TLS2_k127_3609419_2 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000003809 252.0
TLS2_k127_3609419_3 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000002444 235.0
TLS2_k127_3609419_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000000000000000000000000000000008994 244.0
TLS2_k127_3609419_5 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000000000000000000000000000000000000001414 228.0
TLS2_k127_3609419_6 methylated DNA-protein cysteine methyltransferase K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 - 0.0000000000000000000000001995 111.0
TLS2_k127_3609419_7 CheW-like domain K06598 - - 0.0000000000000000000006507 101.0
TLS2_k127_3626739_0 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009553 297.0
TLS2_k127_3626739_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008507 274.0
TLS2_k127_3626739_2 Yip1 domain - - - 0.000000000000000000005222 101.0
TLS2_k127_3626739_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000002814 84.0
TLS2_k127_3636523_0 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 7.043e-216 680.0
TLS2_k127_3636523_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 482.0
TLS2_k127_3636523_2 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000005627 133.0
TLS2_k127_3642518_0 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 621.0
TLS2_k127_3642518_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000000000000000008018 205.0
TLS2_k127_3642518_2 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000008423 196.0
TLS2_k127_3642518_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000004642 93.0
TLS2_k127_3649067_0 TonB dependent receptor K16091 - - 3.597e-320 992.0
TLS2_k127_3649067_1 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001347 295.0
TLS2_k127_3649067_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001162 233.0
TLS2_k127_3649067_3 PRC-barrel domain - - - 0.0000000000000000000000000000000000000000004388 162.0
TLS2_k127_3668369_0 Putative esterase K07214 - - 7.493e-198 623.0
TLS2_k127_3668369_1 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 471.0
TLS2_k127_3668369_2 Belongs to the glycosyl hydrolase 13 family K07214 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 436.0
TLS2_k127_3668369_3 PFAM Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 405.0
TLS2_k127_3668369_4 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000187 282.0
TLS2_k127_3668369_5 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001497 282.0
TLS2_k127_3668369_6 carbohydrate transport - - - 0.000000000000000000000000000000000000000000000000000000000000001175 223.0
TLS2_k127_3668369_7 Trehalose utilisation - - - 0.00000000006788 66.0
TLS2_k127_3668369_8 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.0000002369 57.0
TLS2_k127_3697971_0 aldehyde-lyase activity K01621 - 4.1.2.22,4.1.2.9 0.0 1261.0
TLS2_k127_3697971_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 2.055e-197 634.0
TLS2_k127_3697971_2 COG0474 Cation transport ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 571.0
TLS2_k127_3697971_3 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000005074 148.0
TLS2_k127_3704301_0 Belongs to the SUA5 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 287.0
TLS2_k127_3704301_1 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000002764 200.0
TLS2_k127_3704301_2 Belongs to the BolA IbaG family K05527 - - 0.0000000000000000000005731 104.0
TLS2_k127_370994_0 PQQ enzyme repeat K00117 - 1.1.5.2 8.458e-288 899.0
TLS2_k127_370994_1 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000002315 209.0
TLS2_k127_370994_2 Outer membrane protein W K07275 - - 0.000000000002716 66.0
TLS2_k127_3710142_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 5.271e-268 848.0
TLS2_k127_3710142_1 1,4-alpha-glucan branching enzyme activity K00700,K01187,K01236,K17734 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,3.2.1.141,3.2.1.20 1.024e-258 813.0
TLS2_k127_3710142_2 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 9.374e-242 769.0
TLS2_k127_3710142_3 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 3.105e-196 634.0
TLS2_k127_3710142_4 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000002265 147.0
TLS2_k127_3710142_5 Domain of unknown function (DUF4440) - - - 0.0000003777 59.0
TLS2_k127_3714262_0 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 534.0
TLS2_k127_3714262_1 PAS fold - - - 0.000000000000000000000000000000000001367 156.0
TLS2_k127_3714262_2 FMN-dependent alpha-hydroxy acid dehydrogenase K00101 - 1.1.2.3 0.0000000000000000000000000003887 116.0
TLS2_k127_3714262_3 Mo-molybdopterin cofactor metabolic process K03636 - - 0.0000000000000000002014 91.0
TLS2_k127_3739662_0 Outer membrane protein beta-barrel family - - - 2.699e-237 753.0
TLS2_k127_3739662_1 outer membrane autotransporter barrel - - - 0.000000000000000005598 92.0
TLS2_k127_374594_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 556.0
TLS2_k127_374594_1 Anthranilate synthase component I K01657,K01665 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 485.0
TLS2_k127_374594_10 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000001617 122.0
TLS2_k127_374594_11 proteolysis - - - 0.0000000000000000000000005837 112.0
TLS2_k127_374594_12 General secretion pathway protein J K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.0000000000000000002817 92.0
TLS2_k127_374594_13 Type II secretion system (T2SS), protein I - - - 0.0000000000000000003703 96.0
TLS2_k127_374594_14 general secretion pathway protein h K02457 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000000005729 83.0
TLS2_k127_374594_2 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 360.0
TLS2_k127_374594_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 326.0
TLS2_k127_374594_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 331.0
TLS2_k127_374594_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000377 233.0
TLS2_k127_374594_6 PFAM Aminotransferase, class IV K02619 - 4.1.3.38 0.00000000000000000000000000000000000000000000000000000000004384 216.0
TLS2_k127_374594_7 General secretion pathway protein K02456 - - 0.00000000000000000000000000000000000000000000000004799 183.0
TLS2_k127_374594_8 Pilus assembly protein PilZ K02676 - - 0.00000000000000000000000000000000000000000000000005239 181.0
TLS2_k127_374594_9 DNA polymerase III, delta subunit, C terminal K02341 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0000000000000000000000000000000000000000000007762 179.0
TLS2_k127_3771348_0 ATPase domain of DNA mismatch repair MUTS family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 589.0
TLS2_k127_3771610_0 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 516.0
TLS2_k127_3771610_1 C-terminal domain of 1-Cys peroxiredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 312.0
TLS2_k127_3773549_0 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 508.0
TLS2_k127_3773549_1 PBP superfamily domain K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 467.0
TLS2_k127_3773549_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 425.0
TLS2_k127_3773549_3 Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 423.0
TLS2_k127_3773549_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 389.0
TLS2_k127_3773549_5 peptidase S9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005803 319.0
TLS2_k127_3773549_6 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 289.0
TLS2_k127_3773549_7 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.000000000000000000000000000000000000000000000009056 180.0
TLS2_k127_3773549_8 Putative porin - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000004167 187.0
TLS2_k127_377705_0 peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 597.0
TLS2_k127_377705_1 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 327.0
TLS2_k127_3785794_0 Histidine kinase K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 370.0
TLS2_k127_3785794_1 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000001211 96.0
TLS2_k127_3785794_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000009972 85.0
TLS2_k127_3786969_0 integral membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 532.0
TLS2_k127_3786969_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 519.0
TLS2_k127_3786969_2 Serine/threonine phosphatases, family 2C, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 308.0
TLS2_k127_3786969_3 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) K17762 - - 0.0000000000000000000000000000000000000000000000000006909 186.0
TLS2_k127_3786969_4 Histidine kinase-like ATPases K17752 - 2.7.11.1 0.000000000000000000000000000000000000000000000000004805 184.0
TLS2_k127_3786969_5 Anti-sigma-factor antagonist K17763 - - 0.000000000000000000000000000000000000000000002425 166.0
TLS2_k127_3786969_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000003932 175.0
TLS2_k127_3786969_7 cheY-homologous receiver domain - - - 0.00000000000000003513 88.0
TLS2_k127_3790036_0 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 295.0
TLS2_k127_3790036_1 Lipocalin-like domain - - - 0.0000000000000000000000000002468 121.0
TLS2_k127_3790036_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000001261 115.0
TLS2_k127_3790036_3 Protein of unknown function (DUF433) - - - 0.0000000000000002821 80.0
TLS2_k127_3790036_4 Metallo-beta-lactamase superfamily - - - 0.000000000000007452 75.0
TLS2_k127_3799677_0 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 306.0
TLS2_k127_3799677_1 DoxX - - - 0.000000000000000000000000000000001388 135.0
TLS2_k127_3799677_2 - - - - 0.000000000000000008292 85.0
TLS2_k127_3799677_3 methyltransferase activity - - - 0.000000000000014 82.0
TLS2_k127_3799677_4 Chromatin associated protein KTI12 K07028 - - 0.000000000006706 66.0
TLS2_k127_3817625_0 Hypothetical glycosyl hydrolase 6 - - - 0.0 1088.0
TLS2_k127_3817625_1 E-Z type HEAT repeats - - - 1.005e-311 991.0
TLS2_k127_3817625_2 X-Pro dipeptidyl-peptidase (S15 family) - - - 1.615e-265 830.0
TLS2_k127_3817625_3 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000466 231.0
TLS2_k127_3817625_4 Belongs to the ompA family - - - 0.000000000000009049 83.0
TLS2_k127_382664_0 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 317.0
TLS2_k127_382664_1 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.00000000000000000000000000000000000000006897 155.0
TLS2_k127_382664_2 flagellar protein FliS K02422 - - 0.00000000000000000000000000002581 121.0
TLS2_k127_382664_3 FlaG protein K06603 - - 0.0000000000005491 74.0
TLS2_k127_3844077_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.791e-198 627.0
TLS2_k127_3844077_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 2.545e-198 631.0
TLS2_k127_3844077_10 Protein of unknown function, DUF484 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000576 287.0
TLS2_k127_3844077_11 Cytochrome C1 family K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008973 264.0
TLS2_k127_3844077_12 Stringent starvation protein A K03599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001901 250.0
TLS2_k127_3844077_13 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000007166 241.0
TLS2_k127_3844077_14 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000001611 213.0
TLS2_k127_3844077_15 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 0.0000000000000000000000000000000000000000000000001971 184.0
TLS2_k127_3844077_16 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 0.0000000000000000000000000000000000000000000003212 171.0
TLS2_k127_3844077_17 Sigma 54 modulation protein K05808 - - 0.0000000000000000000000000000000000001253 144.0
TLS2_k127_3844077_18 Stringent starvation protein B K03600 GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904 - 0.000000000000000000000000000000000008915 141.0
TLS2_k127_3844077_19 Belongs to the BolA IbaG family - - - 0.0000000000000000000002996 99.0
TLS2_k127_3844077_2 permease protein K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 536.0
TLS2_k127_3844077_20 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm K09774 - - 0.00001066 55.0
TLS2_k127_3844077_21 lipopolysaccharide transmembrane transporter activity K02040,K11719 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0017089,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 - 0.0001227 51.0
TLS2_k127_3844077_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 463.0
TLS2_k127_3844077_4 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 426.0
TLS2_k127_3844077_5 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 416.0
TLS2_k127_3844077_6 Arabinose 5-phosphate isomerase K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 400.0
TLS2_k127_3844077_7 ABC transporter K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 353.0
TLS2_k127_3844077_8 Belongs to the peptidase S1C family K04691,K04771,K04772 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 332.0
TLS2_k127_3844077_9 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 316.0
TLS2_k127_3844825_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 467.0
TLS2_k127_3844825_1 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 398.0
TLS2_k127_3844825_2 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000006646 120.0
TLS2_k127_384600_0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.00000000000000000000000000000000000000000000000000000000001639 215.0
TLS2_k127_384600_1 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000002446 194.0
TLS2_k127_384600_2 Nitroreductase family - - - 0.0000000000000000000000000000000000000000009157 167.0
TLS2_k127_384600_3 Cytochrome c-type biogenesis protein K02200 - - 0.0004827 44.0
TLS2_k127_3851813_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.696e-282 888.0
TLS2_k127_3851813_1 PFAM Type II secretion system protein E - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 512.0
TLS2_k127_3851813_10 Part of a membrane complex involved in electron transport K03617 - - 0.000000000000000000002743 101.0
TLS2_k127_3851813_2 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 449.0
TLS2_k127_3851813_3 Part of a membrane complex involved in electron transport K03615 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 430.0
TLS2_k127_3851813_4 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 380.0
TLS2_k127_3851813_5 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 351.0
TLS2_k127_3851813_6 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 316.0
TLS2_k127_3851813_7 Part of a membrane complex involved in electron transport K03612 - - 0.000000000000000000000000000000000000000000000000000000000003639 214.0
TLS2_k127_3851813_8 Part of a membrane complex involved in electron transport K03616 - - 0.0000000000000000000000000000000000000000000000000003192 190.0
TLS2_k127_3851813_9 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000001325 147.0
TLS2_k127_3865009_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 2.561e-251 806.0
TLS2_k127_3865009_1 protein conserved in bacteria - - - 0.00000000000000000000001001 101.0
TLS2_k127_389500_0 Thi4 family - - - 4.18e-257 801.0
TLS2_k127_389500_1 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 586.0
TLS2_k127_389500_10 Glycosyl hydrolase family 115 - - - 0.0000000003799 61.0
TLS2_k127_389500_2 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 496.0
TLS2_k127_389500_3 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 329.0
TLS2_k127_389500_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002974 296.0
TLS2_k127_389500_5 FG-GAP repeat - - - 0.00000000000000000000000000000000000000529 166.0
TLS2_k127_389500_6 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00000000000000000000000000000000001086 152.0
TLS2_k127_389500_7 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.00000000000000000000000000004063 119.0
TLS2_k127_389500_8 Glycosyl hydrolase family 115 - - - 0.000000000000000000000000004458 113.0
TLS2_k127_389500_9 COG3209 Rhs family protein - - - 0.0000000000000000000001263 112.0
TLS2_k127_3910955_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 3.694e-280 875.0
TLS2_k127_3910955_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 3.779e-242 769.0
TLS2_k127_3910955_10 Putative zinc-finger - - - 0.00000000007294 74.0
TLS2_k127_3910955_11 PFAM conserved - - - 0.00000002447 64.0
TLS2_k127_3910955_2 serine protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 326.0
TLS2_k127_3910955_3 PFAM YicC-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002861 273.0
TLS2_k127_3910955_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000001149 231.0
TLS2_k127_3910955_5 Glutathione peroxidase K00432 GO:0003674,GO:0003824,GO:0004601,GO:0004602,GO:0005575,GO:0005623,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.11.1.9 0.000000000000000000000000000000000000000000000000000000001994 203.0
TLS2_k127_3910955_6 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000001373 186.0
TLS2_k127_3910955_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000001477 176.0
TLS2_k127_3910955_8 Protein of unknown function (DUF541) K09807 GO:0000302,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071575,GO:0071944,GO:0098552,GO:1901700,GO:1901701 - 0.0000000000000008313 87.0
TLS2_k127_3910955_9 Membrane protein implicated in regulation of membrane protease activity K07340 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000005588 74.0
TLS2_k127_392263_0 acyl-CoA dehydrogenase K06445 GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - 5.464e-288 908.0
TLS2_k127_392263_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 488.0
TLS2_k127_392263_2 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 374.0
TLS2_k127_392263_3 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.00000000000000000000000000000000000000000000000006817 182.0
TLS2_k127_3926652_0 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000004801 159.0
TLS2_k127_3926652_1 Glycosyl hydrolases family 16 - - - 0.0000000000000000000000000000000000000005797 161.0
TLS2_k127_3926652_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000007456 111.0
TLS2_k127_3934311_0 COG0303 Molybdopterin biosynthesis enzyme K03750,K07219 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001205 265.0
TLS2_k127_3936116_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K12276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 524.0
TLS2_k127_3936116_1 Type II secretion system (T2SS), protein F K02653,K12278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 379.0
TLS2_k127_3940820_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000002056 201.0
TLS2_k127_3940820_1 Domain of unknown function (DUF1857) - - - 0.000000000000000000000000000001511 127.0
TLS2_k127_3940820_2 - - - - 0.0000000000008578 71.0
TLS2_k127_3942338_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 317.0
TLS2_k127_3942338_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000738 258.0
TLS2_k127_3942338_2 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000003419 235.0
TLS2_k127_3942338_3 polysaccharide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000002311 231.0
TLS2_k127_3942338_4 TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated - - - 0.000000000000000000000000000000000000000000000000000000009749 206.0
TLS2_k127_3949289_0 UPF0313 protein - - - 0.0 1069.0
TLS2_k127_3949289_1 Uncharacterized protein conserved in bacteria (DUF2219) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000861 266.0
TLS2_k127_3949289_2 Methylpurine-DNA glycosylase (MPG) K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000002138 211.0
TLS2_k127_3949289_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000001615 164.0
TLS2_k127_3955394_0 4-hydroxybenzoate K00481,K05712 GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.14.13.127,1.14.13.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007926 529.0
TLS2_k127_3955394_1 metal-dependent hydrolase of the TIM-barrel fold K03392,K10220 - 4.1.1.45,4.2.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002395 522.0
TLS2_k127_3955394_2 protein conserved in bacteria K16514 GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 5.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 483.0
TLS2_k127_3955394_3 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 338.0
TLS2_k127_3955394_4 Aldolase/RraA K02553,K10218 - 4.1.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 308.0
TLS2_k127_3955394_5 Domain of unknown function (DUF1932) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004296 254.0
TLS2_k127_3956057_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0 1635.0
TLS2_k127_3956057_1 TIGRFAM ATP-binding cassette protein, ChvD family - - - 1.281e-259 807.0
TLS2_k127_3956057_2 Histidine ammonia-lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 449.0
TLS2_k127_3956057_3 Type VI secretion K07169,K11894,K11913 - - 0.000000000000000000000000000000000000000000000000000000001157 218.0
TLS2_k127_3956057_4 - - - - 0.0000000000000000000000000000000000000000000001131 176.0
TLS2_k127_3956057_5 Domain of unknown function (DUF1820) - - - 0.0000000000000000000000000000000000002162 144.0
TLS2_k127_3962521_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 529.0
TLS2_k127_3962521_1 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004255 426.0
TLS2_k127_3962521_2 Transcriptional regulator K07734 - - 0.00000000000000000000000000000000000000007018 154.0
TLS2_k127_3962521_3 Protein of unknown function (DUF3187) - - - 0.0001546 46.0
TLS2_k127_3962521_4 Pleckstrin homology domain-containing family O member - - - 0.0008562 43.0
TLS2_k127_3973788_0 SMART PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 546.0
TLS2_k127_3973788_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000007143 62.0
TLS2_k127_3973788_2 - - - - 0.0009954 50.0
TLS2_k127_3977679_0 Phosphoglucose isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008013 351.0
TLS2_k127_3977679_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000003862 261.0
TLS2_k127_3977679_2 Universal stress protein - - - 0.000000000000000000000000000000004263 140.0
TLS2_k127_3981183_0 Belongs to the arginase family K01476,K01480,K12255,K18459 - 3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 521.0
TLS2_k127_3981183_1 PFAM Ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005671 490.0
TLS2_k127_3981183_2 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000000000000000538 222.0
TLS2_k127_3981183_3 helix_turn_helix ASNC type - - - 0.000000000000000000000000001136 114.0
TLS2_k127_3983270_0 prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000004363 156.0
TLS2_k127_3983270_1 Type II transport protein GspH K08084 - - 0.00000002471 63.0
TLS2_k127_3983270_2 type IV pilus modification protein PilV K02671 - - 0.0000002176 59.0
TLS2_k127_3984695_0 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000003648 182.0
TLS2_k127_3984695_1 ECF sigma factor - - - 0.00000000000000000000000000000000000000000003352 168.0
TLS2_k127_3984695_2 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.00000000000000000000000000000000000002475 163.0
TLS2_k127_3984695_3 COG0724 RNA-binding proteins (RRM domain) - - - 0.00000000000000000000000000003695 119.0
TLS2_k127_3984695_4 Protein of unknown function (DUF2380) - - - 0.00000000000000000000000007949 116.0
TLS2_k127_3996406_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 1.915e-271 853.0
TLS2_k127_3996406_1 TonB-dependent Receptor Plug Domain - - - 1.131e-266 856.0
TLS2_k127_3996406_10 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004975 268.0
TLS2_k127_3996406_11 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000397 226.0
TLS2_k127_3996406_12 2OG-Fe(II) oxygenase superfamily K07394 - - 0.0000000000000000000000000000000000000000000000000000000002972 208.0
TLS2_k127_3996406_13 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000001451 194.0
TLS2_k127_3996406_14 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000001271 96.0
TLS2_k127_3996406_15 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000003406 78.0
TLS2_k127_3996406_16 type II secretion system protein K - - - 0.0004347 53.0
TLS2_k127_3996406_2 Tryptophan halogenase K14266 - 1.14.19.9 9.83e-213 672.0
TLS2_k127_3996406_3 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 1.154e-210 670.0
TLS2_k127_3996406_4 Tryptophan halogenase K14266 - 1.14.19.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 614.0
TLS2_k127_3996406_5 Glycosyl Hydrolase Family 88 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009864 572.0
TLS2_k127_3996406_6 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 510.0
TLS2_k127_3996406_7 intracellular protease amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 412.0
TLS2_k127_3996406_8 Protein of unknown function (DUF418) K07148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 364.0
TLS2_k127_3996406_9 Tryptophan halogenase K14266 - 1.14.19.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 333.0
TLS2_k127_401469_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 532.0
TLS2_k127_401469_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002849 257.0
TLS2_k127_401469_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000001908 145.0
TLS2_k127_401469_3 Domain of unknown function (DUF4184) - - - 0.0003371 47.0
TLS2_k127_4022637_0 TRANSCRIPTIONal - - - 0.000000000000000000000000000000000000000000000000000000000000000000002842 241.0
TLS2_k127_4022637_1 - - - - 0.00000000000000000000000000000000000001143 148.0
TLS2_k127_4022637_2 Protein of unknown function (DUF433) - - - 0.0000000000123 68.0
TLS2_k127_4037225_0 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.0 1030.0
TLS2_k127_4037225_1 Protein conserved in bacteria - - - 1.394e-209 667.0
TLS2_k127_4037225_2 Protein conserved in bacteria - - - 1.016e-205 649.0
TLS2_k127_4037225_4 TIGRFAM phage conjugal plasmid C-4 type zinc finger protein, TraR family - - - 0.00000000000000000000000000000000000000141 148.0
TLS2_k127_403856_0 receptor - - - 0.0 1125.0
TLS2_k127_403856_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001594 281.0
TLS2_k127_403856_2 Protein of unknown function (DUF4197) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006085 277.0
TLS2_k127_403856_3 MerR, DNA binding K13639 - - 0.00000000000000000000000000000000000000000000000000000000001022 210.0
TLS2_k127_403856_4 Hemerythrin HHE cation binding domain - - - 0.000002449 57.0
TLS2_k127_4043526_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009712 549.0
TLS2_k127_405006_0 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 639.0
TLS2_k127_405006_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006324 271.0
TLS2_k127_405028_0 COG1404 Subtilisin-like serine proteases K14645 GO:0005575,GO:0005576 - 4.024e-206 661.0
TLS2_k127_405028_1 Aminotransferase K14287 GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 326.0
TLS2_k127_4054399_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1067.0
TLS2_k127_4054399_1 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 488.0
TLS2_k127_4054399_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000636 272.0
TLS2_k127_4061387_0 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 598.0
TLS2_k127_4061387_1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000002265 264.0
TLS2_k127_4090474_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 590.0
TLS2_k127_4090474_1 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 353.0
TLS2_k127_4090474_2 protease with the C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 357.0
TLS2_k127_4090474_3 Hsp20/alpha crystallin family - - - 0.0000000000000000000000000000000000000000005517 162.0
TLS2_k127_4090474_4 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.0000000000000000000003924 98.0
TLS2_k127_4091717_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 417.0
TLS2_k127_4091717_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 310.0
TLS2_k127_4091717_2 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 293.0
TLS2_k127_4091717_3 membrane K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004351 299.0
TLS2_k127_4091717_4 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000624 250.0
TLS2_k127_4091717_5 Hydrolase of X-linked nucleoside diphosphate N terminal - - - 0.0000000000000000000000000000000000000000000000000000000000001051 219.0
TLS2_k127_4104796_0 transcriptional regulator K21405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000794 436.0
TLS2_k127_4104796_1 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000008285 235.0
TLS2_k127_4104796_2 Coenzyme PQQ synthesis protein D (PqqD) K06138 - - 0.0000112 53.0
TLS2_k127_4110438_0 PFAM Alcohol dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 384.0
TLS2_k127_4110438_1 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 350.0
TLS2_k127_4110438_2 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 324.0
TLS2_k127_4110438_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006338 304.0
TLS2_k127_4110438_4 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000000000000000000000537 190.0
TLS2_k127_4110438_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000000003148 175.0
TLS2_k127_4110438_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000005366 151.0
TLS2_k127_4110438_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000001063 120.0
TLS2_k127_4125440_0 With GlrK is part of a two-component signal transduction system regulating glmY K07715 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 494.0
TLS2_k127_4125440_1 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 469.0
TLS2_k127_4125440_2 Glucose / Sorbosone dehydrogenase K00117,K21430 - 1.1.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 421.0
TLS2_k127_4125440_3 lipolytic protein G-D-S-L family K00983 - 2.7.7.43 0.0000000000000000000000000000000000000000000000000104 188.0
TLS2_k127_4125440_4 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000001305 142.0
TLS2_k127_4125440_5 - - - - 0.00000000001711 73.0
TLS2_k127_4125440_6 membrane protein involved in D-alanine K19294 - - 0.000007034 51.0
TLS2_k127_4129175_0 AAA ATPase, central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 610.0
TLS2_k127_4129175_1 Belongs to the Orn Lys Arg decarboxylase class-II family K01581,K01586 - 4.1.1.17,4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000002503 267.0
TLS2_k127_4153986_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 295.0
TLS2_k127_4153986_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 289.0
TLS2_k127_4153986_2 Transcriptional regulator K07013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006984 245.0
TLS2_k127_4153986_3 Amidohydrolase family - - - 0.0000005554 51.0
TLS2_k127_4154241_0 Flagellar protein export ATPase FliI K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 588.0
TLS2_k127_4154241_1 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 440.0
TLS2_k127_4154241_2 The M ring may be actively involved in energy transduction K02409 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005934 425.0
TLS2_k127_4154241_3 flagellar assembly protein FliH K02411 - - 0.00000000000000000000000000000000000000001015 162.0
TLS2_k127_4154241_4 Flagellar hook-length control protein K02414 GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 - 0.000000000000000001348 96.0
TLS2_k127_4154241_5 Flagellar export protein FliJ K02413 - - 0.000005387 54.0
TLS2_k127_4155401_0 TIGRFAM penicillin-binding protein, 1A K05366 - 2.4.1.129,3.4.16.4 7.772e-247 788.0
TLS2_k127_4155401_1 Activates fatty acids by binding to coenzyme A K01897 - 6.2.1.3 2.205e-233 736.0
TLS2_k127_4155401_10 Zn-dependent protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 376.0
TLS2_k127_4155401_11 Pilus assembly protein K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 367.0
TLS2_k127_4155401_12 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001085 275.0
TLS2_k127_4155401_13 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000649 251.0
TLS2_k127_4155401_14 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000917 214.0
TLS2_k127_4155401_15 Pilus assembly protein PilO K02664 - - 0.00000000000000000000000000000000000000000000000000001076 196.0
TLS2_k127_4155401_16 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000000000000005414 192.0
TLS2_k127_4155401_17 mRNA catabolic process - - - 0.000000000000000000000000000000000000000000000000000639 191.0
TLS2_k127_4155401_18 PFAM Fimbrial assembly K02663 - - 0.00000000000000000000000000000000000000000000003456 176.0
TLS2_k127_4155401_19 pilus assembly protein pilp K02665 - - 0.00000000000000000000000000000000000000000006414 165.0
TLS2_k127_4155401_2 ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component K02004 - - 1.433e-213 692.0
TLS2_k127_4155401_20 50S ribosomal protein L31 K02909 - - 0.00000000000000000000000000002254 119.0
TLS2_k127_4155401_3 type IV pilus secretin PilQ K02666 - - 3.145e-202 652.0
TLS2_k127_4155401_4 Belongs to the citrate synthase family K01647 GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0036440,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350 2.3.3.1 6.152e-197 623.0
TLS2_k127_4155401_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 535.0
TLS2_k127_4155401_6 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 502.0
TLS2_k127_4155401_7 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 436.0
TLS2_k127_4155401_8 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 435.0
TLS2_k127_4155401_9 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009108 371.0
TLS2_k127_415817_0 Putative glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 519.0
TLS2_k127_415817_1 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 479.0
TLS2_k127_415817_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 425.0
TLS2_k127_415817_3 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000000000000008748 201.0
TLS2_k127_4180320_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 430.0
TLS2_k127_4180320_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 327.0
TLS2_k127_4180320_10 GAF domain - - - 0.0000000000000000002102 102.0
TLS2_k127_4180320_11 - - - - 0.000009778 56.0
TLS2_k127_4180320_2 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003345 276.0
TLS2_k127_4180320_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000002751 228.0
TLS2_k127_4180320_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000004264 215.0
TLS2_k127_4180320_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000003439 188.0
TLS2_k127_4180320_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000004367 194.0
TLS2_k127_4180320_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000004862 153.0
TLS2_k127_4180320_8 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000001204 146.0
TLS2_k127_4180320_9 Putative adhesin - - - 0.00000000000000000000000000000002309 141.0
TLS2_k127_4184727_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 309.0
TLS2_k127_4184727_1 Bacterial PH domain K08981 - - 0.0000000000000000000000000000000000000000000000000000000000003099 230.0
TLS2_k127_4184727_2 Bacterial PH domain K09167 - - 0.00000000000000002059 92.0
TLS2_k127_4191715_0 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 429.0
TLS2_k127_4191715_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008424 383.0
TLS2_k127_4191715_2 cytochrome oxidase assembly K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 325.0
TLS2_k127_4191715_3 SURF1-like protein - - - 0.000000000000000000000000000000000000000002746 166.0
TLS2_k127_4191715_4 signal sequence binding - - - 0.000000000000000000000000000000000005372 144.0
TLS2_k127_4191715_5 COG4767 Glycopeptide antibiotics resistance protein - - - 0.0000000000000000000000000000001845 138.0
TLS2_k127_4191715_6 Protein of unknown function (DUF2909) - - - 0.000000000002147 69.0
TLS2_k127_4191715_7 membrane K08985 - - 0.00007138 47.0
TLS2_k127_4197051_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 342.0
TLS2_k127_4197051_1 cytochrome C peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006027 289.0
TLS2_k127_4197051_2 COG3209 Rhs family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001136 267.0
TLS2_k127_4197051_3 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region - - - 0.00000000000000000000000000000000000000000000000000000000000000004166 246.0
TLS2_k127_4201615_0 Arginosuccinate synthase K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 392.0
TLS2_k127_4201615_1 Domain of unknown function (DUF1611_C) P-loop domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 295.0
TLS2_k127_4201615_2 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001417 282.0
TLS2_k127_4201615_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000003089 207.0
TLS2_k127_4201615_4 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.00000000000000000000000000000000000000002338 160.0
TLS2_k127_4201615_5 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000002347 100.0
TLS2_k127_4207990_0 Signal peptide peptidase K04773 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 448.0
TLS2_k127_4207990_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 437.0
TLS2_k127_4207990_2 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000001029 79.0
TLS2_k127_4238273_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 1.75e-208 656.0
TLS2_k127_4238273_1 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000002858 99.0
TLS2_k127_4238273_2 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K13010 - 2.6.1.102 0.00000002977 59.0
TLS2_k127_4241634_0 PFAM Glycosyl transferase, family 2 K11936 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 496.0
TLS2_k127_4241634_1 Diguanylate cyclase, GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000201 280.0
TLS2_k127_4241634_2 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000001034 199.0
TLS2_k127_4241634_3 TonB dependent receptor - - - 0.00000000000000000000000000000007559 136.0
TLS2_k127_4241634_4 PFAM secretion protein HlyD family protein - - - 0.000000000000000000000000001229 126.0
TLS2_k127_4245918_0 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 412.0
TLS2_k127_4245918_1 COG0471 Di- and tricarboxylate transporters - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 399.0
TLS2_k127_4253898_0 amidase activity K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 1.925e-225 718.0
TLS2_k127_4253898_1 Cupin 2, conserved barrel - - - 0.00000000000000000000000000000000000000000000000000006634 190.0
TLS2_k127_4253898_2 - - - - 0.0000000000000004177 84.0
TLS2_k127_426457_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0 1060.0
TLS2_k127_4271167_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 4.312e-277 863.0
TLS2_k127_4271167_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 3.672e-269 858.0
TLS2_k127_4271167_10 Peptidase M22 K14742 - - 0.000000000000000000000000000000000000000000009521 170.0
TLS2_k127_4271167_11 TIGRFAM conserved repeat domain - - - 0.000000000000004901 83.0
TLS2_k127_4271167_2 Helicase K03722 - 3.6.4.12 4.701e-197 638.0
TLS2_k127_4271167_3 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 624.0
TLS2_k127_4271167_4 Pkd domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 464.0
TLS2_k127_4271167_5 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 430.0
TLS2_k127_4271167_6 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007329 377.0
TLS2_k127_4271167_7 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 357.0
TLS2_k127_4271167_8 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 313.0
TLS2_k127_4271167_9 Forkhead associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000009549 229.0
TLS2_k127_4273316_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007872 247.0
TLS2_k127_4273316_1 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000001586 142.0
TLS2_k127_4273316_2 - - - - 0.0000000000000000001896 93.0
TLS2_k127_4301648_0 SMART Peptidoglycan-binding Lysin subgroup K16291 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007583 401.0
TLS2_k127_4301648_1 zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009846 371.0
TLS2_k127_4301648_2 Phage tail sheath C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001308 280.0
TLS2_k127_4315468_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 495.0
TLS2_k127_4315468_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 419.0
TLS2_k127_4315468_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 306.0
TLS2_k127_4315468_3 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001692 260.0
TLS2_k127_4315468_4 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000001571 190.0
TLS2_k127_4315468_5 membrane protein domain - - - 0.0000000000000000000000000000000000000000000004819 177.0
TLS2_k127_4315468_6 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000003742 145.0
TLS2_k127_4315468_7 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - 0.000000000000000000000001397 110.0
TLS2_k127_4315468_9 Tetratricopeptide TPR_2 repeat protein - - - 0.0001619 49.0
TLS2_k127_4325456_0 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000001603 101.0
TLS2_k127_4338878_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 478.0
TLS2_k127_4338878_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 332.0
TLS2_k127_4338878_2 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001458 271.0
TLS2_k127_4338878_3 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000001273 166.0
TLS2_k127_4339921_0 Dienelactone hydrolase family - - - 1.101e-282 882.0
TLS2_k127_4339921_1 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000001758 153.0
TLS2_k127_4339921_2 CcdB protein K19163 - - 0.00000000000000000000000000173 114.0
TLS2_k127_4339921_3 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid K19164 - - 0.0000000000000000001292 91.0
TLS2_k127_4339921_4 - - - - 0.000000000000002064 80.0
TLS2_k127_4339921_5 - - - - 0.00000000001615 72.0
TLS2_k127_4339921_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000002013 69.0
TLS2_k127_4349654_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 548.0
TLS2_k127_4349654_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 401.0
TLS2_k127_4349654_2 Domain of unknown function DUF21 K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 377.0
TLS2_k127_4349654_3 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 357.0
TLS2_k127_4349654_4 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 353.0
TLS2_k127_4349654_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009762 322.0
TLS2_k127_4349654_6 Preprotein translocase subunit YajC K03210 - - 0.00000000000000000000000000000000003095 138.0
TLS2_k127_4349654_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000007053 138.0
TLS2_k127_4349654_8 PDZ domain - - - 0.0000000000000000000006276 108.0
TLS2_k127_4361501_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 4.982e-252 807.0
TLS2_k127_4361501_1 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 602.0
TLS2_k127_4361501_2 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008647 383.0
TLS2_k127_4361501_3 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 313.0
TLS2_k127_4361501_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 288.0
TLS2_k127_4361501_5 enoyl-CoA hydratase K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001318 256.0
TLS2_k127_4361501_6 FCD - - - 0.0000000000000000000000000000000000000000001678 169.0
TLS2_k127_4361501_7 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 0.0000000000000000000000001617 107.0
TLS2_k127_4397021_0 Large extracellular alpha-helical protein K06894 - - 0.0 1584.0
TLS2_k127_4397021_1 Penicillin-Binding Protein C-terminus Family - - - 1.664e-269 850.0
TLS2_k127_4397021_2 Peptidase family M48 - - - 0.00000000000000000000000000000000000000004292 163.0
TLS2_k127_4401162_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 457.0
TLS2_k127_4401162_1 glycosyl transferase group 1 - - - 0.00000000000000000000000000001933 124.0
TLS2_k127_4401162_2 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000455 108.0
TLS2_k127_4405459_0 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 414.0
TLS2_k127_4405459_1 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001,K00344 - 1.1.1.1,1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 394.0
TLS2_k127_4405459_2 Protein of unknown function (DUF861) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 286.0
TLS2_k127_4405459_3 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 297.0
TLS2_k127_4405459_4 glyoxalase III activity K02005 - - 0.0000000000000000000000000000000000000000000000000000004559 201.0
TLS2_k127_4405459_5 transcriptional regulator, ArsR family - - - 0.000000000000000000000000000000000000000004278 157.0
TLS2_k127_4405459_6 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000000001739 158.0
TLS2_k127_4405459_7 acyl-CoA dehydrogenase activity - - - 0.0000000000008218 81.0
TLS2_k127_4405459_8 Putative esterase K07017 - - 0.000000006811 60.0
TLS2_k127_4405459_9 LytTr DNA-binding domain - - - 0.00001242 49.0
TLS2_k127_4418371_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214,K02438 - 3.2.1.196,3.2.1.68 7.531e-247 774.0
TLS2_k127_4418371_1 Domain of unknown function (DUF3459) K00700,K01236 - 2.4.1.18,3.2.1.141 1.002e-201 646.0
TLS2_k127_4422812_0 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 311.0
TLS2_k127_4422812_1 ATPases associated with a variety of cellular activities K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007919 306.0
TLS2_k127_4422812_2 PFAM Extracellular solute-binding protein, family 3 K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001793 279.0
TLS2_k127_4422812_3 polar amino acid ABC transporter, inner membrane subunit K02029,K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006475 285.0
TLS2_k127_4422812_4 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000004941 271.0
TLS2_k127_4422812_5 ABC transporter permease K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000006122 229.0
TLS2_k127_4444964_0 Beta-xylanase K01181 - 3.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000678 586.0
TLS2_k127_4444964_1 Tryptophan halogenase K14266 - 1.14.19.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 449.0
TLS2_k127_4444964_2 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002576 261.0
TLS2_k127_4495506_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 616.0
TLS2_k127_4495506_1 Belongs to the IlvD Edd family K01690 - 4.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 415.0
TLS2_k127_4499955_0 Sugar (and other) transporter K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004979 261.0
TLS2_k127_4499955_1 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 0.00000000000000000000000000002423 124.0
TLS2_k127_4499955_2 Methyl-transferase - - - 0.00000000000000000000000001171 113.0
TLS2_k127_4499955_3 - - - - 0.00000000003363 68.0
TLS2_k127_4499955_4 - - - - 0.00000000008091 64.0
TLS2_k127_4499955_5 Protein of unknown function (DUF2783) - - - 0.000000001225 62.0
TLS2_k127_4500489_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 351.0
TLS2_k127_4500489_1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000000000000000000004021 134.0
TLS2_k127_4500489_2 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.00000000000000000000000000000001187 130.0
TLS2_k127_4500815_0 TonB-dependent receptor - - - 5.071e-309 975.0
TLS2_k127_4500815_1 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685,K01708 - 4.2.1.42,4.2.1.7 3.842e-200 636.0
TLS2_k127_4500815_10 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000002936 195.0
TLS2_k127_4500815_11 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.0000000000000000000000000000000000000005416 155.0
TLS2_k127_4500815_2 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 597.0
TLS2_k127_4500815_3 PFAM Mannitol dehydrogenase K00040 - 1.1.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 570.0
TLS2_k127_4500815_4 Pectate lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 541.0
TLS2_k127_4500815_5 Pectate lyase K01728 - 4.2.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 439.0
TLS2_k127_4500815_6 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 388.0
TLS2_k127_4500815_7 C4-dicarboxylate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 366.0
TLS2_k127_4500815_8 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate K01815 - 5.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 313.0
TLS2_k127_4500815_9 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000004085 248.0
TLS2_k127_4508457_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001116 248.0
TLS2_k127_4508457_1 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000006979 190.0
TLS2_k127_4508457_2 Belongs to the UPF0235 family K09131 - - 0.00000000000000000003294 93.0
TLS2_k127_4512641_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 4.863e-218 695.0
TLS2_k127_4512641_1 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000002437 243.0
TLS2_k127_4512641_2 COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA K06169 - - 0.00000000000000000000000000000000000000000000000000003222 198.0
TLS2_k127_4512641_3 Colicin v production K03558 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - 0.0000000000000000000000836 104.0
TLS2_k127_4512641_4 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.000000000005141 66.0
TLS2_k127_4513291_0 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000001104 213.0
TLS2_k127_4513291_1 - - - - 0.00000000000000000000000000000000003868 143.0
TLS2_k127_4513291_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000003917 108.0
TLS2_k127_4513291_3 Protein of unknown function (DUF1648) - - - 0.000000000000006341 83.0
TLS2_k127_4521680_0 PFAM Pyrrolo-quinoline quinone K00114 - 1.1.2.8 0.0 1056.0
TLS2_k127_4521680_1 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 488.0
TLS2_k127_4521680_2 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000181 284.0
TLS2_k127_4521680_3 Bacterial regulatory protein, Fis family K21405 - - 0.0000000000000000000000000000000000000000001179 165.0
TLS2_k127_4521680_4 - - - - 0.0000000000000000000000000000001483 127.0
TLS2_k127_452916_0 Periplasmic binding protein domain K01999 - - 5.682e-216 672.0
TLS2_k127_452916_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006682 501.0
TLS2_k127_452916_2 short chain amide porin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009982 398.0
TLS2_k127_452916_3 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K11959 - - 0.00000000001765 70.0
TLS2_k127_4538322_0 AMP-binding enzyme K12508 - 6.2.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 625.0
TLS2_k127_4538322_1 PFAM amidohydrolase 2 K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 463.0
TLS2_k127_4538322_2 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 408.0
TLS2_k127_4538322_3 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001236 254.0
TLS2_k127_4545773_0 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002353 276.0
TLS2_k127_4545773_1 histidine kinase HAMP region domain protein K07640 - 2.7.13.3 0.0000001316 53.0
TLS2_k127_4581023_0 Acyltransferase family K11941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009047 274.0
TLS2_k127_4581023_1 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000001938 123.0
TLS2_k127_4582621_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 451.0
TLS2_k127_4582621_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 321.0
TLS2_k127_4582621_2 belongs to the histidinol- phosphatase family K01089 - 3.1.3.15,4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000003406 222.0
TLS2_k127_45881_0 Dipeptidyl carboxypeptidase K01284 - 3.4.15.5 1.439e-288 899.0
TLS2_k127_45881_1 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772,K03773 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000006276 247.0
TLS2_k127_45881_2 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000000000000000002736 209.0
TLS2_k127_4588306_0 MatE - - - 2.53e-198 622.0
TLS2_k127_4588306_1 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 466.0
TLS2_k127_4588306_2 MgtE intracellular N domain K06213 - - 0.00000457 57.0
TLS2_k127_4599650_0 DNA ligase K01971 - 6.5.1.1 0.0 1152.0
TLS2_k127_4599650_1 acyl-CoA dehydrogenase activity K09456 - - 1.007e-198 635.0
TLS2_k127_4599650_2 Cysteine-rich secretory protein family - - - 0.00000000000000000000000000000000000000000000000000000001218 211.0
TLS2_k127_4599935_0 succinyl-diaminopimelate desuccinylase activity K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 432.0
TLS2_k127_4599935_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004143 278.0
TLS2_k127_4599935_2 - - - - 0.00000000000000000000000000000000000000000000000000000002102 211.0
TLS2_k127_4599935_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000001392 154.0
TLS2_k127_4599935_4 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000006239 109.0
TLS2_k127_460102_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 332.0
TLS2_k127_460102_1 Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000002128 209.0
TLS2_k127_460891_0 TonB dependent receptor - - - 1.451e-245 780.0
TLS2_k127_460891_1 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 554.0
TLS2_k127_460891_2 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005523 497.0
TLS2_k127_4616987_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 395.0
TLS2_k127_4616987_1 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000000000004137 170.0
TLS2_k127_4616987_2 - - - - 0.000000000000000000000000000001792 134.0
TLS2_k127_4622546_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 7.342e-220 694.0
TLS2_k127_4622546_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 556.0
TLS2_k127_4622546_2 Phospholipase D Active site motif K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009549 375.0
TLS2_k127_4622546_3 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004731 303.0
TLS2_k127_4622546_4 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000003506 199.0
TLS2_k127_4622546_5 UPF0391 membrane protein - - - 0.000000000003485 72.0
TLS2_k127_4622546_6 - - - - 0.000001102 55.0
TLS2_k127_4622546_7 - - - - 0.0003269 51.0
TLS2_k127_4623090_0 aminopeptidase N - - - 0.00000000000000000000000000000000000000000000000000000000000000000001718 249.0
TLS2_k127_4623090_1 Alpha/beta hydrolase family K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000001446 224.0
TLS2_k127_4624455_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 2096.0
TLS2_k127_4624455_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1250.0
TLS2_k127_4624455_2 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 326.0
TLS2_k127_4624455_3 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004359 293.0
TLS2_k127_4624455_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000005969 245.0
TLS2_k127_4624455_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000002461 224.0
TLS2_k127_4624455_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000001527 170.0
TLS2_k127_4624455_7 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00000000000000000000000007575 110.0
TLS2_k127_4629783_0 Amidase - - - 1.27e-234 750.0
TLS2_k127_4629783_1 amidase activity K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 478.0
TLS2_k127_4651360_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 9.133e-252 779.0
TLS2_k127_4651360_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.885e-213 672.0
TLS2_k127_4651360_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 313.0
TLS2_k127_4651360_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000009697 260.0
TLS2_k127_4651360_4 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000003027 239.0
TLS2_k127_4651360_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.00000000000000000000000000000000000000000000000008777 179.0
TLS2_k127_4651360_6 Preprotein translocase subunit SecG K03075 - - 0.000000000000000000003341 97.0
TLS2_k127_4651360_7 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 0.000000000001063 71.0
TLS2_k127_4659148_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 573.0
TLS2_k127_4659148_1 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.0000000000001833 76.0
TLS2_k127_469624_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 3.217e-267 868.0
TLS2_k127_469624_1 WD40-like Beta Propeller Repeat - - - 8.849e-211 667.0
TLS2_k127_469624_2 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 522.0
TLS2_k127_469624_3 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 486.0
TLS2_k127_469624_4 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000000000000000000000004609 208.0
TLS2_k127_469624_5 Transfers electrons from cytochrome c551 to cytochrome oxidase - - - 0.0000000000000000000000000000000000000000000000004992 179.0
TLS2_k127_469624_6 BON domain K04065 - - 0.0000000000000001275 87.0
TLS2_k127_469624_7 Reduces the stability of FtsZ polymers in the presence of ATP K06916 - - 0.000000000007069 66.0
TLS2_k127_4718624_0 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008646 376.0
TLS2_k127_4718624_1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 349.0
TLS2_k127_4718624_2 pteridine-dependent deoxygenase K18240 - 4.1.3.40,4.1.3.45 0.000000000000000000000000000000000000000000000000000000009244 203.0
TLS2_k127_4718624_3 PFAM monooxygenase FAD-binding - - - 0.0000000000000000000000000002416 115.0
TLS2_k127_472748_0 aldo keto reductase K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 341.0
TLS2_k127_472748_1 Water Stress and Hypersensitive response - - - 0.00000000000000000000000000000000000000000000000002742 183.0
TLS2_k127_472748_2 Dodecin K09165 - - 0.00000000000000000000003438 101.0
TLS2_k127_472748_3 - - - - 0.0000000000000552 80.0
TLS2_k127_472748_4 - - - - 0.000001735 54.0
TLS2_k127_4735444_0 PFAM Integrase, catalytic K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006112 256.0
TLS2_k127_4735444_1 PFAM transposase, mutator K07493 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002098 257.0
TLS2_k127_4735444_2 - - - - 0.00000000000000000000000000004078 117.0
TLS2_k127_4735444_3 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000000000000000000000003727 118.0
TLS2_k127_4735444_4 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.000000000000000000007216 106.0
TLS2_k127_4735444_5 PFAM transposase, mutator K07493 - - 0.000000000000000002097 89.0
TLS2_k127_4735444_6 ParE toxin of type II toxin-antitoxin system, parDE K19092 - - 0.000000000000002532 88.0
TLS2_k127_4735444_7 PFAM Transposase IS3 IS911family K07483 - - 0.0000000000000811 78.0
TLS2_k127_4735444_8 belongs to the thioredoxin family - - - 0.0000007089 57.0
TLS2_k127_4735444_9 PFAM transposase IS116 IS110 IS902 family protein - - - 0.000001098 57.0
TLS2_k127_4739001_0 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 342.0
TLS2_k127_4739001_1 6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000002312 224.0
TLS2_k127_4739001_2 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000001195 173.0
TLS2_k127_4739001_3 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000001251 122.0
TLS2_k127_4739001_4 - - - - 0.000006884 49.0
TLS2_k127_4740179_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 5.702e-256 797.0
TLS2_k127_4740179_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 6.515e-210 677.0
TLS2_k127_4740179_2 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 496.0
TLS2_k127_4740179_3 signal transduction histidine kinase K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 353.0
TLS2_k127_4740179_4 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000007778 182.0
TLS2_k127_4740179_5 Domain of unknown function (DUF4124) - - - 0.000000000000009192 83.0
TLS2_k127_4740294_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 539.0
TLS2_k127_4740294_1 OmpA family - - - 0.00000005827 63.0
TLS2_k127_4744756_0 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 509.0
TLS2_k127_4744756_1 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 336.0
TLS2_k127_4744756_2 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 329.0
TLS2_k127_4744756_3 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - 0.000000000000005147 77.0
TLS2_k127_4744756_4 - - - - 0.000000002365 61.0
TLS2_k127_4770332_0 chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 381.0
TLS2_k127_4770332_1 heme binding - - - 0.0000000000000000000000000000000000000000000000000000000006709 222.0
TLS2_k127_4770332_2 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000009552 196.0
TLS2_k127_4770332_3 esterase K12686 - - 0.000000000000000000000000000000000000000006294 171.0
TLS2_k127_4776561_0 glucose galactose transporter K02429 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 521.0
TLS2_k127_4776561_1 PFAM Extensin family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002487 280.0
TLS2_k127_4776561_2 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005172 259.0
TLS2_k127_4776561_3 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000563 207.0
TLS2_k127_4776561_4 Transglycosylase associated protein - - - 0.000000000000000000000000000000000007251 137.0
TLS2_k127_4776561_5 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 3.1.31.1 0.00000000000000000000000000004126 125.0
TLS2_k127_4781112_0 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 515.0
TLS2_k127_4781112_1 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 472.0
TLS2_k127_4781112_2 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009748 327.0
TLS2_k127_4781112_3 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000209 275.0
TLS2_k127_4781112_4 Hydrolase K20881 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000002771 248.0
TLS2_k127_4781112_5 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000000000000000000000002425 166.0
TLS2_k127_4781112_6 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000000000000000000000000000000000000004254 151.0
TLS2_k127_4781112_7 peptide chain release factor K15034 - - 0.000000000000000000000000000000000001264 143.0
TLS2_k127_4781112_8 small protein containing a coiled-coil domain - - - 0.000000000000002961 77.0
TLS2_k127_4781112_9 Protein of unknown function (DUF3301) - - - 0.0000000000004797 76.0
TLS2_k127_4783150_0 lysine biosynthetic process via aminoadipic acid - - - 1.526e-319 997.0
TLS2_k127_4783150_1 PQQ-like domain K00117 - 1.1.5.2 2.49e-240 755.0
TLS2_k127_4783150_2 Sir2 family K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004092 279.0
TLS2_k127_4783150_3 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000009194 225.0
TLS2_k127_4783150_4 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000002601 186.0
TLS2_k127_4783150_5 PEP-CTERM motif - - - 0.00000000000000000000000000000000000408 146.0
TLS2_k127_4783150_6 regulation of single-species biofilm formation - - - 0.00000000000000001483 85.0
TLS2_k127_4788740_0 Amidohydrolase family K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 435.0
TLS2_k127_4788740_1 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 392.0
TLS2_k127_4788740_2 Major Facilitator Superfamily - - - 0.000000001181 61.0
TLS2_k127_4795494_0 RHS Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007525 292.0
TLS2_k127_4837264_0 SMART Nucleotide binding protein, PINc K07175 - - 4.498e-212 672.0
TLS2_k127_4837264_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 372.0
TLS2_k127_4837264_2 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000007017 256.0
TLS2_k127_4837264_3 PFAM Amino acid-binding ACT K03567 - - 0.0000000000000000000000000000000000000000000000000000000008775 205.0
TLS2_k127_4837264_4 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000001615 202.0
TLS2_k127_4864471_0 OmpA family K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 449.0
TLS2_k127_4864471_1 MotA TolQ ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 418.0
TLS2_k127_4864471_2 Acetyltransferase (GNAT) domain K03827 - - 0.00000000000000000000000000000000000000000002016 166.0
TLS2_k127_4864471_3 Protein of unknown function, DUF393 - - - 0.00009106 46.0
TLS2_k127_4876680_0 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 0.0 1255.0
TLS2_k127_4876680_1 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 5.664e-205 651.0
TLS2_k127_4876680_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000004865 137.0
TLS2_k127_4879134_0 FAD linked oxidase domain protein K05797 - 1.17.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007868 560.0
TLS2_k127_4879134_1 - - - - 0.0000000000000000001145 95.0
TLS2_k127_4879134_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000006756 70.0
TLS2_k127_4880075_0 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 574.0
TLS2_k127_4880075_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 479.0
TLS2_k127_4880075_10 pfam ammecr1 - - - 0.000000000000000000000000000000000000000000000000005893 190.0
TLS2_k127_4880075_11 - - - - 0.000000000000000000000000000000000000000000003893 181.0
TLS2_k127_4880075_12 - - - - 0.0000000000000000000000000000000000000000003286 171.0
TLS2_k127_4880075_13 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000501 161.0
TLS2_k127_4880075_14 - - - - 0.0000000000000000000000006768 120.0
TLS2_k127_4880075_15 - - - - 0.000000000000000001718 96.0
TLS2_k127_4880075_16 Radical SAM K04069 - 1.97.1.4 0.00000000001309 66.0
TLS2_k127_4880075_17 - - - - 0.00000000001905 77.0
TLS2_k127_4880075_2 DNA repair photolyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 432.0
TLS2_k127_4880075_3 Secreted protein, containing von Willebrand factor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 366.0
TLS2_k127_4880075_4 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 317.0
TLS2_k127_4880075_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 323.0
TLS2_k127_4880075_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001418 293.0
TLS2_k127_4880075_7 Pfam MotA TolQ ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007646 274.0
TLS2_k127_4880075_8 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003065 266.0
TLS2_k127_4880075_9 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000008269 224.0
TLS2_k127_4883494_0 carboxylic ester hydrolase activity - - - 8.421e-196 646.0
TLS2_k127_4883494_1 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000000000000000000009684 175.0
TLS2_k127_4892472_0 transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000003471 192.0
TLS2_k127_4892472_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000002202 175.0
TLS2_k127_4892472_2 DNA integration - - - 0.000000000000000000000000000000000005561 140.0
TLS2_k127_4892472_4 - - - - 0.00000004816 58.0
TLS2_k127_4895538_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 576.0
TLS2_k127_4895538_1 PFAM Enoyl-CoA hydratase isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004161 274.0
TLS2_k127_4912539_0 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 - 6.4.1.1 0.0 1110.0
TLS2_k127_4913485_0 ATPase components of ABC transporters with duplicated ATPase domains K15738 - - 8.261e-204 651.0
TLS2_k127_4913485_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 391.0
TLS2_k127_4913485_2 - - - - 0.000000000000000000000000000000000000007754 151.0
TLS2_k127_4916921_0 transposition, DNA-mediated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 306.0
TLS2_k127_4916921_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000191 115.0
TLS2_k127_4927652_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1449.0
TLS2_k127_4927652_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004273 372.0
TLS2_k127_4927652_2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000001167 168.0
TLS2_k127_4927652_3 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000005248 114.0
TLS2_k127_4927652_4 Choline/ethanolamine kinase - - - 0.000000000000000000206 97.0
TLS2_k127_4932696_0 Isocitrate dehydrogenase - - - 1.09e-223 700.0
TLS2_k127_4932696_1 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002484 273.0
TLS2_k127_4932696_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002992 252.0
TLS2_k127_4932696_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000116 178.0
TLS2_k127_4932696_4 Protein of unknown function (DUF2905) - - - 0.000000000000000000000008633 101.0
TLS2_k127_4932696_5 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.0000122 48.0
TLS2_k127_4939873_0 Efflux pump membrane transporter K18138 - - 0.0 1197.0
TLS2_k127_4939873_1 RND efflux system, outer membrane K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 323.0
TLS2_k127_4939873_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 304.0
TLS2_k127_4939873_3 Bacterial protein of unknown function (DUF924) - - - 0.0000000000000000000000000000000000000000000000000000007278 199.0
TLS2_k127_4939873_4 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000001256 111.0
TLS2_k127_4939873_5 PilZ domain - - - 0.000007932 53.0
TLS2_k127_4950285_0 Histidine Phosphotransfer domain K11527 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 495.0
TLS2_k127_4952342_0 trisaccharide binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 631.0
TLS2_k127_4952342_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 623.0
TLS2_k127_4952342_2 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 434.0
TLS2_k127_4952342_3 Beta-lactamase - - - 0.00000000000000000000000000000000000000000002842 168.0
TLS2_k127_4952342_4 RES - - - 0.000000001866 63.0
TLS2_k127_495528_0 Protein involved in outer membrane biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007212 451.0
TLS2_k127_495528_1 PFAM Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 317.0
TLS2_k127_4956742_0 Pathogenicity protein K09800 - - 2.367e-263 854.0
TLS2_k127_4956742_1 Glucose / Sorbosone dehydrogenase - - - 1.072e-199 632.0
TLS2_k127_4956742_2 membrane K07278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000716 506.0
TLS2_k127_4956742_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 449.0
TLS2_k127_4956742_4 L-lactate permease K03303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 349.0
TLS2_k127_4956742_5 Universal stress protein family K14055 - - 0.0000000000000000000000000000000005235 143.0
TLS2_k127_4957103_0 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009868 559.0
TLS2_k127_4957103_1 Amino acid permease K03294,K16238 - - 0.000000000000000000000000000000000000000000000000001789 192.0
TLS2_k127_4957103_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000003788 183.0
TLS2_k127_4957103_3 membrane - - - 0.0000000000000000000000000000000000000001378 154.0
TLS2_k127_4987657_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 6.48e-265 820.0
TLS2_k127_4987657_1 COG2217 Cation transport ATPase K01533 - 3.6.3.4 1.646e-206 675.0
TLS2_k127_4987657_2 TIGRFAM cytochrome c oxidase accessory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 573.0
TLS2_k127_4987657_3 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 327.0
TLS2_k127_4987657_4 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 305.0
TLS2_k127_4987657_5 - - - - 0.00000000005356 66.0
TLS2_k127_4987657_6 Cytochrome oxidase maturation protein - - - 0.0000000003755 63.0
TLS2_k127_4987657_7 Cbb3-type cytochrome oxidase K00407 - - 0.00000001584 60.0
TLS2_k127_4995023_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 430.0
TLS2_k127_4995023_1 Transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 340.0
TLS2_k127_4995023_2 ATPases associated with a variety of cellular activities K05776 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008305 287.0
TLS2_k127_4995023_3 Signal transduction protein - - - 0.000000000000000000000000000000000000000005086 169.0
TLS2_k127_4995023_4 Domain of unknown function (DUF1840) - - - 0.000000000000000001584 89.0
TLS2_k127_4995023_5 CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.0000000009374 59.0
TLS2_k127_5005528_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 433.0
TLS2_k127_5005528_1 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 354.0
TLS2_k127_5027398_0 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 554.0
TLS2_k127_5027398_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004678 516.0
TLS2_k127_5027398_2 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 511.0
TLS2_k127_5027398_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002461 224.0
TLS2_k127_5027398_4 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.0000000000000000000000000000000000000000000000000001189 187.0
TLS2_k127_5027398_5 Protein of unknown function (DUF1778) - - - 0.000000000000000000000000002373 114.0
TLS2_k127_5027398_6 belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000004631 92.0
TLS2_k127_5027445_0 Extracellular solute-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 430.0
TLS2_k127_5027445_1 ATPase activity K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 395.0
TLS2_k127_5027445_2 AAA-like domain - - - 0.000000000000000000000000000000000000000000002038 166.0
TLS2_k127_50371_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.635e-203 639.0
TLS2_k127_50371_1 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 307.0
TLS2_k127_50371_2 TIGRFAM Polyhydroxyalkanoate synthesis repressor PhaR - - - 0.0000000000000000000000000000000000000189 149.0
TLS2_k127_5050408_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005889 311.0
TLS2_k127_5050408_1 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000001299 226.0
TLS2_k127_5057272_0 Saccharopine dehydrogenase NADP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 362.0
TLS2_k127_5057272_1 cheY-homologous receiver domain - - - 0.00000000000004531 82.0
TLS2_k127_5081079_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 458.0
TLS2_k127_5081079_1 deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008997 306.0
TLS2_k127_5081079_2 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000003585 206.0
TLS2_k127_5081079_3 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000005879 202.0
TLS2_k127_5081079_4 - - - - 0.0000000000000000000000000000000000000000003927 174.0
TLS2_k127_5081079_5 COG3279 Response regulator of the LytR AlgR family K02477 - - 0.00000000000000000000000000000000001416 148.0
TLS2_k127_5084872_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 453.0
TLS2_k127_5084872_1 Serine threonine protein kinase involved in cell cycle control - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 354.0
TLS2_k127_5084872_2 Protein of unknown function (DUF3037) - - - 0.0000000000000000000000000000000000000000000000002887 178.0
TLS2_k127_5084872_3 Outer membrane protein W K07275 - - 0.0000000000000000000000000000000000000000009979 162.0
TLS2_k127_5085103_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 1.827e-202 657.0
TLS2_k127_5085103_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 462.0
TLS2_k127_5085103_10 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004201 254.0
TLS2_k127_5085103_11 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.00000000000000000000000000000000000000000000000000000002668 208.0
TLS2_k127_5085103_12 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000006051 190.0
TLS2_k127_5085103_13 Belongs to the skp family K06142 - - 0.00000000000000000000000000000002262 132.0
TLS2_k127_5085103_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 456.0
TLS2_k127_5085103_3 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 409.0
TLS2_k127_5085103_4 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 379.0
TLS2_k127_5085103_5 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 354.0
TLS2_k127_5085103_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 344.0
TLS2_k127_5085103_7 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 340.0
TLS2_k127_5085103_8 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 329.0
TLS2_k127_5085103_9 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003436 284.0
TLS2_k127_5113845_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 7.909e-210 660.0
TLS2_k127_5113845_1 Protein tyrosine kinase K08282,K11916,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001306 292.0
TLS2_k127_5113845_2 Forkhead associated domain K11894 - - 0.0000000000000000000000000000000000000000000000000000000000006962 227.0
TLS2_k127_5113845_3 SMART protein phosphatase 2C domain protein K01090 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000008429 192.0
TLS2_k127_5113845_4 glyoxalase III activity - - - 0.00000000000001108 81.0
TLS2_k127_5133194_0 Protein of unknown function (DUF1134) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004769 265.0
TLS2_k127_5133194_1 Pfam Transposase IS66 - - - 0.000000000000000000000000000000000000000000000000000000000002117 220.0
TLS2_k127_5133194_2 YHS domain protein - - - 0.0000000000001918 73.0
TLS2_k127_5159812_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 310.0
TLS2_k127_5159812_1 NADPH-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 287.0
TLS2_k127_5159812_2 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000008255 80.0
TLS2_k127_5159812_3 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.0000000000000009873 82.0
TLS2_k127_5165729_0 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006071 619.0
TLS2_k127_5165729_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 533.0
TLS2_k127_5165729_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 407.0
TLS2_k127_5165729_3 Exodeoxyribonuclease IX - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004817 308.0
TLS2_k127_5165729_4 Fructosamine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 295.0
TLS2_k127_5165729_5 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000006828 215.0
TLS2_k127_5165729_6 YCII-related domain K09780 - - 0.00000000000000000000000000000005172 131.0
TLS2_k127_5165729_7 Belongs to the UPF0312 family - - - 0.000005166 48.0
TLS2_k127_5165729_8 - - - - 0.0002845 49.0
TLS2_k127_5171251_0 PFAM 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.226e-212 680.0
TLS2_k127_5171251_1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 354.0
TLS2_k127_5171251_2 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002093 280.0
TLS2_k127_5171251_3 Pilus assembly protein PilZ K02676 - - 0.0000000000000000000005511 95.0
TLS2_k127_5171251_4 Domain of unknown function (DUF4168) - - - 0.00006939 52.0
TLS2_k127_5171251_6 conjugal transfer protein traA - - - 0.000359 49.0
TLS2_k127_5171515_0 Outer membrane receptor - - - 1.305e-202 646.0
TLS2_k127_5171515_1 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 588.0
TLS2_k127_5171515_2 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000001638 195.0
TLS2_k127_517317_0 COG1613 ABC-type sulfate transport system, periplasmic component K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 486.0
TLS2_k127_517317_1 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 404.0
TLS2_k127_517317_2 Phosphate-selective porin O and P K07221 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 351.0
TLS2_k127_517317_3 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007131 285.0
TLS2_k127_517317_4 Peptidoglycan-binding domain-containing protein K17733 - - 0.000000000000000000000000000000000007875 148.0
TLS2_k127_5179403_0 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009609 549.0
TLS2_k127_5196911_0 FRG domain - - - 0.00000000000000000000000000000000001612 150.0
TLS2_k127_5196911_1 Pyridoxal-phosphate dependent enzyme K01697,K01738 - 2.5.1.47,4.2.1.22 0.00000000000000000000000247 102.0
TLS2_k127_5198621_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008947 548.0
TLS2_k127_5198621_1 Domain of unknown function (DUF4398) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002233 274.0
TLS2_k127_5198621_2 redox protein, regulator of disulfide bond formation - - - 0.0000000000000000000000000000000000000000157 158.0
TLS2_k127_5198621_3 Domain of unknown function (DUF4398) - - - 0.0008684 44.0
TLS2_k127_5208711_0 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.0000000000000000000000000000000000000000001211 163.0
TLS2_k127_5208711_1 - - - - 0.000000000000000000000000000000001451 136.0
TLS2_k127_5208711_2 PFAM phosphoesterase PA-phosphatase related K19302 - 3.6.1.27 0.000000000000000000000000000005428 126.0
TLS2_k127_5208711_3 Methyltransferase domain - - - 0.0000000000000000000000000005323 116.0
TLS2_k127_5208711_4 Belongs to the UPF0270 family K09898 - - 0.00000000000001158 77.0
TLS2_k127_5208711_5 - - - - 0.0000000009505 67.0
TLS2_k127_5211328_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 526.0
TLS2_k127_5211328_1 Autotransporter beta-domain - - - 0.00000007454 61.0
TLS2_k127_5259551_0 biogenesis protein K09792 - - 0.000000000000000000000000000000000000002297 156.0
TLS2_k127_5259551_1 transcription elongation factor GreA GreB K06140 - - 0.000000000000000000000000000005428 126.0
TLS2_k127_5259551_2 Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0003533 51.0
TLS2_k127_5273467_0 WYL domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002668 280.0
TLS2_k127_5273467_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000004455 225.0
TLS2_k127_5273467_2 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.000000000000000000000000000000000000000000001251 169.0
TLS2_k127_5273467_3 - - - - 0.000000005027 61.0
TLS2_k127_5273467_4 Bacterial protein of unknown function (DUF839) K07093 - - 0.000008596 49.0
TLS2_k127_527918_0 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 290.0
TLS2_k127_527918_1 Lipid A biosynthesis K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004617 285.0
TLS2_k127_527918_2 Lipid A biosynthesis K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000004885 233.0
TLS2_k127_5280739_0 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 357.0
TLS2_k127_5280739_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000001792 252.0
TLS2_k127_5280739_2 periplasmic protein - - - 0.00000000000000000000000000000001456 137.0
TLS2_k127_5280739_3 Regulator of chromosome condensation (RCC1) repeat - - - 0.0000000000000000002069 102.0
TLS2_k127_5280739_4 beta-lactamase K06897 - 2.5.1.105 0.0000000000000001869 81.0
TLS2_k127_5280739_5 Fic/DOC family - - - 0.0000009685 50.0
TLS2_k127_5280739_6 alkaline phosphatase - - - 0.000002003 55.0
TLS2_k127_5280996_0 AAA domain - - - 0.00000000000000000000000000000000000000000000000001145 190.0
TLS2_k127_5280996_1 protein involved in exopolysaccharide biosynthesis - - - 0.000000000000000000000000000000000000000000001745 185.0
TLS2_k127_5280996_2 Protein conserved in bacteria - - - 0.00000006227 64.0
TLS2_k127_5288708_0 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004573 583.0
TLS2_k127_5289023_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 601.0
TLS2_k127_5289023_1 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.3.1.29 0.000000000000000000000000009148 111.0
TLS2_k127_5289023_2 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.0000000000000000000000005858 108.0
TLS2_k127_529047_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.68e-239 761.0
TLS2_k127_529047_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 2.945e-203 642.0
TLS2_k127_529047_10 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 347.0
TLS2_k127_529047_11 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 347.0
TLS2_k127_529047_12 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 317.0
TLS2_k127_529047_13 phosphatase K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 287.0
TLS2_k127_529047_14 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001131 281.0
TLS2_k127_529047_15 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002381 273.0
TLS2_k127_529047_16 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005397 267.0
TLS2_k127_529047_17 (FHA) domain - - - 0.00000000000000000000000000000000000000000000000000000000000002264 224.0
TLS2_k127_529047_18 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000001065 184.0
TLS2_k127_529047_19 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000000000038 176.0
TLS2_k127_529047_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 604.0
TLS2_k127_529047_20 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000001013 145.0
TLS2_k127_529047_21 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000000000003231 137.0
TLS2_k127_529047_22 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000002964 136.0
TLS2_k127_529047_23 membrane - - - 0.000000000000000001018 97.0
TLS2_k127_529047_24 protein conserved in bacteria K09937 - - 0.0000000000001084 72.0
TLS2_k127_529047_3 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008145 565.0
TLS2_k127_529047_4 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 544.0
TLS2_k127_529047_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 519.0
TLS2_k127_529047_6 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 511.0
TLS2_k127_529047_7 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 530.0
TLS2_k127_529047_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 484.0
TLS2_k127_529047_9 Cell wall hydrolase autolysin K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 372.0
TLS2_k127_5292528_0 Beta-lactamase - - - 1.457e-216 688.0
TLS2_k127_5292528_1 inositol 2-dehydrogenase activity - - - 0.0000000000000000000008665 100.0
TLS2_k127_52972_0 Peptidase family M1 domain - - - 3.169e-320 1008.0
TLS2_k127_52972_1 ABC transporter - - - 0.000000000000000000000000000000000000000000000000003827 184.0
TLS2_k127_5300999_0 Major facilitator Superfamily K05939 - 2.3.1.40,6.2.1.20 1.543e-217 694.0
TLS2_k127_5300999_1 Two component signalling adaptor domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 581.0
TLS2_k127_5300999_10 Domain of unknown function (DUF4252) - - - 0.000000000000000000000000000005402 129.0
TLS2_k127_5300999_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 480.0
TLS2_k127_5300999_3 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 397.0
TLS2_k127_5300999_4 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001886 237.0
TLS2_k127_5300999_5 tellurite resistance protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009552 232.0
TLS2_k127_5300999_6 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000002253 220.0
TLS2_k127_5300999_7 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000001021 183.0
TLS2_k127_5300999_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000011 145.0
TLS2_k127_5300999_9 Aldo Keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000003609 123.0
TLS2_k127_5327449_0 Belongs to the flagella basal body rod proteins family K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 471.0
TLS2_k127_5327449_1 Flagellar rod assembly protein muramidase FlgJ K02395 - - 0.0000000000000000000000000000000000000000000000000005991 189.0
TLS2_k127_5332574_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008801 286.0
TLS2_k127_5332574_1 transferase activity, transferring glycosyl groups K16703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002378 276.0
TLS2_k127_5332574_2 deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000009365 246.0
TLS2_k127_5332574_3 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000002513 193.0
TLS2_k127_5332574_4 ATP-grasp - - - 0.0000000000000000005891 92.0
TLS2_k127_5343587_0 PFAM Peptidase family M48 K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006199 460.0
TLS2_k127_5343587_1 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006812 272.0
TLS2_k127_5343587_2 Protein of unknown function (DUF938) - - - 0.00000000000000000000000000000000000000000000000000000000000000001331 231.0
TLS2_k127_5343587_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000003958 214.0
TLS2_k127_5343587_4 Protein of unknown function (DUF1249) K09920 - - 0.00000000000000000000000000344 117.0
TLS2_k127_5379010_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 427.0
TLS2_k127_5379010_1 MarR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 335.0
TLS2_k127_5379010_2 and related - - - 0.0000000000000000001787 92.0
TLS2_k127_5379010_3 and related - - - 0.000000000000000009972 85.0
TLS2_k127_5390039_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 3.097e-262 814.0
TLS2_k127_5390039_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 8.782e-228 736.0
TLS2_k127_5390039_10 biopolymer transport protein - - - 0.0000000000000000000000000000000000000002463 157.0
TLS2_k127_5390039_11 Biopolymer transport protein ExbD/TolR - - - 0.0000000000000000000000000000000001716 138.0
TLS2_k127_5390039_12 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000009476 119.0
TLS2_k127_5390039_13 TPR repeat - - - 0.000000000000000000000000001331 127.0
TLS2_k127_5390039_14 - - - - 0.0000000000000001041 86.0
TLS2_k127_5390039_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.31e-203 644.0
TLS2_k127_5390039_3 pfkB family carbohydrate kinase K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004437 449.0
TLS2_k127_5390039_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 443.0
TLS2_k127_5390039_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 383.0
TLS2_k127_5390039_6 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006304 270.0
TLS2_k127_5390039_7 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000000000000000000000000000000000000000000000000000001009 209.0
TLS2_k127_5390039_8 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000003186 176.0
TLS2_k127_5390039_9 Histidine kinase K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000002972 177.0
TLS2_k127_5392827_0 Transfers the fatty acyl group on membrane lipoproteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003012 370.0
TLS2_k127_5392827_1 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000107 207.0
TLS2_k127_5392827_2 Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool K06019 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.1 0.00000000000000000006313 98.0
TLS2_k127_5392827_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000001632 70.0
TLS2_k127_5392827_4 Extracellular repeat protein, HAF family - - - 0.000002481 59.0
TLS2_k127_5393296_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1017.0
TLS2_k127_5393296_1 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 449.0
TLS2_k127_5393296_2 Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000000000000001702 185.0
TLS2_k127_5393296_3 pfam nlp p60 K13695 - - 0.00000000000000000000000000000000484 133.0
TLS2_k127_5393296_5 troponin C - GO:0003674,GO:0005488,GO:0005515,GO:0008092,GO:0031013 - 0.00000003111 57.0
TLS2_k127_5402124_0 oxidoreductase K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 564.0
TLS2_k127_5402124_1 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001098 275.0
TLS2_k127_5402124_2 Carboxylesterase family - - - 0.000000000000000000000000000000000000000000000002679 184.0
TLS2_k127_5402124_3 Protein of unknown function (DUF2459) - - - 0.00000000000000000000000001941 117.0
TLS2_k127_5402124_4 Protein of unknown function (DUF4242) - - - 0.000000249 61.0
TLS2_k127_5428213_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 500.0
TLS2_k127_5428213_1 citrate synthase K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 339.0
TLS2_k127_5428213_2 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 311.0
TLS2_k127_5428213_3 helix_turn_helix isocitrate lyase regulation K02624 - - 0.000000000000000000000000000000000000000000000000000000001129 210.0
TLS2_k127_5436717_0 TonB dependent receptor - - - 0.0 1131.0
TLS2_k127_5436717_1 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000002171 226.0
TLS2_k127_5436717_2 Protein of unknown function (DUF3738) - - - 0.000000000000000000000000000000000000000000000009133 184.0
TLS2_k127_5436717_3 Protein of unknown function (DUF1653) - - - 0.00000000000000000000004846 102.0
TLS2_k127_5450411_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 411.0
TLS2_k127_5450411_1 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 396.0
TLS2_k127_5450614_0 receptor - - - 4.924e-210 679.0
TLS2_k127_5450614_1 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 285.0
TLS2_k127_5450614_2 regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000398 252.0
TLS2_k127_5450614_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001513 252.0
TLS2_k127_5455023_0 Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05559 - - 9.698e-265 831.0
TLS2_k127_5455023_1 Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007081 601.0
TLS2_k127_5455023_2 Homospermidine synthase K00808 - 2.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 497.0
TLS2_k127_5455023_3 Subunit C of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05560 - - 0.000000000000000000000000000000000000000000000000115 182.0
TLS2_k127_5455023_4 Na+/H+ ion antiporter subunit K05562 - - 0.0000000000000000000000000000000000000002316 161.0
TLS2_k127_5455023_5 Monovalent cation proton antiporter subunit MnhG PhaG K05564 - - 0.000000000000000000000000000000000001571 141.0
TLS2_k127_5455023_6 SMART alpha amylase, catalytic sub domain K05343 - 3.2.1.1,5.4.99.16 0.00000000000000000000000000000000338 132.0
TLS2_k127_5455023_7 Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05563 - - 0.000000000000000000000000000002678 122.0
TLS2_k127_5460502_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008901 574.0
TLS2_k127_5460502_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007841 467.0
TLS2_k127_5460502_10 Biopolymer transport protein ExbD/TolR - - - 0.0000000000000000000000000000000000000000000000001027 181.0
TLS2_k127_5460502_11 - - - - 0.0000000000000000000000000000000000000001413 154.0
TLS2_k127_5460502_12 Biopolymer K03559 - - 0.00000000000000000000000000000000000002346 147.0
TLS2_k127_5460502_13 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 - - 0.0000000000000000000000000000006364 128.0
TLS2_k127_5460502_14 Belongs to the UPF0250 family K09158 - - 0.00000000000000000005042 98.0
TLS2_k127_5460502_15 Involved in formation and maintenance of cell shape K03570 - - 0.00002798 48.0
TLS2_k127_5460502_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 402.0
TLS2_k127_5460502_3 Belongs to the peptidase S11 family K07258 GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 392.0
TLS2_k127_5460502_4 Lytic murein transglycosylase B K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 295.0
TLS2_k127_5460502_5 bacteriocin transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 289.0
TLS2_k127_5460502_6 PFAM Aminotransferase, class IV K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001407 279.0
TLS2_k127_5460502_7 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000000002963 258.0
TLS2_k127_5460502_8 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000004086 243.0
TLS2_k127_5460502_9 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000003392 227.0
TLS2_k127_5477821_0 Belongs to the cysteine synthase cystathionine beta- synthase family - - - 1.658e-217 685.0
TLS2_k127_5477821_1 protein conserved in bacteria - - - 1.176e-209 672.0
TLS2_k127_5477821_2 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000003276 216.0
TLS2_k127_5492842_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 482.0
TLS2_k127_5492842_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 311.0
TLS2_k127_5492842_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 312.0
TLS2_k127_5497944_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1093.0
TLS2_k127_5497944_1 Sigma factor regulator FecR K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008361 294.0
TLS2_k127_5509916_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000002832 115.0
TLS2_k127_5509916_1 Histidine kinase - - - 0.00000000000000000007198 97.0
TLS2_k127_5509916_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000006716 54.0
TLS2_k127_5509916_3 Small-conductance mechanosensitive - - - 0.000002909 51.0
TLS2_k127_5529418_0 Protein of unknown function (DUF3570) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 382.0
TLS2_k127_5529418_1 ApbE family K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 307.0
TLS2_k127_5529418_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007898 279.0
TLS2_k127_5529418_3 Thioredoxin-like - - - 0.00000000000000000000000000000000000001051 148.0
TLS2_k127_5529418_4 DNA-templated transcription, initiation K03088,K03091 - - 0.00000000000000000000000000000002057 134.0
TLS2_k127_5529418_5 Domain of unknown function (DUF4266) - - - 0.0000000000000000002549 94.0
TLS2_k127_5529418_6 - - - - 0.0000003612 60.0
TLS2_k127_5529418_7 Domain of unknown function (DUF4880) K07165 - - 0.000003825 58.0
TLS2_k127_5535187_0 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 518.0
TLS2_k127_5535187_1 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 392.0
TLS2_k127_5535187_2 outer membrane autotransporter barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008904 276.0
TLS2_k127_5548334_0 DNA ligase K01971 - 6.5.1.1 0.0 1081.0
TLS2_k127_5548334_1 Malic enzyme K00029 - 1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009921 439.0
TLS2_k127_5548334_10 Diguanylate cyclase K03320 - - 0.00000000000000000000000000000000000001065 166.0
TLS2_k127_5548334_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 364.0
TLS2_k127_5548334_3 Acyl-CoA oxidase K00232 - 1.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 377.0
TLS2_k127_5548334_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 363.0
TLS2_k127_5548334_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008031 359.0
TLS2_k127_5548334_6 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 320.0
TLS2_k127_5548334_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 296.0
TLS2_k127_5548334_8 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002729 278.0
TLS2_k127_5548334_9 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000002704 233.0
TLS2_k127_555983_0 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006563 494.0
TLS2_k127_555983_1 sulfate ABC transporter K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 379.0
TLS2_k127_555983_2 transport system K02046,K15496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000911 368.0
TLS2_k127_555983_3 Two component transcriptional regulator, winged helix family - - - 0.000369 46.0
TLS2_k127_5567643_0 Sulfite reductase - - - 5.64e-214 673.0
TLS2_k127_5567643_1 ABC transporter transmembrane region K06147,K11085 - - 7.607e-212 676.0
TLS2_k127_5567643_2 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303,K02304 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 467.0
TLS2_k127_5567643_3 in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon K13634 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008141 393.0
TLS2_k127_5567643_4 Pyridoxal-phosphate dependent enzyme K01697,K01738 - 2.5.1.47,4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003396 276.0
TLS2_k127_5567643_5 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000226 268.0
TLS2_k127_5567643_6 conserved protein ucp030820 - - - 0.0000000000000000000000000001119 122.0
TLS2_k127_5595288_0 Belongs to the IlvD Edd family K13875 - 4.2.1.25 3.293e-297 916.0
TLS2_k127_5595288_1 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 387.0
TLS2_k127_5595288_2 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 370.0
TLS2_k127_5595288_3 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 379.0
TLS2_k127_5595288_4 Cell shape determining protein MreB Mrl - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 312.0
TLS2_k127_5595288_5 N-Acetylmuramoyl-L-alanine amidase K11066,K12287 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000001339 234.0
TLS2_k127_5595288_6 polysaccharide biosynthetic process - - - 0.0000000000000000000000003551 119.0
TLS2_k127_5595288_7 response regulator - - - 0.00000000006138 68.0
TLS2_k127_5604300_0 Phage plasmid primase P4 family - - - 0.0000000000000000000000000000000000001673 160.0
TLS2_k127_5604300_1 Peptidase family M20/M25/M40 K01438 - 3.5.1.16 0.000003436 55.0
TLS2_k127_562271_0 LeuA allosteric (dimerisation) domain K01649 - 2.3.3.13 2.075e-245 769.0
TLS2_k127_562271_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 377.0
TLS2_k127_562271_2 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000008862 235.0
TLS2_k127_562271_3 Inositol monophosphatase family K01082 - 3.1.3.7 0.00000001737 55.0
TLS2_k127_562271_4 Fatty acid hydroxylase - - - 0.00003119 51.0
TLS2_k127_5626735_0 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 455.0
TLS2_k127_5626735_1 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000007289 235.0
TLS2_k127_5643099_0 Glucose / Sorbosone dehydrogenase K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006834 479.0
TLS2_k127_5643099_1 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 439.0
TLS2_k127_5643099_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 415.0
TLS2_k127_5643099_3 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 421.0
TLS2_k127_5643099_4 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 346.0
TLS2_k127_5643099_5 O-methyltransferase K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001282 285.0
TLS2_k127_5643099_6 WHG domain - - - 0.0000000000000000000000000000000000000000000000007796 182.0
TLS2_k127_5643099_7 Type II secretion system protein B K02451 - - 0.000000000000002592 86.0
TLS2_k127_5643099_8 PFAM Outer membrane efflux protein - - - 0.000000001086 63.0
TLS2_k127_5643384_0 type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 522.0
TLS2_k127_5643384_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 506.0
TLS2_k127_5643384_10 - - - - 0.0000000000000000000007504 108.0
TLS2_k127_5643384_11 - - - - 0.0000000000000000008093 90.0
TLS2_k127_5643384_12 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000002928 86.0
TLS2_k127_5643384_13 - - - - 0.0000000003602 70.0
TLS2_k127_5643384_14 RHS Repeat - - - 0.00000002409 61.0
TLS2_k127_5643384_15 - - - - 0.0009779 51.0
TLS2_k127_5643384_2 serine-type endopeptidase activity K04772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 501.0
TLS2_k127_5643384_3 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 341.0
TLS2_k127_5643384_4 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000002066 250.0
TLS2_k127_5643384_5 PFAM TadE family protein - - - 0.0000000000000000000000000000000000000000000000000001073 201.0
TLS2_k127_5643384_6 type II secretion system protein K12511 - - 0.00000000000000000000000000000000000000000000000001539 191.0
TLS2_k127_5643384_7 Type II secretion system K12510 - - 0.000000000000000000000000000000000000000000000006585 183.0
TLS2_k127_5643384_8 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000000000000000000000001699 155.0
TLS2_k127_5643384_9 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000002922 124.0
TLS2_k127_5646242_0 FAD linked oxidase domain protein - - - 0.0 1997.0
TLS2_k127_5646242_1 Phospholipase D Active site motif K01115 - 3.1.4.4 3.172e-239 761.0
TLS2_k127_5646242_2 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 337.0
TLS2_k127_5646242_3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 334.0
TLS2_k127_5646242_4 Belongs to the UPF0502 family K09915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005396 252.0
TLS2_k127_5646242_5 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000004738 223.0
TLS2_k127_5657295_0 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 351.0
TLS2_k127_5657295_1 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001816 253.0
TLS2_k127_5657295_2 Bacterial regulatory protein, arsR family - - - 0.000000000000000000000000000000000000000000000000000000000000000009615 228.0
TLS2_k127_5667869_0 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 368.0
TLS2_k127_5667869_1 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000001138 222.0
TLS2_k127_5667869_2 MafB19-like deaminase K01487 - 3.5.4.3 0.00000000000000000000000000000000000000000000000000000004871 200.0
TLS2_k127_5667869_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000004296 176.0
TLS2_k127_5667869_4 Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins - - - 0.000000000000000000000000000001239 124.0
TLS2_k127_5674344_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007372 432.0
TLS2_k127_5674344_1 RES - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003125 280.0
TLS2_k127_5674344_2 Protein of unknown function (DUF2384) - - - 0.00000000000000000000000000000000000000000001214 165.0
TLS2_k127_5674344_3 Membrane - - - 0.0000000000000001162 90.0
TLS2_k127_5674344_4 Protein of unknown function (DUF559) - - - 0.000000008142 63.0
TLS2_k127_5686762_0 PFAM Transposase, IS801 IS1294 - - - 0.00000000000000000000000000000000000000000001404 173.0
TLS2_k127_5686762_1 Belongs to the 'phage' integrase family - - - 0.00000000000000009718 83.0
TLS2_k127_568754_0 protein conserved in bacteria - - - 1.195e-240 758.0
TLS2_k127_568887_0 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 471.0
TLS2_k127_568887_1 Hydrolase of alkaline phosphatase superfamily K07014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 451.0
TLS2_k127_568887_2 - - - - 0.0000000000000000000000000000002002 135.0
TLS2_k127_568887_3 Phospholipase/Carboxylesterase - - - 0.000000000000000003029 99.0
TLS2_k127_568887_4 OmpA family - - - 0.000000002865 70.0
TLS2_k127_568887_5 - - - - 0.0002477 48.0
TLS2_k127_569673_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 415.0
TLS2_k127_569673_1 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009453 311.0
TLS2_k127_569673_2 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000004908 245.0
TLS2_k127_569673_3 COG3307 Lipid A core - O-antigen ligase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000001779 239.0
TLS2_k127_569673_4 Glycosyltransferase family 87 - - - 0.0000000000000000000000000000000000000000000000001654 193.0
TLS2_k127_5708498_0 nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC K02567 - - 0.0 1370.0
TLS2_k127_5708498_1 Multicopper oxidase K00368 - 1.7.2.1 4.818e-243 758.0
TLS2_k127_5708498_10 protein involved in formation of periplasmic nitrate reductase K02570 - - 0.000000007829 64.0
TLS2_k127_5708498_2 NapC/NirT cytochrome c family, N-terminal region K02569,K03532 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 331.0
TLS2_k127_5708498_3 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002133 281.0
TLS2_k127_5708498_4 Invasion gene expression up-regulator, SirB - - - 0.0000000000000000000000000000000000000000001108 162.0
TLS2_k127_5708498_5 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB K02568 GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114 - 0.000000000000000000000000000000000000000007133 162.0
TLS2_k127_5708498_6 SCO1/SenC - - - 0.000000000000000000000000000000000003462 147.0
TLS2_k127_5708498_7 protein involved in response to NO K07234 - - 0.0000000000000431 72.0
TLS2_k127_5708498_8 Ferredoxin-type protein NapF K02572 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0050896 - 0.00000000000141 72.0
TLS2_k127_5708498_9 Nitrate reductase K02571 - - 0.0000000001027 63.0
TLS2_k127_5714235_0 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 5.414e-292 902.0
TLS2_k127_5714235_1 acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003538 279.0
TLS2_k127_5714235_2 Tannase and feruloyl esterase - - - 0.000000000000000000000000000000000000009489 150.0
TLS2_k127_571774_0 Reductase C-terminal K00529 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000168 228.0
TLS2_k127_571774_1 Domain of unknown function (DUF4142) K08995 - - 0.0000000000000000000000000000000000000000000000000000000000000000019 230.0
TLS2_k127_571774_2 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000001312 217.0
TLS2_k127_571774_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000001674 168.0
TLS2_k127_571774_4 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000000000000001255 121.0
TLS2_k127_571774_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000127 102.0
TLS2_k127_571774_6 Bacterial-like globin K06886 - - 0.0000008948 51.0
TLS2_k127_5719124_0 May be involved in recombination K03554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 344.0
TLS2_k127_5719124_1 membrane - - - 0.0000000000000000000000000000001702 132.0
TLS2_k127_5719124_2 - - - - 0.0002508 50.0
TLS2_k127_5724296_0 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 424.0
TLS2_k127_5724460_0 TIGRFAM ribonuclease, Rne Rng family K08301 - - 1.508e-198 638.0
TLS2_k127_5724460_1 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 519.0
TLS2_k127_5724460_10 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004329 311.0
TLS2_k127_5724460_11 DNA polymerase III, delta subunit K02340 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 298.0
TLS2_k127_5724460_12 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000004196 233.0
TLS2_k127_5724460_13 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000001189 214.0
TLS2_k127_5724460_14 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000002823 193.0
TLS2_k127_5724460_15 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 0.000000000000000000000000000000000000000001186 163.0
TLS2_k127_5724460_16 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000287 132.0
TLS2_k127_5724460_2 MatE K03327 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 494.0
TLS2_k127_5724460_3 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 503.0
TLS2_k127_5724460_4 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 469.0
TLS2_k127_5724460_5 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000692 466.0
TLS2_k127_5724460_6 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 419.0
TLS2_k127_5724460_7 Protein of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 425.0
TLS2_k127_5724460_8 PFAM regulatory protein LysR K11921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 377.0
TLS2_k127_5724460_9 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 351.0
TLS2_k127_5737009_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 606.0
TLS2_k127_5737009_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 493.0
TLS2_k127_5737375_0 Vitamin K epoxide reductase family - - - 1.166e-321 1009.0
TLS2_k127_5737375_1 mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 327.0
TLS2_k127_5737375_2 Cytochrome C oxidase subunit II, periplasmic domain K02275,K02826 - 1.10.3.12,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003203 286.0
TLS2_k127_5737375_3 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004156 276.0
TLS2_k127_5737375_4 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000000000000000000000000000000000002823 194.0
TLS2_k127_5737375_5 Uncharacterised protein family (UPF0093) - - - 0.0000000000000001803 85.0
TLS2_k127_5746039_0 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 293.0
TLS2_k127_5746039_1 Putative transposase of IS4/5 family (DUF4096) - - - 0.0000000000000000000000000000000000000000000005365 168.0
TLS2_k127_5746039_2 Transposase DDE domain - - - 0.000000000000000000000000000002516 125.0
TLS2_k127_5746039_3 - - - - 0.00000525 50.0
TLS2_k127_5747142_0 Circularly permuted ATP-grasp type 2 - - - 1.3e-239 749.0
TLS2_k127_5747142_1 PAS fold - - - 2.51e-218 694.0
TLS2_k127_5747142_2 A predicted alpha-helical domain with a conserved ER motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 388.0
TLS2_k127_5747142_3 PFAM 20S proteasome, A and B subunits K07395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 346.0
TLS2_k127_5747142_4 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003407 265.0
TLS2_k127_5747142_5 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007182 268.0
TLS2_k127_5747142_6 Peptidase_C39 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000726 252.0
TLS2_k127_5747142_7 cheY-homologous receiver domain - - - 0.000000000000000000000000000000004969 136.0
TLS2_k127_5759942_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 515.0
TLS2_k127_5759942_1 pectinesterase activity K10297,K15923,K18197 - 3.2.1.51,4.2.2.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008798 404.0
TLS2_k127_5759942_2 Protein of unknown function (DUF2785) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001502 243.0
TLS2_k127_5759942_3 - - - - 0.000000000000000000009441 101.0
TLS2_k127_5760711_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 6.974e-287 900.0
TLS2_k127_5760711_1 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007058 533.0
TLS2_k127_5760711_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 495.0
TLS2_k127_5760711_3 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 374.0
TLS2_k127_5760711_4 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000009137 270.0
TLS2_k127_5760711_5 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.00000000000000000000000000000000000000000000000000008067 194.0
TLS2_k127_5760711_6 PFAM VanZ - - - 0.0000000000000001814 85.0
TLS2_k127_5767241_0 Belongs to the TPP enzyme family K00156 - 1.2.5.1 3.882e-279 868.0
TLS2_k127_5767241_1 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 443.0
TLS2_k127_5767241_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 375.0
TLS2_k127_5767241_3 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000009848 197.0
TLS2_k127_5767241_4 glyoxalase III activity - - - 0.000000000000000004758 83.0
TLS2_k127_5767241_5 Ribosomal protein L7/L12 C-terminal domain - - - 0.0000105 53.0
TLS2_k127_5777650_0 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005692 565.0
TLS2_k127_5777650_1 - - - - 0.00000000008036 68.0
TLS2_k127_5777650_2 Cellulose biosynthesis protein BcsQ - - - 0.000001304 60.0
TLS2_k127_5782593_0 thiamine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 325.0
TLS2_k127_5782593_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 293.0
TLS2_k127_5782593_2 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002148 248.0
TLS2_k127_5782593_3 D,D-heptose 1,7-bisphosphate phosphatase - - - 0.0000000000000000000000000000000000000000000000000183 181.0
TLS2_k127_5799292_0 Methionine synthase K00548 - 2.1.1.13 0.0 1086.0
TLS2_k127_5799292_1 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008495 377.0
TLS2_k127_5799292_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000001593 190.0
TLS2_k127_5805800_0 Pfam:Y_phosphatase3C K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 297.0
TLS2_k127_5805800_1 Protein tyrosine serine phosphatase K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000007643 274.0
TLS2_k127_5805800_2 Domain of unknown function DUF11 - - - 0.0000000000000000000000000000000000000000000000004615 180.0
TLS2_k127_5805800_3 Outer membrane protein beta-barrel family - - - 0.00000000000000000000000000000000000000004974 153.0
TLS2_k127_5815432_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 403.0
TLS2_k127_5815432_2 Belongs to the SlyX family K03745 - - 0.000786 45.0
TLS2_k127_5820048_0 synthase - - - 2.647e-230 728.0
TLS2_k127_5820048_1 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000000000002736 159.0
TLS2_k127_5820048_2 - - - - 0.0000000000000000000000000000000000000000249 155.0
TLS2_k127_5820048_3 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000009155 157.0
TLS2_k127_5820048_4 diguanylate cyclase - - - 0.0000000000000000000000000833 121.0
TLS2_k127_5820048_5 histidine kinase A domain protein - - - 0.00000000000000000002229 104.0
TLS2_k127_5825606_0 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000001363 138.0
TLS2_k127_5825606_1 Tetratricopeptide repeat - - - 0.000000000000000000000007237 116.0
TLS2_k127_5827269_0 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 9.766e-216 694.0
TLS2_k127_5827269_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 570.0
TLS2_k127_5827269_2 found to be peripherally associated with the inner membrane in Escherichia coli K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 546.0
TLS2_k127_5827269_3 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 459.0
TLS2_k127_5827269_4 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000000000000000002874 206.0
TLS2_k127_5827269_5 Tetratricopeptide repeat - - - 0.000000000006323 73.0
TLS2_k127_5833696_0 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.00000000000000000000000000000000000000000000000000000000000000003717 239.0
TLS2_k127_5833696_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000005066 132.0
TLS2_k127_5833696_2 Plays a role in the flagellum-specific transport system K02419 - - 0.00000000004236 63.0
TLS2_k127_5837417_0 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009587 319.0
TLS2_k127_5837417_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001131 282.0
TLS2_k127_5837417_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000001041 229.0
TLS2_k127_5837417_3 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000169 168.0
TLS2_k127_5837417_4 Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000191 91.0
TLS2_k127_5867755_0 Cellulase N-terminal ig-like domain - - - 0.0 1193.0
TLS2_k127_5867755_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 519.0
TLS2_k127_5867755_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 444.0
TLS2_k127_5867755_3 Beta-xylanase K01181 - 3.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000397 359.0
TLS2_k127_5867755_4 membrane K15977 - - 0.0000000000003197 72.0
TLS2_k127_5874618_0 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 5.257e-207 653.0
TLS2_k127_5874618_1 Acetoacetyl-CoA synthase K01907 - 6.2.1.16 0.0000000000000000000000000000000000000000002856 162.0
TLS2_k127_5880324_0 transcriptional Regulator, LysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 312.0
TLS2_k127_5880324_1 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000004522 98.0
TLS2_k127_5895162_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 548.0
TLS2_k127_5895162_1 Methyl-accepting chemotaxis protein (MCP) signaling domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 389.0
TLS2_k127_5895162_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000001589 184.0
TLS2_k127_5895162_3 Bacterial signalling protein N terminal repeat - - - 0.000000000000000000000000000000000000000001015 166.0
TLS2_k127_5895162_4 Response regulator receiver K02658 - - 0.00000000000000000000000000000000455 132.0
TLS2_k127_5895162_5 CheW-like domain - - - 0.00000000000000000000002008 107.0
TLS2_k127_5905010_0 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007329 273.0
TLS2_k127_5905010_1 Lysine exporter protein (Lyse ygga) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002489 240.0
TLS2_k127_5905010_2 PFAM DGPFAETKE family protein - - - 0.0000000000000000000000000000000000000000000000001576 181.0
TLS2_k127_5910007_0 Two component transcriptional regulator, winged helix family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004708 269.0
TLS2_k127_5910007_1 Putative 2OG-Fe(II) oxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004887 260.0
TLS2_k127_5910007_2 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001718 228.0
TLS2_k127_5910007_3 DoxX - - - 0.000000000000000000000000000000000000000009111 160.0
TLS2_k127_5910007_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000001304 150.0
TLS2_k127_5910007_5 Domain of unknown function (DUF4168) - - - 0.000002079 57.0
TLS2_k127_5910007_6 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.00008702 45.0
TLS2_k127_5910007_7 Belongs to the UPF0270 family K09898 - - 0.0007745 42.0
TLS2_k127_5912053_0 peptidase K01354 - 3.4.21.83 2.581e-248 786.0
TLS2_k127_5912053_1 Protein involved in outer membrane biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 350.0
TLS2_k127_5912053_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 333.0
TLS2_k127_5912053_3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000007402 261.0
TLS2_k127_5912053_4 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000001498 150.0
TLS2_k127_5912053_5 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000001079 85.0
TLS2_k127_5912053_6 chaperone-mediated protein folding - - - 0.00003874 57.0
TLS2_k127_5913748_0 COG3666 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007017 464.0
TLS2_k127_5913748_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000004608 147.0
TLS2_k127_5916290_0 Glycosyl transferase family 21 - - - 1.481e-208 662.0
TLS2_k127_5916290_1 oxidase, subunit K00425 - 1.10.3.14 1.716e-195 619.0
TLS2_k127_5916290_2 oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 512.0
TLS2_k127_5927044_0 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 288.0
TLS2_k127_5927044_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000001116 213.0
TLS2_k127_5927044_2 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015232,GO:0015886,GO:0022857,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:1901678 3.6.3.41 0.00000000000000000000000000000000000000000000007679 180.0
TLS2_k127_5927044_3 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000002071 92.0
TLS2_k127_5927044_5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.0004845 45.0
TLS2_k127_5937130_0 Rieske [2Fe-2S] domain K09471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 560.0
TLS2_k127_5937130_1 DoxX-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008599 451.0
TLS2_k127_5937130_2 Predicted integral membrane protein (DUF2269) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001026 240.0
TLS2_k127_5937130_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000261 167.0
TLS2_k127_5937130_4 Response regulator receiver domain - - - 0.0000000000000000000000000000005247 128.0
TLS2_k127_5937130_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0004873 46.0
TLS2_k127_5953470_0 twitching motility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 428.0
TLS2_k127_5953470_1 Oxidoreductase FAD-binding domain K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 341.0
TLS2_k127_5953470_2 PFAM Type II secretion system protein E K02670 - - 0.000000000000000000000000000000000000000000000000000000000002303 211.0
TLS2_k127_5954389_0 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 564.0
TLS2_k127_5954389_1 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008893 280.0
TLS2_k127_5960203_0 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00124 - - 2.704e-246 770.0
TLS2_k127_5960203_1 Formate dehydrogenase alpha subunit K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 606.0
TLS2_k127_5960203_2 Zinc-binding dehydrogenase K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 441.0
TLS2_k127_5960203_3 Glutathione-dependent formaldehyde-activating enzyme K03396 - 4.4.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 302.0
TLS2_k127_5960203_4 Thioredoxin-like [2Fe-2S] ferredoxin K00127 - - 0.0000000000000000000000000000000000000000000000000008662 190.0
TLS2_k127_5964873_0 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 539.0
TLS2_k127_5964873_1 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069,K11073 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 419.0
TLS2_k127_5964873_2 Binding-protein-dependent transport system inner membrane component K11071,K11075 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 411.0
TLS2_k127_5964873_3 COG1177 ABC-type spermidine putrescine transport system, permease component II K11074 - - 0.000000000001865 70.0
TLS2_k127_5989198_0 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 442.0
TLS2_k127_5989198_1 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003871 261.0
TLS2_k127_5989198_2 - - - - 0.00000000000000000000000000000000000000000000000003831 196.0
TLS2_k127_5995083_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1454.0
TLS2_k127_5995083_1 TonB dependent receptor - - - 3.617e-264 838.0
TLS2_k127_5995083_10 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000002932 221.0
TLS2_k127_5995083_11 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000000000001521 214.0
TLS2_k127_5995083_12 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000000000000000000001332 207.0
TLS2_k127_5995083_13 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000002986 202.0
TLS2_k127_5995083_14 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.000000000000000000000000000000000000000000000000000004425 193.0
TLS2_k127_5995083_15 2-oxopent-4-enoate hydratase activity K02554 - 4.2.1.80 0.0000000000000000000000000000000000000000000000000001579 195.0
TLS2_k127_5995083_16 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000001852 179.0
TLS2_k127_5995083_17 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000007121 175.0
TLS2_k127_5995083_18 Ribosomal protein L17 K02879 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000002067 171.0
TLS2_k127_5995083_19 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000001896 153.0
TLS2_k127_5995083_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.554e-196 620.0
TLS2_k127_5995083_20 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000002242 113.0
TLS2_k127_5995083_21 -acetyltransferase - - - 0.00000000000000000000000001349 115.0
TLS2_k127_5995083_22 TIGRFAM ribosomal protein L30 K02907 - - 0.0000000000000001509 80.0
TLS2_k127_5995083_23 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000004487 65.0
TLS2_k127_5995083_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00322 - 1.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 570.0
TLS2_k127_5995083_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 484.0
TLS2_k127_5995083_5 Splits dipeptides with a prolyl residue in the C- terminal position K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 465.0
TLS2_k127_5995083_6 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 342.0
TLS2_k127_5995083_7 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 310.0
TLS2_k127_5995083_8 Diphthamide synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008163 263.0
TLS2_k127_5995083_9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000006712 232.0
TLS2_k127_5998221_0 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 476.0
TLS2_k127_5998221_1 7TMR-DISM extracellular 2 - - - 0.000000000000000000000000000000000000003716 149.0
TLS2_k127_5998221_2 PFAM Glutathione-dependent formaldehyde-activating, GFA - - - 0.00000000000000000000000000000000000001146 149.0
TLS2_k127_5998221_3 YjbR - - - 0.000000000000000000000000000008561 129.0
TLS2_k127_5998221_4 YjbR - - - 0.00000000000000027 89.0
TLS2_k127_6014189_0 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006954 381.0
TLS2_k127_6014189_1 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000969 263.0
TLS2_k127_6014189_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000006686 152.0
TLS2_k127_6014189_3 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000002171 87.0
TLS2_k127_6022534_0 TonB-dependent Receptor Plug Domain K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 396.0
TLS2_k127_6022534_1 PFAM Glutathione S-transferase, C-terminal domain K07393 - 1.8.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 293.0
TLS2_k127_6033486_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 565.0
TLS2_k127_6033486_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 456.0
TLS2_k127_6033486_2 Belongs to the CinA family K03743 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159 3.5.1.42 0.00000000000000000000000000000000000000000006548 166.0
TLS2_k127_6033486_3 Modulates RecA activity K03565 - - 0.00000000000000000000000000000001074 133.0
TLS2_k127_6033486_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000004341 113.0
TLS2_k127_604989_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 4.539e-267 845.0
TLS2_k127_604989_1 Glycosyl hydrolases family 39 - - - 5.525e-239 751.0
TLS2_k127_604989_2 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 547.0
TLS2_k127_604989_3 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001159 259.0
TLS2_k127_604989_4 Thioesterase - - - 0.000000000000000000000000000000000000000000000000000000007387 209.0
TLS2_k127_604989_5 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000001846 149.0
TLS2_k127_6051781_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000004338 192.0
TLS2_k127_6051781_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000004791 189.0
TLS2_k127_6051781_2 Peptidase A24A, prepilin type IV K02278 - 3.4.23.43 0.000000000000000000000000000000000002928 145.0
TLS2_k127_6051781_3 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000005569 134.0
TLS2_k127_6051781_4 response regulator - - - 0.0000000000000000000003424 104.0
TLS2_k127_6051781_5 Flp Fap pilin component K02651 - - 0.000000001235 61.0
TLS2_k127_6051781_6 Flp Fap pilin component K02651 - - 0.0000007937 54.0
TLS2_k127_6060319_0 Protein of unknown function (DUF1587) - - - 8.147e-235 753.0
TLS2_k127_6060319_1 Protein of unknown function (DUF1552) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 523.0
TLS2_k127_6060319_2 COG0668 Small-conductance mechanosensitive channel K16052 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 403.0
TLS2_k127_6060319_3 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 392.0
TLS2_k127_6060319_4 Alpha Beta K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 319.0
TLS2_k127_6060319_5 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000000004321 226.0
TLS2_k127_6060319_6 Cytochrome C' - - - 0.0000000000000000000002062 103.0
TLS2_k127_6060319_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000002368 72.0
TLS2_k127_6060319_8 Fe2 -dicitrate sensor, membrane component K07165 - - 0.0000009124 61.0
TLS2_k127_6061285_0 Belongs to the UPF0276 family K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 367.0
TLS2_k127_6061285_1 fumarylacetoacetate (FAA) hydrolase K16165 - 3.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 306.0
TLS2_k127_6061285_2 Putative DNA-binding domain - - - 0.000000000000000000000000000000000000000000000001837 183.0
TLS2_k127_6061285_3 BON domain K04065 - - 0.0000000000000000002554 91.0
TLS2_k127_6061285_4 - - - - 0.000000000000000006264 91.0
TLS2_k127_6084982_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 490.0
TLS2_k127_6084982_1 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 428.0
TLS2_k127_6084982_2 SMART Elongator protein 3 MiaB NifB K22226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 306.0
TLS2_k127_6084982_3 Aldo/keto reductase family - - - 0.000000000001284 71.0
TLS2_k127_6128702_0 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004378 244.0
TLS2_k127_6128702_1 DNA primase activity - - - 0.000000000000000000000000000005538 124.0
TLS2_k127_6128702_2 N-terminal 7TM region of histidine kinase - - - 0.00000000000000000000000000001971 130.0
TLS2_k127_6128702_3 Response regulator receiver domain - - - 0.000000000000000000000002771 110.0
TLS2_k127_6140156_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 398.0
TLS2_k127_6140156_1 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 347.0
TLS2_k127_6140156_2 Sigma-70, region 4 - - - 0.000000000000000000000000000000000000000000000000000000001215 204.0
TLS2_k127_6140156_3 AntiSigma factor - - - 0.000000000000000000000000000000000000001931 156.0
TLS2_k127_6140156_4 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000003368 89.0
TLS2_k127_6149477_0 His Kinase A (phosphoacceptor) domain K20971 - - 4.365e-225 708.0
TLS2_k127_6151805_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 3.426e-270 841.0
TLS2_k127_6151805_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 556.0
TLS2_k127_6151805_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 549.0
TLS2_k127_6151805_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 445.0
TLS2_k127_6151805_4 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 441.0
TLS2_k127_6151805_5 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000002523 259.0
TLS2_k127_6151805_6 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.00000000000000000000000000000000000000000000000000000000000000000001364 248.0
TLS2_k127_6151805_7 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000002667 157.0
TLS2_k127_6151805_8 TIGRFAM Competence protein ComEA, helix-hairpin-helix K02237 - - 0.000000000000004287 83.0
TLS2_k127_6153830_0 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 1.049e-242 780.0
TLS2_k127_6153830_1 SH3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001232 261.0
TLS2_k127_6153830_2 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000000000005613 235.0
TLS2_k127_6153830_3 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000001974 198.0
TLS2_k127_6155535_0 Peptidase family M13 K07386 - - 1.303e-223 713.0
TLS2_k127_6155535_1 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003454 266.0
TLS2_k127_6155535_2 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007655 251.0
TLS2_k127_6155535_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000002734 207.0
TLS2_k127_6155535_4 membrane - - - 0.0000000000000000000000000000000000000000001214 167.0
TLS2_k127_6155535_5 Protein of unknown function (DUF1232) - - - 0.0000000000000135 79.0
TLS2_k127_6169144_0 DEAD DEAH box helicase K03724 - - 0.0 1825.0
TLS2_k127_6169144_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1021.0
TLS2_k127_6169144_2 PFAM PrkA AAA K07180 - - 5.565e-304 944.0
TLS2_k127_6169144_3 SpoVR like protein K06415 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 566.0
TLS2_k127_6169144_4 Belongs to the UPF0229 family K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 393.0
TLS2_k127_6169144_5 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007988 259.0
TLS2_k127_6169144_6 NmrA-like family - - - 0.00000000000000000000000000000000000000000001404 173.0
TLS2_k127_6169144_7 Hsp20/alpha crystallin family - - - 0.00000000000000000000000000000000224 134.0
TLS2_k127_6169144_8 Outer membrane usher protein K07347 - - 0.000000000000000000000000000005869 135.0
TLS2_k127_6169144_9 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000001117 79.0
TLS2_k127_6180836_0 PFAM ABC transporter K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 498.0
TLS2_k127_6180836_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 471.0
TLS2_k127_6180836_2 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 346.0
TLS2_k127_6180836_3 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000002997 217.0
TLS2_k127_6181320_0 Signal transducing histidine kinase, homodimeric K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 367.0
TLS2_k127_6181320_1 Histidine phosphotransferase C-terminal domain K13588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004226 244.0
TLS2_k127_6192979_0 Peptidase M16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 528.0
TLS2_k127_6192979_1 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 496.0
TLS2_k127_6192979_2 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 430.0
TLS2_k127_6192979_3 Domain of unknown function (DUF4010) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 361.0
TLS2_k127_6192979_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007941 301.0
TLS2_k127_6192979_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000115 194.0
TLS2_k127_6192979_6 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000001125 177.0
TLS2_k127_6192979_7 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000007482 63.0
TLS2_k127_6205056_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007272 521.0
TLS2_k127_6205056_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 389.0
TLS2_k127_6205056_2 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 367.0
TLS2_k127_6205056_3 PFAM Aminoglycoside phosphotransferase K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 348.0
TLS2_k127_6205056_4 PFAM Nucleotidyl transferase K00992 - 2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005855 271.0
TLS2_k127_6205056_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000008307 258.0
TLS2_k127_6205056_6 - - - - 0.0000000000000000000000000000000000001216 149.0
TLS2_k127_6205056_7 Universal stress protein K06149 - - 0.00000000000000000000000000001646 126.0
TLS2_k127_6206152_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000003703 174.0
TLS2_k127_622731_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 493.0
TLS2_k127_622731_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008077 445.0
TLS2_k127_622731_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 344.0
TLS2_k127_622731_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 310.0
TLS2_k127_6240446_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 412.0
TLS2_k127_6240446_1 histidine triad (HIT) protein - - - 0.0000000000000000000000000000000000000000000004953 169.0
TLS2_k127_6240446_2 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000001791 50.0
TLS2_k127_6269536_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1102.0
TLS2_k127_6269536_1 Glycosyl transferase family 21 K03669 GO:0005575,GO:0016020 - 2.534e-205 672.0
TLS2_k127_6269536_2 Alpha amylase, catalytic domain K01236 - 3.2.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 586.0
TLS2_k127_6269536_3 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 442.0
TLS2_k127_6269536_4 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000001163 176.0
TLS2_k127_6290897_0 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 1.378e-237 752.0
TLS2_k127_6290897_1 Gluconolactonase K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009818 487.0
TLS2_k127_6290897_2 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 432.0
TLS2_k127_6290897_3 Belongs to the UPF0178 family K09768 - - 0.0000000000000000000000000000000000000000000000000000001014 201.0
TLS2_k127_6290897_4 Domain of unknown function (DUF4112) - - - 0.0000000000000000000000000000000000005549 145.0
TLS2_k127_6304988_0 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 2.454e-223 702.0
TLS2_k127_6304988_1 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 510.0
TLS2_k127_6304988_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001439 275.0
TLS2_k127_6304988_3 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.000000000000000000000000000000000008802 143.0
TLS2_k127_6304988_4 Response regulator receiver domain - - - 0.000000000000000000000000009699 113.0
TLS2_k127_6304988_5 OsmC-like protein K07397 - - 0.00000000000000000000000009201 109.0
TLS2_k127_6304988_6 cheY-homologous receiver domain - - - 0.0000000000001646 78.0
TLS2_k127_6304988_7 Psort location Cytoplasmic, score 8.96 K07397 - - 0.0000000008801 60.0
TLS2_k127_6304988_8 DNA-templated transcription, initiation - - - 0.0001 54.0
TLS2_k127_6305525_0 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 454.0
TLS2_k127_6305525_1 Transcriptional regulator K11921,K19338 - - 0.00000000000000000000000000000000000000000000009788 182.0
TLS2_k127_6308797_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 389.0
TLS2_k127_6308797_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 313.0
TLS2_k127_6308797_2 RNA cap guanine-N2 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000001762 224.0
TLS2_k127_6308797_3 - - - - 0.00000000000000000000000000000000000000001699 167.0
TLS2_k127_6308797_4 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000002364 133.0
TLS2_k127_6308797_5 - - - - 0.00000000000000000000000002812 111.0
TLS2_k127_6308797_6 - - - - 0.00000002209 60.0
TLS2_k127_6317217_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008413 491.0
TLS2_k127_6317217_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 374.0
TLS2_k127_6317217_2 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000002685 234.0
TLS2_k127_6317217_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000009026 49.0
TLS2_k127_6317690_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 389.0
TLS2_k127_6317690_1 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 323.0
TLS2_k127_6329451_0 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 424.0
TLS2_k127_6329451_1 HlyD family secretion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 392.0
TLS2_k127_6329451_2 Methyl-transferase K06983 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 374.0
TLS2_k127_6329451_3 Trehalose utilisation K09992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 362.0
TLS2_k127_6329451_4 transmembrane transporter activity K18138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 351.0
TLS2_k127_6329451_5 PFAM NnrU protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002399 240.0
TLS2_k127_6337195_0 ABC transporter K15578 - - 9.869e-250 784.0
TLS2_k127_6337195_1 NMT1-like family K15576 - - 1.174e-232 730.0
TLS2_k127_6337195_10 Ca2 -binding protein (EF-Hand superfamily - - - 0.0000001336 57.0
TLS2_k127_6337195_2 Binding-protein-dependent transport system inner membrane component K15577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 451.0
TLS2_k127_6337195_3 ABC-type nitrate sulfonate bicarbonate transport K15576,K22067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006082 415.0
TLS2_k127_6337195_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 401.0
TLS2_k127_6337195_5 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009021 372.0
TLS2_k127_6337195_6 response regulator receiver K07183 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001179 253.0
TLS2_k127_6337195_7 - - - - 0.000000000000000000002146 97.0
TLS2_k127_6337195_8 - - - - 0.00000000005594 63.0
TLS2_k127_6337195_9 Belongs to the ompA family K03286 - - 0.000000001365 68.0
TLS2_k127_6371314_0 amidohydrolase - - - 8.11e-196 621.0
TLS2_k127_6371314_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 486.0
TLS2_k127_6391462_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 464.0
TLS2_k127_6391462_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 308.0
TLS2_k127_6391462_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000001467 262.0
TLS2_k127_6396574_0 Encapsulating protein for peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 328.0
TLS2_k127_6396574_1 Evidence 4 Homologs of previously reported genes of K09700 - - 0.000000000000000000000000000000000000006345 147.0
TLS2_k127_6396574_2 Transcriptional regulator K03566 - - 0.0000000000000000000000000005109 121.0
TLS2_k127_639924_0 General secretion pathway protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 438.0
TLS2_k127_639924_1 Cytosol aminopeptidase family, catalytic domain K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 365.0
TLS2_k127_639924_2 EamA-like transporter family K15268 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002439 263.0
TLS2_k127_6400205_0 Subtilase family K14645 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 424.0
TLS2_k127_6400205_1 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 374.0
TLS2_k127_6403612_0 response regulator receiver K02487,K06596 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 451.0
TLS2_k127_6403612_1 chemotaxis protein K02660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 420.0
TLS2_k127_6403612_2 chemotaxis signal transduction protein K02659 - - 0.000000000000000000000000005719 114.0
TLS2_k127_6417406_0 Sodium/hydrogen exchanger family - - - 1.093e-204 643.0
TLS2_k127_6417406_1 PFAM Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006866 256.0
TLS2_k127_6417406_2 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000001695 237.0
TLS2_k127_6417406_3 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004029 234.0
TLS2_k127_6417406_4 Cysteine methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000007272 229.0
TLS2_k127_6417406_5 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000006625 223.0
TLS2_k127_6417406_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00004862 52.0
TLS2_k127_6438818_0 Aminotransferase class I and II K00652,K01906 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.2.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 342.0
TLS2_k127_6438818_1 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006127 267.0
TLS2_k127_6438818_2 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000004839 200.0
TLS2_k127_6438818_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.000001464 51.0
TLS2_k127_6438818_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15785 - 2.6.1.76 0.00001145 50.0
TLS2_k127_6472918_0 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 1.111e-246 782.0
TLS2_k127_6472918_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822,K00833 - 2.6.1.18,2.6.1.62 9.327e-209 657.0
TLS2_k127_6472918_2 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 436.0
TLS2_k127_6472918_3 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001 242.0
TLS2_k127_6481561_0 L-glyceraldehyde 3-phosphate reductase K19265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002426 241.0
TLS2_k127_6481561_1 Belongs to the pseudouridine synthase RsuA family K06181 - 5.4.99.20 0.000000000000000000000000000000000000000000000002898 176.0
TLS2_k127_6481561_2 Bacterial PH domain - - - 0.000000000000000000000000002134 118.0
TLS2_k127_6481561_3 - - - - 0.00000000000007598 78.0
TLS2_k127_6487635_0 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 400.0
TLS2_k127_6487635_1 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 304.0
TLS2_k127_6487635_2 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity - - - 0.000000000000000000000000000000000000000000000000000000000000009828 222.0
TLS2_k127_649453_0 Trehalose utilisation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 390.0
TLS2_k127_649453_1 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 357.0
TLS2_k127_6496702_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000005669 154.0
TLS2_k127_6496702_1 - - - - 0.000000000000000000008441 101.0
TLS2_k127_6496702_2 - - - - 0.00000000000004292 75.0
TLS2_k127_6496702_3 Protein of unknown function (DUF3379) - - - 0.000000000003163 75.0
TLS2_k127_6508322_0 Amidohydrolase family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009134 475.0
TLS2_k127_6508322_1 deiminase K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 405.0
TLS2_k127_6508322_2 OmpA-like transmembrane domain - - - 0.0000000000604 73.0
TLS2_k127_6519835_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.0 1125.0
TLS2_k127_6519835_1 multicopper - - - 3.499e-243 765.0
TLS2_k127_6519835_2 Copper resistance K07233 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000339 256.0
TLS2_k127_6519835_3 conserved secreted or membrane protein precursor - - - 0.000000000000000000000000000000000000000000000000000000001489 209.0
TLS2_k127_6519835_4 helix_turn_helix, mercury resistance K19591 - - 0.00000000000000000000000000000000148 131.0
TLS2_k127_6519835_5 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000002041 125.0
TLS2_k127_6535765_0 siderophore transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008402 480.0
TLS2_k127_6535765_1 Belongs to the aldehyde dehydrogenase family K00141 - 1.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 372.0
TLS2_k127_6557981_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1176.0
TLS2_k127_6557981_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007007 532.0
TLS2_k127_6557981_2 Belongs to the phospholipase D family. Cardiolipin synthase subfamily K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 316.0
TLS2_k127_6557981_3 NADP oxidoreductase, coenzyme f420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008264 306.0
TLS2_k127_6557981_4 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 306.0
TLS2_k127_6557981_5 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002118 268.0
TLS2_k127_6557981_6 PFAM phosphoesterase PA-phosphatase related K19302 - 3.6.1.27 0.000000000000000000000000000000000000000000000002755 179.0
TLS2_k127_6557981_7 - - - - 0.0000003738 56.0
TLS2_k127_6559796_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001181 282.0
TLS2_k127_6559796_1 Tyrosine phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000001104 158.0
TLS2_k127_6559796_2 - - - - 0.0000000000000000003199 90.0
TLS2_k127_6589733_0 amino acid K03294 - - 1.451e-258 804.0
TLS2_k127_6589733_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 572.0
TLS2_k127_6589733_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004145 293.0
TLS2_k127_6589733_11 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000000000000000000000000000002598 250.0
TLS2_k127_6589733_12 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000006661 233.0
TLS2_k127_6589733_13 TIGRFAM type IV pilus biogenesis stability protein PilW K02656 - - 0.00000000000000000000000000000000000000000000000008356 187.0
TLS2_k127_6589733_14 Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system K13628 - - 0.0000000000000000000000000000000000000000001511 161.0
TLS2_k127_6589733_15 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000000000000001542 152.0
TLS2_k127_6589733_16 Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis K15539 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.000000000000000000000003254 114.0
TLS2_k127_6589733_17 NifU-like N terminal domain - - - 0.0000000000003409 76.0
TLS2_k127_6589733_2 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 518.0
TLS2_k127_6589733_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 465.0
TLS2_k127_6589733_4 Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 434.0
TLS2_k127_6589733_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 432.0
TLS2_k127_6589733_6 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 328.0
TLS2_k127_6589733_7 PFAM Integral membrane protein TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 327.0
TLS2_k127_6589733_8 Integral membrane protein TerC family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 320.0
TLS2_k127_6589733_9 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 325.0
TLS2_k127_6597809_0 Efflux pump membrane transporter K03296,K18138 - - 0.0 1509.0
TLS2_k127_6597809_1 Response regulator receiver - - - 3.137e-220 709.0
TLS2_k127_6597809_10 YCII-related domain - - - 0.000000000000000000000000000001239 124.0
TLS2_k127_6597809_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 2.766e-194 617.0
TLS2_k127_6597809_3 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 520.0
TLS2_k127_6597809_4 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 490.0
TLS2_k127_6597809_5 Outer membrane efflux protein K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006775 454.0
TLS2_k127_6597809_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 404.0
TLS2_k127_6597809_7 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006332 293.0
TLS2_k127_6597809_8 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000000000000000000000005951 156.0
TLS2_k127_6597809_9 PFAM YCII-related - - - 0.00000000000000000000000000000000001093 139.0
TLS2_k127_6634970_0 transporter - - - 3.923e-281 878.0
TLS2_k127_6634970_1 PFAM peptidase M2, peptidyl-dipeptidase A K01283 - 3.4.15.1 4.83e-234 738.0
TLS2_k127_6634970_2 POT family K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 496.0
TLS2_k127_6634970_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 299.0
TLS2_k127_6634970_4 diguanylate cyclase - - - 0.000000000000000000000000009834 119.0
TLS2_k127_6634970_5 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000000244 107.0
TLS2_k127_6634970_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000001548 70.0
TLS2_k127_6634970_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000003819 71.0
TLS2_k127_6639802_0 Transporter K03305 - - 1.524e-246 770.0
TLS2_k127_6639802_1 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 372.0
TLS2_k127_6639802_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00836 GO:0003674,GO:0003824,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019491,GO:0019752,GO:0032787,GO:0042399,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 365.0
TLS2_k127_6639802_4 Belongs to the ArsC family K00537 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 0.00000000000000000000000000000000000000000002248 163.0
TLS2_k127_6639802_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000007724 156.0
TLS2_k127_664095_0 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009466 298.0
TLS2_k127_664095_1 Histidine kinase K02484,K07640,K07642 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000009182 276.0
TLS2_k127_664095_2 transcriptional regulator K07662 - - 0.000000000000000000000000000000000000000000000000000000000000000201 228.0
TLS2_k127_664095_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000001101 150.0
TLS2_k127_664095_4 - - - - 0.000000005418 61.0
TLS2_k127_6646201_0 Glycosyl hydrolase, family 20, catalytic domain - - - 0.0 1131.0
TLS2_k127_6646201_1 Glycosyl hydrolase family 10 K01181 - 3.2.1.8 1.378e-201 651.0
TLS2_k127_6654627_0 PD-(D/E)XK nuclease superfamily - - - 3.287e-254 823.0
TLS2_k127_6654627_1 aminotransferase K14260 - 2.6.1.2,2.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 463.0
TLS2_k127_6654627_10 Type II secretion system (T2SS), protein M K02462 - - 0.00001511 54.0
TLS2_k127_6654627_2 electron transfer flavoprotein beta subunit K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 367.0
TLS2_k127_6654627_3 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 394.0
TLS2_k127_6654627_4 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 293.0
TLS2_k127_6654627_5 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000000005259 189.0
TLS2_k127_6654627_6 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.00000000000000000000000000000000000000227 162.0
TLS2_k127_6654627_7 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000005996 139.0
TLS2_k127_6654627_8 General secretion pathway protein J K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.0000000098 58.0
TLS2_k127_6654627_9 Type II secretion system (T2SS), protein N K02463 - - 0.000001154 59.0
TLS2_k127_6662148_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001174 295.0
TLS2_k127_6694146_0 Dehydrogenase E1 component K00164 GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 0.0 1105.0
TLS2_k127_6694146_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.497e-210 677.0
TLS2_k127_6694146_10 dTDP biosynthetic process K00560,K00943 - 2.1.1.45,2.7.4.9 0.0000000000000000000000000000000000000000000000000007502 206.0
TLS2_k127_6694146_11 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000000000000000000000002661 174.0
TLS2_k127_6694146_12 Biopolymer transport protein K03560 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000008456 151.0
TLS2_k127_6694146_13 Tol-Pal system-associated acyl-CoA thioesterase K07107 - - 0.000000000000000000000000000000000004556 142.0
TLS2_k127_6694146_14 Hexapeptide repeat of succinyl-transferase - - - 0.000000000000001217 91.0
TLS2_k127_6694146_2 E3 component of 2-oxoglutarate dehydrogenase complex K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 570.0
TLS2_k127_6694146_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007422 516.0
TLS2_k127_6694146_4 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 497.0
TLS2_k127_6694146_5 TIGRFAM Undecaprenyl-phosphate glucose phosphotransferase K03606 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 457.0
TLS2_k127_6694146_6 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 365.0
TLS2_k127_6694146_7 helix_turn_helix isocitrate lyase regulation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007339 326.0
TLS2_k127_6694146_8 PFAM MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004261 256.0
TLS2_k127_6694146_9 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000147 219.0
TLS2_k127_6695346_0 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 338.0
TLS2_k127_6695346_1 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 296.0
TLS2_k127_6695346_2 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000004562 221.0
TLS2_k127_6695346_3 COG1943 Transposase and inactivated derivatives - - - 0.0000000000002695 73.0
TLS2_k127_6695685_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1090.0
TLS2_k127_6695685_1 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 410.0
TLS2_k127_6695685_2 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 291.0
TLS2_k127_6695685_3 PFAM cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000004616 216.0
TLS2_k127_6695685_4 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000001967 207.0
TLS2_k127_6695685_5 Thiol disulfide interchange protein K03673 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000002613 170.0
TLS2_k127_6695685_6 interspecies interaction between organisms - - - 0.00000000000000000000000009372 115.0
TLS2_k127_6695685_7 OmpA-like transmembrane domain - - - 0.0000000000000000004253 96.0
TLS2_k127_6696652_0 TIGRFAM diguanylate cyclase (GGDEF) domain K21023 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 621.0
TLS2_k127_6696652_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 481.0
TLS2_k127_6696652_10 - - - - 0.0000000000001372 77.0
TLS2_k127_6696652_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 401.0
TLS2_k127_6696652_3 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000003856 258.0
TLS2_k127_6696652_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000001784 258.0
TLS2_k127_6696652_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000005018 207.0
TLS2_k127_6696652_6 domain protein K17624 - 3.2.1.97 0.00000000000000000000000000000000000000000000000005373 204.0
TLS2_k127_6696652_7 TIGRFAM outer membrane autotransporter barrel - - - 0.00000000000000000000000000000000000000001117 177.0
TLS2_k127_6696652_8 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.000000000000000000000000000000000000002033 157.0
TLS2_k127_6696652_9 belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000003144 132.0
TLS2_k127_6704282_0 PFAM heat shock protein DnaJ domain protein K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 365.0
TLS2_k127_6704282_1 Histidine kinase K02482,K14986 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 308.0
TLS2_k127_6704282_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009878 277.0
TLS2_k127_6704282_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000004339 92.0
TLS2_k127_6727852_0 Glycosyl hydrolase family 9 - - - 2.646e-205 649.0
TLS2_k127_6727852_2 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000000008817 89.0
TLS2_k127_6727852_3 - - - - 0.00000005093 59.0
TLS2_k127_6728368_0 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000001848 192.0
TLS2_k127_6731942_0 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 649.0
TLS2_k127_6732856_0 peptidase M20 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007098 454.0
TLS2_k127_6732856_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 391.0
TLS2_k127_6732856_2 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 388.0
TLS2_k127_6732856_3 Inner membrane protein involved in colicin E2 resistance K06143 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 342.0
TLS2_k127_6732856_4 Preprotein translocase subunit TatD K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 320.0
TLS2_k127_6732856_5 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000000000000000000006948 209.0
TLS2_k127_6732856_6 WLM domain K07043 - - 0.0000000000000000000000000000000000000000000000006857 183.0
TLS2_k127_6732856_7 peptidyl-tyrosine sulfation - - - 0.0003577 53.0
TLS2_k127_6751532_0 Gluconolactonase K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 429.0
TLS2_k127_6751532_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 361.0
TLS2_k127_6751532_2 Phosphoenolpyruvate phosphomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008109 261.0
TLS2_k127_6751532_3 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000004371 226.0
TLS2_k127_6757556_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 388.0
TLS2_k127_6757556_1 alpha/beta hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006234 274.0
TLS2_k127_6757556_2 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000003892 202.0
TLS2_k127_6757556_3 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000006023 197.0
TLS2_k127_6757556_4 cellulase activity K01197,K01218,K12373 - 3.2.1.35,3.2.1.52,3.2.1.78 0.0000000000000001066 92.0
TLS2_k127_6780543_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.642e-205 649.0
TLS2_k127_6780543_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.827e-198 632.0
TLS2_k127_6780543_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 443.0
TLS2_k127_6780543_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 437.0
TLS2_k127_6780543_4 Cytosol aminopeptidase family, catalytic domain K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001549 258.0
TLS2_k127_6780543_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000001767 100.0
TLS2_k127_6782305_0 Esterase PHB depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 289.0
TLS2_k127_6782305_1 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000002218 183.0
TLS2_k127_6782305_2 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000007609 63.0
TLS2_k127_6789619_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 2.818e-276 864.0
TLS2_k127_6789619_1 Peptidase family M28 - - - 1.625e-198 636.0
TLS2_k127_6793219_0 Trehalose utilisation - - - 0.0 1047.0
TLS2_k127_6793219_1 Xylose isomerase K01816 - 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000004843 226.0
TLS2_k127_6808524_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 3.907e-230 726.0
TLS2_k127_6808524_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 410.0
TLS2_k127_6810131_0 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 334.0
TLS2_k127_6810131_1 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000006695 265.0
TLS2_k127_6810131_2 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.0000000000000000000000000006633 116.0
TLS2_k127_6810131_3 - - - - 0.0000000000001388 76.0
TLS2_k127_6810131_4 - - - - 0.0000008455 51.0
TLS2_k127_6822619_0 UvrD/REP helicase N-terminal domain - - - 9.545e-291 932.0
TLS2_k127_6822619_1 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 292.0
TLS2_k127_6841556_0 COG2031 Short chain fatty acids transporter K02106 - - 3.302e-210 662.0
TLS2_k127_6841556_1 CBS domain - - - 0.0000000000000000000000000000000000000000000000000002935 188.0
TLS2_k127_6841556_2 response regulator K02485 - - 0.000000000000007401 79.0
TLS2_k127_6841556_3 Tyrosine phosphatase family K01104 - 3.1.3.48 0.0000005898 53.0
TLS2_k127_6844590_0 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 314.0
TLS2_k127_6844590_1 (Lipo)protein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000004774 223.0
TLS2_k127_6846349_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000541 473.0
TLS2_k127_6846349_1 ATP-binding region ATPase domain protein - - - 0.0000000001489 73.0
TLS2_k127_6848689_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 415.0
TLS2_k127_6848689_1 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 387.0
TLS2_k127_6848689_2 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 374.0
TLS2_k127_6848689_3 of the major facilitator superfamily K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007383 281.0
TLS2_k127_6849534_0 Secretin N-terminal domain K12282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 428.0
TLS2_k127_6849534_1 Pilus assembly protein K12279 - - 0.0000000000000000000000000000000000000000002297 172.0
TLS2_k127_6849534_2 Type II secretion system (T2SS), protein M K12280 - - 0.00000000000000000000003277 109.0
TLS2_k127_6849534_3 PFAM Fimbrial assembly family protein - - - 0.0000000000000000003501 96.0
TLS2_k127_6849534_4 - K12281 - - 0.0000000008182 64.0
TLS2_k127_6865344_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008094 406.0
TLS2_k127_6865344_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 387.0
TLS2_k127_6865344_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 365.0
TLS2_k127_6865344_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 357.0
TLS2_k127_6865344_4 PhnA Zinc-Ribbon K06193 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000001618 183.0
TLS2_k127_6865344_5 MAPEG family - - - 0.00000000000000000000000000000000000000000000000009803 183.0
TLS2_k127_6880559_0 AraC family K13652 - - 0.00000000000000000000000000000000000000000000000000000007123 206.0
TLS2_k127_6880559_1 - - - - 0.00000000000000000000000000000002057 135.0
TLS2_k127_6880559_2 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 0.00000000000000000000000000173 114.0
TLS2_k127_6880559_3 RibD C-terminal domain - - - 0.00000000000000000006252 91.0
TLS2_k127_6880559_4 Bacterial regulatory proteins, luxR family - - - 0.0000000000000000002659 97.0
TLS2_k127_6880559_5 RibD C-terminal domain - - - 0.0000000003857 62.0
TLS2_k127_689365_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 481.0
TLS2_k127_689365_1 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002887 397.0
TLS2_k127_6914883_0 PEP-utilising enzyme, TIM barrel domain K01007 - 2.7.9.2 0.0 1198.0
TLS2_k127_6914883_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 2.727e-252 788.0
TLS2_k127_6914883_10 BON domain K04065 - - 0.0000000000000000000000000000000000000000000000000000000316 204.0
TLS2_k127_6914883_11 Sugar (and other) transporter K08195 - - 0.00000000000000000000000000000000000000000000000000000005363 203.0
TLS2_k127_6914883_12 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000004041 177.0
TLS2_k127_6914883_13 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000007664 167.0
TLS2_k127_6914883_14 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000003182 147.0
TLS2_k127_6914883_15 Universal stress protein - - - 0.000000000000000000000000000005503 124.0
TLS2_k127_6914883_16 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000008262 104.0
TLS2_k127_6914883_17 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0000000000000000000009769 101.0
TLS2_k127_6914883_18 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000000000000008089 99.0
TLS2_k127_6914883_19 Bacterial protein of unknown function (DUF883) - - - 0.000001297 55.0
TLS2_k127_6914883_2 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 596.0
TLS2_k127_6914883_20 IMP dehydrogenase activity - - - 0.000158 44.0
TLS2_k127_6914883_3 Putative peptidoglycan binding domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 352.0
TLS2_k127_6914883_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 293.0
TLS2_k127_6914883_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 290.0
TLS2_k127_6914883_6 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007625 277.0
TLS2_k127_6914883_7 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000239 269.0
TLS2_k127_6914883_8 nuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000003792 241.0
TLS2_k127_6914883_9 phosphoribosyl transferase K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000005334 230.0
TLS2_k127_6944289_0 Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 4.29e-214 702.0
TLS2_k127_6944289_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 304.0
TLS2_k127_6944289_2 cytochrome p450 - - - 0.00000000000000000000000000000000000000000000000000000000001178 223.0
TLS2_k127_6967817_0 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K12980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 531.0
TLS2_k127_6967817_1 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 368.0
TLS2_k127_6967817_2 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001622 270.0
TLS2_k127_6967817_3 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000001378 226.0
TLS2_k127_6967817_4 membrane - - - 0.00000000000000000000000001099 112.0
TLS2_k127_6967817_5 Redoxin - - - 0.0000000000000358 78.0
TLS2_k127_6967817_6 Involved in the tonB-independent uptake of proteins K03641,K10117 - - 0.0002689 46.0
TLS2_k127_6971806_0 Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05559 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 459.0
TLS2_k127_6971806_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 409.0
TLS2_k127_6971806_2 Prokaryotic N-terminal methylation motif K02655 - - 0.000000000000000000000000000000000000002362 152.0
TLS2_k127_6981971_0 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000001406 265.0
TLS2_k127_6981971_1 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008652 258.0
TLS2_k127_6981971_2 MoaC family K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000006954 192.0
TLS2_k127_6981971_3 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase - - - 0.000000000000000000000000000000000000000000000000003217 190.0
TLS2_k127_6993387_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.646e-274 854.0
TLS2_k127_6993387_1 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 351.0
TLS2_k127_6993387_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 324.0
TLS2_k127_6993387_3 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000004632 218.0
TLS2_k127_6993387_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000006456 170.0
TLS2_k127_7006750_0 COG2148 Sugar transferases involved in lipopolysaccharide synthesis K03606 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 412.0
TLS2_k127_7006750_1 TIGRFAM chain length determinant protein EpsF - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009457 357.0
TLS2_k127_7006750_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009626 335.0
TLS2_k127_7006750_3 Chain length determinant protein tyrosine kinase EpsG K08252 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004366 261.0
TLS2_k127_7006750_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002837 263.0
TLS2_k127_7006750_5 polysaccharide export protein K01991 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002613 255.0
TLS2_k127_7006750_6 Zinc-binding dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000001191 164.0
TLS2_k127_7006750_7 - - - - 0.000000000000000000000004476 116.0
TLS2_k127_7045071_0 Reduces the stability of FtsZ polymers in the presence of ATP K06916 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 389.0
TLS2_k127_7045071_1 Acetoacetyl-CoA synthase K01907 - 6.2.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007088 286.0
TLS2_k127_7059696_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 324.0
TLS2_k127_7059696_1 Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 295.0
TLS2_k127_7059696_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000004234 263.0
TLS2_k127_7059696_3 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000000000000000000000004564 232.0
TLS2_k127_7059696_4 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000003043 218.0
TLS2_k127_7059696_5 PFAM Smr - - - 0.0000000000000000000000000000000000000008314 154.0
TLS2_k127_7059696_6 peptidase K06194 - - 0.0000000000000000005861 93.0
TLS2_k127_7066753_0 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005619 282.0
TLS2_k127_7066753_1 CHAD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001531 260.0
TLS2_k127_7066753_2 - - - - 0.0000000000000000000000000000003097 125.0
TLS2_k127_7072901_0 - - - - 0.00004209 57.0
TLS2_k127_7072901_1 Phosphotransferase enzyme family - - - 0.0009976 49.0
TLS2_k127_7104978_0 thiamine pyrophosphate protein TPP binding domain protein K01652 - 2.2.1.6 1.249e-281 874.0
TLS2_k127_7104978_1 COG1012 NAD-dependent aldehyde dehydrogenases K13922,K15515 - 1.2.1.81,1.2.1.87 1.221e-210 664.0
TLS2_k127_7104978_2 4-hydroxyphenylpyruvate dioxygenase K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 582.0
TLS2_k127_7104978_3 HMGL-like K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 431.0
TLS2_k127_7104978_4 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004356 291.0
TLS2_k127_7104978_5 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000721 234.0
TLS2_k127_7104978_6 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000001287 220.0
TLS2_k127_7116991_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.371e-249 781.0
TLS2_k127_7116991_1 Major facilitator Superfamily K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008629 448.0
TLS2_k127_7116991_2 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000009229 266.0
TLS2_k127_7116991_3 Belongs to the MtfA family K09933 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002066 262.0
TLS2_k127_7116991_4 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000001357 168.0
TLS2_k127_7120776_0 COG0793 Periplasmic protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 376.0
TLS2_k127_7120776_1 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 339.0
TLS2_k127_7120776_2 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001378 271.0
TLS2_k127_7120776_3 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000003342 151.0
TLS2_k127_7120776_5 SnoaL-like domain - - - 0.0000000008232 67.0
TLS2_k127_7120776_6 - - - - 0.00000004199 57.0
TLS2_k127_7160417_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 5.031e-216 699.0
TLS2_k127_7160417_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 386.0
TLS2_k127_7160417_2 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 325.0
TLS2_k127_7160417_3 ErfK YbiS YcfS YnhG K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 320.0
TLS2_k127_7160417_4 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000006493 202.0
TLS2_k127_7160417_5 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000000000004069 192.0
TLS2_k127_7160417_6 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000001753 99.0
TLS2_k127_7160417_7 metal-binding, possibly nucleic acid-binding protein K07040 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000006284 72.0
TLS2_k127_7170908_0 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000001207 209.0
TLS2_k127_7170908_1 dihydrofolate reductase activity - - - 0.00000000000000000000000000000006835 124.0
TLS2_k127_7170908_2 regulator of chromosome condensation, RCC1 - - - 0.0000000000000000006412 102.0
TLS2_k127_7170908_3 hippocampus abundant transcript 1 - - - 0.00000000000222 70.0
TLS2_k127_7177996_0 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 354.0
TLS2_k127_7177996_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 300.0
TLS2_k127_7177996_2 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000003782 173.0
TLS2_k127_7214143_0 Vitamin B12 dependent methionine synthase, activation K00548 - 2.1.1.13 6.052e-249 779.0
TLS2_k127_7214143_1 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 360.0
TLS2_k127_7214143_2 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 338.0
TLS2_k127_7227990_0 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 623.0
TLS2_k127_7227990_1 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000308 63.0
TLS2_k127_7232982_0 FAD linked oxidases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 529.0
TLS2_k127_7232982_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 464.0
TLS2_k127_7232982_2 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 405.0
TLS2_k127_7232982_3 Bacterial protein of unknown function (DUF839) K07093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 390.0
TLS2_k127_7232982_5 - - - - 0.000000000421 66.0
TLS2_k127_7269917_0 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 7.393e-214 673.0
TLS2_k127_7269917_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 384.0
TLS2_k127_7269917_2 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 347.0
TLS2_k127_7269917_3 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000004069 196.0
TLS2_k127_7274998_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 568.0
TLS2_k127_7274998_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005414 498.0
TLS2_k127_7274998_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 424.0
TLS2_k127_7274998_3 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 368.0
TLS2_k127_7274998_4 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 306.0
TLS2_k127_7274998_5 FimV C-terminal K08086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004301 287.0
TLS2_k127_7274998_6 protein conserved in bacteria K03749 - - 0.000001062 59.0
TLS2_k127_7296395_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 3.748e-288 900.0
TLS2_k127_7296395_1 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 9.52e-242 766.0
TLS2_k127_7296395_2 NADH ubiquinone oxidoreductase subunit K00342 - 1.6.5.3 3.214e-236 740.0
TLS2_k127_7296395_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 562.0
TLS2_k127_7296395_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 466.0
TLS2_k127_7296395_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000006332 254.0
TLS2_k127_7296395_6 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000001691 221.0
TLS2_k127_7296395_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000001292 143.0
TLS2_k127_7296395_8 - - - - 0.00000003725 57.0
TLS2_k127_7297668_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 2.727e-268 839.0
TLS2_k127_7297668_1 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 397.0
TLS2_k127_7297668_2 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 366.0
TLS2_k127_7297668_3 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 319.0
TLS2_k127_7297668_4 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 304.0
TLS2_k127_7297668_5 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001671 261.0
TLS2_k127_7297668_6 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 0.0000000000000000000000000000000000000000000000005247 180.0
TLS2_k127_7297668_7 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.00000000000000000207 90.0
TLS2_k127_7300695_0 Alcohol dehydrogenase GroES-like domain K00055 - 1.1.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007274 525.0
TLS2_k127_7300695_1 aminopeptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 366.0
TLS2_k127_7300695_2 Carboxylesterase family K01066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 310.0
TLS2_k127_7300695_3 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000004331 184.0
TLS2_k127_7300695_4 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000000000000000009931 173.0
TLS2_k127_7300695_5 cellulase activity - - - 0.00000000000006114 85.0
TLS2_k127_7300695_6 - - - - 0.0004405 51.0
TLS2_k127_7320798_0 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 326.0
TLS2_k127_7320798_1 HemY domain protein K02498 - - 0.00000000000000000000000000000000000000000000000004929 201.0
TLS2_k127_7320798_2 Uroporphyrinogen III synthase K01719 - 4.2.1.75 0.000000000000000000000000000000000002344 147.0
TLS2_k127_7320798_3 enzyme of heme biosynthesis K02496,K13543 - 2.1.1.107,4.2.1.75 0.000000000000000000007565 105.0
TLS2_k127_7324315_0 Transposase DDE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 326.0
TLS2_k127_7324315_1 - - - - 0.00000000000000000000000000000000000000000000000000000001214 203.0
TLS2_k127_7324315_2 Belongs to the mandelate racemase muconate lactonizing enzyme family K20023 - 4.2.1.156,4.2.1.42 0.0000000000000000000000000000000000000000000000003954 184.0
TLS2_k127_7339077_0 Lytic murein transglycosylase K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 589.0
TLS2_k127_7339077_1 MgtC family K07507 - - 0.00000000000000000000000000000000000000003764 159.0
TLS2_k127_7339077_2 Domain of unknown function (DUF4136) - - - 0.00000000004131 70.0
TLS2_k127_7340366_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 443.0
TLS2_k127_7340366_1 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000004781 213.0
TLS2_k127_7372227_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 3.367e-197 623.0
TLS2_k127_7372227_1 FAD dependent oxidoreductase K09471 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 490.0
TLS2_k127_7372227_2 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 312.0
TLS2_k127_7372574_0 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008623 368.0
TLS2_k127_7372574_1 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001263 265.0
TLS2_k127_7372574_2 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006063 239.0
TLS2_k127_7372574_3 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000757 181.0
TLS2_k127_7372574_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000004707 119.0
TLS2_k127_7376265_0 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 559.0
TLS2_k127_7376265_1 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase K05921 - 4.1.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 436.0
TLS2_k127_7384893_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 591.0
TLS2_k127_7384893_1 ABC transporter K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 308.0
TLS2_k127_7384893_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003139 275.0
TLS2_k127_7384893_3 Involved in the tonB-independent uptake of proteins K03641,K10117 - - 0.000000000000000000000000000000000000000000000000000000000000000000006173 254.0
TLS2_k127_7384893_4 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000000002045 196.0
TLS2_k127_7384893_5 CHAT domain - - - 0.0000008506 60.0
TLS2_k127_73925_0 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 418.0
TLS2_k127_73925_1 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 357.0
TLS2_k127_73925_2 PFAM coenzyme PQQ synthesis D K06138 - - 0.00000000000000000000000000001097 121.0
TLS2_k127_7417271_0 Amino acid permease K03294,K16238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008734 469.0
TLS2_k127_7417271_1 Multidrug efflux pump K03327 GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0022857,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 - 0.00000000000000000000000000000000000000000000000000000000000000001273 233.0
TLS2_k127_7417271_2 Protein of unknown function (DUF2845) - - - 0.00000000000002199 79.0
TLS2_k127_7427701_0 response regulator receiver K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 544.0
TLS2_k127_7427701_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 487.0
TLS2_k127_7427701_2 Sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 424.0
TLS2_k127_7427701_3 BFD-like 2Fe-2S binding domain-containing protein K02192 - - 0.00000000001505 69.0
TLS2_k127_7427737_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.123e-294 913.0
TLS2_k127_7432593_0 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 372.0
TLS2_k127_7432593_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001157 282.0
TLS2_k127_7432593_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000004306 229.0
TLS2_k127_7432593_3 ZIP Zinc transporter - - - 0.0000314 48.0
TLS2_k127_7435449_0 Histidine kinase K02478,K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 322.0
TLS2_k127_7435449_1 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002251 278.0
TLS2_k127_7435449_2 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001196 263.0
TLS2_k127_7439136_0 Phosphatase K07093 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 336.0
TLS2_k127_7439136_1 alpha beta K06889 - - 0.00000000000000000872 90.0
TLS2_k127_744249_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 398.0
TLS2_k127_744249_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000008556 146.0
TLS2_k127_750711_0 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000000001109 236.0
TLS2_k127_750711_1 - - - - 0.000000000000000000000000002813 117.0
TLS2_k127_750711_2 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.000000000000000000003194 93.0
TLS2_k127_753337_0 PFAM Glycosyl transferase, group 1 K06338,K12995,K15521 - 2.4.1.250,2.4.1.348 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 330.0
TLS2_k127_753337_1 Polysaccharide deacetylase - - - 0.0001147 53.0
TLS2_k127_762257_0 PFAM ABC transporter K06158 - - 1.874e-223 709.0
TLS2_k127_762257_1 sensor diguanylate cyclase phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 451.0
TLS2_k127_762257_2 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000000000000575 89.0
TLS2_k127_770805_0 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 340.0
TLS2_k127_770805_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000003145 167.0
TLS2_k127_770805_2 CAAX protease self-immunity - - - 0.0000000001827 63.0
TLS2_k127_783803_0 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 505.0
TLS2_k127_783803_1 metal-dependent hydrolase of the TIM-barrel fold K10221 - 3.1.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005188 385.0
TLS2_k127_783803_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04099,K04101 - 1.13.11.57,1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000001525 244.0
TLS2_k127_783803_3 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04101 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000000000001471 237.0
TLS2_k127_783803_4 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000001774 188.0
TLS2_k127_785291_0 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000000000131 219.0
TLS2_k127_785291_1 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000003634 157.0
TLS2_k127_785291_2 secretion pathway protein K02453 - - 0.0000000000000000000000000008108 121.0
TLS2_k127_785404_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000002162 239.0
TLS2_k127_785404_1 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000001587 171.0
TLS2_k127_785404_2 Alpha beta hydrolase - - - 0.0000000006814 60.0
TLS2_k127_813680_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 608.0
TLS2_k127_813680_1 PFAM Aminotransferase class I and II K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 482.0
TLS2_k127_815978_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 426.0
TLS2_k127_815978_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006474 268.0
TLS2_k127_815978_2 - - - - 0.00000000000000000000000000000000000000000000000000000000003089 211.0
TLS2_k127_815978_3 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000005147 177.0
TLS2_k127_817707_0 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 357.0
TLS2_k127_817707_1 CHASE3 domain K05962 - 2.7.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003167 283.0
TLS2_k127_817707_2 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000003885 239.0
TLS2_k127_817707_3 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000001806 117.0
TLS2_k127_817707_4 response regulator - - - 0.0000000000000002308 85.0
TLS2_k127_817707_5 Domain of unknown function (DUF4142) K08995 - - 0.000000000001276 76.0
TLS2_k127_817707_6 Sigma-54 interaction domain - - - 0.000000000001279 74.0
TLS2_k127_817707_7 Protein required for attachment to host cells - - - 0.000000000001529 73.0
TLS2_k127_818617_0 ABC-type multidrug transport system ATPase and permease K06147 - - 2.601e-293 910.0
TLS2_k127_818617_1 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003592 261.0
TLS2_k127_834804_0 Site-specific recombinase, DNA invertase Pin - - - 2.916e-273 858.0
TLS2_k127_834804_1 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000002232 227.0
TLS2_k127_834804_3 Phage integrase family - - - 0.000000000333 60.0
TLS2_k127_853927_0 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 293.0
TLS2_k127_853927_1 Phage plasmid primase P4 family - - - 0.000000000000000000000000000000000001376 158.0
TLS2_k127_85833_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006001 301.0
TLS2_k127_859614_0 AIR synthase related protein, C-terminal K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 464.0
TLS2_k127_859614_1 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 358.0
TLS2_k127_859614_2 Belongs to the WrbA family K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003402 272.0
TLS2_k127_859614_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000001145 234.0
TLS2_k127_859614_5 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA K10763 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - 0.00000000000000000000000000000000000000000000000000000000583 206.0
TLS2_k127_859614_6 PFAM CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.0000000000000000000000000000000000001685 150.0
TLS2_k127_859614_7 protein conserved in bacteria K09938 - - 0.00000000000000000000009229 109.0
TLS2_k127_859614_8 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000005694 61.0
TLS2_k127_865159_0 Histidine kinase - - - 1.711e-198 656.0
TLS2_k127_865159_1 Belongs to the BI1 family K19416 - - 0.0000000000000000000000000000000000000000000000000000000000000000038 231.0
TLS2_k127_865159_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000003996 163.0
TLS2_k127_870731_0 Single-stranded-DNA-specific exonuclease K07462 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 617.0
TLS2_k127_870731_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 511.0
TLS2_k127_870731_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 284.0
TLS2_k127_870731_3 Protein conserved in bacteria - - - 0.00000000000000008775 92.0
TLS2_k127_870731_4 Protein of unknown function (DUF498/DUF598) - - - 0.0001312 47.0
TLS2_k127_899068_0 Major facilitator superfamily MFS_1 K02575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 506.0
TLS2_k127_899068_1 7TMR-DISM extracellular 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 490.0
TLS2_k127_899068_2 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 303.0
TLS2_k127_899068_3 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000001652 209.0
TLS2_k127_899068_4 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000000000009231 205.0
TLS2_k127_899068_5 FR47-like protein - - - 0.0000000000000000000000001064 112.0
TLS2_k127_9103_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 561.0
TLS2_k127_9103_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 335.0
TLS2_k127_9103_2 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000000000000000001385 201.0
TLS2_k127_9103_3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.000000000000000006558 88.0
TLS2_k127_9103_4 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000001231 80.0
TLS2_k127_913279_0 DNA helicase K03654 - 3.6.4.12 4.342e-248 780.0
TLS2_k127_913279_1 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 366.0
TLS2_k127_913279_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 317.0
TLS2_k127_913279_3 receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000004479 240.0
TLS2_k127_913279_4 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000002206 164.0
TLS2_k127_913279_5 PilZ domain - - - 0.0000000000004962 72.0
TLS2_k127_93057_0 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 333.0
TLS2_k127_93057_1 ECF sigma factor - - - 0.000000000000000000000000000000000000000000006456 170.0
TLS2_k127_931009_0 Histidine kinase - - - 3.248e-218 704.0
TLS2_k127_931009_1 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 343.0
TLS2_k127_931009_2 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004102 283.0
TLS2_k127_931009_3 Domain of unknown function (DUF4154) - - - 0.000000000000000000000000000000000023 142.0
TLS2_k127_931009_4 protein conserved in bacteria K09912 - - 0.0000003262 52.0
TLS2_k127_942057_0 FeS assembly ATPase SufC K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008242 385.0
TLS2_k127_942057_1 iron-sulfur cluster assembly K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 314.0
TLS2_k127_942057_2 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000008769 175.0
TLS2_k127_967451_0 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032,K13892 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 591.0
TLS2_k127_967451_1 methyl-accepting chemotaxis protein - - - 0.0000000113 59.0
TLS2_k127_977921_0 PFAM NmrA family protein K19267 - 1.6.5.2 0.0000000000000000000000000000000000000000000000001836 189.0
TLS2_k127_992454_0 Protein of unknown function (DUF815) K06923 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000958 443.0
TLS2_k127_992454_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002328 249.0
TLS2_k127_992454_2 Preprotein translocase subunit K03210 - - 0.000000000000000000000000000000000000000001944 157.0