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Overview

ID MAG04021
Name TLS2_bin.62
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Acidimicrobiia
Order UBA5794
Family UBA5794
Genus JACDBE01
Species
Assembly information
Completeness (%) 94.29
Contamination (%) 1.68
GC content (%) 69.0
N50 (bp) 38,231
Genome size (bp) 3,589,754

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3050

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1032888_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 481.0
TLS2_k127_1032888_1 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 415.0
TLS2_k127_1032888_2 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K09971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007901 288.0
TLS2_k127_1032888_3 amino acid transport K09970,K09971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001552 271.0
TLS2_k127_1032888_4 4Fe-4S dicluster domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000005286 236.0
TLS2_k127_1032888_5 PFAM FAD linked oxidase domain protein K00104,K11472 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 0.000000000000000000000000000000000000000000002573 186.0
TLS2_k127_1032888_6 Protein of unknown function (DUF3151) - - - 0.0000000000000000000000000001248 128.0
TLS2_k127_1103000_0 protein with protein kinase and helix-hairpin-helix DNA-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 388.0
TLS2_k127_1103000_1 Inner membrane component of T3SS, cytoplasmic domain K08372 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001508 269.0
TLS2_k127_1103000_2 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000691 240.0
TLS2_k127_1103000_3 alpha-L-arabinofuranosidase - - - 0.0000000000000000000000000000000000000009259 163.0
TLS2_k127_1103000_4 Protein phosphatase 2C - - - 0.000000000000000000000000000000000002705 159.0
TLS2_k127_1103000_5 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000776 118.0
TLS2_k127_1118499_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1236.0
TLS2_k127_1118499_1 Sporulation and spore germination - - - 0.00000000000000000000000000000000000002292 159.0
TLS2_k127_1195133_0 arginine K01478 - 3.5.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 368.0
TLS2_k127_1195133_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000004465 269.0
TLS2_k127_1195133_10 - - - - 0.0000001454 56.0
TLS2_k127_1195133_11 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.000003014 53.0
TLS2_k127_1195133_2 Protein of unknown function (DUF664) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006058 252.0
TLS2_k127_1195133_3 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816 - 3.6.3.20 0.0000000000000000000000000000000000000000000000000000000000000001853 237.0
TLS2_k127_1195133_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000004075 168.0
TLS2_k127_1195133_5 Beta-lactamase - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 - 0.00000000000000000000000000000000000000001699 167.0
TLS2_k127_1195133_6 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000001119 143.0
TLS2_k127_1195133_7 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000001414 107.0
TLS2_k127_1195133_8 Transposase - - - 0.000000000000000004662 95.0
TLS2_k127_1195133_9 JAB/MPN domain K21140 - 3.13.1.6 0.00000000000001712 82.0
TLS2_k127_1196032_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.35e-208 677.0
TLS2_k127_1196032_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 4.497e-208 675.0
TLS2_k127_1196032_10 Belongs to the peptidase M24B family K01271,K01274 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 342.0
TLS2_k127_1196032_11 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 338.0
TLS2_k127_1196032_12 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 327.0
TLS2_k127_1196032_13 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 336.0
TLS2_k127_1196032_14 FeS assembly ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 300.0
TLS2_k127_1196032_15 C-methyltransferase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003125 287.0
TLS2_k127_1196032_16 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000005895 191.0
TLS2_k127_1196032_17 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000002326 177.0
TLS2_k127_1196032_18 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000002756 168.0
TLS2_k127_1196032_19 Redoxin - - - 0.000000000000000000000000000000000004629 148.0
TLS2_k127_1196032_2 C-methyltransferase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 530.0
TLS2_k127_1196032_20 PFAM Disulfide bond formation protein DsbB K03611 - - 0.00000000000000000000000000000000002843 143.0
TLS2_k127_1196032_21 hydrolase of the alpha beta superfamily K07018 - - 0.000000000000000000000000003618 120.0
TLS2_k127_1196032_22 - - - - 0.00000000002272 75.0
TLS2_k127_1196032_23 - - - - 0.0004732 49.0
TLS2_k127_1196032_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006315 487.0
TLS2_k127_1196032_4 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 415.0
TLS2_k127_1196032_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000806 420.0
TLS2_k127_1196032_6 ThiF family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 395.0
TLS2_k127_1196032_7 TIGRFAM Dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 401.0
TLS2_k127_1196032_8 Nucleotidyl transferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 363.0
TLS2_k127_1196032_9 TIGRFAM 2-oxoglutarate dehydrogenase, E2 component K00658,K09699 - 2.3.1.168,2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 352.0
TLS2_k127_1196310_0 ABC transporter K06147 - - 4.893e-274 881.0
TLS2_k127_1196310_1 ABC transporter transmembrane region K06147 - - 6.194e-236 752.0
TLS2_k127_1196310_10 lipid binding K14954,K14955 GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008289,GO:0009405,GO:0009605,GO:0009607,GO:0009966,GO:0010469,GO:0010646,GO:0016020,GO:0020012,GO:0023051,GO:0030312,GO:0030545,GO:0030682,GO:0031982,GO:0035091,GO:0042783,GO:0042785,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043230,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044421,GO:0044464,GO:0048018,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051812,GO:0051832,GO:0051834,GO:0051861,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0065009,GO:0071944,GO:0075136,GO:0097367,GO:0097691,GO:0098772,GO:1903561 - 0.00000000000000000000000000000000000000000000000000000000001232 214.0
TLS2_k127_1196310_11 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000001425 227.0
TLS2_k127_1196310_12 asnC family K03718 - - 0.0000000000000000000000000000000000000000000003521 172.0
TLS2_k127_1196310_13 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000000000000000000008252 127.0
TLS2_k127_1196310_14 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000001193 123.0
TLS2_k127_1196310_15 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000000159 102.0
TLS2_k127_1196310_16 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000001995 86.0
TLS2_k127_1196310_17 PhoU domain - - - 0.00000000000007671 80.0
TLS2_k127_1196310_18 - - - - 0.0000000000135 72.0
TLS2_k127_1196310_19 - - - - 0.000001397 56.0
TLS2_k127_1196310_2 Major facilitator Superfamily - - - 1.173e-233 746.0
TLS2_k127_1196310_20 sequence-specific DNA binding - - - 0.0000403 55.0
TLS2_k127_1196310_3 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 396.0
TLS2_k127_1196310_4 CotH kinase protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 361.0
TLS2_k127_1196310_5 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009235 368.0
TLS2_k127_1196310_6 Na+/Pi-cotransporter K03324,K14683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 331.0
TLS2_k127_1196310_7 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 348.0
TLS2_k127_1196310_8 Phage tail sheath C-terminal domain K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 317.0
TLS2_k127_1196310_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002257 284.0
TLS2_k127_1314630_0 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000008381 160.0
TLS2_k127_1314630_1 Putative Flp pilus-assembly TadE/G-like - - - 0.000008983 57.0
TLS2_k127_1314630_2 TadE-like protein - - - 0.0001137 53.0
TLS2_k127_1314630_3 TadE-like protein - - - 0.000233 51.0
TLS2_k127_1349438_0 Belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 524.0
TLS2_k127_1349438_1 Aminotransferase class-III - - - 0.00000000000007421 76.0
TLS2_k127_1476433_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 3.535e-302 949.0
TLS2_k127_1476433_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 597.0
TLS2_k127_1476433_10 AAA domain (Cdc48 subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 344.0
TLS2_k127_1476433_11 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 333.0
TLS2_k127_1476433_12 PFAM cytoplasmic peptidoglycan synthetase domain protein K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 318.0
TLS2_k127_1476433_13 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 296.0
TLS2_k127_1476433_14 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001222 297.0
TLS2_k127_1476433_15 Belongs to the SEDS family K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002869 287.0
TLS2_k127_1476433_16 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008205 268.0
TLS2_k127_1476433_17 PFAM Thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000001053 220.0
TLS2_k127_1476433_18 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000003444 229.0
TLS2_k127_1476433_19 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000005533 188.0
TLS2_k127_1476433_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 588.0
TLS2_k127_1476433_20 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000003985 153.0
TLS2_k127_1476433_21 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000003621 147.0
TLS2_k127_1476433_22 Ribosomal L27 protein K02899 - - 0.0000000000000000000000000000001782 124.0
TLS2_k127_1476433_23 Sucrose-6F-phosphate phosphohydrolase K07024 - 3.1.3.24 0.00000000000000000000000000001384 130.0
TLS2_k127_1476433_24 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000001415 122.0
TLS2_k127_1476433_25 rod shape-determining protein MreC K03570 - - 0.000000000000000000000000001345 123.0
TLS2_k127_1476433_26 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000001389 122.0
TLS2_k127_1476433_28 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000005965 115.0
TLS2_k127_1476433_29 Peptidase family M23 - - - 0.000000001171 70.0
TLS2_k127_1476433_3 Glycosyl transferase 4-like domain K00696 - 2.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 551.0
TLS2_k127_1476433_30 - - - - 0.00000002755 64.0
TLS2_k127_1476433_31 rod shape-determining protein MreD K03571 - - 0.0002385 53.0
TLS2_k127_1476433_32 - - - - 0.0003352 48.0
TLS2_k127_1476433_33 - - - - 0.0009967 46.0
TLS2_k127_1476433_4 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 499.0
TLS2_k127_1476433_5 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 501.0
TLS2_k127_1476433_6 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 480.0
TLS2_k127_1476433_7 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 439.0
TLS2_k127_1476433_8 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 374.0
TLS2_k127_1476433_9 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 362.0
TLS2_k127_1479168_0 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 589.0
TLS2_k127_1479168_1 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 523.0
TLS2_k127_1479168_2 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 462.0
TLS2_k127_1479168_3 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000008386 138.0
TLS2_k127_1479168_4 ABC-2 family transporter protein K01992 - - 0.00000000000002886 77.0
TLS2_k127_1479168_5 PFAM UspA - - - 0.000000000006713 75.0
TLS2_k127_1479168_6 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K12953 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 0.00000002459 60.0
TLS2_k127_1497377_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1189.0
TLS2_k127_1497377_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 1.464e-281 902.0
TLS2_k127_1497377_10 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 466.0
TLS2_k127_1497377_11 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 444.0
TLS2_k127_1497377_12 Thimet oligopeptidase K01392,K01393 GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016567,GO:0016787,GO:0019538,GO:0023052,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032446,GO:0033218,GO:0034641,GO:0035556,GO:0036211,GO:0042277,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0070013,GO:0070647,GO:0071704,GO:0140096,GO:1901564 3.4.24.15,3.4.24.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 445.0
TLS2_k127_1497377_13 ABC transporter K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 422.0
TLS2_k127_1497377_14 Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis K14728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 402.0
TLS2_k127_1497377_15 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 395.0
TLS2_k127_1497377_16 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 372.0
TLS2_k127_1497377_17 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 363.0
TLS2_k127_1497377_18 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 354.0
TLS2_k127_1497377_19 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 362.0
TLS2_k127_1497377_2 Succinyl-CoA ligase like flavodoxin domain - - - 3.007e-233 754.0
TLS2_k127_1497377_20 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 336.0
TLS2_k127_1497377_21 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 332.0
TLS2_k127_1497377_22 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 312.0
TLS2_k127_1497377_23 SERine Proteinase INhibitors K13963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 305.0
TLS2_k127_1497377_24 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 298.0
TLS2_k127_1497377_25 Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 297.0
TLS2_k127_1497377_26 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006216 286.0
TLS2_k127_1497377_27 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001814 269.0
TLS2_k127_1497377_28 Parallel beta-helix repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000174 276.0
TLS2_k127_1497377_29 ABC transporter K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003491 264.0
TLS2_k127_1497377_3 E1-E2 ATPase K12952 - - 1.367e-230 743.0
TLS2_k127_1497377_30 chorismate binding enzyme K02552 - 5.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000008269 250.0
TLS2_k127_1497377_31 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01911 - 6.2.1.26 0.000000000000000000000000000000000000000000000000000000000000000007493 245.0
TLS2_k127_1497377_32 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.00000000000000000000000000000000000000000000000000000000000000009581 223.0
TLS2_k127_1497377_33 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000003014 239.0
TLS2_k127_1497377_34 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000003783 230.0
TLS2_k127_1497377_35 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000004012 236.0
TLS2_k127_1497377_36 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000007063 215.0
TLS2_k127_1497377_37 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000001922 212.0
TLS2_k127_1497377_38 Domain of unknown function (DUF1905) - - - 0.0000000000000000000000000000000000000000000000000000002616 207.0
TLS2_k127_1497377_39 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000000000000000000000000000000001391 199.0
TLS2_k127_1497377_4 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.367e-223 707.0
TLS2_k127_1497377_40 PDZ domain (Also known as DHR or GLGF) K08372 - - 0.0000000000000000000000000000000000000000000000000001263 207.0
TLS2_k127_1497377_41 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000000000004695 204.0
TLS2_k127_1497377_42 TIGRFAM hydrolase, TatD family K03424 - - 0.000000000000000000000000000000000000000000000004523 182.0
TLS2_k127_1497377_43 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000000000000000000000001683 174.0
TLS2_k127_1497377_44 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000008972 173.0
TLS2_k127_1497377_45 PFAM Translin K07477 - - 0.00000000000000000000000000000000000000000000009403 177.0
TLS2_k127_1497377_46 regulatory protein, arsR - - - 0.000000000000000000000000000000000000000000003762 166.0
TLS2_k127_1497377_47 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000006301 163.0
TLS2_k127_1497377_48 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000001507 160.0
TLS2_k127_1497377_49 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000003368 147.0
TLS2_k127_1497377_5 Elongation factor G, domain IV K02355 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - 3.157e-199 655.0
TLS2_k127_1497377_50 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000006587 140.0
TLS2_k127_1497377_51 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000001948 138.0
TLS2_k127_1497377_52 Transcriptional regulator, arsr family K03892 - - 0.0000000000000000000000000003017 120.0
TLS2_k127_1497377_53 Cbs domain - - - 0.0000000000000000000000000008598 120.0
TLS2_k127_1497377_54 NUDIX domain - - - 0.00000000000000000000000000125 119.0
TLS2_k127_1497377_55 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000003363 130.0
TLS2_k127_1497377_56 Protein of unknown function (DUF501) K09009 - - 0.00000000000000000000000001337 117.0
TLS2_k127_1497377_57 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000452 123.0
TLS2_k127_1497377_58 Glycosyl hydrolases family 25 - - - 0.0000000000000000000127 108.0
TLS2_k127_1497377_59 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000205 105.0
TLS2_k127_1497377_6 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009663 532.0
TLS2_k127_1497377_60 Helix-turn-helix domain - - - 0.000000000000000000466 96.0
TLS2_k127_1497377_61 AbrB family K06284 - - 0.000000000000000004777 85.0
TLS2_k127_1497377_62 Alpha beta hydrolase - - - 0.00000000000008658 84.0
TLS2_k127_1497377_63 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000002834 81.0
TLS2_k127_1497377_64 Zn peptidase - - - 0.0000000000147 77.0
TLS2_k127_1497377_65 - - - - 0.00000000005928 70.0
TLS2_k127_1497377_66 septum formation initiator K13052 - - 0.0000002019 62.0
TLS2_k127_1497377_68 Belongs to the thioredoxin family K03671 - - 0.0001153 52.0
TLS2_k127_1497377_7 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 509.0
TLS2_k127_1497377_8 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 503.0
TLS2_k127_1497377_9 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 512.0
TLS2_k127_1517606_0 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 565.0
TLS2_k127_1517606_1 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 557.0
TLS2_k127_1517606_10 PFAM peptidase C45 acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase K19200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 342.0
TLS2_k127_1517606_11 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001425 275.0
TLS2_k127_1517606_12 PFAM binding-protein-dependent transport systems inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000572 268.0
TLS2_k127_1517606_13 Bacterial extracellular solute-binding protein K11069 - - 0.000000000000000000000000000000000000000000000000000000000000000000008532 248.0
TLS2_k127_1517606_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004859 236.0
TLS2_k127_1517606_15 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000001435 226.0
TLS2_k127_1517606_16 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000008811 213.0
TLS2_k127_1517606_17 Protein of unknown function (DUF1254) - - - 0.0000000000000000000000000000000000000000000000000000000009841 207.0
TLS2_k127_1517606_18 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000001434 209.0
TLS2_k127_1517606_19 Protein of unknown function (DUF1214) - - - 0.0000000000000000000000000000000000000000000000001114 183.0
TLS2_k127_1517606_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 522.0
TLS2_k127_1517606_20 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000004561 179.0
TLS2_k127_1517606_21 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000004447 158.0
TLS2_k127_1517606_22 NLP P60 protein - - - 0.0000000000000000000000000000000000000001826 171.0
TLS2_k127_1517606_23 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000002219 120.0
TLS2_k127_1517606_24 Evidence 2b Function of strongly homologous gene K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.0000000000005795 76.0
TLS2_k127_1517606_25 YqeY-like protein K09117 - - 0.0000000924 61.0
TLS2_k127_1517606_3 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 509.0
TLS2_k127_1517606_4 Belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 505.0
TLS2_k127_1517606_5 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 477.0
TLS2_k127_1517606_6 Uncharacterised protein family (UPF0261) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006692 458.0
TLS2_k127_1517606_7 Phosphoenolpyruvate hydrolase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 425.0
TLS2_k127_1517606_8 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 377.0
TLS2_k127_1517606_9 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 371.0
TLS2_k127_1528264_0 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 323.0
TLS2_k127_1528264_1 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000557 276.0
TLS2_k127_1528264_2 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000159 279.0
TLS2_k127_1528264_3 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000002849 244.0
TLS2_k127_1528264_4 Activator of hsp90 atpase 1 family protein - - - 0.00000000000000000000000000000000000000000000000000001547 196.0
TLS2_k127_1528264_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000003532 157.0
TLS2_k127_1528264_6 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000007752 130.0
TLS2_k127_1580409_0 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 293.0
TLS2_k127_1580409_1 Catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001425 289.0
TLS2_k127_1580409_2 membrane - - - 0.00000000000000000000000000000000000000000000000002024 188.0
TLS2_k127_1580409_3 SnoaL-like domain K06893 - - 0.000000000000005211 80.0
TLS2_k127_1580409_4 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000002489 71.0
TLS2_k127_1580409_6 negative regulation of translational initiation - - - 0.00002139 55.0
TLS2_k127_1641608_0 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 365.0
TLS2_k127_1641608_1 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008007 329.0
TLS2_k127_1641608_2 Dak2 K05879 - 2.7.1.121 0.0000000000000000000000000000000000000000000000000000000000000007353 227.0
TLS2_k127_1641608_3 Dak1 domain K05878 - 2.7.1.121 0.000000000000000000000000000000000000000000000000000000002087 203.0
TLS2_k127_1644154_0 Fungalysin metallopeptidase (M36) - - - 0.0 1063.0
TLS2_k127_1644154_1 GTP cyclohydrolase II K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 456.0
TLS2_k127_1644154_10 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000003639 126.0
TLS2_k127_1644154_11 CHRD domain - - - 0.00000000000000009538 96.0
TLS2_k127_1644154_2 PFAM Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 338.0
TLS2_k127_1644154_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K01498,K11752 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005778 294.0
TLS2_k127_1644154_4 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000222 287.0
TLS2_k127_1644154_5 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000003523 232.0
TLS2_k127_1644154_6 riboflavin synthase, alpha subunit K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000005983 213.0
TLS2_k127_1644154_7 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.000000000000000000000000000000000000000000000000000000001824 219.0
TLS2_k127_1644154_8 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000002068 188.0
TLS2_k127_1644154_9 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000001625 187.0
TLS2_k127_2011125_0 - - - - 2.477e-218 723.0
TLS2_k127_2011125_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 484.0
TLS2_k127_2011125_2 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 395.0
TLS2_k127_2011125_3 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000000000000000000000001618 174.0
TLS2_k127_2011125_4 Belongs to the 5'-nucleotidase family K01081,K08693,K11751 - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 0.00000000000000000000000226 116.0
TLS2_k127_2011125_5 - - - - 0.000000000000001257 89.0
TLS2_k127_2031178_0 PFAM sodium hydrogen exchanger - - - 4.05e-219 701.0
TLS2_k127_2031178_1 Peptidase family M1 domain K08776 - - 2.789e-214 696.0
TLS2_k127_2031178_2 PFAM sodium hydrogen exchanger - - - 2.245e-211 681.0
TLS2_k127_2031178_3 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 490.0
TLS2_k127_2031178_4 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000002344 201.0
TLS2_k127_2031178_5 Short-chain alcohol dehydrogenase K16066 - 1.1.1.381 0.0000000000000000001733 89.0
TLS2_k127_2031178_6 response to water deprivation - - - 0.000001342 55.0
TLS2_k127_2138670_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 9.744e-273 861.0
TLS2_k127_2138670_1 transposase IS116 IS110 IS902 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 532.0
TLS2_k127_2138670_10 DNA-binding transcription factor activity - - - 0.00000000000007782 82.0
TLS2_k127_2138670_11 lactoylglutathione lyase activity - - - 0.00000000008998 67.0
TLS2_k127_2138670_12 membrane - - - 0.0000000002076 70.0
TLS2_k127_2138670_13 transposase - - - 0.0000000002234 70.0
TLS2_k127_2138670_14 Transposase and inactivated derivatives - - - 0.000000007407 57.0
TLS2_k127_2138670_15 Transport permease protein K01992,K18233 - - 0.000002667 54.0
TLS2_k127_2138670_2 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000462 279.0
TLS2_k127_2138670_3 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000004986 185.0
TLS2_k127_2138670_4 Transcriptional regulator PadR-like family K10947 - - 0.000000000000000000000000000000000000000000003443 167.0
TLS2_k127_2138670_5 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000001295 140.0
TLS2_k127_2138670_6 Transposase - - - 0.000000000000000000000000007462 121.0
TLS2_k127_2138670_7 Alcohol dehydrogenase GroES-associated - - - 0.000000000000000006493 83.0
TLS2_k127_2138670_8 Uncharacterized protein conserved in bacteria (DUF2188) - - - 0.00000000000000003866 83.0
TLS2_k127_2138670_9 Transposase - - - 0.00000000000000009465 81.0
TLS2_k127_2183012_0 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 349.0
TLS2_k127_2183012_1 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000002412 206.0
TLS2_k127_2183012_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000891 211.0
TLS2_k127_2183012_3 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000001694 194.0
TLS2_k127_2183012_4 Transcriptional regulator - - - 0.0000000000000000000000000000002703 125.0
TLS2_k127_2183012_5 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000005373 108.0
TLS2_k127_2183012_8 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000001311 63.0
TLS2_k127_2200345_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 340.0
TLS2_k127_2200345_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000000000001628 145.0
TLS2_k127_2200345_2 - - - - 0.000000000000000746 85.0
TLS2_k127_2200345_3 Nucleotidyltransferase domain K07075 - - 0.000000000307 69.0
TLS2_k127_2200345_4 metalloendopeptidase activity K03799 - - 0.000000004624 69.0
TLS2_k127_2217494_0 Dehydrogenase E1 component K00164,K01616 - 1.2.4.2,4.1.1.71 0.0 1260.0
TLS2_k127_2217494_1 4Fe-4S dicluster domain - - - 2.977e-254 804.0
TLS2_k127_2217494_10 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 599.0
TLS2_k127_2217494_11 ABC transporter related K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007533 581.0
TLS2_k127_2217494_12 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K05565,K14086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009485 572.0
TLS2_k127_2217494_13 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 533.0
TLS2_k127_2217494_14 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 535.0
TLS2_k127_2217494_15 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 500.0
TLS2_k127_2217494_16 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 499.0
TLS2_k127_2217494_17 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 456.0
TLS2_k127_2217494_18 belongs to the sigma-70 factor family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 451.0
TLS2_k127_2217494_19 helicase superfamily c-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 440.0
TLS2_k127_2217494_2 DNA helicase K03654 - 3.6.4.12 9.508e-217 692.0
TLS2_k127_2217494_20 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 436.0
TLS2_k127_2217494_21 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 422.0
TLS2_k127_2217494_22 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 409.0
TLS2_k127_2217494_23 PFAM DAHP synthetase I K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 410.0
TLS2_k127_2217494_24 Peptidase family M20/M25/M40 K01436,K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 364.0
TLS2_k127_2217494_25 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 351.0
TLS2_k127_2217494_26 Phosphorylase superfamily K03784 GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 347.0
TLS2_k127_2217494_27 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 351.0
TLS2_k127_2217494_28 Na+/H+ antiporter 1 K03313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 345.0
TLS2_k127_2217494_29 Peptidase dimerisation domain K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 334.0
TLS2_k127_2217494_3 LVIVD repeat - - - 3.923e-208 664.0
TLS2_k127_2217494_30 ABC transporter substrate-binding protein PnrA-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 327.0
TLS2_k127_2217494_31 Protein of unknown function (DUF3376) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 344.0
TLS2_k127_2217494_32 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 301.0
TLS2_k127_2217494_33 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 295.0
TLS2_k127_2217494_34 YibE F family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005142 261.0
TLS2_k127_2217494_35 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007785 253.0
TLS2_k127_2217494_36 N-acetylmuramoyl-L-alanine amidase K01448 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000003497 248.0
TLS2_k127_2217494_37 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003886 239.0
TLS2_k127_2217494_38 PFAM pfkB family carbohydrate kinase K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000002788 236.0
TLS2_k127_2217494_39 MDMPI C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008412 230.0
TLS2_k127_2217494_4 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity K03583 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.5 2.627e-207 684.0
TLS2_k127_2217494_40 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000001356 228.0
TLS2_k127_2217494_41 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000009003 212.0
TLS2_k127_2217494_42 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.0000000000000000000000000000000000000000000000000000003353 207.0
TLS2_k127_2217494_43 queuosine salvage K09125 - - 0.000000000000000000000000000000000000000000000000000005912 207.0
TLS2_k127_2217494_44 Prephenate dehydratase K04518,K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000003223 191.0
TLS2_k127_2217494_45 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.00000000000000000000000000000000000000000000000001977 184.0
TLS2_k127_2217494_46 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000001336 178.0
TLS2_k127_2217494_47 DNA recombination-mediator protein A - - - 0.000000000000000000000000000000000000000000000649 179.0
TLS2_k127_2217494_48 FR47-like protein - - - 0.000000000000000000000000000000000000000000001315 176.0
TLS2_k127_2217494_49 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000000000000008265 167.0
TLS2_k127_2217494_5 PD-(D/E)XK nuclease superfamily K03582 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.1.11.5 6.77e-198 667.0
TLS2_k127_2217494_50 protein conserved in cyanobacteria - - - 0.0000000000000000000000000000000000000000001411 165.0
TLS2_k127_2217494_51 amino acid-binding ACT domain protein K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000004213 177.0
TLS2_k127_2217494_52 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000001275 162.0
TLS2_k127_2217494_53 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000001294 166.0
TLS2_k127_2217494_54 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.0000000000000000000000000000000000000008693 152.0
TLS2_k127_2217494_55 regulation of cellular protein catabolic process - GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - 0.00000000000000000000000000000000000003791 148.0
TLS2_k127_2217494_56 MFS_1 like family - - - 0.0000000000000000000000000000000000003221 157.0
TLS2_k127_2217494_57 Domain of unknown function (DUF4332) - - - 0.0000000000000000000000000000000000007956 143.0
TLS2_k127_2217494_58 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K05565,K14086 - - 0.0000000000000000000000000000000007228 149.0
TLS2_k127_2217494_59 YCII-related domain - - - 0.000000000000000000000000000000001341 136.0
TLS2_k127_2217494_6 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 7.208e-196 646.0
TLS2_k127_2217494_60 ferredoxin like protein - - - 0.00000000000000000000000000000000669 133.0
TLS2_k127_2217494_61 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000008093 146.0
TLS2_k127_2217494_62 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.00000000000000000000000000000007559 136.0
TLS2_k127_2217494_63 PFAM Helix-turn-helix - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000191 130.0
TLS2_k127_2217494_64 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.0000000000000000000000000000006134 134.0
TLS2_k127_2217494_65 Phage shock protein A (IM30), suppresses sigma54-dependent transcription K03969 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000004894 130.0
TLS2_k127_2217494_66 hydrolase activity, acting on ester bonds K08680 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016829,GO:0016835,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0070205,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.99.20 0.00000000000000000000000000001196 129.0
TLS2_k127_2217494_67 CGNR zinc finger - - - 0.0000000000000000000000000001568 126.0
TLS2_k127_2217494_68 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000001883 117.0
TLS2_k127_2217494_69 Belongs to the ompA family K03286 - - 0.000000000000000000000000001658 125.0
TLS2_k127_2217494_7 DNA polymerase beta thumb K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 651.0
TLS2_k127_2217494_70 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000001749 108.0
TLS2_k127_2217494_71 DNA-templated transcription, initiation K03088 - - 0.000000000000000000004523 98.0
TLS2_k127_2217494_72 monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.00000000000000000002965 100.0
TLS2_k127_2217494_73 Electron transfer DM13 - - - 0.00000000000000000008823 97.0
TLS2_k127_2217494_74 Transcription factor WhiB - - - 0.000000000000000002672 87.0
TLS2_k127_2217494_75 Na+/H+ ion antiporter subunit K05569 - - 0.00000000000000001784 91.0
TLS2_k127_2217494_76 Domain of unknown function (DUF1992) - - - 0.000000000000003178 79.0
TLS2_k127_2217494_77 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.000000000004482 76.0
TLS2_k127_2217494_78 - - - - 0.0000000003376 71.0
TLS2_k127_2217494_79 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.00000004526 54.0
TLS2_k127_2217494_8 Acetyl-CoA dehydrogenase C-terminal like K20035 - - 1.755e-194 626.0
TLS2_k127_2217494_80 Domain of unknown function (DUF2017) - - - 0.000002024 59.0
TLS2_k127_2217494_81 PFAM multiple resistance and pH regulation protein F K05570 - - 0.000004374 58.0
TLS2_k127_2217494_82 - - - - 0.000006327 51.0
TLS2_k127_2217494_83 - - - - 0.0001516 48.0
TLS2_k127_2217494_84 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.0006879 45.0
TLS2_k127_2217494_9 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006405 604.0
TLS2_k127_221938_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 619.0
TLS2_k127_221938_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 322.0
TLS2_k127_2270607_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 5.007e-320 1007.0
TLS2_k127_2270607_1 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009999 471.0
TLS2_k127_2270607_2 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006313 284.0
TLS2_k127_2270607_3 Protein of unknown function (DUF983) - - - 0.00000000000000000007373 104.0
TLS2_k127_2270607_4 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000197 97.0
TLS2_k127_2270607_5 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000003384 76.0
TLS2_k127_2270607_6 Metallo-peptidase family M12 - - - 0.0000000001343 71.0
TLS2_k127_2270607_7 N-terminal Region. This family is found at the N-terminus of a number of subtilisins. It is cleaved prior to activation of the enzyme - - - 0.0002513 52.0
TLS2_k127_2339755_0 B12 binding domain K00548 - 2.1.1.13 0.0 1583.0
TLS2_k127_2339755_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 2.588e-301 957.0
TLS2_k127_2339755_10 Homocysteine S-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008856 377.0
TLS2_k127_2339755_11 Bacterial extracellular solute-binding protein K02064 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 360.0
TLS2_k127_2339755_12 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 346.0
TLS2_k127_2339755_13 Rhs element Vgr protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 319.0
TLS2_k127_2339755_14 Belongs to the ABC transporter superfamily K02052,K02062 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 308.0
TLS2_k127_2339755_15 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005499 275.0
TLS2_k127_2339755_16 Cytidine monophosphokinase K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000002796 253.0
TLS2_k127_2339755_17 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003809 271.0
TLS2_k127_2339755_18 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008093 252.0
TLS2_k127_2339755_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001026 237.0
TLS2_k127_2339755_2 Phage tail sheath C-terminal domain K06907 - - 8.17e-204 647.0
TLS2_k127_2339755_20 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000261 225.0
TLS2_k127_2339755_21 O-methyltransferase K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000000002956 212.0
TLS2_k127_2339755_22 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000234 223.0
TLS2_k127_2339755_23 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000003409 207.0
TLS2_k127_2339755_24 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000002934 193.0
TLS2_k127_2339755_25 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000004908 170.0
TLS2_k127_2339755_26 Gene 25-like lysozyme K06903 - - 0.0000000000000000000000000000000000000000000009325 172.0
TLS2_k127_2339755_27 - - - - 0.00000000000000000000000000000000000000000004305 164.0
TLS2_k127_2339755_28 Iron-storage protein K02217 - 1.16.3.2 0.0000000000000000000000000000000000000009723 170.0
TLS2_k127_2339755_29 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000003811 152.0
TLS2_k127_2339755_3 Baseplate J-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 617.0
TLS2_k127_2339755_30 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000003723 139.0
TLS2_k127_2339755_31 cell redox homeostasis K03671 - - 0.00000000000000000000000000000001906 133.0
TLS2_k127_2339755_32 Putative glycolipid-binding K09957 - - 0.0000000000000000000000000000003845 130.0
TLS2_k127_2339755_33 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000001932 139.0
TLS2_k127_2339755_34 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.00000000000000000000000001494 117.0
TLS2_k127_2339755_35 - - - - 0.000000000000000000000002659 108.0
TLS2_k127_2339755_36 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000328 97.0
TLS2_k127_2339755_37 PIN domain - - - 0.000000000000000000852 94.0
TLS2_k127_2339755_38 - - - - 0.00000000000000003769 89.0
TLS2_k127_2339755_39 AntiSigma factor - - - 0.00000000000000005406 94.0
TLS2_k127_2339755_4 Aminotransferase K00812,K14260,K14267 - 2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 548.0
TLS2_k127_2339755_40 - - - - 0.00000000000000009124 82.0
TLS2_k127_2339755_41 PFAM amino acid-binding ACT domain protein - - - 0.00000000000005083 83.0
TLS2_k127_2339755_42 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000001082 82.0
TLS2_k127_2339755_43 Carboxypeptidase regulatory-like domain - - - 0.0000000000004703 84.0
TLS2_k127_2339755_44 - - - - 0.0000000000004755 76.0
TLS2_k127_2339755_45 Tail protein - - - 0.0000000000008042 78.0
TLS2_k127_2339755_46 Clp amino terminal domain, pathogenicity island component - - - 0.000000000008361 75.0
TLS2_k127_2339755_48 Domain of unknown function (DUF4157) - - - 0.00000001913 63.0
TLS2_k127_2339755_49 Conserved repeat domain - - - 0.0002121 54.0
TLS2_k127_2339755_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 549.0
TLS2_k127_2339755_50 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0008761 50.0
TLS2_k127_2339755_6 ABC-type Fe3 transport system permease component K02011,K02063 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 533.0
TLS2_k127_2339755_7 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 511.0
TLS2_k127_2339755_8 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007491 471.0
TLS2_k127_2339755_9 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 462.0
TLS2_k127_2347897_0 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 0.0 1272.0
TLS2_k127_2347897_1 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - 5.873e-201 632.0
TLS2_k127_2347897_10 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 330.0
TLS2_k127_2347897_11 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 339.0
TLS2_k127_2347897_12 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 301.0
TLS2_k127_2347897_13 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002524 296.0
TLS2_k127_2347897_14 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007057 290.0
TLS2_k127_2347897_15 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001083 274.0
TLS2_k127_2347897_16 N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009282 269.0
TLS2_k127_2347897_17 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000001336 242.0
TLS2_k127_2347897_18 ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000003269 239.0
TLS2_k127_2347897_19 Putative glycosyl hydrolase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003232 249.0
TLS2_k127_2347897_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 583.0
TLS2_k127_2347897_20 Sir2 family K12410 - - 0.0000000000000000000000000000000000000000000000000000000000001412 224.0
TLS2_k127_2347897_21 PFAM Glycosyl transferase, group 1 K19424 - - 0.000000000000000000000000000000000000000000000000000000000007336 222.0
TLS2_k127_2347897_22 Isochorismatase family K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.00000000000000000000000000000000000000000000000000000000002765 213.0
TLS2_k127_2347897_23 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000000000000000000000000000644 216.0
TLS2_k127_2347897_24 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000009723 212.0
TLS2_k127_2347897_25 ABC transporter K06147 - - 0.0000000000000000000000000000000000000000000000000000308 191.0
TLS2_k127_2347897_26 - - - - 0.0000000000000000000000000000000000000000000000000004279 205.0
TLS2_k127_2347897_27 Sh3 type 3 domain protein K02450,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000139 172.0
TLS2_k127_2347897_28 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000001471 167.0
TLS2_k127_2347897_29 NifU-like N terminal domain K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.00000000000000000000000000000000004545 142.0
TLS2_k127_2347897_3 Pyridoxal-phosphate dependent enzyme K01505,K05396 - 3.5.99.7,4.4.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 527.0
TLS2_k127_2347897_30 Glycosyl transferases group 1 - - - 0.000000000000000000000000000001032 136.0
TLS2_k127_2347897_31 Major Facilitator Superfamily - - - 0.000000000000000000000000000003455 139.0
TLS2_k127_2347897_32 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000177 134.0
TLS2_k127_2347897_33 Rieske-like [2Fe-2S] domain K05710 - - 0.00000000000000000000000000191 116.0
TLS2_k127_2347897_34 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000002039 127.0
TLS2_k127_2347897_35 COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component K09014 - - 0.000000000000000000009192 91.0
TLS2_k127_2347897_36 - - - - 0.00000000000000000006786 95.0
TLS2_k127_2347897_37 Peptidase family M23 K21472 - - 0.0000000000000000009547 100.0
TLS2_k127_2347897_38 PFAM CBS domain - - - 0.000000000000004443 81.0
TLS2_k127_2347897_39 - - - - 0.000000003374 63.0
TLS2_k127_2347897_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 507.0
TLS2_k127_2347897_40 IgA Peptidase M64 - - - 0.0000003447 64.0
TLS2_k127_2347897_41 NmrA-like family - - - 0.000006082 55.0
TLS2_k127_2347897_5 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 494.0
TLS2_k127_2347897_6 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 405.0
TLS2_k127_2347897_7 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 360.0
TLS2_k127_2347897_8 oxidase, subunit K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 336.0
TLS2_k127_2347897_9 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 324.0
TLS2_k127_2382791_0 sulfurtransferase - - - 0.0000000000000000000000000000000000008674 144.0
TLS2_k127_2382791_1 PFAM cysteine dioxygenase type I - - - 0.000000000000000000000000008776 117.0
TLS2_k127_2382791_2 ABC transporter K15553 - - 0.0000000000000000006438 91.0
TLS2_k127_2399343_0 Trimethylamine methyltransferase (MTTB) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000587 422.0
TLS2_k127_2399343_1 transcriptional regulator - - - 0.0000000000000000000000000000000001087 143.0
TLS2_k127_2399343_2 Protein of unknown function (DUF3048) C-terminal domain - - - 0.00000000000000008424 86.0
TLS2_k127_2399343_4 PFAM ACT domain - - - 0.00000000002897 70.0
TLS2_k127_2473883_0 glucose sorbosone - - - 3.699e-211 664.0
TLS2_k127_2473883_1 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 390.0
TLS2_k127_2473883_2 transcriptional regulator - - - 0.000000000000000000000000003896 117.0
TLS2_k127_2473883_3 Phosphotransferase enzyme family - - - 0.0000000000000001721 81.0
TLS2_k127_2473883_4 - - - - 0.00000000000002319 82.0
TLS2_k127_2473883_5 transposase and inactivated derivatives, IS30 family - - - 0.0002787 48.0
TLS2_k127_2489359_0 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 460.0
TLS2_k127_2489359_1 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006101 340.0
TLS2_k127_2489359_2 cytochrome P450 K21034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003355 260.0
TLS2_k127_2489359_3 Divergent 4Fe-4S mono-cluster - - - 0.00000001974 58.0
TLS2_k127_2489359_4 Platelet-activating factor acetylhydrolase, isoform II - - - 0.000003976 53.0
TLS2_k127_2526881_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.078e-221 711.0
TLS2_k127_2526881_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 315.0
TLS2_k127_2526881_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000001635 237.0
TLS2_k127_2526881_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000003122 180.0
TLS2_k127_2526881_4 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000000003774 154.0
TLS2_k127_2526881_5 Pkd domain containing protein - - - 0.00000000000001399 85.0
TLS2_k127_2664666_0 Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons K01563 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009074 433.0
TLS2_k127_2664666_1 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 374.0
TLS2_k127_2664666_2 Extracellular solute-binding protein, family 5 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 301.0
TLS2_k127_2667738_0 Zinc carboxypeptidase - - - 8.006e-204 667.0
TLS2_k127_2667738_1 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 469.0
TLS2_k127_2667738_2 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 334.0
TLS2_k127_2667738_3 transcriptional regulator - - - 0.0000000000000000000000000000000000001309 153.0
TLS2_k127_2667738_4 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000000000001638 151.0
TLS2_k127_2667738_5 TIGRFAM TIGR03943 family protein - - - 0.00000000000000000000000000000006692 139.0
TLS2_k127_2667738_6 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.000000000009387 79.0
TLS2_k127_2667738_7 - - - - 0.000000004842 66.0
TLS2_k127_2857984_0 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 1.653e-233 758.0
TLS2_k127_2857984_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 2.01e-199 629.0
TLS2_k127_2857984_10 Phospholipid-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000911 277.0
TLS2_k127_2857984_11 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000231 277.0
TLS2_k127_2857984_12 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000004362 273.0
TLS2_k127_2857984_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004548 267.0
TLS2_k127_2857984_14 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000002704 253.0
TLS2_k127_2857984_15 COG2515 1-aminocyclopropane-1-carboxylate deaminase K05396 - 4.4.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000008666 248.0
TLS2_k127_2857984_16 polyphosphate glucokinase K00845,K00886 - 2.7.1.2,2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000001035 260.0
TLS2_k127_2857984_17 hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000665 229.0
TLS2_k127_2857984_18 Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - - 0.000000000000000000000000000000000000000000000000000003486 198.0
TLS2_k127_2857984_19 PFAM regulatory protein, MerR - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000003207 190.0
TLS2_k127_2857984_2 Acyl-CoA dehydrogenase, C-terminal domain K00248,K11410 GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 569.0
TLS2_k127_2857984_20 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000003764 193.0
TLS2_k127_2857984_21 PFAM Uncharacterised ACR, COG1259 K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000006911 181.0
TLS2_k127_2857984_22 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000002829 171.0
TLS2_k127_2857984_23 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000003476 166.0
TLS2_k127_2857984_24 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000007048 170.0
TLS2_k127_2857984_25 PRC-barrel domain - - - 0.0000000000000000000000000000000000000000859 162.0
TLS2_k127_2857984_26 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000003178 159.0
TLS2_k127_2857984_27 phosphoesterase, PA-phosphatase K19302 - 3.6.1.27 0.0000000000000000000000000000000000000111 156.0
TLS2_k127_2857984_28 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000008466 160.0
TLS2_k127_2857984_29 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000003606 141.0
TLS2_k127_2857984_3 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 527.0
TLS2_k127_2857984_30 Cytidylate kinase-like family K00760 - 2.4.2.8 0.0000000000000000000000000000008809 134.0
TLS2_k127_2857984_31 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.00000000000000000000000000004547 125.0
TLS2_k127_2857984_32 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000009543 112.0
TLS2_k127_2857984_33 - - - - 0.0000000000000000000003893 100.0
TLS2_k127_2857984_34 - - - - 0.0000000000000000005398 99.0
TLS2_k127_2857984_35 PFAM Endonuclease exonuclease phosphatase - - - 0.000000000002009 79.0
TLS2_k127_2857984_36 hydrolase K01048 - 3.1.1.5 0.00003883 50.0
TLS2_k127_2857984_37 TrkA-C domain - - - 0.0001945 46.0
TLS2_k127_2857984_38 Pectate lyase superfamily protein - - - 0.0004087 53.0
TLS2_k127_2857984_39 - - - - 0.0007525 51.0
TLS2_k127_2857984_4 Belongs to the DegT DnrJ EryC1 family K19430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 406.0
TLS2_k127_2857984_5 Adenosine/AMP deaminase K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000674 339.0
TLS2_k127_2857984_6 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008566 330.0
TLS2_k127_2857984_8 Glycine cleavage system T protein K00605 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 301.0
TLS2_k127_2857984_9 Drug resistance transporter, bcr cfla subfamily K07552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003522 288.0
TLS2_k127_2880465_0 Belongs to the ATP-dependent AMP-binding enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 506.0
TLS2_k127_2880465_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 518.0
TLS2_k127_2880465_10 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001019 256.0
TLS2_k127_2880465_11 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000001162 226.0
TLS2_k127_2880465_12 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000668 229.0
TLS2_k127_2880465_13 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000002157 214.0
TLS2_k127_2880465_14 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000008997 180.0
TLS2_k127_2880465_15 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000003969 168.0
TLS2_k127_2880465_16 polysaccharide deacetylase - - - 0.000000000000000000000000000000000004774 147.0
TLS2_k127_2880465_17 lipolytic protein G-D-S-L family K00612,K01728 - 4.2.2.2 0.0000000000000000002986 98.0
TLS2_k127_2880465_18 Glycosyltransferase Family 4 - - - 0.0000000000000165 87.0
TLS2_k127_2880465_19 G-rich domain on putative tyrosine kinase - - - 0.0000000004849 73.0
TLS2_k127_2880465_2 Tryptophan halogenase K16033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 437.0
TLS2_k127_2880465_20 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000005044 61.0
TLS2_k127_2880465_3 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 428.0
TLS2_k127_2880465_4 Polysaccharide biosynthesis protein K15912 - 4.2.1.135 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 387.0
TLS2_k127_2880465_5 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 386.0
TLS2_k127_2880465_6 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 317.0
TLS2_k127_2880465_7 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004215 289.0
TLS2_k127_2880465_8 metallopeptidase activity K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004783 289.0
TLS2_k127_2880465_9 Parallel beta-helix repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002089 282.0
TLS2_k127_2910171_0 Glucose / Sorbosone dehydrogenase - - - 3.456e-222 727.0
TLS2_k127_2910171_1 ketone body catabolic process K01026 - 2.8.3.1 2.409e-210 668.0
TLS2_k127_2910171_10 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 361.0
TLS2_k127_2910171_11 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00874 - 2.7.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 340.0
TLS2_k127_2910171_12 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009511 306.0
TLS2_k127_2910171_13 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 309.0
TLS2_k127_2910171_14 Amino acid amide ABC transporter, ATP-binding protein, 1, HAAT family K01995,K11957 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001978 284.0
TLS2_k127_2910171_15 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003079 283.0
TLS2_k127_2910171_16 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002339 269.0
TLS2_k127_2910171_17 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005185 272.0
TLS2_k127_2910171_18 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003895 277.0
TLS2_k127_2910171_19 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000001395 260.0
TLS2_k127_2910171_2 GTP-binding protein TypA K06207 - - 2.318e-204 655.0
TLS2_k127_2910171_20 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) - - - 0.0000000000000000000000000000000000000000000000000000000000000005713 230.0
TLS2_k127_2910171_21 PFAM KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000000000000000000000009781 225.0
TLS2_k127_2910171_22 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000001486 222.0
TLS2_k127_2910171_23 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000001612 216.0
TLS2_k127_2910171_24 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000001247 205.0
TLS2_k127_2910171_25 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000006357 206.0
TLS2_k127_2910171_26 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.0000000000000000000000000000000000000000002241 179.0
TLS2_k127_2910171_27 - - - - 0.000000000000000000000000000000000000000001374 170.0
TLS2_k127_2910171_28 isoleucine patch - - - 0.0000000000000000000000000000000000000001682 155.0
TLS2_k127_2910171_29 B12 binding domain - - - 0.000000000000000000000000000000000000002257 160.0
TLS2_k127_2910171_3 Glycosyl Hydrolase Family 88 K18581 - 3.2.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005577 611.0
TLS2_k127_2910171_30 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000919 133.0
TLS2_k127_2910171_31 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000006373 143.0
TLS2_k127_2910171_32 Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - 0.0000000000000000000000000000252 122.0
TLS2_k127_2910171_33 PFAM Phosphotransferase enzyme family - - - 0.00000000000000000000000003257 124.0
TLS2_k127_2910171_34 Blue (Type 1) copper domain protein - - - 0.00000000000000000000008167 103.0
TLS2_k127_2910171_35 CHRD domain - - - 0.00000000000000000003809 92.0
TLS2_k127_2910171_36 Bacterial antitoxin of type II TA system, VapB - GO:0006417,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045727,GO:0045927,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:2000112 - 0.000000000000000005394 89.0
TLS2_k127_2910171_37 PFAM blue (type 1) copper domain protein - - - 0.000000000000002489 90.0
TLS2_k127_2910171_38 - - - - 0.00000000000002483 76.0
TLS2_k127_2910171_39 Fungalysin metallopeptidase (M36) - - - 0.00000000000007977 86.0
TLS2_k127_2910171_4 Nad-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 488.0
TLS2_k127_2910171_40 EamA-like transporter family K11939 - - 0.0008567 50.0
TLS2_k127_2910171_5 D-isomer specific 2-hydroxyacid dehydrogenase K03778 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006067,GO:0006082,GO:0006083,GO:0006089,GO:0006090,GO:0006091,GO:0006103,GO:0006105,GO:0006113,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008720,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015942,GO:0015980,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019318,GO:0019362,GO:0019637,GO:0019660,GO:0019664,GO:0019666,GO:0019693,GO:0019752,GO:0032787,GO:0034308,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0050896,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0070404,GO:0071704,GO:0072521,GO:0072524,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901615 1.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 436.0
TLS2_k127_2910171_6 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 429.0
TLS2_k127_2910171_7 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006512 417.0
TLS2_k127_2910171_8 helix_turn _helix lactose operon repressor K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 371.0
TLS2_k127_2910171_9 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000082 361.0
TLS2_k127_2910376_0 Belongs to the peptidase S8 family - - - 7.949e-200 661.0
TLS2_k127_2910376_1 DUF1704 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 495.0
TLS2_k127_2910376_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001729 265.0
TLS2_k127_2910376_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000001436 220.0
TLS2_k127_2910376_12 MarR family - - - 0.00000000000000000000000000000000000000000000000000003676 193.0
TLS2_k127_2910376_13 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000000000000000004544 175.0
TLS2_k127_2910376_14 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.00000000000000000000000000001135 131.0
TLS2_k127_2910376_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 - 1.6.5.3 0.0000000000000000000000000005753 129.0
TLS2_k127_2910376_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000003405 113.0
TLS2_k127_2910376_17 NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient K05574 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008137,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015979,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.00000000000000000000006465 103.0
TLS2_k127_2910376_18 - - - - 0.00000000000000000001258 96.0
TLS2_k127_2910376_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 504.0
TLS2_k127_2910376_3 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 468.0
TLS2_k127_2910376_4 Exporter of polyketide K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006622 457.0
TLS2_k127_2910376_5 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 433.0
TLS2_k127_2910376_6 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007986 437.0
TLS2_k127_2910376_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 426.0
TLS2_k127_2910376_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000897 314.0
TLS2_k127_2910376_9 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001831 280.0
TLS2_k127_2914374_0 Carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 624.0
TLS2_k127_2914374_1 ABC-type sugar transport system, permease component K10234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 335.0
TLS2_k127_2914374_2 PFAM Binding-protein-dependent transport system inner membrane component K02025,K10233 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 324.0
TLS2_k127_2914374_3 ABC-type sugar transport system periplasmic component K10232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002425 295.0
TLS2_k127_2914374_4 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007485 270.0
TLS2_k127_2914374_5 EamA-like transporter family - - - 0.0000000000008722 78.0
TLS2_k127_2919967_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 408.0
TLS2_k127_2919967_1 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004399 262.0
TLS2_k127_2919967_2 Abc-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000003786 228.0
TLS2_k127_2919967_3 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000006941 202.0
TLS2_k127_2919967_4 Abc-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000004879 204.0
TLS2_k127_2919967_5 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000003294 207.0
TLS2_k127_2948426_0 IgA Peptidase M64 - - - 1.439e-256 817.0
TLS2_k127_2948426_1 PFAM major facilitator superfamily MFS_1 K08167 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 587.0
TLS2_k127_2948426_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000005203 174.0
TLS2_k127_2948426_11 SnoaL-like domain - - - 0.000000000000000000000000000000000000000001872 162.0
TLS2_k127_2948426_12 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000002842 159.0
TLS2_k127_2948426_13 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000008682 146.0
TLS2_k127_2948426_14 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000002286 119.0
TLS2_k127_2948426_15 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000001933 87.0
TLS2_k127_2948426_16 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000009801 91.0
TLS2_k127_2948426_17 - - - - 0.000000005924 63.0
TLS2_k127_2948426_18 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000001144 58.0
TLS2_k127_2948426_19 Aldolase/RraA K10218 - 4.1.3.17 0.0007442 43.0
TLS2_k127_2948426_2 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 500.0
TLS2_k127_2948426_3 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 430.0
TLS2_k127_2948426_4 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 402.0
TLS2_k127_2948426_5 Belongs to the FPP GGPP synthase family K13787,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 351.0
TLS2_k127_2948426_6 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 298.0
TLS2_k127_2948426_7 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001032 290.0
TLS2_k127_2948426_8 pyridoxamine 5-phosphate K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000501 264.0
TLS2_k127_2948426_9 EamA-like transporter family K15269 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008495 250.0
TLS2_k127_2965977_0 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 0.0 1361.0
TLS2_k127_2965977_1 K+ potassium transporter K03549 - - 2.195e-213 681.0
TLS2_k127_2965977_2 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 449.0
TLS2_k127_2965977_3 reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 353.0
TLS2_k127_2965977_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 343.0
TLS2_k127_2965977_5 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000003787 237.0
TLS2_k127_2965977_6 Conserved protein - - - 0.000000000000000000008116 97.0
TLS2_k127_3012748_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 7.324e-258 801.0
TLS2_k127_3012748_1 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 3e-200 652.0
TLS2_k127_3012748_10 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000003322 180.0
TLS2_k127_3012748_11 ferredoxin K05337 - - 0.000000000000000000000000000115 118.0
TLS2_k127_3012748_12 Peptidoglycan binding domain - - - 0.00000000000000000000376 106.0
TLS2_k127_3012748_13 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.0000000000000000002261 101.0
TLS2_k127_3012748_14 Phage integrase family - - - 0.00001482 52.0
TLS2_k127_3012748_2 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 576.0
TLS2_k127_3012748_3 Dihydroxyacetone kinase DhaK, subunit K05878 - 2.7.1.121 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 512.0
TLS2_k127_3012748_4 Belongs to the GPAT DAPAT family K00631 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 444.0
TLS2_k127_3012748_5 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 377.0
TLS2_k127_3012748_6 phosphate starvation-inducible protein PhoH K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 344.0
TLS2_k127_3012748_7 Dihydroxyacetone kinase K05879 - 2.7.1.121 0.000000000000000000000000000000000000000000000000000000000001757 220.0
TLS2_k127_3012748_8 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000000000000001303 173.0
TLS2_k127_3012748_9 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.000000000000000000000000000000000000000000006376 168.0
TLS2_k127_3031915_0 Glutamate decarboxylase and related PLP-dependent K01580 - 4.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 491.0
TLS2_k127_3031915_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000001508 173.0
TLS2_k127_3031915_2 YCII-related domain - - - 0.0000000000000000000000000000000000000000002882 169.0
TLS2_k127_3031915_3 metalloendopeptidase activity K03799 - - 0.000000003497 69.0
TLS2_k127_3031915_4 PGAP1-like protein K01046 GO:0003674,GO:0003824,GO:0004806,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0019433,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046461,GO:0046464,GO:0046486,GO:0046503,GO:0052689,GO:0071704,GO:1901575 3.1.1.3 0.0001592 55.0
TLS2_k127_3067947_0 Zn_pept - - - 5.854e-273 867.0
TLS2_k127_3067947_1 Zn_pept - - - 4.413e-264 842.0
TLS2_k127_3067947_10 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000086 213.0
TLS2_k127_3067947_11 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000006801 208.0
TLS2_k127_3067947_12 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000001614 173.0
TLS2_k127_3067947_13 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000001178 143.0
TLS2_k127_3067947_14 Helix-turn-helix domain K07729 - - 0.0000000000000000000001682 101.0
TLS2_k127_3067947_15 - K01992 - - 0.000000000000001486 87.0
TLS2_k127_3067947_17 - - - - 0.00004313 48.0
TLS2_k127_3067947_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 518.0
TLS2_k127_3067947_3 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 509.0
TLS2_k127_3067947_4 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 482.0
TLS2_k127_3067947_5 Methyl-accepting Chemotaxis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 297.0
TLS2_k127_3067947_6 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003402 301.0
TLS2_k127_3067947_7 DNA synthesis involved in DNA repair - - - 0.000000000000000000000000000000000000000000000000000000000000000004474 232.0
TLS2_k127_3067947_8 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000128 235.0
TLS2_k127_3067947_9 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000001684 230.0
TLS2_k127_3139478_0 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 8.915e-283 884.0
TLS2_k127_3139478_1 PFAM carbohydrate kinase K00854 - 2.7.1.17 1.4e-206 653.0
TLS2_k127_3139478_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006655 371.0
TLS2_k127_3139478_11 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 331.0
TLS2_k127_3139478_12 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 317.0
TLS2_k127_3139478_13 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 296.0
TLS2_k127_3139478_14 COGs COG1318 transcriptional regulator protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006671 264.0
TLS2_k127_3139478_15 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002099 264.0
TLS2_k127_3139478_16 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003794 229.0
TLS2_k127_3139478_17 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000000000000000000007823 234.0
TLS2_k127_3139478_18 Serine phosphatase RsbU, regulator of sigma subunit - - - 0.0000000000000000000000000000000000000000000001659 181.0
TLS2_k127_3139478_19 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000004523 169.0
TLS2_k127_3139478_2 Periplasmic binding protein K01999 - - 5e-204 649.0
TLS2_k127_3139478_20 Domain of unknown function (DUF4157) - - - 0.000000000000000000000000000000000000000001694 165.0
TLS2_k127_3139478_21 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000003017 168.0
TLS2_k127_3139478_22 Histidine kinase - - - 0.0000000000000000000000000000000000000009353 167.0
TLS2_k127_3139478_23 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000000000000003502 127.0
TLS2_k127_3139478_24 Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000005556 123.0
TLS2_k127_3139478_25 NAD(P)H-binding K18981 - 1.1.1.203 0.0000000000000000002632 102.0
TLS2_k127_3139478_26 Cell Wall K01448 - 3.5.1.28 0.0000000000000003275 91.0
TLS2_k127_3139478_27 YjbR - - - 0.0000000002948 64.0
TLS2_k127_3139478_3 LVIVD repeat - - - 7.272e-194 623.0
TLS2_k127_3139478_4 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 590.0
TLS2_k127_3139478_5 Belongs to the xylose isomerase family K01805 - 5.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 582.0
TLS2_k127_3139478_6 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 547.0
TLS2_k127_3139478_7 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 480.0
TLS2_k127_3139478_8 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 417.0
TLS2_k127_3139478_9 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 404.0
TLS2_k127_3139799_0 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.0000000000000000000000000005946 119.0
TLS2_k127_3139799_1 - - - - 0.00000000000000000008768 100.0
TLS2_k127_3139799_2 - - - - 0.0000000002561 66.0
TLS2_k127_3139799_3 - - - - 0.000000005023 65.0
TLS2_k127_3231339_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1081.0
TLS2_k127_3231339_1 Aldehyde dehydrogenase family K00128 - 1.2.1.3 1.508e-195 623.0
TLS2_k127_3231339_10 Selenocysteine-specific translation elongation factor K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 369.0
TLS2_k127_3231339_11 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 349.0
TLS2_k127_3231339_12 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 345.0
TLS2_k127_3231339_13 Protein of unknown function (DUF445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 331.0
TLS2_k127_3231339_14 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 324.0
TLS2_k127_3231339_15 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000001649 267.0
TLS2_k127_3231339_16 PHP domain protein K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000000003337 233.0
TLS2_k127_3231339_17 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000009092 202.0
TLS2_k127_3231339_18 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000002045 196.0
TLS2_k127_3231339_19 Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000006026 186.0
TLS2_k127_3231339_2 Pkd domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 612.0
TLS2_k127_3231339_20 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02080,K02564 - 3.5.99.6 0.00000000000000000000000000000000000000000000001967 182.0
TLS2_k127_3231339_21 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.00000000000000000000000000000000000000000007392 172.0
TLS2_k127_3231339_22 PFAM short-chain dehydrogenase reductase SDR K03793 - 1.5.1.33 0.00000000000000000000000000000000000000001764 162.0
TLS2_k127_3231339_23 YjbR - - - 0.00000000000000000000000000000000000001951 148.0
TLS2_k127_3231339_24 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000001083 149.0
TLS2_k127_3231339_25 heme binding K21471,K21472 - - 0.000000000000000000000000000000000002259 154.0
TLS2_k127_3231339_26 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000005839 142.0
TLS2_k127_3231339_27 translation initiation inhibitor, yjgF family K09022 GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019239,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046360,GO:0046361,GO:0046394,GO:0046459,GO:0051790,GO:0071704,GO:0072330,GO:1901576 3.5.99.10 0.00000000000000000000000000000009126 133.0
TLS2_k127_3231339_28 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K07589 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564 1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8 0.000000000000000000000000000002555 124.0
TLS2_k127_3231339_29 Iron-sulphur cluster biosynthesis K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.000000000000000000000000000004726 125.0
TLS2_k127_3231339_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 583.0
TLS2_k127_3231339_30 NUDIX domain - - - 0.00000000000000000000000000001374 128.0
TLS2_k127_3231339_31 Phosphotriesterase family K07048 - - 0.0000000000000000000000000002461 117.0
TLS2_k127_3231339_32 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000000000000009068 103.0
TLS2_k127_3231339_33 Protein affecting phage T7 exclusion by the F plasmid K07113 - - 0.00000000000000000000397 104.0
TLS2_k127_3231339_34 - - - - 0.0000000000000003426 87.0
TLS2_k127_3231339_35 Stress responsive A/B Barrel Domain - - - 0.000000000000001063 85.0
TLS2_k127_3231339_36 Scaffold protein Nfu/NifU N terminal - - - 0.000000000001018 71.0
TLS2_k127_3231339_37 phosphorelay signal transduction system - - - 0.000000000005863 74.0
TLS2_k127_3231339_39 Haemolysin-type calcium binding protein related domain K01406 - 3.4.24.40 0.000005398 56.0
TLS2_k127_3231339_4 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 549.0
TLS2_k127_3231339_40 Condensation domain - - - 0.000154 53.0
TLS2_k127_3231339_42 NfeD-like C-terminal, partner-binding K07403 - - 0.0003851 53.0
TLS2_k127_3231339_5 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 541.0
TLS2_k127_3231339_6 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 543.0
TLS2_k127_3231339_7 Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 496.0
TLS2_k127_3231339_8 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 464.0
TLS2_k127_3231339_9 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 466.0
TLS2_k127_3270520_0 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006375 449.0
TLS2_k127_3270520_1 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 411.0
TLS2_k127_3270520_2 amino acid transport K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 364.0
TLS2_k127_3270520_3 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 311.0
TLS2_k127_3270520_4 protein containing SIS (Sugar isomerase) phosphosugar binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 302.0
TLS2_k127_3270520_5 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000002388 243.0
TLS2_k127_3270520_6 regulatory protein GntR HTH K03710 - - 0.0000000000000000000000000000000000000000000000000000000004955 210.0
TLS2_k127_3270520_7 Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000001985 214.0
TLS2_k127_3270615_0 ABC transporter - - - 0.0 1437.0
TLS2_k127_3270615_1 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 430.0
TLS2_k127_3270615_10 Glucose-regulated metallo-peptidase M90 K09933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001493 254.0
TLS2_k127_3270615_11 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002047 248.0
TLS2_k127_3270615_12 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding - - - 0.000000000000000000000000000000000000000000000000000000000000004899 228.0
TLS2_k127_3270615_13 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000001351 229.0
TLS2_k127_3270615_14 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000001484 210.0
TLS2_k127_3270615_15 - - - - 0.000000000000000000000000000000000000000000000000000002099 201.0
TLS2_k127_3270615_16 methyltransferase K13311,K13326,K21335 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0046983 2.1.1.234 0.000000000000000000000000000000000000000000000000000006045 204.0
TLS2_k127_3270615_17 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.00000000000000000000000000000000000000000000000000005307 200.0
TLS2_k127_3270615_18 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000003992 188.0
TLS2_k127_3270615_19 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000001287 190.0
TLS2_k127_3270615_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 334.0
TLS2_k127_3270615_20 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000001512 176.0
TLS2_k127_3270615_21 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000001024 170.0
TLS2_k127_3270615_22 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000003583 164.0
TLS2_k127_3270615_23 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000001609 153.0
TLS2_k127_3270615_24 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000003036 154.0
TLS2_k127_3270615_25 Histidine kinase - - - 0.0000000000000000000000000000001001 132.0
TLS2_k127_3270615_26 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000001773 126.0
TLS2_k127_3270615_27 - - - - 0.00000000000000000000001213 103.0
TLS2_k127_3270615_28 N-terminal Region. This family is found at the N-terminus of a number of subtilisins. It is cleaved prior to activation of the enzyme - - - 0.00000000000000000003651 101.0
TLS2_k127_3270615_29 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000002117 69.0
TLS2_k127_3270615_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 313.0
TLS2_k127_3270615_30 - - - - 0.0004013 49.0
TLS2_k127_3270615_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008049 311.0
TLS2_k127_3270615_5 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 302.0
TLS2_k127_3270615_6 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 291.0
TLS2_k127_3270615_7 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001211 280.0
TLS2_k127_3270615_8 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001808 265.0
TLS2_k127_3270615_9 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001094 260.0
TLS2_k127_335630_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 592.0
TLS2_k127_335630_1 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 444.0
TLS2_k127_335630_10 RDD family - - - 0.000000000000000000000003377 110.0
TLS2_k127_335630_11 Transcriptional regulator - - - 0.00000000000000000000003431 104.0
TLS2_k127_335630_12 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000007387 94.0
TLS2_k127_335630_13 RDD family - - - 0.000000000000000001353 97.0
TLS2_k127_335630_14 PFAM blue (type 1) copper domain protein - - - 0.00005667 50.0
TLS2_k127_335630_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005463 411.0
TLS2_k127_335630_3 ERCC4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 321.0
TLS2_k127_335630_4 -O-antigen K02847 - - 0.0000000000000000000000000000000000000000000000000000000000000009287 244.0
TLS2_k127_335630_5 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000001803 218.0
TLS2_k127_335630_6 oxidoreductase - - - 0.0000000000000000000000000000000000000000008296 169.0
TLS2_k127_335630_7 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000001074 153.0
TLS2_k127_335630_8 Haem-binding domain - - - 0.0000000000000000000000000000005324 130.0
TLS2_k127_335630_9 Ceramidase - - - 0.000000000000000000000000003637 123.0
TLS2_k127_3362005_0 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 356.0
TLS2_k127_3362005_1 Belongs to the bacterial solute-binding protein 3 family K02030 - - 0.000000000000000000000000000000000000000000006394 174.0
TLS2_k127_3362450_0 TadE-like protein - - - 0.00000002292 62.0
TLS2_k127_3362450_1 Putative Flp pilus-assembly TadE/G-like - - - 0.00009335 54.0
TLS2_k127_3362450_2 TadE-like protein - - - 0.0001133 51.0
TLS2_k127_338007_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1145.0
TLS2_k127_338007_1 Starch binding domain K00705 - 2.4.1.25 7.274e-203 661.0
TLS2_k127_338007_10 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 507.0
TLS2_k127_338007_11 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 491.0
TLS2_k127_338007_12 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 432.0
TLS2_k127_338007_13 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 415.0
TLS2_k127_338007_14 FAD dependent oxidoreductase K00109 - 1.1.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 412.0
TLS2_k127_338007_15 peptidase U62, modulator of DNA gyrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 365.0
TLS2_k127_338007_16 ATPases associated with a variety of cellular activities K02028,K02029 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 350.0
TLS2_k127_338007_17 Short-chain alcohol dehydrogenase K16066 - 1.1.1.381 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 342.0
TLS2_k127_338007_18 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 306.0
TLS2_k127_338007_19 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 291.0
TLS2_k127_338007_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.071e-200 641.0
TLS2_k127_338007_20 ABC transporter (Permease) K02029,K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001209 287.0
TLS2_k127_338007_21 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003158 294.0
TLS2_k127_338007_22 signal transduction histidine kinase K07653 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004941 296.0
TLS2_k127_338007_23 Transcriptional regulatory protein, C terminal K07669,K07672 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004209 285.0
TLS2_k127_338007_24 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005922 276.0
TLS2_k127_338007_25 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000007293 244.0
TLS2_k127_338007_26 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000002655 229.0
TLS2_k127_338007_27 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000006897 227.0
TLS2_k127_338007_28 cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000505 223.0
TLS2_k127_338007_29 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000000001074 190.0
TLS2_k127_338007_3 Cytochrome c-type biogenesis protein CcmF K02198 - - 1.647e-199 642.0
TLS2_k127_338007_30 Belongs to the thioredoxin family K00384,K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.9 0.000000000000000000000000000000000000000000000000001607 187.0
TLS2_k127_338007_31 CcmB protein K02194 - - 0.00000000000000000000000000000000000000000000000007906 187.0
TLS2_k127_338007_32 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000003986 179.0
TLS2_k127_338007_33 Thiol-disulfide isomerase-like thioredoxin K02199 - - 0.00000000000000000000000000000000000000000000004511 190.0
TLS2_k127_338007_34 Putative peptidoglycan binding domain - - - 0.00000000000000000000000000000000000000000006315 181.0
TLS2_k127_338007_35 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000261 167.0
TLS2_k127_338007_36 PFAM NUDIX domain - - - 0.0000000000000000000000000000000000000002271 156.0
TLS2_k127_338007_37 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000005231 156.0
TLS2_k127_338007_38 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000001162 115.0
TLS2_k127_338007_39 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000003275 106.0
TLS2_k127_338007_4 Highly conserved protein containing a thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 617.0
TLS2_k127_338007_40 Alpha/beta hydrolase - - - 0.000000000000000000001846 109.0
TLS2_k127_338007_41 subunit of a heme lyase K02200 - - 0.0000000000000000003279 94.0
TLS2_k127_338007_42 - - - - 0.00000000000000000329 93.0
TLS2_k127_338007_43 Anti-sigma-K factor rskA - GO:0000988,GO:0000989,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006417,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010608,GO:0016020,GO:0016989,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - 0.0000000001223 71.0
TLS2_k127_338007_44 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000464 52.0
TLS2_k127_338007_5 Peptidase family M13 K07386 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 603.0
TLS2_k127_338007_6 peptidase U62, modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 584.0
TLS2_k127_338007_7 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 582.0
TLS2_k127_338007_8 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 555.0
TLS2_k127_338007_9 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 514.0
TLS2_k127_3394082_0 DEAD/H associated K03724 - - 0.0 1430.0
TLS2_k127_3394082_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812,K08351 - 1.7.2.3 4.933e-296 928.0
TLS2_k127_3394082_10 PFAM Transketolase central region K00162,K00167 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003664 392.0
TLS2_k127_3394082_11 Fructosamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 383.0
TLS2_k127_3394082_12 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K14441 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005685 370.0
TLS2_k127_3394082_13 Belongs to the CinA family K03742,K03743 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 334.0
TLS2_k127_3394082_14 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 327.0
TLS2_k127_3394082_15 Histidinol phosphate phosphatase, HisJ K04486 - 3.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 313.0
TLS2_k127_3394082_16 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002483 286.0
TLS2_k127_3394082_17 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000006045 265.0
TLS2_k127_3394082_18 photosystem I assembly BtpA K06971 - - 0.0000000000000000000000000000000000000000000000000000000000000002046 229.0
TLS2_k127_3394082_19 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.000000000000000000000000000000000000000000000000000000000000001306 224.0
TLS2_k127_3394082_2 Class II release factor RF3, C-terminal domain K02837 - - 1.078e-195 625.0
TLS2_k127_3394082_20 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000001556 230.0
TLS2_k127_3394082_21 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000001859 219.0
TLS2_k127_3394082_22 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000005412 230.0
TLS2_k127_3394082_23 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.0000000000000000000000000000000000000000000000000000000000007775 225.0
TLS2_k127_3394082_24 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000000000000000000000000000000001071 207.0
TLS2_k127_3394082_25 belongs to the thioredoxin family K03671,K05838 - - 0.000000000000000000000000000000000000000000000000000006149 209.0
TLS2_k127_3394082_26 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000008256 185.0
TLS2_k127_3394082_27 survival protein SurE K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000415 183.0
TLS2_k127_3394082_28 hydroperoxide reductase activity - - - 0.0000000000000000000000000000000000000000000004474 173.0
TLS2_k127_3394082_29 DinB superfamily - - - 0.0000000000000000000000000000000000000000004686 167.0
TLS2_k127_3394082_3 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 562.0
TLS2_k127_3394082_30 Von Willebrand factor type D domain - - - 0.00000000000000000000000000000000000000002699 177.0
TLS2_k127_3394082_31 flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000007911 141.0
TLS2_k127_3394082_32 RF-1 domain K15034 - - 0.00000000000000000000000000008736 120.0
TLS2_k127_3394082_33 isomerase activity K01821 - 5.3.2.6 0.00000000000000000000000005671 112.0
TLS2_k127_3394082_35 META domain K03668 - - 0.00000000000000000000004658 104.0
TLS2_k127_3394082_36 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000001021 93.0
TLS2_k127_3394082_37 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.000000000000008802 83.0
TLS2_k127_3394082_4 PFAM chorismate K01665,K03342 - 2.6.1.85,4.1.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 557.0
TLS2_k127_3394082_40 ATPase associated with various cellular activities AAA_5 K04748 - - 0.0000002148 63.0
TLS2_k127_3394082_5 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 537.0
TLS2_k127_3394082_6 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 471.0
TLS2_k127_3394082_7 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 477.0
TLS2_k127_3394082_8 Insulinase (Peptidase family M16) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 398.0
TLS2_k127_3394082_9 COG3209 Rhs family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 401.0
TLS2_k127_3397973_0 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 432.0
TLS2_k127_3397973_1 Membrane protein involved in D-alanine export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 405.0
TLS2_k127_3397973_10 - - - - 0.000007041 56.0
TLS2_k127_3397973_2 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 348.0
TLS2_k127_3397973_3 DNA polymerase LigD, polymerase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000008375 283.0
TLS2_k127_3397973_4 PFAM Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000000000000000000000000000000000000000004996 226.0
TLS2_k127_3397973_5 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.0000000000000000000000000000000000000369 159.0
TLS2_k127_3397973_6 Cupin 2, conserved barrel domain protein K00452 GO:0000334,GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0044237,GO:0044248,GO:0051213,GO:0055114 1.13.11.6 0.00000000000000000000000000005888 126.0
TLS2_k127_3397973_8 DsrE/DsrF-like family K06039 - - 0.00000004521 61.0
TLS2_k127_3397973_9 Rhodanese Homology Domain - - - 0.0000002099 53.0
TLS2_k127_3402498_0 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 370.0
TLS2_k127_3402498_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 364.0
TLS2_k127_3402498_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 360.0
TLS2_k127_3450198_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 447.0
TLS2_k127_3450198_1 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 404.0
TLS2_k127_3450198_2 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 355.0
TLS2_k127_3450198_3 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 362.0
TLS2_k127_3450198_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 343.0
TLS2_k127_3450198_5 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 340.0
TLS2_k127_3450198_6 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000004751 132.0
TLS2_k127_3450198_7 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000005413 119.0
TLS2_k127_3450198_8 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000002302 113.0
TLS2_k127_3450198_9 DJ-1/PfpI family - - - 0.00000000000000000001532 98.0
TLS2_k127_3483931_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 546.0
TLS2_k127_3483931_1 PFAM Alpha amylase, catalytic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007353 521.0
TLS2_k127_3483931_11 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000004557 193.0
TLS2_k127_3483931_12 DNA segregation ATPase FtsK SpoIIIE and related K03466 - - 0.000000000000000000000000000000000000001726 165.0
TLS2_k127_3483931_13 - - - - 0.000118 53.0
TLS2_k127_3483931_2 ATPases associated with a variety of cellular activities K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 452.0
TLS2_k127_3483931_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 409.0
TLS2_k127_3483931_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 351.0
TLS2_k127_3483931_5 SpoU rRNA Methylase family K00556 - 2.1.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 314.0
TLS2_k127_3483931_6 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007532 278.0
TLS2_k127_3483931_7 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006707 265.0
TLS2_k127_3483931_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005202 258.0
TLS2_k127_3483931_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000005993 248.0
TLS2_k127_3493351_0 Hemerythrin HHE cation binding domain K01534 - 3.6.3.3,3.6.3.5 1.991e-221 711.0
TLS2_k127_3493351_1 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 321.0
TLS2_k127_3493351_2 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000003341 220.0
TLS2_k127_3493351_3 Bacterial regulatory proteins, tetR family - - - 0.000000000000002774 79.0
TLS2_k127_3533732_0 Protein of unknown function (DUF2089) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003034 232.0
TLS2_k127_3533732_1 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000083 216.0
TLS2_k127_3533732_2 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000001852 86.0
TLS2_k127_3533732_3 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00001511 54.0
TLS2_k127_3533732_4 DNA-templated transcription, initiation - - - 0.0008481 45.0
TLS2_k127_3536171_0 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 319.0
TLS2_k127_3536171_1 overlaps another CDS with the same product name - - - 0.0000000000002127 72.0
TLS2_k127_3538638_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1356.0
TLS2_k127_3538638_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0 1090.0
TLS2_k127_3538638_10 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007783 544.0
TLS2_k127_3538638_11 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 489.0
TLS2_k127_3538638_12 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II K01835,K01840 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 499.0
TLS2_k127_3538638_13 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 421.0
TLS2_k127_3538638_14 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 402.0
TLS2_k127_3538638_15 Protein of unknown function (DUF433) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 285.0
TLS2_k127_3538638_16 phosphoenolpyruvate carboxykinase (ATP) activity K01610 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 4.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003249 293.0
TLS2_k127_3538638_17 Predicted membrane protein (DUF2254) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009405,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704 - 0.0000000000000000000000000000000000000000000000000000000000000000000002863 254.0
TLS2_k127_3538638_18 Domain of unknown function (DUF427) - - - 0.00000000000000000000000000000000000000000000000000000000000000004306 229.0
TLS2_k127_3538638_19 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000007335 204.0
TLS2_k127_3538638_2 Fungalysin metallopeptidase (M36) - - - 0.0 1041.0
TLS2_k127_3538638_20 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000005318 154.0
TLS2_k127_3538638_21 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.000000000000000000000000000000000000004977 160.0
TLS2_k127_3538638_22 - - - - 0.0000000000000000000000000000000000413 139.0
TLS2_k127_3538638_23 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000002926 121.0
TLS2_k127_3538638_24 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000002568 124.0
TLS2_k127_3538638_25 Antibiotic biosynthesis monooxygenase K21481 - 1.14.99.57 0.000000000000000000000000001373 119.0
TLS2_k127_3538638_26 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000002712 119.0
TLS2_k127_3538638_27 transcriptional regulator - - - 0.000000000000000000000000007883 118.0
TLS2_k127_3538638_28 Glycosyl hydrolases family 25 - - - 0.00000000000000000002178 107.0
TLS2_k127_3538638_29 Domain of unknown function (DUF4395) - - - 0.00000000000000000005728 96.0
TLS2_k127_3538638_3 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 5.775e-282 880.0
TLS2_k127_3538638_30 cell redox homeostasis K02199,K03671,K03672 - 1.8.1.8 0.00005727 54.0
TLS2_k127_3538638_31 WD40-like Beta Propeller Repeat - GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - 0.0001523 54.0
TLS2_k127_3538638_32 Cys/Met metabolism PLP-dependent enzyme - - - 0.0006651 42.0
TLS2_k127_3538638_4 Belongs to the sulfate adenylyltransferase family K00390,K00860,K00958,K13811 GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564 1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4 7.632e-252 789.0
TLS2_k127_3538638_5 Pyruvate phosphate dikinase, PEP K01006,K01007 - 2.7.9.1,2.7.9.2 8.554e-216 697.0
TLS2_k127_3538638_6 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K01281 - 3.4.14.11 2.622e-213 680.0
TLS2_k127_3538638_7 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 1.861e-197 638.0
TLS2_k127_3538638_8 LVIVD repeat - - - 4.872e-196 629.0
TLS2_k127_3538638_9 PFAM deoxyribose-phosphate aldolase phospho-2- dehydro-3-deoxyheptonate aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006552 562.0
TLS2_k127_356757_0 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 347.0
TLS2_k127_356757_1 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002852 267.0
TLS2_k127_356757_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000005871 231.0
TLS2_k127_356757_3 Peptidase family M23 - - - 0.0000000000000000000000000000000001061 151.0
TLS2_k127_356757_4 Transport permease protein K01992 - - 0.00000000000002253 74.0
TLS2_k127_3577631_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 498.0
TLS2_k127_3577631_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 452.0
TLS2_k127_3577631_2 PhoD-like phosphatase K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 456.0
TLS2_k127_3577631_3 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000125 148.0
TLS2_k127_3577631_4 PFAM Integrase catalytic K07497 - - 0.000000000000000000000000000000005567 130.0
TLS2_k127_3577631_5 Integrase core domain K07497 - - 0.000000000000000162 81.0
TLS2_k127_3579337_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 533.0
TLS2_k127_3579337_1 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 479.0
TLS2_k127_3579337_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000003278 214.0
TLS2_k127_3579337_3 Subtilase family - - - 0.0000000000000000000000000000000000000000008014 177.0
TLS2_k127_3615889_0 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000000000000000000000006876 202.0
TLS2_k127_3615889_1 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000000000004247 177.0
TLS2_k127_3642074_0 Aminotransferase class-V - - - 1.614e-235 740.0
TLS2_k127_3642074_1 luxR family - - - 1.348e-228 738.0
TLS2_k127_3642074_10 Metal binding domain of Ada K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000002388 211.0
TLS2_k127_3642074_11 Methyltransferase small domain K00598 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0051704 2.1.1.144 0.000000000000000000000000000000000000000000000000000001664 211.0
TLS2_k127_3642074_12 domain, Protein K01114,K12287,K15125,K16191,K20276 - 3.1.4.3 0.000000000000000000000000000000000000000000000000000002624 205.0
TLS2_k127_3642074_13 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000007929 192.0
TLS2_k127_3642074_14 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000005056 130.0
TLS2_k127_3642074_15 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000006324 132.0
TLS2_k127_3642074_16 Peptidyl-prolyl cis-trans isomerase K01802,K03774,K03775 - 5.2.1.8 0.000000000000000000000000000005443 135.0
TLS2_k127_3642074_17 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.000000000000000000000000003513 117.0
TLS2_k127_3642074_18 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000001909 114.0
TLS2_k127_3642074_19 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. K19519 - - 0.00000000000000000000008316 107.0
TLS2_k127_3642074_2 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 527.0
TLS2_k127_3642074_3 helicase superfamily c-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 464.0
TLS2_k127_3642074_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 401.0
TLS2_k127_3642074_5 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 360.0
TLS2_k127_3642074_6 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 321.0
TLS2_k127_3642074_7 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007921 274.0
TLS2_k127_3642074_8 Uncharacterized protein conserved in bacteria (DUF2332) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007286 271.0
TLS2_k127_3642074_9 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003233 255.0
TLS2_k127_3644698_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 9.546e-276 868.0
TLS2_k127_3644698_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 325.0
TLS2_k127_3649879_0 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001605 264.0
TLS2_k127_3649879_1 MafB19-like deaminase K01485,K11991 - 3.5.4.1,3.5.4.33 0.0000000000000000000000000000000000000000000000006521 179.0
TLS2_k127_3649879_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000006662 170.0
TLS2_k127_3649879_3 - - - - 0.00000000000000000000211 106.0
TLS2_k127_3649879_4 Peptidoglycan-recognition protein SC2-like K01446 GO:0000270,GO:0001775,GO:0001817,GO:0001818,GO:0001906,GO:0002218,GO:0002221,GO:0002225,GO:0002237,GO:0002252,GO:0002253,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002682,GO:0002683,GO:0002684,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002699,GO:0002700,GO:0002702,GO:0002757,GO:0002758,GO:0002759,GO:0002760,GO:0002764,GO:0002784,GO:0002786,GO:0002803,GO:0002805,GO:0002807,GO:0002808,GO:0002816,GO:0002831,GO:0002833,GO:0002920,GO:0002922,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006810,GO:0006887,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006963,GO:0006965,GO:0007154,GO:0007165,GO:0007166,GO:0008063,GO:0008144,GO:0008150,GO:0008152,GO:0008329,GO:0008592,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009595,GO:0009605,GO:0009607,GO:0009617,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0012505,GO:0016019,GO:0016045,GO:0016192,GO:0016787,GO:0016810,GO:0016811,GO:0019222,GO:0019730,GO:0023051,GO:0023052,GO:0023056,GO:0030139,GO:0030141,GO:0030203,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031341,GO:0031343,GO:0031347,GO:0031348,GO:0031349,GO:0031410,GO:0031640,GO:0031974,GO:0031982,GO:0031983,GO:0032101,GO:0032102,GO:0032103,GO:0032494,GO:0032500,GO:0032649,GO:0032689,GO:0032814,GO:0032815,GO:0032823,GO:0032824,GO:0032826,GO:0032827,GO:0032940,GO:0033218,GO:0034248,GO:0034250,GO:0034774,GO:0035580,GO:0035821,GO:0036230,GO:0038023,GO:0038187,GO:0040007,GO:0042119,GO:0042221,GO:0042268,GO:0042277,GO:0042581,GO:0042742,GO:0042749,GO:0042752,GO:0042834,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0043299,GO:0043312,GO:0043900,GO:0043902,GO:0044110,GO:0044116,GO:0044117,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045087,GO:0045088,GO:0045089,GO:0045187,GO:0045321,GO:0045335,GO:0045595,GO:0045596,GO:0045619,GO:0045620,GO:0045752,GO:0045824,GO:0045919,GO:0046903,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050727,GO:0050728,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050830,GO:0050865,GO:0050866,GO:0050896,GO:0051093,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051239,GO:0051241,GO:0051249,GO:0051250,GO:0051606,GO:0051704,GO:0051707,GO:0051709,GO:0051710,GO:0051712,GO:0051714,GO:0051716,GO:0060089,GO:0060205,GO:0061783,GO:0061844,GO:0065007,GO:0070013,GO:0070820,GO:0071682,GO:0071704,GO:0080134,GO:0097013,GO:0097367,GO:0097708,GO:0098542,GO:0098543,GO:0098581,GO:0099503,GO:1900424,GO:1900426,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901700,GO:1902105,GO:1902106,GO:1903706,GO:1903707,GO:1904724,GO:2000026 - 0.00000000000000000007405 101.0
TLS2_k127_3649879_5 TIGRFAM spore coat assembly protein SafA - - - 0.000000000000000001442 97.0
TLS2_k127_3723752_0 Fungalysin metallopeptidase (M36) - - - 1.884e-316 992.0
TLS2_k127_3723752_1 Beta propeller domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005818 423.0
TLS2_k127_3723752_2 Redoxin - - - 0.00000000000000000000000000000000000001044 153.0
TLS2_k127_3723752_3 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000001078 102.0
TLS2_k127_3723752_4 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.0000000000000000401 86.0
TLS2_k127_374559_0 Glutamine amidotransferase domain K00820 - 2.6.1.16 1.181e-209 669.0
TLS2_k127_374559_1 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 422.0
TLS2_k127_374559_10 sugar phosphate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003575 289.0
TLS2_k127_374559_11 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001746 292.0
TLS2_k127_374559_12 Putative esterase K07214 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001565 272.0
TLS2_k127_374559_13 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000852 252.0
TLS2_k127_374559_14 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000003289 238.0
TLS2_k127_374559_15 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000004099 214.0
TLS2_k127_374559_16 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000003168 206.0
TLS2_k127_374559_17 PFAM peptidase S58 DmpA - - - 0.000000000000000000000000000000000000000000000000000001657 203.0
TLS2_k127_374559_18 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000001208 191.0
TLS2_k127_374559_19 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000005719 181.0
TLS2_k127_374559_2 Belongs to the D-alanine--D-alanine ligase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 398.0
TLS2_k127_374559_20 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000003003 175.0
TLS2_k127_374559_21 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000000000000003112 164.0
TLS2_k127_374559_22 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000004253 160.0
TLS2_k127_374559_23 SCO1 SenC K07152 - - 0.00000000000000000000000000000000000000001916 160.0
TLS2_k127_374559_24 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000004473 155.0
TLS2_k127_374559_25 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.0000000000000000000000000000000000000001995 165.0
TLS2_k127_374559_26 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000008148 143.0
TLS2_k127_374559_27 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06925 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000001795 146.0
TLS2_k127_374559_28 tRNA threonylcarbamoyladenosine modification K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.00000000000000000000000000000000001012 148.0
TLS2_k127_374559_29 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.0000000000000000000000000000000000816 145.0
TLS2_k127_374559_3 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 395.0
TLS2_k127_374559_30 Nudix hydrolase - - - 0.000000000000000000000000008287 118.0
TLS2_k127_374559_31 PFAM nucleic acid binding, OB-fold, tRNA - - - 0.0000000000000000000001247 102.0
TLS2_k127_374559_32 Cytochrome c K02275 - 1.9.3.1 0.00000000000000000001326 104.0
TLS2_k127_374559_33 Putative adhesin - - - 0.000000000000000000536 96.0
TLS2_k127_374559_34 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000005404 98.0
TLS2_k127_374559_35 PFAM blue (type 1) copper domain protein - - - 0.00000000000000002714 94.0
TLS2_k127_374559_36 protein conserved in bacteria K09796 - - 0.0000000000000004557 88.0
TLS2_k127_374559_37 extracellular matrix structural constituent - - - 0.000000000000001434 92.0
TLS2_k127_374559_38 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000001069 72.0
TLS2_k127_374559_39 LVIVD repeat - - - 0.00000009219 66.0
TLS2_k127_374559_4 PFAM glycoside hydrolase family 3 K05349 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007056 365.0
TLS2_k127_374559_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 364.0
TLS2_k127_374559_6 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 350.0
TLS2_k127_374559_7 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 345.0
TLS2_k127_374559_8 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 342.0
TLS2_k127_374559_9 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 293.0
TLS2_k127_3749528_0 Flavin containing amine oxidoreductase - - - 8.784e-255 794.0
TLS2_k127_3749528_1 ADP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007987 509.0
TLS2_k127_3749528_10 Domain of Unknown Function (DUF1599) - - - 0.00000000000000000000000001598 122.0
TLS2_k127_3749528_11 RES domain - - - 0.0000000000000004219 87.0
TLS2_k127_3749528_12 Evidence 4 Homologs of previously reported genes of - - - 0.000003728 54.0
TLS2_k127_3749528_13 Major facilitator superfamily - - - 0.0003034 50.0
TLS2_k127_3749528_2 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 466.0
TLS2_k127_3749528_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 416.0
TLS2_k127_3749528_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008015 418.0
TLS2_k127_3749528_5 Rieske 2Fe-2S K00479 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009068 414.0
TLS2_k127_3749528_6 peptidase activity K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009407 344.0
TLS2_k127_3749528_7 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 306.0
TLS2_k127_3749528_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 290.0
TLS2_k127_3749528_9 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006284 282.0
TLS2_k127_3767893_0 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K10441 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008312 556.0
TLS2_k127_3767893_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 538.0
TLS2_k127_3767893_2 AP endonuclease family 2 C terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009398 452.0
TLS2_k127_3767893_3 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 451.0
TLS2_k127_3767893_4 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 383.0
TLS2_k127_3767893_5 Belongs to the binding-protein-dependent transport system permease family K02057,K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 350.0
TLS2_k127_3767893_6 Phosphotriesterase family K07048 - - 0.000000000000000000000000000000000000000000000000000007448 200.0
TLS2_k127_3782519_0 Predicted membrane protein (DUF2254) - - - 0.00000000000000000000000000000000000000000000000000000000000000004788 237.0
TLS2_k127_38253_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 1.517e-286 924.0
TLS2_k127_38253_1 Flavin containing amine oxidoreductase - - - 3.136e-237 756.0
TLS2_k127_38253_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 322.0
TLS2_k127_38253_11 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 302.0
TLS2_k127_38253_12 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004361 296.0
TLS2_k127_38253_13 Glutamine cyclotransferase K00683 - 2.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000009383 271.0
TLS2_k127_38253_14 ABC transporter K02049,K10831,K15555 - 3.6.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000005833 275.0
TLS2_k127_38253_15 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000008456 237.0
TLS2_k127_38253_16 Uncharacterized conserved protein (DUF2278) - - - 0.0000000000000000000000000000000000000000000000000000000000000001057 229.0
TLS2_k127_38253_17 Multicopper oxidase K08100 - 1.3.3.5 0.000000000000000000000000000000000000000000000000000000006221 200.0
TLS2_k127_38253_18 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000001119 197.0
TLS2_k127_38253_19 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000006088 173.0
TLS2_k127_38253_2 Aminotransferase class-III K00596 - 4.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009747 611.0
TLS2_k127_38253_20 transferase activity, transferring acyl groups K15520 - 2.3.1.189 0.00000000000000000000000000000000000007731 147.0
TLS2_k127_38253_21 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000001304 150.0
TLS2_k127_38253_22 Histidine kinase - - - 0.00000000000000000000000000000000008518 148.0
TLS2_k127_38253_23 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000002955 123.0
TLS2_k127_38253_24 Transcriptional regulator - - - 0.000000000000000000000003955 109.0
TLS2_k127_38253_26 2TM domain - - - 0.00000000000000881 77.0
TLS2_k127_38253_27 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.0000000000004076 77.0
TLS2_k127_38253_28 Alpha-lytic protease prodomain - - - 0.000000000004766 76.0
TLS2_k127_38253_3 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005246 608.0
TLS2_k127_38253_30 - - - - 0.0001181 52.0
TLS2_k127_38253_31 protein import K01179 - 3.2.1.4 0.0001696 54.0
TLS2_k127_38253_4 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 592.0
TLS2_k127_38253_5 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K01281 - 3.4.14.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 578.0
TLS2_k127_38253_6 Belongs to the FPP GGPP synthase family K13787,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 385.0
TLS2_k127_38253_7 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 367.0
TLS2_k127_38253_9 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 325.0
TLS2_k127_3861133_0 AAA domain, putative AbiEii toxin, Type IV TA system K16786,K16787 - - 6.169e-219 691.0
TLS2_k127_3861133_1 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 572.0
TLS2_k127_3861133_10 NADPH quinone reductase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 340.0
TLS2_k127_3861133_11 Belongs to the SEDS family K03588 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004879 322.0
TLS2_k127_3861133_12 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001006 278.0
TLS2_k127_3861133_13 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008932 272.0
TLS2_k127_3861133_14 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000005475 252.0
TLS2_k127_3861133_15 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000436 260.0
TLS2_k127_3861133_16 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000008842 226.0
TLS2_k127_3861133_17 endonuclease III K03575 - - 0.00000000000000000000000000000000000000000000000000000000004812 224.0
TLS2_k127_3861133_18 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000007127 185.0
TLS2_k127_3861133_19 Phosphatase K20074 GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 3.1.3.16 0.0000000000000000000000000000000000000000000004532 181.0
TLS2_k127_3861133_2 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008486 465.0
TLS2_k127_3861133_20 PFAM Prenyltransferase squalene oxidase - - - 0.0000000000000000000000000000000000000001571 166.0
TLS2_k127_3861133_21 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000000000000003556 144.0
TLS2_k127_3861133_22 Peptidase family M23 - - - 0.000000000000000000000000000000001598 145.0
TLS2_k127_3861133_23 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000003806 117.0
TLS2_k127_3861133_24 Metallo-peptidase family M12 - - - 0.000000000000000002904 99.0
TLS2_k127_3861133_25 Prenyltransferase and squalene oxidase repeat - - - 0.000000000000000008974 97.0
TLS2_k127_3861133_26 Protein of unknown function (DUF2662) - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000000001968 92.0
TLS2_k127_3861133_27 Protein of unknown function (DUF4446) - - - 0.0000000000000004115 85.0
TLS2_k127_3861133_28 Forkhead associated domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.000000000000008286 87.0
TLS2_k127_3861133_29 - - - - 0.00000000522 61.0
TLS2_k127_3861133_3 beta-1,4-mannooligosaccharide phosphorylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 449.0
TLS2_k127_3861133_4 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 435.0
TLS2_k127_3861133_5 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 438.0
TLS2_k127_3861133_6 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 419.0
TLS2_k127_3861133_7 Cobalt transport protein K16785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 394.0
TLS2_k127_3861133_8 Penicillin binding protein transpeptidase domain K05364 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007103 360.0
TLS2_k127_3861133_9 ABC transporter (Permease) K16927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 343.0
TLS2_k127_3865610_0 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008288 618.0
TLS2_k127_3865610_1 enterobactin catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 494.0
TLS2_k127_3865610_10 PFAM Alcohol dehydrogenase GroES-like - - - 0.00000000000000000005519 91.0
TLS2_k127_3865610_11 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000002195 77.0
TLS2_k127_3865610_12 - - - - 0.0000000009606 70.0
TLS2_k127_3865610_13 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0001855 52.0
TLS2_k127_3865610_14 - - - - 0.0003196 46.0
TLS2_k127_3865610_2 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004964 271.0
TLS2_k127_3865610_3 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000000000001791 224.0
TLS2_k127_3865610_4 - - - - 0.0000000000000000000000000000000000000000000000000004338 192.0
TLS2_k127_3865610_5 alpha beta K06889 - - 0.000000000000000000000000000000000000000000000000005257 204.0
TLS2_k127_3865610_6 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000001159 197.0
TLS2_k127_3865610_7 ROK family - - - 0.000000000000000000000000000000000000000000001937 179.0
TLS2_k127_3865610_8 Transposase - - - 0.000000000000000000000000000004424 123.0
TLS2_k127_3865610_9 pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000001839 101.0
TLS2_k127_3866497_0 Type II/IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000003681 222.0
TLS2_k127_3866497_1 Type II secretion system K12510 - - 0.00000000000000000001688 103.0
TLS2_k127_3866497_2 CobQ/CobB/MinD/ParA nucleotide binding domain - - - 0.000000000000000000386 100.0
TLS2_k127_3866497_3 Type II secretion system K12511 - - 0.00000000000007985 83.0
TLS2_k127_3866497_4 SAF - - - 0.000001809 59.0
TLS2_k127_3875451_0 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 366.0
TLS2_k127_3875451_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0000000000000000000004137 98.0
TLS2_k127_3875451_2 Endonuclease/Exonuclease/phosphatase family K07004 - - 0.0000000000000000000009154 110.0
TLS2_k127_3903109_0 Inositol monophosphatase K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000002146 216.0
TLS2_k127_3903109_1 SnoaL-like domain - - - 0.0000000000000000000000000000000364 129.0
TLS2_k127_3903109_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) - - - 0.0000000000000000000000009893 107.0
TLS2_k127_3991549_0 DNA polymerase alpha chain like domain K02337 - 2.7.7.7 0.0 1178.0
TLS2_k127_3991549_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1087.0
TLS2_k127_3991549_10 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 473.0
TLS2_k127_3991549_11 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 460.0
TLS2_k127_3991549_12 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006361 467.0
TLS2_k127_3991549_13 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 422.0
TLS2_k127_3991549_14 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 430.0
TLS2_k127_3991549_15 Pfam Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 400.0
TLS2_k127_3991549_16 Belongs to the long-chain O-acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 396.0
TLS2_k127_3991549_17 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 390.0
TLS2_k127_3991549_18 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 379.0
TLS2_k127_3991549_19 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 376.0
TLS2_k127_3991549_2 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 1.526e-231 731.0
TLS2_k127_3991549_20 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 383.0
TLS2_k127_3991549_21 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 371.0
TLS2_k127_3991549_22 COGs COG0534 Na -driven multidrug efflux pump K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 367.0
TLS2_k127_3991549_23 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 381.0
TLS2_k127_3991549_24 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 361.0
TLS2_k127_3991549_25 PFAM peptidase M1, membrane alanine aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 365.0
TLS2_k127_3991549_26 pfam rok K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 350.0
TLS2_k127_3991549_27 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 362.0
TLS2_k127_3991549_28 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0008150,GO:0040007 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008884 321.0
TLS2_k127_3991549_29 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009525 323.0
TLS2_k127_3991549_3 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 4.722e-212 663.0
TLS2_k127_3991549_30 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 301.0
TLS2_k127_3991549_31 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 GO:0008150,GO:0040007 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001937 295.0
TLS2_k127_3991549_32 TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001177 281.0
TLS2_k127_3991549_33 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002532 278.0
TLS2_k127_3991549_34 Belongs to the SEDS family K03588 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008259 275.0
TLS2_k127_3991549_35 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001236 262.0
TLS2_k127_3991549_36 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000006425 259.0
TLS2_k127_3991549_37 3-methyladenine DNA glycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000003698 242.0
TLS2_k127_3991549_38 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000124 255.0
TLS2_k127_3991549_39 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000002623 239.0
TLS2_k127_3991549_4 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 2.019e-209 681.0
TLS2_k127_3991549_40 glucokinase K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000001543 229.0
TLS2_k127_3991549_41 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000002859 221.0
TLS2_k127_3991549_42 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000005457 230.0
TLS2_k127_3991549_43 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000000000000000000001148 216.0
TLS2_k127_3991549_44 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000006496 214.0
TLS2_k127_3991549_45 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.000000000000000000000000000000000000000000000000000000001271 211.0
TLS2_k127_3991549_46 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000005295 205.0
TLS2_k127_3991549_47 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000001962 209.0
TLS2_k127_3991549_48 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.1.20 0.0000000000000000000000000000000000000000000000000001932 199.0
TLS2_k127_3991549_49 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000009888 204.0
TLS2_k127_3991549_5 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 606.0
TLS2_k127_3991549_50 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000001158 192.0
TLS2_k127_3991549_51 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000001564 189.0
TLS2_k127_3991549_52 domain, Protein K07228 - - 0.00000000000000000000000000000000000000000000000002303 185.0
TLS2_k127_3991549_53 PFAM Anion-transporting ATPase - - - 0.000000000000000000000000000000000000000000000001048 188.0
TLS2_k127_3991549_54 Cytochrome C biogenesis protein transmembrane region K06196,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000002817 185.0
TLS2_k127_3991549_55 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000007406 178.0
TLS2_k127_3991549_56 PFAM HNH endonuclease - - - 0.0000000000000000000000000000000000000000000003605 178.0
TLS2_k127_3991549_57 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000991 180.0
TLS2_k127_3991549_58 membrane - - - 0.0000000000000000000000000000000000000000000298 170.0
TLS2_k127_3991549_59 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000821 178.0
TLS2_k127_3991549_6 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 568.0
TLS2_k127_3991549_60 Pfam Anion-transporting ATPase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000001518 165.0
TLS2_k127_3991549_61 TIGRFAM Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000001783 157.0
TLS2_k127_3991549_62 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000000000000000001392 145.0
TLS2_k127_3991549_63 PFAM Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000000000000001831 154.0
TLS2_k127_3991549_64 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000002747 144.0
TLS2_k127_3991549_65 COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000003823 126.0
TLS2_k127_3991549_66 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.0000000000000000000000000000004465 140.0
TLS2_k127_3991549_67 copper ion binding K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 - 0.000000000000000000000000000001091 130.0
TLS2_k127_3991549_68 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000001913 127.0
TLS2_k127_3991549_69 phosphoglycerate mutase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000003123 121.0
TLS2_k127_3991549_7 Aminotransferase class I and II K10206,K14261 GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 508.0
TLS2_k127_3991549_70 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000009787 124.0
TLS2_k127_3991549_71 Secreted repeat of unknown function - - - 0.0000000000000000000001308 109.0
TLS2_k127_3991549_72 transcriptional regulator - - - 0.0000000000000000000004035 102.0
TLS2_k127_3991549_73 Phospholipase_D-nuclease N-terminal - - - 0.0000000000000000000004512 98.0
TLS2_k127_3991549_74 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000005151 100.0
TLS2_k127_3991549_75 Major facilitator Superfamily K08369 - - 0.0000000000000000009442 100.0
TLS2_k127_3991549_76 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 - - 0.0000000000000003728 87.0
TLS2_k127_3991549_77 Protein of unknown function (DUF1232) - - - 0.0000000000000007399 86.0
TLS2_k127_3991549_78 Nuclear export factor GLE1-like protein - - - 0.000000000000004389 87.0
TLS2_k127_3991549_79 Belongs to the UPF0235 family K09131 - - 0.00000000000003338 76.0
TLS2_k127_3991549_8 tryptophan synthase activity K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 502.0
TLS2_k127_3991549_80 YacP-like NYN domain - - - 0.00000000000003457 85.0
TLS2_k127_3991549_81 PFAM zinc finger, DksA TraR C4-type K06204 - - 0.00000000000008596 78.0
TLS2_k127_3991549_82 Acyl-carrier K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000006995 81.0
TLS2_k127_3991549_83 - - - - 0.000000000005692 70.0
TLS2_k127_3991549_84 - - - - 0.00000000002564 69.0
TLS2_k127_3991549_85 YGGT family K02221 - - 0.000000000562 63.0
TLS2_k127_3991549_86 Protein of unknown function (DUF3040) - - - 0.000000001019 69.0
TLS2_k127_3991549_87 - - - - 0.000000002589 62.0
TLS2_k127_3991549_88 Cell division protein FtsQ K03589 - - 0.00000002952 64.0
TLS2_k127_3991549_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 501.0
TLS2_k127_3991549_90 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00001102 52.0
TLS2_k127_3996623_0 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 377.0
TLS2_k127_3996623_1 Conserved protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 289.0
TLS2_k127_3996623_10 Metallo-peptidase family M12 - - - 0.0006091 52.0
TLS2_k127_3996623_2 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001249 302.0
TLS2_k127_3996623_3 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003082 258.0
TLS2_k127_3996623_4 Molybdenum ABC transporter K02020 - - 0.0000000000000000000000000000000000000000000000000000001011 214.0
TLS2_k127_3996623_5 molybdate abc transporter K02018,K15496 - - 0.00000000000000000000000000000000000000000000000000003295 208.0
TLS2_k127_3996623_6 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000001362 194.0
TLS2_k127_3996623_7 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000005613 166.0
TLS2_k127_3996623_8 PBP superfamily domain - - - 0.0000000000000000000000000008894 125.0
TLS2_k127_4058168_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 385.0
TLS2_k127_4058168_1 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003699 269.0
TLS2_k127_4058168_3 Protein of unknown function (DUF3788) - - - 0.0000000000001119 76.0
TLS2_k127_4058168_4 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000007236 71.0
TLS2_k127_4073933_0 SMART AP endonuclease family 2 K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 292.0
TLS2_k127_4073933_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000001526 241.0
TLS2_k127_4073933_2 alpha-ribazole phosphatase activity K01834,K02226,K15634,K22305 - 3.1.3.3,3.1.3.73,5.4.2.11,5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000518 232.0
TLS2_k127_4073933_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000405 131.0
TLS2_k127_4073933_4 domain protein K12516 - - 0.000000000000000000000000000004303 135.0
TLS2_k127_4073933_5 - - - - 0.0000000000000000203 88.0
TLS2_k127_4073933_6 O-methyltransferase activity - - - 0.000000151 63.0
TLS2_k127_4080681_0 Fungalysin metallopeptidase (M36) - - - 0.0 1030.0
TLS2_k127_4080681_1 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 542.0
TLS2_k127_4080681_10 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004171 257.0
TLS2_k127_4080681_11 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000001378 250.0
TLS2_k127_4080681_12 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001509 250.0
TLS2_k127_4080681_13 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000001673 231.0
TLS2_k127_4080681_14 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.000000000000000000000000000000000000000000000000000000002087 203.0
TLS2_k127_4080681_15 Bacterial extracellular solute-binding protein K10232 - - 0.0000000000000000000000000000000000000000000000000000309 217.0
TLS2_k127_4080681_16 PFAM DoxX K16937 - 1.8.5.2 0.00000000000000000000000000000000000000000000000001597 189.0
TLS2_k127_4080681_17 FG-GAP repeat - - - 0.000000000000000000000123 115.0
TLS2_k127_4080681_18 heme binding K21472 - - 0.000000000001738 81.0
TLS2_k127_4080681_19 - - - - 0.00000000008513 73.0
TLS2_k127_4080681_2 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 421.0
TLS2_k127_4080681_20 - - - - 0.000000000821 62.0
TLS2_k127_4080681_21 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.0000006333 59.0
TLS2_k127_4080681_22 Pfam:Pyridox_oxidase K07005 - - 0.000001132 61.0
TLS2_k127_4080681_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008528 424.0
TLS2_k127_4080681_4 Proline racemase K01777 - 5.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 406.0
TLS2_k127_4080681_5 UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 398.0
TLS2_k127_4080681_6 Phosphoglucose isomerase K00616,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 397.0
TLS2_k127_4080681_7 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005449 426.0
TLS2_k127_4080681_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 370.0
TLS2_k127_4080681_9 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 304.0
TLS2_k127_4147332_0 Zn_pept - - - 0.0 1054.0
TLS2_k127_4147332_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 2.074e-199 632.0
TLS2_k127_4147332_10 endoribonuclease L-PSP - - - 0.0000000000000000000000000000000003172 136.0
TLS2_k127_4147332_11 Belongs to the glycosyl hydrolase 13 family K01200,K01214 - 3.2.1.41,3.2.1.68 0.00000000000000000000008513 113.0
TLS2_k127_4147332_12 - - - - 0.0000000000005061 84.0
TLS2_k127_4147332_13 metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000108 56.0
TLS2_k127_4147332_2 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 468.0
TLS2_k127_4147332_3 PFAM Sodium sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 457.0
TLS2_k127_4147332_4 Alpha-amylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 334.0
TLS2_k127_4147332_5 mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008401 287.0
TLS2_k127_4147332_6 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007697 267.0
TLS2_k127_4147332_7 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000009835 216.0
TLS2_k127_4147332_8 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000000005135 161.0
TLS2_k127_4147332_9 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000002319 149.0
TLS2_k127_41691_0 helicase activity - - - 4.412e-235 751.0
TLS2_k127_41691_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 6.938e-198 636.0
TLS2_k127_41691_10 cytochrome c oxidase - - - 0.0000000000000000000000000000000000000000000001052 179.0
TLS2_k127_41691_11 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000005681 135.0
TLS2_k127_41691_12 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000001141 133.0
TLS2_k127_41691_13 DNA-binding transcription factor activity - - - 0.000000000000000000000000000638 118.0
TLS2_k127_41691_14 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000013 113.0
TLS2_k127_41691_15 transcriptional regulator - - - 0.00000000000000000000000003223 125.0
TLS2_k127_41691_16 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000001173 110.0
TLS2_k127_41691_17 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000107 79.0
TLS2_k127_41691_18 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000223 68.0
TLS2_k127_41691_19 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. - - - 0.0001022 49.0
TLS2_k127_41691_2 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 612.0
TLS2_k127_41691_3 TIGRFAM cysteine desulfurase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 411.0
TLS2_k127_41691_4 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007575 357.0
TLS2_k127_41691_5 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006136 324.0
TLS2_k127_41691_6 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008691 303.0
TLS2_k127_41691_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002334 286.0
TLS2_k127_41691_8 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002714 271.0
TLS2_k127_41691_9 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000004865 228.0
TLS2_k127_4292537_0 Acetyl-CoA carboxylase, central region - - - 0.0 1912.0
TLS2_k127_4292537_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 2.953e-274 867.0
TLS2_k127_4292537_10 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000559 221.0
TLS2_k127_4292537_11 - - - - 0.0000000000000000000000000000000000000000000000000000000121 201.0
TLS2_k127_4292537_12 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000002037 159.0
TLS2_k127_4292537_13 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000000000000000000000000001372 138.0
TLS2_k127_4292537_14 PFAM 60 kDa inner membrane insertion protein K03217 - - 0.00000000000000000000000000000000005165 145.0
TLS2_k127_4292537_15 Putative single-stranded nucleic acids-binding domain K06346 - - 0.00000000000000000000000000787 126.0
TLS2_k127_4292537_16 cyclic nucleotide binding K10914 - - 0.0000000000000000000000001354 122.0
TLS2_k127_4292537_17 Short C-terminal domain - - - 0.00000000000000000000002538 106.0
TLS2_k127_4292537_18 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000002661 106.0
TLS2_k127_4292537_19 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000000000000000003999 90.0
TLS2_k127_4292537_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 4.892e-242 764.0
TLS2_k127_4292537_20 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000005889 96.0
TLS2_k127_4292537_21 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000001164 89.0
TLS2_k127_4292537_22 Ribosomal protein L34 K02914 - - 0.0000000001443 63.0
TLS2_k127_4292537_23 Transmembrane domain of unknown function (DUF3566) - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000004605 66.0
TLS2_k127_4292537_25 S-layer homology domain - - - 0.000000002236 71.0
TLS2_k127_4292537_26 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000004386 55.0
TLS2_k127_4292537_28 Ribonuclease P K03536 - 3.1.26.5 0.00000536 54.0
TLS2_k127_4292537_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 564.0
TLS2_k127_4292537_30 Phosphate acyltransferases - - - 0.00007506 50.0
TLS2_k127_4292537_4 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 453.0
TLS2_k127_4292537_5 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 448.0
TLS2_k127_4292537_6 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 392.0
TLS2_k127_4292537_7 DNA polymerase III beta subunit K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 302.0
TLS2_k127_4292537_8 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008582 281.0
TLS2_k127_4292537_9 Capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000001683 256.0
TLS2_k127_4364164_0 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 519.0
TLS2_k127_4364164_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 351.0
TLS2_k127_4364164_2 enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000002599 244.0
TLS2_k127_4364164_3 HD domain - - - 0.0000000000000000000000000000000000000998 161.0
TLS2_k127_4364164_4 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.00000000000000000000000006839 115.0
TLS2_k127_4364164_5 Family of unknown function (DUF5317) - - - 0.00000000000000000002081 104.0
TLS2_k127_4364164_6 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.000001809 59.0
TLS2_k127_4380857_0 Nitrite and sulphite reductase 4Fe-4S K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 611.0
TLS2_k127_4380857_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 409.0
TLS2_k127_4380857_10 Domain of unknown function (DUF4202) - - - 0.00000000001069 77.0
TLS2_k127_4380857_2 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 396.0
TLS2_k127_4380857_3 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000001217 260.0
TLS2_k127_4380857_4 Uroporphyrin-III C-methyltransferase K02303,K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000001258 220.0
TLS2_k127_4380857_5 Reduction of activated sulfate into sulfite K00390 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000002039 218.0
TLS2_k127_4380857_6 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000001539 195.0
TLS2_k127_4380857_7 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 - 0.000000000000000000000000000000000000000000000007269 180.0
TLS2_k127_4380857_8 Tetrapyrrole (Corrin/Porphyrin) Methylases K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.000000000000000000000000000000000000000000004327 183.0
TLS2_k127_4380857_9 Pfam Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000000000000000002591 149.0
TLS2_k127_4386310_0 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004959 258.0
TLS2_k127_4386310_1 - - - - 0.00000000000000000000000000000000000000000000000000004696 192.0
TLS2_k127_4386310_2 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000002534 151.0
TLS2_k127_4386310_3 PFAM cyclase family protein - - - 0.000000000000000000004717 105.0
TLS2_k127_4386310_4 Transposase - - - 0.00000000000000529 82.0
TLS2_k127_4386310_5 Phage integrase family - - - 0.00000000001561 69.0
TLS2_k127_4456604_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005743 292.0
TLS2_k127_4456604_1 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000001518 241.0
TLS2_k127_4456604_2 Histidine kinase - - - 0.000000000000000000000000000000001252 137.0
TLS2_k127_4502454_0 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000000004526 190.0
TLS2_k127_4502454_1 Type II/IV secretion system protein K02283 - - 0.000000000001204 75.0
TLS2_k127_4502454_2 Belongs to the glutaminase family K01425 - 3.5.1.2 0.00000000003169 69.0
TLS2_k127_4502454_3 CobQ/CobB/MinD/ParA nucleotide binding domain - - - 0.0000000009464 71.0
TLS2_k127_4502454_4 TIGRFAM Flp pilus assembly protein CpaB K02279 - - 0.0001138 53.0
TLS2_k127_4511349_0 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 512.0
TLS2_k127_4511349_1 TrkA-N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 449.0
TLS2_k127_4511349_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 297.0
TLS2_k127_4511349_11 DUF1704 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001562 285.0
TLS2_k127_4511349_12 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001622 287.0
TLS2_k127_4511349_13 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004644 274.0
TLS2_k127_4511349_15 Periplasmic binding protein domain K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005735 268.0
TLS2_k127_4511349_16 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006625 256.0
TLS2_k127_4511349_17 WHG domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003832 224.0
TLS2_k127_4511349_18 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000001454 226.0
TLS2_k127_4511349_19 Serine aminopeptidase, S33 K06889 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - 0.000000000000000000000000000000000000000000000000000000000002358 214.0
TLS2_k127_4511349_2 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 440.0
TLS2_k127_4511349_20 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.000000000000000000000000000000000000000000000000000000007008 222.0
TLS2_k127_4511349_21 import. Responsible for energy coupling to the transport system - - - 0.0000000000000000000000000000000000000000000000000000006847 220.0
TLS2_k127_4511349_22 CHAT domain - - - 0.000000000000000000000000000000000000002073 169.0
TLS2_k127_4511349_23 transcriptional regulator - - - 0.00000000000000000000000000000003688 136.0
TLS2_k127_4511349_24 UbiA prenyltransferase family - - - 0.00000000000000000000000000000007625 142.0
TLS2_k127_4511349_25 lactoylglutathione lyase activity - - - 0.000000000000000000000000000008694 122.0
TLS2_k127_4511349_26 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.00000000000000000000000000004739 120.0
TLS2_k127_4511349_27 Immunoglobulin-like domain of bacterial spore germination - - - 0.000000000000000000000000001485 128.0
TLS2_k127_4511349_28 Dienelactone hydrolase family - - - 0.000000000000000000000000001513 122.0
TLS2_k127_4511349_3 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 437.0
TLS2_k127_4511349_30 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000003307 93.0
TLS2_k127_4511349_31 Metallo-peptidase family M12 - - - 0.00000000000000006296 94.0
TLS2_k127_4511349_32 - - - - 0.00000000000001706 79.0
TLS2_k127_4511349_33 Collagen, type V, alpha 1 K06236,K19719,K19721 GO:0001568,GO:0001654,GO:0001944,GO:0002009,GO:0002011,GO:0003007,GO:0003674,GO:0005102,GO:0005178,GO:0005198,GO:0005201,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005576,GO:0005581,GO:0005583,GO:0005588,GO:0005604,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0006928,GO:0006950,GO:0007009,GO:0007155,GO:0007275,GO:0007423,GO:0007507,GO:0008150,GO:0008152,GO:0008201,GO:0009058,GO:0009059,GO:0009611,GO:0009653,GO:0009887,GO:0009888,GO:0009987,GO:0010256,GO:0010470,GO:0012505,GO:0016043,GO:0016477,GO:0019838,GO:0022603,GO:0022610,GO:0030198,GO:0030199,GO:0031012,GO:0031974,GO:0032501,GO:0032502,GO:0032963,GO:0032964,GO:0032991,GO:0035313,GO:0035989,GO:0040011,GO:0042060,GO:0043062,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043394,GO:0043588,GO:0043933,GO:0044319,GO:0044420,GO:0044421,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045112,GO:0045595,GO:0045596,GO:0045992,GO:0045995,GO:0048407,GO:0048513,GO:0048519,GO:0048523,GO:0048592,GO:0048729,GO:0048731,GO:0048856,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050839,GO:0050896,GO:0051093,GO:0051128,GO:0051179,GO:0051239,GO:0051241,GO:0051674,GO:0060429,GO:0061024,GO:0061448,GO:0062023,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0072358,GO:0072359,GO:0090504,GO:0090505,GO:0090596,GO:0097367,GO:0097435,GO:0098643,GO:0098644,GO:0099080,GO:0099081,GO:0099512,GO:1901576,GO:1901681,GO:1903224,GO:1903225,GO:2000026,GO:2000542 - 0.000000000008164 76.0
TLS2_k127_4511349_34 interspecies interaction between organisms K18353 - - 0.00000001595 64.0
TLS2_k127_4511349_37 depolymerase K03932 - - 0.0001213 53.0
TLS2_k127_4511349_4 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 421.0
TLS2_k127_4511349_5 import. Responsible for energy coupling to the transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 424.0
TLS2_k127_4511349_6 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 425.0
TLS2_k127_4511349_7 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 431.0
TLS2_k127_4511349_8 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 375.0
TLS2_k127_4511349_9 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 329.0
TLS2_k127_454078_0 Class II Aldolase and Adducin N-terminal domain K00068 - 1.1.1.140 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 428.0
TLS2_k127_454078_1 Phosphorylase superfamily K00757,K03784 - 2.4.2.1,2.4.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000007168 265.0
TLS2_k127_454078_2 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 0.0000000000000000008632 98.0
TLS2_k127_456622_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 2.029e-229 722.0
TLS2_k127_456622_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K12954,K12956,K17686,K21887 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0042221,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0050896,GO:0051704,GO:0071944 3.6.3.4,3.6.3.54 1.583e-205 666.0
TLS2_k127_456622_10 transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006041 254.0
TLS2_k127_456622_11 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000081 240.0
TLS2_k127_456622_12 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944 - 0.000000000000000000000000000000000000000000000000004139 183.0
TLS2_k127_456622_13 PFAM Cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000000000002819 186.0
TLS2_k127_456622_14 pyridoxamine 5-phosphate - - - 0.00000000000000000000000000001525 122.0
TLS2_k127_456622_15 Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region K21600 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010272,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097077,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000003346 119.0
TLS2_k127_456622_16 Belongs to the Fur family K03711,K09825 - - 0.00000000000000000000005457 109.0
TLS2_k127_456622_17 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000001438 93.0
TLS2_k127_456622_18 PDGLE domain K02009 - - 0.000000000000000001681 96.0
TLS2_k127_456622_19 Filamentation induced by cAMP protein fic - - - 0.00000000000001378 80.0
TLS2_k127_456622_2 DegT/DnrJ/EryC1/StrS aminotransferase family - GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 479.0
TLS2_k127_456622_20 Heavy-metal-associated domain K07213 - - 0.00000000002801 67.0
TLS2_k127_456622_21 - - - - 0.000002578 57.0
TLS2_k127_456622_22 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.0005282 50.0
TLS2_k127_456622_3 Pyridoxal-phosphate dependent enzyme K01697 - 4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 419.0
TLS2_k127_456622_4 cystathionine gamma-synthase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 418.0
TLS2_k127_456622_5 Part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 338.0
TLS2_k127_456622_6 Short-chain dehydrogenase reductase, SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 300.0
TLS2_k127_456622_7 Cobalt ABC transporter K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002577 257.0
TLS2_k127_456622_8 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000001277 258.0
TLS2_k127_456622_9 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000507 254.0
TLS2_k127_4601672_0 Molybdopterin oxidoreductase - - - 8.105e-291 915.0
TLS2_k127_4601672_1 Sulfate transporter K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 593.0
TLS2_k127_4601672_2 Tryptophan halogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 369.0
TLS2_k127_4601672_3 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006931 266.0
TLS2_k127_4601672_4 Activator of hsp90 atpase 1 family protein - - - 0.0000000000000000000000000000000000000000000000005676 179.0
TLS2_k127_4601672_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000003536 166.0
TLS2_k127_4601672_6 flavin reductase - - - 0.000000000000000000000000000000000000000000165 164.0
TLS2_k127_4601672_7 Protein of unknown function (DUF1761) - - - 0.0000008123 63.0
TLS2_k127_4601672_9 Phage integrase family - - - 0.0001531 49.0
TLS2_k127_4604808_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 503.0
TLS2_k127_4604808_1 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000503 438.0
TLS2_k127_4604808_10 SIR2-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000002918 235.0
TLS2_k127_4604808_11 pyridoxamine 5-phosphate - - - 0.000000000000000000000000000000000000000000000000000000000003927 218.0
TLS2_k127_4604808_12 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000000001156 190.0
TLS2_k127_4604808_13 Antibiotic biosynthesis monooxygenase K09932 - - 0.00000000000000000000000000000000000000000002865 176.0
TLS2_k127_4604808_14 - - - - 0.000000000000000000000000000000000007605 153.0
TLS2_k127_4604808_15 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000004087 131.0
TLS2_k127_4604808_16 DinB superfamily - - - 0.0000000000000000000000000000005129 131.0
TLS2_k127_4604808_2 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 426.0
TLS2_k127_4604808_3 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 369.0
TLS2_k127_4604808_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 364.0
TLS2_k127_4604808_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 352.0
TLS2_k127_4604808_6 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 354.0
TLS2_k127_4604808_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 329.0
TLS2_k127_4604808_8 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 329.0
TLS2_k127_4604808_9 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000008051 232.0
TLS2_k127_4606325_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.277e-255 813.0
TLS2_k127_4606325_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 5.698e-198 633.0
TLS2_k127_4606325_10 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 301.0
TLS2_k127_4606325_11 impB/mucB/samB family K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003923 282.0
TLS2_k127_4606325_12 PFAM phosphoesterase RecJ domain protein K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000004142 254.0
TLS2_k127_4606325_13 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000141 250.0
TLS2_k127_4606325_14 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000003636 244.0
TLS2_k127_4606325_15 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000001434 231.0
TLS2_k127_4606325_16 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000004037 222.0
TLS2_k127_4606325_17 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000007697 209.0
TLS2_k127_4606325_18 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.0000000000000000000000000000000000000000000000000000000003499 213.0
TLS2_k127_4606325_19 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000000000235 198.0
TLS2_k127_4606325_2 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 591.0
TLS2_k127_4606325_20 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000004272 161.0
TLS2_k127_4606325_21 SufE protein probably involved in Fe-S center assembly K02426 - - 0.00000000000000000000000000000000000000004944 158.0
TLS2_k127_4606325_22 Domain of unknown function (DUF4280) - - - 0.0000000000000000000000000000000000000004083 152.0
TLS2_k127_4606325_23 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000005596 151.0
TLS2_k127_4606325_24 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000008008 146.0
TLS2_k127_4606325_25 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000000000000000001736 143.0
TLS2_k127_4606325_26 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000006113 136.0
TLS2_k127_4606325_27 Domain of unknown function (DUF4157) - - - 0.000000000000000000000000000000007099 132.0
TLS2_k127_4606325_28 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.0000000000000000000000000000000823 144.0
TLS2_k127_4606325_29 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000002412 130.0
TLS2_k127_4606325_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 586.0
TLS2_k127_4606325_30 Endoribonuclease L-PSP - - - 0.0000000000000000000000000002251 125.0
TLS2_k127_4606325_31 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000001143 116.0
TLS2_k127_4606325_32 response regulator - - - 0.00000000000000000000002478 106.0
TLS2_k127_4606325_33 Rhodanese Homology Domain - - - 0.000000000000000000001665 98.0
TLS2_k127_4606325_34 Protein of unknown function (DUF4255) - - - 0.000000000000000000002668 103.0
TLS2_k127_4606325_35 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000003553 102.0
TLS2_k127_4606325_36 Dodecin K09165 - - 0.000000000000005467 80.0
TLS2_k127_4606325_37 Protein of unknown function (DUF503) K09764 - - 0.0000000000007673 76.0
TLS2_k127_4606325_38 TIGRFAM periplasmic serine protease, Do DeqQ family K04771 - 3.4.21.107 0.0000000000007774 81.0
TLS2_k127_4606325_39 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.00001106 55.0
TLS2_k127_4606325_4 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009524 525.0
TLS2_k127_4606325_5 Sulfurtransferase K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 487.0
TLS2_k127_4606325_6 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 419.0
TLS2_k127_4606325_7 Evidence 4 Homologs of previously reported genes of K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 384.0
TLS2_k127_4606325_8 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 324.0
TLS2_k127_4606325_9 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 306.0
TLS2_k127_4624070_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 370.0
TLS2_k127_4624070_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 346.0
TLS2_k127_4624070_2 Domain of unknown function (DUF2437) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000178 290.0
TLS2_k127_4624070_3 isomerase activity - - - 0.00000000000000000000000000000000000007242 162.0
TLS2_k127_4624070_4 pathogenesis - - - 0.0000000000000000000000000000000000001294 161.0
TLS2_k127_4744679_0 ABC transporter - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 1.357e-255 798.0
TLS2_k127_4744679_1 KR domain K00059,K00216 - 1.1.1.100,1.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000006977 233.0
TLS2_k127_4744679_2 amino acid - - - 0.00000000000000000005682 96.0
TLS2_k127_4749770_0 Belongs to the TPP enzyme family - - - 1.709e-227 730.0
TLS2_k127_4749770_1 Belongs to the malate synthase family K01638 - 2.3.3.9 2.436e-215 681.0
TLS2_k127_4749770_10 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 367.0
TLS2_k127_4749770_11 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 372.0
TLS2_k127_4749770_12 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 358.0
TLS2_k127_4749770_13 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 379.0
TLS2_k127_4749770_14 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 340.0
TLS2_k127_4749770_15 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 329.0
TLS2_k127_4749770_16 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 307.0
TLS2_k127_4749770_17 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 329.0
TLS2_k127_4749770_18 von Willebrand factor type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 300.0
TLS2_k127_4749770_19 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008163 292.0
TLS2_k127_4749770_2 Isocitrate lyase K01637 - 4.1.3.1 1.041e-202 643.0
TLS2_k127_4749770_20 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009853 284.0
TLS2_k127_4749770_21 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001765 272.0
TLS2_k127_4749770_22 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005459 277.0
TLS2_k127_4749770_23 Acetyltransferases including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006161 259.0
TLS2_k127_4749770_24 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002787 259.0
TLS2_k127_4749770_25 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003794 249.0
TLS2_k127_4749770_26 A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics K18455 GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657 3.5.1.115 0.00000000000000000000000000000000000000000000000000000000000000000001348 257.0
TLS2_k127_4749770_27 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000001738 244.0
TLS2_k127_4749770_28 Putative peptidoglycan binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000137 252.0
TLS2_k127_4749770_29 Phosphomethylpyrimidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000001526 240.0
TLS2_k127_4749770_3 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 618.0
TLS2_k127_4749770_30 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.000000000000000000000000000000000000000000000000000000000000001826 234.0
TLS2_k127_4749770_31 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000001034 238.0
TLS2_k127_4749770_32 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000001315 222.0
TLS2_k127_4749770_33 ATPase involved in DNA repair K03546 - - 0.000000000000000000000000000000000000000000000000000000001238 228.0
TLS2_k127_4749770_34 YbaK prolyl-tRNA synthetase associated region - - - 0.000000000000000000000000000000000000000000000000000007837 199.0
TLS2_k127_4749770_35 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000001813 194.0
TLS2_k127_4749770_36 methionine sulfoxide reductase K07305 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0016491,GO:0016667,GO:0016671,GO:0033743,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0055114 1.8.4.12 0.000000000000000000000000000000000000000000000000003997 190.0
TLS2_k127_4749770_37 COGs COG2380 conserved - - - 0.0000000000000000000000000000000000000000000000003755 188.0
TLS2_k127_4749770_38 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.0000000000000000000000000000000000000000000001233 187.0
TLS2_k127_4749770_39 KR domain - - - 0.000000000000000000000000000000000000000000004629 172.0
TLS2_k127_4749770_4 IrrE N-terminal-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 537.0
TLS2_k127_4749770_40 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000004127 168.0
TLS2_k127_4749770_41 L-valine transmembrane transporter activity - - - 0.000000000000000000000000000000000007155 147.0
TLS2_k127_4749770_42 50S ribosome-binding GTPase - - - 0.00000000000000000000000000000000001724 151.0
TLS2_k127_4749770_43 Phospholipase_D-nuclease N-terminal - - - 0.00000000000000000000000000000000002467 138.0
TLS2_k127_4749770_44 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000000000003424 133.0
TLS2_k127_4749770_45 Peptidase s1 and s6 chymotrypsin hap - - - 0.0000000000000000000000000000242 134.0
TLS2_k127_4749770_46 RNA recognition motif - - - 0.00000000000000000000000009897 108.0
TLS2_k127_4749770_47 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000003476 116.0
TLS2_k127_4749770_48 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000001802 104.0
TLS2_k127_4749770_49 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 0.0000000000000000004013 89.0
TLS2_k127_4749770_5 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 493.0
TLS2_k127_4749770_50 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000573 101.0
TLS2_k127_4749770_51 Ribbon-helix-helix protein, copG family - - - 0.0000000000000000006805 100.0
TLS2_k127_4749770_52 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000004762 87.0
TLS2_k127_4749770_53 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000000001051 87.0
TLS2_k127_4749770_54 DUF218 domain - - - 0.00000000000000002363 91.0
TLS2_k127_4749770_55 amine dehydrogenase activity - - - 0.00000000000000004356 95.0
TLS2_k127_4749770_56 lactoylglutathione lyase activity K05606 - 5.1.99.1 0.0000000000000004921 91.0
TLS2_k127_4749770_57 Dynamin family - - - 0.000000000000024 87.0
TLS2_k127_4749770_58 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000001761 83.0
TLS2_k127_4749770_59 cell wall binding repeat 2 K01448 - 3.5.1.28 0.00000000001052 77.0
TLS2_k127_4749770_6 Inosine-uridine preferring nucleoside hydrolase K01239 GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.2.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 422.0
TLS2_k127_4749770_60 Acetyltransferase (GNAT) family - - - 0.0000000001346 70.0
TLS2_k127_4749770_61 Phospholipase_D-nuclease N-terminal - - - 0.00000000122 63.0
TLS2_k127_4749770_62 Septum formation - - - 0.000000005926 66.0
TLS2_k127_4749770_63 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000001871 62.0
TLS2_k127_4749770_66 Branched-chain amino acid transport protein (AzlD) - - - 0.00004554 52.0
TLS2_k127_4749770_7 ATPase associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 410.0
TLS2_k127_4749770_8 Belongs to the pyruvate kinase family K00873 GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 399.0
TLS2_k127_4749770_9 PFAM cyclase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 399.0
TLS2_k127_4762447_0 Trehalose utilisation - - - 0.0 1415.0
TLS2_k127_4762447_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 387.0
TLS2_k127_4762447_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001483 243.0
TLS2_k127_4762447_3 Beta-lactamase K01286 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000001576 216.0
TLS2_k127_4762447_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000005139 187.0
TLS2_k127_4762447_5 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000233 165.0
TLS2_k127_4866642_0 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007751 302.0
TLS2_k127_4866642_1 PFAM extracellular solute-binding protein, family 5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009946 290.0
TLS2_k127_4866642_2 SMART HNH nuclease - - - 0.0000000000000000000000000000000000000000000000009144 186.0
TLS2_k127_4866642_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.000000000000000000000000000002125 130.0
TLS2_k127_4866642_4 - - - - 0.00000000001411 68.0
TLS2_k127_4866642_5 hydrolase K01048 - 3.1.1.5 0.00009942 49.0
TLS2_k127_4866642_6 Glycosyl hydrolases family 25 - - - 0.0003084 50.0
TLS2_k127_4875264_0 SMART HNH nuclease - - - 0.00000000000000005084 93.0
TLS2_k127_4875264_1 Protein of unknown function (DUF1648) - - - 0.000003812 51.0
TLS2_k127_4876985_0 Cholesterol oxidase K03333 - 1.1.3.6 9.416e-279 880.0
TLS2_k127_4876985_1 Fungalysin metallopeptidase (M36) - - - 7.242e-267 838.0
TLS2_k127_4876985_10 Magnesium transport protein CorA K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 350.0
TLS2_k127_4876985_11 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 363.0
TLS2_k127_4876985_12 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009319 313.0
TLS2_k127_4876985_13 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004881 324.0
TLS2_k127_4876985_14 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001522 282.0
TLS2_k127_4876985_15 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000311 278.0
TLS2_k127_4876985_16 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007769 290.0
TLS2_k127_4876985_17 His Kinase A (phosphoacceptor) domain K07654 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000003003 256.0
TLS2_k127_4876985_18 Formamidopyrimidine-DNA glycosylase H2TH domain K05522,K10563 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000004754 249.0
TLS2_k127_4876985_19 Putative glycosyl hydrolase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000118 235.0
TLS2_k127_4876985_2 ATP-dependent helicase C-terminal K03579 - 3.6.4.13 3.367e-246 790.0
TLS2_k127_4876985_20 MafB19-like deaminase K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000007034 204.0
TLS2_k127_4876985_21 META domain - - - 0.00000000000000000000000000000000000000000000000000005255 199.0
TLS2_k127_4876985_22 Phosphorylase superfamily - - - 0.00000000000000000000000000000000000000000000000154 184.0
TLS2_k127_4876985_23 Sporulation and spore germination - - - 0.00000000000000000000000000000000004448 151.0
TLS2_k127_4876985_24 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000005158 140.0
TLS2_k127_4876985_25 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000003086 137.0
TLS2_k127_4876985_26 DoxX - - - 0.000000000000000000000000000006443 123.0
TLS2_k127_4876985_27 PspC domain - - - 0.0000000000000000000000000003748 129.0
TLS2_k127_4876985_28 CoA-binding domain protein K06929 - - 0.000000000000000000000002465 107.0
TLS2_k127_4876985_29 thiamine-containing compound biosynthetic process K02051 - - 0.0000000009836 61.0
TLS2_k127_4876985_3 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008566 539.0
TLS2_k127_4876985_30 PspC domain K03973 - - 0.00000001895 63.0
TLS2_k127_4876985_31 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000008101 63.0
TLS2_k127_4876985_4 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 540.0
TLS2_k127_4876985_5 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 504.0
TLS2_k127_4876985_6 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 473.0
TLS2_k127_4876985_7 hydroperoxide reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 463.0
TLS2_k127_4876985_8 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 425.0
TLS2_k127_4876985_9 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 400.0
TLS2_k127_4881793_0 Pyrimidine nucleoside phosphorylase C-terminal domain K00756,K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 471.0
TLS2_k127_4881793_1 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 406.0
TLS2_k127_4881793_2 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000671 271.0
TLS2_k127_4881793_3 Electron transfer flavoprotein domain K03522 - - 0.00000000000000000000000000000000000000000000000000000000000001293 223.0
TLS2_k127_4881793_4 enzyme binding K00567,K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 0.0000000489 56.0
TLS2_k127_490454_0 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 392.0
TLS2_k127_490454_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001146 284.0
TLS2_k127_490454_2 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000111 280.0
TLS2_k127_4957526_0 Glycosylase K05522 - 4.2.99.18 0.000000000000000000000000000000000000000000000000001224 194.0
TLS2_k127_4957526_1 Domain of unknown function (DUF4032) - - - 0.0000000000000000006587 90.0
TLS2_k127_4957526_2 Protein of unknown function (DUF971) - - - 0.00000007443 57.0
TLS2_k127_4989451_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.62e-247 781.0
TLS2_k127_4989451_1 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 3.499e-232 728.0
TLS2_k127_4989451_10 Belongs to the EPSP synthase family. MurA subfamily K00790 GO:0008150,GO:0040007 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 440.0
TLS2_k127_4989451_11 protein methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 435.0
TLS2_k127_4989451_12 Ferredoxin oxidoreductase K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007829 428.0
TLS2_k127_4989451_13 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 422.0
TLS2_k127_4989451_14 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 411.0
TLS2_k127_4989451_15 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 400.0
TLS2_k127_4989451_16 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 394.0
TLS2_k127_4989451_17 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 384.0
TLS2_k127_4989451_18 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 381.0
TLS2_k127_4989451_19 UDP binding domain K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 391.0
TLS2_k127_4989451_2 Methyltransferase domain - - - 6.34e-212 718.0
TLS2_k127_4989451_20 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 369.0
TLS2_k127_4989451_21 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 365.0
TLS2_k127_4989451_22 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 336.0
TLS2_k127_4989451_23 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008612 329.0
TLS2_k127_4989451_24 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 331.0
TLS2_k127_4989451_25 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006615 325.0
TLS2_k127_4989451_26 Aldehyde dehydrogenase K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009617 317.0
TLS2_k127_4989451_27 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 322.0
TLS2_k127_4989451_28 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 307.0
TLS2_k127_4989451_29 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 315.0
TLS2_k127_4989451_3 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.181e-202 663.0
TLS2_k127_4989451_30 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 310.0
TLS2_k127_4989451_31 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 312.0
TLS2_k127_4989451_32 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001874 304.0
TLS2_k127_4989451_33 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002745 290.0
TLS2_k127_4989451_34 Beta-eliminating lyase K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000569 282.0
TLS2_k127_4989451_35 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006991 276.0
TLS2_k127_4989451_36 glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007424 273.0
TLS2_k127_4989451_37 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000002605 256.0
TLS2_k127_4989451_38 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000006548 246.0
TLS2_k127_4989451_39 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000001227 236.0
TLS2_k127_4989451_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 8.727e-202 650.0
TLS2_k127_4989451_40 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000006838 229.0
TLS2_k127_4989451_41 ATPases associated with a variety of cellular activities K01990,K09693 - 3.6.3.40 0.00000000000000000000000000000000000000000000000000000000000001243 237.0
TLS2_k127_4989451_42 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000009292 216.0
TLS2_k127_4989451_43 Nickel-containing superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000001414 213.0
TLS2_k127_4989451_44 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000002781 214.0
TLS2_k127_4989451_45 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 0.000000000000000000000000000000000000000000000000000000003385 212.0
TLS2_k127_4989451_46 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000009697 207.0
TLS2_k127_4989451_47 DNA alkylation repair - - - 0.0000000000000000000000000000000000000000000000000001693 194.0
TLS2_k127_4989451_48 Thiopurine S-methyltransferase (TPMT) - - - 0.00000000000000000000000000000000000000000000005343 176.0
TLS2_k127_4989451_49 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000001854 183.0
TLS2_k127_4989451_5 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 497.0
TLS2_k127_4989451_50 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000000000000000000188 172.0
TLS2_k127_4989451_51 ABC-2 type transporter K09692 - - 0.000000000000000000000000000000000000000007834 164.0
TLS2_k127_4989451_52 Methyltransferase domain - - - 0.000000000000000000000000000000000000003229 159.0
TLS2_k127_4989451_53 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000000000000003587 162.0
TLS2_k127_4989451_54 SpoIID LytB domain protein - - - 0.0000000000000000000000000000000000000165 165.0
TLS2_k127_4989451_55 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000000003598 150.0
TLS2_k127_4989451_56 Hydrolase of the alpha beta-hydrolase K07020 - - 0.0000000000000000000000000000000000004415 151.0
TLS2_k127_4989451_57 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000005865 135.0
TLS2_k127_4989451_58 - - - - 0.00000000000000000000000000051 130.0
TLS2_k127_4989451_59 Sulfotransferase family - - - 0.000000000000000000000003306 121.0
TLS2_k127_4989451_6 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 537.0
TLS2_k127_4989451_60 MbtH-like protein K05375,K09190 - - 0.00000000000000000000002309 104.0
TLS2_k127_4989451_61 signal peptide processing K03100 - 3.4.21.89 0.0000000000000000000004194 106.0
TLS2_k127_4989451_62 - - - - 0.00000000000000000001229 107.0
TLS2_k127_4989451_63 Glycosyl transferase, family 2 K07011 - - 0.0000000000000000006135 101.0
TLS2_k127_4989451_64 Domain of unknown function (DUF4349) - - - 0.000000000000000005635 98.0
TLS2_k127_4989451_65 NifU-like domain - - - 0.00000000000000001019 86.0
TLS2_k127_4989451_66 Metallo-peptidase family M12 - - - 0.00000000000000001835 98.0
TLS2_k127_4989451_67 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.0000000000000009446 91.0
TLS2_k127_4989451_68 Lysylphosphatidylglycerol synthase TM region K07027,K20468 - - 0.000000000000001374 89.0
TLS2_k127_4989451_69 ABC-2 family transporter protein K01992 - - 0.000000000000143 84.0
TLS2_k127_4989451_7 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 458.0
TLS2_k127_4989451_70 - - - - 0.00000000004076 74.0
TLS2_k127_4989451_71 Sulfotransferase domain - - - 0.00000008204 61.0
TLS2_k127_4989451_72 Integral membrane protein TerC family - - - 0.0000001693 59.0
TLS2_k127_4989451_73 - - - - 0.000001962 59.0
TLS2_k127_4989451_74 Glycosyl transferase, family 2 - - - 0.000003478 59.0
TLS2_k127_4989451_75 D-alanyl-D-alanine carboxypeptidase - - - 0.00000462 60.0
TLS2_k127_4989451_76 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0005094 51.0
TLS2_k127_4989451_8 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 469.0
TLS2_k127_4989451_9 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 467.0
TLS2_k127_5007495_0 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 2.253e-285 912.0
TLS2_k127_5007495_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 298.0
TLS2_k127_5007495_2 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001108 287.0
TLS2_k127_5043730_0 PFAM periplasmic binding protein K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003654 267.0
TLS2_k127_5043730_1 SIS domain K00820 - 2.6.1.16 0.00000000000001022 80.0
TLS2_k127_5043730_2 Branched-chain amino acid transport system / permease component K02057,K10440,K17209 - - 0.0000000004693 61.0
TLS2_k127_5045831_0 PFAM Endonuclease exonuclease phosphatase K07004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005196 524.0
TLS2_k127_5045831_1 photosystem II stabilization K02237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000569 486.0
TLS2_k127_5045831_2 branched-chain amino acid permease (azaleucine resistance) - - - 0.00000000000000000000000000000000000000000000000000001434 197.0
TLS2_k127_5045831_3 M6 family metalloprotease domain protein - - - 0.00000000000000000000000000000000003437 156.0
TLS2_k127_5045831_4 Branched-chain amino acid transport protein (AzlD) - - - 0.0000000000000002072 91.0
TLS2_k127_5045831_5 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000001094 67.0
TLS2_k127_5124937_0 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000009331 215.0
TLS2_k127_518416_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 461.0
TLS2_k127_518416_1 Methyltransferase type 12 - - - 0.000000000000000000000000000002678 122.0
TLS2_k127_518416_2 - - - - 0.000000000000000000000000000005237 128.0
TLS2_k127_5198136_0 ABC transporter K06147 - - 8.253e-217 689.0
TLS2_k127_5198136_1 CRISPR-associated helicase Cas3 K07012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 525.0
TLS2_k127_5198136_10 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000000000003777 225.0
TLS2_k127_5198136_11 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000001052 164.0
TLS2_k127_5198136_12 Lipoate-protein ligase - - - 0.0000000000000000000000000000000001325 151.0
TLS2_k127_5198136_13 - - - - 0.00000000000000000000000000002314 134.0
TLS2_k127_5198136_14 Ion channel - - - 0.00000000000000000000002457 111.0
TLS2_k127_5198136_16 Sodium hydrogen exchanger - - - 0.0002967 48.0
TLS2_k127_5198136_17 NUDIX domain - - - 0.0008686 51.0
TLS2_k127_5198136_2 CRISPR-associated protein GSU0053 (Cas_GSU0053) K19131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 324.0
TLS2_k127_5198136_3 - K19136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 330.0
TLS2_k127_5198136_4 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005927 298.0
TLS2_k127_5198136_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 302.0
TLS2_k127_5198136_6 CRISPR-associated protein, GSU0054 family (Cas_GSU0054) K19132 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003476 265.0
TLS2_k127_5198136_7 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine - - - 0.00000000000000000000000000000000000000000000000000000000000000003639 228.0
TLS2_k127_5198136_8 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000001557 239.0
TLS2_k127_5198136_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000001614 221.0
TLS2_k127_5225359_0 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 497.0
TLS2_k127_5225359_1 L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 446.0
TLS2_k127_5225359_10 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.0000000000000000000000000003741 122.0
TLS2_k127_5225359_2 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 406.0
TLS2_k127_5225359_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 365.0
TLS2_k127_5225359_4 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 349.0
TLS2_k127_5225359_5 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K15893 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 336.0
TLS2_k127_5225359_6 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000001338 255.0
TLS2_k127_5225359_7 acid transport system permease K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000009691 239.0
TLS2_k127_5225359_8 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 GO:0003674,GO:0003824,GO:0003872,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.11 0.000000000000000000000000000000000000000000000000000000002463 209.0
TLS2_k127_5225359_9 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000004406 162.0
TLS2_k127_5230711_0 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 1.605e-216 717.0
TLS2_k127_5230711_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 5.949e-205 670.0
TLS2_k127_5230711_10 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 310.0
TLS2_k127_5230711_11 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 302.0
TLS2_k127_5230711_12 carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008462 302.0
TLS2_k127_5230711_13 phosphoribosyltransferase K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000008056 258.0
TLS2_k127_5230711_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003076 259.0
TLS2_k127_5230711_15 transposition K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000001377 237.0
TLS2_k127_5230711_16 CYTH - - - 0.00000000000000000000000000000000000000000000000000000000000000002213 244.0
TLS2_k127_5230711_17 DNA-templated transcription, initiation - - - 0.00000000000000000000000000000000000000000000000000000000000000007877 252.0
TLS2_k127_5230711_18 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000001925 229.0
TLS2_k127_5230711_19 deaminated base DNA N-glycosylase activity K10800 - - 0.0000000000000000000000000000000000000000000000000000000003179 216.0
TLS2_k127_5230711_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 528.0
TLS2_k127_5230711_20 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.00000000000000000000000000000000000000000000000000001113 198.0
TLS2_k127_5230711_21 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000002128 198.0
TLS2_k127_5230711_22 cytochrome c oxidase K02351 - - 0.0000000000000000000000000000000000000000000007171 177.0
TLS2_k127_5230711_23 - - - - 0.0000000000000000000000000000000000000000007591 163.0
TLS2_k127_5230711_24 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000003757 168.0
TLS2_k127_5230711_25 Methyltransferase - - - 0.000000000000000000000000000000000000006385 156.0
TLS2_k127_5230711_26 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000003928 145.0
TLS2_k127_5230711_27 Transposase and inactivated derivatives K05349 - 3.2.1.21 0.000000000000000000000000000000002465 132.0
TLS2_k127_5230711_28 SnoaL-like domain - - - 0.0000000000000000000000003736 112.0
TLS2_k127_5230711_29 - - - - 0.0000000000000000000002305 105.0
TLS2_k127_5230711_3 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 506.0
TLS2_k127_5230711_30 - - - - 0.0000000000000000006141 96.0
TLS2_k127_5230711_31 - - - - 0.0000000000001432 78.0
TLS2_k127_5230711_32 Transposase and inactivated derivatives IS30 family - - - 0.00000000001145 68.0
TLS2_k127_5230711_33 Domain of unknown function (DUF4328) - - - 0.0000000004905 70.0
TLS2_k127_5230711_34 Transcriptional regulator K03655 - 3.6.4.12 0.000000001097 64.0
TLS2_k127_5230711_35 - - - - 0.00000001183 63.0
TLS2_k127_5230711_36 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000002173 61.0
TLS2_k127_5230711_37 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.0000000619 61.0
TLS2_k127_5230711_38 transposition K07497 - - 0.0000002124 53.0
TLS2_k127_5230711_39 Type I restriction-modification system methyltransferase subunit - - - 0.0000005089 58.0
TLS2_k127_5230711_4 And related metal-dependent hydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 435.0
TLS2_k127_5230711_40 Psort location Cytoplasmic, score - - - 0.000002042 52.0
TLS2_k127_5230711_41 cytochrome c oxidase, subunit III - - - 0.000003416 57.0
TLS2_k127_5230711_42 N,N-dimethylaniline monooxygenase activity K07222 - - 0.000008762 55.0
TLS2_k127_5230711_5 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 432.0
TLS2_k127_5230711_6 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 426.0
TLS2_k127_5230711_7 Phenazine biosynthesis protein PhzF - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000801 362.0
TLS2_k127_5230711_8 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 357.0
TLS2_k127_5230711_9 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 334.0
TLS2_k127_5236245_0 RecF/RecN/SMC N terminal domain K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 554.0
TLS2_k127_5236245_1 Pirin K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009175 509.0
TLS2_k127_5236245_10 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000009118 248.0
TLS2_k127_5236245_11 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000001569 226.0
TLS2_k127_5236245_12 endonuclease III K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000007067 208.0
TLS2_k127_5236245_13 DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000007904 194.0
TLS2_k127_5236245_14 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000008272 178.0
TLS2_k127_5236245_15 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000000005492 171.0
TLS2_k127_5236245_16 Protein of unknown function (DUF2469) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000004694 152.0
TLS2_k127_5236245_17 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.00000000000000000000000002675 115.0
TLS2_k127_5236245_18 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis - - - 0.00000000000000000000000004594 117.0
TLS2_k127_5236245_19 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000004149 113.0
TLS2_k127_5236245_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 484.0
TLS2_k127_5236245_20 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000002927 70.0
TLS2_k127_5236245_21 methylated DNA-protein cysteine methyltransferase - - - 0.000000000001874 71.0
TLS2_k127_5236245_22 - - - - 0.000000000004479 79.0
TLS2_k127_5236245_23 Belongs to the UPF0109 family K06960 - - 0.000000000004622 69.0
TLS2_k127_5236245_24 Uncharacterised protein family UPF0102 K07460 - - 0.0000006672 60.0
TLS2_k127_5236245_3 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 443.0
TLS2_k127_5236245_4 ATPase with chaperone activity K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009392 405.0
TLS2_k127_5236245_5 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 399.0
TLS2_k127_5236245_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 304.0
TLS2_k127_5236245_7 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 290.0
TLS2_k127_5236245_8 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004383 286.0
TLS2_k127_5236245_9 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009534 282.0
TLS2_k127_5269914_0 aminopeptidase activity K01301 - 3.4.17.21 1.941e-203 646.0
TLS2_k127_5269914_1 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006063 381.0
TLS2_k127_5269914_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 368.0
TLS2_k127_5269914_3 Dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 357.0
TLS2_k127_5269914_4 protein phosphatase 2C domain protein - - - 0.00000000000000000000000000000000000000000000001119 198.0
TLS2_k127_5269914_5 CHRD domain - - - 0.000000000000000000000902 106.0
TLS2_k127_5269914_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000004759 97.0
TLS2_k127_5269914_7 sigma factor antagonist activity K04757 - 2.7.11.1 0.00000000000000008218 89.0
TLS2_k127_5269914_8 Histidine kinase-like ATPase domain - - - 0.0000000000000007068 82.0
TLS2_k127_5269914_9 Belongs to the anti-sigma-factor antagonist family K04749 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000008085 64.0
TLS2_k127_5270969_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 2.096e-217 695.0
TLS2_k127_5270969_1 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 560.0
TLS2_k127_5270969_10 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009489 265.0
TLS2_k127_5270969_11 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001962 258.0
TLS2_k127_5270969_12 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000008209 224.0
TLS2_k127_5270969_13 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000004497 224.0
TLS2_k127_5270969_14 lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00000000000000000000000000000000000000000000000000002132 203.0
TLS2_k127_5270969_15 GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.00000000000000000000000000000000000000000000000000003615 206.0
TLS2_k127_5270969_16 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000007104 193.0
TLS2_k127_5270969_17 dehydratase - - - 0.0000000000000000000000000000000000000000001335 164.0
TLS2_k127_5270969_18 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000001193 170.0
TLS2_k127_5270969_19 FR47-like protein K15520 GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189 0.0000000000000000000000000000000000000001529 165.0
TLS2_k127_5270969_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 448.0
TLS2_k127_5270969_20 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000001199 151.0
TLS2_k127_5270969_21 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000008844 119.0
TLS2_k127_5270969_22 - - - - 0.00000000000000000000000465 108.0
TLS2_k127_5270969_23 RNA-binding protein - - - 0.000000000000000000000008685 106.0
TLS2_k127_5270969_24 endonuclease activity - - - 0.00000000000000002932 94.0
TLS2_k127_5270969_25 CDP-alcohol phosphatidyltransferase K00995,K00999 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 0.00000000000000009141 89.0
TLS2_k127_5270969_26 Triose-phosphate Transporter family - - - 0.000003072 59.0
TLS2_k127_5270969_3 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 - 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 436.0
TLS2_k127_5270969_4 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 433.0
TLS2_k127_5270969_5 TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 435.0
TLS2_k127_5270969_6 PFAM amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 331.0
TLS2_k127_5270969_7 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 310.0
TLS2_k127_5270969_8 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 297.0
TLS2_k127_5270969_9 Patched family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001041 291.0
TLS2_k127_5336233_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 549.0
TLS2_k127_5336233_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 496.0
TLS2_k127_5336233_10 Evidence 4 Homologs of previously reported genes of - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.00000000000004164 79.0
TLS2_k127_5336233_11 - - - - 0.00000000000007797 73.0
TLS2_k127_5336233_12 HNH nucleases - - - 0.0000000003459 68.0
TLS2_k127_5336233_13 HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000007649 56.0
TLS2_k127_5336233_2 PFAM Pyridoxal-dependent decarboxylase K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009533 479.0
TLS2_k127_5336233_3 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 450.0
TLS2_k127_5336233_4 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 299.0
TLS2_k127_5336233_5 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000003817 283.0
TLS2_k127_5336233_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000000000000000000000005068 190.0
TLS2_k127_5336233_7 Belongs to the P(II) protein family K04752 - - 0.000000000000000000000000000000001255 132.0
TLS2_k127_5336233_8 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000002638 128.0
TLS2_k127_5336233_9 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.000000000000000000001134 99.0
TLS2_k127_5415425_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.0 1218.0
TLS2_k127_5415425_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1060.0
TLS2_k127_5415425_10 Daunorubicin resistance ABC transporter ATP-binding subunit K01990,K18232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 434.0
TLS2_k127_5415425_11 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 382.0
TLS2_k127_5415425_12 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 373.0
TLS2_k127_5415425_13 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 367.0
TLS2_k127_5415425_14 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 350.0
TLS2_k127_5415425_15 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 358.0
TLS2_k127_5415425_16 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 355.0
TLS2_k127_5415425_17 DNA primase, small subunit K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000815 346.0
TLS2_k127_5415425_18 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006302 332.0
TLS2_k127_5415425_19 dna ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 331.0
TLS2_k127_5415425_2 Metallo-peptidase family M12B Reprolysin-like - - - 2.239e-311 985.0
TLS2_k127_5415425_20 DnaJ molecular chaperone homology domain K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 298.0
TLS2_k127_5415425_21 response regulator, receiver K02483,K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008266 314.0
TLS2_k127_5415425_22 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005337 262.0
TLS2_k127_5415425_23 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000002903 243.0
TLS2_k127_5415425_24 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001109 240.0
TLS2_k127_5415425_25 PFAM AhpC TSA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001927 236.0
TLS2_k127_5415425_26 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000003849 230.0
TLS2_k127_5415425_27 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000000000000000002779 220.0
TLS2_k127_5415425_28 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000002082 158.0
TLS2_k127_5415425_29 peptidase C60 sortase A and B - - - 0.0000000000000000000000000000000000006058 149.0
TLS2_k127_5415425_3 Heat shock 70 kDa protein K04043 - - 5.176e-250 786.0
TLS2_k127_5415425_30 Bacterial inner membrane protein - - - 0.00000000000000000000000000000000001504 143.0
TLS2_k127_5415425_31 - - - - 0.00000000000000000000000000000000001676 143.0
TLS2_k127_5415425_32 Thioesterase superfamily - - - 0.00000000000000000000000000000000007351 151.0
TLS2_k127_5415425_33 translation release factor activity - - - 0.0000000000000000000000000000000016 144.0
TLS2_k127_5415425_34 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.000000000000000000000000000000003165 139.0
TLS2_k127_5415425_35 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000000000000001264 114.0
TLS2_k127_5415425_36 - - - - 0.00000000000000000000000009613 116.0
TLS2_k127_5415425_37 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000004983 113.0
TLS2_k127_5415425_38 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000008167 103.0
TLS2_k127_5415425_39 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.0000000000000000000003354 104.0
TLS2_k127_5415425_4 His Kinase A (phosphoacceptor) domain - - - 1.041e-224 728.0
TLS2_k127_5415425_40 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000001114 98.0
TLS2_k127_5415425_41 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000002431 97.0
TLS2_k127_5415425_42 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.0000000000006958 70.0
TLS2_k127_5415425_43 NfeD-like C-terminal, partner-binding - - - 0.0000000000009961 78.0
TLS2_k127_5415425_44 - - - - 0.000000003586 64.0
TLS2_k127_5415425_45 Domain of unknown function (DUF4118) - - - 0.000002014 57.0
TLS2_k127_5415425_46 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000003085 57.0
TLS2_k127_5415425_5 PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K01281 - 3.4.14.11 1.862e-216 697.0
TLS2_k127_5415425_6 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities K01782 GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 3.074e-207 667.0
TLS2_k127_5415425_7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 3.944e-202 659.0
TLS2_k127_5415425_8 Belongs to the sigma-70 factor family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008059 572.0
TLS2_k127_5415425_9 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 459.0
TLS2_k127_554324_0 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 580.0
TLS2_k127_554324_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00140,K00823 - 1.2.1.18,1.2.1.27,2.6.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 554.0
TLS2_k127_5608061_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1244.0
TLS2_k127_5608061_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 - 3.267e-283 894.0
TLS2_k127_5608061_10 protein conserved in bacteria - - - 0.0000000000000000000001027 103.0
TLS2_k127_5608061_11 Histidine kinase K07777 - 2.7.13.3 0.00000000000000000007791 104.0
TLS2_k127_5608061_12 Methyltransferase domain - - - 0.000003165 57.0
TLS2_k127_5608061_13 PFAM Flp Fap pilin component K02651 - - 0.000007234 53.0
TLS2_k127_5608061_14 Flp pilus assembly protein CpaB K02279 - - 0.0003971 52.0
TLS2_k127_5608061_2 Type ii secretion system protein e K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009868 541.0
TLS2_k127_5608061_3 PFAM RNA binding S1 domain protein K02945 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 484.0
TLS2_k127_5608061_4 NUBPL iron-transfer P-loop NTPase K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000005522 238.0
TLS2_k127_5608061_5 Type II secretion system (T2SS), protein F K12511 - - 0.00000000000000000000000000000000000000000000000000003988 198.0
TLS2_k127_5608061_6 Type ii secretion system K12510 - - 0.0000000000000000000000000000000000000000000000009484 192.0
TLS2_k127_5608061_7 - - - - 0.000000000000000000000000000000000000001021 162.0
TLS2_k127_5608061_8 helix_turn_helix, Lux Regulon K02479 - - 0.000000000000000000000000000000000001723 149.0
TLS2_k127_5608061_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000002565 133.0
TLS2_k127_5633079_0 RNA-directed DNA polymerase (reverse transcriptase) K00986 - 2.7.7.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 482.0
TLS2_k127_5654522_0 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007856 288.0
TLS2_k127_5654522_1 spore germination - - - 0.000002697 53.0
TLS2_k127_5707720_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 6.338e-285 883.0
TLS2_k127_5707720_1 UvrD-like helicase C-terminal domain K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 8.108e-231 738.0
TLS2_k127_5707720_10 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008674 287.0
TLS2_k127_5707720_11 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000001622 202.0
TLS2_k127_5707720_12 Formyl transferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000004015 207.0
TLS2_k127_5707720_13 xylan catabolic process K03932 - - 0.00000000000000000000000000000000000000000000002673 186.0
TLS2_k127_5707720_14 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000105 176.0
TLS2_k127_5707720_15 Glyoxalase-like domain - - - 0.0000000000000000000000000000000007351 135.0
TLS2_k127_5707720_16 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006323,GO:0006996,GO:0008150,GO:0009889,GO:0009987,GO:0010556,GO:0016043,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0060255,GO:0065007,GO:0071103,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000000002044 122.0
TLS2_k127_5707720_17 Protein of unknown function (DUF2510) - - - 0.000001948 58.0
TLS2_k127_5707720_18 propanoyl-CoA C-acyltransferase activity K08764 GO:0000038,GO:0000062,GO:0000166,GO:0001676,GO:0002119,GO:0002164,GO:0003008,GO:0003674,GO:0003824,GO:0003988,GO:0005102,GO:0005215,GO:0005319,GO:0005488,GO:0005496,GO:0005504,GO:0005515,GO:0005548,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005777,GO:0005782,GO:0005783,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006694,GO:0006699,GO:0006700,GO:0006701,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006886,GO:0006996,GO:0007031,GO:0007275,GO:0007568,GO:0007610,GO:0007611,GO:0007612,GO:0007635,GO:0008104,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008207,GO:0008289,GO:0008306,GO:0008355,GO:0008525,GO:0008526,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009719,GO:0009725,GO:0009791,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010817,GO:0010876,GO:0010883,GO:0010888,GO:0010893,GO:0010941,GO:0010942,GO:0012505,GO:0014070,GO:0015031,GO:0015248,GO:0015485,GO:0015711,GO:0015748,GO:0015833,GO:0015850,GO:0015914,GO:0015918,GO:0016020,GO:0016042,GO:0016043,GO:0016053,GO:0016054,GO:0016137,GO:0016138,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0017127,GO:0017144,GO:0019216,GO:0019218,GO:0019222,GO:0019236,GO:0019395,GO:0019637,GO:0019693,GO:0019748,GO:0019751,GO:0019752,GO:0019867,GO:0019898,GO:0022611,GO:0030258,GO:0030301,GO:0030554,GO:0031090,GO:0031312,GO:0031315,GO:0031406,GO:0031907,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0031981,GO:0032101,GO:0032355,GO:0032368,GO:0032370,GO:0032371,GO:0032373,GO:0032374,GO:0032376,GO:0032377,GO:0032379,GO:0032380,GO:0032382,GO:0032383,GO:0032385,GO:0032386,GO:0032388,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032879,GO:0032934,GO:0032957,GO:0032958,GO:0032959,GO:0032991,GO:0033036,GO:0033218,GO:0033293,GO:0033365,GO:0033540,GO:0033559,GO:0033814,GO:0033865,GO:0033875,GO:0033993,GO:0034032,GO:0034440,GO:0034613,GO:0034641,GO:0034698,GO:0034699,GO:0034754,GO:0035383,GO:0036041,GO:0036042,GO:0036094,GO:0036109,GO:0036314,GO:0036315,GO:0040008,GO:0040012,GO:0040024,GO:0042048,GO:0042180,GO:0042181,GO:0042221,GO:0042445,GO:0042446,GO:0042448,GO:0042579,GO:0042802,GO:0042803,GO:0042810,GO:0042811,GO:0042886,GO:0042981,GO:0043053,GO:0043054,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043177,GO:0043178,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043434,GO:0043436,GO:0043574,GO:0043603,GO:0043647,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044550,GO:0045184,GO:0045540,GO:0045542,GO:0045834,GO:0045927,GO:0045940,GO:0046165,GO:0046173,GO:0046394,GO:0046395,GO:0046483,GO:0046889,GO:0046890,GO:0046907,GO:0046982,GO:0046983,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048580,GO:0048582,GO:0048583,GO:0048638,GO:0048639,GO:0048856,GO:0050632,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050810,GO:0050877,GO:0050890,GO:0050896,GO:0050920,GO:0051049,GO:0051050,GO:0051094,GO:0051179,GO:0051186,GO:0051234,GO:0051239,GO:0051240,GO:0051641,GO:0051649,GO:0051716,GO:0055086,GO:0055114,GO:0055115,GO:0060341,GO:0060620,GO:0061062,GO:0061063,GO:0062012,GO:0062013,GO:0065007,GO:0065008,GO:0070013,GO:0070538,GO:0070723,GO:0070727,GO:0070887,GO:0071310,GO:0071396,GO:0071397,GO:0071407,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071981,GO:0072329,GO:0072330,GO:0072521,GO:0072594,GO:0072657,GO:0072659,GO:0072662,GO:0072663,GO:0080090,GO:0090181,GO:0090205,GO:0090407,GO:0097159,GO:0097305,GO:0097306,GO:0097367,GO:0098588,GO:0098805,GO:0106118,GO:0106120,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901373,GO:1901564,GO:1901567,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901652,GO:1901657,GO:1901659,GO:1901681,GO:1901698,GO:1901700,GO:1901701,GO:1902930,GO:1902932,GO:1904069,GO:1904070,GO:1904109,GO:1904121,GO:1905952,GO:1905953,GO:1905954,GO:1990778,GO:2000026,GO:2000909,GO:2000911 2.3.1.176 0.000002082 56.0
TLS2_k127_5707720_19 - - - - 0.000007896 51.0
TLS2_k127_5707720_2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K01281 - 3.4.14.11 6.338e-214 683.0
TLS2_k127_5707720_3 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 591.0
TLS2_k127_5707720_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 572.0
TLS2_k127_5707720_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 568.0
TLS2_k127_5707720_6 AICARFT/IMPCHase bienzyme K00602 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 475.0
TLS2_k127_5707720_7 Catalyzes the reversible oxidation of malate to oxaloacetate K00016,K00024 - 1.1.1.27,1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 412.0
TLS2_k127_5707720_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 389.0
TLS2_k127_5707720_9 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 369.0
TLS2_k127_5708669_0 Endonuclease/Exonuclease/phosphatase family K07004 - - 0.000000000000000996 83.0
TLS2_k127_5708669_1 TM2 domain - - - 0.00000000002992 75.0
TLS2_k127_5708669_2 PFAM PKD domain containing protein - - - 0.0000000003612 66.0
TLS2_k127_5708669_3 Luciferase-like monooxygenase - - - 0.0003798 44.0
TLS2_k127_5728216_0 DNA photolyase K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 509.0
TLS2_k127_5728216_1 PFAM Cys Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 484.0
TLS2_k127_5728216_10 RNA polymerase K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000007734 232.0
TLS2_k127_5728216_11 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) K04047 - - 0.000000000000000000000000000000000000000000000000000000005324 206.0
TLS2_k127_5728216_12 Protein of unknown function (DUF3152) - - - 0.00000000000000000000000000000000000000000000000004764 194.0
TLS2_k127_5728216_13 phosphatase activity K05967 - - 0.000000000000000000000000000000000000000000000001482 194.0
TLS2_k127_5728216_14 Glyoxalase-like domain K05606 - 5.1.99.1 0.00000000000000000000000000000002553 143.0
TLS2_k127_5728216_15 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000345 94.0
TLS2_k127_5728216_16 Transglycosylase associated protein - - - 0.00000000000000000004642 93.0
TLS2_k127_5728216_17 antisigma factor binding K04749,K20978 - - 0.0000000000000006461 83.0
TLS2_k127_5728216_18 Belongs to the UPF0337 (CsbD) family - - - 0.00000000000003459 74.0
TLS2_k127_5728216_19 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.00000000004158 72.0
TLS2_k127_5728216_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007636 449.0
TLS2_k127_5728216_20 Copper binding proteins, plastocyanin/azurin family - - - 0.00000001312 62.0
TLS2_k127_5728216_21 anti-sigma regulatory factor K04757 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 2.7.11.1 0.000000288 61.0
TLS2_k127_5728216_22 Dodecin K09165 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000003657 55.0
TLS2_k127_5728216_23 Cation transport regulator - - - 0.00002112 55.0
TLS2_k127_5728216_3 SMART Metal-dependent phosphohydrolase, HD region K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 388.0
TLS2_k127_5728216_4 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 390.0
TLS2_k127_5728216_5 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 330.0
TLS2_k127_5728216_6 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 318.0
TLS2_k127_5728216_7 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004753 274.0
TLS2_k127_5728216_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003926 248.0
TLS2_k127_5728216_9 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000005043 243.0
TLS2_k127_5759182_0 saccharopine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 522.0
TLS2_k127_5759182_1 PFAM AMP-dependent synthetase and ligase K00666,K01897,K02182,K18661 - 6.2.1.3,6.2.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 451.0
TLS2_k127_5759182_2 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001252 275.0
TLS2_k127_5759182_3 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000008538 249.0
TLS2_k127_5759182_4 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000001341 199.0
TLS2_k127_5759182_5 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000000000000000000004104 163.0
TLS2_k127_5759182_6 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000002571 142.0
TLS2_k127_5759182_7 GyrI-like small molecule binding domain - - - 0.000001363 62.0
TLS2_k127_5770626_0 Bacterial transcriptional activator domain - - - 3.961e-286 930.0
TLS2_k127_5770626_1 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000007779 152.0
TLS2_k127_5770626_2 transposase IS116 IS110 IS902 family protein - - - 0.00000005116 59.0
TLS2_k127_5849861_0 Belongs to the GPI family K01810 - 5.3.1.9 8.781e-222 705.0
TLS2_k127_5849861_1 COG2513 PEP phosphonomutase and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002312 278.0
TLS2_k127_5849861_10 Domain of unkown function (DUF1775) - - - 0.000000000000000000000000000000000000004664 157.0
TLS2_k127_5849861_11 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000003004 148.0
TLS2_k127_5849861_12 - - - - 0.0000000000000000000000000000000000007143 152.0
TLS2_k127_5849861_13 OsmC-like protein - - - 0.0000000000000000007817 93.0
TLS2_k127_5849861_14 Putative zinc-finger - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000508 75.0
TLS2_k127_5849861_2 CopC domain K14166 - - 0.00000000000000000000000000000000000000000000000000000000266 224.0
TLS2_k127_5849861_3 PFAM LemA - - - 0.000000000000000000000000000000000000000000000000000003064 200.0
TLS2_k127_5849861_4 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000001507 213.0
TLS2_k127_5849861_5 - - - - 0.0000000000000000000000000000000000000000000000000006131 206.0
TLS2_k127_5849861_6 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000001377 184.0
TLS2_k127_5849861_7 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000981 183.0
TLS2_k127_5849861_8 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000001629 173.0
TLS2_k127_5849861_9 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000002313 154.0
TLS2_k127_5883291_0 CO dehydrogenase/acetyl-CoA synthase delta subunit K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 434.0
TLS2_k127_5883291_1 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 362.0
TLS2_k127_5883291_2 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000000000000000000000000008128 191.0
TLS2_k127_5883291_3 metal-binding protein - - - 0.000000000000000000000000000000000000000000001251 169.0
TLS2_k127_5883291_4 Virulence factor - - - 0.0000000000000000000000002181 109.0
TLS2_k127_5883291_5 FCD - - - 0.000000000000006193 77.0
TLS2_k127_5887636_0 Belongs to the peptidase S8 family K01400,K01417,K20274 - 3.4.24.28 1.69e-302 952.0
TLS2_k127_5887636_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.583e-281 872.0
TLS2_k127_5887636_10 COG NOG14600 non supervised orthologous group - - - 0.00000000000000000000000000000000000000000000004694 175.0
TLS2_k127_5887636_11 PFAM HhH-GPD family protein - - - 0.0000000000000000000000000000000000000000000001043 175.0
TLS2_k127_5887636_12 Phosphoglycolate phosphatase K01091,K06019 - 3.1.3.18,3.6.1.1 0.00000000000000000000000000000000000000000001069 180.0
TLS2_k127_5887636_13 COG0406 Fructose-2,6-bisphosphatase - - - 0.00000000000000000000000000000002092 145.0
TLS2_k127_5887636_14 Uncharacterized protein conserved in bacteria (DUF2087) - - - 0.0000000000000000000000000001813 126.0
TLS2_k127_5887636_16 Protein of unknown function (DUF3090) - - - 0.0000000000000000000009899 103.0
TLS2_k127_5887636_17 COG NOG15344 non supervised orthologous group - - - 0.000000000000001586 79.0
TLS2_k127_5887636_18 Glycosyl transferase, family 2 - - - 0.0000000000005533 69.0
TLS2_k127_5887636_19 Tetratricopeptide repeat - - - 0.000000000001451 79.0
TLS2_k127_5887636_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 501.0
TLS2_k127_5887636_20 - - - - 0.000000000009475 72.0
TLS2_k127_5887636_21 - - - - 0.000000005757 63.0
TLS2_k127_5887636_22 Single-stranded DNA-binding protein K03111 - - 0.0000001242 59.0
TLS2_k127_5887636_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 449.0
TLS2_k127_5887636_4 'catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway' K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 431.0
TLS2_k127_5887636_5 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 288.0
TLS2_k127_5887636_6 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003882 266.0
TLS2_k127_5887636_7 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000673 225.0
TLS2_k127_5887636_8 Phosphatidylinositol - - - 0.0000000000000000000000000000000000000000000000000006877 194.0
TLS2_k127_5887636_9 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.000000000000000000000000000000000000000000000000002878 192.0
TLS2_k127_5906515_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 490.0
TLS2_k127_5906515_1 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 394.0
TLS2_k127_594000_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 589.0
TLS2_k127_594000_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006431 573.0
TLS2_k127_594000_10 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007493 352.0
TLS2_k127_594000_11 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 343.0
TLS2_k127_594000_12 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 335.0
TLS2_k127_594000_13 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003712 276.0
TLS2_k127_594000_14 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004023 271.0
TLS2_k127_594000_15 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004138 278.0
TLS2_k127_594000_16 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003809 258.0
TLS2_k127_594000_17 dna ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000005455 246.0
TLS2_k127_594000_18 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000004213 223.0
TLS2_k127_594000_19 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000003109 198.0
TLS2_k127_594000_2 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 556.0
TLS2_k127_594000_20 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000003317 185.0
TLS2_k127_594000_21 Cupin domain - - - 0.000000000000000000000000000000000000003544 156.0
TLS2_k127_594000_22 CAAX protease self-immunity - - - 0.00000000000000000000000000000000006257 144.0
TLS2_k127_594000_23 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000007249 121.0
TLS2_k127_594000_24 - - - - 0.000000000000000000000000001543 126.0
TLS2_k127_594000_25 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000004429 114.0
TLS2_k127_594000_26 YqeY-like protein K09117 - - 0.0000000000003579 77.0
TLS2_k127_594000_27 Protein of unknown function (DUF3107) - - - 0.0000001608 57.0
TLS2_k127_594000_28 Domain of unknown function (DUF4282) - - - 0.000003045 57.0
TLS2_k127_594000_29 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.000467 53.0
TLS2_k127_594000_3 Dehydrogenase E1 component K21416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 497.0
TLS2_k127_594000_30 Domain of unknown function DUF21 - - - 0.000539 43.0
TLS2_k127_594000_4 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 467.0
TLS2_k127_594000_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 443.0
TLS2_k127_594000_6 (ABC) transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 452.0
TLS2_k127_594000_7 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 413.0
TLS2_k127_594000_8 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006741 377.0
TLS2_k127_594000_9 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 352.0
TLS2_k127_5945319_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1506.0
TLS2_k127_5945319_1 - - - - 7.613e-243 806.0
TLS2_k127_5945319_10 BFD-like [2Fe-2S] binding domain K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 587.0
TLS2_k127_5945319_11 homogentisate 12-dioxygenase K00451 - 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 537.0
TLS2_k127_5945319_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 548.0
TLS2_k127_5945319_13 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 546.0
TLS2_k127_5945319_14 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 544.0
TLS2_k127_5945319_15 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 516.0
TLS2_k127_5945319_16 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K16950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009299 502.0
TLS2_k127_5945319_17 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 487.0
TLS2_k127_5945319_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 469.0
TLS2_k127_5945319_19 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 467.0
TLS2_k127_5945319_2 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 8.549e-225 707.0
TLS2_k127_5945319_20 Fumarylacetoacetate (FAA) hydrolase K01555 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007388 462.0
TLS2_k127_5945319_21 FAD binding domain K21401 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 1.3.99.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 445.0
TLS2_k127_5945319_22 NhaP-type Na (K ) H antiporter K11105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 445.0
TLS2_k127_5945319_23 Cytochrome b/b6/petB K03891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 426.0
TLS2_k127_5945319_24 4-hydroxyphenylpyruvate dioxygenase K00457 - 1.13.11.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 428.0
TLS2_k127_5945319_25 pyridine nucleotide-disulfide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 407.0
TLS2_k127_5945319_26 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008093 405.0
TLS2_k127_5945319_27 NADH ubiquinone oxidoreductase, 20 Kd subunit K18007 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 396.0
TLS2_k127_5945319_28 ATPases associated with a variety of cellular activities K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 379.0
TLS2_k127_5945319_29 ABC transporter transmembrane region K06148,K16013,K16014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 378.0
TLS2_k127_5945319_3 - - - - 1.991e-215 716.0
TLS2_k127_5945319_30 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 376.0
TLS2_k127_5945319_31 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K15521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 353.0
TLS2_k127_5945319_32 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 349.0
TLS2_k127_5945319_33 2 iron, 2 sulfur cluster binding K02823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 325.0
TLS2_k127_5945319_34 Hydroxymethylglutaryl-CoA lyase K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000769 313.0
TLS2_k127_5945319_35 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 303.0
TLS2_k127_5945319_36 telomerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007375 313.0
TLS2_k127_5945319_37 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005257 277.0
TLS2_k127_5945319_38 Domain of unknown function DUF11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002866 289.0
TLS2_k127_5945319_39 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004708 269.0
TLS2_k127_5945319_4 AMP-binding enzyme K01895 - 6.2.1.1 2.436e-213 684.0
TLS2_k127_5945319_40 dehydratase K03335 - 4.2.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000005185 271.0
TLS2_k127_5945319_41 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004225 270.0
TLS2_k127_5945319_42 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006499 261.0
TLS2_k127_5945319_43 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002144 271.0
TLS2_k127_5945319_44 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000001643 252.0
TLS2_k127_5945319_45 Cytochrome b(C-terminal)/b6/petD - - - 0.00000000000000000000000000000000000000000000000000000000000000000006567 242.0
TLS2_k127_5945319_46 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000004034 227.0
TLS2_k127_5945319_47 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000005424 229.0
TLS2_k127_5945319_48 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000001768 210.0
TLS2_k127_5945319_49 - - - - 0.000000000000000000000000000000000000000000000000000000004327 200.0
TLS2_k127_5945319_5 Trehalose synthase K05343 GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576 3.2.1.1,5.4.99.16 3.956e-211 669.0
TLS2_k127_5945319_50 N-acetylmuramoyl-L-alanine amidase - - - 0.00000000000000000000000000000000000000000000000000002247 198.0
TLS2_k127_5945319_51 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000004018 203.0
TLS2_k127_5945319_52 transferase activity, transferring alkyl or aryl (other than methyl) groups K22205 - - 0.00000000000000000000000000000000000000000000000000008127 197.0
TLS2_k127_5945319_53 acetylesterase activity - - - 0.0000000000000000000000000000000000000000000000001042 202.0
TLS2_k127_5945319_54 histidyl-tRNA synthetase - - - 0.00000000000000000000000000000000000000000000001133 184.0
TLS2_k127_5945319_55 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000001223 171.0
TLS2_k127_5945319_56 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000008084 177.0
TLS2_k127_5945319_57 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.0000000000000000000000000000000000000000000009106 179.0
TLS2_k127_5945319_58 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 0.000000000000000000000000000000000000000000002318 186.0
TLS2_k127_5945319_59 enzyme of poly-gamma-glutamate biosynthesis (Capsule formation) K07282 - - 0.000000000000000000000000000000000000000000009523 177.0
TLS2_k127_5945319_6 Drug exporters of the RND superfamily K06994 - - 1.229e-202 656.0
TLS2_k127_5945319_60 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.000000000000000000000000000000000000001013 155.0
TLS2_k127_5945319_61 NADH dehydrogenase K00334 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000000000002137 149.0
TLS2_k127_5945319_62 Peptidase C26 K01951 - 6.3.5.2 0.00000000000000000000000000000000001452 154.0
TLS2_k127_5945319_63 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000001733 138.0
TLS2_k127_5945319_64 Rieske 2Fe-2S - - - 0.0000000000000000000000000000000003831 150.0
TLS2_k127_5945319_65 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000008751 149.0
TLS2_k127_5945319_66 tetR family - - - 0.000000000000000000000000000000001038 139.0
TLS2_k127_5945319_67 COGs COG3278 Cbb3-type cytochrome oxidase subunit 1 K00404,K15862 - 1.9.3.1 0.00000000000000000000000000000001254 146.0
TLS2_k127_5945319_68 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000002726 145.0
TLS2_k127_5945319_69 DNA mediated transformation K04096 - - 0.0000000000000000000000000000000336 136.0
TLS2_k127_5945319_7 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 1.176e-196 640.0
TLS2_k127_5945319_70 Protein of unknown function (DUF1667) - - - 0.000000000000000000000000000000152 138.0
TLS2_k127_5945319_71 Hydrogenase maturation protease K03605 - - 0.0000000000000000000000000000002861 139.0
TLS2_k127_5945319_72 Beta-lactamase - - - 0.000000000000000000000000000009233 134.0
TLS2_k127_5945319_73 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000002471 124.0
TLS2_k127_5945319_74 heme binding K21471,K21472 - - 0.00000000000000000000000000003668 131.0
TLS2_k127_5945319_75 phage tail region protein - - - 0.0000000000000000000000000001097 121.0
TLS2_k127_5945319_76 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000002292 122.0
TLS2_k127_5945319_77 Polysaccharide pyruvyl transferase - - - 0.000000000000000000000000002424 131.0
TLS2_k127_5945319_78 Transcriptional regulator - - - 0.000000000000000000000000002815 125.0
TLS2_k127_5945319_79 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000003043 115.0
TLS2_k127_5945319_8 Nickel-dependent hydrogenase K00436 - 1.12.1.2 3.155e-196 621.0
TLS2_k127_5945319_80 Glycosyl transferases group 1 - - - 0.00000000000000000000003261 115.0
TLS2_k127_5945319_81 Protein involved in cellulose biosynthesis - - - 0.0000000000000000002904 102.0
TLS2_k127_5945319_82 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000005097 91.0
TLS2_k127_5945319_83 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000001051 87.0
TLS2_k127_5945319_84 - - - - 0.00000000000004674 82.0
TLS2_k127_5945319_85 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000005673 84.0
TLS2_k127_5945319_86 endonuclease activity - - - 0.0000000000009217 81.0
TLS2_k127_5945319_87 Putative bacterial sensory transduction regulator - - - 0.000000000001176 78.0
TLS2_k127_5945319_88 Cytochrome c - - - 0.00000000000121 78.0
TLS2_k127_5945319_89 N-terminal domain of galactosyltransferase - - - 0.00000000001181 79.0
TLS2_k127_5945319_9 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 598.0
TLS2_k127_5945319_90 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.0000000000482 76.0
TLS2_k127_5945319_91 translation initiation factor activity - - - 0.000000003938 64.0
TLS2_k127_5945319_92 Type VI secretion system effector, Hcp K11903 - - 0.0000002227 61.0
TLS2_k127_5945319_93 Peptidoglycan-binding domain 1 protein - - - 0.000002239 59.0
TLS2_k127_5945319_94 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.000003838 54.0
TLS2_k127_5945319_96 Glutaredoxin-like domain (DUF836) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00001877 54.0
TLS2_k127_5969095_0 ornithine cyclodeaminase K01750,K19244,K19743 - 1.4.1.1,1.5.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000001525 181.0
TLS2_k127_5969095_1 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000002991 161.0
TLS2_k127_5969095_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000009479 170.0
TLS2_k127_5969095_3 Belongs to the thiolase family K00626,K00632,K07823 - 2.3.1.16,2.3.1.174,2.3.1.9 0.000000003096 59.0
TLS2_k127_5989601_0 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147 - - 1.491e-216 690.0
TLS2_k127_5989601_1 phenylalanyl-tRNA synthetase (beta subunit) K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 567.0
TLS2_k127_5989601_10 - - - - 0.00000000000000000000000000000000001195 138.0
TLS2_k127_5989601_12 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000004672 124.0
TLS2_k127_5989601_13 ORF located using Blastx - - - 0.00000000000000000000000002838 111.0
TLS2_k127_5989601_14 - - - - 0.0000000000000000000003934 99.0
TLS2_k127_5989601_16 - - - - 0.00000000000000000001477 92.0
TLS2_k127_5989601_17 ORF located using Blastx - - - 0.00000000000000001433 85.0
TLS2_k127_5989601_18 - - - - 0.0000000000000431 72.0
TLS2_k127_5989601_19 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000007118 67.0
TLS2_k127_5989601_2 cellular response to dsDNA K11211,K19302 - 2.7.1.166,3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 481.0
TLS2_k127_5989601_20 - - - - 0.0000000000358 63.0
TLS2_k127_5989601_23 - - - - 0.0000000001114 63.0
TLS2_k127_5989601_25 Cell wall-associated hydrolase - - - 0.0000000715 55.0
TLS2_k127_5989601_26 - - - - 0.0000003245 57.0
TLS2_k127_5989601_27 COG NOG15344 non supervised orthologous group - - - 0.00000109 51.0
TLS2_k127_5989601_28 ORF located using Blastx - - - 0.000001773 55.0
TLS2_k127_5989601_29 - - - - 0.00000372 50.0
TLS2_k127_5989601_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 377.0
TLS2_k127_5989601_30 - - - - 0.00006689 49.0
TLS2_k127_5989601_31 - - - - 0.0001562 45.0
TLS2_k127_5989601_32 Unextendable partial coding region - - - 0.0005913 44.0
TLS2_k127_5989601_4 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 312.0
TLS2_k127_5989601_5 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 302.0
TLS2_k127_5989601_6 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 295.0
TLS2_k127_5989601_7 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000004626 218.0
TLS2_k127_5989601_8 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000003893 163.0
TLS2_k127_5989601_9 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.00000000000000000000000000000000000000002621 162.0
TLS2_k127_599451_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 5.528e-289 903.0
TLS2_k127_599451_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 450.0
TLS2_k127_599451_10 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000002866 216.0
TLS2_k127_599451_11 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000008875 212.0
TLS2_k127_599451_12 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000001501 218.0
TLS2_k127_599451_13 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000006692 209.0
TLS2_k127_599451_14 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000002214 214.0
TLS2_k127_599451_15 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000005717 188.0
TLS2_k127_599451_16 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000004432 162.0
TLS2_k127_599451_17 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000001923 167.0
TLS2_k127_599451_18 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000002774 156.0
TLS2_k127_599451_19 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000004704 162.0
TLS2_k127_599451_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 420.0
TLS2_k127_599451_20 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000001399 141.0
TLS2_k127_599451_21 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000131 133.0
TLS2_k127_599451_22 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000001348 125.0
TLS2_k127_599451_23 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000003494 130.0
TLS2_k127_599451_24 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000002289 123.0
TLS2_k127_599451_25 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000005141 114.0
TLS2_k127_599451_26 - - - - 0.000000000000000002437 90.0
TLS2_k127_599451_27 Ribosomal protein L30 K02907 - - 0.000000000000001573 77.0
TLS2_k127_599451_28 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000001892 86.0
TLS2_k127_599451_29 Ribosomal L29 protein K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000003271 75.0
TLS2_k127_599451_3 membrane protein terC K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 381.0
TLS2_k127_599451_30 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000002139 69.0
TLS2_k127_599451_4 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000544 274.0
TLS2_k127_599451_5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001279 265.0
TLS2_k127_599451_6 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001547 270.0
TLS2_k127_599451_7 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000007793 258.0
TLS2_k127_599451_8 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000000000007837 235.0
TLS2_k127_599451_9 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001852 229.0
TLS2_k127_6013839_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 8.341e-312 978.0
TLS2_k127_6013839_1 PFAM Type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 562.0
TLS2_k127_6013839_10 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.000000000000000000000000000000000002743 149.0
TLS2_k127_6013839_11 Pilus assembly protein K02279 - - 0.0000000000000000000000000000006134 134.0
TLS2_k127_6013839_12 TadE-like protein - - - 0.000000000000000000005952 98.0
TLS2_k127_6013839_13 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.00000002817 55.0
TLS2_k127_6013839_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 377.0
TLS2_k127_6013839_3 ATPases associated with a variety of cellular activities K09812 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 331.0
TLS2_k127_6013839_4 Type ii secretion system K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003704 312.0
TLS2_k127_6013839_5 pilus assembly protein K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000002561 248.0
TLS2_k127_6013839_6 Type ii secretion system K12511 - - 0.000000000000000000000000000000000000000000000000000003195 202.0
TLS2_k127_6013839_7 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000004969 190.0
TLS2_k127_6013839_8 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000003517 174.0
TLS2_k127_6013839_9 PFAM Peptidase M23 K21471 - - 0.00000000000000000000000000000000000000002688 173.0
TLS2_k127_6043700_0 Proteasomal ATPase OB/ID domain K13527 - - 9.208e-234 737.0
TLS2_k127_6043700_1 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 - 6.3.1.19 9.019e-223 697.0
TLS2_k127_6043700_10 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000005496 266.0
TLS2_k127_6043700_11 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003327 265.0
TLS2_k127_6043700_12 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000001593 255.0
TLS2_k127_6043700_13 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000001945 246.0
TLS2_k127_6043700_14 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000002686 183.0
TLS2_k127_6043700_15 Rhomboid family - - - 0.000000000000000000000000000000000000000000001282 174.0
TLS2_k127_6043700_16 overlaps another CDS with the same product name K13573 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000222 174.0
TLS2_k127_6043700_17 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000001033 163.0
TLS2_k127_6043700_18 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.000000000000000000000000000000000000009513 149.0
TLS2_k127_6043700_19 PFAM Haloacid dehalogenase domain protein hydrolase K01101 - 3.1.3.41 0.000000000000000000000000000000000001886 148.0
TLS2_k127_6043700_2 helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 633.0
TLS2_k127_6043700_20 WYL domain K13572,K13573 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000002906 154.0
TLS2_k127_6043700_21 Belongs to the ompA family K03286 - - 0.00000000000000000000000001072 124.0
TLS2_k127_6043700_22 Diacylglycerol kinase catalytic domain (presumed) - - - 0.00000000000000000000008117 111.0
TLS2_k127_6043700_23 Acetyltransferase (GNAT) family - - - 0.0000000000000002706 91.0
TLS2_k127_6043700_24 Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation K13570 GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575 - 0.0000000005667 62.0
TLS2_k127_6043700_25 - - - - 0.00000002659 62.0
TLS2_k127_6043700_26 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.0000003868 61.0
TLS2_k127_6043700_27 - - - - 0.0001023 50.0
TLS2_k127_6043700_28 - - - - 0.0006493 49.0
TLS2_k127_6043700_3 Pup-ligase protein K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 539.0
TLS2_k127_6043700_4 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 493.0
TLS2_k127_6043700_5 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009776 448.0
TLS2_k127_6043700_6 Band 7 protein K07192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 385.0
TLS2_k127_6043700_7 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 382.0
TLS2_k127_6043700_8 phosphoserine phosphatase K01079 GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 371.0
TLS2_k127_6043700_9 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 362.0
TLS2_k127_6064602_0 alpha/beta hydrolase fold - - - 8.279e-244 772.0
TLS2_k127_6064602_1 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 1.589e-219 697.0
TLS2_k127_6064602_10 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008653 438.0
TLS2_k127_6064602_11 Periplasmic binding protein domain K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 397.0
TLS2_k127_6064602_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000395 393.0
TLS2_k127_6064602_13 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006078 359.0
TLS2_k127_6064602_14 Oxidoreductase family, C-terminal alpha beta domain K13327 - 1.1.1.384 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 351.0
TLS2_k127_6064602_15 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 337.0
TLS2_k127_6064602_16 ABC transporter K10545 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 355.0
TLS2_k127_6064602_17 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 358.0
TLS2_k127_6064602_18 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 336.0
TLS2_k127_6064602_19 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 310.0
TLS2_k127_6064602_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 7.142e-211 713.0
TLS2_k127_6064602_20 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 315.0
TLS2_k127_6064602_21 Transcriptional regulator sugar kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 312.0
TLS2_k127_6064602_22 Glycosyl Transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 288.0
TLS2_k127_6064602_23 ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003961 267.0
TLS2_k127_6064602_24 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004096 260.0
TLS2_k127_6064602_25 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002735 260.0
TLS2_k127_6064602_26 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000569 259.0
TLS2_k127_6064602_27 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000004932 271.0
TLS2_k127_6064602_28 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002788 248.0
TLS2_k127_6064602_29 Dihydrofolate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005964 238.0
TLS2_k127_6064602_3 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 612.0
TLS2_k127_6064602_30 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000002282 246.0
TLS2_k127_6064602_31 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000006049 219.0
TLS2_k127_6064602_32 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000002716 213.0
TLS2_k127_6064602_33 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000001821 204.0
TLS2_k127_6064602_34 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000004513 204.0
TLS2_k127_6064602_35 Rhs element Vgr protein - - - 0.00000000000000000000000000000000000000000000000005386 198.0
TLS2_k127_6064602_36 Domain of unknown function (DUF4380) - - - 0.0000000000000000000000000000000000000000000003071 178.0
TLS2_k127_6064602_37 Histidine kinase - - - 0.00000000000000000000000000000000000000000001606 178.0
TLS2_k127_6064602_38 negative regulation of growth - - - 0.000000000000000000000000000000000000000002158 158.0
TLS2_k127_6064602_39 Inner membrane component domain - - - 0.00000000000000000000000000000000000000009384 160.0
TLS2_k127_6064602_4 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008974 574.0
TLS2_k127_6064602_40 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000002932 125.0
TLS2_k127_6064602_41 Pfam:DUF385 - - - 0.00000000000000000000000000164 118.0
TLS2_k127_6064602_42 protein conserved in cyanobacteria - - - 0.00000000000000000000005153 105.0
TLS2_k127_6064602_43 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000003737 109.0
TLS2_k127_6064602_44 Cation transporter/ATPase, N-terminus K01537,K01539 - 3.6.3.8,3.6.3.9 0.000000000000000006617 93.0
TLS2_k127_6064602_45 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.000000000000004876 85.0
TLS2_k127_6064602_46 protein with SCP PR1 domains - - - 0.0000000007067 71.0
TLS2_k127_6064602_47 - - - - 0.000000001097 70.0
TLS2_k127_6064602_48 - - - - 0.0000001555 59.0
TLS2_k127_6064602_49 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.0000003795 54.0
TLS2_k127_6064602_5 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 569.0
TLS2_k127_6064602_50 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000008644 58.0
TLS2_k127_6064602_51 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000004009 57.0
TLS2_k127_6064602_52 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.00001072 49.0
TLS2_k127_6064602_6 Belongs to the binding-protein-dependent transport system permease family K10544 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 513.0
TLS2_k127_6064602_7 ribosome binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008821 498.0
TLS2_k127_6064602_8 Alkaline phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 451.0
TLS2_k127_6064602_9 sulphate transporter K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 435.0
TLS2_k127_608115_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.17.4.1 0.0 2742.0
TLS2_k127_608115_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 349.0
TLS2_k127_608115_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003925 258.0
TLS2_k127_608115_3 LysM domain - - - 0.0000000002169 68.0
TLS2_k127_6130522_0 Multicopper oxidase - - - 7.2e-322 999.0
TLS2_k127_6130522_1 Trehalose utilisation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004417 398.0
TLS2_k127_6130522_2 Putative methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 391.0
TLS2_k127_6130522_3 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 359.0
TLS2_k127_6130522_4 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000000000000009682 187.0
TLS2_k127_6130522_5 InterPro IPR014922 - - - 0.0000000000000000000000000000000000000000000000003886 180.0
TLS2_k127_6130522_6 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000001184 112.0
TLS2_k127_6130522_7 - - - - 0.000000000000003135 78.0
TLS2_k127_6130522_8 transcriptional regulator - - - 0.000000000000007712 75.0
TLS2_k127_6130522_9 - - - - 0.0000000002483 70.0
TLS2_k127_6180284_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1579.0
TLS2_k127_6180284_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1551.0
TLS2_k127_6180284_10 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000001797 239.0
TLS2_k127_6180284_11 Parallel beta-helix repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000001927 245.0
TLS2_k127_6180284_12 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000004721 213.0
TLS2_k127_6180284_13 Putative ATP-dependant zinc protease - - - 0.000000000000000000000000000000000000000000000007444 175.0
TLS2_k127_6180284_14 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000008161 174.0
TLS2_k127_6180284_15 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000001715 151.0
TLS2_k127_6180284_16 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000002789 151.0
TLS2_k127_6180284_17 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000272 129.0
TLS2_k127_6180284_18 - - - - 0.0000000000000000000000000000234 132.0
TLS2_k127_6180284_19 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000002516 104.0
TLS2_k127_6180284_2 IgA Peptidase M64 - - - 9.751e-285 897.0
TLS2_k127_6180284_20 Peptidase family M50 - - - 0.0000000000000000004622 99.0
TLS2_k127_6180284_21 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000005895 94.0
TLS2_k127_6180284_22 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000007036 79.0
TLS2_k127_6180284_23 toxin-antitoxin pair type II binding - - - 0.00000000000000206 81.0
TLS2_k127_6180284_24 MaoC like domain - - - 0.0000000000002937 80.0
TLS2_k127_6180284_25 Bacterial regulatory proteins, tetR family - - - 0.0000000007515 68.0
TLS2_k127_6180284_26 Cro/C1-type HTH DNA-binding domain - - - 0.000000001117 68.0
TLS2_k127_6180284_28 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000002455 57.0
TLS2_k127_6180284_3 PA domain - - - 4.614e-265 854.0
TLS2_k127_6180284_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 2.548e-197 641.0
TLS2_k127_6180284_5 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 450.0
TLS2_k127_6180284_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 379.0
TLS2_k127_6180284_7 succinylglutamate desuccinylase aspartoacylase K06987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 353.0
TLS2_k127_6180284_8 Transcriptional regulator K21744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001849 276.0
TLS2_k127_6180284_9 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005398 271.0
TLS2_k127_6229061_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 6e-208 666.0
TLS2_k127_6229061_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006751 437.0
TLS2_k127_6229061_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 428.0
TLS2_k127_6229061_3 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 322.0
TLS2_k127_6229061_4 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 299.0
TLS2_k127_6229061_5 P-loop ATPase protein family K06958 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000014 278.0
TLS2_k127_6229061_6 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000009152 236.0
TLS2_k127_6363923_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 527.0
TLS2_k127_6363923_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 302.0
TLS2_k127_6363923_2 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000951 280.0
TLS2_k127_6363923_3 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000001769 184.0
TLS2_k127_6363923_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000002216 128.0
TLS2_k127_6363923_5 - - - - 0.0003164 52.0
TLS2_k127_6410169_0 Alpha/beta-hydrolase family N-terminus - - - 1.446e-198 634.0
TLS2_k127_6410169_1 Xaa-Pro dipeptidyl-peptidase K01281 - 3.4.14.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 421.0
TLS2_k127_6410169_2 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 367.0
TLS2_k127_6410169_3 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 313.0
TLS2_k127_6410169_4 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 318.0
TLS2_k127_6410169_5 efflux transmembrane transporter activity K02004 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0051704,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000002366 221.0
TLS2_k127_6410169_6 CHAT domain - - - 0.000000000000000000000000000000000000000000000006016 197.0
TLS2_k127_6410169_7 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000001556 83.0
TLS2_k127_6410169_8 - - - - 0.0009611 52.0
TLS2_k127_647186_0 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000005057 246.0
TLS2_k127_647186_1 synthase K11779 - 2.5.1.77 0.000000000000000000000000000001255 123.0
TLS2_k127_647186_2 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.000000000000000000000004738 108.0
TLS2_k127_647186_3 Universal stress protein family - - - 0.0005224 49.0
TLS2_k127_6511960_0 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.0 1090.0
TLS2_k127_6511960_1 Glycosyl hydrolases family 2 K01192 - 3.2.1.25 6.13e-293 926.0
TLS2_k127_6511960_10 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 369.0
TLS2_k127_6511960_11 ATPase MipZ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 319.0
TLS2_k127_6511960_12 adenosine deaminase K01488,K21053 - 3.5.4.2,3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 320.0
TLS2_k127_6511960_13 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 321.0
TLS2_k127_6511960_14 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 302.0
TLS2_k127_6511960_15 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 292.0
TLS2_k127_6511960_16 SIS domain K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001307 301.0
TLS2_k127_6511960_17 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000173 289.0
TLS2_k127_6511960_18 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004102 283.0
TLS2_k127_6511960_19 PFAM EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000186 280.0
TLS2_k127_6511960_2 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 595.0
TLS2_k127_6511960_20 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000002388 281.0
TLS2_k127_6511960_21 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000308 276.0
TLS2_k127_6511960_22 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000007526 252.0
TLS2_k127_6511960_23 homoserine transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000008141 193.0
TLS2_k127_6511960_24 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000003975 170.0
TLS2_k127_6511960_25 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000002974 159.0
TLS2_k127_6511960_26 Protein of unknown function (DUF429) - - - 0.0000000000000000000000000000000000000004157 159.0
TLS2_k127_6511960_27 Haemolysin-III related K11068 - - 0.000000000000000000000000000000000000008275 154.0
TLS2_k127_6511960_28 Cell wall hydrolase autolysin K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.00000000000000000000000000000000000002088 156.0
TLS2_k127_6511960_29 Small Multidrug Resistance protein K11741 - - 0.00000000000000000000000000000000000002245 149.0
TLS2_k127_6511960_3 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000875 504.0
TLS2_k127_6511960_30 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.0000000000000000000000000000002053 128.0
TLS2_k127_6511960_31 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000009659 125.0
TLS2_k127_6511960_32 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000000000005189 104.0
TLS2_k127_6511960_33 serine threonine protein kinase - - - 0.00000000000000000000654 107.0
TLS2_k127_6511960_34 - - - - 0.0000000000000001041 89.0
TLS2_k127_6511960_35 FR47-like protein - - - 0.0000000000006549 78.0
TLS2_k127_6511960_36 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.000008304 54.0
TLS2_k127_6511960_4 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 472.0
TLS2_k127_6511960_5 PFAM Glucose Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004925 462.0
TLS2_k127_6511960_6 ROK family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 431.0
TLS2_k127_6511960_7 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 424.0
TLS2_k127_6511960_8 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008703 413.0
TLS2_k127_6511960_9 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 412.0
TLS2_k127_6538576_0 PFAM Cys Met metabolism K01761 - 4.4.1.11 6.9e-206 651.0
TLS2_k127_6538576_1 COGs COG1620 L-lactate permease K03303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003176 476.0
TLS2_k127_6538576_10 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000442 261.0
TLS2_k127_6538576_11 ANTAR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008703 259.0
TLS2_k127_6538576_12 Activator of Hsp90 ATPase 1 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002072 247.0
TLS2_k127_6538576_13 arsR family - - - 0.000000000000000000000000000000000000000000000000000005133 197.0
TLS2_k127_6538576_14 ANTAR - - - 0.000000000000000000000000000000000000000000000000002541 193.0
TLS2_k127_6538576_15 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000004618 192.0
TLS2_k127_6538576_16 aminoglycoside K00662 - 2.3.1.81 0.00000000000000000000000000000000000000000000005163 181.0
TLS2_k127_6538576_17 - - - - 0.00000000000000000000000000000000000000000003091 174.0
TLS2_k127_6538576_18 - - - - 0.00000000000000000000000000000000001822 150.0
TLS2_k127_6538576_19 DoxX K15977 - - 0.0000000000000000000000000002232 122.0
TLS2_k127_6538576_2 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 454.0
TLS2_k127_6538576_20 Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation - GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231 - 0.0000000000000000000000000008812 119.0
TLS2_k127_6538576_21 PKD domain - - - 0.000000000000000000000000001317 123.0
TLS2_k127_6538576_22 Domain of unknown function (DUF4389) - - - 0.000000000000000000000002313 113.0
TLS2_k127_6538576_23 Cytochrome c - - - 0.000000000000000004235 89.0
TLS2_k127_6538576_24 cheY-homologous receiver domain - - - 0.000000000002058 77.0
TLS2_k127_6538576_26 - - - - 0.000001146 57.0
TLS2_k127_6538576_27 Helix-turn-helix domain - - - 0.00005963 48.0
TLS2_k127_6538576_3 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 421.0
TLS2_k127_6538576_4 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004452 429.0
TLS2_k127_6538576_5 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 410.0
TLS2_k127_6538576_6 Glycosyl hydrolase family 32 K01193 - 3.2.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 375.0
TLS2_k127_6538576_7 Belongs to the glycosyl hydrolase 68 family K00692 - 2.4.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 357.0
TLS2_k127_6538576_8 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003315 265.0
TLS2_k127_6538576_9 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004278 272.0
TLS2_k127_6539107_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1231.0
TLS2_k127_6539107_1 MMPL family K06994 - - 8.272e-294 919.0
TLS2_k127_6539107_10 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 335.0
TLS2_k127_6539107_11 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 338.0
TLS2_k127_6539107_12 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 331.0
TLS2_k127_6539107_13 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 324.0
TLS2_k127_6539107_14 PFAM Metallopeptidase family M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000003601 266.0
TLS2_k127_6539107_15 Phosphoribosyl transferase domain K02825 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000002824 226.0
TLS2_k127_6539107_16 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000006321 227.0
TLS2_k127_6539107_17 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000233 224.0
TLS2_k127_6539107_18 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000003352 223.0
TLS2_k127_6539107_19 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000002203 196.0
TLS2_k127_6539107_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 5.7e-228 728.0
TLS2_k127_6539107_20 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.00000000000000000000000000000000000000000000000000002784 195.0
TLS2_k127_6539107_21 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000001573 197.0
TLS2_k127_6539107_22 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.0000000000000000000000000000000000000000000002291 186.0
TLS2_k127_6539107_23 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000171 167.0
TLS2_k127_6539107_24 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000000000000000001112 151.0
TLS2_k127_6539107_25 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000003404 131.0
TLS2_k127_6539107_26 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 - 3.1.31.1 0.0000000000000000000000000001252 129.0
TLS2_k127_6539107_27 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000113 129.0
TLS2_k127_6539107_28 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000137 121.0
TLS2_k127_6539107_29 integration host factor - - - 0.0000000000000000000000000309 114.0
TLS2_k127_6539107_3 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 4.344e-226 728.0
TLS2_k127_6539107_30 - - - - 0.00000000000000000000001465 109.0
TLS2_k127_6539107_31 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000005926 114.0
TLS2_k127_6539107_32 Bacterial Peptidase A24 N-terminal domain K02654 - 3.4.23.43 0.000000000000000000008409 101.0
TLS2_k127_6539107_33 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000008722 100.0
TLS2_k127_6539107_34 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000004 84.0
TLS2_k127_6539107_35 Preprotein translocase subunit K03210 - - 0.000000000000672 73.0
TLS2_k127_6539107_36 COG2015 Alkyl sulfatase and related hydrolases - - - 0.00000000001677 66.0
TLS2_k127_6539107_4 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 603.0
TLS2_k127_6539107_5 tRNA synthetase class II K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 531.0
TLS2_k127_6539107_6 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 439.0
TLS2_k127_6539107_7 AAA C-terminal domain K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007515 423.0
TLS2_k127_6539107_8 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 389.0
TLS2_k127_6539107_9 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 355.0
TLS2_k127_6572234_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 1.441e-305 963.0
TLS2_k127_6572234_1 Putative NAD(P)-binding K03499 - - 0.000000000000000000000000000000000000000000000000003362 193.0
TLS2_k127_6572234_2 TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000003483 194.0
TLS2_k127_6572234_3 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.000000006705 57.0
TLS2_k127_6597878_0 ABC transporter (Permease) K02004 - - 4.427e-214 694.0
TLS2_k127_6597878_1 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 2.438e-202 639.0
TLS2_k127_6597878_10 Xylose isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 365.0
TLS2_k127_6597878_11 Xylose isomerase K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 340.0
TLS2_k127_6597878_12 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 339.0
TLS2_k127_6597878_13 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 300.0
TLS2_k127_6597878_14 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001519 285.0
TLS2_k127_6597878_15 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000003962 265.0
TLS2_k127_6597878_16 Putative sugar-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000177 227.0
TLS2_k127_6597878_17 Bacterial transglutaminase-like N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000001023 217.0
TLS2_k127_6597878_18 A predicted alpha-helical domain with a conserved ER motif. - - - 0.000000000000000000000000000000000000000000000000000000001242 213.0
TLS2_k127_6597878_19 Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000318 201.0
TLS2_k127_6597878_2 A circularly permuted ATPgrasp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 545.0
TLS2_k127_6597878_20 PFAM UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000001412 188.0
TLS2_k127_6597878_21 Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0005575,GO:0005576 - 0.000000000000000000000000000000004959 132.0
TLS2_k127_6597878_22 lysyltransferase activity - - - 0.00000000000000000000000000001829 131.0
TLS2_k127_6597878_23 - - - - 0.0000000000000000000000000002027 124.0
TLS2_k127_6597878_24 Protein of unknown function (DUF3151) - - - 0.000000000000000000000000005474 111.0
TLS2_k127_6597878_25 SpoVT / AbrB like domain - - - 0.00000000000000000000000008011 109.0
TLS2_k127_6597878_26 - - - - 0.000000000000000000000001341 117.0
TLS2_k127_6597878_27 protein import K01179 - 3.2.1.4 0.0000000000000000002486 103.0
TLS2_k127_6597878_28 Putative adhesin - - - 0.000000000000000000558 98.0
TLS2_k127_6597878_29 Acetyltransferase (GNAT) family - - - 0.000000000000000007785 95.0
TLS2_k127_6597878_3 TatD related DNase K07051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 459.0
TLS2_k127_6597878_30 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.000002321 61.0
TLS2_k127_6597878_31 STAS domain - - - 0.000002716 59.0
TLS2_k127_6597878_32 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.00003744 48.0
TLS2_k127_6597878_33 S-layer homology domain - - - 0.0002279 49.0
TLS2_k127_6597878_4 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 447.0
TLS2_k127_6597878_5 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004255 438.0
TLS2_k127_6597878_6 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 401.0
TLS2_k127_6597878_7 Transketolase, pyrimidine binding domain K00167,K21417 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 385.0
TLS2_k127_6597878_8 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 368.0
TLS2_k127_6597878_9 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009736 374.0
TLS2_k127_6662109_0 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 409.0
TLS2_k127_6662109_1 Alpha-tubulin suppressor and related RCC1 domain-containing - - - 0.0000000000000000000000000000000000000000000294 188.0
TLS2_k127_6662109_2 Autotransporter beta-domain - - - 0.000000000000000000000000000006345 140.0
TLS2_k127_6662109_3 metallopeptidase activity K01193,K01212,K02809,K02810,K03332,K18775,K19668 GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044464,GO:0046352,GO:0071704,GO:1901575 2.7.1.211,3.2.1.26,3.2.1.64,3.2.1.65,3.2.1.80,3.2.1.91 0.000000000000000000003286 111.0
TLS2_k127_6662109_4 Belongs to the TPP enzyme family K01637 - 4.1.3.1 0.000000000000006938 91.0
TLS2_k127_6662109_5 cellulose binding - - - 0.0008618 54.0
TLS2_k127_6666640_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 1.191e-224 704.0
TLS2_k127_6666640_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 6.511e-223 704.0
TLS2_k127_6666640_10 May be involved in recombinational repair of damaged DNA K03631 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007808 278.0
TLS2_k127_6666640_11 Phage integrase, N-terminal SAM-like domain K04763 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000002307 259.0
TLS2_k127_6666640_12 RNA pseudouridylate synthase K06178,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000008434 235.0
TLS2_k127_6666640_13 TIGRFAM hemolysin TlyA family protein K06442 GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000001233 202.0
TLS2_k127_6666640_14 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000002719 207.0
TLS2_k127_6666640_15 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000004007 174.0
TLS2_k127_6666640_16 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000104 170.0
TLS2_k127_6666640_17 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000001159 170.0
TLS2_k127_6666640_18 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000007016 153.0
TLS2_k127_6666640_19 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000003678 147.0
TLS2_k127_6666640_2 Carboxyl transferase domain - - - 1.972e-220 696.0
TLS2_k127_6666640_20 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000000000000000000000000000005242 131.0
TLS2_k127_6666640_21 Transcriptional regulator, TraR DksA family K06204 - - 0.000000000000005467 80.0
TLS2_k127_6666640_23 Belongs to the 'phage' integrase family - - - 0.0001548 46.0
TLS2_k127_6666640_3 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005646 548.0
TLS2_k127_6666640_4 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 538.0
TLS2_k127_6666640_5 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 461.0
TLS2_k127_6666640_6 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 427.0
TLS2_k127_6666640_7 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 406.0
TLS2_k127_6666640_8 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 353.0
TLS2_k127_6666640_9 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 305.0
TLS2_k127_6678839_0 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006456 418.0
TLS2_k127_6678839_1 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 321.0
TLS2_k127_6678839_2 acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 302.0
TLS2_k127_6678839_3 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007785 253.0
TLS2_k127_6678839_4 GrpB protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000003185 235.0
TLS2_k127_6678839_5 inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000107 202.0
TLS2_k127_6678839_6 Hexapeptide repeat of succinyl-transferase - - - 0.000000000000000000008104 104.0
TLS2_k127_6678839_7 Glycosyl transferase 4-like domain K03525 - 2.7.1.33 0.00000000000000002345 95.0
TLS2_k127_6724615_0 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 2.6e-212 671.0
TLS2_k127_6724615_1 AAA ATPase domain - - - 3.302e-201 648.0
TLS2_k127_6724615_10 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000101 218.0
TLS2_k127_6724615_11 - - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000008665 185.0
TLS2_k127_6724615_12 Type II/IV secretion system protein K02283 - - 0.000000000000000000000000000000000000003047 159.0
TLS2_k127_6724615_13 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000004211 155.0
TLS2_k127_6724615_14 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000104 134.0
TLS2_k127_6724615_15 Type ii secretion system K12511 - - 0.00000000001641 78.0
TLS2_k127_6724615_16 type II secretion system K12510 - - 0.00000001742 66.0
TLS2_k127_6724615_17 PFAM Peptidoglycan-binding lysin domain - - - 0.0002232 53.0
TLS2_k127_6724615_18 - - - - 0.0002845 51.0
TLS2_k127_6724615_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 497.0
TLS2_k127_6724615_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00113 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 475.0
TLS2_k127_6724615_4 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 349.0
TLS2_k127_6724615_5 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00112 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 317.0
TLS2_k127_6724615_6 Belongs to the MIP aquaporin (TC 1.A.8) family K02440,K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 308.0
TLS2_k127_6724615_7 3-methyladenine DNA glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001311 276.0
TLS2_k127_6724615_8 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000003346 280.0
TLS2_k127_6724615_9 Chorismate mutase type II K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000002188 266.0
TLS2_k127_6804800_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 548.0
TLS2_k127_6804800_1 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 458.0
TLS2_k127_6804800_10 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 301.0
TLS2_k127_6804800_11 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003713 281.0
TLS2_k127_6804800_12 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001308 280.0
TLS2_k127_6804800_13 VanW like protein - - - 0.000000000000000000000000000000000000000000000000000000000001756 232.0
TLS2_k127_6804800_14 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000005522 214.0
TLS2_k127_6804800_15 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000009926 216.0
TLS2_k127_6804800_16 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000002401 213.0
TLS2_k127_6804800_17 Helix-turn-helix diphteria tox regulatory element K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000002634 202.0
TLS2_k127_6804800_18 Single-strand binding protein family K03111 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000004025 162.0
TLS2_k127_6804800_19 Protein of unknown function (DUF1272) K09984 - - 0.00000000000000000000000000000000000000005022 152.0
TLS2_k127_6804800_2 DnaB-like helicase N terminal domain K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 441.0
TLS2_k127_6804800_20 - - - - 0.000000000000000000000000000000000002735 148.0
TLS2_k127_6804800_21 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000006297 138.0
TLS2_k127_6804800_22 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000001118 135.0
TLS2_k127_6804800_23 DNA-binding transcription factor activity - - - 0.0000000000000000000000000002474 122.0
TLS2_k127_6804800_24 Transcriptional regulator - - - 0.00000000000000000000000004743 121.0
TLS2_k127_6804800_25 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000003352 106.0
TLS2_k127_6804800_26 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000008861 115.0
TLS2_k127_6804800_27 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000001161 96.0
TLS2_k127_6804800_28 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.0000000000000006375 86.0
TLS2_k127_6804800_29 - - - - 0.000000000000007398 84.0
TLS2_k127_6804800_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 387.0
TLS2_k127_6804800_30 Uroporphyrinogen-III synthase HemD K01719,K13542 - 2.1.1.107,4.2.1.75 0.000001513 61.0
TLS2_k127_6804800_4 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 385.0
TLS2_k127_6804800_5 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 383.0
TLS2_k127_6804800_6 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004606 367.0
TLS2_k127_6804800_7 Coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 321.0
TLS2_k127_6804800_8 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 312.0
TLS2_k127_6804800_9 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 305.0
TLS2_k127_6856803_0 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 365.0
TLS2_k127_6856803_1 PFAM Integral membrane protein TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004535 262.0
TLS2_k127_6927762_0 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K11085 - - 3.44e-213 677.0
TLS2_k127_6927762_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006415 460.0
TLS2_k127_6927762_10 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000005068 129.0
TLS2_k127_6927762_12 Universal stress protein family - - - 0.00000000000006467 77.0
TLS2_k127_6927762_2 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 310.0
TLS2_k127_6927762_3 Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 297.0
TLS2_k127_6927762_4 Intracellular protease, PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000000001939 266.0
TLS2_k127_6927762_5 Methyltransferase K00563 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052912,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.187 0.0000000000000000000000000000000000000000000000000000000000000000000000000008246 269.0
TLS2_k127_6927762_6 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000002874 218.0
TLS2_k127_6927762_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000005154 190.0
TLS2_k127_6927762_8 menaquinone-dependent protoporphyrinogen oxidase activity K00230 - 1.3.5.3 0.00000000000000000000000000000000000000001452 164.0
TLS2_k127_6927762_9 Cbs domain - - - 0.000000000000000000000000000000000008808 142.0
TLS2_k127_6939597_0 Bacterial pullanase-associated domain - - - 0.0 1156.0
TLS2_k127_6982189_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000006722 223.0
TLS2_k127_6982189_1 regulation of methylation-dependent chromatin silencing K07454 - - 0.000000000000000000000000000000000000000000001891 169.0
TLS2_k127_6982189_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000001609 85.0
TLS2_k127_6982189_3 - - - - 0.00000000506 63.0
TLS2_k127_6988511_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 6.715e-303 955.0
TLS2_k127_6988511_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 5.953e-246 781.0
TLS2_k127_6988511_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 407.0
TLS2_k127_6988511_11 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 389.0
TLS2_k127_6988511_12 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 422.0
TLS2_k127_6988511_13 HELICc2 K03722 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006983 397.0
TLS2_k127_6988511_14 phosphate starvation-inducible protein PhoH K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008161 374.0
TLS2_k127_6988511_15 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 362.0
TLS2_k127_6988511_16 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009343 345.0
TLS2_k127_6988511_17 Bacterial periplasmic substrate-binding proteins K02030,K10005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 331.0
TLS2_k127_6988511_18 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 316.0
TLS2_k127_6988511_19 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 329.0
TLS2_k127_6988511_2 transferase activity, transferring glycosyl groups - - - 8.333e-203 666.0
TLS2_k127_6988511_20 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001434 288.0
TLS2_k127_6988511_21 amino acid transport K09970,K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003624 284.0
TLS2_k127_6988511_22 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K14215,K21273 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000821 269.0
TLS2_k127_6988511_23 7TM receptor with intracellular HD hydrolase K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000651 286.0
TLS2_k127_6988511_24 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000854 269.0
TLS2_k127_6988511_25 acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003905 268.0
TLS2_k127_6988511_26 rRNA methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002306 243.0
TLS2_k127_6988511_27 ComEC Rec2-related protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000006046 254.0
TLS2_k127_6988511_28 Transporter associated domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000006244 238.0
TLS2_k127_6988511_29 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000002632 191.0
TLS2_k127_6988511_3 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 598.0
TLS2_k127_6988511_30 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000009373 185.0
TLS2_k127_6988511_31 FCD K05799 - - 0.00000000000000000000000000000000000000000006421 178.0
TLS2_k127_6988511_32 Response regulator receiver domain - - - 0.00000000000000000000000000000000000000002851 155.0
TLS2_k127_6988511_33 - - - - 0.000000000000000000000000000000000000001141 151.0
TLS2_k127_6988511_34 ComEA protein K02237 - - 0.0000000000000000000000000000000000005823 151.0
TLS2_k127_6988511_35 HEAT repeats - - - 0.00000000000000000000000000000006523 143.0
TLS2_k127_6988511_36 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.0000000000000000000000000000003625 130.0
TLS2_k127_6988511_37 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000001646 126.0
TLS2_k127_6988511_38 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.000000000000000000006385 96.0
TLS2_k127_6988511_39 ASNC family K03718 - - 0.00000000000000002681 88.0
TLS2_k127_6988511_4 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 529.0
TLS2_k127_6988511_40 bacterial-type flagellum organization - - - 0.0000000000000001071 81.0
TLS2_k127_6988511_41 Helix-turn-helix domain - - - 0.0000000000000004921 81.0
TLS2_k127_6988511_42 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000006435 80.0
TLS2_k127_6988511_43 CAAX protease self-immunity K07052 - - 0.0000000000000007972 87.0
TLS2_k127_6988511_44 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000001574 72.0
TLS2_k127_6988511_45 - - - - 0.00000008592 59.0
TLS2_k127_6988511_46 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.0000002359 62.0
TLS2_k127_6988511_47 Protein of unknown function (DUF433) - - - 0.000000653 53.0
TLS2_k127_6988511_48 manually curated - - - 0.00000228 51.0
TLS2_k127_6988511_49 Protein of unknown function (DUF433) - - - 0.0000102 49.0
TLS2_k127_6988511_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007029 429.0
TLS2_k127_6988511_50 - - - - 0.00002835 50.0
TLS2_k127_6988511_6 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 420.0
TLS2_k127_6988511_7 transport, permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 415.0
TLS2_k127_6988511_8 GGDEF domain K01768,K02488,K07676,K10715,K20976 GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3,2.7.7.65,4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 426.0
TLS2_k127_6988511_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 426.0
TLS2_k127_699925_0 drug exporters of the RND superfamily K06994 - - 6.853e-279 878.0
TLS2_k127_699925_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 7.12e-246 787.0
TLS2_k127_699925_10 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004047 533.0
TLS2_k127_699925_11 Phenylacetate-CoA oxygenase K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008531 520.0
TLS2_k127_699925_12 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008724 462.0
TLS2_k127_699925_13 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 468.0
TLS2_k127_699925_14 Alpha/beta-hydrolase family N-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 466.0
TLS2_k127_699925_15 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K12369 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007898 445.0
TLS2_k127_699925_16 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 429.0
TLS2_k127_699925_17 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 430.0
TLS2_k127_699925_18 PFAM extracellular solute-binding protein family 1 K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 426.0
TLS2_k127_699925_19 Carbon-nitrogen hydrolase K01501 - 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 397.0
TLS2_k127_699925_2 AMP-binding enzyme K01897 - 6.2.1.3 2.06e-241 768.0
TLS2_k127_699925_20 DNA alkylation repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 396.0
TLS2_k127_699925_21 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 389.0
TLS2_k127_699925_22 pfam abc K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 383.0
TLS2_k127_699925_23 Oxidoreductase FAD-binding domain K02613 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 382.0
TLS2_k127_699925_24 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 383.0
TLS2_k127_699925_25 RmlD substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 376.0
TLS2_k127_699925_26 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 355.0
TLS2_k127_699925_27 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K12370 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 360.0
TLS2_k127_699925_28 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 339.0
TLS2_k127_699925_29 Carbohydrate ABC transporter ATP-binding protein, CUT1 family K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 350.0
TLS2_k127_699925_3 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 4.478e-234 745.0
TLS2_k127_699925_30 phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 336.0
TLS2_k127_699925_31 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 326.0
TLS2_k127_699925_32 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 317.0
TLS2_k127_699925_33 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 312.0
TLS2_k127_699925_34 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 308.0
TLS2_k127_699925_35 phenylacetic acid degradation protein K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 310.0
TLS2_k127_699925_36 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 308.0
TLS2_k127_699925_37 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001291 279.0
TLS2_k127_699925_38 binding-protein-dependent transport systems inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001095 262.0
TLS2_k127_699925_39 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003992 249.0
TLS2_k127_699925_4 cellulose binding - - - 1.131e-217 713.0
TLS2_k127_699925_40 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000001992 238.0
TLS2_k127_699925_41 fmn reductase K00299 - 1.5.1.38 0.00000000000000000000000000000000000000000000000000000000000000004345 241.0
TLS2_k127_699925_42 His Kinase A (phosphoacceptor) domain K07768 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000001829 236.0
TLS2_k127_699925_43 succinate dehydrogenase K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000006409 228.0
TLS2_k127_699925_44 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000001424 241.0
TLS2_k127_699925_45 ABC-type branched-chain amino acid transport - - - 0.000000000000000000000000000000000000000000000000000000000000028 234.0
TLS2_k127_699925_46 Transcriptional regulatory protein, C terminal K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000166 224.0
TLS2_k127_699925_47 Domain present in PSD-95, Dlg, and ZO-1/2. K08372 - - 0.00000000000000000000000000000000000000000000000000001098 208.0
TLS2_k127_699925_48 - - - - 0.0000000000000000000000000000000000000000000000000001299 197.0
TLS2_k127_699925_49 Iron-sulfur cluster assembly protein K02612 - - 0.0000000000000000000000000000000000000000000000000002596 195.0
TLS2_k127_699925_5 Luciferase-like monooxygenase - - - 6.44e-208 649.0
TLS2_k127_699925_50 Belongs to the peptidase S16 family K07177 - - 0.000000000000000000000000000000000000000000000000009428 197.0
TLS2_k127_699925_51 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000003412 176.0
TLS2_k127_699925_52 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000002007 169.0
TLS2_k127_699925_53 BioY family K03523 - - 0.00000000000000000000000000000000000000000003122 173.0
TLS2_k127_699925_54 Peptidoglycan-binding domain 1 protein K01448,K22278 - 3.5.1.104,3.5.1.28 0.00000000000000000000000000000000000000004133 162.0
TLS2_k127_699925_55 SIR2-like domain - - - 0.0000000000000000000000000000000000000000884 167.0
TLS2_k127_699925_56 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000002157 153.0
TLS2_k127_699925_57 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000006651 166.0
TLS2_k127_699925_58 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000002357 154.0
TLS2_k127_699925_59 PFAM Uncharacterised conserved protein (DUF2342) - - - 0.000000000000000000000000000000000001789 153.0
TLS2_k127_699925_6 Aldehyde dehydrogenase family - - - 7.743e-200 636.0
TLS2_k127_699925_60 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.00000000000000000000000000000000003859 139.0
TLS2_k127_699925_61 Phenylacetate-CoA oxygenase K02610 - - 0.0000000000000000000000000000000001531 140.0
TLS2_k127_699925_62 Endonuclease Exonuclease Phosphatase - - - 0.0000000000000000000000000000000001846 141.0
TLS2_k127_699925_63 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000009147 124.0
TLS2_k127_699925_64 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.00000000000000000000000000006342 118.0
TLS2_k127_699925_65 CAAX protease self-immunity K07052 - - 0.000000000000000000000000007368 127.0
TLS2_k127_699925_66 - - - - 0.0000000000000000000000002173 122.0
TLS2_k127_699925_67 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000001084 112.0
TLS2_k127_699925_68 - - - - 0.00000000000000000006036 106.0
TLS2_k127_699925_69 PBS lyase HEAT-like repeat - - - 0.000000000000000009251 91.0
TLS2_k127_699925_7 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 2.807e-199 656.0
TLS2_k127_699925_70 - - - - 0.000000000000001256 87.0
TLS2_k127_699925_71 Thioesterase superfamily K02614 - - 0.0000000000001209 78.0
TLS2_k127_699925_72 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000005031 60.0
TLS2_k127_699925_73 antisigma factor binding K03598 - - 0.00000003129 66.0
TLS2_k127_699925_74 - - - - 0.00000009015 61.0
TLS2_k127_699925_75 DivIVA protein - - - 0.00004423 57.0
TLS2_k127_699925_8 ABC-type dipeptide transport system, periplasmic component K02035,K12368 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 603.0
TLS2_k127_699925_9 Belongs to the thiolase family K00626,K00632,K07823 - 2.3.1.16,2.3.1.174,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 552.0
TLS2_k127_7073465_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 4.422e-227 732.0
TLS2_k127_7073465_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 531.0
TLS2_k127_7073465_10 Rhomboid family K19225 - 3.4.21.105 0.0000000000000000000000000000000000000000000000000000000003593 212.0
TLS2_k127_7073465_11 membrane - - - 0.0000000000000000000000000000000000000000000000000000005501 202.0
TLS2_k127_7073465_12 Cys-tRNA(Pro) hydrolase activity K03976,K19055 - - 0.0000000000000000000000000000000000000000004808 164.0
TLS2_k127_7073465_13 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000376 169.0
TLS2_k127_7073465_14 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000000000000000000005704 164.0
TLS2_k127_7073465_15 carbohydrate metabolic process - - - 0.000000000000000000000000000000000001571 149.0
TLS2_k127_7073465_16 Bacterial-like globin K06886 - - 0.00000000000000000000000000000000000212 143.0
TLS2_k127_7073465_17 FR47-like protein - - - 0.0000000000000000000000000004076 127.0
TLS2_k127_7073465_18 - - - - 0.0000000000000000002249 100.0
TLS2_k127_7073465_19 S-layer homology domain - - - 0.000000000000001789 89.0
TLS2_k127_7073465_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 527.0
TLS2_k127_7073465_20 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000001482 85.0
TLS2_k127_7073465_21 Bacterial regulatory proteins, tetR family - - - 0.00000000005698 71.0
TLS2_k127_7073465_22 PIN domain - - - 0.0000000001443 63.0
TLS2_k127_7073465_23 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor - - - 0.0000000007364 70.0
TLS2_k127_7073465_24 Protein of unknown function (DUF3352) - - - 0.0000002556 64.0
TLS2_k127_7073465_3 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 448.0
TLS2_k127_7073465_4 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 382.0
TLS2_k127_7073465_5 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 393.0
TLS2_k127_7073465_6 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 322.0
TLS2_k127_7073465_7 AIR synthase related protein, C-terminal domain K01933 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 306.0
TLS2_k127_7073465_8 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000003535 261.0
TLS2_k127_7073465_9 TIGRFAM Methylglyoxal synthase K01734 - 4.2.3.3 0.00000000000000000000000000000000000000000000000000000000000004671 219.0
TLS2_k127_7102559_0 PA domain - - - 0.0 1155.0
TLS2_k127_7102559_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 0.0 1101.0
TLS2_k127_7102559_10 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007482 373.0
TLS2_k127_7102559_11 GDP-D-mannose dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005848 363.0
TLS2_k127_7102559_12 potassium uptake protein TrkH K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 359.0
TLS2_k127_7102559_13 PFAM binding-protein-dependent transport systems inner membrane component K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 361.0
TLS2_k127_7102559_14 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 309.0
TLS2_k127_7102559_15 permease, DMT superfamily K11939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 311.0
TLS2_k127_7102559_16 PFAM Type II secretion system protein E K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 304.0
TLS2_k127_7102559_17 epimerase K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 298.0
TLS2_k127_7102559_18 PFAM binding-protein-dependent transport systems inner membrane component K15772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 293.0
TLS2_k127_7102559_19 Pfam:Zinicin_2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002797 285.0
TLS2_k127_7102559_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.87e-255 804.0
TLS2_k127_7102559_20 Alanine dehydrogenase/PNT, C-terminal domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008126 290.0
TLS2_k127_7102559_21 Bacterial extracellular solute-binding protein K15770 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002982 279.0
TLS2_k127_7102559_22 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000004276 271.0
TLS2_k127_7102559_23 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000001651 249.0
TLS2_k127_7102559_24 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000002055 257.0
TLS2_k127_7102559_25 haloacid dehalogenase-like hydrolase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000004375 253.0
TLS2_k127_7102559_26 Polyprenyl synthetase K00805 - 2.5.1.30 0.000000000000000000000000000000000000000000000000000000000000000000001099 248.0
TLS2_k127_7102559_27 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000005003 226.0
TLS2_k127_7102559_28 Sap, sulfolipid-1-addressing protein - - - 0.000000000000000000000000000000000000000000000000000000000000005313 225.0
TLS2_k127_7102559_29 Uracil DNA glycosylase superfamily K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000003286 216.0
TLS2_k127_7102559_3 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 2.481e-232 736.0
TLS2_k127_7102559_30 PFAM Glycosyl transferases group 1 K13668 GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 0.000000000000000000000000000000000000000000000000000000000000838 230.0
TLS2_k127_7102559_31 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000008353 216.0
TLS2_k127_7102559_32 Uracil DNA glycosylase superfamily K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.000000000000000000000000000000000000000000000000000002464 194.0
TLS2_k127_7102559_33 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000007582 189.0
TLS2_k127_7102559_34 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000000000000007706 148.0
TLS2_k127_7102559_35 TrkA-N domain K03499 - - 0.00000000000000000000000000000000001559 143.0
TLS2_k127_7102559_36 domain protein K03499 - - 0.00000000000000000000000000000000005728 148.0
TLS2_k127_7102559_37 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000001248 151.0
TLS2_k127_7102559_38 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000614 143.0
TLS2_k127_7102559_39 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.0000000000000000000000000000009415 136.0
TLS2_k127_7102559_4 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 556.0
TLS2_k127_7102559_40 Belongs to the phosphoglycerate mutase family - - - 0.00000000000000000000000000005553 132.0
TLS2_k127_7102559_41 CGNR zinc finger - - - 0.0000000000000000000000000001176 124.0
TLS2_k127_7102559_42 Rossmann-like domain - - - 0.000000000000000000000000003524 124.0
TLS2_k127_7102559_43 - - - - 0.000000000000000000000006824 109.0
TLS2_k127_7102559_44 Belongs to the phosphoglycerate mutase family K01834,K22306 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.85,5.4.2.11 0.0000000000000000000001551 112.0
TLS2_k127_7102559_46 Acyltransferase K00655 - 2.3.1.51 0.0000000000000004054 91.0
TLS2_k127_7102559_48 Glycosyl hydrolases family 25 - - - 0.00000000000001168 89.0
TLS2_k127_7102559_49 Highly conserved protein containing a thioredoxin domain - - - 0.0000000000001502 83.0
TLS2_k127_7102559_5 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 537.0
TLS2_k127_7102559_50 - - - - 0.0000000000009006 81.0
TLS2_k127_7102559_51 HNH endonuclease K07451 - - 0.0000000000428 75.0
TLS2_k127_7102559_53 Putative zinc-finger - - - 0.00000002013 64.0
TLS2_k127_7102559_54 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000003526 53.0
TLS2_k127_7102559_55 TadE-like protein - - - 0.000003172 57.0
TLS2_k127_7102559_56 guanyl-nucleotide exchange factor activity K01183,K01190,K01224 - 3.2.1.14,3.2.1.23,3.2.1.89 0.000006047 57.0
TLS2_k127_7102559_57 - - - - 0.000006058 51.0
TLS2_k127_7102559_58 TIGRFAM helicase secretion neighborhood TadE-like protein - - - 0.00006006 55.0
TLS2_k127_7102559_59 Type II secretion system (T2SS), protein F K12511 - - 0.00006135 55.0
TLS2_k127_7102559_6 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000381 541.0
TLS2_k127_7102559_7 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008824 430.0
TLS2_k127_7102559_8 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 388.0
TLS2_k127_7102559_9 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 384.0
TLS2_k127_7209436_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 8.149e-224 704.0
TLS2_k127_7209436_1 TCP-1/cpn60 chaperonin family K04077 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679 - 2.408e-215 681.0
TLS2_k127_7209436_10 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000007951 237.0
TLS2_k127_7209436_11 - - - - 0.0000000000000000000000000000000000000000000000000000000007536 209.0
TLS2_k127_7209436_12 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000153 124.0
TLS2_k127_7209436_13 Including oxidative damage repair enzymes - - - 0.000000000000000000000000221 112.0
TLS2_k127_7209436_14 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000002176 73.0
TLS2_k127_7209436_15 Immunoglobulin-like domain of bacterial spore germination - - - 0.0000000005315 70.0
TLS2_k127_7209436_16 Transporter associated domain K03699 - - 0.0000003013 54.0
TLS2_k127_7209436_17 virulence factor - - - 0.000001119 61.0
TLS2_k127_7209436_2 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 559.0
TLS2_k127_7209436_3 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 515.0
TLS2_k127_7209436_4 COG0025 NhaP-type Na H and K H antiporters - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 448.0
TLS2_k127_7209436_5 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 433.0
TLS2_k127_7209436_6 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 435.0
TLS2_k127_7209436_7 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 349.0
TLS2_k127_7209436_8 Quinolinate phosphoribosyl transferase, C-terminal domain K00767,K03813 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 315.0
TLS2_k127_7209436_9 belongs to the nudix hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009868 294.0
TLS2_k127_7370235_0 ABC transporter, transmembrane region K02021,K06147,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005945 498.0
TLS2_k127_7370235_1 ABC transporter, transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 479.0
TLS2_k127_7370235_10 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 294.0
TLS2_k127_7370235_11 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001562 291.0
TLS2_k127_7370235_12 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000002946 239.0
TLS2_k127_7370235_13 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - 0.0000000000000000000000000000000000000000000000000000000009216 225.0
TLS2_k127_7370235_14 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000001168 207.0
TLS2_k127_7370235_15 Phosphoribosyl-AMP cyclohydrolase K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000002174 208.0
TLS2_k127_7370235_16 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000004112 211.0
TLS2_k127_7370235_17 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000008276 206.0
TLS2_k127_7370235_18 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000001133 183.0
TLS2_k127_7370235_19 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000005734 179.0
TLS2_k127_7370235_2 Putative glutamine amidotransferase K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 424.0
TLS2_k127_7370235_20 Imidazole acetol-phosphate transaminase K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000001624 182.0
TLS2_k127_7370235_21 Dihydrodipicolinate reductase, N-terminus K21672 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605 1.4.1.12,1.4.1.26 0.000000000000000000000000000000000000001043 160.0
TLS2_k127_7370235_22 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000001966 164.0
TLS2_k127_7370235_23 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000002222 119.0
TLS2_k127_7370235_24 Zn-ribbon protein, possibly nucleic acid-binding K07164 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000009062 115.0
TLS2_k127_7370235_25 - - - - 0.000000000000000002486 93.0
TLS2_k127_7370235_27 Trp repressor protein - - - 0.0000000000000000284 88.0
TLS2_k127_7370235_28 Domain of unknown function (DUF202) - - - 0.0000000000000001945 85.0
TLS2_k127_7370235_29 Redoxin - - - 0.0000000000000002347 88.0
TLS2_k127_7370235_3 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 366.0
TLS2_k127_7370235_30 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.0000000000004009 74.0
TLS2_k127_7370235_32 - - - - 0.00000000000133 73.0
TLS2_k127_7370235_33 Redoxin - - - 0.000000000001434 78.0
TLS2_k127_7370235_34 ABC-2 family transporter protein - - - 0.000000000001589 81.0
TLS2_k127_7370235_35 gamma-glutamylcyclotransferase activity K00682 GO:0001836,GO:0002376,GO:0003674,GO:0003824,GO:0003839,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007599,GO:0008150,GO:0008152,GO:0008219,GO:0008637,GO:0009058,GO:0009611,GO:0009987,GO:0012501,GO:0016043,GO:0016829,GO:0016840,GO:0016842,GO:0019184,GO:0023052,GO:0032501,GO:0034641,GO:0042060,GO:0042381,GO:0042398,GO:0042802,GO:0042803,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0045087,GO:0046983,GO:0050789,GO:0050794,GO:0050817,GO:0050878,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097190,GO:1901564,GO:1901566,GO:1901576 4.3.2.9 0.0000000001491 69.0
TLS2_k127_7370235_36 PFAM AMP-dependent synthetase and ligase - - - 0.0000000005422 73.0
TLS2_k127_7370235_37 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.00000001716 68.0
TLS2_k127_7370235_38 LysM domain - - - 0.0000002713 63.0
TLS2_k127_7370235_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013,K15509 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 355.0
TLS2_k127_7370235_5 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 350.0
TLS2_k127_7370235_6 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004262 332.0
TLS2_k127_7370235_7 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005514 316.0
TLS2_k127_7370235_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 319.0
TLS2_k127_7370235_9 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 312.0
TLS2_k127_7375301_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 4.334e-208 675.0
TLS2_k127_7375301_1 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000005745 251.0
TLS2_k127_7375301_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000002576 222.0
TLS2_k127_7375301_3 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.000000000000000000000000000000419 131.0
TLS2_k127_751729_0 Domain of unknown function (DUF3372) K01200 - 3.2.1.41 1.229e-272 863.0
TLS2_k127_751729_1 domain protein - - - 0.0000000000000000000000000000000000000000001157 171.0
TLS2_k127_819624_0 Formate nitrite K21990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000744 284.0
TLS2_k127_819624_1 metallopeptidase activity K01186,K05994 - 3.2.1.18,3.4.11.10 0.00000000000000000000000000000000000001255 156.0
TLS2_k127_819624_2 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.00000000000002026 78.0
TLS2_k127_819624_3 Cell wall hydrolase autolysin K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.00000001004 57.0
TLS2_k127_827670_0 ATP-dependent Clp protease K03696 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - 0.0 1144.0
TLS2_k127_827670_1 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 531.0
TLS2_k127_827670_10 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 367.0
TLS2_k127_827670_11 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 312.0
TLS2_k127_827670_12 ABC-type Mn2 Zn2 transport systems permease components K02075,K09819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002564 284.0
TLS2_k127_827670_13 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001289 268.0
TLS2_k127_827670_14 Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process K07067 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000001698 262.0
TLS2_k127_827670_15 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000005908 239.0
TLS2_k127_827670_16 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.000000000000000000000000000000000000000000000000000000000000003387 231.0
TLS2_k127_827670_17 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000001629 217.0
TLS2_k127_827670_18 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000005776 167.0
TLS2_k127_827670_19 Sporulation and spore germination - - - 0.0000000000000000000000000000000000000002247 167.0
TLS2_k127_827670_2 Flavin-binding monooxygenase-like K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 446.0
TLS2_k127_827670_20 AI-2E family transporter - - - 0.000000000000000000000000000000000000005089 163.0
TLS2_k127_827670_21 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000003331 154.0
TLS2_k127_827670_22 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000001123 147.0
TLS2_k127_827670_23 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000000000009567 136.0
TLS2_k127_827670_24 glyoxalase III activity - - - 0.0000000000000000000000000000000003968 137.0
TLS2_k127_827670_25 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000001274 124.0
TLS2_k127_827670_26 TIGRFAM TIGR03943 family protein - - - 0.00000000000000000000000000158 128.0
TLS2_k127_827670_27 Ferric uptake regulator family K03711 - - 0.00000000000000000000005277 104.0
TLS2_k127_827670_28 Bacterial transcriptional repressor C-terminal - - - 0.00000000000000000002557 107.0
TLS2_k127_827670_29 Belongs to the peptidase S8 family - - - 0.0000000000000000006702 97.0
TLS2_k127_827670_3 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 446.0
TLS2_k127_827670_30 Metallo-peptidase family M12 - - - 0.00000000000000001075 96.0
TLS2_k127_827670_31 Protein of unknown function (DUF3263) - - - 0.0000000000000002537 91.0
TLS2_k127_827670_32 SMART nuclease (SNase domain protein) K01174 - 3.1.31.1 0.000000000002653 77.0
TLS2_k127_827670_33 - - - - 0.00000001549 64.0
TLS2_k127_827670_34 Cysteine-rich secretory protein family - - - 0.00000003294 65.0
TLS2_k127_827670_35 - - - - 0.000000102 64.0
TLS2_k127_827670_36 RESPONSE REGULATOR receiver - - - 0.00003918 55.0
TLS2_k127_827670_37 colicin V production K03558 - - 0.0001254 53.0
TLS2_k127_827670_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 441.0
TLS2_k127_827670_5 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 386.0
TLS2_k127_827670_6 metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 397.0
TLS2_k127_827670_7 beta-1,4-mannooligosaccharide phosphorylase K20885 - 2.4.1.339,2.4.1.340 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 396.0
TLS2_k127_827670_8 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008906 383.0
TLS2_k127_827670_9 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 376.0
TLS2_k127_846643_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 8.498e-212 669.0
TLS2_k127_846643_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 6.673e-205 651.0
TLS2_k127_846643_10 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005135 275.0
TLS2_k127_846643_11 Psort location CytoplasmicMembrane, score 10.00 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009957 266.0
TLS2_k127_846643_12 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000007011 249.0
TLS2_k127_846643_13 UDP-N-acetylglucosamine 2-epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001887 247.0
TLS2_k127_846643_14 COG2148 Sugar transferases involved in lipopolysaccharide synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000004014 244.0
TLS2_k127_846643_15 Cytidylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000005653 209.0
TLS2_k127_846643_16 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.000000000000000000000000000000000000000000001272 175.0
TLS2_k127_846643_17 MOSC domain - - - 0.00000000000000000000000000000000000000002679 171.0
TLS2_k127_846643_18 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000002371 156.0
TLS2_k127_846643_2 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 616.0
TLS2_k127_846643_20 Belongs to the SUA5 family K07566 - 2.7.7.87 0.000000000000000000000000000000000001129 148.0
TLS2_k127_846643_21 Ribosomal protein L31 K02909 - - 0.000000000000000000000000000000004944 136.0
TLS2_k127_846643_23 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000006038 113.0
TLS2_k127_846643_24 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000012 108.0
TLS2_k127_846643_25 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000003046 97.0
TLS2_k127_846643_27 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000417 91.0
TLS2_k127_846643_28 Sulfotransferase domain - - - 0.000000000000006587 87.0
TLS2_k127_846643_29 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family K19429 - - 0.000000000003013 76.0
TLS2_k127_846643_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 546.0
TLS2_k127_846643_30 - - - - 0.00002673 55.0
TLS2_k127_846643_31 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 0.0005155 46.0
TLS2_k127_846643_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 533.0
TLS2_k127_846643_5 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006777 518.0
TLS2_k127_846643_6 Homoserine dehydrogenase K00003,K12524 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 413.0
TLS2_k127_846643_7 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009893 379.0
TLS2_k127_846643_8 Male sterility protein K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 380.0
TLS2_k127_846643_9 NeuB family K01654 - 2.5.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005745 289.0
TLS2_k127_878822_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 467.0
TLS2_k127_878822_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 350.0
TLS2_k127_878822_10 phosphoglycerate mutase K02226 - 3.1.3.73 0.0000000000000001663 92.0
TLS2_k127_878822_11 Guanylyl transferase CofC like K14941 - 2.7.7.68 0.0000000000001942 78.0
TLS2_k127_878822_12 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000001583 68.0
TLS2_k127_878822_13 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000003379 71.0
TLS2_k127_878822_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 329.0
TLS2_k127_878822_3 Domain of unknown function (DUF2437) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 298.0
TLS2_k127_878822_4 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000006257 222.0
TLS2_k127_878822_5 Hydroxypyruvate reductase K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000004779 199.0
TLS2_k127_878822_6 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000002074 158.0
TLS2_k127_878822_7 Belongs to the phosphoglycerate mutase family K01834,K22306 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.85,5.4.2.11 0.0000000000000000001627 102.0
TLS2_k127_878822_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000005013 100.0
TLS2_k127_878822_9 Universal stress protein family - - - 0.0000000000000001006 91.0
TLS2_k127_881252_0 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009733 353.0
TLS2_k127_881252_1 COG1879 ABC-type sugar transport system periplasmic component K02058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 344.0
TLS2_k127_881252_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 340.0
TLS2_k127_881252_3 dehydratase K03335 - 4.2.1.44 0.00000000000000000000000797 102.0
TLS2_k127_957180_0 TIGRFAM YD repeat protein - - - 1.652e-227 775.0
TLS2_k127_957180_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 439.0
TLS2_k127_957180_2 - - - - 0.00000000000000000000005068 118.0
TLS2_k127_957180_3 Integrase core domain - - - 0.00000000006976 74.0