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Overview

ID MAG04024
Name TLS2_bin.67
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Bin65
Family Bin65
Genus SBBV01
Species
Assembly information
Completeness (%) 84.32
Contamination (%) 4.71
GC content (%) 68.0
N50 (bp) 14,570
Genome size (bp) 4,587,968

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4314

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1027028_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000821 587.0
TLS2_k127_1027028_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 383.0
TLS2_k127_1027028_2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006354 329.0
TLS2_k127_1027028_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 314.0
TLS2_k127_1027028_4 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000001181 95.0
TLS2_k127_1035088_0 AcrB/AcrD/AcrF family - - - 0.0 1459.0
TLS2_k127_1035088_1 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K17218 - 1.8.5.4 1.049e-214 673.0
TLS2_k127_1035088_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 320.0
TLS2_k127_1035088_3 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009688 263.0
TLS2_k127_1035088_4 Major facilitator Superfamily K05820,K08217 - - 0.0000000000000000000000000000000000000000000000000000000000000001654 244.0
TLS2_k127_1035088_5 Protein of unknown function (DUF2892) - - - 0.00000000000000000001156 106.0
TLS2_k127_1035088_6 Major facilitator Superfamily K05820,K08217 - - 0.0000000000002369 84.0
TLS2_k127_1035088_7 Adenylate guanylate cyclase catalytic domain protein K01768 - 4.6.1.1 0.0006089 44.0
TLS2_k127_1039884_0 NAD(FAD)-dependent dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 559.0
TLS2_k127_1039884_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 458.0
TLS2_k127_1039884_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 357.0
TLS2_k127_1039884_3 Fumarylacetoacetate (FAA) hydrolase family K02509 - - 0.0000000000000000000000000000000000000000000004042 167.0
TLS2_k127_1039884_4 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000001532 98.0
TLS2_k127_1039884_5 radical SAM domain protein - - - 0.000000000000001916 90.0
TLS2_k127_1046750_0 Aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005368 487.0
TLS2_k127_1046750_1 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 361.0
TLS2_k127_1046750_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000001679 67.0
TLS2_k127_1046750_2 Bile acid sodium symporter K14347 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 293.0
TLS2_k127_1046750_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002577 278.0
TLS2_k127_1046750_4 aspartate racemase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001066 277.0
TLS2_k127_1046750_5 Cell Wall Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004537 249.0
TLS2_k127_1046750_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000001953 221.0
TLS2_k127_1046750_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000005323 216.0
TLS2_k127_1046750_8 AntiSigma factor - - - 0.00000000000000000000000000000000000000000004124 173.0
TLS2_k127_1046750_9 - - - - 0.000000000000000000000000000000001078 141.0
TLS2_k127_1055290_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.318e-234 736.0
TLS2_k127_1055290_1 Amidohydrolase family K01464 - 3.5.2.2 1.443e-212 673.0
TLS2_k127_1055290_10 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 319.0
TLS2_k127_1055290_11 isomerase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 307.0
TLS2_k127_1055290_12 Phenazine biosynthesis-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 299.0
TLS2_k127_1055290_13 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001704 280.0
TLS2_k127_1055290_14 LysR substrate binding domain K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000008327 245.0
TLS2_k127_1055290_15 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000003261 205.0
TLS2_k127_1055290_16 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000512 188.0
TLS2_k127_1055290_17 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000000000000000005562 176.0
TLS2_k127_1055290_18 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000003147 167.0
TLS2_k127_1055290_19 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000003464 176.0
TLS2_k127_1055290_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005332 597.0
TLS2_k127_1055290_20 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000000000001649 151.0
TLS2_k127_1055290_21 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000003316 153.0
TLS2_k127_1055290_22 protein possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000002037 139.0
TLS2_k127_1055290_23 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000006633 132.0
TLS2_k127_1055290_24 transport - - - 0.00000000000001166 83.0
TLS2_k127_1055290_25 Domain of unknown function (DUF1127) - - - 0.0000000004006 64.0
TLS2_k127_1055290_26 transport - - - 0.000000003143 67.0
TLS2_k127_1055290_27 PFAM Pentapeptide repeats (8 copies) - - - 0.00000004635 65.0
TLS2_k127_1055290_3 Isocitrate/isopropylmalate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 527.0
TLS2_k127_1055290_4 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 508.0
TLS2_k127_1055290_5 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009382 412.0
TLS2_k127_1055290_6 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 397.0
TLS2_k127_1055290_7 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 398.0
TLS2_k127_1055290_8 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 331.0
TLS2_k127_1055290_9 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 312.0
TLS2_k127_1088101_0 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 479.0
TLS2_k127_1088101_1 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000887 281.0
TLS2_k127_1088101_2 Belongs to the hyi family K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000004135 258.0
TLS2_k127_1088101_3 - - - - 0.000000000004582 76.0
TLS2_k127_1089797_0 Glutathionylspermidine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 494.0
TLS2_k127_1089797_1 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001808 276.0
TLS2_k127_1089797_2 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001455 268.0
TLS2_k127_1089797_3 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001884 269.0
TLS2_k127_1089797_4 MarR family - - - 0.00000000000000000000000000000000000000000000000000000000000000006944 226.0
TLS2_k127_1089797_5 Protein of unknown function, DUF393 - - - 0.000000000000000000000000000000001949 133.0
TLS2_k127_1089797_6 Protein of unknown function, DUF393 - - - 0.00000000000000001425 89.0
TLS2_k127_1089797_7 Protein of unknown function, DUF393 - - - 0.0002792 51.0
TLS2_k127_1102217_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1212.0
TLS2_k127_1102217_1 Hydantoinase/oxoprolinase - - - 5.13e-296 923.0
TLS2_k127_1102217_10 FAD dependent oxidoreductase K00273 - 1.4.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 331.0
TLS2_k127_1102217_11 alcohol dehydrogenase K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 311.0
TLS2_k127_1102217_12 CO dehydrogenase flavoprotein C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007586 311.0
TLS2_k127_1102217_13 Amino acid synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000142 293.0
TLS2_k127_1102217_14 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000001874 252.0
TLS2_k127_1102217_15 transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002635 252.0
TLS2_k127_1102217_16 Domain of unknown function (DUF4439) - - - 0.00000000000000000000000000000000000000000000000000000000000000001869 234.0
TLS2_k127_1102217_17 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000000000000000000000000000000001497 219.0
TLS2_k127_1102217_18 Pfam:DUF2029 K13669 - - 0.00000000000000000000000000000000000000000000000000000003871 214.0
TLS2_k127_1102217_19 PFAM Glycosyl transferase family 2 K00721,K20534 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000005093 209.0
TLS2_k127_1102217_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.486e-280 871.0
TLS2_k127_1102217_20 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000005233 190.0
TLS2_k127_1102217_21 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000000002012 183.0
TLS2_k127_1102217_22 Protein of unknown function (DUF3775) - - - 0.0000000000000000000000000000000000000008034 151.0
TLS2_k127_1102217_23 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000003611 149.0
TLS2_k127_1102217_24 Cytochrome c - - - 0.000000000000000000000000002503 125.0
TLS2_k127_1102217_25 PilZ domain - - - 0.00007521 51.0
TLS2_k127_1102217_26 PilZ domain - - - 0.0002382 50.0
TLS2_k127_1102217_3 Hydantoinase B/oxoprolinase - - - 2.371e-275 857.0
TLS2_k127_1102217_4 COG1180 Pyruvate-formate lyase-activating enzyme - - - 4.547e-232 728.0
TLS2_k127_1102217_5 Branched-chain amino acid transport system / permease component K01997,K01998 - - 1.663e-197 636.0
TLS2_k127_1102217_6 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 511.0
TLS2_k127_1102217_7 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 348.0
TLS2_k127_1102217_8 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 351.0
TLS2_k127_1102217_9 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006932 336.0
TLS2_k127_1123219_0 catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP K00647 - 2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 547.0
TLS2_k127_1123219_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 352.0
TLS2_k127_1123219_2 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001423 278.0
TLS2_k127_1123219_3 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000002926 236.0
TLS2_k127_1123219_4 Fatty acid desaturase K00496 - 1.14.15.3 0.000000000000000000000000000000000000000000000000000000000000000003318 238.0
TLS2_k127_1123219_5 lipid kinase activity - - - 0.0000000000000000000000000000000000000000000000000001939 204.0
TLS2_k127_1123219_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000003722 180.0
TLS2_k127_1160140_0 Amidase - - - 2.562e-253 794.0
TLS2_k127_1160140_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 489.0
TLS2_k127_1160140_10 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.0000000000000000000000000292 125.0
TLS2_k127_1160140_11 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.00000000000000000000000003656 115.0
TLS2_k127_1160140_12 Alpha beta hydrolase - - - 0.000000000000000000000002025 115.0
TLS2_k127_1160140_13 Transcriptional regulator - - - 0.000000000000000000001316 104.0
TLS2_k127_1160140_14 Belongs to the 'phage' integrase family - - - 0.00000000000000000001111 97.0
TLS2_k127_1160140_15 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00000000000005362 72.0
TLS2_k127_1160140_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 349.0
TLS2_k127_1160140_3 Belongs to the binding-protein-dependent transport system permease family K01998,K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 361.0
TLS2_k127_1160140_4 Belongs to the binding-protein-dependent transport system permease family K01997,K11960 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009328 349.0
TLS2_k127_1160140_5 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 344.0
TLS2_k127_1160140_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001042 289.0
TLS2_k127_1160140_7 ATPases associated with a variety of cellular activities K01995,K11962 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002396 287.0
TLS2_k127_1160140_8 ATPases associated with a variety of cellular activities K01996,K11963 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002083 252.0
TLS2_k127_1160140_9 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000005038 214.0
TLS2_k127_1174906_0 Berberine and berberine like - - - 4.016e-263 822.0
TLS2_k127_1174906_1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000003389 151.0
TLS2_k127_1174906_2 Peptidase C13 family - - - 0.000000000000000000000000000000000004011 147.0
TLS2_k127_1174906_3 transcriptional regulator, MerR - - - 0.000000000000000000000000000003441 133.0
TLS2_k127_1174906_4 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.0000000000008448 68.0
TLS2_k127_1186939_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 8.511e-244 766.0
TLS2_k127_1186939_1 LVIVD repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 434.0
TLS2_k127_1186939_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 325.0
TLS2_k127_1186939_3 PFAM ABC transporter related K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 308.0
TLS2_k127_1186939_4 protein conserved in bacteria K09938 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001864 263.0
TLS2_k127_1186939_5 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001419 245.0
TLS2_k127_1186939_6 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000002945 244.0
TLS2_k127_1186939_7 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000002959 241.0
TLS2_k127_1186939_8 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000006531 216.0
TLS2_k127_1186939_9 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000219 207.0
TLS2_k127_1214342_0 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K07303 - 1.3.99.16 3.961e-245 777.0
TLS2_k127_1214342_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006822 400.0
TLS2_k127_1214342_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 404.0
TLS2_k127_1214342_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 359.0
TLS2_k127_1214342_4 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008047 322.0
TLS2_k127_1214342_5 [2Fe-2S] binding domain K00256,K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000001833 258.0
TLS2_k127_1214342_6 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000006489 252.0
TLS2_k127_1214342_7 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000004963 223.0
TLS2_k127_1214342_8 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000253 217.0
TLS2_k127_1214342_9 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000001597 68.0
TLS2_k127_121856_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 5.494e-223 715.0
TLS2_k127_121856_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 612.0
TLS2_k127_121856_2 NADPH quinone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 304.0
TLS2_k127_121856_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000002047 234.0
TLS2_k127_1218738_0 Male sterility protein K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 536.0
TLS2_k127_1218738_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 451.0
TLS2_k127_1218738_10 SIS domain K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 290.0
TLS2_k127_1218738_11 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000000000002013 241.0
TLS2_k127_1218738_12 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000001431 239.0
TLS2_k127_1218738_13 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000002501 237.0
TLS2_k127_1218738_14 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000002177 227.0
TLS2_k127_1218738_15 Polynucleotide kinase 3 phosphatase K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000003379 214.0
TLS2_k127_1218738_16 Polynucleotide kinase 3 phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000000000001302 189.0
TLS2_k127_1218738_17 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000008768 167.0
TLS2_k127_1218738_18 ADP-glyceromanno-heptose 6-epimerase activity K00091,K22320 - 1.1.1.219,1.1.1.412 0.000000000000000000000000002179 122.0
TLS2_k127_1218738_19 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000000000000143 113.0
TLS2_k127_1218738_2 PFAM NAD dependent epimerase dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 443.0
TLS2_k127_1218738_20 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000001468 72.0
TLS2_k127_1218738_21 Tetratricopeptide repeat - - - 0.00000003113 55.0
TLS2_k127_1218738_3 Belongs to the DegT DnrJ EryC1 family K12452 - 1.17.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 420.0
TLS2_k127_1218738_4 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008655 383.0
TLS2_k127_1218738_5 GHMP kinases C terminal K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007612 376.0
TLS2_k127_1218738_6 Dehydrogenase E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 361.0
TLS2_k127_1218738_7 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K00066 GO:0000271,GO:0003674,GO:0003824,GO:0003979,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576 1.1.1.132,1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 340.0
TLS2_k127_1218738_8 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 315.0
TLS2_k127_1218738_9 Transaldolase K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 299.0
TLS2_k127_1269981_0 pilus assembly protein ATPase CpaF K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 589.0
TLS2_k127_1269981_1 Belongs to the GSP D family K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001079 272.0
TLS2_k127_1269981_2 pilus assembly protein TadB K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005186 249.0
TLS2_k127_1269981_3 type II secretion system protein K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009562 247.0
TLS2_k127_1269981_4 Flp pilus assembly protein, ATPase CpaE K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000008144 256.0
TLS2_k127_1269981_5 peptidyl-tyrosine sulfation - - - 0.00000000000004363 84.0
TLS2_k127_1269981_6 Pilus biogenesis CpaD protein (pilus_cpaD) K02281 - - 0.000000002604 67.0
TLS2_k127_1303207_0 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 597.0
TLS2_k127_1303207_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 591.0
TLS2_k127_1303207_2 PAS PAC sensor protein K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 544.0
TLS2_k127_1303207_3 Belongs to the CarB family K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 381.0
TLS2_k127_1303207_4 response regulator receiver - - - 0.000000000000000000000000000000000000000000000001766 177.0
TLS2_k127_1303207_5 Ankyrin repeat - - - 0.000000000000000000000000001944 126.0
TLS2_k127_1303207_6 - - - - 0.000000000002233 76.0
TLS2_k127_1303207_7 - - - - 0.0000001476 60.0
TLS2_k127_1303207_8 Putative peptidoglycan binding domain - - - 0.00004615 56.0
TLS2_k127_1309352_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 351.0
TLS2_k127_1309352_1 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 301.0
TLS2_k127_1309352_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000003272 249.0
TLS2_k127_1309352_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000004455 231.0
TLS2_k127_1309352_4 2-oxohepta-3-ene-1,7-dioic acid hydratase K02509,K02554 - 4.2.1.80 0.00000000000000000000000000000003018 137.0
TLS2_k127_1309352_5 Conserved protein containing a Zn-ribbon-like motif possibly RNA-binding - - - 0.000000000000000000001022 97.0
TLS2_k127_1309352_6 PIN domain - - - 0.00000000000000001636 88.0
TLS2_k127_1328221_0 Tripartite tricarboxylate transporter TctA family - - - 1.645e-208 659.0
TLS2_k127_1328221_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 2.944e-203 646.0
TLS2_k127_1328221_10 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000002972 141.0
TLS2_k127_1328221_11 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000005555 138.0
TLS2_k127_1328221_12 - - - - 0.0000000000000000000000008304 116.0
TLS2_k127_1328221_13 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000005709 85.0
TLS2_k127_1328221_2 FAD dependent oxidoreductase K00244 - 1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 589.0
TLS2_k127_1328221_3 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 519.0
TLS2_k127_1328221_4 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 306.0
TLS2_k127_1328221_5 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000009146 228.0
TLS2_k127_1328221_6 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000505 232.0
TLS2_k127_1328221_7 aspartate dehydrogenase activity K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000003138 170.0
TLS2_k127_1328221_8 Cysteine dioxygenase type I - - - 0.00000000000000000000000000000000000004534 150.0
TLS2_k127_1328221_9 Hydrolase - - - 0.0000000000000000000000000000000000001824 151.0
TLS2_k127_1358213_0 belongs to the aldehyde dehydrogenase family K00128,K00130 - 1.2.1.3,1.2.1.8 1.258e-209 661.0
TLS2_k127_1358213_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 619.0
TLS2_k127_1358213_10 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000001394 131.0
TLS2_k127_1358213_11 - - - - 0.00000000004596 69.0
TLS2_k127_1358213_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008735 325.0
TLS2_k127_1358213_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K10617 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 301.0
TLS2_k127_1358213_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 309.0
TLS2_k127_1358213_5 Bacterial transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007419 263.0
TLS2_k127_1358213_6 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000008145 248.0
TLS2_k127_1358213_7 BON domain - - - 0.00000000000000000000000000000000000000000000000000000000002653 213.0
TLS2_k127_1358213_8 Alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000008299 207.0
TLS2_k127_1358213_9 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000001585 138.0
TLS2_k127_136274_0 DEAD/H associated K03724 - - 0.0 1038.0
TLS2_k127_136274_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 8.726e-295 918.0
TLS2_k127_136274_10 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008976 250.0
TLS2_k127_136274_11 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000002791 244.0
TLS2_k127_136274_12 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000005036 225.0
TLS2_k127_136274_13 Calcineurin-like phosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000003985 242.0
TLS2_k127_136274_14 protein conserved in bacteria K09984 - - 0.00000000000000000000000000000000002908 135.0
TLS2_k127_136274_15 CBS domain - - - 0.000000000000000000000000000000003166 135.0
TLS2_k127_136274_16 Cold shock K03704 - - 0.00000000000000000000001073 101.0
TLS2_k127_136274_17 BON domain - - - 0.000000000000000003211 87.0
TLS2_k127_136274_18 Protein of unknown function (DUF3592) - - - 0.00000008931 60.0
TLS2_k127_136274_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 1.819e-206 649.0
TLS2_k127_136274_3 DNA ligase N terminus K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 2.204e-206 673.0
TLS2_k127_136274_4 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004826 522.0
TLS2_k127_136274_5 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 479.0
TLS2_k127_136274_6 Sodium/hydrogen exchanger family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005338 428.0
TLS2_k127_136274_7 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 294.0
TLS2_k127_136274_8 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005679 269.0
TLS2_k127_136274_9 penicillin-insensitive murein endopeptidase K07261 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004422 254.0
TLS2_k127_1366907_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 8.778e-249 781.0
TLS2_k127_1366907_1 Integrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 495.0
TLS2_k127_1366907_10 PFAM Glycosyl transferase family 2 K21349 - 2.4.1.268 0.000000000000000000000001727 121.0
TLS2_k127_1366907_11 glycosyl transferase group 1 K16150 - 2.4.1.11 0.00000000001791 77.0
TLS2_k127_1366907_2 Peptidase M16 inactive domain K07263,K07623 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 408.0
TLS2_k127_1366907_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 407.0
TLS2_k127_1366907_4 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 393.0
TLS2_k127_1366907_5 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 340.0
TLS2_k127_1366907_6 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001445 248.0
TLS2_k127_1366907_7 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K01487,K11991 - 3.5.4.1,3.5.4.3,3.5.4.33 0.000000000000000000000000000000000000000000000000000000000006522 211.0
TLS2_k127_1366907_8 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000001033 207.0
TLS2_k127_1366907_9 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000000000002864 194.0
TLS2_k127_1367401_0 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 396.0
TLS2_k127_1367401_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001256 264.0
TLS2_k127_1367401_2 Tetratricopeptide repeat - - - 0.00000000000001282 81.0
TLS2_k127_1367401_3 Belongs to the 'phage' integrase family - - - 0.00000000001248 69.0
TLS2_k127_1390450_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 566.0
TLS2_k127_1390450_1 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 473.0
TLS2_k127_1390450_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000002744 249.0
TLS2_k127_1390450_11 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000001163 227.0
TLS2_k127_1390450_12 PFAM short chain dehydrogenase K00046,K00216 - 1.1.1.69,1.3.1.28 0.00000000000000000000000000000000000000000000000000000000000811 216.0
TLS2_k127_1390450_13 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000005183 212.0
TLS2_k127_1390450_14 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.00000000000000000000000000000000000000000000000288 188.0
TLS2_k127_1390450_15 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000005968 179.0
TLS2_k127_1390450_16 helix_turn_helix, cAMP Regulatory protein K01420,K15861 - - 0.000000000000000000000000000000000000000002097 165.0
TLS2_k127_1390450_17 Ring hydroxylating subunit beta family protein 1 - - - 0.00000000000000000000000000137 127.0
TLS2_k127_1390450_18 helix_turn_helix, Lux Regulon K14987 - - 0.0000000000000000000002274 103.0
TLS2_k127_1390450_19 transcriptional regulator - - - 0.000000000000000003538 91.0
TLS2_k127_1390450_2 Rieske 2Fe-2S domain protein K14748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 436.0
TLS2_k127_1390450_20 Sugar-specific transcriptional regulator TrmB - - - 0.00000000004718 70.0
TLS2_k127_1390450_21 Protein of unknown function (DUF2849) - - - 0.0000001959 64.0
TLS2_k127_1390450_3 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 386.0
TLS2_k127_1390450_4 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009669 362.0
TLS2_k127_1390450_5 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 344.0
TLS2_k127_1390450_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000948 325.0
TLS2_k127_1390450_7 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 312.0
TLS2_k127_1390450_8 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001476 291.0
TLS2_k127_1390450_9 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005735 282.0
TLS2_k127_140618_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 8.35e-322 992.0
TLS2_k127_140618_1 PFAM peptidase S9A prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 3.721e-241 764.0
TLS2_k127_140618_10 Transcriptional K03892 - - 0.0000000000000000000000000000008734 127.0
TLS2_k127_140618_11 - - - - 0.0000000000000009291 84.0
TLS2_k127_140618_12 AAA domain - - - 0.00000004844 62.0
TLS2_k127_140618_2 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 539.0
TLS2_k127_140618_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 544.0
TLS2_k127_140618_4 Fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 319.0
TLS2_k127_140618_5 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 306.0
TLS2_k127_140618_6 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000203 271.0
TLS2_k127_140618_7 Sugar (and other) transporter K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002234 283.0
TLS2_k127_140618_8 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000000000000000000000000000000000000000000000000000000000003082 219.0
TLS2_k127_140618_9 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000003056 166.0
TLS2_k127_1421161_0 - - - - 1.269e-260 817.0
TLS2_k127_1421161_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 507.0
TLS2_k127_1421161_10 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000000000000000000000000000007033 235.0
TLS2_k127_1421161_11 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000006998 205.0
TLS2_k127_1421161_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993 - - 0.000000000000000000000000000000000000000000000000346 186.0
TLS2_k127_1421161_13 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000134 94.0
TLS2_k127_1421161_14 ANTAR K22010 GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 - 0.000000000000001473 85.0
TLS2_k127_1421161_2 Cysteine-rich domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 489.0
TLS2_k127_1421161_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 485.0
TLS2_k127_1421161_4 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 469.0
TLS2_k127_1421161_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 436.0
TLS2_k127_1421161_6 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 397.0
TLS2_k127_1421161_7 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008023 395.0
TLS2_k127_1421161_8 Mitochondrial fission ELM1 K07276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 310.0
TLS2_k127_1421161_9 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002641 249.0
TLS2_k127_1421328_0 AMP-binding enzyme K01897 - 6.2.1.3 4.181e-196 628.0
TLS2_k127_1421328_1 oligoendopeptidase F K08602 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 406.0
TLS2_k127_1421328_2 Porin subfamily - - - 0.0000000000000000000000001961 121.0
TLS2_k127_1430409_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 377.0
TLS2_k127_1430409_1 Protein of unknown function (DUF3754) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 388.0
TLS2_k127_1430409_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 303.0
TLS2_k127_1430409_3 Acyl-CoA dehydrogenase, C-terminal domain K20942 - 1.14.14.27 0.000000000000000000000000000000000000000000000000000000009368 206.0
TLS2_k127_1430409_4 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000001562 170.0
TLS2_k127_1430409_5 - - - - 0.00000009817 57.0
TLS2_k127_1430409_6 Forkhead associated domain K01990,K21397 - - 0.0000006085 55.0
TLS2_k127_1434261_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1296.0
TLS2_k127_1434261_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 1.064e-249 790.0
TLS2_k127_1434261_2 glycyl-tRNA synthetase, alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 505.0
TLS2_k127_146033_0 Belongs to the thiolase family K00626 - 2.3.1.9 2.943e-199 626.0
TLS2_k127_146033_1 Acyl-CoA dehydrogenase, C-terminal domain K00253 - 1.3.8.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 507.0
TLS2_k127_146033_2 formamidase K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 460.0
TLS2_k127_146033_3 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 306.0
TLS2_k127_146033_4 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000001459 178.0
TLS2_k127_1518210_0 PEP-utilising enzyme, TIM barrel domain K01007 - 2.7.9.2 0.0 1183.0
TLS2_k127_1518210_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 2.305e-245 768.0
TLS2_k127_1518210_10 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000000000000000001242 239.0
TLS2_k127_1518210_11 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000009853 236.0
TLS2_k127_1518210_12 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - 0.000000000000000000000000000000000000000000000000000000000003688 220.0
TLS2_k127_1518210_13 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000001238 222.0
TLS2_k127_1518210_14 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000001458 175.0
TLS2_k127_1518210_15 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000002167 120.0
TLS2_k127_1518210_16 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000008733 111.0
TLS2_k127_1518210_17 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000000000000003552 113.0
TLS2_k127_1518210_18 Domain of unknown function (DU1801) - - - 0.0000000000000000004999 92.0
TLS2_k127_1518210_19 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000002053 82.0
TLS2_k127_1518210_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 5.514e-237 769.0
TLS2_k127_1518210_20 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000001646 75.0
TLS2_k127_1518210_21 - - - - 0.0000000003843 64.0
TLS2_k127_1518210_3 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 576.0
TLS2_k127_1518210_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 462.0
TLS2_k127_1518210_5 Signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 389.0
TLS2_k127_1518210_6 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004971 323.0
TLS2_k127_1518210_7 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 314.0
TLS2_k127_1518210_8 Acts on guanine, xanthine and to a lesser extent hypoxanthine K00769 - 2.4.2.22 0.0000000000000000000000000000000000000000000000000000000000000000000002538 242.0
TLS2_k127_1518210_9 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000722 254.0
TLS2_k127_1527469_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 6.42e-200 632.0
TLS2_k127_1527469_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008032 477.0
TLS2_k127_1527469_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 391.0
TLS2_k127_1527469_3 Spermidine putrescine-binding periplasmic protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 386.0
TLS2_k127_1527469_4 FMN-dependent alpha-hydroxy acid dehydrogenase K00101 - 1.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 377.0
TLS2_k127_1527469_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 356.0
TLS2_k127_1527469_6 Binding-protein-dependent transport system inner membrane component K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 300.0
TLS2_k127_1527469_7 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001034 287.0
TLS2_k127_1527469_8 - - - - 0.0000000000000000000000000000000000000000001712 171.0
TLS2_k127_153253_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1189.0
TLS2_k127_153253_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 3.616e-292 904.0
TLS2_k127_153253_10 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K02029,K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 451.0
TLS2_k127_153253_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase K00446 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 414.0
TLS2_k127_153253_12 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 351.0
TLS2_k127_153253_13 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 337.0
TLS2_k127_153253_14 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 350.0
TLS2_k127_153253_15 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 297.0
TLS2_k127_153253_16 permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 292.0
TLS2_k127_153253_17 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001954 280.0
TLS2_k127_153253_18 COG2518 Protein-L-isoaspartate carboxylmethyltransferase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000002322 237.0
TLS2_k127_153253_19 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.0000000000000000000000000000000000000000000000000000000000000000006264 233.0
TLS2_k127_153253_2 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 1.317e-224 702.0
TLS2_k127_153253_20 COG1145 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000007789 224.0
TLS2_k127_153253_21 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000009081 219.0
TLS2_k127_153253_22 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000008079 221.0
TLS2_k127_153253_23 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000005666 196.0
TLS2_k127_153253_24 response to abiotic stimulus K06867 GO:0008150,GO:0009314,GO:0009628,GO:0050896 - 0.0000000000000000000000000000000000000000000000000005319 204.0
TLS2_k127_153253_25 Sel1-like repeats. K07126 - - 0.000000000000000000000000000001378 135.0
TLS2_k127_153253_26 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.0000000000000000000000000002249 116.0
TLS2_k127_153253_27 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000001316 116.0
TLS2_k127_153253_28 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000014 117.0
TLS2_k127_153253_29 Cytochrome C556 - - - 0.0000000000000006411 85.0
TLS2_k127_153253_3 PFAM Glycosyl transferase family 2 K03669 - - 1.887e-208 675.0
TLS2_k127_153253_30 positive regulation of growth - - - 0.00000000000004984 74.0
TLS2_k127_153253_31 PAS domain - - - 0.00000000003054 76.0
TLS2_k127_153253_32 Protein of unknown function (DUF1348) - - - 0.00000000006096 69.0
TLS2_k127_153253_33 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000068 68.0
TLS2_k127_153253_34 Small subunit K07474 - - 0.000001106 60.0
TLS2_k127_153253_35 Protein of unknown function (DUF2497) K09991 - - 0.00006978 55.0
TLS2_k127_153253_4 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 612.0
TLS2_k127_153253_5 protein conserved in bacteria K09989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000937 576.0
TLS2_k127_153253_6 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 589.0
TLS2_k127_153253_7 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 520.0
TLS2_k127_153253_8 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 498.0
TLS2_k127_153253_9 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 473.0
TLS2_k127_156975_0 Transglutaminase/protease-like homologues - - - 0.0 1488.0
TLS2_k127_156975_1 Circularly permuted ATP-grasp type 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 598.0
TLS2_k127_156975_2 Belongs to the DapB family K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 299.0
TLS2_k127_156975_3 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001104 288.0
TLS2_k127_156975_4 response to abiotic stimulus K06867 - - 0.0000000000000000000000000000000000000000000000000000000000001297 219.0
TLS2_k127_156975_5 Aminoacyl-tRNA editing domain - - - 0.000000000000000000000000000000000000000000000000000000007981 206.0
TLS2_k127_1661217_0 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000581 455.0
TLS2_k127_1661217_1 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 416.0
TLS2_k127_1661217_10 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03790,K22278 - 2.3.1.128,3.5.1.104 0.00000000000000000000000000000002772 138.0
TLS2_k127_1661217_11 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000003793 131.0
TLS2_k127_1661217_12 Aldo/keto reductase family - - - 0.00000000000000000000000005633 124.0
TLS2_k127_1661217_13 COG0367 Asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000002556 122.0
TLS2_k127_1661217_14 - - - - 0.000000000000000000001521 102.0
TLS2_k127_1661217_15 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00003602 55.0
TLS2_k127_1661217_2 Bacterial transferase hexapeptide (six repeats) K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 350.0
TLS2_k127_1661217_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009706 340.0
TLS2_k127_1661217_4 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648,K22317 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000127 291.0
TLS2_k127_1661217_5 Bacterial transferase hexapeptide (six repeats) K13018 - 2.3.1.201 0.00000000000000000000000000000000000000000000000000000000000000000001088 251.0
TLS2_k127_1661217_6 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000005546 230.0
TLS2_k127_1661217_7 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000001953 221.0
TLS2_k127_1661217_8 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000644 185.0
TLS2_k127_1661217_9 AsmA family K07289 - - 0.00000000000000000000000000000001681 131.0
TLS2_k127_1703611_0 Polysaccharide biosynthesis protein K13013,K15894 - 4.2.1.115 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 377.0
TLS2_k127_1703611_1 PFAM ABC transporter related K06148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 316.0
TLS2_k127_1703611_2 Nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000001638 233.0
TLS2_k127_1703611_3 Cytidylyltransferase - - - 0.000000000000000000000000000000000001388 149.0
TLS2_k127_1723046_0 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001846 297.0
TLS2_k127_1723046_1 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002655 277.0
TLS2_k127_1723046_2 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000134 273.0
TLS2_k127_1723046_3 carbonic anhydrase K01674 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000003988 239.0
TLS2_k127_1723046_4 COG3106 Predicted ATPase K06918 - - 0.0000000000000000000000000000000000000000000000000000000000000000307 242.0
TLS2_k127_1723046_5 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.00000000000000000000000000000000000000000000000000003497 198.0
TLS2_k127_1723046_6 membrane - - - 0.00000000000000000000000000000000004882 141.0
TLS2_k127_1737499_0 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 4.054e-205 653.0
TLS2_k127_1737499_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 467.0
TLS2_k127_1737499_2 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 419.0
TLS2_k127_1737499_3 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 341.0
TLS2_k127_1737499_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000004738 250.0
TLS2_k127_1737499_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004753 240.0
TLS2_k127_1737499_6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000001372 226.0
TLS2_k127_1737499_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000004944 149.0
TLS2_k127_1737499_8 SnoaL-like polyketide cyclase K15945 - - 0.00000000001408 70.0
TLS2_k127_175564_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 610.0
TLS2_k127_175564_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 515.0
TLS2_k127_175564_2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000003113 232.0
TLS2_k127_175564_3 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000003458 229.0
TLS2_k127_175564_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000003764 167.0
TLS2_k127_175564_5 - - - - 0.000000000000000000000000000000001441 134.0
TLS2_k127_175564_6 transposase activity - - - 0.00000000000001654 72.0
TLS2_k127_175564_7 - - - - 0.0003952 53.0
TLS2_k127_1772137_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 1255.0
TLS2_k127_1772137_1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 9.114e-235 734.0
TLS2_k127_1772137_2 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 327.0
TLS2_k127_1772137_3 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004589 298.0
TLS2_k127_1807304_0 Aerotolerance regulator N-terminal - - - 2.889e-281 892.0
TLS2_k127_1807304_1 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 547.0
TLS2_k127_1807304_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 507.0
TLS2_k127_1807304_3 poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 403.0
TLS2_k127_1807304_4 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 338.0
TLS2_k127_1807304_5 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 292.0
TLS2_k127_1807304_6 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000004706 226.0
TLS2_k127_1807304_7 Protein of unknown function (DUF1285) K09986 - - 0.000000000000000000000000000000000000000000000000000000003253 222.0
TLS2_k127_1836822_0 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K13584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 416.0
TLS2_k127_1836822_1 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 417.0
TLS2_k127_1836822_10 helix_turn_helix, Lux Regulon - - - 0.0000001773 63.0
TLS2_k127_1836822_2 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 350.0
TLS2_k127_1836822_3 SNARE associated Golgi protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 328.0
TLS2_k127_1836822_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 312.0
TLS2_k127_1836822_5 Phosphorylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 323.0
TLS2_k127_1836822_6 DsrE/DsrF-like family K06039 - - 0.0000000000000000000000000000000000000000000000000001008 192.0
TLS2_k127_1836822_7 Haem-degrading - - - 0.0000000000000000000000000000000000000000002917 174.0
TLS2_k127_1836822_8 Protein of unknown function (DUF1153) - - - 0.000000000000000000000000000000000012 139.0
TLS2_k127_1836822_9 Histidine phosphotransferase C-terminal domain K13588 - - 0.00000000001301 68.0
TLS2_k127_187388_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 412.0
TLS2_k127_187388_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000858 419.0
TLS2_k127_187388_2 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 374.0
TLS2_k127_187388_3 Biotin/lipoate A/B protein ligase family - - - 0.000000000000000000000000000000000000003025 156.0
TLS2_k127_187388_4 - - - - 0.000000000000000000000000000000000000006271 155.0
TLS2_k127_187388_5 tetR family' - - - 0.0000000000000000000000000000000001043 139.0
TLS2_k127_187388_6 GGDEF domain K13590 - 2.7.7.65 0.000008939 58.0
TLS2_k127_1898838_0 transport system fused permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 579.0
TLS2_k127_1898838_1 TRAP transporter solute receptor TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 471.0
TLS2_k127_1898838_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 474.0
TLS2_k127_1898838_3 Prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 370.0
TLS2_k127_1898838_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004958 279.0
TLS2_k127_1898838_5 Phenylacetate-CoA oxygenase K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000001971 211.0
TLS2_k127_1898838_6 chorismate mutase - - - 0.0000000000000000003589 97.0
TLS2_k127_1903140_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007672 572.0
TLS2_k127_1903140_1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 385.0
TLS2_k127_1903140_2 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 372.0
TLS2_k127_1903140_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 368.0
TLS2_k127_1903140_4 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 308.0
TLS2_k127_1903140_5 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.000000000000000000000000000000000000000000003783 176.0
TLS2_k127_1934914_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009963 439.0
TLS2_k127_1934914_1 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 417.0
TLS2_k127_1934914_2 branched-chain amino acid K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 302.0
TLS2_k127_1934914_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000005652 188.0
TLS2_k127_1951143_0 Fumarylacetoacetate (FAA) hydrolase family K02509 - - 0.0000000000000000000000000000000000000000000000000000000000000002207 227.0
TLS2_k127_1951143_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000003063 201.0
TLS2_k127_1951143_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000002313 154.0
TLS2_k127_1951143_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000002346 151.0
TLS2_k127_1951143_4 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.0007497 46.0
TLS2_k127_1971394_0 NeuB family K01654 - 2.5.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 304.0
TLS2_k127_1971394_1 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001269 287.0
TLS2_k127_1971394_2 symbiont process K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000566 237.0
TLS2_k127_1971394_3 UDP-N-acetylglucosamine 2-epimerase activity K01791,K18429 GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016787,GO:0016798,GO:0044238,GO:0071704,GO:1901576 3.2.1.184,5.1.3.14 0.00000000000000000000000000000000000000000000000005463 202.0
TLS2_k127_1971394_4 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family - - - 0.0000000000000000000005689 108.0
TLS2_k127_1971394_5 capsule polysaccharide - - - 0.00000000000007666 85.0
TLS2_k127_1987962_0 Bacterial protein of unknown function (DUF839) K07093 - - 1.957e-231 734.0
TLS2_k127_1987962_1 Bacterial protein of unknown function (DUF839) K07093 - - 6.322e-214 684.0
TLS2_k127_1987962_2 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 524.0
TLS2_k127_1987962_3 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 316.0
TLS2_k127_1987962_4 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000002835 258.0
TLS2_k127_1987962_5 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000004389 188.0
TLS2_k127_1987962_6 DNA repair protein MmcB-like - - - 0.000000000000000000000000000000000000002775 154.0
TLS2_k127_1987962_7 protein, Hemolysin III K11068 - - 0.00000000000000000000000000000194 136.0
TLS2_k127_1988563_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 7.923e-286 904.0
TLS2_k127_1988563_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.553e-259 810.0
TLS2_k127_1988563_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 353.0
TLS2_k127_1988563_3 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000000005769 141.0
TLS2_k127_1988563_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000008493 133.0
TLS2_k127_1988563_5 Protein of unknown function (DUF448) K07742 - - 0.00000000000000000002422 96.0
TLS2_k127_1992925_0 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008273 564.0
TLS2_k127_1992925_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 475.0
TLS2_k127_1992925_2 Carbon-nitrogen hydrolase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 349.0
TLS2_k127_1992925_3 TRAP transporter solute receptor TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 344.0
TLS2_k127_1992925_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003486 253.0
TLS2_k127_1992925_5 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000000000000000000000000000000000000000006575 221.0
TLS2_k127_1992925_6 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000216 141.0
TLS2_k127_1992925_7 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0033218,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0055114,GO:0072341,GO:1900750,GO:1901681 - 0.000000000000000000000000000006713 120.0
TLS2_k127_1992925_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000297 104.0
TLS2_k127_1992925_9 AraC-like ligand binding domain - - - 0.0000001105 55.0
TLS2_k127_205700_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.454e-216 686.0
TLS2_k127_205700_1 COG0534 Na -driven multidrug efflux pump K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 422.0
TLS2_k127_205700_10 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000001032 150.0
TLS2_k127_205700_11 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000001002 145.0
TLS2_k127_205700_12 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000001281 149.0
TLS2_k127_205700_13 Transcriptional regulator K16137 - - 0.000000000000000000000000000000000006176 146.0
TLS2_k127_205700_14 Acetyltransferase (GNAT) domain - - - 0.000000000000000000302 94.0
TLS2_k127_205700_15 Lipid A Biosynthesis N-terminal domain - - - 0.0000000000000000006451 90.0
TLS2_k127_205700_16 PFAM phosphoesterase, PA-phosphatase related - - - 0.0000000000000135 84.0
TLS2_k127_205700_17 - - - - 0.00000000001767 74.0
TLS2_k127_205700_2 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway K00927 GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000997 389.0
TLS2_k127_205700_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005646 391.0
TLS2_k127_205700_4 N-terminal half of MaoC dehydratase K09709,K18291 - 4.2.1.153,4.2.1.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 334.0
TLS2_k127_205700_5 PFAM regulatory protein LysR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000581 270.0
TLS2_k127_205700_6 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000001726 260.0
TLS2_k127_205700_7 Nudix N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000001728 236.0
TLS2_k127_205700_8 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001086 223.0
TLS2_k127_205700_9 probably involved in intracellular septation K06190 - - 0.00000000000000000000000000000000000000000000000000000131 198.0
TLS2_k127_2079368_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 8.212e-304 948.0
TLS2_k127_2079368_1 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 397.0
TLS2_k127_2079368_10 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000002827 177.0
TLS2_k127_2079368_11 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000000000000000426 182.0
TLS2_k127_2079368_12 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000006596 169.0
TLS2_k127_2079368_13 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000001878 140.0
TLS2_k127_2079368_14 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000009068 111.0
TLS2_k127_2079368_15 Methionine synthase vitamin-B12 independent K00549 - 2.1.1.14 0.0000001116 53.0
TLS2_k127_2079368_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 389.0
TLS2_k127_2079368_3 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 289.0
TLS2_k127_2079368_4 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 298.0
TLS2_k127_2079368_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001094 287.0
TLS2_k127_2079368_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001185 278.0
TLS2_k127_2079368_7 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000004674 249.0
TLS2_k127_2079368_8 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000007268 249.0
TLS2_k127_2079368_9 Histidine kinase K07716 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000003013 248.0
TLS2_k127_2079767_0 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 531.0
TLS2_k127_2079767_1 Zn-dependent protease, contains TPR repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 385.0
TLS2_k127_2079767_2 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000007909 217.0
TLS2_k127_2079767_3 CHAD - - - 0.0000000000000000000004387 108.0
TLS2_k127_2089991_0 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 2.555e-299 927.0
TLS2_k127_2089991_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.934e-227 713.0
TLS2_k127_2089991_10 phosphoserine phosphatase K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009199 288.0
TLS2_k127_2089991_11 maleylacetoacetate isomerase K01801 - 5.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000003373 250.0
TLS2_k127_2089991_12 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000001095 228.0
TLS2_k127_2089991_13 Acetolactate synthase small K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000002807 188.0
TLS2_k127_2089991_14 Tripartite ATP-independent periplasmic transporter DctQ component - - - 0.00000000000000000000000000000000000000000000009881 188.0
TLS2_k127_2089991_15 FR47-like protein - - - 0.000000000000000000000000000000000001804 153.0
TLS2_k127_2089991_16 FR47-like protein - - - 0.000000000000000000001406 110.0
TLS2_k127_2089991_17 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000000001334 76.0
TLS2_k127_2089991_2 TRAP-type C4-dicarboxylate transport system, large permease component - - - 6.131e-203 649.0
TLS2_k127_2089991_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 513.0
TLS2_k127_2089991_4 GMP synthase C terminal domain K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 482.0
TLS2_k127_2089991_5 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 439.0
TLS2_k127_2089991_6 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006787 410.0
TLS2_k127_2089991_7 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 355.0
TLS2_k127_2089991_8 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005266 344.0
TLS2_k127_2089991_9 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 325.0
TLS2_k127_211735_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 527.0
TLS2_k127_211735_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 481.0
TLS2_k127_211735_2 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 345.0
TLS2_k127_211735_3 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 355.0
TLS2_k127_211735_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006683 297.0
TLS2_k127_211735_5 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000001459 223.0
TLS2_k127_211992_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.968e-246 774.0
TLS2_k127_211992_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 598.0
TLS2_k127_211992_2 Rod shape-determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 572.0
TLS2_k127_211992_3 Aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 549.0
TLS2_k127_211992_4 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 479.0
TLS2_k127_211992_5 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000389 214.0
TLS2_k127_211992_6 alpha beta - - - 0.00000000000000000000000000000000000000003132 162.0
TLS2_k127_211992_7 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000008423 143.0
TLS2_k127_211992_8 Acetolactate synthase small K01653 - 2.2.1.6 0.000000000000000000000000004398 111.0
TLS2_k127_2124771_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.575e-243 759.0
TLS2_k127_2124771_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 443.0
TLS2_k127_2124771_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000336 198.0
TLS2_k127_2124771_3 Ubiquinol-cytochrome C chaperone K17662 - - 0.000000000000000000000000000000000002507 144.0
TLS2_k127_2124771_4 Uncharacterized ACR, COG1399 - - - 0.000000000000000000000001731 108.0
TLS2_k127_2124771_5 COG2913 Small protein A (tmRNA-binding) - - - 0.0000000000000000000001566 104.0
TLS2_k127_2124771_6 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000001282 93.0
TLS2_k127_2124771_7 transcriptional regulator - - - 0.00000000000000000002682 101.0
TLS2_k127_2131355_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 5.994e-302 945.0
TLS2_k127_2131355_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 596.0
TLS2_k127_2131355_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 407.0
TLS2_k127_2131355_11 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 340.0
TLS2_k127_2131355_12 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008329 323.0
TLS2_k127_2131355_13 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000000001576 281.0
TLS2_k127_2131355_14 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001761 250.0
TLS2_k127_2131355_15 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000001059 169.0
TLS2_k127_2131355_16 Domain of unknown function (DUF4115) K15539 - - 0.00000000000000000000000000007238 127.0
TLS2_k127_2131355_17 Protein of unknown function (DUF2442) - - - 0.000000000000000000000001436 106.0
TLS2_k127_2131355_18 Dual specificity phosphatase, catalytic domain - - - 0.000000000000000000004689 100.0
TLS2_k127_2131355_2 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 571.0
TLS2_k127_2131355_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 558.0
TLS2_k127_2131355_4 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 532.0
TLS2_k127_2131355_5 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 542.0
TLS2_k127_2131355_6 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 509.0
TLS2_k127_2131355_7 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007857 505.0
TLS2_k127_2131355_8 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 447.0
TLS2_k127_2131355_9 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 421.0
TLS2_k127_2144965_0 4-hydroxyphenylacetate 3-hydroxylase K14534 - 4.2.1.120,5.3.3.3 1.744e-222 703.0
TLS2_k127_2144965_1 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009912 543.0
TLS2_k127_2144965_10 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000001242 213.0
TLS2_k127_2144965_11 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000001793 188.0
TLS2_k127_2144965_12 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000004363 179.0
TLS2_k127_2144965_13 Protein of unknown function, DUF393 - - - 0.0000000000000000000000000000000000000000000004301 170.0
TLS2_k127_2144965_14 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.000000000000000000000000000000001739 134.0
TLS2_k127_2144965_15 - - - - 0.0000000000000000000000000003724 132.0
TLS2_k127_2144965_16 Alpha/beta hydrolase family - - - 0.00000000000002822 76.0
TLS2_k127_2144965_17 Cytochrome c - - - 0.0000008674 62.0
TLS2_k127_2144965_18 - - - - 0.000001397 62.0
TLS2_k127_2144965_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 529.0
TLS2_k127_2144965_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 453.0
TLS2_k127_2144965_4 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 447.0
TLS2_k127_2144965_5 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 316.0
TLS2_k127_2144965_6 Pfam:AmoA K07120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 327.0
TLS2_k127_2144965_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 301.0
TLS2_k127_2144965_8 Reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004603 299.0
TLS2_k127_2144965_9 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005129 250.0
TLS2_k127_2161708_0 sugar phosphatases of the HAD superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000314 280.0
TLS2_k127_2161708_1 COQ9 K18587 - - 0.0000000000000000000000000000000000000000000000000000001154 203.0
TLS2_k127_2161708_2 - - - - 0.0000000000000000000000000000000000000383 147.0
TLS2_k127_2161708_3 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.00000000000000000000000001805 111.0
TLS2_k127_2161708_4 Bacterial-like globin K06886 - - 0.0000000000000000000000001301 113.0
TLS2_k127_2161708_5 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.00000008285 55.0
TLS2_k127_2161708_6 - - - - 0.0000607 53.0
TLS2_k127_2214869_0 FAD dependent oxidoreductase - - - 1.448e-194 627.0
TLS2_k127_2214869_1 Protein of unknown function (DUF3828) - - - 0.00000000000004164 79.0
TLS2_k127_2219056_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 403.0
TLS2_k127_2219056_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 374.0
TLS2_k127_2219056_10 binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000000001222 194.0
TLS2_k127_2219056_11 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000004512 179.0
TLS2_k127_2219056_12 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000009009 170.0
TLS2_k127_2219056_13 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000000007336 177.0
TLS2_k127_2219056_14 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000007244 158.0
TLS2_k127_2219056_15 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000004076 149.0
TLS2_k127_2219056_16 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000000000005733 138.0
TLS2_k127_2219056_17 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000002747 143.0
TLS2_k127_2219056_18 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000000002095 139.0
TLS2_k127_2219056_19 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000009214 119.0
TLS2_k127_2219056_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 312.0
TLS2_k127_2219056_20 Ribosomal protein L30 K02907 - - 0.0000000000000001048 94.0
TLS2_k127_2219056_21 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000002668 78.0
TLS2_k127_2219056_22 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000007149 81.0
TLS2_k127_2219056_3 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 312.0
TLS2_k127_2219056_4 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002953 274.0
TLS2_k127_2219056_5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006302 272.0
TLS2_k127_2219056_6 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000001223 231.0
TLS2_k127_2219056_7 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000001806 243.0
TLS2_k127_2219056_8 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000006162 228.0
TLS2_k127_2219056_9 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000002113 208.0
TLS2_k127_222220_0 Belongs to the thiolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 575.0
TLS2_k127_222220_1 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 404.0
TLS2_k127_222220_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 350.0
TLS2_k127_222220_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis - - - 0.000000000000000000000000000009929 134.0
TLS2_k127_222220_4 - - - - 0.000000000000001146 85.0
TLS2_k127_2229910_0 ribosomal rna small subunit methyltransferase - - - 2.514e-201 638.0
TLS2_k127_2229910_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.091e-200 632.0
TLS2_k127_2229910_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000001731 255.0
TLS2_k127_2229910_3 transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009574 265.0
TLS2_k127_2229910_4 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000003789 217.0
TLS2_k127_2254823_0 RESPONSE REGULATOR receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 580.0
TLS2_k127_2254823_1 Adenylate Guanylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 556.0
TLS2_k127_2254823_10 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000003543 174.0
TLS2_k127_2254823_11 XdhC and CoxI family - - - 0.000000000000000000000000000000000000000003305 162.0
TLS2_k127_2254823_12 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.00000000000000000000000000000000000000001297 161.0
TLS2_k127_2254823_13 Tetratricopeptide repeat - - - 0.00000000000000000000000001434 114.0
TLS2_k127_2254823_14 Trypsin - - - 0.0000000000000000000000386 116.0
TLS2_k127_2254823_15 SMART Sel1 domain protein repeat-containing protein K07126 - - 0.000000007151 67.0
TLS2_k127_2254823_16 ABC transporter K01990,K21397 - - 0.0000000656 61.0
TLS2_k127_2254823_2 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 522.0
TLS2_k127_2254823_3 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 533.0
TLS2_k127_2254823_4 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 510.0
TLS2_k127_2254823_5 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 468.0
TLS2_k127_2254823_6 Bacterial protein of unknown function (DUF899) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 444.0
TLS2_k127_2254823_7 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 377.0
TLS2_k127_2254823_8 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009163 323.0
TLS2_k127_2254823_9 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001133 269.0
TLS2_k127_2280226_0 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009418 520.0
TLS2_k127_2280226_1 PFAM ABC transporter K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 420.0
TLS2_k127_2280226_10 - - - - 0.0000000000000000008015 92.0
TLS2_k127_2280226_11 Patatin-like phospholipase - - - 0.0000000008996 67.0
TLS2_k127_2280226_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 313.0
TLS2_k127_2280226_3 ABC transporter, periplasmic molybdate-binding protein K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 308.0
TLS2_k127_2280226_4 TIGRFAM Molybdate ABC transporter K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 296.0
TLS2_k127_2280226_5 dihydrokaempferol 4-reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005602 287.0
TLS2_k127_2280226_6 DNA-binding transcriptional activator of the SARP family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002864 262.0
TLS2_k127_2280226_7 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000272 220.0
TLS2_k127_2280226_8 EamA-like transporter family K08978 - - 0.00000000000000000000000000000000000000000000000000000008129 207.0
TLS2_k127_2280226_9 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000000000000003096 128.0
TLS2_k127_2281542_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1237.0
TLS2_k127_2281542_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 3.61e-298 934.0
TLS2_k127_2281542_10 Transcriptional regulator - - - 0.0000000001271 64.0
TLS2_k127_2281542_2 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 2.416e-261 831.0
TLS2_k127_2281542_3 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 514.0
TLS2_k127_2281542_4 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000004783 267.0
TLS2_k127_2281542_5 Chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000008299 202.0
TLS2_k127_2281542_6 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000007297 194.0
TLS2_k127_2281542_7 Ferredoxin, 2Fe-2S - - - 0.0000000000000000000000000000000000000000000000126 175.0
TLS2_k127_2281542_8 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000000000004441 128.0
TLS2_k127_2281542_9 Lipopolysaccharide-assembly K03643 - - 0.00000000000002174 87.0
TLS2_k127_2284363_0 Belongs to the UbiD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008963 494.0
TLS2_k127_2284363_1 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.0000000000000000000000000000000000000000000000000000009203 204.0
TLS2_k127_2284363_2 Putative tRNA binding domain K06878 - - 0.0000000000000000000000000000000000000000000000002488 178.0
TLS2_k127_2284363_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.000000000000000000000000000000000000000000007042 179.0
TLS2_k127_2284363_4 transcriptional regulator - - - 0.000000000000000000000000000000000000000004431 163.0
TLS2_k127_2284363_5 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000001218 158.0
TLS2_k127_2284363_6 Belongs to the LOG family - - - 0.000000000000000000000000000000000000007989 160.0
TLS2_k127_2312745_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 387.0
TLS2_k127_2312745_1 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001864 261.0
TLS2_k127_2312745_2 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000002095 171.0
TLS2_k127_2312745_3 Protein of unknown function (DUF3137) - - - 0.00000000000000000005036 106.0
TLS2_k127_231985_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.069e-320 991.0
TLS2_k127_231985_1 of ABC transporters with duplicated ATPase K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 521.0
TLS2_k127_231985_2 drug transmembrane transport K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 406.0
TLS2_k127_231985_3 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 362.0
TLS2_k127_231985_4 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 360.0
TLS2_k127_231985_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000004966 270.0
TLS2_k127_231985_6 Small Multidrug Resistance protein K11741 - - 0.0000000000000000000000000000000000000001709 156.0
TLS2_k127_231985_7 PFAM IS1 transposase - - - 0.0000000000000000000000000000000000000639 145.0
TLS2_k127_231985_8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000000002838 104.0
TLS2_k127_2324864_0 FAD binding domain K00104,K05797 - 1.1.3.15,1.17.99.1 1.288e-209 662.0
TLS2_k127_2324864_1 Circularly permuted ATP-grasp type 2 - - - 9.86e-209 660.0
TLS2_k127_2324864_10 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008426 346.0
TLS2_k127_2324864_11 PFAM 20S proteasome A and B subunits K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 290.0
TLS2_k127_2324864_12 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005304 282.0
TLS2_k127_2324864_13 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000006416 241.0
TLS2_k127_2324864_14 COG1305 Transglutaminase-like enzymes - - - 0.000000000000000000000000000000000000000000000000000000000002113 216.0
TLS2_k127_2324864_15 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000001892 202.0
TLS2_k127_2324864_16 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000001694 195.0
TLS2_k127_2324864_17 BioY family K03523 - - 0.00000000000000000000000000000000000000000000000003815 184.0
TLS2_k127_2324864_18 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000278 183.0
TLS2_k127_2324864_19 Protein of unknown function (DUF3088) - - - 0.0000000000000000000000000000000000000002492 172.0
TLS2_k127_2324864_2 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 533.0
TLS2_k127_2324864_20 4Fe-4S binding domain - - - 0.0000000000000000000005214 96.0
TLS2_k127_2324864_21 - - - - 0.00000000000000000000102 103.0
TLS2_k127_2324864_22 protein with SCP PR1 domains - - - 0.0000000000000000001069 97.0
TLS2_k127_2324864_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 530.0
TLS2_k127_2324864_4 4Fe-4S dicluster domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 490.0
TLS2_k127_2324864_5 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 468.0
TLS2_k127_2324864_6 amp-dependent synthetase and ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 464.0
TLS2_k127_2324864_7 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 435.0
TLS2_k127_2324864_8 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 417.0
TLS2_k127_2324864_9 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 396.0
TLS2_k127_2325904_0 Mo-co oxidoreductase dimerisation domain K17225 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 574.0
TLS2_k127_2325904_1 Cytochrome c K17230 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 506.0
TLS2_k127_2325904_10 SMART extracellular solute-binding protein, family 3 K02030 - - 0.0000000000000000000000000000005754 132.0
TLS2_k127_2325904_11 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000005182 119.0
TLS2_k127_2325904_12 Cytochrome c K08738 - - 0.000000000000000000009062 105.0
TLS2_k127_2325904_13 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000008931 60.0
TLS2_k127_2325904_14 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0001151 52.0
TLS2_k127_2325904_2 Cytochrome c K17230 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 484.0
TLS2_k127_2325904_3 ATPase with chaperone activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 457.0
TLS2_k127_2325904_4 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004591 437.0
TLS2_k127_2325904_5 Cytochrome c K08738 - - 0.0000000000000000000000000000000000000000000000000000000000000000008357 235.0
TLS2_k127_2325904_6 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000004102 210.0
TLS2_k127_2325904_7 Sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000000000000000001003 181.0
TLS2_k127_2325904_8 Sulphur oxidation protein SoxZ K17227 - - 0.00000000000000000000000000000000000009092 153.0
TLS2_k127_2325904_9 Regulatory protein SoxS - - - 0.0000000000000000000000000000000006016 134.0
TLS2_k127_2338721_0 Tannase and feruloyl esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 580.0
TLS2_k127_2338721_1 malonyl CoA-acyl carrier protein transacylase K00645,K15327 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 423.0
TLS2_k127_2338721_2 - - - - 0.000000000000000000000000000000000001081 146.0
TLS2_k127_2338721_3 PIN domain K07063 - - 0.00000000000000000000000003674 116.0
TLS2_k127_2338721_4 LTXXQ motif family protein - - - 0.0000000000001261 82.0
TLS2_k127_2338848_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 7.261e-232 729.0
TLS2_k127_2338848_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 2.218e-196 641.0
TLS2_k127_2338848_10 transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007056 274.0
TLS2_k127_2338848_11 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000006227 228.0
TLS2_k127_2338848_12 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000005765 223.0
TLS2_k127_2338848_13 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000003049 193.0
TLS2_k127_2338848_14 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000002093 159.0
TLS2_k127_2338848_15 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.0000000000000000000000000000000003531 138.0
TLS2_k127_2338848_16 SCP-2 sterol transfer family - - - 0.00000000000000000000000000000006706 130.0
TLS2_k127_2338848_17 2-oxopent-4-enoate hydratase activity K02554 - 4.2.1.80 0.000000000000000000000000000001769 130.0
TLS2_k127_2338848_18 PAS domain - - - 0.000000000000000000000000000001931 128.0
TLS2_k127_2338848_19 PFAM YcfA-like - - - 0.00000000000000000000000000001148 119.0
TLS2_k127_2338848_2 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 474.0
TLS2_k127_2338848_20 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000003645 91.0
TLS2_k127_2338848_21 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000682 87.0
TLS2_k127_2338848_22 - - - - 0.0000000000005827 77.0
TLS2_k127_2338848_3 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 353.0
TLS2_k127_2338848_4 Tryptophan 2,3-dioxygenase K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 334.0
TLS2_k127_2338848_5 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 330.0
TLS2_k127_2338848_6 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 323.0
TLS2_k127_2338848_7 Aminotransferase class I and II K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 301.0
TLS2_k127_2338848_8 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 302.0
TLS2_k127_2338848_9 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005822 277.0
TLS2_k127_2354198_0 Dehydratase family K01687,K22186 - 4.2.1.82,4.2.1.9 1.383e-300 930.0
TLS2_k127_2354198_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 361.0
TLS2_k127_2354198_2 PFAM Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001446 263.0
TLS2_k127_2354198_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000003597 170.0
TLS2_k127_2354198_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000009656 126.0
TLS2_k127_2354198_5 Protein of unknown function (DUF971) K00471 - 1.14.11.1 0.000000000005645 76.0
TLS2_k127_2354198_6 GIY-YIG catalytic domain K07461 - - 0.00000000003577 64.0
TLS2_k127_2392728_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 531.0
TLS2_k127_2392728_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008036 524.0
TLS2_k127_2392728_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 415.0
TLS2_k127_2392728_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000003487 235.0
TLS2_k127_2392728_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000004057 234.0
TLS2_k127_2392728_5 epimerase - - - 0.0000000000000000000000000000000000000000000000000000006666 203.0
TLS2_k127_2392728_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000008905 157.0
TLS2_k127_2392728_7 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.0000000000000000005476 87.0
TLS2_k127_2398518_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 5.456e-229 731.0
TLS2_k127_2398518_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 8.071e-203 639.0
TLS2_k127_2398518_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000012 177.0
TLS2_k127_2398518_11 - - - - 0.0000000000000000000000000000000000000000002444 168.0
TLS2_k127_2398518_12 EF-hand, calcium binding motif - - - 0.0000000000000000000005225 109.0
TLS2_k127_2398518_14 translation initiation inhibitor, yjgF family - - - 0.00000136 50.0
TLS2_k127_2398518_2 Belongs to the thiolase family K00626 - 2.3.1.9 1.088e-194 614.0
TLS2_k127_2398518_3 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 606.0
TLS2_k127_2398518_4 Amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 556.0
TLS2_k127_2398518_5 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 486.0
TLS2_k127_2398518_6 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 482.0
TLS2_k127_2398518_7 alpha/beta hydrolase fold K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 361.0
TLS2_k127_2398518_8 Polyhydroxyalkanoate synthesis repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000003805 226.0
TLS2_k127_2398518_9 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000000000000000000000000007498 191.0
TLS2_k127_2426827_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 484.0
TLS2_k127_2426827_1 ABC transporter K10441 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 391.0
TLS2_k127_2426827_2 3-beta hydroxysteroid dehydrogenase/isomerase family K22025 - 1.1.1.410 0.0000000000000000000000000000000000000000000000000000000000000006306 224.0
TLS2_k127_2426827_3 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000001578 233.0
TLS2_k127_2426827_4 Gentisate 1,2-dioxygenase K00450 - 1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000001649 225.0
TLS2_k127_2426827_5 Periplasmic substrate-binding component of the ATP-dependent ribose transport system K10439,K17202 - - 0.000000000000000000000000000000000000000000008725 174.0
TLS2_k127_2427011_0 Belongs to the 5'-nucleotidase family K17224 - - 4.856e-268 834.0
TLS2_k127_2427011_1 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 544.0
TLS2_k127_2427011_2 NMT1/THI5 like K15598 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005549 419.0
TLS2_k127_2427011_3 Cytochrome c biogenesis protein K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004747 274.0
TLS2_k127_2427011_4 ABC transporter K15600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001196 271.0
TLS2_k127_2427011_5 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K15599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003035 281.0
TLS2_k127_2427011_6 aminotransferase class I and II K12252 - 2.6.1.84 0.00000000000000000000000000000000000000000000000000000000000000001145 229.0
TLS2_k127_2427011_7 - - - - 0.000000000000000000000000000000000000000000000000000003202 207.0
TLS2_k127_2427011_8 COG0625 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000007668 131.0
TLS2_k127_2457521_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1028.0
TLS2_k127_2457521_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K15738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 612.0
TLS2_k127_2457521_10 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000007062 174.0
TLS2_k127_2457521_11 Domain of unknown function (DUF1476) - - - 0.0000000000000000000000000000003505 126.0
TLS2_k127_2457521_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000004651 125.0
TLS2_k127_2457521_13 BolA-like protein - - - 0.000000000000000000000000002008 130.0
TLS2_k127_2457521_14 Rhomboid family - - - 0.00000000000000000000000001241 124.0
TLS2_k127_2457521_15 Acetyltransferase (GNAT) family - - - 0.000000000000000000000002411 111.0
TLS2_k127_2457521_16 Protein of unknown function (DUF2927) - - - 0.00000000000000000000004018 108.0
TLS2_k127_2457521_17 Belongs to the MraZ family K03925 - - 0.000000000000000000006542 98.0
TLS2_k127_2457521_18 - - - - 0.00000000000000000006071 94.0
TLS2_k127_2457521_19 - - - - 0.0000000000004611 78.0
TLS2_k127_2457521_2 PFAM Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 544.0
TLS2_k127_2457521_20 secreted (periplasmic) protein - - - 0.00000000001793 76.0
TLS2_k127_2457521_3 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 437.0
TLS2_k127_2457521_4 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 397.0
TLS2_k127_2457521_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005926 344.0
TLS2_k127_2457521_6 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 323.0
TLS2_k127_2457521_7 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001463 284.0
TLS2_k127_2457521_8 COG3023 Negative regulator of beta-lactamase expression K01447 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000001529 276.0
TLS2_k127_2457521_9 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily K15268 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008911 267.0
TLS2_k127_2478847_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 3.441e-198 634.0
TLS2_k127_2478847_1 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004329 479.0
TLS2_k127_2478847_2 Histidine ammonia-lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 385.0
TLS2_k127_2478847_3 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007417 338.0
TLS2_k127_2478847_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000278 243.0
TLS2_k127_2478847_5 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000007616 215.0
TLS2_k127_2478847_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000001578 211.0
TLS2_k127_2478847_7 FCD - - - 0.00000000000000000000000000000000000000156 170.0
TLS2_k127_2478847_8 - - - - 0.0007031 47.0
TLS2_k127_2585121_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 490.0
TLS2_k127_2585121_1 amine oxidase K06954 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 455.0
TLS2_k127_2585121_10 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03089 - - 0.00000002837 57.0
TLS2_k127_2585121_11 metal-dependent phosphohydrolase HD region - - - 0.00001059 56.0
TLS2_k127_2585121_2 Domain of unknown function DUF21 K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 416.0
TLS2_k127_2585121_3 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 402.0
TLS2_k127_2585121_4 Cell cycle protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 379.0
TLS2_k127_2585121_5 Protein of unknown function (DUF1365) K09701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003409 282.0
TLS2_k127_2585121_6 Belongs to the peptidase S8 family K14645 - - 0.00000000000000000000000000000000002197 145.0
TLS2_k127_2585121_7 Protein of unknown function (DUF3833) - - - 0.0000000000000000000000000005989 120.0
TLS2_k127_2585121_8 Penicillin binding protein transpeptidase domain - - - 0.0000000000000000000000001188 125.0
TLS2_k127_2585121_9 - - - - 0.0000000001004 72.0
TLS2_k127_259272_0 ATPase with chaperone activity K07391 - - 2.553e-243 762.0
TLS2_k127_259272_1 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009964 509.0
TLS2_k127_259272_2 - - - - 0.00000000000000000000000000000000000000000000000002664 187.0
TLS2_k127_259272_3 Protein of unknown function (DUF2459) - - - 0.0000000000000000000000000004461 121.0
TLS2_k127_259272_4 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000003845 66.0
TLS2_k127_2593067_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.743e-235 739.0
TLS2_k127_2593067_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 2.172e-221 709.0
TLS2_k127_2593067_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 578.0
TLS2_k127_2593067_3 TRAP transporter solute receptor TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 424.0
TLS2_k127_2593067_4 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 331.0
TLS2_k127_2593067_5 serine threonine protein kinase K08282 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001408 283.0
TLS2_k127_2593067_6 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000008393 254.0
TLS2_k127_2593067_7 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.0000000000000000000000000000000000000000000000000000000001062 209.0
TLS2_k127_2593067_8 peptidase C14 caspase catalytic subunit p20 - - - 0.000000000000000000000000000001293 138.0
TLS2_k127_2641430_0 COG2217 Cation transport ATPase K01533 - 3.6.3.4 1.587e-257 818.0
TLS2_k127_2641430_1 metal-dependent hydrolase of the TIM-barrel fold K03392,K10220 - 4.1.1.45,4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 601.0
TLS2_k127_2641430_10 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 351.0
TLS2_k127_2641430_11 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 294.0
TLS2_k127_2641430_12 Aldolase/RraA K10218 - 4.1.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 295.0
TLS2_k127_2641430_13 Domain of unknown function (DUF1932) K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 301.0
TLS2_k127_2641430_14 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003242 296.0
TLS2_k127_2641430_15 short-chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003092 263.0
TLS2_k127_2641430_16 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001461 237.0
TLS2_k127_2641430_17 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000005986 237.0
TLS2_k127_2641430_18 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.00000000000000000000000000000000000000000000000000000000000004104 216.0
TLS2_k127_2641430_19 TIGRFAM TRAP transporter solute receptor, TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000008418 222.0
TLS2_k127_2641430_2 Nitrogen fixation protein fixG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 587.0
TLS2_k127_2641430_20 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000001286 187.0
TLS2_k127_2641430_21 response regulator - - - 0.000000000000000000000000000000000000000003298 162.0
TLS2_k127_2641430_22 AI-2E family transporter - - - 0.000000000000000000000000000000000000000003446 170.0
TLS2_k127_2641430_23 FixH - - - 0.000000000000000000000001391 120.0
TLS2_k127_2641430_24 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04099,K04101 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0036238,GO:0042537,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 1.13.11.57,1.13.11.8 0.00000000000000004963 89.0
TLS2_k127_2641430_25 cytochrome oxidase maturation protein - - - 0.00000000000007544 82.0
TLS2_k127_2641430_26 PFAM Cbb3-type cytochrome oxidase component K00407 - - 0.000000003202 60.0
TLS2_k127_2641430_27 Bacterial protein of unknown function (DUF883) - - - 0.0001502 53.0
TLS2_k127_2641430_3 TRAP transporter, 4TM 12TM fusion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006468 572.0
TLS2_k127_2641430_4 PrpF protein K16514 - 5.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 482.0
TLS2_k127_2641430_5 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 474.0
TLS2_k127_2641430_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 476.0
TLS2_k127_2641430_7 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 453.0
TLS2_k127_2641430_8 methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 377.0
TLS2_k127_2641430_9 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 366.0
TLS2_k127_265792_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007764 496.0
TLS2_k127_265792_1 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001957 260.0
TLS2_k127_265792_2 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000003335 229.0
TLS2_k127_265792_3 Ankyrin repeats (3 copies) - - - 0.000000000000000000000000000000000000000000000000000000000002799 216.0
TLS2_k127_2669201_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 512.0
TLS2_k127_2669201_1 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 376.0
TLS2_k127_2669201_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 350.0
TLS2_k127_2669201_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004077 290.0
TLS2_k127_2669201_4 transport system periplasmic component K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000002101 239.0
TLS2_k127_2669201_5 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000001672 222.0
TLS2_k127_2669201_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000001802 115.0
TLS2_k127_2692106_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 4.148e-228 715.0
TLS2_k127_2692106_1 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 7.498e-203 641.0
TLS2_k127_2692106_10 monooxygenase activity - - - 0.00000000000000000000000000000000000000000000008729 177.0
TLS2_k127_2692106_11 Universal stress protein UspA - - - 0.00000000000000000000000000000000000000000004342 171.0
TLS2_k127_2692106_12 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - - 0.0000000000000000000000000000000219 138.0
TLS2_k127_2692106_13 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.0000000000000000000000003352 106.0
TLS2_k127_2692106_14 peptidyl-tyrosine modification K06138 - - 0.0000000000000000000009501 108.0
TLS2_k127_2692106_15 TfoX N-terminal domain K07343 - - 0.0000000000000000000258 98.0
TLS2_k127_2692106_16 Plasmid stabilization system - - - 0.0000000000000000003183 90.0
TLS2_k127_2692106_17 Ribbon-helix-helix domain - - - 0.0000000000007655 82.0
TLS2_k127_2692106_2 peptidyl-tyrosine modification K06139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009468 488.0
TLS2_k127_2692106_3 translation release factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000987 421.0
TLS2_k127_2692106_4 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005823 389.0
TLS2_k127_2692106_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 368.0
TLS2_k127_2692106_6 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137,K06138 - 1.3.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 359.0
TLS2_k127_2692106_7 Malate/L-lactate dehydrogenase K13574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 366.0
TLS2_k127_2692106_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008168 268.0
TLS2_k127_2692106_9 - - - - 0.000000000000000000000000000000000000000000000000000000000009861 215.0
TLS2_k127_269214_0 COG2030 Acyl dehydratase K14449 - 4.2.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 506.0
TLS2_k127_269214_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008327 481.0
TLS2_k127_269214_10 Protein of unknown function (DUF2852) - - - 0.0000000000000000000000000000000000001425 146.0
TLS2_k127_269214_11 membrane - - - 0.00000000000000000000000000000000009321 151.0
TLS2_k127_269214_12 phosphorelay signal transduction system - - - 0.000000000000000000000000000005646 127.0
TLS2_k127_269214_2 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 380.0
TLS2_k127_269214_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 331.0
TLS2_k127_269214_4 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 344.0
TLS2_k127_269214_5 WHG domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005487 305.0
TLS2_k127_269214_6 Phosphomethylpyrimidine kinase K00868 - 2.7.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000789 250.0
TLS2_k127_269214_7 LysE type translocator - - - 0.00000000000000000000000000000000000000000001924 169.0
TLS2_k127_269214_8 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.0000000000000000000000000000000000000002073 153.0
TLS2_k127_269214_9 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.00000000000000000000000000000000000002079 151.0
TLS2_k127_2696708_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 484.0
TLS2_k127_2696708_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 315.0
TLS2_k127_2696708_2 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 284.0
TLS2_k127_2696708_3 Phytoene squalene synthetase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000003691 212.0
TLS2_k127_2696708_4 Preprotein translocase subunit YajC K03210 - - 0.000000000000000000000000003172 115.0
TLS2_k127_2696708_5 - - - - 0.00000001359 60.0
TLS2_k127_2707752_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1313.0
TLS2_k127_2707752_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005639 618.0
TLS2_k127_2707752_10 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000408 234.0
TLS2_k127_2707752_11 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000002564 128.0
TLS2_k127_2707752_12 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.0000000000000000000000001802 108.0
TLS2_k127_2707752_13 - - - - 0.000000001595 63.0
TLS2_k127_2707752_2 COG2309 Leucyl aminopeptidase (aminopeptidase T) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 493.0
TLS2_k127_2707752_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 464.0
TLS2_k127_2707752_4 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 473.0
TLS2_k127_2707752_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 449.0
TLS2_k127_2707752_6 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 423.0
TLS2_k127_2707752_7 Lytic murein transglycosylase K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 394.0
TLS2_k127_2707752_8 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 375.0
TLS2_k127_2707752_9 Lytic murein transglycosylase K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001713 262.0
TLS2_k127_272610_0 Belongs to the aldehyde dehydrogenase family K00130,K00151,K10217 GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0008802,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85 3.974e-230 722.0
TLS2_k127_272610_1 Pfam Periplasmic binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003092 263.0
TLS2_k127_272610_2 PFAM MOSC domain - - - 0.0000000001891 61.0
TLS2_k127_272847_0 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 473.0
TLS2_k127_272847_1 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 409.0
TLS2_k127_272847_2 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000002963 214.0
TLS2_k127_272847_3 Cupin domain - - - 0.000000000000000000000000000000000000000000000009667 190.0
TLS2_k127_272847_4 Diguanylate cyclase (GGDEF) domain - - - 0.0000000000000000000000000000000000000001024 168.0
TLS2_k127_272847_5 LysE type translocator - - - 0.0000000000000000000000001678 113.0
TLS2_k127_2764831_0 ATP-dependent helicase K03579 - 3.6.4.13 2.297e-305 956.0
TLS2_k127_2764831_1 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 561.0
TLS2_k127_2764831_10 PFAM cytochrome c, class I K17230 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000005208 78.0
TLS2_k127_2764831_2 Sulfide dehydrogenase K17229 - 1.8.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 515.0
TLS2_k127_2764831_3 MBOAT, membrane-bound O-acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 509.0
TLS2_k127_2764831_4 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 326.0
TLS2_k127_2764831_5 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000000000000000000000002441 215.0
TLS2_k127_2764831_6 Thioredoxin-like domain - - - 0.0000000000000000000000000000000000000000000007428 169.0
TLS2_k127_2764831_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000006391 160.0
TLS2_k127_2764831_8 Protein of unknown function (DUF459) K09795 - - 0.00000000000000000000000000000000122 140.0
TLS2_k127_2764831_9 Protein of unknown function (DUF459) K09795 - - 0.00000000000000000000000000000007067 135.0
TLS2_k127_2766072_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 497.0
TLS2_k127_2766072_1 phosphoesterase, PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 376.0
TLS2_k127_2766072_2 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.0000000000000000000000000000000000000000000000000000000001371 214.0
TLS2_k127_2766072_3 serine threonine protein kinase K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000002459 181.0
TLS2_k127_2774411_0 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 374.0
TLS2_k127_2774411_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 336.0
TLS2_k127_2774411_2 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000002551 255.0
TLS2_k127_2774411_3 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000466 230.0
TLS2_k127_2774411_4 ABC-type uncharacterized transport system - - - 0.000000000000000000000000000000000000000000000000000000000001698 214.0
TLS2_k127_2774411_5 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874 - 0.00000000000000000000000000000007349 131.0
TLS2_k127_2774411_6 Glycine zipper 2TM domain - - - 0.0000000000000000000000000000004183 130.0
TLS2_k127_282848_0 Belongs to the UbiD family K03182 - 4.1.1.98 1.579e-267 831.0
TLS2_k127_282848_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008726 297.0
TLS2_k127_282848_2 B3 4 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007411 252.0
TLS2_k127_282848_3 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000000000000000000000005113 226.0
TLS2_k127_282848_4 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000001454 188.0
TLS2_k127_282848_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000006753 158.0
TLS2_k127_282848_6 Domain of unknown function (DUF4170) - - - 0.000000000000000000000000000000000000575 143.0
TLS2_k127_282848_8 Putative bacterial sensory transduction regulator - - - 0.0000000004127 70.0
TLS2_k127_282848_9 Glycosyltransferase Family 4 - - - 0.000001218 60.0
TLS2_k127_2829815_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 5.6e-253 792.0
TLS2_k127_2829815_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 303.0
TLS2_k127_2829815_2 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000001297 205.0
TLS2_k127_2829815_3 TspO/MBR family K05770 - - 0.000000000000000000000000000000000000000002564 161.0
TLS2_k127_2829815_4 protein possibly involved in utilization of glycolate and propanediol - - - 0.00000000000000000000000000000000000001062 151.0
TLS2_k127_2829815_5 Pyruvate phosphate dikinase - - - 0.000000000000000000000396 109.0
TLS2_k127_2829815_6 CoA-transferase family III - - - 0.00000003902 57.0
TLS2_k127_2841670_0 Peptidase M10 serralysin C terminal - - - 5.963e-318 1031.0
TLS2_k127_2841670_1 FAD binding domain K00480,K22270 - 1.14.13.1,1.14.13.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 520.0
TLS2_k127_2841670_2 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 445.0
TLS2_k127_2841670_3 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 408.0
TLS2_k127_2841670_4 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 341.0
TLS2_k127_2841670_5 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000004016 190.0
TLS2_k127_2841670_6 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000001605 147.0
TLS2_k127_2841670_7 domain, Protein K01406,K20276 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009405,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0031638,GO:0043170,GO:0044238,GO:0044419,GO:0051604,GO:0051704,GO:0071704,GO:0140096,GO:1901564 3.4.24.40 0.0000000000000001064 96.0
TLS2_k127_2841670_8 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000246 59.0
TLS2_k127_2861034_0 Oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 598.0
TLS2_k127_2861034_1 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 450.0
TLS2_k127_2861034_10 Universal stress protein family - - - 0.0000000000000000000000000000000000000000002646 164.0
TLS2_k127_2861034_11 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000001262 109.0
TLS2_k127_2861034_12 Domain of unknown function (DUF4189) - - - 0.00000000000003199 79.0
TLS2_k127_2861034_13 PFAM Protein kinase domain K08884 - 2.7.11.1 0.00000000002586 73.0
TLS2_k127_2861034_14 Domain of unknown function (DUF4142) K08995 - - 0.000007481 56.0
TLS2_k127_2861034_16 - - - - 0.00004421 55.0
TLS2_k127_2861034_2 AFG1-like ATPase K06916 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 455.0
TLS2_k127_2861034_3 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 362.0
TLS2_k127_2861034_4 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 353.0
TLS2_k127_2861034_5 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 322.0
TLS2_k127_2861034_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 296.0
TLS2_k127_2861034_7 KR domain K00034 - 1.1.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000101 267.0
TLS2_k127_2861034_8 KR domain K00034 - 1.1.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000001532 260.0
TLS2_k127_2861034_9 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000009295 211.0
TLS2_k127_286366_0 PFAM ABC transporter K02471 - - 2.789e-202 650.0
TLS2_k127_286366_1 PHB de-polymerase C-terminus K05973 - 3.1.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000503 559.0
TLS2_k127_286366_10 - - - - 0.000000001245 67.0
TLS2_k127_286366_13 Tetratricopeptide repeat - - - 0.00008936 55.0
TLS2_k127_286366_2 PFAM Cupin 2, conserved barrel K00450 - 1.13.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 474.0
TLS2_k127_286366_3 oxidoreductase FAD NAD(P)-binding domain protein K14581 - 1.18.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 420.0
TLS2_k127_286366_4 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 424.0
TLS2_k127_286366_5 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 387.0
TLS2_k127_286366_6 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 383.0
TLS2_k127_286366_7 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 333.0
TLS2_k127_286366_8 Phenylacetic acid catabolic protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003541 285.0
TLS2_k127_286366_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000001798 130.0
TLS2_k127_2878611_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007338 376.0
TLS2_k127_2878611_1 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 354.0
TLS2_k127_2878611_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 282.0
TLS2_k127_2878611_3 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001284 294.0
TLS2_k127_2878611_4 - - - - 0.0000000000000000000000000000000000001437 145.0
TLS2_k127_2878611_6 - - - - 0.0000000000000000000000000009232 113.0
TLS2_k127_2878611_7 - - - - 0.00000000000005211 74.0
TLS2_k127_2878611_9 - - - - 0.00000001154 66.0
TLS2_k127_2878778_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008601 599.0
TLS2_k127_2878778_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 451.0
TLS2_k127_2878778_10 - - - - 0.000000000005286 76.0
TLS2_k127_2878778_2 SEC-C Motif Domain Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 387.0
TLS2_k127_2878778_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 381.0
TLS2_k127_2878778_4 3-beta hydroxysteroid dehydrogenase/isomerase family K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 373.0
TLS2_k127_2878778_5 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 349.0
TLS2_k127_2878778_6 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003064 272.0
TLS2_k127_2878778_7 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000001986 228.0
TLS2_k127_2878778_8 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.0000000000000000000000000000000000000000000000000001294 192.0
TLS2_k127_2878778_9 Protein of unknown function (DUF983) - - - 0.000000000000000000000006378 117.0
TLS2_k127_2882842_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2e-323 1000.0
TLS2_k127_2882842_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 1.525e-300 960.0
TLS2_k127_2882842_10 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 455.0
TLS2_k127_2882842_11 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006435 423.0
TLS2_k127_2882842_12 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008722 407.0
TLS2_k127_2882842_13 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 389.0
TLS2_k127_2882842_14 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 411.0
TLS2_k127_2882842_15 COG0859 ADP-heptose LPS heptosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 335.0
TLS2_k127_2882842_16 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 336.0
TLS2_k127_2882842_17 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006964 316.0
TLS2_k127_2882842_18 GTP cyclohydrolase K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 301.0
TLS2_k127_2882842_19 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008451 310.0
TLS2_k127_2882842_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.834e-255 807.0
TLS2_k127_2882842_20 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 299.0
TLS2_k127_2882842_21 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 300.0
TLS2_k127_2882842_22 Formate/nitrite transporter K06212 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001863 286.0
TLS2_k127_2882842_23 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001282 278.0
TLS2_k127_2882842_24 OpgC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001774 266.0
TLS2_k127_2882842_25 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000000000007136 227.0
TLS2_k127_2882842_26 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000004884 180.0
TLS2_k127_2882842_27 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000000000000000000000000000000000001047 186.0
TLS2_k127_2882842_28 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000001154 162.0
TLS2_k127_2882842_29 PFAM regulatory protein TetR - - - 0.000000000000000000000000000000000000448 148.0
TLS2_k127_2882842_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 588.0
TLS2_k127_2882842_30 Paraquat-inducible protein A K03808 - - 0.0000000000000000000000006964 111.0
TLS2_k127_2882842_31 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000003181 67.0
TLS2_k127_2882842_32 - - - - 0.000002859 58.0
TLS2_k127_2882842_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 561.0
TLS2_k127_2882842_5 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 542.0
TLS2_k127_2882842_6 DNA polymerase III beta subunit K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 516.0
TLS2_k127_2882842_7 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 518.0
TLS2_k127_2882842_8 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 492.0
TLS2_k127_2882842_9 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 492.0
TLS2_k127_2883259_0 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 490.0
TLS2_k127_2883259_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005835 340.0
TLS2_k127_2883259_10 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000001275 119.0
TLS2_k127_2883259_11 - - - - 0.000000000003701 69.0
TLS2_k127_2883259_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 311.0
TLS2_k127_2883259_3 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000008506 236.0
TLS2_k127_2883259_4 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000000000000000000000000000000000000000001356 224.0
TLS2_k127_2883259_5 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000001477 204.0
TLS2_k127_2883259_6 SMART SH3 domain protein - - - 0.000000000000000000000000000000000000000000000005739 180.0
TLS2_k127_2883259_7 decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000001916 168.0
TLS2_k127_2883259_8 short-chain K00059,K03793 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.100,1.5.1.33 0.000000000000000000000000000000000000000004625 156.0
TLS2_k127_2883259_9 PIN domain - - - 0.000000000000000000000000000000005247 132.0
TLS2_k127_2889600_0 GTP-binding protein TypA K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 1.882e-283 886.0
TLS2_k127_2889600_1 Glycosyl hydrolases family 15 - - - 3.202e-244 769.0
TLS2_k127_2889600_10 Family of unknown function (DUF1028) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 313.0
TLS2_k127_2889600_11 Ureidoglycolate lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 307.0
TLS2_k127_2889600_12 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004962 275.0
TLS2_k127_2889600_13 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004904 260.0
TLS2_k127_2889600_14 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000051 252.0
TLS2_k127_2889600_15 PFAM Creatininase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000002409 242.0
TLS2_k127_2889600_16 PFAM ROK family protein K00845,K00847 - 2.7.1.2,2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000001057 229.0
TLS2_k127_2889600_17 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000001252 191.0
TLS2_k127_2889600_18 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000009769 198.0
TLS2_k127_2889600_19 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000001607 148.0
TLS2_k127_2889600_2 Thiamine pyrophosphate enzyme, central domain - - - 1.833e-215 693.0
TLS2_k127_2889600_20 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000000000000000002008 124.0
TLS2_k127_2889600_21 OmpA family - - - 0.00000000000000000000000006639 120.0
TLS2_k127_2889600_22 Tetratricopeptide repeat - - - 0.00000000000000000000001242 108.0
TLS2_k127_2889600_23 YjbR - - - 0.0000000000000000000003183 110.0
TLS2_k127_2889600_24 InterPro IPR007367 - - - 0.000000000000000000001229 99.0
TLS2_k127_2889600_25 - - - - 0.00000000000000000001133 95.0
TLS2_k127_2889600_26 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000007152 94.0
TLS2_k127_2889600_27 PFAM peptidase S1 and S6 chymotrypsin Hap K08372 - - 0.000000000000000001762 97.0
TLS2_k127_2889600_28 Flp pilus assembly protein, pilin Flp K02651 - - 0.00000000002571 67.0
TLS2_k127_2889600_29 - - - - 0.000000004475 63.0
TLS2_k127_2889600_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.013e-212 672.0
TLS2_k127_2889600_4 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008154 481.0
TLS2_k127_2889600_5 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006862 461.0
TLS2_k127_2889600_6 TIGRFAM methylmalonyl-CoA mutase N-terminal domain K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 446.0
TLS2_k127_2889600_7 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 420.0
TLS2_k127_2889600_8 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 424.0
TLS2_k127_2889600_9 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 333.0
TLS2_k127_289130_0 AMP-binding enzyme C-terminal domain K00666 - - 6.81e-236 746.0
TLS2_k127_289130_1 Bacterial AMP nucleoside phosphorylase N-terminus K01241 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008714,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464 3.2.2.4 4.472e-229 719.0
TLS2_k127_289130_10 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002132 255.0
TLS2_k127_289130_11 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00000000000000000000000000000000000000000000000000000000000006736 230.0
TLS2_k127_289130_12 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000003722 187.0
TLS2_k127_289130_13 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000000000001393 168.0
TLS2_k127_289130_14 Belongs to the UPF0310 family - - - 0.00000000000000000000000000000000000000000002761 184.0
TLS2_k127_289130_15 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000009018 140.0
TLS2_k127_289130_16 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000001648 136.0
TLS2_k127_289130_17 SH3 domain - - - 0.000000000000000000000000000003703 124.0
TLS2_k127_289130_18 - - - - 0.0000000002832 64.0
TLS2_k127_289130_19 Opacity family porin protein - - - 0.00002123 56.0
TLS2_k127_289130_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 1.438e-210 666.0
TLS2_k127_289130_3 Domain of unknown function (DUF3362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 499.0
TLS2_k127_289130_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 445.0
TLS2_k127_289130_5 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008837 402.0
TLS2_k127_289130_6 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 357.0
TLS2_k127_289130_7 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 304.0
TLS2_k127_289130_8 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006755 258.0
TLS2_k127_289130_9 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007492 258.0
TLS2_k127_2892610_0 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000001974 237.0
TLS2_k127_2892610_1 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000001579 180.0
TLS2_k127_2892610_2 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000003572 155.0
TLS2_k127_2900420_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.271e-211 664.0
TLS2_k127_2900420_1 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000737 400.0
TLS2_k127_2900420_10 N-terminal half of MaoC dehydratase - - - 0.0005852 48.0
TLS2_k127_2900420_2 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 380.0
TLS2_k127_2900420_3 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001458 279.0
TLS2_k127_2900420_4 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000002627 201.0
TLS2_k127_2900420_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000003532 196.0
TLS2_k127_2900420_6 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000006804 180.0
TLS2_k127_2900420_7 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000005695 70.0
TLS2_k127_2900420_8 MaoC like domain - - - 0.0000000005318 65.0
TLS2_k127_2900420_9 Domain of unknown function (DUF4189) - - - 0.0000001051 61.0
TLS2_k127_2913826_0 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 339.0
TLS2_k127_2913826_1 Heparinase II/III-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007544 333.0
TLS2_k127_2913826_2 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000002206 185.0
TLS2_k127_2913826_3 S-adenosyl-L-methionine methyltransferase - - - 0.0000000000000000000000000000000000000000006477 167.0
TLS2_k127_2913826_4 ABC transporter transmembrane region K02021 - - 0.0000000000000000000000000005107 116.0
TLS2_k127_2913826_5 16S rRNA methyltransferase RsmB/F K03500 - 2.1.1.176 0.00000000000000000000000001185 111.0
TLS2_k127_2913826_6 S-adenosyl-L-methionine methyltransferase - - - 0.00000000000000000000000001955 123.0
TLS2_k127_2930610_0 AMP-binding enzyme K01897 - 6.2.1.3 6.119e-195 632.0
TLS2_k127_2930610_1 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 316.0
TLS2_k127_2930610_2 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000009246 240.0
TLS2_k127_2930610_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000007154 110.0
TLS2_k127_2930610_4 Glycosyl transferase 4-like domain K19424 - - 0.0005953 46.0
TLS2_k127_2931966_0 inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 534.0
TLS2_k127_2931966_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 512.0
TLS2_k127_2931966_10 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000000000000000001343 238.0
TLS2_k127_2931966_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215 - 0.000000000000001192 84.0
TLS2_k127_2931966_12 protein secretion K03116,K03425 GO:0003674,GO:0005215 - 0.000000000001063 71.0
TLS2_k127_2931966_2 hydrolase, family 3 K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 366.0
TLS2_k127_2931966_3 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 349.0
TLS2_k127_2931966_4 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007673 322.0
TLS2_k127_2931966_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 292.0
TLS2_k127_2931966_6 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008877 291.0
TLS2_k127_2931966_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002774 287.0
TLS2_k127_2931966_8 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000002432 249.0
TLS2_k127_2931966_9 COG1994 Zn-dependent proteases - - - 0.0000000000000000000000000000000000000000000000000000000000000002434 228.0
TLS2_k127_2952986_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1120.0
TLS2_k127_2952986_1 Glutaminyl-tRNA synthetase K01886 - 6.1.1.18 3.843e-298 921.0
TLS2_k127_2952986_10 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 453.0
TLS2_k127_2952986_11 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 475.0
TLS2_k127_2952986_12 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 337.0
TLS2_k127_2952986_13 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 323.0
TLS2_k127_2952986_14 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 320.0
TLS2_k127_2952986_15 alpha/beta hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 307.0
TLS2_k127_2952986_16 serine threonine protein kinase K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000116 297.0
TLS2_k127_2952986_17 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002552 302.0
TLS2_k127_2952986_18 serine threonine protein kinase K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001364 287.0
TLS2_k127_2952986_19 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000003502 284.0
TLS2_k127_2952986_2 Proton-conducting membrane transporter - - - 1.686e-287 896.0
TLS2_k127_2952986_20 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000002732 226.0
TLS2_k127_2952986_21 COG1335 Amidases related to nicotinamidase - - - 0.000000000000000000000000000000000000000000000000000000000004118 214.0
TLS2_k127_2952986_22 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000000000222 189.0
TLS2_k127_2952986_23 - - - - 0.00000000000000000000000000000000000000000000001378 173.0
TLS2_k127_2952986_24 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000008019 184.0
TLS2_k127_2952986_25 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000003365 177.0
TLS2_k127_2952986_26 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000003583 164.0
TLS2_k127_2952986_27 transporter component K07112 - - 0.0000000000000000000000000000000000000000003238 162.0
TLS2_k127_2952986_28 NADH dehydrogenase - - - 0.000000000000000000000000000000000000001093 165.0
TLS2_k127_2952986_29 NUDIX domain - - - 0.0000000000000000000000000000000000009402 145.0
TLS2_k127_2952986_3 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 1.544e-219 704.0
TLS2_k127_2952986_30 Protein tyrosine phosphatase - - - 0.00000000000000000000000000000000001714 143.0
TLS2_k127_2952986_31 PAS domain - - - 0.00000000000000000000000000000000006823 141.0
TLS2_k127_2952986_32 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000001576 133.0
TLS2_k127_2952986_33 Alanine acetyltransferase - - - 0.0000000000000000000000000000001785 125.0
TLS2_k127_2952986_34 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000001105 122.0
TLS2_k127_2952986_35 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000002701 123.0
TLS2_k127_2952986_36 cheY-homologous receiver domain - - - 0.000000000000000000000000004095 120.0
TLS2_k127_2952986_37 Alpha beta hydrolase - - - 0.0000000000000000000000005608 117.0
TLS2_k127_2952986_38 Response regulator receiver - - - 0.000000000000000000000001367 108.0
TLS2_k127_2952986_39 Protein required for attachment to host cells - - - 0.0000000000000004167 84.0
TLS2_k127_2952986_4 Penicillin amidase K01434 - 3.5.1.11 9.019e-212 686.0
TLS2_k127_2952986_41 surface antigen - - - 0.000000000001892 74.0
TLS2_k127_2952986_42 - - - - 0.000000000002792 68.0
TLS2_k127_2952986_43 transcriptional regulator - - - 0.00000000001936 72.0
TLS2_k127_2952986_44 response regulator K02485 - - 0.000003578 49.0
TLS2_k127_2952986_5 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 600.0
TLS2_k127_2952986_6 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 586.0
TLS2_k127_2952986_7 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 528.0
TLS2_k127_2952986_8 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000827 503.0
TLS2_k127_2952986_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008051 513.0
TLS2_k127_2960038_0 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005537 613.0
TLS2_k127_2960038_1 transport system fused permease components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 434.0
TLS2_k127_2960038_2 TRAP transporter solute receptor TAXI family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007989 373.0
TLS2_k127_2960038_3 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 360.0
TLS2_k127_296352_0 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 503.0
TLS2_k127_296352_1 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 448.0
TLS2_k127_296352_2 PaaX-like protein K02616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 345.0
TLS2_k127_296352_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K18361 - 1.17.5.1,3.1.2.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 313.0
TLS2_k127_296352_4 Pyruvate ferredoxin/flavodoxin oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000008953 211.0
TLS2_k127_296352_5 Thioesterase - - - 0.0000000000000000000000000000000009379 137.0
TLS2_k127_296352_6 Toxin-antitoxin system, toxin component, PIN family - - - 0.000000000000000007542 89.0
TLS2_k127_2972159_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1234.0
TLS2_k127_2972159_1 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 5.04e-253 798.0
TLS2_k127_2972159_10 toxin-antitoxin pair type II binding - - - 0.000000000666 66.0
TLS2_k127_2972159_11 Transglycosylase associated protein - - - 0.00000005589 60.0
TLS2_k127_2972159_2 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 421.0
TLS2_k127_2972159_3 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 399.0
TLS2_k127_2972159_4 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 385.0
TLS2_k127_2972159_5 COG1840 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007813 371.0
TLS2_k127_2972159_6 Enoyl-CoA hydratase K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001445 291.0
TLS2_k127_2972159_7 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000005864 207.0
TLS2_k127_2972159_8 Protein of unknown function (DUF1489) - - - 0.00000000000000000000000000000000006928 149.0
TLS2_k127_2972159_9 PFAM Plasmid stabilisation system protein - - - 0.00000000000000000169 88.0
TLS2_k127_3006276_0 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 3.447e-289 891.0
TLS2_k127_3006276_1 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 357.0
TLS2_k127_3006276_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000004146 225.0
TLS2_k127_3006276_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000002294 162.0
TLS2_k127_3006276_4 PIN domain - - - 0.0000000000000000000000000000000008615 134.0
TLS2_k127_3006276_5 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000009457 70.0
TLS2_k127_3006276_6 2TM domain - - - 0.00000005752 61.0
TLS2_k127_3006276_7 PAS domain - - - 0.000003879 58.0
TLS2_k127_3009873_0 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 512.0
TLS2_k127_3009873_1 Rieske [2Fe-2S] domain K18068 - 1.14.12.7 0.0000000000000000000000000000000000000000000000000000000000000000000000001024 260.0
TLS2_k127_3009873_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007517 248.0
TLS2_k127_3009873_3 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.000000000000000000000000000000000000000000000000000000000000000009718 231.0
TLS2_k127_3009873_4 transcriptional regulator K05818 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000007466 213.0
TLS2_k127_3009873_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000001655 169.0
TLS2_k127_3009873_6 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000005953 161.0
TLS2_k127_3036691_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 6.871e-270 837.0
TLS2_k127_3036691_1 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 587.0
TLS2_k127_3036691_2 Oxidoreductase NAD-binding domain K15511 - 1.14.13.208 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 526.0
TLS2_k127_3036691_3 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 470.0
TLS2_k127_3036691_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001674 298.0
TLS2_k127_3036691_5 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000257 244.0
TLS2_k127_3036691_6 Peptidase S41 K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000003138 247.0
TLS2_k127_3036691_7 Predicted integral membrane protein (DUF2189) - - - 0.000000000000000000000000000000000000000000000000000000000003013 218.0
TLS2_k127_3036691_8 Universal stress protein UspA - - - 0.000000000000000000000000000000000000000000000000001261 192.0
TLS2_k127_3036691_9 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.0000000000000000000000000000000000000000000001597 171.0
TLS2_k127_3042127_0 Cell division protein FtsI penicillin-binding protein 2 K05515 - 3.4.16.4 1.423e-197 644.0
TLS2_k127_3042127_1 Rod shape-determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 583.0
TLS2_k127_3042127_10 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000000000000009289 152.0
TLS2_k127_3042127_11 PFAM conserved - - - 0.00000000000000000000000000008159 126.0
TLS2_k127_3042127_12 shape-determining protein K03571 - - 0.000000000000000000000000008263 123.0
TLS2_k127_3042127_13 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.00000000000000000000001926 100.0
TLS2_k127_3042127_14 Protein of unknown function (DUF2794) - - - 0.000000000000000000009633 98.0
TLS2_k127_3042127_15 - - - - 0.000000000006032 76.0
TLS2_k127_3042127_16 - - - - 0.000000005645 68.0
TLS2_k127_3042127_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 524.0
TLS2_k127_3042127_3 COG1520 FOG WD40-like repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005936 421.0
TLS2_k127_3042127_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 398.0
TLS2_k127_3042127_5 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 361.0
TLS2_k127_3042127_6 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 291.0
TLS2_k127_3042127_7 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000009246 200.0
TLS2_k127_3042127_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000247 197.0
TLS2_k127_3042127_9 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000004444 162.0
TLS2_k127_3046436_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K14446 - 1.3.1.85 4.629e-245 760.0
TLS2_k127_3046436_1 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 586.0
TLS2_k127_3046436_2 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 529.0
TLS2_k127_3049392_0 AcrB/AcrD/AcrF family K18138,K18307 - - 0.0 1234.0
TLS2_k127_3049392_1 COG1042 Acyl-CoA synthetase (NDP forming) K09181 - - 4.131e-318 997.0
TLS2_k127_3049392_10 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000003323 235.0
TLS2_k127_3049392_11 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.0000000000000000000000000000000000000000000000000000001856 211.0
TLS2_k127_3049392_12 - - - - 0.00000000000000000000000000000000000000000000000000008877 198.0
TLS2_k127_3049392_13 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000000000000000000006589 193.0
TLS2_k127_3049392_14 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000000000000000000000000002777 179.0
TLS2_k127_3049392_15 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000001175 167.0
TLS2_k127_3049392_16 Bacterial transcriptional regulator - - - 0.000000000000000000000000000002357 131.0
TLS2_k127_3049392_17 Protein of unknown function (DUF1150) - - - 0.00000000000000266 79.0
TLS2_k127_3049392_19 Major facilitator superfamily K08218 - - 0.00002448 57.0
TLS2_k127_3049392_2 Phosphate transport system permease K02038 - - 4.629e-230 726.0
TLS2_k127_3049392_3 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 526.0
TLS2_k127_3049392_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 406.0
TLS2_k127_3049392_5 phosphate regulon transcriptional regulatory protein PhoB K07657,K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 370.0
TLS2_k127_3049392_6 HlyD family secretion protein K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 297.0
TLS2_k127_3049392_7 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007922 276.0
TLS2_k127_3049392_8 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007375 287.0
TLS2_k127_3049392_9 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000004145 266.0
TLS2_k127_3050901_0 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 606.0
TLS2_k127_3050901_1 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000027 236.0
TLS2_k127_3050901_2 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.0000000000000000000000000000000000000000000000000001861 189.0
TLS2_k127_3059944_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 1.645e-208 659.0
TLS2_k127_3059944_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 439.0
TLS2_k127_3059944_2 - - - - 0.0001128 53.0
TLS2_k127_3069819_0 Fibronectin type III-like domain K05349 - 3.2.1.21 1.33e-262 827.0
TLS2_k127_3069819_1 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - 4.021e-236 745.0
TLS2_k127_3069819_10 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 316.0
TLS2_k127_3069819_11 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000239 250.0
TLS2_k127_3069819_12 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000001242 212.0
TLS2_k127_3069819_13 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000002227 216.0
TLS2_k127_3069819_14 Belongs to the globin family - - - 0.0000000000000000000000000000000000006339 162.0
TLS2_k127_3069819_2 Periplasmic binding protein K01999 - - 7.438e-223 699.0
TLS2_k127_3069819_3 PFAM ABC transporter K02471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009894 527.0
TLS2_k127_3069819_4 Methionine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 492.0
TLS2_k127_3069819_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 456.0
TLS2_k127_3069819_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009391 452.0
TLS2_k127_3069819_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 329.0
TLS2_k127_3069819_8 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 333.0
TLS2_k127_3069819_9 ATPases associated with a variety of cellular activities K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 305.0
TLS2_k127_3086255_0 AMP-binding enzyme K01897 - 6.2.1.3 2.541e-233 737.0
TLS2_k127_3086255_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 544.0
TLS2_k127_3086255_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 297.0
TLS2_k127_3086255_11 esterase K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 301.0
TLS2_k127_3086255_12 AraC-binding-like domain - - - 0.0000000000000000000000000000000000000000000000000000000003287 216.0
TLS2_k127_3086255_13 PFAM Glutathione S-transferase domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000001368 210.0
TLS2_k127_3086255_14 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000001478 189.0
TLS2_k127_3086255_15 LppP/LprE lipoprotein - - - 0.000000000000000000000000000001858 128.0
TLS2_k127_3086255_16 RHS Repeat - - - 0.000000000000000000000005872 106.0
TLS2_k127_3086255_17 PilZ domain - - - 0.0004185 47.0
TLS2_k127_3086255_18 Immunity protein 32 - - - 0.0009013 48.0
TLS2_k127_3086255_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 410.0
TLS2_k127_3086255_3 nitrilase K01501,K01502 - 3.5.5.1,3.5.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 413.0
TLS2_k127_3086255_4 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 381.0
TLS2_k127_3086255_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 352.0
TLS2_k127_3086255_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 323.0
TLS2_k127_3086255_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 323.0
TLS2_k127_3086255_8 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 312.0
TLS2_k127_3086255_9 branched-chain amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004051 328.0
TLS2_k127_3088034_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 2.54e-228 719.0
TLS2_k127_3088034_1 FAD binding domain K10676 - 1.14.13.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 409.0
TLS2_k127_3088034_2 PFAM MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000003762 206.0
TLS2_k127_311086_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 2.25e-287 902.0
TLS2_k127_311086_1 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 4.238e-282 876.0
TLS2_k127_311086_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 370.0
TLS2_k127_311086_3 ATPases associated with a variety of cellular activities K01995,K11957 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 347.0
TLS2_k127_311086_4 amino acid ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 301.0
TLS2_k127_311086_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 316.0
TLS2_k127_311086_6 Isochorismatase family K09020 - 3.5.1.110 0.000000000000000000000000000000000000000000000000000000000000000000000000003402 257.0
TLS2_k127_311086_7 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000009188 243.0
TLS2_k127_311086_8 Isocitrate lyase family - - - 0.0000007588 51.0
TLS2_k127_3128370_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 0.0 1227.0
TLS2_k127_3128370_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 488.0
TLS2_k127_3128370_2 membrane protein, required for colicin V production K03558 - - 0.0000000000000000000000000502 123.0
TLS2_k127_3132431_0 ATPase (AAA K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004797 420.0
TLS2_k127_3132431_1 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000225 223.0
TLS2_k127_3132431_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000113 171.0
TLS2_k127_3135514_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 6.46e-300 961.0
TLS2_k127_3135514_1 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 7.469e-237 740.0
TLS2_k127_3135514_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 9.827e-200 632.0
TLS2_k127_3135514_3 Protein of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 528.0
TLS2_k127_3135514_4 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 391.0
TLS2_k127_3135514_5 hydrolase of the alpha beta superfamily K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 351.0
TLS2_k127_3135514_6 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 321.0
TLS2_k127_3135514_7 serine acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 286.0
TLS2_k127_3135514_8 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000002025 243.0
TLS2_k127_3135514_9 GYD domain - - - 0.00000000000000000000000000000001022 128.0
TLS2_k127_3167642_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 9.834e-270 836.0
TLS2_k127_3167642_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.055e-244 806.0
TLS2_k127_3167642_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 370.0
TLS2_k127_3167642_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 328.0
TLS2_k127_3167642_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000000000000000006494 198.0
TLS2_k127_3167642_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000000000000000000000001674 168.0
TLS2_k127_3167642_6 PFAM sigma-54 factor interaction domain-containing protein K07715 - - 0.00009947 54.0
TLS2_k127_3176472_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 584.0
TLS2_k127_3176472_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 541.0
TLS2_k127_3176472_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 343.0
TLS2_k127_3176472_3 transcriptional - - - 0.00000000000000000000000000000000000000000000000000000000000000000002829 250.0
TLS2_k127_3176472_4 Uncharacterised protein family (UPF0262) - - - 0.000000000000000000000000000000000000000000000000000000002086 205.0
TLS2_k127_3176472_5 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000006719 192.0
TLS2_k127_3176472_6 protein possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000000000000008947 183.0
TLS2_k127_3176472_7 Protein of unknown function (DUF2948) - - - 0.000000000000000000000000004879 118.0
TLS2_k127_3180341_0 Glycosyl transferase family 2 K00721,K20534 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 389.0
TLS2_k127_3180341_1 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 373.0
TLS2_k127_3180341_2 GDP-mannose 4,6 dehydratase K19180 - 1.1.1.339 0.0000001618 57.0
TLS2_k127_3189126_0 Binding-protein-dependent transport system inner membrane component K02011 - - 1.06e-219 695.0
TLS2_k127_3189126_1 Aminotransferase class-III K00823 - 2.6.1.19 8.341e-202 666.0
TLS2_k127_3189126_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 563.0
TLS2_k127_3189126_3 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009499 415.0
TLS2_k127_3189126_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 320.0
TLS2_k127_3189126_5 Aminotransferase class I and II K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006425 293.0
TLS2_k127_3189126_6 Glycosyl transferase 4-like domain - - - 0.00000000000000000000001922 114.0
TLS2_k127_3189126_7 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000003781 113.0
TLS2_k127_3189126_8 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000008722 109.0
TLS2_k127_3189126_9 - - - - 0.00000000000000000001353 106.0
TLS2_k127_3200873_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 2.635e-229 727.0
TLS2_k127_3200873_1 deoxyguanosinetriphosphate triphosphohydrolase-like protein K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 494.0
TLS2_k127_3200873_2 Belongs to the HesB IscA family K13628,K15724 - - 0.0000000000000000000000000000000002583 135.0
TLS2_k127_3200873_3 Sporulation related domain - - - 0.00000000000000006831 94.0
TLS2_k127_3200873_4 - - - - 0.0000000000001835 78.0
TLS2_k127_3206690_0 Peptidase family M20/M25/M40 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 620.0
TLS2_k127_3206690_1 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 418.0
TLS2_k127_3206690_10 - - - - 0.0002117 51.0
TLS2_k127_3206690_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 355.0
TLS2_k127_3206690_3 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005259 285.0
TLS2_k127_3206690_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily K15270 - - 0.0000000000000000000000000000000000000000000000000000000000003015 222.0
TLS2_k127_3206690_5 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.000000000000000000000000000000000000000000000000000000003526 207.0
TLS2_k127_3206690_6 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000004747 199.0
TLS2_k127_3206690_7 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000006187 151.0
TLS2_k127_3206690_8 TadE-like protein - - - 0.000000001116 67.0
TLS2_k127_3206690_9 TadE-like protein - - - 0.00002192 52.0
TLS2_k127_321292_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008803 507.0
TLS2_k127_321292_1 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 453.0
TLS2_k127_321292_2 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 375.0
TLS2_k127_321292_3 Peptidase family S49 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 317.0
TLS2_k127_321292_4 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 283.0
TLS2_k127_321292_5 Methyltransferase small domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000148 257.0
TLS2_k127_321292_6 Putative prokaryotic signal transducing protein - - - 0.00000000000008403 83.0
TLS2_k127_321292_7 - - - - 0.00002072 49.0
TLS2_k127_321292_8 - - - - 0.0006574 46.0
TLS2_k127_3228413_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 512.0
TLS2_k127_3228413_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 386.0
TLS2_k127_3228413_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 291.0
TLS2_k127_3228413_3 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008184 253.0
TLS2_k127_3228413_4 Riboflavin synthase alpha chain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000004192 237.0
TLS2_k127_3228413_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000006474 168.0
TLS2_k127_3228413_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000006805 152.0
TLS2_k127_3228413_7 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000362 135.0
TLS2_k127_3228413_8 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000002873 89.0
TLS2_k127_3228413_9 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000005648 77.0
TLS2_k127_322896_0 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 468.0
TLS2_k127_322896_1 Phosphonate ABC transporter K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 342.0
TLS2_k127_322896_2 LysR substrate binding domain - - - 0.00000000000000000000002028 101.0
TLS2_k127_325454_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 4.591e-274 870.0
TLS2_k127_325454_1 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 501.0
TLS2_k127_325454_10 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000001559 134.0
TLS2_k127_325454_11 transcriptional regulator K07726 - - 0.0000000000000000000000000004672 124.0
TLS2_k127_325454_12 DNA-binding transcription factor activity - - - 0.0000000000000000000000009832 110.0
TLS2_k127_325454_13 Protein of unknown function (DUF1153) - - - 0.0000000000000002949 84.0
TLS2_k127_325454_14 Protein of unknown function (DUF1153) - - - 0.000000000000002679 81.0
TLS2_k127_325454_15 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000006692 81.0
TLS2_k127_325454_16 Domain of unknown function (DUF4279) - - - 0.0000000000003603 78.0
TLS2_k127_325454_17 Belongs to the ompA family - - - 0.000000009442 61.0
TLS2_k127_325454_2 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 342.0
TLS2_k127_325454_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004334 342.0
TLS2_k127_325454_4 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000006314 229.0
TLS2_k127_325454_5 binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000000000000000000000000000000539 217.0
TLS2_k127_325454_6 dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000003783 215.0
TLS2_k127_325454_8 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000007001 157.0
TLS2_k127_325454_9 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000001072 159.0
TLS2_k127_3258562_0 FAD binding domain - - - 3.083e-202 643.0
TLS2_k127_3258562_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 563.0
TLS2_k127_3258562_2 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 535.0
TLS2_k127_3258562_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 334.0
TLS2_k127_3258562_4 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0000000000000000000000000000000000000000000000000000000000000001326 229.0
TLS2_k127_3258562_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000003006 214.0
TLS2_k127_3258562_6 Transcriptional regulator - - - 0.000000000000000000000001085 113.0
TLS2_k127_3258562_7 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000001524 119.0
TLS2_k127_3288564_0 - - - - 5.3e-199 657.0
TLS2_k127_3288564_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000778 442.0
TLS2_k127_3288564_10 - - - - 0.000008955 55.0
TLS2_k127_3288564_11 - - - - 0.0006324 48.0
TLS2_k127_3288564_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 452.0
TLS2_k127_3288564_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008578 440.0
TLS2_k127_3288564_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000146 274.0
TLS2_k127_3288564_5 Pectate lyase superfamily protein - - - 0.00000000000000000000000000000000000000006109 170.0
TLS2_k127_3288564_6 - - - - 0.000000000000000000000000000000000005034 138.0
TLS2_k127_3288564_7 Protein of unknown function (DUF2793) - - - 0.000000000000000000000000000003988 137.0
TLS2_k127_3288564_8 - - - - 0.00000000000000000000000000002747 123.0
TLS2_k127_3288564_9 Sel1-like repeats. K07126 - - 0.000007013 57.0
TLS2_k127_3319656_0 Uncharacterized protein family (UPF0051) K09014 - - 1.477e-260 808.0
TLS2_k127_3319656_1 Acyl-CoA dehydrogenase, N-terminal domain K00252 - 1.3.8.6 5.807e-224 700.0
TLS2_k127_3319656_10 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 286.0
TLS2_k127_3319656_11 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000302 273.0
TLS2_k127_3319656_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007567 276.0
TLS2_k127_3319656_13 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001601 279.0
TLS2_k127_3319656_14 DSBA-like thioredoxin domain K14584 - 5.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000006367 245.0
TLS2_k127_3319656_15 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000000000000000000000005005 217.0
TLS2_k127_3319656_16 lytic transglycosylase activity - - - 0.00000000000000000000000000000000000000000000000000000002465 201.0
TLS2_k127_3319656_17 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000001078 190.0
TLS2_k127_3319656_18 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000000747 183.0
TLS2_k127_3319656_19 Ferredoxin K04755 - - 0.00000000000000000000000000000000000000000000002524 173.0
TLS2_k127_3319656_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 550.0
TLS2_k127_3319656_20 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000004655 173.0
TLS2_k127_3319656_21 Iron-sulfur cluster assembly protein - - - 0.00000000000000000000000000000000000000001161 164.0
TLS2_k127_3319656_22 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000168 153.0
TLS2_k127_3319656_23 MarR family - - - 0.000000000000000000000000000000000000001565 154.0
TLS2_k127_3319656_24 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000009066 144.0
TLS2_k127_3319656_25 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000004268 148.0
TLS2_k127_3319656_26 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000002212 133.0
TLS2_k127_3319656_27 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000003186 111.0
TLS2_k127_3319656_28 ThiF family - - - 0.000000000000000000000007388 115.0
TLS2_k127_3319656_29 Thioesterase-like superfamily K07107 - - 0.00000000000000002013 95.0
TLS2_k127_3319656_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006155 499.0
TLS2_k127_3319656_4 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 459.0
TLS2_k127_3319656_5 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 415.0
TLS2_k127_3319656_6 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 388.0
TLS2_k127_3319656_7 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 381.0
TLS2_k127_3319656_8 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009332 377.0
TLS2_k127_3319656_9 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 296.0
TLS2_k127_3324369_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 6.309e-266 834.0
TLS2_k127_3324369_1 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 527.0
TLS2_k127_3324369_10 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003116 262.0
TLS2_k127_3324369_11 ABC 3 transport family K09816 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005488 265.0
TLS2_k127_3324369_12 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000003511 220.0
TLS2_k127_3324369_13 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000001102 230.0
TLS2_k127_3324369_14 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000009966 213.0
TLS2_k127_3324369_15 Belongs to the Fur family K09823 - - 0.0000000000000000000000000000000000000000000000000000003495 199.0
TLS2_k127_3324369_16 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000000000000000000000000000000009367 207.0
TLS2_k127_3324369_17 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000002324 207.0
TLS2_k127_3324369_18 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000002248 188.0
TLS2_k127_3324369_19 Histidine kinase - - - 0.000000000000000000000000000000000000000004485 158.0
TLS2_k127_3324369_2 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 451.0
TLS2_k127_3324369_20 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000002553 143.0
TLS2_k127_3324369_21 - - - - 0.0000000000000000000000000002834 122.0
TLS2_k127_3324369_22 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000002808 130.0
TLS2_k127_3324369_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 436.0
TLS2_k127_3324369_4 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005373 432.0
TLS2_k127_3324369_5 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 426.0
TLS2_k127_3324369_6 Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system K02074,K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000392 312.0
TLS2_k127_3324369_7 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 308.0
TLS2_k127_3324369_8 COG0475 Kef-type K transport systems, membrane components K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 310.0
TLS2_k127_3324369_9 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002593 271.0
TLS2_k127_3336250_0 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 452.0
TLS2_k127_3336250_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 380.0
TLS2_k127_3336250_2 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 354.0
TLS2_k127_3336250_3 RNA polymerase sigma K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002905 265.0
TLS2_k127_3336250_4 - - - - 0.00000000000334 75.0
TLS2_k127_3336250_5 - - - - 0.0001133 44.0
TLS2_k127_3337189_0 single-stranded-DNA-specific exonuclease recJ K07462 - - 2.393e-203 650.0
TLS2_k127_3337189_1 Aminotransferase K14261 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 598.0
TLS2_k127_3337189_10 Putative FMN-binding domain K07734 - - 0.000000000000000000000000000000000000000000000000000000000000000000002889 241.0
TLS2_k127_3337189_11 Phospholipid N-methyltransferase K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000416 183.0
TLS2_k127_3337189_2 ABC transporter, substrate-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 597.0
TLS2_k127_3337189_3 TrkA-C domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 586.0
TLS2_k127_3337189_4 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 549.0
TLS2_k127_3337189_5 COG1494 Fructose-1,6-bisphosphatase sedoheptulose 1,7-bisphosphatase and related proteins K11532 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 480.0
TLS2_k127_3337189_6 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 467.0
TLS2_k127_3337189_7 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 452.0
TLS2_k127_3337189_8 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 426.0
TLS2_k127_3337189_9 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004889 398.0
TLS2_k127_334866_0 Oxidoreductase - - - 1.251e-199 627.0
TLS2_k127_334866_1 Protein of unknown function (DUF993) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 581.0
TLS2_k127_334866_2 PFAM aldo keto reductase K05882 - 1.1.1.91 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 457.0
TLS2_k127_334866_3 Mandelate racemase muconate lactonizing enzyme K19802 - 5.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008381 413.0
TLS2_k127_334866_4 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 402.0
TLS2_k127_334866_5 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 400.0
TLS2_k127_334866_6 Belongs to the DapA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007064 346.0
TLS2_k127_334866_7 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006854 306.0
TLS2_k127_334866_8 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000552 245.0
TLS2_k127_334866_9 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000002127 198.0
TLS2_k127_3360649_0 chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 338.0
TLS2_k127_3360649_1 Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002973 248.0
TLS2_k127_3360649_2 Glycosyl transferase family 2 - - - 0.00000004591 61.0
TLS2_k127_3362758_0 transposase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 518.0
TLS2_k127_3362758_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006956 439.0
TLS2_k127_3362758_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 390.0
TLS2_k127_3362758_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0001084 52.0
TLS2_k127_3372057_0 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 527.0
TLS2_k127_3372057_1 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K01784,K03274 - 5.1.3.2,5.1.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 458.0
TLS2_k127_3372057_10 - - - - 0.0000000000000000000000000000000000005349 153.0
TLS2_k127_3372057_11 protein conserved in bacteria K09806 - - 0.00000000000000003315 85.0
TLS2_k127_3372057_12 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000007131 75.0
TLS2_k127_3372057_13 - - - - 0.0000000001151 75.0
TLS2_k127_3372057_2 Putative S-adenosyl-L-methionine-dependent methyltransferase K00574,K18164 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 338.0
TLS2_k127_3372057_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 327.0
TLS2_k127_3372057_4 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 316.0
TLS2_k127_3372057_5 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006951 292.0
TLS2_k127_3372057_6 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001575 274.0
TLS2_k127_3372057_7 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000004228 223.0
TLS2_k127_3372057_8 Glycosyl transferase family 21 K00720 - 2.4.1.80 0.00000000000000000000000000000000000000000000000000609 198.0
TLS2_k127_3372057_9 Belongs to the DapB family K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000006915 168.0
TLS2_k127_3385056_0 PFAM Extracellular ligand-binding receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 398.0
TLS2_k127_3385056_1 Aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 378.0
TLS2_k127_3385056_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 363.0
TLS2_k127_3385056_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 345.0
TLS2_k127_3385056_4 branched-chain amino acid K01995,K11957 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 301.0
TLS2_k127_3385056_5 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008824 248.0
TLS2_k127_3385056_6 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000001553 235.0
TLS2_k127_3385056_7 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000004396 166.0
TLS2_k127_3385056_8 - - - - 0.000000000000000000000000000000000002364 156.0
TLS2_k127_3385056_9 lactoylglutathione lyase activity - - - 0.000000006915 62.0
TLS2_k127_3385093_0 belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 423.0
TLS2_k127_3385093_1 Belongs to the thiolase family - - - 0.000000000000000000000000000000000001035 143.0
TLS2_k127_3385093_2 Phenylacetic acid catabolic protein - - - 0.00000000000000000000000000004644 135.0
TLS2_k127_3385093_3 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000002935 51.0
TLS2_k127_339252_0 Major Facilitator Superfamily - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 550.0
TLS2_k127_339252_1 VanW like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 511.0
TLS2_k127_339252_2 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 436.0
TLS2_k127_339252_3 ABC transporter substrate-binding protein PnrA-like K02058,K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 441.0
TLS2_k127_339252_4 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 378.0
TLS2_k127_339252_5 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 349.0
TLS2_k127_339252_6 ABC-type uncharacterized transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 315.0
TLS2_k127_339252_7 nuclear chromosome segregation - - - 0.000000000000000000000000001891 122.0
TLS2_k127_339252_8 (ABC) transporter K02056 - 3.6.3.17 0.0000000000000000000000001696 107.0
TLS2_k127_339252_9 Domain of unknown function (DUF4340) - - - 0.000000000000000000000002119 116.0
TLS2_k127_3423237_0 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 376.0
TLS2_k127_3423237_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005549 366.0
TLS2_k127_3423237_2 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 334.0
TLS2_k127_3423237_3 Amino acid ABC transporter ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003281 259.0
TLS2_k127_3423237_4 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004942 261.0
TLS2_k127_3423237_5 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000004887 81.0
TLS2_k127_343038_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008417 445.0
TLS2_k127_343038_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000003657 223.0
TLS2_k127_343038_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000001254 197.0
TLS2_k127_343038_3 PAS domain - - - 0.0000000000000000000000000000001091 130.0
TLS2_k127_343038_4 Protein conserved in bacteria K21600 - - 0.000000000000000000000000000008559 130.0
TLS2_k127_3439386_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 593.0
TLS2_k127_3439386_1 5-aminolevulinic acid synthase K00643 - 2.3.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 581.0
TLS2_k127_3439386_2 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 488.0
TLS2_k127_3439386_3 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 481.0
TLS2_k127_3439386_4 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000009215 237.0
TLS2_k127_3439386_5 Putative AphA-like transcriptional regulator - - - 0.000000000000000000000000000000000000000001202 165.0
TLS2_k127_3439386_6 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000725 149.0
TLS2_k127_3439386_7 SMI1-KNR4 cell-wall - - - 0.00005115 51.0
TLS2_k127_3440981_0 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008871 357.0
TLS2_k127_3440981_1 ADP-glyceromanno-heptose 6-epimerase activity K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000007404 266.0
TLS2_k127_3440981_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000005452 88.0
TLS2_k127_3499701_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004279 259.0
TLS2_k127_3499701_1 SapC - - - 0.000000000000000000000000000000000000000000000000000000000003703 217.0
TLS2_k127_3499701_2 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000000000000000000000000000000001199 223.0
TLS2_k127_3499701_3 helix_turn_helix, Lux Regulon K02479,K07684 - - 0.000000000000000000000000000000000000002453 156.0
TLS2_k127_3499701_4 - - - - 0.000000000000000000000000000000225 131.0
TLS2_k127_3499701_5 - - - - 0.000001808 57.0
TLS2_k127_356836_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 366.0
TLS2_k127_356836_1 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001475 271.0
TLS2_k127_356836_2 Acyl-CoA dehydrogenase, C-terminal domain K16047,K20942 - 1.14.14.12,1.14.14.27 0.000000000000000000000000000000000000000000000000000000000000005707 233.0
TLS2_k127_356836_3 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.00000000000000000000000000000000000000000000000000008659 189.0
TLS2_k127_356836_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000002875 173.0
TLS2_k127_356836_5 Flavodoxin-like fold - - - 0.00000000000000000000000000000000000000000005118 167.0
TLS2_k127_356836_6 Glycosyl transferases group 1 - - - 0.000000000000000000000008043 106.0
TLS2_k127_356836_7 amino acid ABC transporter K16961,K16962 - - 0.00000000000001412 83.0
TLS2_k127_3580715_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 463.0
TLS2_k127_3580715_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 447.0
TLS2_k127_3580715_2 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003248 283.0
TLS2_k127_3580715_3 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001811 254.0
TLS2_k127_3580715_4 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000000000009437 216.0
TLS2_k127_3580715_5 Protein of unknown function (DUF1428) - - - 0.000000000000000000000000000000000000000000000000000001176 194.0
TLS2_k127_3580715_6 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000005752 128.0
TLS2_k127_3604748_0 COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) K00336 - 1.6.5.3 4.168e-317 1005.0
TLS2_k127_3604748_1 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 3.627e-232 745.0
TLS2_k127_3604748_10 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00334,K03943 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000007367 226.0
TLS2_k127_3604748_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000002737 201.0
TLS2_k127_3604748_12 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000002869 201.0
TLS2_k127_3604748_13 GGDEF domain containing protein - - - 0.00000000000000000000000000000000000006051 164.0
TLS2_k127_3604748_14 Domain of unknown function (DUF4142) K08995 - - 0.000000000000007394 83.0
TLS2_k127_3604748_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 6.355e-229 714.0
TLS2_k127_3604748_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 1.666e-211 667.0
TLS2_k127_3604748_4 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 420.0
TLS2_k127_3604748_5 His Kinase A (phospho-acceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 354.0
TLS2_k127_3604748_6 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 314.0
TLS2_k127_3604748_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009677 291.0
TLS2_k127_3604748_8 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000003651 242.0
TLS2_k127_3604748_9 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000005974 218.0
TLS2_k127_3654372_0 CoA-transferase family III K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 517.0
TLS2_k127_3654372_1 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 300.0
TLS2_k127_3654372_10 TAP-like protein - - - 0.0000000000000000000002066 108.0
TLS2_k127_3654372_11 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000004817 99.0
TLS2_k127_3654372_12 Cytochrome c - - - 0.000000000000007162 78.0
TLS2_k127_3654372_2 Phospholipase/Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000007105 247.0
TLS2_k127_3654372_3 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000001005 241.0
TLS2_k127_3654372_4 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000001455 207.0
TLS2_k127_3654372_5 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000000000003822 214.0
TLS2_k127_3654372_6 DedA family - - - 0.0000000000000000000000000000000000000000000000000000000008832 207.0
TLS2_k127_3654372_7 endonuclease III K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000002364 206.0
TLS2_k127_3654372_8 bond formation protein, DsbB K03611 - - 0.0000000000000000000000000000000001947 140.0
TLS2_k127_3654372_9 FecR protein - - - 0.0000000000000000000000001715 114.0
TLS2_k127_3664871_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 5.119e-312 979.0
TLS2_k127_3664871_1 Amidohydrolase K07045 - - 2.706e-233 732.0
TLS2_k127_3664871_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 343.0
TLS2_k127_3664871_3 Extracellular liganD-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 307.0
TLS2_k127_3664871_4 Isochorismatase family K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000000000000000000000000003274 257.0
TLS2_k127_3664871_5 FCD - - - 0.00000000000000000000000000000000000000000000000000000002354 207.0
TLS2_k127_3664871_6 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000004737 174.0
TLS2_k127_3664871_7 Thioesterase-like superfamily - - - 0.0000000000000000000000000000001217 141.0
TLS2_k127_3664871_8 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.00000000000000000000000278 108.0
TLS2_k127_3664871_9 CO dehydrogenase flavoprotein C-terminal domain K13481 - 1.17.1.4 0.0000001463 60.0
TLS2_k127_3687110_0 NeuB family K01654 - 2.5.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 458.0
TLS2_k127_3687110_1 COG3980 Spore coat polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002676 254.0
TLS2_k127_3687110_2 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase K07257 - - 0.000000000000000000000000000000000000000000000000009864 195.0
TLS2_k127_3687110_3 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000003864 116.0
TLS2_k127_3687110_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845,K15681 - 5.4.3.8 0.000000000001287 76.0
TLS2_k127_3687110_5 pseudaminic acid biosynthesis-associated protein PseG - - - 0.00000105 61.0
TLS2_k127_3733966_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1299.0
TLS2_k127_3733966_1 transport system fused permease components - - - 2.99e-254 801.0
TLS2_k127_3733966_2 radical SAM domain protein K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008418 333.0
TLS2_k127_3733966_3 transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002834 243.0
TLS2_k127_3733966_4 PFAM Bacterial protein of - - - 0.00000000000000000000000000000000000000000000000000000000001353 212.0
TLS2_k127_3733966_5 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000006912 173.0
TLS2_k127_3733966_6 - - - - 0.0003677 49.0
TLS2_k127_3771616_0 COG1138 Cytochrome c biogenesis factor K02198 - - 3.581e-284 887.0
TLS2_k127_3771616_1 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 483.0
TLS2_k127_3771616_10 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.00000000000000000000000000000000000000005088 156.0
TLS2_k127_3771616_11 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.000000001235 61.0
TLS2_k127_3771616_2 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 306.0
TLS2_k127_3771616_3 COG1960 Acyl-CoA dehydrogenases K20035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 305.0
TLS2_k127_3771616_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003823 269.0
TLS2_k127_3771616_5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002975 258.0
TLS2_k127_3771616_6 branched-chain amino acid K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000002501 221.0
TLS2_k127_3771616_7 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000006951 221.0
TLS2_k127_3771616_8 Redoxin K02199 - - 0.0000000000000000000000000000000000000000001009 183.0
TLS2_k127_3771616_9 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000001598 171.0
TLS2_k127_3772231_0 Methionine synthase K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1180.0
TLS2_k127_3772231_1 transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 589.0
TLS2_k127_3772231_10 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 361.0
TLS2_k127_3772231_11 glycolate oxidase subunit GlcD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 343.0
TLS2_k127_3772231_12 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006933 344.0
TLS2_k127_3772231_13 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 325.0
TLS2_k127_3772231_14 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000004514 254.0
TLS2_k127_3772231_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000003713 199.0
TLS2_k127_3772231_16 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000000000000000000000005458 201.0
TLS2_k127_3772231_17 COG1309 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000004311 170.0
TLS2_k127_3772231_18 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.000000000000000000000000000000004186 141.0
TLS2_k127_3772231_19 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000001541 138.0
TLS2_k127_3772231_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 463.0
TLS2_k127_3772231_20 Peptidoglycan-binding domain 1 protein K02450,K03194,K08309 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000002302 107.0
TLS2_k127_3772231_21 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000193 93.0
TLS2_k127_3772231_22 Caspase domain - - - 0.000000000000429 77.0
TLS2_k127_3772231_3 COG1960 Acyl-CoA dehydrogenases K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 456.0
TLS2_k127_3772231_4 Homocysteine S-methyltransferase K00544,K00548 - 2.1.1.13,2.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 445.0
TLS2_k127_3772231_5 OpgC protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007551 413.0
TLS2_k127_3772231_6 Methylenetetrahydrofolate reductase K00297 GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 419.0
TLS2_k127_3772231_7 arsR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 389.0
TLS2_k127_3772231_8 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 381.0
TLS2_k127_3772231_9 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 394.0
TLS2_k127_3795571_0 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.586e-230 721.0
TLS2_k127_3795571_1 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 1.6e-217 683.0
TLS2_k127_3795571_2 glutathione-disulfide reductase activity K00383,K04283 - 1.8.1.12,1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 548.0
TLS2_k127_3795571_3 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008233 351.0
TLS2_k127_3795571_4 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 293.0
TLS2_k127_3795571_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000471 209.0
TLS2_k127_3795571_6 - - - - 0.000000000000000000000000000000000002241 159.0
TLS2_k127_3795571_7 - - - - 0.00000000000000000000000001774 127.0
TLS2_k127_3795571_8 DUF218 domain - - - 0.00005418 46.0
TLS2_k127_3821569_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1105.0
TLS2_k127_3821569_1 Malic enzyme K00029 - 1.1.1.40 0.0 1050.0
TLS2_k127_3821569_10 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000000000000000000000000003686 207.0
TLS2_k127_3821569_11 Belongs to the UbiD family K16874 - - 0.0000000000000000000000000000000000000000000000000003233 205.0
TLS2_k127_3821569_12 Belongs to the UPF0354 family - - - 0.0000000000000000000000000000000000000004819 160.0
TLS2_k127_3821569_13 nuclease - - - 0.00000000000000000000000000000004563 130.0
TLS2_k127_3821569_14 Serine aminopeptidase, S33 - - - 0.0000000000000000000000005133 107.0
TLS2_k127_3821569_15 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.000000000000000000004741 108.0
TLS2_k127_3821569_16 Ubiquinol-cytochrome C reductase - - - 0.00000000000000001503 83.0
TLS2_k127_3821569_17 Cupin domain - - - 0.0000000000000001144 86.0
TLS2_k127_3821569_18 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.1.163,2.1.1.201 0.00000000000002953 83.0
TLS2_k127_3821569_19 Protein of unknown function (DUF1674) - - - 0.000000002209 62.0
TLS2_k127_3821569_2 Nuclease-related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005737 526.0
TLS2_k127_3821569_22 PFAM regulatory protein, MarR - - - 0.0008456 51.0
TLS2_k127_3821569_3 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 421.0
TLS2_k127_3821569_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 415.0
TLS2_k127_3821569_5 Belongs to the UbiD family K03182 - 4.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 385.0
TLS2_k127_3821569_6 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005415 267.0
TLS2_k127_3821569_7 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004815 254.0
TLS2_k127_3821569_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006442 238.0
TLS2_k127_3821569_9 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000016 247.0
TLS2_k127_3829354_0 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 339.0
TLS2_k127_3829354_1 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008735 229.0
TLS2_k127_3829354_2 Acetyltransferase K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000046 203.0
TLS2_k127_3829354_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000001291 87.0
TLS2_k127_3829354_4 Transcriptional regulator, Crp Fnr family - - - 0.0000000000000002905 79.0
TLS2_k127_3829354_5 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000008418 59.0
TLS2_k127_3862375_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 457.0
TLS2_k127_3862375_1 Histidine kinase K07638 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 430.0
TLS2_k127_3862375_2 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 323.0
TLS2_k127_3862375_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07659 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 261.0
TLS2_k127_3862375_4 transcriptional - - - 0.0000000000000000000000000000000000000000000003581 171.0
TLS2_k127_3862375_5 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000271 143.0
TLS2_k127_3862375_6 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000003851 143.0
TLS2_k127_3867808_0 PFAM extracellular solute-binding protein family 5 K02035 - - 4.699e-213 676.0
TLS2_k127_3867808_1 Belongs to the ABC transporter superfamily K02031,K02032 - - 1.796e-204 664.0
TLS2_k127_3867808_10 Belongs to the bacterial solute-binding protein 3 family K01713 - 4.2.1.51,4.2.1.91 0.000000000000000000000000000000000000000000000000000000000000000007183 244.0
TLS2_k127_3867808_11 Phosphohydrolase - - - 0.000000000000000000000000000000000003511 145.0
TLS2_k127_3867808_12 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000001324 128.0
TLS2_k127_3867808_13 aconitate hydratase K01681 - 4.2.1.3 0.000002515 51.0
TLS2_k127_3867808_2 Belongs to the amidase family K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 478.0
TLS2_k127_3867808_3 inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 379.0
TLS2_k127_3867808_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 355.0
TLS2_k127_3867808_5 Belongs to the iron ascorbate-dependent oxidoreductase family K21815 - 1.13.12.19,1.14.11.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 337.0
TLS2_k127_3867808_6 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 342.0
TLS2_k127_3867808_7 ABC-type amino acid transport system permease component K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004331 280.0
TLS2_k127_3867808_8 Alkylhydroperoxidase AhpD family core domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000181 246.0
TLS2_k127_3867808_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000003894 246.0
TLS2_k127_3872575_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1316.0
TLS2_k127_3872575_1 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005197 498.0
TLS2_k127_3872575_10 Transposase - - - 0.00000000000000000000006354 105.0
TLS2_k127_3872575_11 Ring hydroxylating subunit beta family protein 1 - - - 0.0000000000000000000272 106.0
TLS2_k127_3872575_12 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000001234 73.0
TLS2_k127_3872575_13 - - - - 0.0000133 54.0
TLS2_k127_3872575_2 Biotin carboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 334.0
TLS2_k127_3872575_3 Rieske [2Fe-2S] domain K22325 - 1.14.15.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000002428 275.0
TLS2_k127_3872575_4 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000006154 237.0
TLS2_k127_3872575_5 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.00000000000000000000000000000000000000000000000004552 188.0
TLS2_k127_3872575_6 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000001019 165.0
TLS2_k127_3872575_7 Leucine Rich repeat - - - 0.0000000000000000000000000000002289 137.0
TLS2_k127_3872575_8 PIN domain - - - 0.00000000000000000000000000001776 125.0
TLS2_k127_3872575_9 transcription regulator, contains HTH domain (MarR family) - - - 0.000000000000000000000002101 109.0
TLS2_k127_3889709_0 Belongs to the thiolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 462.0
TLS2_k127_3889709_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000009676 246.0
TLS2_k127_3889709_2 diguanylate cyclase - - - 0.000000000000000000000000003309 126.0
TLS2_k127_3890458_0 dioxygenase, alpha - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007544 531.0
TLS2_k127_3890458_1 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 512.0
TLS2_k127_3890458_2 tRNA synthetases class I (C) catalytic domain K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005088 445.0
TLS2_k127_3890458_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001632 267.0
TLS2_k127_3890458_4 Ring hydroxylating beta subunit K16303 - 1.14.12.25 0.00000000000000000000000000000000000000003755 160.0
TLS2_k127_3902955_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 3.443e-196 623.0
TLS2_k127_3902955_1 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 475.0
TLS2_k127_3902955_2 L-phenylalanine transmembrane transporter activity K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 349.0
TLS2_k127_3902955_3 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005548 284.0
TLS2_k127_3902955_4 ABC transporter, ATP-binding protein K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004635 278.0
TLS2_k127_3902955_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005252 274.0
TLS2_k127_3904464_0 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 317.0
TLS2_k127_3904464_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 297.0
TLS2_k127_3904464_2 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000003273 265.0
TLS2_k127_3904464_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000001178 191.0
TLS2_k127_3904464_4 ABC-type tungstate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000003349 184.0
TLS2_k127_3905350_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 4.722e-238 745.0
TLS2_k127_3905350_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 581.0
TLS2_k127_3905350_10 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000000000000000109 195.0
TLS2_k127_3905350_11 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000001038 186.0
TLS2_k127_3905350_12 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000001465 174.0
TLS2_k127_3905350_13 Staphylococcal nuclease homologue - - - 0.000000000000000000000000000000000000000000000006413 181.0
TLS2_k127_3905350_14 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000000000000000001028 168.0
TLS2_k127_3905350_15 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000000000000000009076 143.0
TLS2_k127_3905350_16 tRNA wobble adenosine to inosine editing - - - 0.000000000000000000000000000000000006446 155.0
TLS2_k127_3905350_17 RDD family - - - 0.0000004912 59.0
TLS2_k127_3905350_19 RDD family - - - 0.0001035 53.0
TLS2_k127_3905350_2 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 441.0
TLS2_k127_3905350_3 Di-haem oxidoreductase, putative peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003268 387.0
TLS2_k127_3905350_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008191 329.0
TLS2_k127_3905350_5 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 333.0
TLS2_k127_3905350_6 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 306.0
TLS2_k127_3905350_7 transcriptional regulator K07736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002965 243.0
TLS2_k127_3905350_8 Domain of unknown function (4846) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004818 252.0
TLS2_k127_3905350_9 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000000000000002085 239.0
TLS2_k127_3930299_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1354.0
TLS2_k127_3936356_0 DNA polymerase X family K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 589.0
TLS2_k127_3936356_1 Periplasmic binding protein domain K01999,K11959 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 469.0
TLS2_k127_3936356_10 Belongs to the binding-protein-dependent transport system permease family K01997,K11960 - - 0.00000000000000237 78.0
TLS2_k127_3936356_2 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 450.0
TLS2_k127_3936356_3 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 415.0
TLS2_k127_3936356_4 ABC-type Fe3 transport system permease component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 372.0
TLS2_k127_3936356_5 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 335.0
TLS2_k127_3936356_6 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 294.0
TLS2_k127_3936356_7 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 289.0
TLS2_k127_3936356_8 ornithine cyclodeaminase mu-crystallin K19244 - 1.4.1.1 0.00000000000000000000000000000000000000000000004063 191.0
TLS2_k127_3936356_9 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000005738 119.0
TLS2_k127_3947164_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 516.0
TLS2_k127_3947164_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009937 471.0
TLS2_k127_3947164_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 394.0
TLS2_k127_3947164_3 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 322.0
TLS2_k127_3947164_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 299.0
TLS2_k127_3947164_5 transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 299.0
TLS2_k127_3947164_6 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000004026 228.0
TLS2_k127_3947164_7 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.0000000000000000000002317 105.0
TLS2_k127_3955708_0 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes K00164 - 1.2.4.2 0.0 1300.0
TLS2_k127_3955708_1 Belongs to the ABC transporter superfamily K13896 - - 3.338e-225 729.0
TLS2_k127_3955708_10 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 529.0
TLS2_k127_3955708_11 transport system, permease component K13895 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007269 503.0
TLS2_k127_3955708_12 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 467.0
TLS2_k127_3955708_13 transport system, permease component K13894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 474.0
TLS2_k127_3955708_14 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009505 412.0
TLS2_k127_3955708_15 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 387.0
TLS2_k127_3955708_16 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 344.0
TLS2_k127_3955708_17 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 343.0
TLS2_k127_3955708_18 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 345.0
TLS2_k127_3955708_19 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 339.0
TLS2_k127_3955708_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 1.927e-212 664.0
TLS2_k127_3955708_20 PFAM Alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 306.0
TLS2_k127_3955708_21 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002309 282.0
TLS2_k127_3955708_22 NQR2, RnfD, RnfE family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006141 272.0
TLS2_k127_3955708_23 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000003776 247.0
TLS2_k127_3955708_24 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000006309 211.0
TLS2_k127_3955708_25 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000001024 206.0
TLS2_k127_3955708_26 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000008557 175.0
TLS2_k127_3955708_27 Bacterial protein of unknown function (DUF898) - - - 0.0000000000000000000000000000000000000000009824 170.0
TLS2_k127_3955708_28 Cytochrome c, class I K08738 - - 0.00000000000000000000000000000000000000002915 162.0
TLS2_k127_3955708_29 Peptidase family M48 - - - 0.000000000000000000000000000000000002755 158.0
TLS2_k127_3955708_3 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 2.193e-203 669.0
TLS2_k127_3955708_30 Domain of Unknown Function (DUF350) K08989 - - 0.00000000000000000000000000000001034 133.0
TLS2_k127_3955708_31 - - - - 0.0000000000000000000000000000008066 128.0
TLS2_k127_3955708_32 epimerase - - - 0.000000000000000000000000001426 130.0
TLS2_k127_3955708_4 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 1.752e-202 647.0
TLS2_k127_3955708_5 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 607.0
TLS2_k127_3955708_6 Uncharacterized protein conserved in bacteria (DUF2330) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005352 556.0
TLS2_k127_3955708_7 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 557.0
TLS2_k127_3955708_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 522.0
TLS2_k127_3955708_9 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 527.0
TLS2_k127_3955849_0 PAS PAC domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 618.0
TLS2_k127_3955849_1 Aspartate tyrosine aromatic aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 582.0
TLS2_k127_3955849_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 561.0
TLS2_k127_3955849_3 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 500.0
TLS2_k127_3955849_4 reductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 441.0
TLS2_k127_3955849_5 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000000000000129 153.0
TLS2_k127_3960772_0 Formate dehydrogenase subunit alpha - - - 0.0 1422.0
TLS2_k127_3960772_1 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 3.694e-255 796.0
TLS2_k127_3960772_10 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 383.0
TLS2_k127_3960772_11 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005159 333.0
TLS2_k127_3960772_12 belongs to the carbohydrate kinase PfkB family K16370 - 2.7.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 325.0
TLS2_k127_3960772_13 Glucokinase K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 323.0
TLS2_k127_3960772_14 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005615 326.0
TLS2_k127_3960772_15 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 311.0
TLS2_k127_3960772_16 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003848 274.0
TLS2_k127_3960772_17 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000003646 252.0
TLS2_k127_3960772_18 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000004137 266.0
TLS2_k127_3960772_19 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000002363 224.0
TLS2_k127_3960772_2 AMP-binding enzyme C-terminal domain K00666 - - 3.618e-241 757.0
TLS2_k127_3960772_20 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000005999 219.0
TLS2_k127_3960772_21 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000005898 217.0
TLS2_k127_3960772_22 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.00000000000000000000000000000000000000000000000000001002 199.0
TLS2_k127_3960772_23 Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000004419 209.0
TLS2_k127_3960772_24 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000008552 183.0
TLS2_k127_3960772_25 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000116 179.0
TLS2_k127_3960772_26 Transposase K07491 - - 0.000000000000000000000000000000000000000000001099 169.0
TLS2_k127_3960772_27 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000202 176.0
TLS2_k127_3960772_28 MAPEG family - - - 0.00000000000000000000000000000000000000000002196 167.0
TLS2_k127_3960772_29 Protein of unknown function (DUF952) - - - 0.00000000000000000000000000000000000000000006796 167.0
TLS2_k127_3960772_3 Dehydrogenase K00122 - 1.17.1.9 2.24e-239 779.0
TLS2_k127_3960772_30 anti-sigma factor K07167 - - 0.000000000000000000000000000000000000000004244 171.0
TLS2_k127_3960772_32 acyl carrier protein K02078 - - 0.0000000000806 70.0
TLS2_k127_3960772_4 Adenylate cyclase - - - 1.4e-229 723.0
TLS2_k127_3960772_5 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 623.0
TLS2_k127_3960772_6 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005892 492.0
TLS2_k127_3960772_7 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 476.0
TLS2_k127_3960772_8 Belongs to the beta-ketoacyl-ACP synthases family K14660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009054 427.0
TLS2_k127_3960772_9 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007676 414.0
TLS2_k127_4007772_0 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 381.0
TLS2_k127_4007772_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 325.0
TLS2_k127_4007772_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 299.0
TLS2_k127_4007772_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 308.0
TLS2_k127_4007772_4 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000138 265.0
TLS2_k127_4007772_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000006394 250.0
TLS2_k127_4007772_6 lactoylglutathione lyase activity K08234 - - 0.0000000000000000000000000000000000000000000000005546 184.0
TLS2_k127_4007772_7 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.0000000000000003354 86.0
TLS2_k127_4010364_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008694 445.0
TLS2_k127_4010364_1 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 432.0
TLS2_k127_4010364_2 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001453 287.0
TLS2_k127_4010364_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001244 252.0
TLS2_k127_4022639_0 Belongs to the aldehyde dehydrogenase family K00151 - 1.2.1.60 1.313e-227 724.0
TLS2_k127_4022639_1 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 516.0
TLS2_k127_4022639_10 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000004108 104.0
TLS2_k127_4022639_11 Thioesterase-like superfamily K01075 - 3.1.2.23 0.00000000000000000000002128 104.0
TLS2_k127_4022639_12 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000003856 111.0
TLS2_k127_4022639_13 Domain of unknown function (DUF1330) - - - 0.0000000000000000000007972 98.0
TLS2_k127_4022639_14 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000007652 66.0
TLS2_k127_4022639_15 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000002713 57.0
TLS2_k127_4022639_2 3,4-dihydroxyphenylacetate 2,3-dioxygenase K00455 - 1.13.11.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007081 424.0
TLS2_k127_4022639_3 PFAM class II aldolase adducin family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 374.0
TLS2_k127_4022639_4 fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 359.0
TLS2_k127_4022639_5 Trap-type c4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 300.0
TLS2_k127_4022639_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009054 246.0
TLS2_k127_4022639_7 O-methyltransferase K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000008351 206.0
TLS2_k127_4022639_8 5-carboxymethyl-2-hydroxymuconate isomerase K01826 - 5.3.3.10 0.000000000000000000000000000000004459 133.0
TLS2_k127_4022639_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000001224 128.0
TLS2_k127_4038085_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007581 420.0
TLS2_k127_4038085_1 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 368.0
TLS2_k127_4038085_2 ATPases associated with a variety of cellular activities K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 361.0
TLS2_k127_4038085_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.00000000000000000000000000000000000000000000000000000000000000007359 235.0
TLS2_k127_4038085_4 Mo-co oxidoreductase dimerisation domain K00387 - 1.8.3.1 0.000000000000000000000000000000000000000000000000000000001821 203.0
TLS2_k127_4038085_5 ABC-type transport auxiliary lipoprotein component K18480 - - 0.000000000000000000000000000000000000000000000002337 181.0
TLS2_k127_4038085_6 MlaD protein K02067,K06192 - - 0.0000000000000000000000000000000000000000000007252 177.0
TLS2_k127_4038085_7 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000005227 137.0
TLS2_k127_4038085_8 cytochrome - - - 0.00000000000000000000001813 106.0
TLS2_k127_4038085_9 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.0000000000000005708 81.0
TLS2_k127_4041737_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 3.557e-202 641.0
TLS2_k127_4041737_1 Glutathione S-transferase, C-terminal domain K07393 - 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007413 511.0
TLS2_k127_4041737_10 Belongs to the SOS response-associated peptidase family - - - 0.00003359 47.0
TLS2_k127_4041737_2 Glutathione S-transferase K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 403.0
TLS2_k127_4041737_3 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000178 289.0
TLS2_k127_4041737_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001574 274.0
TLS2_k127_4041737_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000002682 243.0
TLS2_k127_4041737_6 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000001064 216.0
TLS2_k127_4041737_7 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000001212 174.0
TLS2_k127_4041737_8 Phosphodiester glycosidase - - - 0.00000000000000000000000000000183 133.0
TLS2_k127_4041737_9 - - - - 0.0000000000000005944 90.0
TLS2_k127_4049296_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 1.2e-278 872.0
TLS2_k127_4049296_1 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 381.0
TLS2_k127_4049296_2 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 359.0
TLS2_k127_4049296_3 overlaps another CDS with the same product name - - - 0.0000000000000000001542 104.0
TLS2_k127_4065419_0 Protein conserved in bacteria K07793 - - 8.832e-247 779.0
TLS2_k127_4065419_1 Mandelate Racemase Muconate Lactonizing - - - 4.747e-221 709.0
TLS2_k127_4065419_10 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000000000000000007092 172.0
TLS2_k127_4065419_2 Dihydrodipicolinate synthetase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 543.0
TLS2_k127_4065419_3 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006448 519.0
TLS2_k127_4065419_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 486.0
TLS2_k127_4065419_5 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 441.0
TLS2_k127_4065419_6 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 405.0
TLS2_k127_4065419_7 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 299.0
TLS2_k127_4065419_8 PFAM regulatory protein TetR - - - 0.000000000000000000000000000000000000000000000000000000000000000000005121 245.0
TLS2_k127_4065419_9 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000006873 256.0
TLS2_k127_4072174_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 4.96e-234 735.0
TLS2_k127_4072174_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006991 332.0
TLS2_k127_4072174_2 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 327.0
TLS2_k127_4072174_3 threonine efflux protein - - - 0.0000000000000000000000000000000000000006266 159.0
TLS2_k127_4072174_4 Protein of unknown function DUF86 - - - 0.00000000000000000001301 96.0
TLS2_k127_4072174_5 PFAM DNA polymerase, beta domain protein region K07075 - - 0.0000000000000000724 85.0
TLS2_k127_4072174_6 TPR repeat - - - 0.000000000007872 72.0
TLS2_k127_4076453_0 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 1.282e-274 861.0
TLS2_k127_4076453_1 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 501.0
TLS2_k127_4076453_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006293 473.0
TLS2_k127_4076453_3 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 436.0
TLS2_k127_4076453_4 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 399.0
TLS2_k127_4076453_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 353.0
TLS2_k127_4076453_6 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 310.0
TLS2_k127_4076802_0 AMP-binding enzyme C-terminal domain K00666 - - 9.597e-250 786.0
TLS2_k127_4076802_1 Bacteriophage head to tail connecting protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 606.0
TLS2_k127_4076802_10 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000002299 94.0
TLS2_k127_4076802_11 - - - - 0.000000000000000002346 90.0
TLS2_k127_4076802_12 - - - - 0.000000001023 69.0
TLS2_k127_4076802_13 - - - - 0.000001925 58.0
TLS2_k127_4076802_2 oxidoreductase activity K11089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 559.0
TLS2_k127_4076802_3 Peptidase S24-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 304.0
TLS2_k127_4076802_4 Histidine kinase K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000005048 242.0
TLS2_k127_4076802_5 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000000000000000000000000000000000000000001458 211.0
TLS2_k127_4076802_6 transcription regulator containing HTH domain K18831 - - 0.00000000000000000000000000000000000000000000000008171 186.0
TLS2_k127_4076802_7 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system - - - 0.000000000000000000000000000000000000000006433 157.0
TLS2_k127_4076802_8 - - - - 0.000000000000000000000000000001348 132.0
TLS2_k127_4076802_9 transcriptional regulator - - - 0.0000000000000000000000000007772 117.0
TLS2_k127_4078_0 Class II Aldolase and Adducin N-terminal domain - - - 1.954e-200 634.0
TLS2_k127_4078_1 Psort location CytoplasmicMembrane, score 10.00 - - - 0.00000000000000000000000000000000000000000000000005847 186.0
TLS2_k127_4078_2 Branched-chain amino acid transport protein (AzlD) - - - 0.00000000003757 67.0
TLS2_k127_4078_3 Conserved protein containing a Zn-ribbon-like motif possibly RNA-binding - - - 0.000000012 60.0
TLS2_k127_4095209_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1397.0
TLS2_k127_4095209_1 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 3.005e-246 775.0
TLS2_k127_4095209_10 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000002485 149.0
TLS2_k127_4095209_11 Cytochrome c K08738 - - 0.00000000000000000000000001085 114.0
TLS2_k127_4095209_12 Protein of unknown function (DUF3305) - - - 0.0000000000000000000000002709 113.0
TLS2_k127_4095209_13 Protein of unknown function (DUF3108) - - - 0.0000000000000000000002066 108.0
TLS2_k127_4095209_14 Protein of unknown function (DUF3306) - - - 0.0000000000000000000003796 107.0
TLS2_k127_4095209_15 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000002705 81.0
TLS2_k127_4095209_16 TIGRFAM formate dehydrogenase region TAT target - - - 0.0000000001271 64.0
TLS2_k127_4095209_2 PFAM amine oxidase K00274 - 1.4.3.4 2.344e-196 623.0
TLS2_k127_4095209_3 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 394.0
TLS2_k127_4095209_4 PFAM Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 366.0
TLS2_k127_4095209_5 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 336.0
TLS2_k127_4095209_6 WD domain, G-beta repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 302.0
TLS2_k127_4095209_7 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000001828 230.0
TLS2_k127_4095209_8 chaperone TorD - - - 0.00000000000000000000000000000000000000000000000000000000000000224 227.0
TLS2_k127_4095209_9 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000002356 188.0
TLS2_k127_4105348_0 COG2873 O-acetylhomoserine sulfhydrylase - - - 8.335e-215 674.0
TLS2_k127_4105348_1 Periplasmic glucan biosynthesis protein, MdoG K03670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 578.0
TLS2_k127_4105348_2 Malonyl-CoA decarboxylase N-terminal domain K01578 - 4.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 507.0
TLS2_k127_4105348_3 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 426.0
TLS2_k127_4105348_4 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 370.0
TLS2_k127_4105348_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006289 282.0
TLS2_k127_4105348_6 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000008939 178.0
TLS2_k127_4109649_0 COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 2.939e-233 737.0
TLS2_k127_4109649_1 Cobaltochelatase CobS subunit N terminal K09882 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 565.0
TLS2_k127_4109649_2 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.00000000000000000000000000000000000003598 154.0
TLS2_k127_4109649_3 DnaJ molecular chaperone homology domain - - - 0.000000000005953 66.0
TLS2_k127_411364_0 Hydantoinase/oxoprolinase N-terminal region - - - 5.878e-236 761.0
TLS2_k127_411364_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 348.0
TLS2_k127_411364_2 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000003159 246.0
TLS2_k127_411364_3 Gentisate 1,2-dioxygenase K00450 - 1.13.11.4 0.00000000000000000000000000000000000000000000000000000000000000002202 254.0
TLS2_k127_4121935_0 Belongs to the 5'-nucleotidase family K01081,K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 449.0
TLS2_k127_4121935_1 COG4618 ABC-type protease lipase transport system, ATPase and permease components K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004719 453.0
TLS2_k127_4121935_10 Protein of unknown function (DUF2390) - - - 0.000000000000000000000001023 114.0
TLS2_k127_4121935_11 Protein of unknown function (DUF465) - - - 0.000000000000000001499 89.0
TLS2_k127_4121935_12 Esterase-like activity of phytase - - - 0.00000000001291 73.0
TLS2_k127_4121935_13 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000001875 64.0
TLS2_k127_4121935_14 - - - - 0.00005287 50.0
TLS2_k127_4121935_2 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006975 426.0
TLS2_k127_4121935_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 347.0
TLS2_k127_4121935_4 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008362 282.0
TLS2_k127_4121935_5 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000005046 220.0
TLS2_k127_4121935_6 type I secretion membrane fusion protein, HlyD family K02022 - - 0.0000000000000000000000000000000000000000000000000000001907 211.0
TLS2_k127_4121935_7 Esterase-like activity of phytase - - - 0.0000000000000000000000000000000000000000000000000000004291 205.0
TLS2_k127_4121935_8 FR47-like protein K03829 - - 0.0000000000000000000000000000000000000000000000000002298 190.0
TLS2_k127_4121935_9 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000000000000001359 127.0
TLS2_k127_4123392_0 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051,K15576 - - 1.426e-247 771.0
TLS2_k127_4123392_1 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050,K15577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 443.0
TLS2_k127_4123392_2 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K15578 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 431.0
TLS2_k127_4123392_3 Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide K01725 - 4.2.1.104 0.0000000000000000000000000000000000000000000000000000000004706 207.0
TLS2_k127_4123392_4 AraC-binding-like domain - - - 0.000000000000000000000000000000000000000000000000126 189.0
TLS2_k127_4123392_5 uroporphyrin-III c-methyltransferase K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000001573 57.0
TLS2_k127_4133529_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000929 612.0
TLS2_k127_4133529_1 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009505 561.0
TLS2_k127_4133529_2 AsmA family K07289 - - 0.000000000000000000000000000000000000000000000000001342 202.0
TLS2_k127_4133529_3 - - - - 0.000000000000000000000000959 117.0
TLS2_k127_4135669_0 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 290.0
TLS2_k127_4135669_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008671 299.0
TLS2_k127_4135669_2 COG0694 Thioredoxin-like proteins and domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002273 278.0
TLS2_k127_4135669_3 Nitroreductase family K09019 - - 0.00000000000000000000000000000000000000000000000000000000000007689 229.0
TLS2_k127_4135669_4 FlgJ-related protein K03796 - - 0.0000000000000000000000000000000000000000000000006761 188.0
TLS2_k127_4135669_5 COG1214 Inactive homolog of metal-dependent proteases K14742 - - 0.0000000000000000000000000000000000000000000000275 178.0
TLS2_k127_4164720_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 594.0
TLS2_k127_4164720_1 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 372.0
TLS2_k127_4164720_3 Cytochrome c - - - 0.00000000000002598 78.0
TLS2_k127_417382_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01847 - 5.4.99.2 0.0 1089.0
TLS2_k127_417382_1 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 347.0
TLS2_k127_417382_2 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000001775 274.0
TLS2_k127_417382_3 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000002309 217.0
TLS2_k127_417382_4 Nudix hydrolase - - - 0.0000000000000000000000000000000000000000000000006907 183.0
TLS2_k127_417382_5 PFAM Cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000000000000133 174.0
TLS2_k127_417382_6 Fic/DOC family K07341 - - 0.00000000000000000000000000000001333 132.0
TLS2_k127_417382_7 Addiction module antidote - - - 0.0000000000000000001113 90.0
TLS2_k127_4232224_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 1.248e-228 713.0
TLS2_k127_4232224_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 565.0
TLS2_k127_4232224_10 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000657 279.0
TLS2_k127_4232224_11 PFAM Response regulator receiver domain K15012 GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005527 271.0
TLS2_k127_4232224_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002548 256.0
TLS2_k127_4232224_13 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.0000000000000000000000000000000000000000000000000000000009389 208.0
TLS2_k127_4232224_14 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000001066 187.0
TLS2_k127_4232224_15 protein conserved in bacteria K01876 - 6.1.1.12 0.00000000000000000000000000000000000000009992 158.0
TLS2_k127_4232224_16 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.000000000000000000000000000000000000004266 161.0
TLS2_k127_4232224_17 PFAM transglutaminase family protein cysteine peptidase BTLCP - - - 0.00000000000000000000000000000000000002486 156.0
TLS2_k127_4232224_18 Alpha/beta hydrolase family - - - 0.000000000000000000000000000001082 132.0
TLS2_k127_4232224_19 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000001164 134.0
TLS2_k127_4232224_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 568.0
TLS2_k127_4232224_20 - - - - 0.0000000000001882 84.0
TLS2_k127_4232224_21 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000007065 68.0
TLS2_k127_4232224_3 de-polymerase K05973 - 3.1.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 500.0
TLS2_k127_4232224_4 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 462.0
TLS2_k127_4232224_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 415.0
TLS2_k127_4232224_6 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 347.0
TLS2_k127_4232224_7 ATPases associated with a variety of cellular activities K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 332.0
TLS2_k127_4232224_8 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 331.0
TLS2_k127_4232224_9 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002746 280.0
TLS2_k127_4237057_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 2.608e-207 658.0
TLS2_k127_4237057_1 acetyl-coa acetyltransferase K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009198 565.0
TLS2_k127_4237057_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000005065 68.0
TLS2_k127_4290815_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 7.027e-232 728.0
TLS2_k127_4290815_1 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 6.097e-218 700.0
TLS2_k127_4290815_10 Amino-transferase class IV K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 331.0
TLS2_k127_4290815_11 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000002343 212.0
TLS2_k127_4290815_12 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000005484 224.0
TLS2_k127_4290815_13 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000000000000000000001784 202.0
TLS2_k127_4290815_14 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000005636 177.0
TLS2_k127_4290815_15 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000007315 182.0
TLS2_k127_4290815_16 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000437 142.0
TLS2_k127_4290815_17 PRC-barrel domain - - - 0.000000000000000000000000000000000007223 143.0
TLS2_k127_4290815_18 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000004329 134.0
TLS2_k127_4290815_19 CAAX protease self-immunity - - - 0.0000000000000000000004477 109.0
TLS2_k127_4290815_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 7.861e-196 621.0
TLS2_k127_4290815_20 Bacterial protein of unknown function (DUF883) - - - 0.0001414 51.0
TLS2_k127_4290815_21 AI-2E family transporter - - - 0.0001799 49.0
TLS2_k127_4290815_3 Potassium transporter peripheral membrane component K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 575.0
TLS2_k127_4290815_4 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005981 524.0
TLS2_k127_4290815_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 473.0
TLS2_k127_4290815_6 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009698 473.0
TLS2_k127_4290815_7 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 467.0
TLS2_k127_4290815_8 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 426.0
TLS2_k127_4290815_9 Short-chain alcohol dehydrogenase K16066 - 1.1.1.381 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 336.0
TLS2_k127_4314861_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1300.0
TLS2_k127_4314861_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.631e-283 886.0
TLS2_k127_4314861_10 Flavinator of succinate dehydrogenase K09159 - - 0.0000000000000000002486 92.0
TLS2_k127_4314861_11 Resolvase, N terminal domain - - - 0.000000061 58.0
TLS2_k127_4314861_2 Aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 9.913e-209 674.0
TLS2_k127_4314861_3 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 GO:0003674,GO:0003824,GO:0005488,GO:0006040,GO:0006044,GO:0006046,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008270,GO:0008448,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0016999,GO:0017001,GO:0017144,GO:0019213,GO:0019262,GO:0019752,GO:0022607,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 472.0
TLS2_k127_4314861_4 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005348 383.0
TLS2_k127_4314861_5 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 370.0
TLS2_k127_4314861_6 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 300.0
TLS2_k127_4314861_7 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006331 271.0
TLS2_k127_4314861_8 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000001877 239.0
TLS2_k127_4314861_9 Pentapeptide repeats (9 copies) - - - 0.00000000000000000000000000005997 129.0
TLS2_k127_4337817_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 482.0
TLS2_k127_4337817_1 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004352 253.0
TLS2_k127_4337817_2 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000000000000001491 194.0
TLS2_k127_4337817_3 Receptor family ligand binding region K01999 - - 0.00005575 51.0
TLS2_k127_4354951_0 ABC transporter transmembrane region K12541 - - 2.456e-254 813.0
TLS2_k127_4354951_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 1.397e-223 717.0
TLS2_k127_4354951_2 type I secretion membrane fusion protein, HlyD family K02022,K12542 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007722 287.0
TLS2_k127_4354951_3 Type I secretion membrane fusion protein, HlyD K02022,K12542 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002581 282.0
TLS2_k127_4354951_4 TIGRFAM type I secretion outer membrane protein, TolC family K12543 - - 0.000000000000000000000000000000000000000000000000000000000000000004108 247.0
TLS2_k127_4354951_5 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000001382 221.0
TLS2_k127_4354951_6 Hemimethylated DNA-binding protein YccV like K11940 - - 0.0000000000000000000000000000000000000000000000008578 177.0
TLS2_k127_4354951_7 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000004169 181.0
TLS2_k127_4354951_8 COG2931 RTX toxins and related Ca2 -binding proteins K01406,K07004 - 3.4.24.40 0.00006991 54.0
TLS2_k127_4379813_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1041.0
TLS2_k127_4379813_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.966e-288 896.0
TLS2_k127_4379813_10 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 543.0
TLS2_k127_4379813_11 Receptor family ligand binding region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008116 520.0
TLS2_k127_4379813_12 acyl-CoA transferases carnitine dehydratase K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 515.0
TLS2_k127_4379813_13 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 485.0
TLS2_k127_4379813_14 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006176 479.0
TLS2_k127_4379813_15 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007659 491.0
TLS2_k127_4379813_16 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009338 480.0
TLS2_k127_4379813_17 Cobalamin-independent synthase, Catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 473.0
TLS2_k127_4379813_18 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 456.0
TLS2_k127_4379813_19 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K03921,K20087 - 1.14.19.11,1.14.19.2,1.14.19.26,1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006913 445.0
TLS2_k127_4379813_2 Branched-chain amino acid ATP-binding cassette transporter - - - 5.146e-243 764.0
TLS2_k127_4379813_20 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 424.0
TLS2_k127_4379813_21 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 419.0
TLS2_k127_4379813_22 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 395.0
TLS2_k127_4379813_23 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008656 387.0
TLS2_k127_4379813_24 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 374.0
TLS2_k127_4379813_25 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 370.0
TLS2_k127_4379813_26 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008977 376.0
TLS2_k127_4379813_27 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008775 352.0
TLS2_k127_4379813_28 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 346.0
TLS2_k127_4379813_29 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 333.0
TLS2_k127_4379813_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.143e-238 745.0
TLS2_k127_4379813_30 PFAM 6-phosphogluconate dehydrogenase NAD-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 331.0
TLS2_k127_4379813_31 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 334.0
TLS2_k127_4379813_32 Belongs to the UPF0324 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 332.0
TLS2_k127_4379813_33 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 326.0
TLS2_k127_4379813_34 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003562 318.0
TLS2_k127_4379813_35 KR domain K00034 - 1.1.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 318.0
TLS2_k127_4379813_36 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 333.0
TLS2_k127_4379813_37 Diguanylate cyclase K21084 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 334.0
TLS2_k127_4379813_38 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005267 302.0
TLS2_k127_4379813_39 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 300.0
TLS2_k127_4379813_4 Periplasmic binding protein K01999 - - 1.745e-235 735.0
TLS2_k127_4379813_40 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009289 282.0
TLS2_k127_4379813_41 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002334 296.0
TLS2_k127_4379813_42 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009419 282.0
TLS2_k127_4379813_43 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003362 286.0
TLS2_k127_4379813_44 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K07052 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001588 285.0
TLS2_k127_4379813_45 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003458 268.0
TLS2_k127_4379813_46 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000315 263.0
TLS2_k127_4379813_47 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001436 262.0
TLS2_k127_4379813_48 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000002122 256.0
TLS2_k127_4379813_49 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000004007 241.0
TLS2_k127_4379813_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 7.353e-218 687.0
TLS2_k127_4379813_50 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000000000000000000000000000000000000004922 233.0
TLS2_k127_4379813_51 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000007118 231.0
TLS2_k127_4379813_52 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000001715 226.0
TLS2_k127_4379813_53 Response regulator receiver K11443 - - 0.00000000000000000000000000000000000000000000000000000000007432 208.0
TLS2_k127_4379813_54 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000001377 213.0
TLS2_k127_4379813_55 diguanylate cyclase K02488 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 0.00000000000000000000000000000000000000000000000000000001697 215.0
TLS2_k127_4379813_56 transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000002444 207.0
TLS2_k127_4379813_57 decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000001403 199.0
TLS2_k127_4379813_58 Esterase PHB depolymerase K03932 - - 0.0000000000000000000000000000000000000000000000000000009237 205.0
TLS2_k127_4379813_59 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000005663 193.0
TLS2_k127_4379813_6 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.446e-216 698.0
TLS2_k127_4379813_60 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000001768 183.0
TLS2_k127_4379813_61 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000000006424 184.0
TLS2_k127_4379813_62 DNA-binding transcription factor activity K03710 - - 0.000000000000000000000000000000000000000000001257 174.0
TLS2_k127_4379813_63 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000007299 175.0
TLS2_k127_4379813_64 Thioesterase superfamily - - - 0.000000000000000000000000000000000000003694 152.0
TLS2_k127_4379813_66 - - - - 0.0000000000000000000000000000000001371 138.0
TLS2_k127_4379813_67 Domain of unknown function (DUF1849) - - - 0.0000000000000000000000000000000003336 143.0
TLS2_k127_4379813_68 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000002482 128.0
TLS2_k127_4379813_69 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000004057 125.0
TLS2_k127_4379813_7 Uncharacterized protein conserved in bacteria (DUF2090) K03338 - 2.7.1.92 5.612e-206 669.0
TLS2_k127_4379813_70 Protein of unknown function (DUF3303) - - - 0.0000000000000000000000001703 116.0
TLS2_k127_4379813_71 PAS fold - - - 0.000000000000000002107 100.0
TLS2_k127_4379813_72 Ribosomal protein L33 K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000381 84.0
TLS2_k127_4379813_73 Acetyltransferase (GNAT) family - - - 0.00000000000001939 85.0
TLS2_k127_4379813_74 PAS domain - - - 0.0000000000009716 76.0
TLS2_k127_4379813_75 PAS domain - - - 0.00000006841 62.0
TLS2_k127_4379813_76 Domain of unknown function (DUF1849) - - - 0.00003429 57.0
TLS2_k127_4379813_8 symbiont process K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 604.0
TLS2_k127_4379813_9 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 557.0
TLS2_k127_4458560_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.0 1134.0
TLS2_k127_4458560_1 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005233 456.0
TLS2_k127_4458560_10 Sulphur oxidation protein SoxZ K17227 - - 0.00000000000000000000000000000000001199 146.0
TLS2_k127_4458560_11 serine threonine protein kinase - - - 0.000000002987 63.0
TLS2_k127_4458560_2 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 346.0
TLS2_k127_4458560_3 mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 293.0
TLS2_k127_4458560_4 Putative cyclase - GO:0003674,GO:0003824,GO:0005488,GO:0016787,GO:0016810,GO:0016812,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002426 265.0
TLS2_k127_4458560_5 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000004789 254.0
TLS2_k127_4458560_6 Cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000000000001748 196.0
TLS2_k127_4458560_7 Sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000000000000001562 170.0
TLS2_k127_4458560_8 DMSO reductase anchor subunit (DmsC) K18363 - - 0.0000000000000000000000000000000000000001239 162.0
TLS2_k127_4458560_9 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000000000000000000000509 152.0
TLS2_k127_4470798_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 474.0
TLS2_k127_4470798_1 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 440.0
TLS2_k127_4470798_10 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000009215 213.0
TLS2_k127_4470798_11 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000009131 192.0
TLS2_k127_4470798_12 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.000000000000000000000000000000000000000000000000001225 187.0
TLS2_k127_4470798_13 RNA signal recognition particle 4.5S RNA - - - 0.0000000000000000000000000000000000000000000378 171.0
TLS2_k127_4470798_14 helix-turn-helix- domain containing protein, AraC type - - - 0.00000000000000000000000000000000000000003313 175.0
TLS2_k127_4470798_15 ThiS family - - - 0.000000000000000000000002649 107.0
TLS2_k127_4470798_16 - - - - 0.00000001956 58.0
TLS2_k127_4470798_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 354.0
TLS2_k127_4470798_3 abc transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 332.0
TLS2_k127_4470798_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 316.0
TLS2_k127_4470798_5 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 305.0
TLS2_k127_4470798_6 PFAM binding-protein-dependent transport systems inner membrane component K02050,K15554 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006957 268.0
TLS2_k127_4470798_7 thiamine-containing compound biosynthetic process K02051,K15598 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008856 265.0
TLS2_k127_4470798_8 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000008361 225.0
TLS2_k127_4470798_9 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000009614 222.0
TLS2_k127_4536077_0 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 567.0
TLS2_k127_4536077_1 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 505.0
TLS2_k127_4536077_10 EthD domain - - - 0.0002688 48.0
TLS2_k127_4536077_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0009007 49.0
TLS2_k127_4536077_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 467.0
TLS2_k127_4536077_3 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 315.0
TLS2_k127_4536077_4 Protein of unknown function (DUF2848) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003552 270.0
TLS2_k127_4536077_5 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000003626 214.0
TLS2_k127_4536077_6 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000002274 178.0
TLS2_k127_4536077_7 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K16874 - - 0.000000000000000000000000000000000000709 156.0
TLS2_k127_4536077_8 MarR family transcriptional regulator - - - 0.000000000000000000000000000002703 127.0
TLS2_k127_4536077_9 MarR family - - - 0.00000000000000000000000002243 115.0
TLS2_k127_4539071_0 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs - - - 8.7e-322 1007.0
TLS2_k127_4539071_1 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000005901 248.0
TLS2_k127_4539071_2 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000002165 133.0
TLS2_k127_4539071_3 CHAT domain - - - 0.00000000000000000000001127 118.0
TLS2_k127_4616342_0 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009905 293.0
TLS2_k127_4616342_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000004317 237.0
TLS2_k127_4616342_2 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000001566 218.0
TLS2_k127_4631916_0 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 497.0
TLS2_k127_4631916_1 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 433.0
TLS2_k127_4631916_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 418.0
TLS2_k127_4631916_3 HNH endonuclease K07454 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 389.0
TLS2_k127_4631916_4 RES - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 310.0
TLS2_k127_4631916_5 - - - - 0.000000000000000000000000000000000000000000000000000000006165 209.0
TLS2_k127_4631916_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000007315 196.0
TLS2_k127_4631916_7 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000475 132.0
TLS2_k127_4631916_8 - - - - 0.000000000000000001031 94.0
TLS2_k127_466336_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008924 525.0
TLS2_k127_466336_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 492.0
TLS2_k127_466336_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 415.0
TLS2_k127_466336_3 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000000000004446 189.0
TLS2_k127_466336_4 Cupin - - - 0.0000000000000000000000000000000000000000000000003299 180.0
TLS2_k127_466336_5 Yqey-like protein K09117 - - 0.000000000000000000000000000000000003375 139.0
TLS2_k127_4677782_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 391.0
TLS2_k127_4677782_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 337.0
TLS2_k127_4677782_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000567 244.0
TLS2_k127_4677782_3 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000000006309 123.0
TLS2_k127_4713448_0 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009176 495.0
TLS2_k127_4713448_1 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 492.0
TLS2_k127_4713448_10 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 327.0
TLS2_k127_4713448_11 Aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 318.0
TLS2_k127_4713448_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K10617 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 303.0
TLS2_k127_4713448_13 Amidase K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001507 281.0
TLS2_k127_4713448_14 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000003572 264.0
TLS2_k127_4713448_15 Flavin-nucleotide-binding protein K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004008 246.0
TLS2_k127_4713448_16 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000129 231.0
TLS2_k127_4713448_17 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.000000000000000000000000000000000000000000000000000000000000003686 227.0
TLS2_k127_4713448_18 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000004881 216.0
TLS2_k127_4713448_19 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000003866 223.0
TLS2_k127_4713448_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 475.0
TLS2_k127_4713448_20 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000006136 212.0
TLS2_k127_4713448_21 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000005067 217.0
TLS2_k127_4713448_22 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000000000000000000000000127 200.0
TLS2_k127_4713448_23 OstA-like protein K09774 - - 0.000000000000000000000000000000000000000000000000000001374 201.0
TLS2_k127_4713448_24 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.000000000000000000000000000000000000000000000000000002788 196.0
TLS2_k127_4713448_25 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000004665 195.0
TLS2_k127_4713448_26 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.00000000000000000000000000000000000000000000000008129 183.0
TLS2_k127_4713448_27 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000004104 184.0
TLS2_k127_4713448_28 integral membrane protein - - - 0.000000000000000000000000000000000000000003716 162.0
TLS2_k127_4713448_29 Protein of unknown function (DUF1178) - - - 0.00000000000000000000000000000000000000008049 156.0
TLS2_k127_4713448_3 COG0524 Sugar kinases, ribokinase family K00847,K00856 - 2.7.1.20,2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 447.0
TLS2_k127_4713448_30 Protein of unknown function (DUF1761) - - - 0.000000000000000000000000000000000000001039 153.0
TLS2_k127_4713448_31 Etoposide-induced protein 2.4 (EI24) - - - 0.0000000000000000000000000000000000001418 151.0
TLS2_k127_4713448_32 - - - - 0.00000000000000000000000000000001913 136.0
TLS2_k127_4713448_33 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000001372 145.0
TLS2_k127_4713448_34 - - - - 0.000000000000000000000000000002243 126.0
TLS2_k127_4713448_36 - - - - 0.0000006007 57.0
TLS2_k127_4713448_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 434.0
TLS2_k127_4713448_5 aminotransferase class I and II K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 421.0
TLS2_k127_4713448_6 ABC transporter, ATP-binding protein K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 412.0
TLS2_k127_4713448_7 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 370.0
TLS2_k127_4713448_8 Sir2 family K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 333.0
TLS2_k127_4713448_9 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 319.0
TLS2_k127_4714834_0 Hydantoinase/oxoprolinase N-terminal region K01469 - 3.5.2.9 0.0 1726.0
TLS2_k127_4714834_1 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 582.0
TLS2_k127_4714834_10 Helix-turn-helix domain - - - 0.0000000000000000000000001314 114.0
TLS2_k127_4714834_11 Phage derived protein Gp49-like (DUF891) - - - 0.000000000000000000000027 101.0
TLS2_k127_4714834_12 ChaB K06197 - - 0.000000000000000002792 87.0
TLS2_k127_4714834_13 Phage derived protein Gp49-like (DUF891) - - - 0.0000002889 53.0
TLS2_k127_4714834_2 transport system fused permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 559.0
TLS2_k127_4714834_3 Cobalamin-independent synthase, Catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 521.0
TLS2_k127_4714834_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 372.0
TLS2_k127_4714834_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 353.0
TLS2_k127_4714834_6 TIGRFAM TRAP transporter solute receptor, TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009373 310.0
TLS2_k127_4714834_7 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001651 228.0
TLS2_k127_4714834_8 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000002104 203.0
TLS2_k127_4714834_9 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000004531 166.0
TLS2_k127_472972_0 Bacterial extracellular solute-binding protein K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 391.0
TLS2_k127_472972_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 386.0
TLS2_k127_472972_2 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008729 316.0
TLS2_k127_472972_3 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002542 276.0
TLS2_k127_472972_4 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001317 272.0
TLS2_k127_472972_5 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000000007563 240.0
TLS2_k127_472972_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000001364 227.0
TLS2_k127_472972_7 PFAM binding-protein-dependent transport systems inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000000006919 200.0
TLS2_k127_473012_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 588.0
TLS2_k127_473012_1 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 412.0
TLS2_k127_473012_2 PFAM O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002538 272.0
TLS2_k127_473012_3 OpgC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000296 268.0
TLS2_k127_473012_4 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K02395 - - 0.00000000000000000000000000000000000000001064 164.0
TLS2_k127_473012_5 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000001026 132.0
TLS2_k127_473012_6 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000002781 127.0
TLS2_k127_473012_7 nuclease - - - 0.00000000000000000000000002006 122.0
TLS2_k127_473012_8 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000009914 110.0
TLS2_k127_473012_9 Methyltransferase domain - - - 0.0000003169 59.0
TLS2_k127_4784573_0 Adenylate - - - 2.311e-259 837.0
TLS2_k127_4784573_1 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 1.011e-258 803.0
TLS2_k127_4784573_2 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 447.0
TLS2_k127_4784573_3 Prokaryotic cytochrome b561 K00127 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 436.0
TLS2_k127_4784573_4 4Fe-4S dicluster domain K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 415.0
TLS2_k127_4784573_5 Molybdopterin guanine dinucleotide synthesis protein B K03753 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000001464 236.0
TLS2_k127_4784573_6 COG0314 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000001924 209.0
TLS2_k127_4784573_7 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000000001311 111.0
TLS2_k127_4789623_0 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 3.354e-248 794.0
TLS2_k127_4789623_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 559.0
TLS2_k127_4789623_2 YceG-like family K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 318.0
TLS2_k127_4789623_3 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 295.0
TLS2_k127_4789623_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009805 302.0
TLS2_k127_4789623_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006197 278.0
TLS2_k127_4789623_6 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000001235 263.0
TLS2_k127_4798797_0 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009501 557.0
TLS2_k127_4798797_1 Belongs to the ABC transporter superfamily K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 553.0
TLS2_k127_4798797_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 483.0
TLS2_k127_4798797_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 429.0
TLS2_k127_4798797_4 Enoyl-(Acyl carrier protein) reductase K00019,K18335 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 314.0
TLS2_k127_4798797_5 KR domain K21883 - 1.1.1.401 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 324.0
TLS2_k127_4798797_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K08319 - 1.1.1.411 0.000000000000000000000000000000000000000000000000000000000000000000001303 248.0
TLS2_k127_4798797_7 Regulatory protein GntR HTH - - - 0.0000000000000000000000000000000000000000000000000000000001067 213.0
TLS2_k127_4800931_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1277.0
TLS2_k127_4800931_1 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009925 396.0
TLS2_k127_4800931_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 330.0
TLS2_k127_4804189_0 COG2873 O-acetylhomoserine sulfhydrylase K01738,K01740 - 2.5.1.47,2.5.1.49 4.847e-201 634.0
TLS2_k127_4804189_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009737 587.0
TLS2_k127_4804189_10 - - - - 0.0000000000000000000000000000000000000000000003864 176.0
TLS2_k127_4804189_11 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000005287 169.0
TLS2_k127_4804189_12 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000000000002582 125.0
TLS2_k127_4804189_13 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000005083 122.0
TLS2_k127_4804189_14 - - - - 0.00000000000000000000000002172 111.0
TLS2_k127_4804189_15 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000002933 106.0
TLS2_k127_4804189_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 540.0
TLS2_k127_4804189_3 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 352.0
TLS2_k127_4804189_4 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 317.0
TLS2_k127_4804189_5 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 303.0
TLS2_k127_4804189_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000001815 230.0
TLS2_k127_4804189_7 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000004092 228.0
TLS2_k127_4804189_8 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000000008068 242.0
TLS2_k127_4804189_9 glyoxalase bleomycin resistance protein dioxygenase K20431 - 5.1.3.33 0.00000000000000000000000000000000000000000000000001614 185.0
TLS2_k127_4810355_0 DNA polymerase K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1163.0
TLS2_k127_4810355_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1131.0
TLS2_k127_4810355_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007935 271.0
TLS2_k127_4810355_11 COG0346 Lactoylglutathione lyase and related lyases K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000001682 245.0
TLS2_k127_4810355_12 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001907 261.0
TLS2_k127_4810355_13 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000009752 207.0
TLS2_k127_4810355_14 Protein of unknown function (DUF1467) - - - 0.000000000000003949 80.0
TLS2_k127_4810355_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 2.736e-213 671.0
TLS2_k127_4810355_3 NADH ubiquinone oxidoreductase subunit 4 (chain M) K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 3.881e-209 659.0
TLS2_k127_4810355_4 hydrolase of the metallo-beta-lactamase superfamily K12574 - - 1.772e-195 640.0
TLS2_k127_4810355_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 589.0
TLS2_k127_4810355_6 Permease family K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 510.0
TLS2_k127_4810355_7 COG4591 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 396.0
TLS2_k127_4810355_8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 330.0
TLS2_k127_4810355_9 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000214 275.0
TLS2_k127_4811993_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 3.093e-295 932.0
TLS2_k127_4811993_1 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 424.0
TLS2_k127_4811993_2 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 392.0
TLS2_k127_4811993_3 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 319.0
TLS2_k127_4811993_4 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001887 285.0
TLS2_k127_4811993_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000009985 250.0
TLS2_k127_4811993_6 glutathione s-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000002242 237.0
TLS2_k127_4811993_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000001777 227.0
TLS2_k127_4811993_8 - - - - 0.00000000000000000000000000000000002221 147.0
TLS2_k127_4838244_0 ABC-type multidrug transport system, ATPase and permease K06147,K11085 - - 2.431e-199 639.0
TLS2_k127_4838244_1 Zn-dependent proteases and their inactivated homologs K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005669 556.0
TLS2_k127_4838244_10 3-deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000006285 267.0
TLS2_k127_4838244_11 Tyrosine phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001866 263.0
TLS2_k127_4838244_12 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003825 271.0
TLS2_k127_4838244_13 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006345 269.0
TLS2_k127_4838244_14 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000004123 235.0
TLS2_k127_4838244_15 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000000000000000000000000000000000001751 222.0
TLS2_k127_4838244_16 protein possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000000000000000000004498 192.0
TLS2_k127_4838244_17 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000372 149.0
TLS2_k127_4838244_18 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000389 168.0
TLS2_k127_4838244_19 MarR family - - - 0.00000000000000000000000000000168 128.0
TLS2_k127_4838244_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 522.0
TLS2_k127_4838244_20 Dual-action HEIGH metallo-peptidase - - - 0.0000000000000000000000000001534 124.0
TLS2_k127_4838244_21 Regulator of ribonuclease activity B - - - 0.0002646 50.0
TLS2_k127_4838244_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 433.0
TLS2_k127_4838244_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 404.0
TLS2_k127_4838244_5 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 363.0
TLS2_k127_4838244_6 COG0744 Membrane carboxypeptidase (penicillin-binding protein) K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 335.0
TLS2_k127_4838244_7 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 326.0
TLS2_k127_4838244_8 Sugar (and other) transporter K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 321.0
TLS2_k127_4838244_9 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008688 299.0
TLS2_k127_4861179_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.943e-221 698.0
TLS2_k127_4861179_1 Domain of unknown function (DUF3492) K21011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008758 527.0
TLS2_k127_4861179_10 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002043 243.0
TLS2_k127_4861179_11 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000005598 252.0
TLS2_k127_4861179_12 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000001044 204.0
TLS2_k127_4861179_13 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000475 185.0
TLS2_k127_4861179_14 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000006796 167.0
TLS2_k127_4861179_15 peptidyl-tyrosine sulfation K21010 - - 0.000000000000000000000000000000000001573 152.0
TLS2_k127_4861179_16 Bacteriophage N adsorption protein A C-term - - - 0.000000877 63.0
TLS2_k127_4861179_2 PFAM TM1410 hypothetical-related protein K21006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 556.0
TLS2_k127_4861179_3 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003777 458.0
TLS2_k127_4861179_4 Putative exopolysaccharide Exporter (EPS-E) K21012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 421.0
TLS2_k127_4861179_5 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 336.0
TLS2_k127_4861179_6 DNA polymerase III subunit delta K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002366 290.0
TLS2_k127_4861179_7 Glycoside-hydrolase family GH114 K21006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005023 278.0
TLS2_k127_4861179_8 Gaf domain K02584,K07713,K11908,K12266,K15836,K21009,K21405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005631 308.0
TLS2_k127_4861179_9 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000002604 246.0
TLS2_k127_49196_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 9.617e-255 799.0
TLS2_k127_49196_1 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 439.0
TLS2_k127_49196_10 - - - - 0.0000000000000000007006 96.0
TLS2_k127_49196_12 - K02221 - - 0.000000000000005292 79.0
TLS2_k127_49196_13 Protein of unknown function (DUF1353) - - - 0.000000000002366 74.0
TLS2_k127_49196_14 L,D-transpeptidase catalytic domain - - - 0.0000000003071 61.0
TLS2_k127_49196_2 Metal-binding integral membrane protein - - - 0.0000000000000000000000000000000000000000000000000000001349 209.0
TLS2_k127_49196_3 Haemolysin-type calcium binding protein related domain K01406 - 3.4.24.40 0.000000000000000000000000000000000000000000000000004954 204.0
TLS2_k127_49196_4 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000000008276 167.0
TLS2_k127_49196_5 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000004171 171.0
TLS2_k127_49196_6 GIY-YIG catalytic domain - - - 0.0000000000000000000000000000003992 126.0
TLS2_k127_49196_7 - - - - 0.00000000000000000000000000007805 124.0
TLS2_k127_49196_8 membrane - - - 0.0000000000000000000000000006686 118.0
TLS2_k127_49196_9 MafB19-like deaminase - - - 0.0000000000000000000000000221 114.0
TLS2_k127_4921366_0 Ring hydroxylating alpha subunit (catalytic domain) K00479,K16319 - 1.14.12.1 1.672e-211 663.0
TLS2_k127_4921366_1 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 617.0
TLS2_k127_4921366_10 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009052 372.0
TLS2_k127_4921366_11 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 387.0
TLS2_k127_4921366_12 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 370.0
TLS2_k127_4921366_13 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004983 377.0
TLS2_k127_4921366_14 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005743 377.0
TLS2_k127_4921366_15 Steryl acetyl hydrolase K14731 - 3.1.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 323.0
TLS2_k127_4921366_16 KR domain K00059,K07535 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 299.0
TLS2_k127_4921366_17 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000007326 239.0
TLS2_k127_4921366_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000002535 220.0
TLS2_k127_4921366_19 Ring hydroxylating beta subunit - - - 0.000000000000000000000000000000000000000000000000000000119 210.0
TLS2_k127_4921366_2 PFAM Prokaryotic protein of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 572.0
TLS2_k127_4921366_20 carbohydrate transport K11688 - - 0.000000000000000000000000000000000000000000000000000003196 203.0
TLS2_k127_4921366_21 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000001222 167.0
TLS2_k127_4921366_22 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000004251 131.0
TLS2_k127_4921366_23 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000009695 119.0
TLS2_k127_4921366_24 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000001358 87.0
TLS2_k127_4921366_25 MmgE PrpD family protein - - - 0.0000000000000003621 87.0
TLS2_k127_4921366_26 lactoylglutathione lyase activity - - - 0.000008306 57.0
TLS2_k127_4921366_3 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 578.0
TLS2_k127_4921366_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 574.0
TLS2_k127_4921366_5 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912,K14747 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 543.0
TLS2_k127_4921366_6 AMP-binding enzyme C-terminal domain K02363 - 2.7.7.58,6.3.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 481.0
TLS2_k127_4921366_7 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 471.0
TLS2_k127_4921366_8 C4-dicarboxylate ABC transporter permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 464.0
TLS2_k127_4921366_9 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 392.0
TLS2_k127_4925735_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 2.151e-260 820.0
TLS2_k127_4925735_1 C-terminal region of peptidase_M24 K01262 - 3.4.11.9 2.231e-203 649.0
TLS2_k127_4925735_10 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 384.0
TLS2_k127_4925735_11 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 379.0
TLS2_k127_4925735_12 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009247 360.0
TLS2_k127_4925735_13 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 363.0
TLS2_k127_4925735_14 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 347.0
TLS2_k127_4925735_15 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 335.0
TLS2_k127_4925735_16 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 302.0
TLS2_k127_4925735_17 ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000742 243.0
TLS2_k127_4925735_18 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008044 229.0
TLS2_k127_4925735_19 Dioxygenase K00449 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000005607 205.0
TLS2_k127_4925735_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 8.318e-198 645.0
TLS2_k127_4925735_20 Cell division protein FtsQ K03589 - - 0.0000000000000000000000000000000000000002206 171.0
TLS2_k127_4925735_21 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000005736 152.0
TLS2_k127_4925735_3 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 574.0
TLS2_k127_4925735_4 DNA helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 519.0
TLS2_k127_4925735_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 511.0
TLS2_k127_4925735_6 PFAM General secretory system II protein E domain protein K11740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 488.0
TLS2_k127_4925735_7 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 442.0
TLS2_k127_4925735_8 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 437.0
TLS2_k127_4925735_9 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 418.0
TLS2_k127_4937853_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K19745 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006436 280.0
TLS2_k127_4937853_1 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000233 266.0
TLS2_k127_4937853_2 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008114 260.0
TLS2_k127_4937853_3 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000002759 226.0
TLS2_k127_4946283_0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 548.0
TLS2_k127_4946283_1 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 522.0
TLS2_k127_4946283_10 transcription elongation factor GreA GreB K06140 - - 0.000000000000000000000000008468 117.0
TLS2_k127_4946283_11 Protein of unknown function (DUF1491) - - - 0.00000000000000000000000008977 111.0
TLS2_k127_4946283_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 457.0
TLS2_k127_4946283_3 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16171 - 3.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 431.0
TLS2_k127_4946283_4 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001535 276.0
TLS2_k127_4946283_5 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000005346 184.0
TLS2_k127_4946283_6 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000001218 159.0
TLS2_k127_4946283_7 protein conserved in bacteria - - - 0.0000000000000000000000000000000000006849 146.0
TLS2_k127_4946283_8 Extensin-like protein C-terminus - - - 0.000000000000000000000000000000001684 142.0
TLS2_k127_4946283_9 - - - - 0.0000000000000000000000000003061 126.0
TLS2_k127_4953390_0 ABC1 family - - - 2.406e-196 621.0
TLS2_k127_4953390_1 oligoendopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 492.0
TLS2_k127_4953390_2 Periplasmic sensor domain found in signal transduction proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 409.0
TLS2_k127_4953390_3 Alanine dehydrogenase/PNT, C-terminal domain K00324 GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000002232 278.0
TLS2_k127_4953390_4 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.000000000000000000000000000000000000000000000001124 177.0
TLS2_k127_4953390_5 PRC-barrel domain - - - 0.00000003554 64.0
TLS2_k127_4954479_0 COG1960 Acyl-CoA dehydrogenases K14448 - 1.3.8.12 5.333e-264 822.0
TLS2_k127_4954479_1 rieske 2fe-2s - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 393.0
TLS2_k127_4954479_2 PIN domain - - - 0.00000000000000000000000000000003097 130.0
TLS2_k127_4954479_3 - - - - 0.000000000000001099 81.0
TLS2_k127_4955161_0 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 1.032e-220 695.0
TLS2_k127_4955161_1 TIGRFAM ATP-dependent DNA helicase, RecQ K03654 - 3.6.4.12 1.281e-197 645.0
TLS2_k127_4955161_10 Pfam Amidohydrolase K07045 - - 0.000000000000000000000000000000000009532 152.0
TLS2_k127_4955161_11 Transcriptional regulator - - - 0.00000000000000000000000000000000005322 145.0
TLS2_k127_4955161_12 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000001377 130.0
TLS2_k127_4955161_13 Dehydratase - - - 0.00000000000000000000000000000151 133.0
TLS2_k127_4955161_14 Trap-type c4-dicarboxylate transport system, small permease component - - - 0.00000000000000000000000000009021 124.0
TLS2_k127_4955161_15 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000000001069 110.0
TLS2_k127_4955161_16 - - - - 0.00000000000000004602 90.0
TLS2_k127_4955161_2 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000719 549.0
TLS2_k127_4955161_3 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009812 440.0
TLS2_k127_4955161_4 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 425.0
TLS2_k127_4955161_5 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 313.0
TLS2_k127_4955161_6 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006162 295.0
TLS2_k127_4955161_7 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000136 267.0
TLS2_k127_4955161_8 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000000000000001598 172.0
TLS2_k127_4955161_9 Transcriptional regulator - - - 0.000000000000000000000000000000000000001466 169.0
TLS2_k127_4978045_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.572e-292 910.0
TLS2_k127_4978045_1 Alcohol dehydrogenase GroES-like domain K00121 - 1.1.1.1,1.1.1.284 6.035e-207 655.0
TLS2_k127_4978045_10 flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009145 339.0
TLS2_k127_4978045_11 MotA TolQ ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 319.0
TLS2_k127_4978045_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 308.0
TLS2_k127_4978045_13 (ABC) transporter K05685,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 302.0
TLS2_k127_4978045_14 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 305.0
TLS2_k127_4978045_15 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000003579 276.0
TLS2_k127_4978045_16 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004028 258.0
TLS2_k127_4978045_17 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005605 268.0
TLS2_k127_4978045_18 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000006996 229.0
TLS2_k127_4978045_19 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000001059 237.0
TLS2_k127_4978045_2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 523.0
TLS2_k127_4978045_20 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000001683 212.0
TLS2_k127_4978045_21 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000004099 179.0
TLS2_k127_4978045_22 Belongs to the acetyltransferase family. ArgA subfamily K03828 - - 0.00000000000000000000000000000000000000000000003244 174.0
TLS2_k127_4978045_23 - - - - 0.00000000000000000000000000000000000000000000005045 171.0
TLS2_k127_4978045_24 - - - - 0.0000000000000000000000000000000000000000000001946 172.0
TLS2_k127_4978045_25 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000004819 173.0
TLS2_k127_4978045_26 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000005271 171.0
TLS2_k127_4978045_27 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000008935 162.0
TLS2_k127_4978045_28 - - - - 0.00000000000000000000000000000000001681 143.0
TLS2_k127_4978045_29 Cold shock K03704 - - 0.0000000000000000000000000004501 117.0
TLS2_k127_4978045_3 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 480.0
TLS2_k127_4978045_30 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000001884 124.0
TLS2_k127_4978045_31 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000000000001203 109.0
TLS2_k127_4978045_32 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000002893 91.0
TLS2_k127_4978045_33 - - - - 0.00000000000001449 79.0
TLS2_k127_4978045_4 Lipoprotein releasing system transmembrane protein LolC K09808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0098796,GO:0098797 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 481.0
TLS2_k127_4978045_5 lysyl-tRNA synthetase K04568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 430.0
TLS2_k127_4978045_6 TIGRFAM lysine 2,3-aminomutase YodO family protein K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 424.0
TLS2_k127_4978045_7 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007216 368.0
TLS2_k127_4978045_8 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 346.0
TLS2_k127_4978045_9 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 347.0
TLS2_k127_5002916_0 CHASE2 K01768 - 4.6.1.1 3.647e-211 679.0
TLS2_k127_5002916_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 466.0
TLS2_k127_5002916_2 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 423.0
TLS2_k127_5002916_3 Pfam:DUF4102 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 327.0
TLS2_k127_5002916_4 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008322 262.0
TLS2_k127_5002916_5 Sugar (and other) transporter K07552 - - 0.0000000000000000000000000000000000000000000000000000000000000000001415 245.0
TLS2_k127_5002916_6 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000008814 144.0
TLS2_k127_5002916_7 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000001295 127.0
TLS2_k127_5002916_8 PAS domain - - - 0.0000000000000000000002637 103.0
TLS2_k127_5002916_9 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000003164 98.0
TLS2_k127_5039296_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 450.0
TLS2_k127_5039296_1 ROK family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006809 387.0
TLS2_k127_5039296_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000001542 235.0
TLS2_k127_5039296_3 Domain of unknown function (DUF1849) - - - 0.0000000000000000000000000000000000000000000000000000001008 211.0
TLS2_k127_5039296_4 CBS domain - - - 0.0000000000000000000000000000000000000000000002374 175.0
TLS2_k127_5039296_5 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21563 - - 0.0000000000000000000000000000000000000000002885 175.0
TLS2_k127_5039296_6 - - - - 0.000000000000000000000000000000000000000001098 164.0
TLS2_k127_5039296_7 Protein of unknown function (DUF992) - - - 0.000000000000000000000000000000000002799 145.0
TLS2_k127_5039296_8 - - - - 0.00000000002024 72.0
TLS2_k127_5039296_9 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00004755 54.0
TLS2_k127_5048155_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.495e-274 862.0
TLS2_k127_5048155_1 FAD binding domain K00104,K05797 - 1.1.3.15,1.17.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 566.0
TLS2_k127_5048155_10 transport system small permease component - - - 0.00000000000000000000000000000000000000000000000000002898 195.0
TLS2_k127_5048155_11 Domain of unknown function (DUF1772) - - - 0.000000000000000000000000000000000000000000006593 179.0
TLS2_k127_5048155_12 Thioredoxin K03671 - - 0.000000000000000000000000000000000000009116 147.0
TLS2_k127_5048155_13 protein conserved in bacteria K09975 - - 0.000000000000000000000000000000000005277 145.0
TLS2_k127_5048155_14 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000000004163 103.0
TLS2_k127_5048155_16 - - - - 0.00000000004145 74.0
TLS2_k127_5048155_2 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 556.0
TLS2_k127_5048155_3 Belongs to the KdsA family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006783 448.0
TLS2_k127_5048155_4 extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 447.0
TLS2_k127_5048155_5 Belongs to the D-glutamate cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 365.0
TLS2_k127_5048155_6 peptidylprolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 313.0
TLS2_k127_5048155_7 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000003454 267.0
TLS2_k127_5048155_8 protein-L-isoaspartate O-methyltransferase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000001294 269.0
TLS2_k127_5048155_9 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease - - - 0.00000000000000000000000000000000000000000000000000000000001353 212.0
TLS2_k127_5052211_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1703.0
TLS2_k127_5052211_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 476.0
TLS2_k127_5052211_10 Flp pilus assembly protein, pilin Flp K02651 - - 0.00000000496 60.0
TLS2_k127_5052211_11 EamA-like transporter family - - - 0.00003382 55.0
TLS2_k127_5052211_2 GH3 auxin-responsive promoter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000942 450.0
TLS2_k127_5052211_3 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 417.0
TLS2_k127_5052211_4 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 394.0
TLS2_k127_5052211_5 Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 327.0
TLS2_k127_5052211_6 Precorrin-8x methylmutase - - - 0.0000000000000000000000000000000000000000000000000000000000003474 223.0
TLS2_k127_5052211_7 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000001537 213.0
TLS2_k127_5052211_8 Domain of Unknown Function (DUF350) K08989 - - 0.000000000000000000000005208 111.0
TLS2_k127_5052211_9 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.000000000000006327 82.0
TLS2_k127_510632_0 This protein is involved in the repair of mismatches in DNA K03555 - - 3.05e-318 991.0
TLS2_k127_510632_1 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 351.0
TLS2_k127_510632_2 signal transduction histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 350.0
TLS2_k127_510632_3 serine threonine protein kinase K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005794 299.0
TLS2_k127_510632_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000001448 212.0
TLS2_k127_510632_5 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000007436 216.0
TLS2_k127_510632_6 - - - - 0.000000004366 68.0
TLS2_k127_510632_7 - - - - 0.0004578 51.0
TLS2_k127_5178831_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1079.0
TLS2_k127_5178831_1 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 339.0
TLS2_k127_5178831_2 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000985 318.0
TLS2_k127_5178831_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 313.0
TLS2_k127_5178831_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 321.0
TLS2_k127_5178831_5 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000001493 199.0
TLS2_k127_5178831_6 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000003863 192.0
TLS2_k127_5182102_0 COG1960 Acyl-CoA dehydrogenases K20035 - - 2.088e-220 698.0
TLS2_k127_5182102_1 PFAM Cytochrome bd ubiquinol oxidase, subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 571.0
TLS2_k127_5182102_10 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000000000000000000000000000000000009043 167.0
TLS2_k127_5182102_11 Protein conserved in bacteria K01153 - 3.1.21.3 0.000000000000000000000005553 106.0
TLS2_k127_5182102_2 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 529.0
TLS2_k127_5182102_3 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 452.0
TLS2_k127_5182102_4 TIGRFAM cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 385.0
TLS2_k127_5182102_5 PFAM luciferase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 386.0
TLS2_k127_5182102_6 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 353.0
TLS2_k127_5182102_7 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001105 288.0
TLS2_k127_5182102_8 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000005756 213.0
TLS2_k127_5182102_9 - - - - 0.0000000000000000000000000000000000000000000000000000000001175 209.0
TLS2_k127_5198932_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1211.0
TLS2_k127_5198932_1 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 513.0
TLS2_k127_5198932_10 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000001274 209.0
TLS2_k127_5198932_11 Pfam:DUF461 K09796 - - 0.0000000000000000000000000000007919 138.0
TLS2_k127_5198932_2 cobalamin synthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 425.0
TLS2_k127_5198932_3 Protein of unknown function (DUF2817) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 406.0
TLS2_k127_5198932_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 381.0
TLS2_k127_5198932_5 Protein of unknown function (DUF2817) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009756 391.0
TLS2_k127_5198932_6 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006347 296.0
TLS2_k127_5198932_7 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000002679 249.0
TLS2_k127_5198932_8 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000564 234.0
TLS2_k127_5198932_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000102 224.0
TLS2_k127_5236459_0 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 4.129e-266 829.0
TLS2_k127_5236459_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 406.0
TLS2_k127_5236459_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 332.0
TLS2_k127_5236459_3 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009023 298.0
TLS2_k127_5236459_4 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000003748 267.0
TLS2_k127_5236459_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000009442 227.0
TLS2_k127_5236459_6 Protein of unknown function (DUF2927) - - - 0.0000000000000000000002038 106.0
TLS2_k127_5236459_7 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000002566 80.0
TLS2_k127_5246860_0 AcrB/AcrD/AcrF family K03296,K07788,K07789,K21133 - - 0.0 1168.0
TLS2_k127_5246860_1 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 449.0
TLS2_k127_5246860_2 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 405.0
TLS2_k127_5246860_3 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 393.0
TLS2_k127_5246860_4 of ABC transporters with duplicated ATPase K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 384.0
TLS2_k127_5246860_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004439 317.0
TLS2_k127_5312385_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 2.613e-271 848.0
TLS2_k127_5312385_1 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 1.201e-203 644.0
TLS2_k127_5312385_10 Protein of unknown function (DUF983) - - - 0.000000000000000000000000000000000000000000003303 171.0
TLS2_k127_5312385_11 COG1393 Arsenate reductase and related proteins, glutaredoxin family K00537 - 1.20.4.1 0.0000000000000000000000000000000001883 135.0
TLS2_k127_5312385_12 Methyltransferase domain - - - 0.00000000000000000000000008441 126.0
TLS2_k127_5312385_13 MarR family - - - 0.0000000000000000000000001657 115.0
TLS2_k127_5312385_14 KR domain K21883 - 1.1.1.401 0.000000000000001897 76.0
TLS2_k127_5312385_15 Threonine synthase K01733 - 4.2.3.1 0.0000000000001675 72.0
TLS2_k127_5312385_16 - - - - 0.0000000003141 66.0
TLS2_k127_5312385_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009612 418.0
TLS2_k127_5312385_3 cytochrome c oxidase K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 379.0
TLS2_k127_5312385_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 341.0
TLS2_k127_5312385_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001954 265.0
TLS2_k127_5312385_6 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002175 268.0
TLS2_k127_5312385_7 CorA-like Mg2+ transporter protein K16074 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000000000000000000000000000000000000000001155 233.0
TLS2_k127_5312385_8 SURF1-like protein K14998 - - 0.0000000000000000000000000000000000000000000000000000000000004289 220.0
TLS2_k127_5312385_9 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.0000000000000000000000000000000000000000000000000000001667 201.0
TLS2_k127_5321982_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1360.0
TLS2_k127_5321982_1 Alpha-2-Macroglobulin K06894 - - 0.0 1236.0
TLS2_k127_5321982_10 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000003791 148.0
TLS2_k127_5321982_11 - - - - 0.000001945 55.0
TLS2_k127_5321982_12 Peptidase M16 inactive domain K07263 - - 0.0003551 50.0
TLS2_k127_5321982_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 3.232e-268 856.0
TLS2_k127_5321982_3 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 615.0
TLS2_k127_5321982_4 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007011 514.0
TLS2_k127_5321982_5 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 368.0
TLS2_k127_5321982_6 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 329.0
TLS2_k127_5321982_7 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 317.0
TLS2_k127_5321982_8 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000000000000000000001256 214.0
TLS2_k127_5321982_9 COG2030 Acyl dehydratase K17865 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016043,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0042620,GO:0042621,GO:0043933,GO:0044085,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576 4.2.1.55 0.000000000000000000000000000000000000000000000000000003364 196.0
TLS2_k127_5351979_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1238.0
TLS2_k127_5351979_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006063 516.0
TLS2_k127_5351979_2 3-beta hydroxysteroid dehydrogenase/isomerase family K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 419.0
TLS2_k127_5351979_3 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004947 254.0
TLS2_k127_5351979_4 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000002282 216.0
TLS2_k127_5351979_5 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000734 214.0
TLS2_k127_5351979_6 Protein of unknown function (DUF1344) - - - 0.00001225 51.0
TLS2_k127_5420206_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 504.0
TLS2_k127_5420206_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 352.0
TLS2_k127_5420206_2 PFAM monooxygenase FAD-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 336.0
TLS2_k127_5420206_3 N-formylglutamate amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001302 280.0
TLS2_k127_5420206_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001177 265.0
TLS2_k127_5420206_5 Protein of unknown function (DUF1244) K09948 - - 0.000000000000000000000000000000000000000001287 164.0
TLS2_k127_5420206_6 Uncharacterized protein conserved in bacteria (DUF2312) - - - 0.00000000000000000000007129 104.0
TLS2_k127_5420206_7 PFAM Cold-shock protein, DNA-binding - - - 0.00000000000000000001623 107.0
TLS2_k127_5420206_8 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000001709 61.0
TLS2_k127_5420206_9 Phenylacetate-CoA oxygenase K02609 - 1.14.13.149 0.00000003294 55.0
TLS2_k127_542088_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 377.0
TLS2_k127_542088_1 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002282 246.0
TLS2_k127_5544426_0 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 353.0
TLS2_k127_5544426_1 Binding-protein-dependent transport system inner membrane component K02042 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 327.0
TLS2_k127_5544426_2 Binding-protein-dependent transport system inner membrane component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 325.0
TLS2_k127_5544426_3 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000008442 178.0
TLS2_k127_5544426_4 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000001698 171.0
TLS2_k127_5544426_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000001151 150.0
TLS2_k127_5544426_6 Aha1 domain protein - - - 0.00000000000000000000000000000000003516 142.0
TLS2_k127_5544426_7 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.0000000000000000000000000007224 119.0
TLS2_k127_5544426_8 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000007842 69.0
TLS2_k127_5565011_0 Belongs to the peptidase S16 family - - - 1.308e-266 846.0
TLS2_k127_5565011_1 Heat shock 70 kDa protein K04043 - - 2.618e-263 822.0
TLS2_k127_5565011_10 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 310.0
TLS2_k127_5565011_11 Histidine kinase K20975 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009329 295.0
TLS2_k127_5565011_12 SpoU rRNA Methylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001866 249.0
TLS2_k127_5565011_13 Rieske [2Fe-2S] domain K18068 - 1.14.12.7 0.00000000000000000000000000000000000000000000000000000000000000000001048 247.0
TLS2_k127_5565011_14 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000002391 224.0
TLS2_k127_5565011_15 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000007785 178.0
TLS2_k127_5565011_16 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000005098 178.0
TLS2_k127_5565011_17 BON domain - - - 0.00000000000000000000000000000000000000000003051 167.0
TLS2_k127_5565011_18 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000001252 171.0
TLS2_k127_5565011_19 Papain-like cysteine protease AvrRpt2 - - - 0.00000000000000000000000000000000000001773 153.0
TLS2_k127_5565011_2 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 544.0
TLS2_k127_5565011_20 Zincin-like metallopeptidase - - - 0.00000000000000000000000000000000000004231 149.0
TLS2_k127_5565011_21 Transcriptional regulator, Crp Fnr family K01420,K15861 - - 0.00000000000000000000000000000000509 137.0
TLS2_k127_5565011_22 4-alpha-hydroxytetrahydrobiopterin dehydratase activity K01724 GO:0000003,GO:0003006,GO:0003674,GO:0003712,GO:0003713,GO:0003824,GO:0004497,GO:0004505,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0007049,GO:0008124,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009653,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019219,GO:0019222,GO:0019439,GO:0019752,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030435,GO:0030437,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0031981,GO:0032502,GO:0032505,GO:0034293,GO:0042737,GO:0042763,GO:0042764,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043436,GO:0043496,GO:0043933,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045893,GO:0045935,GO:0046395,GO:0048468,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051098,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0051321,GO:0051704,GO:0055114,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0140110,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222,GO:1902680,GO:1903046,GO:1903506,GO:1903508,GO:2000112,GO:2001141 4.2.1.96 0.0000000000000000000000000000001749 138.0
TLS2_k127_5565011_23 Endoribonuclease L-PSP - - - 0.0000000000000000002233 102.0
TLS2_k127_5565011_24 TfoX N-terminal domain - - - 0.00000000000000001089 91.0
TLS2_k127_5565011_25 Transcriptional regulator - - - 0.00000000000008104 78.0
TLS2_k127_5565011_26 invasion associated locus B - - - 0.0000008224 59.0
TLS2_k127_5565011_27 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00013 51.0
TLS2_k127_5565011_28 Histidine kinase - - - 0.0009772 47.0
TLS2_k127_5565011_3 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 483.0
TLS2_k127_5565011_4 Domain of unknown function DUF87 K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 489.0
TLS2_k127_5565011_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 445.0
TLS2_k127_5565011_6 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 394.0
TLS2_k127_5565011_7 Domain of unknown function (DUF1848) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 349.0
TLS2_k127_5565011_8 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 342.0
TLS2_k127_5565011_9 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 340.0
TLS2_k127_5601778_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 1.65e-208 660.0
TLS2_k127_5601778_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 546.0
TLS2_k127_5601778_10 Domain of unknown function (DUF4143) - - - 0.000000000000000000000001125 119.0
TLS2_k127_5601778_13 2'-5' RNA ligase superfamily - - - 0.000009482 57.0
TLS2_k127_5601778_2 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 499.0
TLS2_k127_5601778_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008265 492.0
TLS2_k127_5601778_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 491.0
TLS2_k127_5601778_5 serine threonine protein kinase K08282 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000008688 288.0
TLS2_k127_5601778_6 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000005828 223.0
TLS2_k127_5601778_7 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000004269 208.0
TLS2_k127_5601778_8 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000002008 168.0
TLS2_k127_5601778_9 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000001234 149.0
TLS2_k127_5613955_0 NAD-specific glutamate dehydrogenase K15371 - 1.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 457.0
TLS2_k127_5613955_1 Thioredoxin K05838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 328.0
TLS2_k127_5613955_2 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000000000000000000000000000000000000009795 210.0
TLS2_k127_5613955_3 to the N-terminal domain of Lon protease K01338,K07157 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000003993 204.0
TLS2_k127_5613955_4 Carboxylesterase family K01432 - 3.5.1.9 0.00000000000000000000000000000001137 146.0
TLS2_k127_5613955_5 Trm112p-like protein K09791 - - 0.00000000000000000002201 93.0
TLS2_k127_5613955_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000002526 63.0
TLS2_k127_5614057_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 8.513e-260 808.0
TLS2_k127_5614057_1 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 421.0
TLS2_k127_5614057_2 glycolate oxidase iron-sulfur subunit K11473 - - 0.00000000000000000000000000000000000000000000000000000007174 196.0
TLS2_k127_5623525_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 6.388e-263 833.0
TLS2_k127_5623525_1 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 1.96e-232 745.0
TLS2_k127_5623525_10 TonB-dependent receptor K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 489.0
TLS2_k127_5623525_11 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 454.0
TLS2_k127_5623525_12 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 474.0
TLS2_k127_5623525_13 3-beta hydroxysteroid dehydrogenase/isomerase family K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 450.0
TLS2_k127_5623525_14 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008163 434.0
TLS2_k127_5623525_15 copper-resistance protein, CopA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 441.0
TLS2_k127_5623525_16 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 421.0
TLS2_k127_5623525_17 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 412.0
TLS2_k127_5623525_18 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 412.0
TLS2_k127_5623525_19 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 425.0
TLS2_k127_5623525_2 Psort location Cytoplasmic, score 7.50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 610.0
TLS2_k127_5623525_20 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 394.0
TLS2_k127_5623525_21 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 384.0
TLS2_k127_5623525_22 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 348.0
TLS2_k127_5623525_23 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 352.0
TLS2_k127_5623525_24 Squalene/phytoene synthase K21678,K21679 - 2.5.1.103,4.2.3.156 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 319.0
TLS2_k127_5623525_25 Amino Acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 321.0
TLS2_k127_5623525_26 Phytoene synthase K21678 - 2.5.1.103 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 301.0
TLS2_k127_5623525_27 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 299.0
TLS2_k127_5623525_28 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003865 286.0
TLS2_k127_5623525_29 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007351 286.0
TLS2_k127_5623525_3 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 608.0
TLS2_k127_5623525_30 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006282 254.0
TLS2_k127_5623525_31 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000001046 251.0
TLS2_k127_5623525_32 ATP-binding protein K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000002721 265.0
TLS2_k127_5623525_33 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000001982 241.0
TLS2_k127_5623525_34 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000756 221.0
TLS2_k127_5623525_35 Peptidase S9 prolyl oligopeptidase active site K01281 - 3.4.14.11 0.0000000000000000000000000000000000000000000000000000001265 210.0
TLS2_k127_5623525_36 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000007858 213.0
TLS2_k127_5623525_37 - - - - 0.000000000000000000000000000000000000000000000000342 188.0
TLS2_k127_5623525_38 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000000000154 176.0
TLS2_k127_5623525_39 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000002869 177.0
TLS2_k127_5623525_4 Domain of unknown function (DUF3463) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 571.0
TLS2_k127_5623525_40 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000007861 171.0
TLS2_k127_5623525_41 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000004365 150.0
TLS2_k127_5623525_42 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000001075 142.0
TLS2_k127_5623525_43 Protein of unknown function (DUF2442) - - - 0.00000000000000000000000000000000001526 141.0
TLS2_k127_5623525_44 COG1530 Ribonucleases G and E K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000164 151.0
TLS2_k127_5623525_45 - - - - 0.0000000000000000000000000000000426 138.0
TLS2_k127_5623525_46 Protein of unknown function (DUF4031) - - - 0.0000000000000000000000000000001285 125.0
TLS2_k127_5623525_47 MlaC protein K07323 - - 0.0000000000000000000000000000005166 130.0
TLS2_k127_5623525_48 Phosphorylase superfamily K01243 - 3.2.2.9 0.000000000000000000000009593 111.0
TLS2_k127_5623525_49 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000005648 79.0
TLS2_k127_5623525_5 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 553.0
TLS2_k127_5623525_6 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 510.0
TLS2_k127_5623525_7 COG3970 Fumarylacetoacetate (FAA) hydrolase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 488.0
TLS2_k127_5623525_8 MMPL family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 509.0
TLS2_k127_5623525_9 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008532 482.0
TLS2_k127_5664936_0 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 462.0
TLS2_k127_5664936_1 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 319.0
TLS2_k127_5664936_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 312.0
TLS2_k127_5664936_3 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001881 274.0
TLS2_k127_5664936_4 - - - - 0.000000000000000000000000000008787 126.0
TLS2_k127_5664936_5 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K14446 - 1.3.1.85 0.000000000000000001336 85.0
TLS2_k127_5664936_6 - - - - 0.0000000004555 64.0
TLS2_k127_5664936_8 - - - - 0.00004051 55.0
TLS2_k127_5665889_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 580.0
TLS2_k127_5665889_1 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 379.0
TLS2_k127_5665889_2 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 342.0
TLS2_k127_5665889_3 ornithine cyclodeaminase mu-crystallin K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000005912 185.0
TLS2_k127_5665889_4 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000008928 95.0
TLS2_k127_5685191_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 8.514e-217 679.0
TLS2_k127_5685191_1 Participates in both transcription termination and antitermination K02600 - - 4.505e-213 676.0
TLS2_k127_5685191_10 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003773 279.0
TLS2_k127_5685191_11 transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001681 277.0
TLS2_k127_5685191_12 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000006508 263.0
TLS2_k127_5685191_13 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000001845 209.0
TLS2_k127_5685191_14 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000000001431 179.0
TLS2_k127_5685191_15 ROS/MUCR transcriptional regulator protein - - - 0.00000000000000000000000000000000000000000000007933 174.0
TLS2_k127_5685191_16 transcriptional - - - 0.0000000000000000000000000000000000000000000001888 175.0
TLS2_k127_5685191_17 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000009385 147.0
TLS2_k127_5685191_18 TPR repeat - - - 0.0000000000000000000000000003955 124.0
TLS2_k127_5685191_19 Ring hydroxylating subunit beta family protein 1 - - - 0.00000000000000000000000001422 126.0
TLS2_k127_5685191_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009422 597.0
TLS2_k127_5685191_20 Trap-type c4-dicarboxylate transport system, small permease component K11689 - - 0.0000000000000000000000002681 122.0
TLS2_k127_5685191_21 Protein of unknown function (DUF448) K07742 - - 0.00000000000000008707 82.0
TLS2_k127_5685191_22 Transcriptional regulator, GntR family - - - 0.000000000000002973 86.0
TLS2_k127_5685191_23 acetyltransferase K01409,K03789,K14742 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128,2.3.1.234 0.000000002533 60.0
TLS2_k127_5685191_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 491.0
TLS2_k127_5685191_4 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008819 437.0
TLS2_k127_5685191_5 COG1702 Phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 390.0
TLS2_k127_5685191_6 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 358.0
TLS2_k127_5685191_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 343.0
TLS2_k127_5685191_8 COG1253 Hemolysins and related proteins containing CBS domains K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 304.0
TLS2_k127_5685191_9 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000962 279.0
TLS2_k127_5685790_0 COG0513 Superfamily II DNA and RNA helicases K17675 - 3.6.4.13 1.973e-268 851.0
TLS2_k127_5685790_1 Domain of unknown function (DUF4339) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 460.0
TLS2_k127_5685790_10 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004343 267.0
TLS2_k127_5685790_11 Protein of unknown function (DUF1223) - - - 0.00000000000000000000000000000000000000000000000002086 190.0
TLS2_k127_5685790_12 PFAM 5-bromo-4-chloroindolyl phosphate hydrolysis protein - - - 0.000000000000000000000000000000000000000000654 168.0
TLS2_k127_5685790_13 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000001247 129.0
TLS2_k127_5685790_14 light absorption - - - 0.00000000000000000000000000000214 125.0
TLS2_k127_5685790_15 recycling of the 50S subunit K04762 - - 0.0000000000000000000000824 115.0
TLS2_k127_5685790_16 membrane protein, hemolysin III homolog K11068 - - 0.000000000000000000001513 96.0
TLS2_k127_5685790_17 transmembrane transport K03442 - - 0.000000000000000000002824 104.0
TLS2_k127_5685790_18 Zinc-finger domain - - - 0.000000000000000004033 86.0
TLS2_k127_5685790_2 Belongs to the TelA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 429.0
TLS2_k127_5685790_20 Ca2 -binding protein (EF-Hand superfamily - - - 0.000003718 57.0
TLS2_k127_5685790_21 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000003939 56.0
TLS2_k127_5685790_3 COG1131 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 425.0
TLS2_k127_5685790_4 COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 382.0
TLS2_k127_5685790_5 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 360.0
TLS2_k127_5685790_6 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 337.0
TLS2_k127_5685790_7 COG2267 Lysophospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 318.0
TLS2_k127_5685790_8 Integral membrane protein TerC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 301.0
TLS2_k127_5685790_9 COG2267 Lysophospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001103 283.0
TLS2_k127_5698098_0 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 562.0
TLS2_k127_5698098_1 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 506.0
TLS2_k127_5698098_2 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000414 249.0
TLS2_k127_5698098_3 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000001477 244.0
TLS2_k127_5698098_4 Thioredoxin-like K08344 - - 0.00000000000000000000000000000000000000000002022 174.0
TLS2_k127_5698098_5 - - - - 0.000000001569 66.0
TLS2_k127_5715757_0 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family K00354,K10680 - 1.6.99.1 1.642e-210 664.0
TLS2_k127_5715757_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000001862 140.0
TLS2_k127_5715757_2 transcriptional regulator - - - 0.00000000000000000000000007843 114.0
TLS2_k127_5715757_3 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000008019 68.0
TLS2_k127_5716377_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.214e-281 876.0
TLS2_k127_5716377_1 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 352.0
TLS2_k127_5716377_10 - - - - 0.000000000000000000000000000000000000000001346 171.0
TLS2_k127_5716377_11 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000002743 160.0
TLS2_k127_5716377_12 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.0000000000000000000000000000000000000001054 153.0
TLS2_k127_5716377_13 Hsp20/alpha crystallin family K13993 - - 0.000000000000000000000000000000004857 135.0
TLS2_k127_5716377_14 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000003858 93.0
TLS2_k127_5716377_2 translation release factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 349.0
TLS2_k127_5716377_3 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 294.0
TLS2_k127_5716377_4 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 284.0
TLS2_k127_5716377_5 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000008441 260.0
TLS2_k127_5716377_6 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002635 271.0
TLS2_k127_5716377_7 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000003627 240.0
TLS2_k127_5716377_8 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000000000000000000000000000000495 211.0
TLS2_k127_5716377_9 racemase activity, acting on amino acids and derivatives - - - 0.000000000000000000000000000000000000000000000136 191.0
TLS2_k127_5717340_0 carboxylase K01969 - 6.4.1.4 8.092e-260 809.0
TLS2_k127_5717340_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000001642 140.0
TLS2_k127_5770912_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.987e-283 887.0
TLS2_k127_5770912_1 Sodium/hydrogen exchanger family K03316 - - 7.458e-236 760.0
TLS2_k127_5770912_10 PFAM Substrate-binding region of ABC-type glycine betaine transport system K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 421.0
TLS2_k127_5770912_11 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000888 423.0
TLS2_k127_5770912_12 ATP-grasp domain K09181 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 415.0
TLS2_k127_5770912_13 Dehydrogenase E1 component K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 372.0
TLS2_k127_5770912_14 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 379.0
TLS2_k127_5770912_15 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 349.0
TLS2_k127_5770912_16 N-formylglutamate amidohydrolase K01458,K01479 - 3.5.1.68,3.5.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 321.0
TLS2_k127_5770912_17 COG1226 Kef-type K transport systems K10716 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 319.0
TLS2_k127_5770912_18 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007393 302.0
TLS2_k127_5770912_19 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000002175 184.0
TLS2_k127_5770912_2 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 5.158e-212 677.0
TLS2_k127_5770912_20 COG1607 Acyl-CoA hydrolase K10806 - - 0.00000000000000000000000000000000000000000000000002034 183.0
TLS2_k127_5770912_21 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000001284 174.0
TLS2_k127_5770912_22 nuclear chromosome segregation - - - 0.000000000000000000000000000000000001026 147.0
TLS2_k127_5770912_23 Universal stress protein family - - - 0.0000000000000000000000000000000006478 142.0
TLS2_k127_5770912_24 PIN domain K07065 - - 0.00000000000000000000000000384 115.0
TLS2_k127_5770912_25 Asp/Glu/Hydantoin racemase - - - 0.000000000000000000000000017 122.0
TLS2_k127_5770912_26 SOS response K14160 - - 0.00000000000000000000000005908 123.0
TLS2_k127_5770912_27 - - - - 0.000000000000000000000004299 104.0
TLS2_k127_5770912_28 - - - - 0.00000000001982 75.0
TLS2_k127_5770912_29 Domain of unknown function (DUF1127) - - - 0.0000000005909 65.0
TLS2_k127_5770912_3 Sodium/hydrogen exchanger family K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005743 616.0
TLS2_k127_5770912_30 - K21495 - - 0.000000001757 61.0
TLS2_k127_5770912_4 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 536.0
TLS2_k127_5770912_5 Amidohydrolase family K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 519.0
TLS2_k127_5770912_6 imidazolonepropionase activity K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007235 514.0
TLS2_k127_5770912_7 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 521.0
TLS2_k127_5770912_8 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 446.0
TLS2_k127_5770912_9 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049,K15555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 421.0
TLS2_k127_5822548_0 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004606 362.0
TLS2_k127_5822548_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004041 270.0
TLS2_k127_5822548_2 protein histidine kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007194 285.0
TLS2_k127_5822548_3 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000171 256.0
TLS2_k127_5822548_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000008072 241.0
TLS2_k127_5822548_5 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006841 262.0
TLS2_k127_5822548_6 photoreceptor activity - - - 0.000000004217 71.0
TLS2_k127_5822548_7 sequence-specific DNA binding - - - 0.000001016 57.0
TLS2_k127_5831398_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 446.0
TLS2_k127_5831398_1 transport systems, ATPase components K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 405.0
TLS2_k127_5831398_10 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.0000000000000000000000684 108.0
TLS2_k127_5831398_11 Protein of unknown function (DUF1826) - - - 0.0000000000000000002254 98.0
TLS2_k127_5831398_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 306.0
TLS2_k127_5831398_3 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 314.0
TLS2_k127_5831398_4 COG4531 ABC-type Zn2 transport system, periplasmic component surface adhesin K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003771 275.0
TLS2_k127_5831398_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000001716 225.0
TLS2_k127_5831398_6 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000000000000000000000000000000000009339 179.0
TLS2_k127_5831398_7 transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000001883 166.0
TLS2_k127_5831398_8 - - - - 0.0000000000000000000000000000000000000319 151.0
TLS2_k127_5831398_9 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000267 121.0
TLS2_k127_5841647_0 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 479.0
TLS2_k127_5841647_1 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 461.0
TLS2_k127_5841647_2 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 456.0
TLS2_k127_5841647_3 MOSC N-terminal beta barrel domain K07140 - - 0.00000000000000000000000000000000000000000000004995 181.0
TLS2_k127_5841647_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000001138 110.0
TLS2_k127_5841647_5 Domain of unknown function (DUF4167) - - - 0.00000000000000000008695 101.0
TLS2_k127_5856336_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 613.0
TLS2_k127_5856336_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 409.0
TLS2_k127_58611_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 5.696e-252 793.0
TLS2_k127_58611_1 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008307 599.0
TLS2_k127_58611_2 DegT/DnrJ/EryC1/StrS aminotransferase family K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 462.0
TLS2_k127_58611_3 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000000000000000000000000000000000000000000000000000000000000000299 236.0
TLS2_k127_58611_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000000000000000000000000000004497 199.0
TLS2_k127_58611_5 COG0303 Molybdopterin biosynthesis enzyme K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000001017 196.0
TLS2_k127_58611_6 Cytotoxic translational repressor of toxin-antitoxin stability system - - - 0.00007865 48.0
TLS2_k127_5861210_0 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 532.0
TLS2_k127_5861210_1 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 345.0
TLS2_k127_5861210_2 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.000000000000000000000000000000000000000000000000000000000006164 216.0
TLS2_k127_5861210_3 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.0000000000000000000000000000000000000000000000000000000919 199.0
TLS2_k127_5861210_4 HupE / UreJ protein K03192 - - 0.00000000000000000000000000000000000000000166 167.0
TLS2_k127_5861210_5 Protein of unknown function (DUF3995) - - - 0.0000000000000000000000002335 118.0
TLS2_k127_5882461_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 4.472e-196 621.0
TLS2_k127_5882461_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000002374 218.0
TLS2_k127_5882461_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000000000000000000000008921 209.0
TLS2_k127_5882461_3 PFAM PilT protein domain protein - - - 0.0000000000000000000000000000000000000000000000000001034 188.0
TLS2_k127_5882461_4 Bacterial antitoxin of type II TA system, VapB - - - 0.00000000000000000000002374 104.0
TLS2_k127_5882461_5 translation initiation inhibitor, yjgF family - - - 0.00000000000000000004149 92.0
TLS2_k127_5882461_6 SpoVT / AbrB like domain - - - 0.000000000000000003409 90.0
TLS2_k127_588837_0 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 495.0
TLS2_k127_588837_1 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000004764 248.0
TLS2_k127_588837_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase K00455 - 1.13.11.15 0.00000000000000000000000000000000000000000000000001965 190.0
TLS2_k127_588837_3 marr family - - - 0.00000000000000006133 87.0
TLS2_k127_5907250_0 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 464.0
TLS2_k127_5907250_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000532 386.0
TLS2_k127_5907250_2 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 372.0
TLS2_k127_5907250_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 331.0
TLS2_k127_5907250_4 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001456 281.0
TLS2_k127_5907250_5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000001118 254.0
TLS2_k127_5907250_6 Protein of unknown function, DUF488 - - - 0.000000000004667 70.0
TLS2_k127_5911291_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 542.0
TLS2_k127_5911291_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 355.0
TLS2_k127_5911291_2 Pterin binding enzyme K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000003637 267.0
TLS2_k127_5911291_3 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000002263 254.0
TLS2_k127_5911291_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000182 64.0
TLS2_k127_5917674_0 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 314.0
TLS2_k127_5917674_1 dihydroorotate dehydrogenase activity K02823,K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000001149 187.0
TLS2_k127_5917674_2 MmgE/PrpD family - - - 0.0000000000000000000000000000000002617 146.0
TLS2_k127_5917674_3 hydroxyacid-oxoacid transhydrogenase activity K00001,K19954 - 1.1.1.1 0.00000000000000000000000000000001329 147.0
TLS2_k127_5921148_0 nitrate reductase beta subunit K00371,K17051 - 1.7.5.1 2.206e-294 907.0
TLS2_k127_5921148_1 Respiratory nitrate reductase alpha N-terminal K00370 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 394.0
TLS2_k127_5921148_2 nitrate reductase, gamma subunit K00374 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 317.0
TLS2_k127_5921148_3 protein involved in response to NO K07234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008203 280.0
TLS2_k127_5921148_4 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000007334 268.0
TLS2_k127_5921148_5 Glycosyltransferase family 87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003854 241.0
TLS2_k127_5921148_6 Nitrate reductase, delta subunit K00373 - - 0.0000000000000000000000000000000000000000000000000002137 192.0
TLS2_k127_5921148_7 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000003674 116.0
TLS2_k127_5939724_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 1.433e-266 831.0
TLS2_k127_5939724_1 PFAM AMP-dependent synthetase and ligase K18661 - - 1.393e-238 747.0
TLS2_k127_5939724_2 LysR substrate binding domain K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 325.0
TLS2_k127_5939724_3 Domain of unknown function (DUF1127) - - - 0.000000001674 62.0
TLS2_k127_5956029_0 COG0165 Argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 6.381e-203 642.0
TLS2_k127_5956029_1 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009989 599.0
TLS2_k127_5956029_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004873 487.0
TLS2_k127_5956029_3 Domain of unknown function (DUF4175) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 352.0
TLS2_k127_5956029_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 341.0
TLS2_k127_5956029_5 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000001147 161.0
TLS2_k127_5956029_6 Auxin binding protein - - - 0.000000000000001762 81.0
TLS2_k127_5958347_0 dioxygenase K11159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 583.0
TLS2_k127_5958347_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 406.0
TLS2_k127_5958347_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 352.0
TLS2_k127_5958347_3 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000994 344.0
TLS2_k127_5958347_4 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006945 348.0
TLS2_k127_5958347_5 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 288.0
TLS2_k127_5958347_6 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007499 237.0
TLS2_k127_5958347_7 Carboxylesterase family K01066 - - 0.000000000000000000000000000000000000000000000000000000000006443 222.0
TLS2_k127_5958347_8 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000003064 198.0
TLS2_k127_5958347_9 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000005653 137.0
TLS2_k127_5967132_0 PFAM short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 321.0
TLS2_k127_5967132_1 PFAM binding-protein-dependent transport systems inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000002707 241.0
TLS2_k127_5967132_2 PFAM binding-protein-dependent transport systems inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000002255 231.0
TLS2_k127_5967132_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000537 227.0
TLS2_k127_5982356_0 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 438.0
TLS2_k127_5982356_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 434.0
TLS2_k127_5982356_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009472 426.0
TLS2_k127_5982356_3 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001486 260.0
TLS2_k127_5982356_4 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07226 - - 0.00000000000000000000000000000000000000000000000000000001693 205.0
TLS2_k127_5982356_5 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000007248 100.0
TLS2_k127_5982356_6 Belongs to the universal stress protein A family - - - 0.0000000000001519 77.0
TLS2_k127_5982356_7 MobA-like NTP transferase domain - - - 0.00000000000496 74.0
TLS2_k127_5991947_0 Type II/IV secretion system protein K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004186 552.0
TLS2_k127_5991947_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 423.0
TLS2_k127_5991947_10 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000003777 251.0
TLS2_k127_5991947_11 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000001398 224.0
TLS2_k127_5991947_12 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000001409 184.0
TLS2_k127_5991947_13 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000004314 105.0
TLS2_k127_5991947_2 Dihydrodipicolinate synthetase family K01714 GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 398.0
TLS2_k127_5991947_3 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 375.0
TLS2_k127_5991947_4 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008485 354.0
TLS2_k127_5991947_5 AAA domain K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 346.0
TLS2_k127_5991947_6 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 347.0
TLS2_k127_5991947_7 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 316.0
TLS2_k127_5991947_8 cytochrome p450 K21033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004582 271.0
TLS2_k127_5991947_9 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000005484 249.0
TLS2_k127_5992185_0 Ribonuclease E/G family K08300 - 3.1.26.12 3.009e-206 668.0
TLS2_k127_5992185_1 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 309.0
TLS2_k127_5992185_2 - - - - 0.00001643 49.0
TLS2_k127_6001628_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.029e-292 905.0
TLS2_k127_6001628_1 NADH:flavin oxidoreductase / NADH oxidase family K09461 - 1.14.13.40 7.158e-292 915.0
TLS2_k127_6001628_10 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 414.0
TLS2_k127_6001628_11 PFAM AMP-dependent synthetase and ligase K04110 - 6.2.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 408.0
TLS2_k127_6001628_12 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 390.0
TLS2_k127_6001628_13 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 381.0
TLS2_k127_6001628_14 dehalogenase K21647 - 1.21.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 379.0
TLS2_k127_6001628_15 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 364.0
TLS2_k127_6001628_16 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 354.0
TLS2_k127_6001628_17 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 351.0
TLS2_k127_6001628_18 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009845 351.0
TLS2_k127_6001628_19 Methylenetetrahydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 335.0
TLS2_k127_6001628_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 3.725e-277 860.0
TLS2_k127_6001628_20 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 334.0
TLS2_k127_6001628_21 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 324.0
TLS2_k127_6001628_22 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 320.0
TLS2_k127_6001628_23 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 312.0
TLS2_k127_6001628_24 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 300.0
TLS2_k127_6001628_25 enoyl-CoA hydratase K20036 - 4.2.1.155 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 293.0
TLS2_k127_6001628_26 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000579 290.0
TLS2_k127_6001628_27 KR domain - - - 0.00000000000000000000000000000000000000000000000000000001978 206.0
TLS2_k127_6001628_28 PFAM major facilitator superfamily MFS_1 K08177 - - 0.0000000000000000000000000000000000000000000000000000001182 210.0
TLS2_k127_6001628_29 - - - - 0.000000000000000000000000000000000000000000000000000001809 205.0
TLS2_k127_6001628_3 PFAM AMP-dependent synthetase and ligase K12508 - 6.2.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 571.0
TLS2_k127_6001628_30 Arac family - - - 0.000000000000000000000000000000000000000000000000000005375 202.0
TLS2_k127_6001628_31 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000008144 180.0
TLS2_k127_6001628_32 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000009222 182.0
TLS2_k127_6001628_33 GYD domain - - - 0.000000000000000000000000000000000005949 143.0
TLS2_k127_6001628_34 PFAM Peptidase M15A - - - 0.00000000000000000000000000000000001052 141.0
TLS2_k127_6001628_35 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000001099 132.0
TLS2_k127_6001628_36 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000005786 120.0
TLS2_k127_6001628_37 Acyl dehydratase - - - 0.0000000000000000000000002427 110.0
TLS2_k127_6001628_38 - - - - 0.00000000002232 71.0
TLS2_k127_6001628_39 Neurotransmitter Na symporter K03308 - - 0.00000002622 60.0
TLS2_k127_6001628_4 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 499.0
TLS2_k127_6001628_40 binding domain protein - - - 0.00000009712 63.0
TLS2_k127_6001628_41 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00002938 53.0
TLS2_k127_6001628_5 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 487.0
TLS2_k127_6001628_6 AMP-binding enzyme C-terminal domain K04116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004513 466.0
TLS2_k127_6001628_7 CoA-transferase family III K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 456.0
TLS2_k127_6001628_8 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 437.0
TLS2_k127_6001628_9 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 423.0
TLS2_k127_6062824_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 3.164e-202 635.0
TLS2_k127_6062824_1 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 - 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 431.0
TLS2_k127_6062824_2 Cytochrome C1 family K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000004102 243.0
TLS2_k127_6062824_3 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000000000000000000000000000000000003764 249.0
TLS2_k127_6062824_4 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000001144 192.0
TLS2_k127_6062824_5 CBS domain - - - 0.00000000000000000000000000000000000000000006077 169.0
TLS2_k127_6062824_6 - - - - 0.00000000000000000000000000000000000000871 153.0
TLS2_k127_6062824_7 - - - - 0.000000000000001089 78.0
TLS2_k127_6078993_0 aminopeptidase N K01256 - 3.4.11.2 0.0 1187.0
TLS2_k127_6078993_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 2.791e-234 736.0
TLS2_k127_6078993_10 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000009436 207.0
TLS2_k127_6078993_11 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000005373 193.0
TLS2_k127_6078993_12 - - - - 0.00000000000000000000004028 104.0
TLS2_k127_6078993_13 Phasin protein - - - 0.00000000000000000000253 102.0
TLS2_k127_6078993_14 - - - - 0.00000000000000000003756 101.0
TLS2_k127_6078993_15 BFD-like [2Fe-2S] binding domain K02192 - - 0.0000000004006 64.0
TLS2_k127_6078993_16 Small protein - - - 0.000000003643 66.0
TLS2_k127_6078993_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 476.0
TLS2_k127_6078993_3 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00651 - 2.3.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 385.0
TLS2_k127_6078993_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 376.0
TLS2_k127_6078993_5 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 290.0
TLS2_k127_6078993_6 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 287.0
TLS2_k127_6078993_7 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000002348 252.0
TLS2_k127_6078993_8 transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000004595 239.0
TLS2_k127_6078993_9 Iron-storage protein K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000001114 217.0
TLS2_k127_6080391_0 transport system fused permease components - - - 2.127e-213 683.0
TLS2_k127_6080391_1 transport system periplasmic component K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 445.0
TLS2_k127_6080391_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 314.0
TLS2_k127_6080391_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 321.0
TLS2_k127_6080391_4 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000000000000001561 208.0
TLS2_k127_6080391_5 GIY-YIG catalytic domain K07461 - - 0.0000000000000000000000000157 111.0
TLS2_k127_6080391_6 Thioesterase superfamily K01075 - 3.1.2.23 0.00000000000000000000007398 104.0
TLS2_k127_609268_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0 1081.0
TLS2_k127_609268_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.635e-205 651.0
TLS2_k127_609268_10 Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5- (5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 322.0
TLS2_k127_609268_11 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 297.0
TLS2_k127_609268_12 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000169 275.0
TLS2_k127_609268_13 membrane-bound lytic murein transglycosylase K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007599 273.0
TLS2_k127_609268_14 Putative transmembrane protein (Alph_Pro_TM) - - - 0.00000000000000000000000000000000000000000000000000000000000000003085 239.0
TLS2_k127_609268_15 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000003163 229.0
TLS2_k127_609268_16 import inner membrane translocase, subunit Tim44 - - - 0.0000000000000000000000000000000000000000000000000003872 192.0
TLS2_k127_609268_17 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000000000000000000000000000007113 174.0
TLS2_k127_609268_18 LUD domain K00782 - - 0.00000000000000000000000000000000000000000000001385 194.0
TLS2_k127_609268_19 universal stress protein UspA and related nucleotide-binding - - - 0.00000000000000000000000000000000000000000000001935 177.0
TLS2_k127_609268_2 LUD domain K18929 - - 2.029e-195 627.0
TLS2_k127_609268_20 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.00000000000000000000000000000000000000000169 162.0
TLS2_k127_609268_21 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.0000000000000000000000000000000000001059 147.0
TLS2_k127_609268_22 protein conserved in bacteria - - - 0.00000000000000000000000000001121 128.0
TLS2_k127_609268_23 Dodecin K09165 - - 0.0000000000000000000000003117 107.0
TLS2_k127_609268_24 Protein of unknown function (DUF2283) - - - 0.0000000000002477 76.0
TLS2_k127_609268_25 - - - - 0.0000000000004387 79.0
TLS2_k127_609268_26 Protein of unknown function (DUF2628) - - - 0.00000000014 73.0
TLS2_k127_609268_27 Glycosyl transferase family 2 - - - 0.000000001066 68.0
TLS2_k127_609268_28 - - - - 0.0004549 51.0
TLS2_k127_609268_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009665 472.0
TLS2_k127_609268_4 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 466.0
TLS2_k127_609268_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 426.0
TLS2_k127_609268_6 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 370.0
TLS2_k127_609268_7 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 366.0
TLS2_k127_609268_8 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 338.0
TLS2_k127_609268_9 (Fe-S) oxidoreductase K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 337.0
TLS2_k127_6103233_0 Cysteine-rich domain - - - 6.061e-210 660.0
TLS2_k127_6103233_1 COG1592 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002108 263.0
TLS2_k127_6103233_10 Transcriptional regulator - - - 0.000000000001297 78.0
TLS2_k127_6103233_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.000002443 50.0
TLS2_k127_6103233_2 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000225 267.0
TLS2_k127_6103233_3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003872 251.0
TLS2_k127_6103233_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000174 234.0
TLS2_k127_6103233_5 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000886 227.0
TLS2_k127_6103233_6 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000000000001648 228.0
TLS2_k127_6103233_7 Belongs to the Fur family K09826 - - 0.000000000000000000000000000000000000000000000000000003227 193.0
TLS2_k127_6103233_8 Lactoylglutathione lyase K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000002336 188.0
TLS2_k127_6103233_9 Polysaccharide pyruvyl transferase - - - 0.00000000000000000000000000000000003225 149.0
TLS2_k127_6104144_0 transport system, fused permease components - - - 3.723e-289 908.0
TLS2_k127_6104144_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 3.941e-261 814.0
TLS2_k127_6104144_10 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 424.0
TLS2_k127_6104144_11 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005873 379.0
TLS2_k127_6104144_12 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 387.0
TLS2_k127_6104144_13 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 376.0
TLS2_k127_6104144_14 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 375.0
TLS2_k127_6104144_15 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004014 362.0
TLS2_k127_6104144_16 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 353.0
TLS2_k127_6104144_17 serine threonine protein kinase K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003081 297.0
TLS2_k127_6104144_18 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005055 251.0
TLS2_k127_6104144_19 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000003717 239.0
TLS2_k127_6104144_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 1.516e-205 653.0
TLS2_k127_6104144_20 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.000000000000000000000000000000000000000000000000000005845 203.0
TLS2_k127_6104144_21 Protein of unknown function (DUF459) K09795 - - 0.000000000000000000000000000000000000000003788 165.0
TLS2_k127_6104144_22 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000008597 156.0
TLS2_k127_6104144_23 NMT1-like family K07080 - - 0.00000000000000000000000000000000004182 148.0
TLS2_k127_6104144_24 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.00000000000000000000000000008884 120.0
TLS2_k127_6104144_25 Domain of unknown function (DUF1850) - - - 0.00000000009884 70.0
TLS2_k127_6104144_27 Major Facilitator Superfamily - - - 0.000001164 51.0
TLS2_k127_6104144_28 TraY domain K18918 - - 0.00000142 52.0
TLS2_k127_6104144_3 Bacterial extracellular solute-binding protein K05813 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 607.0
TLS2_k127_6104144_4 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 610.0
TLS2_k127_6104144_5 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 551.0
TLS2_k127_6104144_6 MBOAT, membrane-bound O-acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 513.0
TLS2_k127_6104144_7 transport system periplasmic component K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 455.0
TLS2_k127_6104144_8 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816 - 3.6.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 448.0
TLS2_k127_6104144_9 Binding-protein-dependent transport system inner membrane component K05814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 416.0
TLS2_k127_6133101_0 NAD-specific glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1272.0
TLS2_k127_6133101_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 5.985e-236 739.0
TLS2_k127_6133101_2 Polysaccharide biosynthesis protein K13013 - - 6.033e-212 676.0
TLS2_k127_6133101_3 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 435.0
TLS2_k127_6133101_4 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 440.0
TLS2_k127_6133101_5 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 315.0
TLS2_k127_6133101_6 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase K02851,K13007 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 294.0
TLS2_k127_6133101_7 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000001683 176.0
TLS2_k127_6133101_8 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000001354 141.0
TLS2_k127_6155452_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.087e-234 737.0
TLS2_k127_6155452_1 cell division K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 310.0
TLS2_k127_6155452_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000006058 216.0
TLS2_k127_6155452_3 Cell division protein K09811 - - 0.00000000000000000000000000000000000000000000000000000002098 226.0
TLS2_k127_6155452_4 DUF218 domain - - - 0.00000000000000000000000000000009126 133.0
TLS2_k127_6155452_5 TIGRFAM MJ0042 family finger-like - - - 0.0000000000000000000000007894 114.0
TLS2_k127_6155452_6 PFAM Pentapeptide repeats (8 copies) - - - 0.00000000000000000000008683 105.0
TLS2_k127_6156755_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 7.785e-236 752.0
TLS2_k127_6156755_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.744e-232 728.0
TLS2_k127_6156755_10 Udp N-acetylglucosamine O-acyltransferase; Domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 324.0
TLS2_k127_6156755_11 structural constituent of ribosome K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 321.0
TLS2_k127_6156755_12 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 321.0
TLS2_k127_6156755_13 Phytanoyl-CoA dioxygenase (PhyH) K21195 - 1.14.11.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 304.0
TLS2_k127_6156755_14 protein conserved in bacteria K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 299.0
TLS2_k127_6156755_15 MobA-like NTP transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000915 286.0
TLS2_k127_6156755_16 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004763 255.0
TLS2_k127_6156755_17 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000000000000001454 248.0
TLS2_k127_6156755_18 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000009754 237.0
TLS2_k127_6156755_19 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000001864 234.0
TLS2_k127_6156755_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 3.141e-194 625.0
TLS2_k127_6156755_20 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000002849 208.0
TLS2_k127_6156755_21 cheY-homologous receiver domain K11443 - - 0.000000000000000000000000000000000000000000008018 165.0
TLS2_k127_6156755_22 Competence protein K02238 - - 0.0000000000000000000000000000000000000000007738 164.0
TLS2_k127_6156755_23 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000002958 171.0
TLS2_k127_6156755_24 COG2825 Outer membrane protein - - - 0.00000001101 64.0
TLS2_k127_6156755_3 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 505.0
TLS2_k127_6156755_4 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007638 418.0
TLS2_k127_6156755_5 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 389.0
TLS2_k127_6156755_6 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 394.0
TLS2_k127_6156755_7 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 351.0
TLS2_k127_6156755_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 337.0
TLS2_k127_6156755_9 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 341.0
TLS2_k127_6156841_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.452e-224 703.0
TLS2_k127_6156841_1 tRNA synthetases class I (I, L, M and V) K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 584.0
TLS2_k127_6156841_10 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000007747 191.0
TLS2_k127_6156841_11 Uncharacterised protein family (UPF0093) K08973 - - 0.000000000000000000000000000000000000000000000006708 176.0
TLS2_k127_6156841_12 FR47-like protein - - - 0.0000000000000000000000000000000000000000000002128 181.0
TLS2_k127_6156841_13 Domain of unknown function (DUF3576) - - - 0.000000000000000000000001851 115.0
TLS2_k127_6156841_14 [2Fe-2S] binding domain K00256,K07302 - 1.3.99.16 0.0000000000002254 79.0
TLS2_k127_6156841_2 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 361.0
TLS2_k127_6156841_3 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 332.0
TLS2_k127_6156841_4 transcriptional regulator K04761 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 332.0
TLS2_k127_6156841_5 Pyridoxal-phosphate dependent enzyme K17989 - 4.3.1.17,4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 333.0
TLS2_k127_6156841_6 Peroxiredoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 282.0
TLS2_k127_6156841_7 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001777 273.0
TLS2_k127_6156841_8 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000001587 276.0
TLS2_k127_6156841_9 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K04756 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004747 246.0
TLS2_k127_6167052_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 2.386e-202 648.0
TLS2_k127_6167052_1 TRAP transporter, 4TM 12TM fusion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 565.0
TLS2_k127_6167052_2 COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 337.0
TLS2_k127_6167052_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 326.0
TLS2_k127_6167052_4 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000000000000000000000000005492 223.0
TLS2_k127_6167052_5 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000001078 216.0
TLS2_k127_6167052_6 response regulator receiver K13041 - - 0.000000000000000000000000000000000000000000000000000001618 201.0
TLS2_k127_6167052_7 regulation of DNA-templated transcription, elongation - - - 0.000000000000000000000000000000000000000000000001603 191.0
TLS2_k127_6167052_8 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000006124 128.0
TLS2_k127_6227091_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 2.753e-302 945.0
TLS2_k127_6227091_1 Protein conserved in bacteria - - - 3.272e-205 651.0
TLS2_k127_6227091_10 DNA-binding transcription factor activity K03710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001349 255.0
TLS2_k127_6227091_11 KR domain K13774 - - 0.00000000000000000000000000000000000000000000000000000000000000000006159 240.0
TLS2_k127_6227091_12 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000002836 143.0
TLS2_k127_6227091_13 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000001187 121.0
TLS2_k127_6227091_14 - - - - 0.0000000000000000000000002267 115.0
TLS2_k127_6227091_15 Response regulator receiver - - - 0.000000000000000000000005012 106.0
TLS2_k127_6227091_16 N-formylglutamate amidohydrolase - - - 0.00000000000000000000003391 109.0
TLS2_k127_6227091_17 Transposase - - - 0.0004549 51.0
TLS2_k127_6227091_2 Belongs to the FGGY kinase family K00854 - 2.7.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 546.0
TLS2_k127_6227091_3 Periplasmic binding protein domain K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 480.0
TLS2_k127_6227091_4 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 461.0
TLS2_k127_6227091_5 TIM-barrel enzyme K06971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 411.0
TLS2_k127_6227091_6 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 362.0
TLS2_k127_6227091_7 ABC-type sugar transport system, ATPase component K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 349.0
TLS2_k127_6227091_8 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 295.0
TLS2_k127_6227091_9 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002692 284.0
TLS2_k127_6238720_0 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006044 566.0
TLS2_k127_6238720_1 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 443.0
TLS2_k127_6238720_2 ABC-type Fe3 transport system permease component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 332.0
TLS2_k127_6238720_3 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000001688 185.0
TLS2_k127_6238720_4 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 0.000000000000000000000000000000000028 153.0
TLS2_k127_6238720_5 Belongs to the ABC transporter superfamily K02010,K02052 - 3.6.3.30 0.00000005841 56.0
TLS2_k127_6270472_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.981e-248 780.0
TLS2_k127_6270472_1 Asparagine synthase K01953 - 6.3.5.4 9.513e-197 628.0
TLS2_k127_6270472_2 Belongs to the HpcH HpaI aldolase family K08691 - 4.1.3.24,4.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 498.0
TLS2_k127_6270472_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 472.0
TLS2_k127_6270472_4 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.000000000000000000000000000000000000001872 153.0
TLS2_k127_628182_0 PAS fold K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 317.0
TLS2_k127_628182_1 NMT1/THI5 like K02051 - - 0.00000000000000000000003144 102.0
TLS2_k127_6297879_0 COG1840 ABC-type Fe3 transport system, periplasmic component K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 548.0
TLS2_k127_6297879_1 Belongs to the ABC transporter superfamily K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 480.0
TLS2_k127_6297879_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000001503 168.0
TLS2_k127_6297879_11 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000000000000000000573 134.0
TLS2_k127_6297879_12 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000000000000000000000000003555 124.0
TLS2_k127_6297879_13 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000001204 90.0
TLS2_k127_6297879_14 OmpA family K03286 - - 0.00001721 57.0
TLS2_k127_6297879_2 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 449.0
TLS2_k127_6297879_3 Binding-protein-dependent transport system inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 399.0
TLS2_k127_6297879_4 Binding-protein-dependent transport system inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 388.0
TLS2_k127_6297879_5 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 354.0
TLS2_k127_6297879_6 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005823 338.0
TLS2_k127_6297879_7 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 346.0
TLS2_k127_6297879_8 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 335.0
TLS2_k127_6297879_9 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000000000000007948 192.0
TLS2_k127_6312437_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K02182 - 6.2.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 588.0
TLS2_k127_6312437_1 Pfam:Pyridox_oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006412 452.0
TLS2_k127_6312437_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 361.0
TLS2_k127_6312437_3 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 332.0
TLS2_k127_6312437_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 302.0
TLS2_k127_6312437_5 Activator of Hsp90 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005541 273.0
TLS2_k127_6312437_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000001799 138.0
TLS2_k127_6312437_7 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000002939 65.0
TLS2_k127_6313980_0 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 2.76e-243 777.0
TLS2_k127_6313980_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 539.0
TLS2_k127_6313980_10 In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold. - - - 0.0000000000000000000000000000000000000000000000000001334 190.0
TLS2_k127_6313980_11 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000006875 193.0
TLS2_k127_6313980_13 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000285 160.0
TLS2_k127_6313980_14 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000001702 142.0
TLS2_k127_6313980_15 EVE domain - - - 0.00000000000000000000000000000000191 135.0
TLS2_k127_6313980_16 - - - - 0.0000000000000000000000000003858 119.0
TLS2_k127_6313980_17 DNA-binding transcription factor activity K03741,K03892 - 1.20.4.1 0.0000000000000000000001103 104.0
TLS2_k127_6313980_18 Sporulation related domain - - - 0.000000000005736 79.0
TLS2_k127_6313980_2 PFAM NAD-dependent epimerase dehydratase K01710,K01784 - 4.2.1.46,5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 433.0
TLS2_k127_6313980_3 COG0708 Exonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 392.0
TLS2_k127_6313980_4 COG0367 Asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004222 397.0
TLS2_k127_6313980_5 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 316.0
TLS2_k127_6313980_6 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003834 270.0
TLS2_k127_6313980_7 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007493 276.0
TLS2_k127_6313980_8 Winged helix-turn-helix DNA-binding - - - 0.00000000000000000000000000000000000000000000000000001732 196.0
TLS2_k127_6313980_9 PFAM Transposase IS200 like - - - 0.00000000000000000000000000000000000000000000000000005668 195.0
TLS2_k127_6334118_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K04108 - 1.3.7.9 2.36e-291 923.0
TLS2_k127_6334118_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 4.461e-216 682.0
TLS2_k127_6334118_10 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 344.0
TLS2_k127_6334118_11 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K04109,K11178 - 1.17.1.4,1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 344.0
TLS2_k127_6334118_12 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 341.0
TLS2_k127_6334118_13 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 296.0
TLS2_k127_6334118_14 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 291.0
TLS2_k127_6334118_15 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 288.0
TLS2_k127_6334118_16 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006481 304.0
TLS2_k127_6334118_17 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002953 277.0
TLS2_k127_6334118_18 [2Fe-2S] binding domain K04107 - 1.3.7.9 0.000000000000000000000000000000000000000000000000000000002466 204.0
TLS2_k127_6334118_19 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000001938 183.0
TLS2_k127_6334118_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 586.0
TLS2_k127_6334118_20 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000131 166.0
TLS2_k127_6334118_21 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000006441 149.0
TLS2_k127_6334118_22 EamA-like transporter family - - - 0.00000000000000000000000000000103 134.0
TLS2_k127_6334118_23 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00003538 47.0
TLS2_k127_6334118_3 (ABC) transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 609.0
TLS2_k127_6334118_4 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 540.0
TLS2_k127_6334118_5 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 522.0
TLS2_k127_6334118_6 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K01782,K07516 - 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 499.0
TLS2_k127_6334118_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009808 455.0
TLS2_k127_6334118_8 ubiquitin protein ligase binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009871 397.0
TLS2_k127_6334118_9 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 386.0
TLS2_k127_6367835_0 Belongs to the ClpA ClpB family K03694 - - 0.0 1184.0
TLS2_k127_6367835_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 2.954e-219 686.0
TLS2_k127_6367835_2 phosphomannomutase K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000792 499.0
TLS2_k127_6367835_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 460.0
TLS2_k127_6367835_4 UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 402.0
TLS2_k127_6367835_5 Belongs to the peptidase S11 family K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000004849 226.0
TLS2_k127_6367835_6 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000000000000007104 180.0
TLS2_k127_6367835_7 - - - - 0.00000000000000000000000005837 109.0
TLS2_k127_6367835_8 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000617 78.0
TLS2_k127_6367835_9 phasin family - - - 0.00000000001008 74.0
TLS2_k127_638970_0 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K05559,K05565 - - 0.0 1382.0
TLS2_k127_638970_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 9.11e-286 886.0
TLS2_k127_638970_10 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 407.0
TLS2_k127_638970_11 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 398.0
TLS2_k127_638970_12 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 386.0
TLS2_k127_638970_13 COG2513 PEP phosphonomutase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003735 376.0
TLS2_k127_638970_14 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 352.0
TLS2_k127_638970_15 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 316.0
TLS2_k127_638970_16 Domain of unknown function (DUF4743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 306.0
TLS2_k127_638970_17 MASE1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002671 299.0
TLS2_k127_638970_18 alpha/beta hydrolase fold K01066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002319 258.0
TLS2_k127_638970_19 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000003027 239.0
TLS2_k127_638970_2 COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05561,K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 589.0
TLS2_k127_638970_20 Inosine-uridine preferring nucleoside hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000695 250.0
TLS2_k127_638970_21 Protein of unknown function (DUF2817) - - - 0.000000000000000000000000000000000000000000000000000000000000002381 228.0
TLS2_k127_638970_22 Pfam SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000005557 211.0
TLS2_k127_638970_23 COG1863 Multisubunit Na H antiporter, MnhE subunit K05562 - - 0.00000000000000000000000000000000000000000000000000000001333 222.0
TLS2_k127_638970_24 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000000000002382 186.0
TLS2_k127_638970_25 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000008902 190.0
TLS2_k127_638970_26 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000001057 197.0
TLS2_k127_638970_27 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000001457 187.0
TLS2_k127_638970_28 Phospholipid methyltransferase - - - 0.000000000000000000000000000000000000000000000002721 177.0
TLS2_k127_638970_29 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000009436 178.0
TLS2_k127_638970_3 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 549.0
TLS2_k127_638970_30 COG1006 Multisubunit Na H antiporter, MnhC subunit K05560 - - 0.0000000000000000000000000000000000000000204 157.0
TLS2_k127_638970_31 PFAM Na H antiporter subunit K05564 - - 0.000000000000000000000000000000000003391 140.0
TLS2_k127_638970_32 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000001506 136.0
TLS2_k127_638970_33 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000000000199 130.0
TLS2_k127_638970_34 COG2212 Multisubunit Na H antiporter, MnhF subunit K05563 - - 0.000000000000000000000000000004004 130.0
TLS2_k127_638970_35 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000004375 82.0
TLS2_k127_638970_36 Protein of unknown function DUF86 - - - 0.000000000000623 73.0
TLS2_k127_638970_38 Transposase DDE domain - - - 0.000000002332 61.0
TLS2_k127_638970_4 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 538.0
TLS2_k127_638970_5 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 531.0
TLS2_k127_638970_6 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 505.0
TLS2_k127_638970_7 Belongs to the arginase family K01476,K18459 - 3.5.3.1,3.5.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 493.0
TLS2_k127_638970_8 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 498.0
TLS2_k127_638970_9 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 449.0
TLS2_k127_6400726_0 FAD dependent oxidoreductase - - - 0.0 1166.0
TLS2_k127_6400726_1 Iron-containing alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 600.0
TLS2_k127_6400726_2 Na+/Pi-cotransporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 376.0
TLS2_k127_6400726_3 PFAM Aldehyde dehydrogenase K00128 - 1.2.1.3 0.00000000000000000000000000000000000000001451 153.0
TLS2_k127_6490074_0 Belongs to the thiolase family K00626,K00632,K07823 - 2.3.1.16,2.3.1.174,2.3.1.9 2.453e-194 612.0
TLS2_k127_6490074_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005345 487.0
TLS2_k127_6490074_10 Two component regulator propeller - - - 0.000000000008314 77.0
TLS2_k127_6490074_11 Aldo/keto reductase family - - - 0.000000000101 66.0
TLS2_k127_6490074_12 - - - - 0.000000006469 69.0
TLS2_k127_6490074_2 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 438.0
TLS2_k127_6490074_3 including yeast histone deacetylase and acetoin utilization protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 400.0
TLS2_k127_6490074_4 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 293.0
TLS2_k127_6490074_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001221 254.0
TLS2_k127_6490074_6 Phenylacetic acid degradation protein PaaY K08279 - - 0.00000000000000000000000000000000000000000000000000000000000001953 222.0
TLS2_k127_6490074_7 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000000004811 154.0
TLS2_k127_6490074_8 COG3668 Plasmid stabilization system protein - - - 0.00000000000000000000000000000000001172 141.0
TLS2_k127_6490074_9 phenylacetic acid degradation protein paaD K02614 - - 0.000000000000000000000000000000000705 138.0
TLS2_k127_6510489_0 transport system fused permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 451.0
TLS2_k127_6510489_1 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000009268 97.0
TLS2_k127_6510489_2 PFAM Glycosyl transferase, group 1 K13668 - 2.4.1.346 0.0004395 45.0
TLS2_k127_6521791_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.825e-213 675.0
TLS2_k127_6521791_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 3.354e-202 643.0
TLS2_k127_6521791_10 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000002164 250.0
TLS2_k127_6521791_11 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001913 243.0
TLS2_k127_6521791_12 ChrR Cupin-like domain - - - 0.0000000000000000000000000000000000000000004473 161.0
TLS2_k127_6521791_13 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000002366 166.0
TLS2_k127_6521791_14 COG3090 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000000000000000000000000000000000462 146.0
TLS2_k127_6521791_15 - - - - 0.0000000000000000000000000000002364 133.0
TLS2_k127_6521791_16 protein conserved in bacteria K01227,K01447,K01448,K06385,K07260,K11060,K11062,K21472 - 3.2.1.96,3.4.17.14,3.5.1.28 0.0000000002015 69.0
TLS2_k127_6521791_2 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003858 586.0
TLS2_k127_6521791_3 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 521.0
TLS2_k127_6521791_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000744 477.0
TLS2_k127_6521791_5 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 469.0
TLS2_k127_6521791_6 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009887 422.0
TLS2_k127_6521791_7 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 400.0
TLS2_k127_6521791_8 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 397.0
TLS2_k127_6521791_9 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 304.0
TLS2_k127_6525890_0 COG1024 Enoyl-CoA hydratase carnithine racemase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 387.0
TLS2_k127_6525890_1 Major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 390.0
TLS2_k127_6525890_2 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000009897 181.0
TLS2_k127_6525890_3 Scavenger mRNA decapping enzyme C-term binding - - - 0.000000000000000000000000001961 116.0
TLS2_k127_6525890_4 Scavenger mRNA decapping enzyme C-term binding - - - 0.000000000000002829 80.0
TLS2_k127_6530452_0 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 6.183e-246 767.0
TLS2_k127_6530452_1 cysteine synthase K01697 - 4.2.1.22 1.324e-195 647.0
TLS2_k127_6530452_2 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 1.656e-195 627.0
TLS2_k127_6530452_3 cystathionine K01739,K01758 - 2.5.1.48,4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 584.0
TLS2_k127_6530452_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 353.0
TLS2_k127_6530452_5 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.0000000000000000000000000000000000000000000000000000000000004931 215.0
TLS2_k127_6530452_6 response to hydrogen peroxide - - - 0.0000000001107 67.0
TLS2_k127_6530452_7 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.0001791 53.0
TLS2_k127_6540277_0 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000003266 240.0
TLS2_k127_6540277_1 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000002905 128.0
TLS2_k127_6540277_2 Thioredoxin-like domain - - - 0.00000000000000000000007858 103.0
TLS2_k127_6540277_3 - - - - 0.000000000002542 77.0
TLS2_k127_6549717_0 NfeD-like C-terminal, partner-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 426.0
TLS2_k127_6549717_1 SPFH Band 7 PHB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 344.0
TLS2_k127_6549717_2 Stimulus-sensing domain K14980 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008755 275.0
TLS2_k127_6549717_3 Membrane transport protein K07088 - - 0.00000000000000000000000001748 113.0
TLS2_k127_6549717_4 oxidoreductase activity K03366 - 1.1.1.304,1.1.1.76 0.00003106 49.0
TLS2_k127_6555624_0 Bacterial protein of unknown function (DUF899) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 447.0
TLS2_k127_6555624_1 Protein of unknown function (DUF808) K09781 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 428.0
TLS2_k127_6555624_10 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 - - 0.000000000000000000000000000000000009889 148.0
TLS2_k127_6555624_11 Bacterial protein of unknown function (DUF899) - - - 0.000000000001341 68.0
TLS2_k127_6555624_12 Transcriptional regulatory protein, C terminal - - - 0.0006373 44.0
TLS2_k127_6555624_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009842 321.0
TLS2_k127_6555624_3 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 298.0
TLS2_k127_6555624_4 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 309.0
TLS2_k127_6555624_5 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 300.0
TLS2_k127_6555624_6 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006798 312.0
TLS2_k127_6555624_7 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002614 300.0
TLS2_k127_6555624_8 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003199 281.0
TLS2_k127_6555624_9 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000001608 175.0
TLS2_k127_6570611_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.88e-300 931.0
TLS2_k127_6570611_1 transport system fused permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 521.0
TLS2_k127_6570611_10 HIUase/Transthyretin family - - - 0.00000000000000001251 93.0
TLS2_k127_6570611_2 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 439.0
TLS2_k127_6570611_3 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 395.0
TLS2_k127_6570611_4 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 326.0
TLS2_k127_6570611_5 TRAP transporter solute receptor TAXI family protein K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004641 252.0
TLS2_k127_6570611_6 VanZ like family - - - 0.000000000000000000000000000000000000004076 149.0
TLS2_k127_6570611_7 - - - - 0.00000000000000000000000000000000004596 142.0
TLS2_k127_6570611_8 Transcriptional regulator - - - 0.000000000000000000000000000001009 126.0
TLS2_k127_6570611_9 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000002756 124.0
TLS2_k127_6583126_0 GDP-mannose 4,6 dehydratase K08678 - 4.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 504.0
TLS2_k127_6583126_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 404.0
TLS2_k127_6583126_10 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000004473 178.0
TLS2_k127_6583126_11 Transport permease protein K09690 - - 0.00000000000000000000000000000000000000444 163.0
TLS2_k127_6583126_12 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis K00720 - 2.4.1.80 0.0000000000000000000000008053 121.0
TLS2_k127_6583126_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 398.0
TLS2_k127_6583126_3 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005897 355.0
TLS2_k127_6583126_4 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 326.0
TLS2_k127_6583126_5 acetyltransferase - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009409 286.0
TLS2_k127_6583126_6 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000014 220.0
TLS2_k127_6583126_7 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000005031 214.0
TLS2_k127_6583126_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000227 197.0
TLS2_k127_6583126_9 YdjC-like protein K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000000000000001083 197.0
TLS2_k127_659797_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 2.259e-276 863.0
TLS2_k127_659797_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 406.0
TLS2_k127_659797_10 Voltage gated chloride channel K03281 - - 0.00000000001071 69.0
TLS2_k127_659797_11 - - - - 0.0000000002799 64.0
TLS2_k127_659797_2 transduction histidine kinase K07716 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 339.0
TLS2_k127_659797_3 MlaA lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000009755 235.0
TLS2_k127_659797_4 Sodium Bile acid symporter family - - - 0.000000000000000000000000000000000000000000000886 177.0
TLS2_k127_659797_5 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000000000000006978 165.0
TLS2_k127_659797_6 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.00000000000000000000000000000000003768 144.0
TLS2_k127_659797_7 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.0000000000000000000000000002091 124.0
TLS2_k127_659797_8 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.00000000000000000001744 100.0
TLS2_k127_659797_9 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.0000000000000003247 80.0
TLS2_k127_6649148_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 402.0
TLS2_k127_6649148_1 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004889 398.0
TLS2_k127_6649148_10 GDP-mannose 4,6-dehydratase activity K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 320.0
TLS2_k127_6649148_11 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 310.0
TLS2_k127_6649148_12 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 338.0
TLS2_k127_6649148_13 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 298.0
TLS2_k127_6649148_14 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 297.0
TLS2_k127_6649148_15 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008819 284.0
TLS2_k127_6649148_16 Class II aldolase adducin family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002417 292.0
TLS2_k127_6649148_17 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005564 249.0
TLS2_k127_6649148_18 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002635 251.0
TLS2_k127_6649148_19 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000001904 265.0
TLS2_k127_6649148_2 COG2513 PEP phosphonomutase and related enzymes K20454 - 4.1.3.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 393.0
TLS2_k127_6649148_20 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000000000000000003681 220.0
TLS2_k127_6649148_21 Rieske 2Fe-2S - - - 0.000000000000000000000000000000000000000000000000000000000000005041 224.0
TLS2_k127_6649148_22 COG2513 PEP phosphonomutase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000004396 218.0
TLS2_k127_6649148_23 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000002689 211.0
TLS2_k127_6649148_24 Predicted membrane protein (DUF2231) - - - 0.00000000000000000000000000000000000000000000000000006725 193.0
TLS2_k127_6649148_25 - - - - 0.0000000000000000000000000000000000000000000000000478 197.0
TLS2_k127_6649148_26 Low affinity iron permease - - - 0.000000000000000000000000000000000000000003449 169.0
TLS2_k127_6649148_27 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000423 163.0
TLS2_k127_6649148_28 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000002703 127.0
TLS2_k127_6649148_29 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000003091 135.0
TLS2_k127_6649148_3 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 375.0
TLS2_k127_6649148_30 Cytochrome c K08738 - - 0.00000000000000000000000000003634 124.0
TLS2_k127_6649148_31 - - - - 0.000000000000000000000000001434 114.0
TLS2_k127_6649148_32 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 0.0000000000657 63.0
TLS2_k127_6649148_33 COG2931 RTX toxins and related Ca2 -binding proteins K01406,K07004 - 3.4.24.40 0.00001802 57.0
TLS2_k127_6649148_4 Benzoate membrane transport protein K05782 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 368.0
TLS2_k127_6649148_5 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 349.0
TLS2_k127_6649148_6 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 336.0
TLS2_k127_6649148_7 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 330.0
TLS2_k127_6649148_8 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 334.0
TLS2_k127_6649148_9 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 332.0
TLS2_k127_6656965_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 6.899e-223 716.0
TLS2_k127_6656965_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 3.43e-200 640.0
TLS2_k127_6656965_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000002402 134.0
TLS2_k127_6656965_11 Domain of unknown function (DUF1989) - - - 0.00000000000000000000000000000007025 135.0
TLS2_k127_6656965_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000001104 126.0
TLS2_k127_6656965_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 452.0
TLS2_k127_6656965_3 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008275 399.0
TLS2_k127_6656965_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 392.0
TLS2_k127_6656965_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008551 269.0
TLS2_k127_6656965_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001739 256.0
TLS2_k127_6656965_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003023 240.0
TLS2_k127_6656965_8 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000223 160.0
TLS2_k127_6656965_9 Ring hydroxylating beta subunit - - - 0.0000000000000000000000000000000007983 144.0
TLS2_k127_666842_0 COG0480 Translation elongation factors (GTPases) K02355 - - 3.258e-260 818.0
TLS2_k127_666842_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008974 564.0
TLS2_k127_666842_2 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768,K01769 - 4.6.1.1,4.6.1.2 0.00000000000000000000000000000000000000000000000000006467 204.0
TLS2_k127_666842_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000358 174.0
TLS2_k127_666842_4 ribonuclease - GO:0005575,GO:0005576 - 0.0000000000000000000000000000002098 131.0
TLS2_k127_666842_5 Carboxyl transferase domain - - - 0.000000000000000000000000004947 114.0
TLS2_k127_666842_6 Barstar (barnase inhibitor) K03623 - - 0.000000000009608 75.0
TLS2_k127_6672959_0 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 342.0
TLS2_k127_6672959_1 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 306.0
TLS2_k127_6672959_2 COG0314 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000001152 215.0
TLS2_k127_6672959_3 Family of unknown function (DUF695) - - - 0.000000000000000000000000000000000000000000002228 172.0
TLS2_k127_6672959_4 Putative DNA-binding domain - - - 0.000000000000000000000000000000000006038 147.0
TLS2_k127_6672959_5 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000000000000000000000000502 120.0
TLS2_k127_6672959_6 DoxX K15977 - - 0.0000000000000000000003728 110.0
TLS2_k127_6672959_7 Predicted integral membrane protein (DUF2282) - - - 0.000000000000001379 80.0
TLS2_k127_6672959_8 Predicted integral membrane protein (DUF2282) - - - 0.000000002643 63.0
TLS2_k127_6672959_9 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.00000257 50.0
TLS2_k127_6675595_0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 358.0
TLS2_k127_6675595_1 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000009199 237.0
TLS2_k127_6675595_2 hydroperoxide reductase activity K07486 - - 0.000000000000000000000000000000000000000000000000000000000271 220.0
TLS2_k127_6675595_3 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.0000000000000000000003049 105.0
TLS2_k127_6675595_4 - - - - 0.000000000000000000001128 102.0
TLS2_k127_6675595_5 LTXXQ motif family protein - - - 0.000000000000000001063 96.0
TLS2_k127_6675595_6 Protein of unknown function (DUF2933) - - - 0.0000000000000002073 88.0
TLS2_k127_6675595_7 Cytochrome C oxidase subunit I K02274 - 1.9.3.1 0.0000001449 62.0
TLS2_k127_667660_0 Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 511.0
TLS2_k127_667660_1 Belongs to the type-B carboxylesterase lipase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 324.0
TLS2_k127_667660_2 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000001104 241.0
TLS2_k127_67409_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.526e-245 763.0
TLS2_k127_67409_1 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 357.0
TLS2_k127_67409_2 COG2893 Phosphotransferase system, mannose fructose-specific component IIA K02793 - 2.7.1.191 0.00000000000000000000000000000000000000000000000000000004472 199.0
TLS2_k127_67409_3 pfam morn - - - 0.0000000000000000000000000000346 126.0
TLS2_k127_67409_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.000000000000000000000000003091 120.0
TLS2_k127_67409_5 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.00000000000000000758 87.0
TLS2_k127_67409_6 - K21495 - - 0.0000000001939 67.0
TLS2_k127_67409_7 Terminase small subunit K07474 - - 0.00000008759 64.0
TLS2_k127_6741855_0 COG1233 Phytoene dehydrogenase and related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000729 590.0
TLS2_k127_6741855_1 C-terminal domain of 1-Cys peroxiredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 374.0
TLS2_k127_6741855_2 AMP-binding enzyme C-terminal domain K04110,K20458 - 6.2.1.25,6.2.1.27,6.2.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 373.0
TLS2_k127_6741855_3 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000009121 189.0
TLS2_k127_6741855_4 SnoaL-like domain - - - 0.00000000000000000000000001099 126.0
TLS2_k127_675522_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K09461 - 1.14.13.40 2.834e-269 871.0
TLS2_k127_675522_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K08295 - 6.2.1.32 1.392e-213 679.0
TLS2_k127_675522_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000002548 73.0
TLS2_k127_6774102_0 Domain of unknown function (DUF3362) - - - 2.396e-252 781.0
TLS2_k127_6774102_1 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 369.0
TLS2_k127_6774102_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 333.0
TLS2_k127_6774102_3 - - - - 0.0000000000000000000000000000000000000000000000000000000001001 209.0
TLS2_k127_6774102_4 SnoaL-like domain - - - 0.0000000000000000000000000000004783 129.0
TLS2_k127_6774102_5 - - - - 0.00000000000000000000000001335 116.0
TLS2_k127_6774102_6 Transglycosylase associated protein - - - 0.00000001996 57.0
TLS2_k127_6778126_0 N-acetyl sugar amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009095 556.0
TLS2_k127_6778126_1 Belongs to the pyruvate kinase family K00873,K00958 - 2.7.1.40,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 560.0
TLS2_k127_6778126_2 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 476.0
TLS2_k127_6778126_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000137 299.0
TLS2_k127_6778126_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00612 - - 0.00000000000000000000000000000000000000000000000000000000000004975 224.0
TLS2_k127_6778126_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000000006671 192.0
TLS2_k127_6778126_6 Adenylylsulphate kinase K00860 - 2.7.1.25 0.0000000000000000000000000000000000004403 155.0
TLS2_k127_6778126_7 Sulfatase - - - 0.00000000000004171 85.0
TLS2_k127_678692_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1041.0
TLS2_k127_678692_1 transport system, fused permease components - - - 0.0 1024.0
TLS2_k127_678692_2 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009223 279.0
TLS2_k127_678692_3 Aminotransferase K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002825 258.0
TLS2_k127_678692_4 FecR protein - - - 0.00000000000000000000000000000004939 137.0
TLS2_k127_678692_5 Transglycosylase associated protein - - - 0.00000000000000000000007397 100.0
TLS2_k127_678692_6 - - - - 0.00006424 50.0
TLS2_k127_6789628_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 3.867e-208 660.0
TLS2_k127_6789628_1 Belongs to the sigma-70 factor family K03088 - - 9.62e-206 647.0
TLS2_k127_6789628_10 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000145 185.0
TLS2_k127_6789628_11 AsmA family K07289,K07290 - - 0.00000000000000000000000000000000000000000000002193 195.0
TLS2_k127_6789628_12 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.0000000000000000000000000000000000000000000002566 177.0
TLS2_k127_6789628_13 SnoaL-like domain K04750 - - 0.000000000000000000000000000000000000007483 149.0
TLS2_k127_6789628_14 YCII-related domain - - - 0.0000000000000000000000000000000000009524 148.0
TLS2_k127_6789628_15 Domain of unknown function (DUF427) - - - 0.000000000000000000000000000001903 129.0
TLS2_k127_6789628_16 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000006644 118.0
TLS2_k127_6789628_17 - - - - 0.0000000000000002202 87.0
TLS2_k127_6789628_18 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 0.00000000000000362 76.0
TLS2_k127_6789628_2 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 2.592e-204 667.0
TLS2_k127_6789628_3 Belongs to the peptidase S1C family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009974 429.0
TLS2_k127_6789628_4 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 382.0
TLS2_k127_6789628_5 Bacterial protein of unknown function (DUF899) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009376 337.0
TLS2_k127_6789628_6 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 333.0
TLS2_k127_6789628_7 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000002859 239.0
TLS2_k127_6789628_8 COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000003237 219.0
TLS2_k127_6789628_9 Ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000000000000000000000000003106 199.0
TLS2_k127_6836071_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.0 1066.0
TLS2_k127_6836071_1 Xanthine dehydrogenase K13482 - 1.17.1.4 1.262e-308 963.0
TLS2_k127_6836071_10 [2Fe-2S] binding domain K13481 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007118 497.0
TLS2_k127_6836071_11 Amidase K02433,K21801 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 478.0
TLS2_k127_6836071_12 Peptidase family M28 K02083 - 3.5.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 473.0
TLS2_k127_6836071_13 Phosphoenolpyruvate hydrolase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 457.0
TLS2_k127_6836071_14 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 447.0
TLS2_k127_6836071_15 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 428.0
TLS2_k127_6836071_16 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 418.0
TLS2_k127_6836071_17 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 389.0
TLS2_k127_6836071_18 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 383.0
TLS2_k127_6836071_19 COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain K02030,K10022 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 371.0
TLS2_k127_6836071_2 Uncharacterised protein family (UPF0261) - - - 4.076e-305 953.0
TLS2_k127_6836071_20 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 347.0
TLS2_k127_6836071_21 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 351.0
TLS2_k127_6836071_22 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 342.0
TLS2_k127_6836071_23 TAP-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 316.0
TLS2_k127_6836071_24 ABC-type amino acid transport system, permease component K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 321.0
TLS2_k127_6836071_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 299.0
TLS2_k127_6836071_26 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 296.0
TLS2_k127_6836071_27 COG2309 Leucyl aminopeptidase (aminopeptidase T) K18028 - 1.13.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000002013 252.0
TLS2_k127_6836071_28 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000001677 242.0
TLS2_k127_6836071_29 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000004614 239.0
TLS2_k127_6836071_3 Amidohydrolase family - - - 1.435e-238 744.0
TLS2_k127_6836071_30 Xanthine dehydrogenase K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000902 254.0
TLS2_k127_6836071_31 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000001526 233.0
TLS2_k127_6836071_32 PFAM CMP dCMP deaminase zinc-binding K01487 - 3.5.4.3 0.000000000000000000000000000000000000000000000000000000003259 208.0
TLS2_k127_6836071_33 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000008947 208.0
TLS2_k127_6836071_34 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000001227 188.0
TLS2_k127_6836071_35 protein conserved in bacteria K13485 - 4.1.1.97 0.0000000000000000000000000000000000000000000000004673 183.0
TLS2_k127_6836071_36 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000008527 185.0
TLS2_k127_6836071_37 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000002716 172.0
TLS2_k127_6836071_38 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.000000000000000000000000000000000000000008321 167.0
TLS2_k127_6836071_39 aerobic-type carbon monoxide dehydrogenase, small subunit CoxS - - - 0.0000000000000000000000000000000000000002822 166.0
TLS2_k127_6836071_4 Flotillin - - - 2.326e-210 683.0
TLS2_k127_6836071_40 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.000000000000000000000000000000000000000559 159.0
TLS2_k127_6836071_41 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000004209 141.0
TLS2_k127_6836071_5 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 616.0
TLS2_k127_6836071_6 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 586.0
TLS2_k127_6836071_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 562.0
TLS2_k127_6836071_8 Polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 546.0
TLS2_k127_6836071_9 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005543 543.0
TLS2_k127_6850593_0 HELICc2 K03722 - 3.6.4.12 0.0 1025.0
TLS2_k127_6850593_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 3.375e-262 829.0
TLS2_k127_6850593_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 475.0
TLS2_k127_6850593_11 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 GO:0000271,GO:0003674,GO:0003824,GO:0004475,GO:0005975,GO:0005976,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008905,GO:0008928,GO:0009058,GO:0009059,GO:0009242,GO:0009628,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0050896,GO:0070568,GO:0071704,GO:1901135,GO:1901137,GO:1901576 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 468.0
TLS2_k127_6850593_12 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 455.0
TLS2_k127_6850593_13 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 466.0
TLS2_k127_6850593_14 cystathionine beta-lyase K01760 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 444.0
TLS2_k127_6850593_15 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 430.0
TLS2_k127_6850593_16 COG0765 ABC-type amino acid transport system, permease component K09971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 432.0
TLS2_k127_6850593_17 L-proline glycine betaine ABC transport system permease protein ProW K02001,K02002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 419.0
TLS2_k127_6850593_18 acid transport K09972 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 411.0
TLS2_k127_6850593_19 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005256 411.0
TLS2_k127_6850593_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 9.088e-234 735.0
TLS2_k127_6850593_20 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 405.0
TLS2_k127_6850593_21 acid transport system permease K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 394.0
TLS2_k127_6850593_22 Protein conserved in bacteria K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005892 397.0
TLS2_k127_6850593_23 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 380.0
TLS2_k127_6850593_24 abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 353.0
TLS2_k127_6850593_25 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 359.0
TLS2_k127_6850593_26 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 327.0
TLS2_k127_6850593_27 Glycine betaine K02000 - 3.6.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 318.0
TLS2_k127_6850593_28 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 301.0
TLS2_k127_6850593_29 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 297.0
TLS2_k127_6850593_3 Aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 1.216e-231 725.0
TLS2_k127_6850593_30 COG4176 ABC-type proline glycine betaine transport system, permease component K02001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002162 285.0
TLS2_k127_6850593_31 Nitrile hydratase K01721,K20807 - 4.2.1.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001789 287.0
TLS2_k127_6850593_32 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000822 278.0
TLS2_k127_6850593_33 Nitrile hydratase K01721,K20807 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000007998 263.0
TLS2_k127_6850593_34 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001456 252.0
TLS2_k127_6850593_35 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000001261 249.0
TLS2_k127_6850593_36 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000007 229.0
TLS2_k127_6850593_37 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000001822 210.0
TLS2_k127_6850593_38 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000002438 186.0
TLS2_k127_6850593_39 23S rRNA-intervening sequence protein - - - 0.000000000000000000000000000000000000000000000002059 179.0
TLS2_k127_6850593_4 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 591.0
TLS2_k127_6850593_40 OsmC-like protein - - - 0.00000000000000000000000000000000000000000007109 165.0
TLS2_k127_6850593_41 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000006847 154.0
TLS2_k127_6850593_42 'TIGRFAM RNA polymerase sigma factor, sigma-70 family' K03088 - - 0.00000000000000000000000000000000000000256 160.0
TLS2_k127_6850593_43 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000311 150.0
TLS2_k127_6850593_44 - - - - 0.000000000000000000000000000000006681 135.0
TLS2_k127_6850593_45 ETC complex I subunit conserved region - - - 0.0000000000000000000000000000002815 126.0
TLS2_k127_6850593_46 SET domain K07117 - - 0.000000000000000000000000000005115 123.0
TLS2_k127_6850593_47 NIPSNAP - - - 0.000000000000000000000000000007953 123.0
TLS2_k127_6850593_48 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000000000000000000000007617 123.0
TLS2_k127_6850593_49 transcriptional regulator - - - 0.0000000000000000000000001147 114.0
TLS2_k127_6850593_5 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 564.0
TLS2_k127_6850593_50 Serine aminopeptidase, S33 - - - 0.0000000000000000000000001452 118.0
TLS2_k127_6850593_51 Protein of unknown function (DUF1499) - - - 0.00000000000000000000001523 112.0
TLS2_k127_6850593_52 PIN domain K07064 - - 0.0000000000000000002056 93.0
TLS2_k127_6850593_53 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.000000000000000000417 91.0
TLS2_k127_6850593_54 Protein of unknown function (DUF1192) - - - 0.000000000005084 68.0
TLS2_k127_6850593_55 23S rRNA-intervening sequence protein - - - 0.00000000001041 72.0
TLS2_k127_6850593_56 SMART RNA-processing protein HAT helix repeating-containing protein - - - 0.000000002592 67.0
TLS2_k127_6850593_57 Protein of unknown function (DUF1501) - - - 0.00000004247 56.0
TLS2_k127_6850593_58 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000711 58.0
TLS2_k127_6850593_59 PFAM Entericidin EcnAB - - - 0.00001003 51.0
TLS2_k127_6850593_6 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 539.0
TLS2_k127_6850593_60 Lysozyme inhibitor LprI - - - 0.0000302 55.0
TLS2_k127_6850593_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 540.0
TLS2_k127_6850593_8 Belongs to the DEAD box helicase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005813 527.0
TLS2_k127_6850593_9 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 491.0
TLS2_k127_6890023_0 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 535.0
TLS2_k127_6890023_1 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 506.0
TLS2_k127_6890023_10 - - - - 0.00003313 52.0
TLS2_k127_6890023_2 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 454.0
TLS2_k127_6890023_3 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005061 284.0
TLS2_k127_6890023_4 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000000000000000000000000000001152 208.0
TLS2_k127_6890023_5 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000004397 209.0
TLS2_k127_6890023_6 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000000000000000000000000000002519 202.0
TLS2_k127_6890023_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000003523 194.0
TLS2_k127_6890023_8 - - - - 0.0000000000002886 75.0
TLS2_k127_6890023_9 BTB/POZ domain - GO:0000151,GO:0000375,GO:0000377,GO:0000387,GO:0000398,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005681,GO:0005737,GO:0006139,GO:0006396,GO:0006397,GO:0006508,GO:0006511,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0010498,GO:0016043,GO:0016070,GO:0016071,GO:0019005,GO:0019222,GO:0019538,GO:0019899,GO:0019941,GO:0022607,GO:0022613,GO:0022618,GO:0030162,GO:0030163,GO:0031461,GO:0031625,GO:0032991,GO:0034622,GO:0034641,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043632,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0050789,GO:0051171,GO:0051246,GO:0051603,GO:0060255,GO:0065003,GO:0065007,GO:0071013,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1990234,GO:1990904 - 0.00000005433 63.0
TLS2_k127_689275_0 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 9.219e-272 850.0
TLS2_k127_689275_1 ABC transporter transmembrane region K02021 - - 3.011e-255 834.0
TLS2_k127_689275_10 - - - - 0.00000000000000000000000006777 119.0
TLS2_k127_689275_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 9.559e-208 665.0
TLS2_k127_689275_3 Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 557.0
TLS2_k127_689275_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 503.0
TLS2_k127_689275_5 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 334.0
TLS2_k127_689275_6 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 319.0
TLS2_k127_689275_7 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006413 305.0
TLS2_k127_689275_8 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000005805 224.0
TLS2_k127_689275_9 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000001759 179.0
TLS2_k127_6912589_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 1.091e-206 662.0
TLS2_k127_6912589_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 387.0
TLS2_k127_6912589_10 histidine kinase A domain protein - - - 0.0000000000000000000006066 102.0
TLS2_k127_6912589_11 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000005264 89.0
TLS2_k127_6912589_2 Reductase C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 362.0
TLS2_k127_6912589_3 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004425,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001466 289.0
TLS2_k127_6912589_4 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004798 259.0
TLS2_k127_6912589_5 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.00000000000000000000000000000000000000000000000000008472 208.0
TLS2_k127_6912589_6 tetR family - - - 0.0000000000000000000000000000000000000000000000000001799 192.0
TLS2_k127_6912589_7 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000006752 165.0
TLS2_k127_6912589_8 PFAM thioesterase superfamily protein - - - 0.0000000000000000000000000001337 130.0
TLS2_k127_6912589_9 cheY-homologous receiver domain - - - 0.0000000000000000000003049 105.0
TLS2_k127_6919346_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 467.0
TLS2_k127_6919346_1 nitrilase K01501,K01502 - 3.5.5.1,3.5.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 426.0
TLS2_k127_6919346_2 AraC-binding-like domain - - - 0.000000000000000000000000000000000000000000000009087 186.0
TLS2_k127_6953002_0 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 466.0
TLS2_k127_6953002_1 NAD(P)H-binding K00023 - 1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 392.0
TLS2_k127_6953002_2 Beta-ketoacyl synthase, N-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009988 312.0
TLS2_k127_6953002_3 Bacterial protein of unknown function (DUF898) - - - 0.000000000000000000000000000000000000000000000000000002641 207.0
TLS2_k127_6953002_4 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000983 203.0
TLS2_k127_6953002_5 PFAM regulatory protein TetR - - - 0.00000000000000000000000000000000000000004763 158.0
TLS2_k127_6953002_6 FabA-like domain K02372 - 4.2.1.59 0.000000000000000000000000000000000000009664 150.0
TLS2_k127_6953002_7 Phosphopantetheine attachment site - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000007099 132.0
TLS2_k127_6953002_8 Predicted membrane protein (DUF2306) - - - 0.0000000000000000000009015 100.0
TLS2_k127_7060836_0 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 407.0
TLS2_k127_7060836_1 transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 326.0
TLS2_k127_7060836_2 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 315.0
TLS2_k127_7060836_3 - - - - 0.000000000000000228 85.0
TLS2_k127_7060836_4 Belongs to the ompA family K03286 - - 0.000000000000002189 89.0
TLS2_k127_7085861_0 Dienelactone hydrolase family K01061 - 3.1.1.45 2.955e-195 616.0
TLS2_k127_7085861_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 541.0
TLS2_k127_7085861_10 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 303.0
TLS2_k127_7085861_11 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002996 252.0
TLS2_k127_7085861_12 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000005703 251.0
TLS2_k127_7085861_13 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001608 238.0
TLS2_k127_7085861_14 AMP-binding enzyme C-terminal domain K02363 - 2.7.7.58,6.3.2.14 0.0000000000000000000000000000000000000000000000000000000001469 211.0
TLS2_k127_7085861_15 glyoxalase K08234 - - 0.0000000000000000000000000000000000000000000000000000000001681 218.0
TLS2_k127_7085861_16 - - - - 0.00000000000000000000000000000000000000000000000000001154 194.0
TLS2_k127_7085861_17 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000832 192.0
TLS2_k127_7085861_18 FCD K11475 - - 0.000000000000000000000000000000000000000000000004194 181.0
TLS2_k127_7085861_19 Cupin domain - - - 0.0000000000000000000000000000000000000000000007814 177.0
TLS2_k127_7085861_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 493.0
TLS2_k127_7085861_20 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000005022 162.0
TLS2_k127_7085861_21 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000008597 156.0
TLS2_k127_7085861_22 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000006284 72.0
TLS2_k127_7085861_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 487.0
TLS2_k127_7085861_4 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 411.0
TLS2_k127_7085861_5 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 428.0
TLS2_k127_7085861_6 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 370.0
TLS2_k127_7085861_7 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 312.0
TLS2_k127_7085861_8 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 308.0
TLS2_k127_7085861_9 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 310.0
TLS2_k127_7175466_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.133e-209 666.0
TLS2_k127_7175466_1 signal transduction histidine kinase K13587 - 2.7.13.3 2.039e-197 645.0
TLS2_k127_7175466_10 COG1716 FOG FHA domain - - - 0.0000000000000000000000000000001221 135.0
TLS2_k127_7175466_11 Trypsin - - - 0.0000000000000000000000003159 120.0
TLS2_k127_7175466_12 Trypsin - - - 0.00000000000000000000001673 115.0
TLS2_k127_7175466_13 Trypsin-like peptidase domain - - - 0.00000000000000000007238 104.0
TLS2_k127_7175466_14 Trypsin - - - 0.0000000000000000004184 102.0
TLS2_k127_7175466_15 Evidence 4 Homologs of previously reported genes of - - - 0.0000000007128 72.0
TLS2_k127_7175466_16 Evidence 4 Homologs of previously reported genes of - - - 0.00004722 56.0
TLS2_k127_7175466_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 554.0
TLS2_k127_7175466_3 Amidohydrolase K10220 - 4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 364.0
TLS2_k127_7175466_4 Encapsulating protein for peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 337.0
TLS2_k127_7175466_5 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 312.0
TLS2_k127_7175466_6 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000000000000000000000001806 198.0
TLS2_k127_7175466_7 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000002294 199.0
TLS2_k127_7175466_8 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000007996 196.0
TLS2_k127_7175466_9 Evidence 4 Homologs of previously reported genes of K09700 - - 0.00000000000000000000000000000000000000000008776 164.0
TLS2_k127_7175977_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 2.111e-225 709.0
TLS2_k127_7175977_1 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007461 566.0
TLS2_k127_7175977_2 Acyl-CoA dehydrogenase, C-terminal domain K16047,K20942 - 1.14.14.12,1.14.14.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 417.0
TLS2_k127_7175977_3 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 287.0
TLS2_k127_7175977_4 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003935 247.0
TLS2_k127_7175977_5 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000869 249.0
TLS2_k127_7175977_6 MarR family - - - 0.00000000000000001205 92.0
TLS2_k127_7177362_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.07e-315 981.0
TLS2_k127_7177362_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 1.834e-203 643.0
TLS2_k127_7177362_10 Phosphoglycerate mutase family K08296 - - 0.000000000000000000000000000000000000000004349 162.0
TLS2_k127_7177362_2 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 461.0
TLS2_k127_7177362_3 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006791 382.0
TLS2_k127_7177362_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 289.0
TLS2_k127_7177362_5 NDK K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000002922 225.0
TLS2_k127_7177362_6 Belongs to the DnaA family - - - 0.00000000000000000000000000000000000000000000000000000000001579 215.0
TLS2_k127_7177362_7 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000002445 211.0
TLS2_k127_7177362_8 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.00000000000000000000000000000000000000000000000000704 196.0
TLS2_k127_7177362_9 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.000000000000000000000000000000000000000000005131 178.0
TLS2_k127_7236838_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 2543.0
TLS2_k127_7236838_1 carbamoyl transferase, NodU family K00612 - - 1.029e-308 956.0
TLS2_k127_7236838_10 - - - - 0.0000000000000000000000000000003174 131.0
TLS2_k127_7236838_11 - - - - 0.0000000000000000104 83.0
TLS2_k127_7236838_12 Glycosyltransferase family 87 - - - 0.0000004662 57.0
TLS2_k127_7236838_13 - - - - 0.000001964 61.0
TLS2_k127_7236838_14 Protein of unknown function (DUF1501) - - - 0.00006798 56.0
TLS2_k127_7236838_2 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 2.266e-253 787.0
TLS2_k127_7236838_3 Sodium:sulfate symporter transmembrane region - - - 9.731e-238 751.0
TLS2_k127_7236838_4 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001798 289.0
TLS2_k127_7236838_5 Pfam:DUF2029 K13669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003008 257.0
TLS2_k127_7236838_6 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000009093 172.0
TLS2_k127_7236838_7 PRC-barrel domain - - - 0.000000000000000000000000000000005931 138.0
TLS2_k127_7236838_8 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000007737 142.0
TLS2_k127_7236838_9 Luciferase-like monooxygenase K21731 - 1.14.13.162 0.00000000000000000000000000000001708 141.0
TLS2_k127_7340942_0 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 415.0
TLS2_k127_7340942_1 Abc transporter K05833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006765 287.0
TLS2_k127_7340942_2 PFAM Branched-chain amino acid transport system permease component K05832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003352 252.0
TLS2_k127_7340942_3 PFAM ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000001064 248.0
TLS2_k127_7340942_4 Ring hydroxylating subunit beta family protein 1 - - - 0.0000000000000000000000000000000002394 144.0
TLS2_k127_7340942_5 PFAM Excinuclease ABC, C subunit domain protein K07461 - - 0.000000000000000000000000002373 114.0
TLS2_k127_7340942_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000003628 95.0
TLS2_k127_7352998_0 Major facilitator superfamily - - - 4.938e-215 677.0
TLS2_k127_7352998_1 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 542.0
TLS2_k127_7352998_10 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000008559 148.0
TLS2_k127_7352998_11 GIY-YIG catalytic domain K07461 - - 0.00000000000000000000000000000000018 135.0
TLS2_k127_7352998_12 thioesterase K07107 - - 0.000000000000000000000000000000134 136.0
TLS2_k127_7352998_13 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000002813 128.0
TLS2_k127_7352998_14 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000008058 106.0
TLS2_k127_7352998_15 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000002382 102.0
TLS2_k127_7352998_16 Domain of unknown function (DUF4442) - - - 0.0000000000000000009024 91.0
TLS2_k127_7352998_17 Protein of unknown function (DUF1328) - - - 0.0000000000008209 72.0
TLS2_k127_7352998_18 Tetratricopeptide repeat - - - 0.00000000627 65.0
TLS2_k127_7352998_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 497.0
TLS2_k127_7352998_3 Protein conserved in bacteria K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 388.0
TLS2_k127_7352998_4 Glutathione S-Transferase K07393 - 1.8.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 379.0
TLS2_k127_7352998_5 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 328.0
TLS2_k127_7352998_6 COG0811 Biopolymer transport proteins K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 299.0
TLS2_k127_7352998_7 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000007312 221.0
TLS2_k127_7352998_8 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000000009183 211.0
TLS2_k127_7352998_9 Biopolymer transport protein K03559,K03560 - - 0.000000000000000000000000000000000000000000001953 171.0
TLS2_k127_7360623_0 PFAM Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 586.0
TLS2_k127_7360623_1 Ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 533.0
TLS2_k127_7360623_10 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000000001817 142.0
TLS2_k127_7360623_11 ParE toxin of type II toxin-antitoxin system, parDE K19092 - - 0.000000000000000000004329 96.0
TLS2_k127_7360623_2 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 469.0
TLS2_k127_7360623_3 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 399.0
TLS2_k127_7360623_4 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 387.0
TLS2_k127_7360623_5 Enoyl-CoA hydratase carnithine racemase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006021 289.0
TLS2_k127_7360623_6 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000001024 264.0
TLS2_k127_7360623_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001708 247.0
TLS2_k127_7360623_8 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000000000000000000001419 188.0
TLS2_k127_7360623_9 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000001069 177.0
TLS2_k127_7363598_0 RTCB protein K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 506.0
TLS2_k127_7363598_1 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 492.0
TLS2_k127_7363598_10 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000007012 169.0
TLS2_k127_7363598_11 transcriptional regulator - - - 0.0000000000000000000000000000000000000006032 166.0
TLS2_k127_7363598_12 Transcriptional regulator, AraC family - - - 0.00000000000000000000000000000001969 138.0
TLS2_k127_7363598_13 Belongs to the bacterial histone-like protein family K03530 - - 0.00000000000000000000000000002235 119.0
TLS2_k127_7363598_14 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000000000000000000000001228 119.0
TLS2_k127_7363598_15 Cold shock K03704 - - 0.00000000000000000000000006556 108.0
TLS2_k127_7363598_16 Cold shock K03704 - - 0.0000000000000000000000003298 109.0
TLS2_k127_7363598_17 Tautomerase enzyme K01821 - 5.3.2.6 0.00000000000005015 76.0
TLS2_k127_7363598_19 fatty acid desaturase K00508 - 1.14.19.3 0.0002532 48.0
TLS2_k127_7363598_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 492.0
TLS2_k127_7363598_3 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 398.0
TLS2_k127_7363598_4 PFAM NAD binding domain of 6-phosphogluconate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 323.0
TLS2_k127_7363598_5 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 317.0
TLS2_k127_7363598_6 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001736 268.0
TLS2_k127_7363598_7 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001518 267.0
TLS2_k127_7363598_8 Tellurite resistance protein TehB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001733 258.0
TLS2_k127_7363598_9 Exopolysaccharide synthesis, ExoD - - - 0.0000000000000000000000000000000000000000000000000002155 198.0
TLS2_k127_7369703_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 425.0
TLS2_k127_7369703_1 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 335.0
TLS2_k127_7369703_2 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000001408 215.0
TLS2_k127_7369703_3 Usg-like family - - - 0.000000000000000000000000000000001285 131.0
TLS2_k127_7369703_4 Belongs to the UPF0235 family K09131 - - 0.000000000000000000000000002846 117.0
TLS2_k127_7369703_5 YGGT family K02221 - - 0.0000000000000000002056 93.0
TLS2_k127_7369703_6 TAP-like protein - - - 0.000002287 57.0
TLS2_k127_7373671_0 Sulfite reductase K00381 - 1.8.1.2 1.137e-264 827.0
TLS2_k127_7373671_1 Catalyzes the synthesis of activated sulfate K00955 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 622.0
TLS2_k127_7373671_2 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 414.0
TLS2_k127_7373671_3 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000001272 271.0
TLS2_k127_7373671_4 Protein conserved in bacteria - - - 0.00000000000000000000000000000002309 138.0
TLS2_k127_7374850_0 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 323.0
TLS2_k127_7374850_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004698 281.0
TLS2_k127_7374850_2 ATPases associated with a variety of cellular activities K01995,K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000002041 234.0
TLS2_k127_7374850_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000002291 220.0
TLS2_k127_7376535_0 glycoside hydrolase family 65 central catalytic - - - 0.0 1122.0
TLS2_k127_7376535_1 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 2.689e-195 629.0
TLS2_k127_7376535_10 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008651 269.0
TLS2_k127_7376535_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 591.0
TLS2_k127_7376535_3 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 563.0
TLS2_k127_7376535_4 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 542.0
TLS2_k127_7376535_5 3-hydroxyacyl-coa dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 445.0
TLS2_k127_7376535_6 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 424.0
TLS2_k127_7376535_7 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 387.0
TLS2_k127_7376535_8 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 356.0
TLS2_k127_7376535_9 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001529 284.0
TLS2_k127_7377013_0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 7.202e-292 906.0
TLS2_k127_7377013_1 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 621.0
TLS2_k127_7377013_10 COG1560 Lauroyl myristoyl acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000008465 263.0
TLS2_k127_7377013_11 Protein of unknown function (DUF1194) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001549 241.0
TLS2_k127_7377013_12 Diguanylate cyclase K21084 - 2.7.7.65 0.0000000000000000000000000000000000000000000000003522 198.0
TLS2_k127_7377013_13 Small Multidrug Resistance protein K11741 - - 0.0000000000000000000000000000000000000000002612 162.0
TLS2_k127_7377013_14 Sulphur oxidation protein SoxZ K17227 - - 0.000000000000000000000008988 106.0
TLS2_k127_7377013_15 CsbD-like - - - 0.00000000000000000000001172 108.0
TLS2_k127_7377013_16 Cytochrome c - - - 0.00000000000000000000001486 106.0
TLS2_k127_7377013_17 Sulfur oxidation protein SoxY K17226 - - 0.00000000000000000000005255 115.0
TLS2_k127_7377013_18 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0030266,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.0000000009741 60.0
TLS2_k127_7377013_19 - - - - 0.000224 48.0
TLS2_k127_7377013_2 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 427.0
TLS2_k127_7377013_3 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 396.0
TLS2_k127_7377013_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 356.0
TLS2_k127_7377013_5 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 327.0
TLS2_k127_7377013_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 322.0
TLS2_k127_7377013_7 (LPS) heptosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 303.0
TLS2_k127_7377013_8 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 297.0
TLS2_k127_7377013_9 transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 314.0
TLS2_k127_7381381_0 sulfate ABC transporter K02048 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008152,GO:0008272,GO:0009987,GO:0015698,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0043199,GO:0044237,GO:0044464,GO:0051179,GO:0051234,GO:0072348,GO:1901681 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 465.0
TLS2_k127_7381381_1 TIGRFAM sulfate ABC transporter, permease protein CysW, sulfate ABC transporter, permease protein K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 409.0
TLS2_k127_7381381_2 Sulfate ABC transporter inner membrane subunit CysT K02046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 380.0
TLS2_k127_7381381_3 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005236 376.0
TLS2_k127_7411853_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 8.588e-258 830.0
TLS2_k127_7411853_1 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 546.0
TLS2_k127_7411853_2 conserved protein (DUF2260) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 331.0
TLS2_k127_7411853_3 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 314.0
TLS2_k127_7411853_4 Inhibitor of apoptosis-promoting Bax1 K06890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000851 277.0
TLS2_k127_7411853_5 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000834 161.0
TLS2_k127_7411853_6 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000003824 100.0
TLS2_k127_7418299_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 2.5e-323 1022.0
TLS2_k127_7418299_1 Belongs to the thiolase family K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 525.0
TLS2_k127_7418299_2 Pfam:Pyridox_oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000005131 234.0
TLS2_k127_7418299_3 PFAM Taurine catabolism dioxygenase TauD TfdA - - - 0.0000000000000000000000000000000000000000000000003979 190.0
TLS2_k127_7418299_4 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000564 165.0
TLS2_k127_7418299_5 SnoaL-like domain - - - 0.000000000000000000000000000000000000009025 151.0
TLS2_k127_7454872_0 AMP-binding enzyme C-terminal domain - - - 5.268e-221 696.0
TLS2_k127_7454872_1 Carbon-nitrogen hydrolase K01502 - 3.5.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 418.0
TLS2_k127_7454872_2 AMP-binding enzyme C-terminal domain K00666,K16876 - 6.2.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000008464 257.0
TLS2_k127_7454872_3 Putative transposase of IS4/5 family (DUF4096) K07492 - - 0.00006371 46.0
TLS2_k127_7458780_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1225.0
TLS2_k127_7458780_1 Glycine cleavage system T protein K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 446.0
TLS2_k127_7458780_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000004172 159.0
TLS2_k127_7458780_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000009573 162.0
TLS2_k127_7458780_4 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000000000000000000707 141.0
TLS2_k127_7458780_5 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000001452 131.0
TLS2_k127_7458780_6 Iron-binding zinc finger CDGSH type - - - 0.000000000000000000000000001421 115.0
TLS2_k127_7458780_7 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000001082 98.0
TLS2_k127_7458780_8 - - - - 0.00000000000000001663 92.0
TLS2_k127_7458780_9 Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000000106 95.0
TLS2_k127_7463245_0 PFAM AMP-dependent synthetase and ligase K01895,K08295 - 6.2.1.1,6.2.1.32 8.78e-215 680.0
TLS2_k127_7463245_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007283 304.0
TLS2_k127_7463245_2 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000000000001641 165.0
TLS2_k127_765576_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 532.0
TLS2_k127_765576_1 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000000005432 179.0
TLS2_k127_765576_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000003081 168.0
TLS2_k127_765576_3 - - - - 0.00000000000005671 79.0
TLS2_k127_765576_4 - - - - 0.0000000002981 64.0
TLS2_k127_767621_0 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 388.0
TLS2_k127_767621_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000002226 267.0
TLS2_k127_767621_2 Ribosomal protein L11 methyltransferase (PrmA) - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736 - 0.0000000000000000000000000000000000000000000000000000000000000000001238 251.0
TLS2_k127_767621_3 Heat shock protein HtpX K03799 - - 0.000000000000000000000000000000000000000000000000000000000000001598 231.0
TLS2_k127_767621_4 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.00000000000000000001199 91.0
TLS2_k127_767621_5 Glycosyltransferase like family 2 - - - 0.000000000000001715 83.0
TLS2_k127_767621_6 PIN domain - - - 0.00000000002079 68.0
TLS2_k127_777094_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182,K16874 - 4.1.1.98 1.106e-263 825.0
TLS2_k127_777094_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 9.2e-257 801.0
TLS2_k127_777094_2 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 425.0
TLS2_k127_777094_3 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 384.0
TLS2_k127_777094_4 Bacterial extracellular solute-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 370.0
TLS2_k127_777094_5 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 364.0
TLS2_k127_777094_6 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 329.0
TLS2_k127_777094_7 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001363 284.0
TLS2_k127_777094_8 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000002132 137.0
TLS2_k127_800634_0 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 512.0
TLS2_k127_800634_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 389.0
TLS2_k127_800634_2 Predicted permease YjgP/YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 359.0
TLS2_k127_800634_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 325.0
TLS2_k127_800634_4 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008956 282.0
TLS2_k127_800634_5 Chaperone SurA K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000003538 236.0
TLS2_k127_803669_0 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 425.0
TLS2_k127_803669_1 Protein of unknown function (DUF1013) K09987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000029 249.0
TLS2_k127_803669_2 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000001891 129.0
TLS2_k127_80924_0 proline dipeptidase activity K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009469 303.0
TLS2_k127_80924_1 ABC-type nitrate sulfonate bicarbonate transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001419 284.0
TLS2_k127_80924_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002008 272.0
TLS2_k127_80924_3 lactoylglutathione lyase activity K11210 - - 0.0000000000000000000000000000000000000000000009207 171.0
TLS2_k127_80924_4 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000002532 107.0
TLS2_k127_811900_0 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 504.0
TLS2_k127_811900_1 Protein of unknown function (DUF2889) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000935 236.0
TLS2_k127_811900_2 Cupin domain K00450 - 1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000000001481 227.0
TLS2_k127_811900_3 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000000000000001725 177.0
TLS2_k127_811900_4 Molecular chaperone - - - 0.00000000000000000000000000000000000013 149.0
TLS2_k127_811900_5 BolA-like protein K05527,K22066 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.00000000000000000000000000001801 120.0
TLS2_k127_811900_6 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0004605 52.0
TLS2_k127_82396_0 peptidase U62, modulator of DNA gyrase K03568 - - 2.588e-222 698.0
TLS2_k127_82396_1 Penicillin amidase K01434 - 3.5.1.11 4.615e-218 701.0
TLS2_k127_82396_10 Enoyl-CoA hydratase K13816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003928 259.0
TLS2_k127_82396_11 PFAM O-methyltransferase, family 3 K00588 - 2.1.1.104 0.000000000000000000000000000000000000000000000000000000000000009997 223.0
TLS2_k127_82396_12 transduction histidine kinase K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000007839 224.0
TLS2_k127_82396_13 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000006576 170.0
TLS2_k127_82396_14 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000103 171.0
TLS2_k127_82396_15 - - - - 0.00000000000000000000000000000000000000001292 170.0
TLS2_k127_82396_16 Glutathione S-transferase - - - 0.000000000000000000000000000000000000001137 155.0
TLS2_k127_82396_17 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000001411 150.0
TLS2_k127_82396_18 phosphohistidine phosphatase, SixA - - - 0.00000000000000000000000000000000002082 144.0
TLS2_k127_82396_19 - - - - 0.00000000000000000000000002625 117.0
TLS2_k127_82396_2 glutamate--cysteine ligase K01919 - 6.3.2.2 4.553e-214 673.0
TLS2_k127_82396_20 gag-polyprotein putative aspartyl protease K06985 - - 0.0000000000000000000000008668 115.0
TLS2_k127_82396_21 transcriptional regulators K22042 - - 0.000000000000000000000001089 118.0
TLS2_k127_82396_22 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000000000002504 102.0
TLS2_k127_82396_23 CsbD-like - - - 0.0000000000000000002814 88.0
TLS2_k127_82396_3 Sulfate transporter antisigma-factor antagonist STAS K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 575.0
TLS2_k127_82396_4 His Kinase A (phosphoacceptor) domain K10715 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 495.0
TLS2_k127_82396_5 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007332 418.0
TLS2_k127_82396_6 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 409.0
TLS2_k127_82396_7 Adenylate cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 379.0
TLS2_k127_82396_8 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 327.0
TLS2_k127_82396_9 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005514 265.0
TLS2_k127_853531_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 584.0
TLS2_k127_853531_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 527.0
TLS2_k127_853531_10 Domain of unknown function (DUF3291) - - - 0.0000000000000000000000000000000000000000000000000000000007069 205.0
TLS2_k127_853531_11 transcriptional - - - 0.0000000000000000000000000000000000000000000000000004141 193.0
TLS2_k127_853531_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 355.0
TLS2_k127_853531_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 347.0
TLS2_k127_853531_4 Male sterility protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 322.0
TLS2_k127_853531_5 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 286.0
TLS2_k127_853531_6 Endonuclease exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 293.0
TLS2_k127_853531_7 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001888 265.0
TLS2_k127_853531_8 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001156 243.0
TLS2_k127_853531_9 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001717 244.0
TLS2_k127_85635_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596 - 4.1.1.64 3.138e-221 693.0
TLS2_k127_85635_1 Glutathione S-transferase, C-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 417.0
TLS2_k127_85635_10 Domain of unknown function (DUF4189) - - - 0.00000000004085 70.0
TLS2_k127_85635_11 - - - - 0.00000001923 62.0
TLS2_k127_85635_2 DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 339.0
TLS2_k127_85635_3 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008151 267.0
TLS2_k127_85635_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001636 263.0
TLS2_k127_85635_5 Activator of Hsp90 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001801 251.0
TLS2_k127_85635_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000004717 223.0
TLS2_k127_85635_7 Stringent starvation protein B K09985 - - 0.0000000000000000000000000000000000000005508 156.0
TLS2_k127_85635_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000001315 150.0
TLS2_k127_85635_9 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000001576 126.0
TLS2_k127_886791_0 Aconitase family (aconitate hydratase) K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 544.0
TLS2_k127_886791_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008035 515.0
TLS2_k127_886791_2 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 329.0
TLS2_k127_886791_3 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001833 252.0
TLS2_k127_886791_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000008506 200.0
TLS2_k127_886791_5 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000008483 166.0
TLS2_k127_897666_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 2.479e-233 732.0
TLS2_k127_897666_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001209 276.0
TLS2_k127_897666_2 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002464 273.0
TLS2_k127_897666_3 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007709 244.0
TLS2_k127_897666_4 protein kinase activity - - - 0.00000000000000000000000000000002697 136.0
TLS2_k127_953999_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1548.0
TLS2_k127_953999_1 PFAM NADH Ubiquinone plastoquinone (complex I) K12141 - - 4.236e-236 750.0
TLS2_k127_953999_10 PRC-barrel domain - - - 0.000000000000000000000000000000000000000003569 162.0
TLS2_k127_953999_11 EthD domain - - - 0.0000000000000000000000000000000004027 133.0
TLS2_k127_953999_12 Ring hydroxylating subunit beta family protein 1 - - - 0.0000000000000000000000000000000005359 147.0
TLS2_k127_953999_13 Domain of unknown function (DUF1989) K09967 - - 0.000000000000000000000000102 121.0
TLS2_k127_953999_14 Protein of unknown function (DUF3309) - - - 0.000000000000005406 80.0
TLS2_k127_953999_15 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000001901 81.0
TLS2_k127_953999_16 Domain of unknown function (DUF4189) - - - 0.000000001739 63.0
TLS2_k127_953999_2 NADH-ubiquinone oxidoreductase chain 49kDa - - - 1.398e-218 692.0
TLS2_k127_953999_3 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 548.0
TLS2_k127_953999_4 Rieske 2Fe-2S domain protein K14748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 447.0
TLS2_k127_953999_5 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 352.0
TLS2_k127_953999_6 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 304.0
TLS2_k127_953999_7 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 299.0
TLS2_k127_953999_8 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003637 283.0
TLS2_k127_953999_9 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005453 269.0
TLS2_k127_961768_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01908 - 6.2.1.17 4.815e-199 625.0
TLS2_k127_961768_1 Nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 373.0
TLS2_k127_961768_2 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008708 294.0
TLS2_k127_967018_0 4Fe-4S dicluster domain - - - 0.0 1389.0
TLS2_k127_967018_1 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 1.485e-297 955.0
TLS2_k127_967018_10 Major facilitator superfamily K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 429.0
TLS2_k127_967018_11 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 412.0
TLS2_k127_967018_12 Iron-containing alcohol dehydrogenase K13954,K19954 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000546 403.0
TLS2_k127_967018_13 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007684 406.0
TLS2_k127_967018_14 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 367.0
TLS2_k127_967018_15 Ornithine cyclodeaminase/mu-crystallin family K01750,K19743 - 1.5.1.1,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006953 371.0
TLS2_k127_967018_16 Bacterial periplasmic substrate-binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 343.0
TLS2_k127_967018_17 Sarcosine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 349.0
TLS2_k127_967018_18 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 325.0
TLS2_k127_967018_19 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001287 309.0
TLS2_k127_967018_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 4.748e-277 876.0
TLS2_k127_967018_20 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000473 278.0
TLS2_k127_967018_21 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003435 270.0
TLS2_k127_967018_22 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001393 266.0
TLS2_k127_967018_23 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000002743 250.0
TLS2_k127_967018_24 Acyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001377 242.0
TLS2_k127_967018_25 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000009946 179.0
TLS2_k127_967018_26 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.0000000000000000000000000000000000000000000001965 175.0
TLS2_k127_967018_27 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000002402 170.0
TLS2_k127_967018_28 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000000000000000003532 148.0
TLS2_k127_967018_29 SMART PDZ DHR GLGF domain protein - - - 0.00000000000000000000000000000000001222 151.0
TLS2_k127_967018_3 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 596.0
TLS2_k127_967018_30 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000003263 138.0
TLS2_k127_967018_32 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000008248 142.0
TLS2_k127_967018_33 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.000000000000000000000000000009084 122.0
TLS2_k127_967018_34 Protein of unknown function (FYDLN_acid) - - - 0.0000000000262 71.0
TLS2_k127_967018_35 Lipopolysaccharide assembly protein A domain - - - 0.00000002811 63.0
TLS2_k127_967018_36 - - - - 0.0003507 45.0
TLS2_k127_967018_4 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 579.0
TLS2_k127_967018_5 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 535.0
TLS2_k127_967018_6 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 531.0
TLS2_k127_967018_7 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 484.0
TLS2_k127_967018_8 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 436.0
TLS2_k127_967018_9 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 435.0
TLS2_k127_99935_0 Major Facilitator Superfamily K02575 - - 1.258e-215 677.0
TLS2_k127_99935_1 Major Facilitator Superfamily K02575 - - 7.467e-209 675.0
TLS2_k127_99935_2 PFAM HI0933 family protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 492.0
TLS2_k127_99935_3 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain K04940 - 1.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 475.0
TLS2_k127_99935_4 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 334.0
TLS2_k127_99935_5 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000001032 243.0
TLS2_k127_99935_6 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K13642 - - 0.00000000000000000000000000000000000000000000000003444 188.0
TLS2_k127_99935_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000001387 111.0
TLS2_k127_99935_8 pyridine nucleotide-disulphide oxidoreductase - GO:0003674,GO:0003824,GO:0005575,GO:0006082,GO:0006629,GO:0006790,GO:0008146,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016782,GO:0031224,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044272,GO:0044281,GO:0044425,GO:0046505,GO:0046506,GO:0071704,GO:1901576 - 0.0000000000124 73.0