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Overview

ID MAG04025
Name TLS2_bin.68
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Actinomycetota
Class Acidimicrobiia
Order UBA5794
Family ZC4RG35
Genus ZC4RG35
Species
Assembly information
Completeness (%) 92.87
Contamination (%) 0.79
GC content (%) 65.0
N50 (bp) 39,661
Genome size (bp) 2,502,042

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2315

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1151799_0 Heavy metal translocating P-type atpase K17686 - 3.6.3.54 1.911e-291 918.0
TLS2_k127_1151799_1 PFAM carbohydrate kinase K00854 - 2.7.1.17 1.73e-207 655.0
TLS2_k127_1151799_10 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 336.0
TLS2_k127_1151799_11 PFAM Integral membrane protein TerC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005287 323.0
TLS2_k127_1151799_12 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 291.0
TLS2_k127_1151799_13 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002905 280.0
TLS2_k127_1151799_14 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000411 272.0
TLS2_k127_1151799_15 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000942 282.0
TLS2_k127_1151799_16 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000025 231.0
TLS2_k127_1151799_17 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000003525 220.0
TLS2_k127_1151799_18 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000007065 205.0
TLS2_k127_1151799_19 PFAM OsmC family protein - - - 0.00000000000000000000000000000000000000000000000000000004488 205.0
TLS2_k127_1151799_2 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 596.0
TLS2_k127_1151799_20 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000002224 189.0
TLS2_k127_1151799_21 UPF0060 membrane protein K09771 - - 0.000000000000000000000000000000000000000000000000003071 187.0
TLS2_k127_1151799_22 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K00082,K11752,K14654 - 1.1.1.193,1.1.1.302,3.5.4.26 0.0000000000000000000000000000000000000000000000007751 183.0
TLS2_k127_1151799_23 nitrogen regulatory protein P-II K04751 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000003865 160.0
TLS2_k127_1151799_24 - - - - 0.0000000000000000000000000000000000001154 146.0
TLS2_k127_1151799_25 transcriptional regulator K19591 - - 0.000000000000000000000000000000000006783 141.0
TLS2_k127_1151799_26 Cupredoxin-like domain - - - 0.00000000000000000000000000000002338 138.0
TLS2_k127_1151799_27 SnoaL-like domain - - - 0.0000000000000000000000003879 109.0
TLS2_k127_1151799_28 Rho termination factor, N-terminal domain - - - 0.000000000000000000000001388 107.0
TLS2_k127_1151799_29 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000007189 117.0
TLS2_k127_1151799_3 glutamate symporter K03312 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 500.0
TLS2_k127_1151799_30 PhoQ Sensor K03320,K20974 - 2.7.13.3 0.000000000000000000001582 109.0
TLS2_k127_1151799_31 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000461 94.0
TLS2_k127_1151799_32 Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region K21600 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010272,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097077,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000001822 86.0
TLS2_k127_1151799_33 - - - - 0.00000000000000004411 89.0
TLS2_k127_1151799_35 Short C-terminal domain K08982 - - 0.000000001235 61.0
TLS2_k127_1151799_36 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00000008293 64.0
TLS2_k127_1151799_37 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.00000008327 61.0
TLS2_k127_1151799_38 amidohydrolase - - - 0.0000001217 55.0
TLS2_k127_1151799_4 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 468.0
TLS2_k127_1151799_40 amidohydrolase - - - 0.0005062 51.0
TLS2_k127_1151799_5 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 440.0
TLS2_k127_1151799_6 Ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 445.0
TLS2_k127_1151799_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 393.0
TLS2_k127_1151799_8 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 374.0
TLS2_k127_1151799_9 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 364.0
TLS2_k127_1289510_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 2798.0
TLS2_k127_1289510_1 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 3.051e-277 870.0
TLS2_k127_1289510_10 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 324.0
TLS2_k127_1289510_11 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000523 312.0
TLS2_k127_1289510_12 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001262 257.0
TLS2_k127_1289510_13 ABC transporter K02017,K02018 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000001487 254.0
TLS2_k127_1289510_14 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000007306 235.0
TLS2_k127_1289510_15 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000003203 229.0
TLS2_k127_1289510_16 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000001378 239.0
TLS2_k127_1289510_17 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000372 233.0
TLS2_k127_1289510_18 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000009072 209.0
TLS2_k127_1289510_19 PIN domain - - - 0.000000000000000000000000000000000000000000000000001076 185.0
TLS2_k127_1289510_2 Hemerythrin HHE cation binding domain K01534 - 3.6.3.3,3.6.3.5 2.64e-221 709.0
TLS2_k127_1289510_20 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000001358 178.0
TLS2_k127_1289510_21 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000002257 150.0
TLS2_k127_1289510_22 Cytochrome c - - - 0.000000000000000000000000000000002243 143.0
TLS2_k127_1289510_23 COGs COG3593 ATP-dependent endonuclease of the OLD family K07459 - - 0.0000000000000000000000000000006503 137.0
TLS2_k127_1289510_24 glyoxalase III activity - - - 0.000000000000000000000000000002722 124.0
TLS2_k127_1289510_25 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000002911 121.0
TLS2_k127_1289510_26 MerR family regulatory protein - - - 0.0000000000000000000000005746 110.0
TLS2_k127_1289510_27 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000001622 106.0
TLS2_k127_1289510_28 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000004297 91.0
TLS2_k127_1289510_29 Activator of Hsp90 ATPase - - - 0.00000000000001304 79.0
TLS2_k127_1289510_3 Class II release factor RF3, C-terminal domain K02837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008925 598.0
TLS2_k127_1289510_30 peptidase U32 K08303 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000001533 76.0
TLS2_k127_1289510_31 SnoaL-like polyketide cyclase K06893 - - 0.00000000000006306 76.0
TLS2_k127_1289510_32 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000002502 71.0
TLS2_k127_1289510_33 Protein of unknown function (DUF2795) - - - 0.00000002064 58.0
TLS2_k127_1289510_34 Cupin 2, conserved barrel domain protein - - - 0.0001483 48.0
TLS2_k127_1289510_35 Helix-turn-helix domain K07729 - - 0.0001529 53.0
TLS2_k127_1289510_4 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 476.0
TLS2_k127_1289510_5 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 453.0
TLS2_k127_1289510_6 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 406.0
TLS2_k127_1289510_7 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 381.0
TLS2_k127_1289510_8 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 366.0
TLS2_k127_1289510_9 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 347.0
TLS2_k127_1334169_0 Flavin containing amine oxidoreductase - - - 2.973e-250 781.0
TLS2_k127_1334169_1 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 4.35e-217 686.0
TLS2_k127_1334169_10 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 410.0
TLS2_k127_1334169_11 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007164 402.0
TLS2_k127_1334169_12 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 391.0
TLS2_k127_1334169_13 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 392.0
TLS2_k127_1334169_14 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 371.0
TLS2_k127_1334169_15 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 368.0
TLS2_k127_1334169_16 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 353.0
TLS2_k127_1334169_17 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 342.0
TLS2_k127_1334169_18 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 346.0
TLS2_k127_1334169_19 COG1177 ABC-type spermidine putrescine transport system, permease component II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 340.0
TLS2_k127_1334169_2 belongs to the aldehyde dehydrogenase family K21802 - 1.2.1.67 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 564.0
TLS2_k127_1334169_20 Putrescine transport system permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 319.0
TLS2_k127_1334169_21 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009748 327.0
TLS2_k127_1334169_22 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 302.0
TLS2_k127_1334169_23 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008149 291.0
TLS2_k127_1334169_24 Transcriptional regulator K02624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000913 285.0
TLS2_k127_1334169_25 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004913 297.0
TLS2_k127_1334169_26 protocatechuate 3,4-dioxygenase K00449 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002919 280.0
TLS2_k127_1334169_27 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002563 271.0
TLS2_k127_1334169_28 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009273 253.0
TLS2_k127_1334169_29 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000001955 250.0
TLS2_k127_1334169_3 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007209 561.0
TLS2_k127_1334169_30 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008717 244.0
TLS2_k127_1334169_31 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000188 234.0
TLS2_k127_1334169_32 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756,K01857 - 4.3.2.2,5.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000003003 244.0
TLS2_k127_1334169_33 pfam abc K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000003346 230.0
TLS2_k127_1334169_34 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000004215 224.0
TLS2_k127_1334169_35 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000009787 225.0
TLS2_k127_1334169_36 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000008283 236.0
TLS2_k127_1334169_37 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000004325 218.0
TLS2_k127_1334169_38 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000004621 229.0
TLS2_k127_1334169_39 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000007596 212.0
TLS2_k127_1334169_4 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 538.0
TLS2_k127_1334169_40 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000003084 202.0
TLS2_k127_1334169_41 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000388 211.0
TLS2_k127_1334169_42 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000001144 201.0
TLS2_k127_1334169_43 protocatechuate 3,4-dioxygenase K00448 - 1.13.11.3 0.00000000000000000000000000000000000000000001849 175.0
TLS2_k127_1334169_44 decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000001964 163.0
TLS2_k127_1334169_45 MafB19-like deaminase - - - 0.0000000000000000000000000000000000000000002152 159.0
TLS2_k127_1334169_46 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000004306 158.0
TLS2_k127_1334169_47 branched-chain amino acid transport system, permease component K01998 - - 0.0000000000000000000000000000000000000492 156.0
TLS2_k127_1334169_48 Transmembrane secretion effector - - - 0.000000000000000000000000000000000006682 152.0
TLS2_k127_1334169_49 heme binding K21471,K21472 - - 0.000000000000000000000000000000003709 143.0
TLS2_k127_1334169_5 CoA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 519.0
TLS2_k127_1334169_50 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000002628 126.0
TLS2_k127_1334169_51 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000008451 125.0
TLS2_k127_1334169_52 BetI-type transcriptional repressor, C-terminal - - - 0.0000000000000000000000000002834 122.0
TLS2_k127_1334169_53 metal ion binding K13355 - - 0.0000000000000000000000003254 115.0
TLS2_k127_1334169_54 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.00000000000000000000009695 100.0
TLS2_k127_1334169_55 RDD family - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000005142 96.0
TLS2_k127_1334169_56 cheY-homologous receiver domain - - - 0.0000000000001285 77.0
TLS2_k127_1334169_57 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000002404 79.0
TLS2_k127_1334169_58 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000002042 52.0
TLS2_k127_1334169_6 COG1960 Acyl-CoA dehydrogenases K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 495.0
TLS2_k127_1334169_7 methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 466.0
TLS2_k127_1334169_8 FAD binding domain K00481 GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.14.13.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 461.0
TLS2_k127_1334169_9 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 440.0
TLS2_k127_1430722_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 8.457e-247 779.0
TLS2_k127_1430722_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002689 282.0
TLS2_k127_1430722_10 Phosphoglycerate mutase family K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.000000000000000000005207 106.0
TLS2_k127_1430722_11 Belongs to the phosphoglycerate mutase family K02226 - 3.1.3.73 0.000000000000000000006966 106.0
TLS2_k127_1430722_12 Universal stress protein - - - 0.000000000000000007267 89.0
TLS2_k127_1430722_13 2-phospho-L-lactate guanylyltransferase K14941 - 2.7.7.68 0.0000000000008761 76.0
TLS2_k127_1430722_14 PFAM Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.00000000003428 74.0
TLS2_k127_1430722_15 - - - - 0.00001725 53.0
TLS2_k127_1430722_2 DNA polymerase beta thumb K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000754 273.0
TLS2_k127_1430722_3 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000001013 231.0
TLS2_k127_1430722_4 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000006357 225.0
TLS2_k127_1430722_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000003724 192.0
TLS2_k127_1430722_6 Hydroxypyruvate reductase K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000007899 189.0
TLS2_k127_1430722_7 KR domain - - - 0.0000000000000000000000000000000000000217 156.0
TLS2_k127_1430722_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000006058 149.0
TLS2_k127_1430722_9 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000001289 139.0
TLS2_k127_1468548_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 608.0
TLS2_k127_1468548_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008988 282.0
TLS2_k127_1468548_2 PFAM Mur ligase family, glutamate ligase domain K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000001739 258.0
TLS2_k127_1468548_3 Bacterial trigger factor protein (TF) C-terminus K03545 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000436 258.0
TLS2_k127_1468548_4 Histidine kinase - - - 0.000005742 55.0
TLS2_k127_1644067_0 Glycosyl Transferase - - - 5.709e-245 783.0
TLS2_k127_1644067_1 ATPase P-type (Transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 570.0
TLS2_k127_1644067_10 - - - - 0.00000000002721 76.0
TLS2_k127_1644067_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 434.0
TLS2_k127_1644067_3 Glycosyl Transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 300.0
TLS2_k127_1644067_4 GCN5 family acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001308 273.0
TLS2_k127_1644067_5 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000001009 224.0
TLS2_k127_1644067_6 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000001399 223.0
TLS2_k127_1644067_7 Protein of unknown function (DUF1524) - - - 0.000000000000000000000000000000001181 135.0
TLS2_k127_1644067_8 Domain of unknown function (DUF1905) - - - 0.000000000000000000000003809 106.0
TLS2_k127_1644067_9 Belongs to the 'phage' integrase family - - - 0.00000000000000001264 92.0
TLS2_k127_1675682_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000001079 215.0
TLS2_k127_1675682_1 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000006032 206.0
TLS2_k127_1675682_2 Alpha/beta hydrolase family K01563 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016020,GO:0016787,GO:0016824,GO:0018786,GO:0019120,GO:0030312,GO:0042178,GO:0042197,GO:0042206,GO:0042221,GO:0044237,GO:0044248,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:1901575 3.8.1.5 0.000000000000000000000000000000000000000002062 169.0
TLS2_k127_1675682_3 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000001707 166.0
TLS2_k127_1675682_4 Flavin reductase like domain - - - 0.00000000000000000000000000000000000001219 150.0
TLS2_k127_1675682_5 exo-alpha-(2->6)-sialidase activity - - - 0.0000001757 63.0
TLS2_k127_1735539_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 486.0
TLS2_k127_1735539_1 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 476.0
TLS2_k127_1735539_10 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000007722 135.0
TLS2_k127_1735539_11 Protein of unknown function (DUF983) - - - 0.00000000000000000000007324 106.0
TLS2_k127_1735539_13 Phage integrase family - - - 0.0008835 51.0
TLS2_k127_1735539_2 pterin-4-alpha-carbinolamine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 353.0
TLS2_k127_1735539_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000001487 265.0
TLS2_k127_1735539_4 Hydroxymethylglutaryl-CoA lyase K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000001503 268.0
TLS2_k127_1735539_5 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002254 264.0
TLS2_k127_1735539_6 Pfam:PNPOx_C K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000006742 251.0
TLS2_k127_1735539_7 Metal-dependent hydrolases of the beta-lactamase superfamily III - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 - 0.0000000000000000000000000000000000000000000000269 179.0
TLS2_k127_1735539_8 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000005073 175.0
TLS2_k127_1735539_9 sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000169 154.0
TLS2_k127_1826710_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000007972 190.0
TLS2_k127_1826710_1 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000003057 172.0
TLS2_k127_1826710_2 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000001389 139.0
TLS2_k127_1826710_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000001498 137.0
TLS2_k127_1826710_4 Glycosyl hydrolase family 26 - - - 0.000000000000000000001347 109.0
TLS2_k127_1826710_5 COG3307 Lipid A core - O-antigen ligase and related enzymes K18814 - - 0.00001392 58.0
TLS2_k127_1835416_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1074.0
TLS2_k127_1835416_1 AAA ATPase forming ring-shaped complexes K13527 GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - 8.412e-219 692.0
TLS2_k127_1835416_10 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002276 261.0
TLS2_k127_1835416_11 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000008121 252.0
TLS2_k127_1835416_12 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000001865 244.0
TLS2_k127_1835416_13 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000000000002068 228.0
TLS2_k127_1835416_14 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000006053 209.0
TLS2_k127_1835416_15 iron dependent repressor - - - 0.00000000000000000000000000000000000000000000000000003607 193.0
TLS2_k127_1835416_16 Transmembrane secretion effector - - - 0.00000000000000000000000000000000004452 152.0
TLS2_k127_1835416_17 Vitamin K-dependent gamma-carboxylase - - - 0.00000000000000000000000001073 120.0
TLS2_k127_1835416_18 Horizontally Transferred TransMembrane Domain - - - 0.0000000000000000000000000124 122.0
TLS2_k127_1835416_19 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.000000000000000000001396 102.0
TLS2_k127_1835416_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 2.448e-209 666.0
TLS2_k127_1835416_20 - - - - 0.000000000000000000002363 94.0
TLS2_k127_1835416_21 - - - - 0.00000000000002355 84.0
TLS2_k127_1835416_22 Preprotein translocase SecG subunit K03075 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000003768 75.0
TLS2_k127_1835416_23 Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation K13570 - - 0.000000003175 61.0
TLS2_k127_1835416_24 methyltransferase - - - 0.00000004673 64.0
TLS2_k127_1835416_3 Pup-ligase protein K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 535.0
TLS2_k127_1835416_4 Integrase core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 452.0
TLS2_k127_1835416_5 GDP-mannose 4,6 dehydratase K01710,K01784 - 4.2.1.46,5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009406 425.0
TLS2_k127_1835416_6 Belongs to the phosphoglycerate kinase family K00927,K01803 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.7.2.3,5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 411.0
TLS2_k127_1835416_7 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005069 317.0
TLS2_k127_1835416_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008826 305.0
TLS2_k127_1835416_9 Displays ATPase and GTPase activities K06958 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007273 278.0
TLS2_k127_1835636_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 452.0
TLS2_k127_1835636_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 429.0
TLS2_k127_1835636_10 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000001005 233.0
TLS2_k127_1835636_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000001296 229.0
TLS2_k127_1835636_12 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000001047 222.0
TLS2_k127_1835636_13 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000006295 220.0
TLS2_k127_1835636_14 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000001561 211.0
TLS2_k127_1835636_15 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000005923 207.0
TLS2_k127_1835636_16 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000003751 189.0
TLS2_k127_1835636_17 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000003469 184.0
TLS2_k127_1835636_18 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000002754 170.0
TLS2_k127_1835636_19 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000001106 162.0
TLS2_k127_1835636_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009151 427.0
TLS2_k127_1835636_20 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000004763 165.0
TLS2_k127_1835636_21 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000000009791 172.0
TLS2_k127_1835636_22 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000004491 161.0
TLS2_k127_1835636_23 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000015 141.0
TLS2_k127_1835636_24 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000001865 136.0
TLS2_k127_1835636_25 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000002491 125.0
TLS2_k127_1835636_26 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000001883 117.0
TLS2_k127_1835636_27 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000002893 112.0
TLS2_k127_1835636_28 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000002303 105.0
TLS2_k127_1835636_29 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000002467 84.0
TLS2_k127_1835636_3 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009456 382.0
TLS2_k127_1835636_30 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000005704 75.0
TLS2_k127_1835636_31 - - - - 0.0000000000004649 74.0
TLS2_k127_1835636_32 Ribosomal protein L30 K02907 - - 0.000000000001 74.0
TLS2_k127_1835636_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 355.0
TLS2_k127_1835636_5 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009136 282.0
TLS2_k127_1835636_6 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002808 284.0
TLS2_k127_1835636_7 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000001385 271.0
TLS2_k127_1835636_8 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000342 256.0
TLS2_k127_1835636_9 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000001761 228.0
TLS2_k127_1926539_0 Isocitrate lyase K01637 - 4.1.3.1 1.353e-208 655.0
TLS2_k127_1926539_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 3.076e-206 667.0
TLS2_k127_1926539_10 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 428.0
TLS2_k127_1926539_11 IrrE N-terminal-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 436.0
TLS2_k127_1926539_12 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 401.0
TLS2_k127_1926539_13 Belongs to the CinA family K03742 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 346.0
TLS2_k127_1926539_14 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 327.0
TLS2_k127_1926539_15 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004377 271.0
TLS2_k127_1926539_16 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000002823 248.0
TLS2_k127_1926539_17 GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.000000000000000000000000000000000000000000000000000000000000006379 229.0
TLS2_k127_1926539_18 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000002059 232.0
TLS2_k127_1926539_19 Mazg nucleotide pyrophosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000001135 218.0
TLS2_k127_1926539_2 Belongs to the malate synthase family K01638 - 2.3.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006922 611.0
TLS2_k127_1926539_20 LexA DNA binding domain K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000000000000003927 205.0
TLS2_k127_1926539_21 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000003907 184.0
TLS2_k127_1926539_22 Lipid A biosynthesis K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.000000000000000000000000000000000000000002218 174.0
TLS2_k127_1926539_23 - - - - 0.000000000000000000000000000000000000003847 151.0
TLS2_k127_1926539_24 Serine carboxypeptidase - - - 0.00000000000000000000000000000000000005301 146.0
TLS2_k127_1926539_25 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000001146 151.0
TLS2_k127_1926539_26 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000001052 145.0
TLS2_k127_1926539_27 Zincin-like metallopeptidase - - - 0.000000000000000000000000000001327 126.0
TLS2_k127_1926539_28 LysE type translocator - - - 0.00000000000000000000000000009062 123.0
TLS2_k127_1926539_29 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000001603 110.0
TLS2_k127_1926539_3 elongation factor G K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 591.0
TLS2_k127_1926539_30 Patatin-like phospholipase - - - 0.00000000000000000000061 107.0
TLS2_k127_1926539_31 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000007248 100.0
TLS2_k127_1926539_32 - - - - 0.0000000000000000004888 91.0
TLS2_k127_1926539_33 - - - - 0.000000000000000002505 98.0
TLS2_k127_1926539_34 LysM domain - - - 0.00000133 54.0
TLS2_k127_1926539_35 - - - - 0.0001727 45.0
TLS2_k127_1926539_36 HNH endonuclease - - - 0.0003502 49.0
TLS2_k127_1926539_4 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 552.0
TLS2_k127_1926539_5 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 515.0
TLS2_k127_1926539_6 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 522.0
TLS2_k127_1926539_7 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 485.0
TLS2_k127_1926539_8 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 464.0
TLS2_k127_1926539_9 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 447.0
TLS2_k127_1969972_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1051.0
TLS2_k127_1969972_1 Heat shock 70 kDa protein K04043 - - 2.065e-262 821.0
TLS2_k127_1969972_10 MFS transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007607 284.0
TLS2_k127_1969972_11 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001447 260.0
TLS2_k127_1969972_12 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000001322 246.0
TLS2_k127_1969972_13 cyclic nucleotide binding K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000003661 236.0
TLS2_k127_1969972_14 peptide-methionine (R)-S-oxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000001885 205.0
TLS2_k127_1969972_15 Bacterial periplasmic substrate-binding proteins K02030 - - 0.000000000000000000000000000000000000000000000000000000009254 209.0
TLS2_k127_1969972_16 sequence-specific DNA binding K00567,K13529,K15051 - 2.1.1.63,3.2.2.21 0.00000000000000000000000000000000000000000000000000000004624 205.0
TLS2_k127_1969972_17 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000003938 177.0
TLS2_k127_1969972_18 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000001022 175.0
TLS2_k127_1969972_19 CHAD - - - 0.0000000000000000000000000000000000009129 155.0
TLS2_k127_1969972_2 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.771e-215 686.0
TLS2_k127_1969972_20 Domain of unknown function (DUF427) - - - 0.0000000000000000000000000000000007961 134.0
TLS2_k127_1969972_21 Pfam NUDIX - - - 0.000000000000000000000000000000003563 145.0
TLS2_k127_1969972_22 Low molecular weight phosphotyrosine protein phosphatase K01104 - 3.1.3.48 0.000000000000000000000000000000008974 134.0
TLS2_k127_1969972_23 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000001158 132.0
TLS2_k127_1969972_24 PFAM transcriptional regulator PadR family protein K10947 - - 0.00000000000000000000000000000002249 129.0
TLS2_k127_1969972_25 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000001164 129.0
TLS2_k127_1969972_26 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000000000000000004168 120.0
TLS2_k127_1969972_27 PFAM ABC transporter related K01990 - - 0.000000000000000000000000001342 121.0
TLS2_k127_1969972_28 - - - - 0.00000000000000000000004002 108.0
TLS2_k127_1969972_29 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000002129 102.0
TLS2_k127_1969972_3 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 603.0
TLS2_k127_1969972_30 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000006315 95.0
TLS2_k127_1969972_31 Multidrug ABC transporter permease - - - 0.0000000000000000004407 97.0
TLS2_k127_1969972_32 Glycopeptide antibiotics resistance protein - - - 0.00000000001301 73.0
TLS2_k127_1969972_33 NfeD-like C-terminal, partner-binding - - - 0.00001987 55.0
TLS2_k127_1969972_4 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009302 441.0
TLS2_k127_1969972_5 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 394.0
TLS2_k127_1969972_6 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 394.0
TLS2_k127_1969972_7 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 386.0
TLS2_k127_1969972_8 amino acid ABC transporter, ATP-binding protein K02028,K17076 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 323.0
TLS2_k127_1969972_9 ABC transporter K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 286.0
TLS2_k127_2203139_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1483.0
TLS2_k127_2203139_1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 610.0
TLS2_k127_2203139_10 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 354.0
TLS2_k127_2203139_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 362.0
TLS2_k127_2203139_12 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 284.0
TLS2_k127_2203139_13 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005683 293.0
TLS2_k127_2203139_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000002936 254.0
TLS2_k127_2203139_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000003929 233.0
TLS2_k127_2203139_16 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001057 229.0
TLS2_k127_2203139_17 membrane K07149 - - 0.000000000000000000000000000000000000000000000000000000000000001586 224.0
TLS2_k127_2203139_18 Cysteine-rich domain K18928 - - 0.000000000000000000000000000000000000000000000000000000004276 209.0
TLS2_k127_2203139_19 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000004147 205.0
TLS2_k127_2203139_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 552.0
TLS2_k127_2203139_20 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000004421 196.0
TLS2_k127_2203139_21 transferase activity, transferring alkyl or aryl (other than methyl) groups K22205 - - 0.00000000000000000000000000000000000000000000000000003854 211.0
TLS2_k127_2203139_22 Cytochrome b(C-terminal)/b6/petD - - - 0.0000000000000000000000000000000000000000000000000001355 207.0
TLS2_k127_2203139_23 Rieske 2Fe-2S - - - 0.000000000000000000000000000000000000000000205 171.0
TLS2_k127_2203139_24 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000002153 156.0
TLS2_k127_2203139_25 HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like) K01560 - 3.8.1.2 0.0000000000000000000000000000000000000002074 158.0
TLS2_k127_2203139_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000004858 156.0
TLS2_k127_2203139_27 Thioredoxin-like [2Fe-2S] ferredoxin K00334 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000000004166 154.0
TLS2_k127_2203139_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000003076 139.0
TLS2_k127_2203139_29 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000001477 138.0
TLS2_k127_2203139_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 520.0
TLS2_k127_2203139_30 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 0.000000000000000000000000000003058 137.0
TLS2_k127_2203139_31 heme binding K21471,K21472 - - 0.000000000000000000000000000003705 133.0
TLS2_k127_2203139_32 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000006684 123.0
TLS2_k127_2203139_33 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 0.0000000000000000000000000004672 119.0
TLS2_k127_2203139_34 PFAM PspC domain protein K03973 - - 0.00000000000000000000000007346 113.0
TLS2_k127_2203139_35 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000005475 111.0
TLS2_k127_2203139_36 LUD domain K00782 - - 0.000000000000000000000007915 111.0
TLS2_k127_2203139_37 - - - - 0.00000000000000000000002661 106.0
TLS2_k127_2203139_38 SnoaL-like polyketide cyclase - - - 0.000000000000000005018 89.0
TLS2_k127_2203139_39 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.0000000000000106 85.0
TLS2_k127_2203139_4 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 490.0
TLS2_k127_2203139_40 Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA K06947 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000002295 85.0
TLS2_k127_2203139_41 positive regulation of macromolecule biosynthetic process - - - 0.0000000000001341 79.0
TLS2_k127_2203139_42 Putative bacterial sensory transduction regulator - - - 0.00000000002227 70.0
TLS2_k127_2203139_43 peptidase inhibitor activity - - - 0.00000000005158 71.0
TLS2_k127_2203139_44 - - - - 0.000000002602 65.0
TLS2_k127_2203139_45 Cytochrome C oxidase, mono-heme subunit/FixO - - - 0.00000002097 66.0
TLS2_k127_2203139_46 Glutaredoxin-like domain (DUF836) - - - 0.00000003465 63.0
TLS2_k127_2203139_47 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000002352 61.0
TLS2_k127_2203139_48 Alpha beta hydrolase K16050 - 3.7.1.17 0.000002377 60.0
TLS2_k127_2203139_49 antibiotic catabolic process - - - 0.00000437 58.0
TLS2_k127_2203139_5 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 473.0
TLS2_k127_2203139_50 - - - - 0.0009052 49.0
TLS2_k127_2203139_6 Amino acid dehydrogenase K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 445.0
TLS2_k127_2203139_7 FAD binding domain K21401 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 425.0
TLS2_k127_2203139_8 COG0025 NhaP-type Na H and K H antiporters - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 406.0
TLS2_k127_2203139_9 Cytochrome b/b6/petB K03891 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 394.0
TLS2_k127_2265157_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 6.736e-226 721.0
TLS2_k127_2265157_1 L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 591.0
TLS2_k127_2265157_2 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 336.0
TLS2_k127_2265157_3 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000001555 254.0
TLS2_k127_2265157_4 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.00000000000000000000000000000000000000000000000000000002067 201.0
TLS2_k127_2265157_5 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000001628 174.0
TLS2_k127_2265157_6 Preprotein translocase subunit K03210 - - 0.0000000000000002251 84.0
TLS2_k127_2381900_0 Ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 487.0
TLS2_k127_2381900_1 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000007035 239.0
TLS2_k127_2381900_2 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000000000001053 152.0
TLS2_k127_2531706_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.4.4.2 0.0 1221.0
TLS2_k127_2531706_1 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1091.0
TLS2_k127_2531706_10 Belongs to the GPAT DAPAT family K00631 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 429.0
TLS2_k127_2531706_11 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 406.0
TLS2_k127_2531706_12 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008115 387.0
TLS2_k127_2531706_13 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 377.0
TLS2_k127_2531706_14 Belongs to the helicase family. UvrD subfamily K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 395.0
TLS2_k127_2531706_15 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 351.0
TLS2_k127_2531706_16 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 349.0
TLS2_k127_2531706_17 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 336.0
TLS2_k127_2531706_18 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 336.0
TLS2_k127_2531706_19 transferase activity, transferring glycosyl groups K18818 - 2.4.1.269 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 327.0
TLS2_k127_2531706_2 belongs to the aldehyde dehydrogenase family K00130,K00151 - 1.2.1.60,1.2.1.8 1.774e-220 692.0
TLS2_k127_2531706_20 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 341.0
TLS2_k127_2531706_21 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K15893 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 317.0
TLS2_k127_2531706_22 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000499 306.0
TLS2_k127_2531706_23 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005295 303.0
TLS2_k127_2531706_24 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 GO:0008150,GO:0040007 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 292.0
TLS2_k127_2531706_25 Belongs to the helicase family. UvrD subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 312.0
TLS2_k127_2531706_26 phosphoenolpyruvate carboxykinase (ATP) activity K01610 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 4.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001808 296.0
TLS2_k127_2531706_27 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005329 295.0
TLS2_k127_2531706_28 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002278 276.0
TLS2_k127_2531706_29 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003274 282.0
TLS2_k127_2531706_3 COG0433 Predicted ATPase K06915 - - 1.584e-213 677.0
TLS2_k127_2531706_30 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000003557 278.0
TLS2_k127_2531706_31 PFAM extracellular solute-binding protein, family 5 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002167 282.0
TLS2_k127_2531706_32 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001219 261.0
TLS2_k127_2531706_33 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001254 265.0
TLS2_k127_2531706_34 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001555 265.0
TLS2_k127_2531706_35 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006275 266.0
TLS2_k127_2531706_36 transport, permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000517 247.0
TLS2_k127_2531706_37 COGs COG2380 conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000001635 237.0
TLS2_k127_2531706_38 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.00000000000000000000000000000000000000000000000000000000000000005296 227.0
TLS2_k127_2531706_39 Provides the (R)-glutamate required for cell wall biosynthesis K01776 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.3 0.000000000000000000000000000000000000000000000000000000004563 215.0
TLS2_k127_2531706_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 7.722e-204 668.0
TLS2_k127_2531706_40 Protein of unknown function (DUF2800) K07465 - - 0.00000000000000000000000000000000000000000000000000000004806 207.0
TLS2_k127_2531706_41 chorismate binding enzyme K02552 - 5.4.4.2 0.00000000000000000000000000000000000000000000000000001622 202.0
TLS2_k127_2531706_42 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000001378 196.0
TLS2_k127_2531706_43 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000004633 196.0
TLS2_k127_2531706_44 alcohol dehydrogenase K00001,K00008 - 1.1.1.1,1.1.1.14 0.00000000000000000000000000000000000000000000000005312 193.0
TLS2_k127_2531706_45 ABC transporter - - - 0.0000000000000000000000000000000000000000000001803 183.0
TLS2_k127_2531706_46 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000002986 181.0
TLS2_k127_2531706_47 BioY protein K03523 - - 0.000000000000000000000000000000000000000000001405 171.0
TLS2_k127_2531706_48 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000003209 166.0
TLS2_k127_2531706_49 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000008253 167.0
TLS2_k127_2531706_5 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 505.0
TLS2_k127_2531706_50 Histidine triad (Hit) protein K02503 - - 0.000000000000000000000000000000000000000001983 159.0
TLS2_k127_2531706_51 - - - - 0.000000000000000000000000000000000000000003116 160.0
TLS2_k127_2531706_52 iron-sulfur cluster assembly K07400 - - 0.000000000000000000000000000000000000000005953 161.0
TLS2_k127_2531706_53 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000001217 169.0
TLS2_k127_2531706_54 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000001797 157.0
TLS2_k127_2531706_55 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.000000000000000000000000000000000000004517 153.0
TLS2_k127_2531706_56 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000007918 152.0
TLS2_k127_2531706_57 ABC transporter - - - 0.00000000000000000000000000000000105 149.0
TLS2_k127_2531706_58 Putative inner membrane exporter, YdcZ K09936 - - 0.000000000000000000000000000003651 124.0
TLS2_k127_2531706_59 Histidine kinase - - - 0.00000000000000000000000001477 123.0
TLS2_k127_2531706_6 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 483.0
TLS2_k127_2531706_60 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000002112 108.0
TLS2_k127_2531706_61 PFAM Thiamin pyrophosphokinase catalytic K00949 - 2.7.6.2 0.00000000000000001009 91.0
TLS2_k127_2531706_62 PFAM Mov34 MPN PAD-1 family protein K21140 - 3.13.1.6 0.00000000000000002149 89.0
TLS2_k127_2531706_63 Diacylglycerol kinase - - - 0.000000000000004571 86.0
TLS2_k127_2531706_64 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 - 3.1.31.1 0.0000000000000118 83.0
TLS2_k127_2531706_65 Copper binding proteins, plastocyanin/azurin family - - - 0.000000008705 63.0
TLS2_k127_2531706_66 Cytochrome C oxidase, cbb3-type, subunit III K12263 - - 0.0000002242 58.0
TLS2_k127_2531706_67 - - - - 0.0000006176 57.0
TLS2_k127_2531706_68 HNH nucleases - - - 0.0001318 46.0
TLS2_k127_2531706_7 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 437.0
TLS2_k127_2531706_8 CoA-transferase family III K01796 - 5.1.99.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 433.0
TLS2_k127_2531706_9 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 445.0
TLS2_k127_264184_0 Dehydrogenase K00140 - 1.2.1.18,1.2.1.27 2.27e-215 678.0
TLS2_k127_264184_1 GTP-binding protein TypA K06207 - - 4.43e-201 644.0
TLS2_k127_264184_10 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 407.0
TLS2_k127_264184_11 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 417.0
TLS2_k127_264184_12 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 374.0
TLS2_k127_264184_13 Belongs to the binding-protein-dependent transport system permease family K10440,K10441 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 379.0
TLS2_k127_264184_14 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 367.0
TLS2_k127_264184_15 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004479 383.0
TLS2_k127_264184_16 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009498 353.0
TLS2_k127_264184_17 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006801 351.0
TLS2_k127_264184_18 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 327.0
TLS2_k127_264184_19 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 306.0
TLS2_k127_264184_2 Dihydropyrimidinase K01464 - 3.5.2.2 3.562e-196 621.0
TLS2_k127_264184_20 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 292.0
TLS2_k127_264184_21 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 295.0
TLS2_k127_264184_22 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000681 293.0
TLS2_k127_264184_23 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001345 286.0
TLS2_k127_264184_24 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000001372 245.0
TLS2_k127_264184_25 ATP- GTP-binding protein K06945 - - 0.000000000000000000000000000000000000000000000000000000000000000000398 239.0
TLS2_k127_264184_26 Periplasmic binding protein domain K10439 - - 0.000000000000000000000000000000000000000000000000000000000000008414 235.0
TLS2_k127_264184_27 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.0000000000000000000000000000000000000000000000000000002758 207.0
TLS2_k127_264184_28 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000003564 209.0
TLS2_k127_264184_29 Cro/C1-type HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000005468 198.0
TLS2_k127_264184_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00140,K00823 - 1.2.1.18,1.2.1.27,2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 572.0
TLS2_k127_264184_30 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000124 196.0
TLS2_k127_264184_31 Peroxiredoxin K04063 - - 0.000000000000000000000000000000000000001181 158.0
TLS2_k127_264184_32 Beta-lactamase enzyme family - - - 0.0000000000000000000000000000002408 135.0
TLS2_k127_264184_33 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000001787 123.0
TLS2_k127_264184_34 Domain of unknown function (DUF4260) - - - 0.00000000000000000000000000007431 130.0
TLS2_k127_264184_35 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000002585 114.0
TLS2_k127_264184_36 Roadblock lc7 family protein K07131 - - 0.00000000000000000000000001206 115.0
TLS2_k127_264184_37 CGNR zinc finger - - - 0.0000000000000000000001422 110.0
TLS2_k127_264184_38 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.0000000000000000001901 91.0
TLS2_k127_264184_39 Bacterial-like globin - - - 0.000000000000000003227 89.0
TLS2_k127_264184_4 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 564.0
TLS2_k127_264184_40 PFAM regulatory protein LuxR - - - 0.00000000000000001758 88.0
TLS2_k127_264184_41 - - - - 0.00000000000000008707 89.0
TLS2_k127_264184_42 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000001662 78.0
TLS2_k127_264184_43 Histidine kinase - - - 0.000000000000004636 86.0
TLS2_k127_264184_44 RNA polymerase sigma factor K03088 - - 0.00000000000006465 79.0
TLS2_k127_264184_45 Protein of unknown function (DUF742) - - - 0.000000000002004 72.0
TLS2_k127_264184_46 Glucose / Sorbosone dehydrogenase - - - 0.000000000002389 73.0
TLS2_k127_264184_47 Domain of unknown function (DUF1992) - - - 0.000000000008448 66.0
TLS2_k127_264184_48 SnoaL-like domain K06893 - - 0.00001536 55.0
TLS2_k127_264184_49 - - - - 0.0001073 46.0
TLS2_k127_264184_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 492.0
TLS2_k127_264184_6 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 493.0
TLS2_k127_264184_7 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 477.0
TLS2_k127_264184_8 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 470.0
TLS2_k127_264184_9 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 436.0
TLS2_k127_2842961_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 3.885e-242 775.0
TLS2_k127_2842961_1 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 627.0
TLS2_k127_2842961_10 Transcriptional regulator - - - 0.000000000000000000000000000001095 126.0
TLS2_k127_2842961_11 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000006577 123.0
TLS2_k127_2842961_12 chlorophyll binding - - - 0.00000000000000000000000000001174 136.0
TLS2_k127_2842961_13 Pkd domain containing protein - - - 0.000000000000000000003353 111.0
TLS2_k127_2842961_14 DNA alkylation repair - - - 0.000000000000000002026 87.0
TLS2_k127_2842961_15 Glucose sorbosone - - - 0.00000000000002165 89.0
TLS2_k127_2842961_16 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000007035 69.0
TLS2_k127_2842961_17 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.00007813 49.0
TLS2_k127_2842961_18 metallopeptidase activity K01637 - 4.1.3.1 0.00007967 53.0
TLS2_k127_2842961_2 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 446.0
TLS2_k127_2842961_3 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 440.0
TLS2_k127_2842961_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 375.0
TLS2_k127_2842961_5 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008486 303.0
TLS2_k127_2842961_6 Sulfate transporter K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 316.0
TLS2_k127_2842961_7 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000288 239.0
TLS2_k127_2842961_8 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768,K03320 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000001335 213.0
TLS2_k127_2842961_9 regulatory protein, arsR - - - 0.0000000000000000000000000000003361 124.0
TLS2_k127_2875593_0 Oxidoreductase FAD-binding domain K02613 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 320.0
TLS2_k127_2875593_1 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000003745 259.0
TLS2_k127_2875593_2 Iron-sulfur cluster assembly protein K02612 - - 0.00000000000000000000000000000000000000000000000003246 187.0
TLS2_k127_2875593_3 Phenylacetate-CoA oxygenase K02610 - - 0.00000000000000017 80.0
TLS2_k127_2911563_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 7.128e-248 790.0
TLS2_k127_2911563_1 ATPase activity K16922 - - 2.302e-231 751.0
TLS2_k127_2911563_10 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005594 518.0
TLS2_k127_2911563_11 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 479.0
TLS2_k127_2911563_12 Belongs to the HpcH HpaI aldolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005887 475.0
TLS2_k127_2911563_13 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004521 482.0
TLS2_k127_2911563_14 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 464.0
TLS2_k127_2911563_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006757 448.0
TLS2_k127_2911563_16 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 452.0
TLS2_k127_2911563_17 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 436.0
TLS2_k127_2911563_18 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 427.0
TLS2_k127_2911563_19 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 420.0
TLS2_k127_2911563_2 Glutamine synthetase, beta-Grasp domain K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 2.507e-226 708.0
TLS2_k127_2911563_20 Adenosine/AMP deaminase K01488 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 409.0
TLS2_k127_2911563_21 Belongs to the GARS family K01945,K11788 GO:0008150,GO:0040007 6.3.3.1,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 372.0
TLS2_k127_2911563_22 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 372.0
TLS2_k127_2911563_23 Thioesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007702 363.0
TLS2_k127_2911563_24 PFAM Transketolase central region K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005874 375.0
TLS2_k127_2911563_25 lactoylglutathione lyase activity K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 331.0
TLS2_k127_2911563_26 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 350.0
TLS2_k127_2911563_27 Belongs to the SAICAR synthetase family K01923,K01945 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 323.0
TLS2_k127_2911563_28 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 295.0
TLS2_k127_2911563_29 -acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 287.0
TLS2_k127_2911563_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 9.839e-222 709.0
TLS2_k127_2911563_30 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002774 287.0
TLS2_k127_2911563_31 PFAM EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003286 254.0
TLS2_k127_2911563_32 cytochrome c oxidase K02351,K02862 - - 0.000000000000000000000000000000000000000000000000000000000000000000008523 242.0
TLS2_k127_2911563_33 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000009367 244.0
TLS2_k127_2911563_34 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000005135 236.0
TLS2_k127_2911563_35 EamA-like transporter family K15269 - - 0.0000000000000000000000000000000000000000000000000000000000000000006391 243.0
TLS2_k127_2911563_36 thiolester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000009959 237.0
TLS2_k127_2911563_37 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000299 231.0
TLS2_k127_2911563_38 CO dehydrogenase flavoprotein C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000002939 226.0
TLS2_k127_2911563_39 Fe-S oxidoreductase K11473 - - 0.0000000000000000000000000000000000000000000000000000000000001212 230.0
TLS2_k127_2911563_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 592.0
TLS2_k127_2911563_40 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.00000000000000000000000000000000000000000000000000000000003234 219.0
TLS2_k127_2911563_41 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000008784 207.0
TLS2_k127_2911563_42 SCO1 SenC K07152 - - 0.000000000000000000000000000000000000000000000001732 180.0
TLS2_k127_2911563_43 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000006248 177.0
TLS2_k127_2911563_44 DNA synthesis involved in DNA repair - - - 0.0000000000000000000000000000000000000000000001419 179.0
TLS2_k127_2911563_45 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000001945 176.0
TLS2_k127_2911563_46 FR47-like protein K06976 - - 0.00000000000000000000000000000000000000000008884 171.0
TLS2_k127_2911563_47 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000001379 174.0
TLS2_k127_2911563_48 FAD binding domain K11472 - - 0.000000000000000000000000000000000000000000226 174.0
TLS2_k127_2911563_49 Tetratricopeptide repeat protein - - - 0.00000000000000000000000000000000000000003469 156.0
TLS2_k127_2911563_5 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 588.0
TLS2_k127_2911563_50 BON domain - - - 0.0000000000000000000000000000000000000005535 158.0
TLS2_k127_2911563_51 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000009182 151.0
TLS2_k127_2911563_52 MerR family regulatory protein - - - 0.000000000000000000000000000000000002018 156.0
TLS2_k127_2911563_53 Secreted repeat of unknown function - - - 0.0000000000000000000000000000000001531 140.0
TLS2_k127_2911563_54 - - - - 0.000000000000000000000000000002367 131.0
TLS2_k127_2911563_55 - - - - 0.000000000000000000000000008211 122.0
TLS2_k127_2911563_56 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.0000000000000000000000009877 108.0
TLS2_k127_2911563_57 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000001077 117.0
TLS2_k127_2911563_58 transcriptional - - - 0.000000000000000000003262 106.0
TLS2_k127_2911563_59 Anti-sigma-K factor rskA - - - 0.000000000000000001469 94.0
TLS2_k127_2911563_6 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 540.0
TLS2_k127_2911563_60 Acetyltransferase (GNAT) family - - - 0.00000000000000003896 93.0
TLS2_k127_2911563_61 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000003905 77.0
TLS2_k127_2911563_62 - - - - 0.0000000000007805 81.0
TLS2_k127_2911563_63 Copper chaperone PCu(A)C K09796 - - 0.0000000000008386 76.0
TLS2_k127_2911563_64 Scaffold protein Nfu NifU - - - 0.000000000003674 69.0
TLS2_k127_2911563_65 methyltransferase activity - - - 0.000000000005382 74.0
TLS2_k127_2911563_66 Methylates ribosomal protein L11 K02687 - - 0.00000000009434 71.0
TLS2_k127_2911563_67 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.000000008131 66.0
TLS2_k127_2911563_68 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.0001505 51.0
TLS2_k127_2911563_69 Uncharacterised protein family UPF0066 - - - 0.0004512 44.0
TLS2_k127_2911563_7 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 537.0
TLS2_k127_2911563_8 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 537.0
TLS2_k127_2911563_9 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 513.0
TLS2_k127_2915085_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009967 353.0
TLS2_k127_2915085_1 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000004587 201.0
TLS2_k127_2915085_2 MDMPI C-terminal domain - - - 0.00000000000000000000000001327 118.0
TLS2_k127_2936998_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 2.9e-295 923.0
TLS2_k127_2936998_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000006741 216.0
TLS2_k127_2936998_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000003038 203.0
TLS2_k127_2936998_3 Elongation factor K02358 - - 0.00000000000000000381 84.0
TLS2_k127_2986059_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 1.171e-296 946.0
TLS2_k127_2986059_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 1.156e-242 779.0
TLS2_k127_2986059_10 TIGRFAM MazG family protein K02428,K02499 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000815 299.0
TLS2_k127_2986059_11 enoyl-CoA hydratase K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000006259 222.0
TLS2_k127_2986059_12 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000001019 198.0
TLS2_k127_2986059_13 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000001185 202.0
TLS2_k127_2986059_14 Cache domain - - - 0.000000000000000000000000000000000000000000000000003449 208.0
TLS2_k127_2986059_15 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000008313 174.0
TLS2_k127_2986059_16 acetylesterase activity - - - 0.0000000000000000000000000000000000000003649 160.0
TLS2_k127_2986059_17 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000007915 154.0
TLS2_k127_2986059_18 YCII-related domain - - - 0.000000000000000000000000000000000003091 141.0
TLS2_k127_2986059_19 Hydrolase of the alpha beta-hydrolase K07020 - - 0.000000000000000000000000000000000009753 147.0
TLS2_k127_2986059_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 4.348e-198 629.0
TLS2_k127_2986059_20 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000004201 130.0
TLS2_k127_2986059_21 Methyltransferase type 11 - - - 0.0000000000000000000000000000009651 129.0
TLS2_k127_2986059_22 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000007421 126.0
TLS2_k127_2986059_23 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000008876 126.0
TLS2_k127_2986059_24 Protein of unknown function (DUF501) K09009 - - 0.0000000000000000000000000005652 124.0
TLS2_k127_2986059_25 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K01802,K07533 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 0.00000000000168 78.0
TLS2_k127_2986059_26 Septum formation initiator - - - 0.0001312 53.0
TLS2_k127_2986059_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 531.0
TLS2_k127_2986059_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 412.0
TLS2_k127_2986059_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 420.0
TLS2_k127_2986059_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005834 362.0
TLS2_k127_2986059_7 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 314.0
TLS2_k127_2986059_8 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 311.0
TLS2_k127_2986059_9 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 308.0
TLS2_k127_312155_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 3.206e-304 952.0
TLS2_k127_312155_1 TrkA-N domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 408.0
TLS2_k127_312155_10 Dihydrodipicolinate synthetase family K18123 - 4.1.3.16 0.000000000000000000000000000000004289 141.0
TLS2_k127_312155_11 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000001281 135.0
TLS2_k127_312155_12 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 - - 0.000000000000000000000000000419 115.0
TLS2_k127_312155_13 Sigma-70, region 4 - - - 0.0000000000000000000000001399 113.0
TLS2_k127_312155_14 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000002974 105.0
TLS2_k127_312155_15 Type II secretion system (T2SS), protein F K12511 - - 0.0000000000000007687 91.0
TLS2_k127_312155_16 CobQ/CobB/MinD/ParA nucleotide binding domain - - - 0.00000000001345 77.0
TLS2_k127_312155_17 exo-alpha-(2->6)-sialidase activity - - - 0.00000000002389 76.0
TLS2_k127_312155_18 - - - - 0.000000001784 69.0
TLS2_k127_312155_19 Cupin domain - - - 0.000000003374 63.0
TLS2_k127_312155_2 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005996 391.0
TLS2_k127_312155_20 TadE-like protein - - - 0.00000001611 66.0
TLS2_k127_312155_21 PFAM TadE family protein - - - 0.000000392 59.0
TLS2_k127_312155_22 sterol carrier protein - - - 0.0000005062 57.0
TLS2_k127_312155_23 TadE-like protein - - - 0.000001376 57.0
TLS2_k127_312155_24 Membrane K08984 - - 0.000009591 56.0
TLS2_k127_312155_25 TadE-like protein - - - 0.00001237 55.0
TLS2_k127_312155_26 Helix-turn-helix domain - - - 0.00002308 50.0
TLS2_k127_312155_27 - - - - 0.00002828 54.0
TLS2_k127_312155_3 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005813 274.0
TLS2_k127_312155_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001463 272.0
TLS2_k127_312155_5 Type II/IV secretion system protein K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000002062 251.0
TLS2_k127_312155_6 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000002114 183.0
TLS2_k127_312155_7 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000391 177.0
TLS2_k127_312155_8 membrane - - - 0.00000000000000000000000000000000000000002962 160.0
TLS2_k127_312155_9 Protein of unknown function (DUF2587) - GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000007974 144.0
TLS2_k127_3122411_0 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 488.0
TLS2_k127_3122411_1 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 324.0
TLS2_k127_3122411_2 Conserved protein of dim6 ntab family - - - 0.000000000000000000000000000000000000000000000009978 179.0
TLS2_k127_3122411_3 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K01185,K02395,K19223 - 3.2.1.17 0.000000000000000000000000000000000005533 151.0
TLS2_k127_3122411_4 Peptidase family M23 K21472 - - 0.0000000000000000000006759 108.0
TLS2_k127_3122411_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000001165 57.0
TLS2_k127_3228014_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004534 277.0
TLS2_k127_3228014_1 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000004854 236.0
TLS2_k127_3228014_2 (mono)amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000002564 234.0
TLS2_k127_3228014_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000001375 203.0
TLS2_k127_3228014_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000005994 169.0
TLS2_k127_3228014_5 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000002573 132.0
TLS2_k127_3228014_6 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000000002581 84.0
TLS2_k127_3228014_7 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000009888 59.0
TLS2_k127_3228014_8 N-terminal half of MaoC dehydratase - - - 0.000000002052 69.0
TLS2_k127_3228014_9 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000001174 57.0
TLS2_k127_3309457_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 347.0
TLS2_k127_3390923_0 Acyl-CoA dehydrogenase N terminal - - - 1.283e-210 670.0
TLS2_k127_3390923_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 454.0
TLS2_k127_3390923_10 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000001192 209.0
TLS2_k127_3390923_11 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000003199 189.0
TLS2_k127_3390923_12 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000007476 190.0
TLS2_k127_3390923_13 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000002125 194.0
TLS2_k127_3390923_14 pathogenesis - - - 0.00000000000000000000000000000000000000000003931 181.0
TLS2_k127_3390923_15 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000001175 159.0
TLS2_k127_3390923_16 - - - - 0.000000000000000000000000000000000000001423 164.0
TLS2_k127_3390923_18 F420-dependent oxidoreductase K04091 - 1.14.14.5 0.000000000000000000000000000000000001139 154.0
TLS2_k127_3390923_19 3-demethylubiquinone-9 3-O-methyltransferase activity K20444 - - 0.000000000000000000000000000000000003393 152.0
TLS2_k127_3390923_2 TIGRFAM Dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 422.0
TLS2_k127_3390923_20 Predicted membrane protein (DUF2142) - - - 0.0000000000000000000000000000002773 141.0
TLS2_k127_3390923_21 Putative peptidoglycan binding domain - - - 0.000000000000000000000000000002936 136.0
TLS2_k127_3390923_22 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000001422 123.0
TLS2_k127_3390923_24 hydrolase of the alpha beta superfamily K07018 - - 0.0000000000000000004138 96.0
TLS2_k127_3390923_25 transferase activity, transferring glycosyl groups - - - 0.0000000000000001295 92.0
TLS2_k127_3390923_26 polysaccharide biosynthetic process - GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704 - 0.00000000001708 76.0
TLS2_k127_3390923_28 Bacterial regulatory proteins, tetR family - - - 0.0000004067 59.0
TLS2_k127_3390923_3 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000321 387.0
TLS2_k127_3390923_4 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 360.0
TLS2_k127_3390923_5 Creatinase/Prolidase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 349.0
TLS2_k127_3390923_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004501 340.0
TLS2_k127_3390923_7 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 303.0
TLS2_k127_3390923_8 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000006384 252.0
TLS2_k127_3390923_9 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000005162 207.0
TLS2_k127_3408290_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0 1341.0
TLS2_k127_3408290_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 542.0
TLS2_k127_3408290_10 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000007797 216.0
TLS2_k127_3408290_11 - - - - 0.0000000000000000000000000000000000000000000000000000000001163 220.0
TLS2_k127_3408290_12 Cell envelope-related transcriptional attenuator domain - - - 0.000000000000000000000000000000000000000000000000000000000271 220.0
TLS2_k127_3408290_13 ADP-ribosylglycohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000212 209.0
TLS2_k127_3408290_14 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000001775 195.0
TLS2_k127_3408290_15 Sigma-70 region 2 - - - 0.000000000000000000000000000000000000000000007266 181.0
TLS2_k127_3408290_16 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000001672 188.0
TLS2_k127_3408290_17 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000009486 152.0
TLS2_k127_3408290_18 Fungal trichothecene efflux pump (TRI12) - - - 0.000000000000000000000000000000000000001502 165.0
TLS2_k127_3408290_19 protein conserved in bacteria - - - 0.00000000000000000000000000000000001599 146.0
TLS2_k127_3408290_2 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 535.0
TLS2_k127_3408290_20 PAS PAC sensor signal transduction histidine kinase K18350 - 2.7.13.3 0.0000000000000000000000000000000002317 151.0
TLS2_k127_3408290_21 DoxX K15977 - - 0.000000000000000000000000000008478 130.0
TLS2_k127_3408290_22 PFAM regulatory protein AsnC Lrp family - - - 0.0000000000000000000004465 97.0
TLS2_k127_3408290_23 Gram-negative-bacterium-type cell wall biogenesis - - - 0.000000000000000000008359 99.0
TLS2_k127_3408290_24 Transcriptional regulator - - - 0.0000000000000000001055 92.0
TLS2_k127_3408290_25 TIGRFAM spore coat assembly protein SafA - - - 0.00000000000000009528 90.0
TLS2_k127_3408290_26 - - - - 0.000000000000007574 79.0
TLS2_k127_3408290_27 FR47-like protein - - - 0.0000000000385 71.0
TLS2_k127_3408290_28 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000001333 68.0
TLS2_k127_3408290_29 Transcription regulator MerR, DNA binding - - - 0.0000006207 59.0
TLS2_k127_3408290_3 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 501.0
TLS2_k127_3408290_30 electron transfer activity K05337 - - 0.000001571 55.0
TLS2_k127_3408290_31 RES - - - 0.0002695 52.0
TLS2_k127_3408290_32 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.0002844 47.0
TLS2_k127_3408290_33 - - - - 0.0009685 48.0
TLS2_k127_3408290_4 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 452.0
TLS2_k127_3408290_5 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 350.0
TLS2_k127_3408290_6 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 291.0
TLS2_k127_3408290_7 TIGRFAM RecB family nuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 305.0
TLS2_k127_3408290_8 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000105 285.0
TLS2_k127_3408290_9 Protein of unknown function (DUF3494) - - - 0.000000000000000000000000000000000000000000000000000000000000000009767 237.0
TLS2_k127_3436738_0 ATPase with chaperone activity K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 398.0
TLS2_k127_3436738_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 313.0
TLS2_k127_3436738_10 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000005913 205.0
TLS2_k127_3436738_11 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.00000000000000000000000000000000000000000000000005457 188.0
TLS2_k127_3436738_12 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000000002391 167.0
TLS2_k127_3436738_13 Protein of unknown function (DUF1254) - - - 0.000000000000000000000000000000000000000000009934 169.0
TLS2_k127_3436738_14 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000001222 167.0
TLS2_k127_3436738_15 Protein of unknown function (DUF2469) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000004468 152.0
TLS2_k127_3436738_16 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000000000000000193 155.0
TLS2_k127_3436738_17 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily - - - 0.0000000000000000000000000000000008719 148.0
TLS2_k127_3436738_18 - - - - 0.0000000000000000005432 90.0
TLS2_k127_3436738_19 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.000000005899 65.0
TLS2_k127_3436738_2 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 293.0
TLS2_k127_3436738_20 ABC-type transport system involved in multi-copper enzyme maturation permease component - - - 0.000001676 59.0
TLS2_k127_3436738_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 287.0
TLS2_k127_3436738_4 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001261 260.0
TLS2_k127_3436738_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000003248 252.0
TLS2_k127_3436738_6 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.000000000000000000000000000000000000000000000000000000000000000001211 237.0
TLS2_k127_3436738_7 Belongs to the RNA methyltransferase TrmD family K00554,K01770 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000005364 231.0
TLS2_k127_3436738_8 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000005148 212.0
TLS2_k127_3436738_9 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000123 214.0
TLS2_k127_3452778_0 WD40 repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005359 267.0
TLS2_k127_3452778_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000001091 183.0
TLS2_k127_3558891_0 DEAD DEAH box helicase K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 456.0
TLS2_k127_3558891_1 Sigma-70, region 4 K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000003128 243.0
TLS2_k127_3558891_2 Multicopper oxidase - - - 0.000000000000000000459 95.0
TLS2_k127_3590714_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 483.0
TLS2_k127_3590714_1 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 426.0
TLS2_k127_3590714_10 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000001792 195.0
TLS2_k127_3590714_11 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000006423 199.0
TLS2_k127_3590714_12 phosphatase activity K05967 - - 0.0000000000000000000000000000000000000000000000009398 184.0
TLS2_k127_3590714_13 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.000000000000000000000000000000000000000000001588 179.0
TLS2_k127_3590714_14 PFAM binding-protein-dependent transport systems inner membrane component K02042 - - 0.000000000000000000000000000000000000000000002575 182.0
TLS2_k127_3590714_15 PspC domain - - - 0.0000000000000000000000005713 117.0
TLS2_k127_3590714_16 RNA recognition motif - - - 0.00000000000000000000003903 102.0
TLS2_k127_3590714_17 - K01992 - - 0.00000000000000006376 88.0
TLS2_k127_3590714_18 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.0000000007582 64.0
TLS2_k127_3590714_19 Helix-turn-helix domain - - - 0.00000002036 63.0
TLS2_k127_3590714_2 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 396.0
TLS2_k127_3590714_20 - - - - 0.00000002667 63.0
TLS2_k127_3590714_3 SMART Metal-dependent phosphohydrolase, HD region K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006515 361.0
TLS2_k127_3590714_4 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 338.0
TLS2_k127_3590714_5 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 312.0
TLS2_k127_3590714_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006897 278.0
TLS2_k127_3590714_7 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000003887 238.0
TLS2_k127_3590714_8 ABC-type phosphate phosphonate transport system permease component K02042 - - 0.000000000000000000000000000000000000000000000000000000000581 220.0
TLS2_k127_3590714_9 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000006546 214.0
TLS2_k127_3597655_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05565,K14086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 584.0
TLS2_k127_3597655_1 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 507.0
TLS2_k127_3597655_10 Na+/H+ ion antiporter subunit K05569 - - 0.0000000000000000000007179 108.0
TLS2_k127_3597655_11 Domain of unknown function (DUF4440) - - - 0.000000000000000001203 90.0
TLS2_k127_3597655_12 Na+/H+ antiporter subunit - - - 0.0000000000000001114 89.0
TLS2_k127_3597655_13 antiporter activity K05570 - - 0.000002361 58.0
TLS2_k127_3597655_14 - - - - 0.00008467 50.0
TLS2_k127_3597655_2 Putative RNA methylase family UPF0020 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 308.0
TLS2_k127_3597655_3 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002309 280.0
TLS2_k127_3597655_4 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000005715 189.0
TLS2_k127_3597655_5 PFAM NADH-ubiquinone oxidoreductase chain 4L K05567 - - 0.000000000000000000000000000000000000003716 149.0
TLS2_k127_3597655_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000009536 145.0
TLS2_k127_3597655_7 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000005271 150.0
TLS2_k127_3597655_8 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000005312 127.0
TLS2_k127_3597655_9 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K05565,K14086 - - 0.00000000000000000000000000001169 124.0
TLS2_k127_3703582_0 Type II/IV secretion system protein K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 299.0
TLS2_k127_3703582_1 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000000000000000000000000000000000000000000000000000002164 249.0
TLS2_k127_3703582_2 PFAM type II secretion system K12511 - - 0.00000000000000000000000000000000000000000000000000000000000005986 224.0
TLS2_k127_3703582_3 Acyltransferase family - - - 0.00000000000000000000000000000000000000000001086 175.0
TLS2_k127_3703582_4 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000000000002714 139.0
TLS2_k127_3703582_5 Protein of unknown function (DUF559) - - - 0.0000000000000000000000002628 110.0
TLS2_k127_3703582_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000006049 107.0
TLS2_k127_3703582_7 oligosaccharyl transferase activity - - - 0.0000000000000000000003312 111.0
TLS2_k127_3703582_8 Histidine kinase - - - 0.000000000000000002256 99.0
TLS2_k127_3703582_9 Flp/Fap pilin component K02651 - - 0.000134 47.0
TLS2_k127_3812519_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 2.61e-293 925.0
TLS2_k127_3812519_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 4.974e-255 801.0
TLS2_k127_3812519_10 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001512 287.0
TLS2_k127_3812519_11 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K14215,K21273 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001888 277.0
TLS2_k127_3812519_12 metal-dependent phosphohydrolase 7TM intracellular region K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008468 275.0
TLS2_k127_3812519_13 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002303 254.0
TLS2_k127_3812519_14 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000001332 253.0
TLS2_k127_3812519_15 Domain of unknown function (DUF4262) - - - 0.00000000000000000000000000000000000000000000000001397 184.0
TLS2_k127_3812519_16 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000001604 195.0
TLS2_k127_3812519_17 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000231 184.0
TLS2_k127_3812519_18 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000006385 188.0
TLS2_k127_3812519_19 SnoaL-like domain - - - 0.00000000000000000000000000000000000000005083 164.0
TLS2_k127_3812519_2 Aminotransferase class-V - - - 3.799e-224 707.0
TLS2_k127_3812519_20 YceI-like domain - - - 0.00000000000000000000000000000000000003082 153.0
TLS2_k127_3812519_21 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0001101,GO:0001666,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0036293,GO:0042221,GO:0044419,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051704,GO:0060255,GO:0065007,GO:0070482,GO:0080090,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000001086 130.0
TLS2_k127_3812519_22 Competence protein ComEA K02237 - - 0.0000000000000000000000000000001678 131.0
TLS2_k127_3812519_23 COG0285 Folylpolyglutamate synthase K00796 - 2.5.1.15 0.000000000000000000000000000001111 132.0
TLS2_k127_3812519_24 dehydratase K01724 - 4.2.1.96 0.000000000000000000000000004947 114.0
TLS2_k127_3812519_25 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000003328 110.0
TLS2_k127_3812519_26 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000000000004728 118.0
TLS2_k127_3812519_27 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000004855 86.0
TLS2_k127_3812519_28 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00000000009358 66.0
TLS2_k127_3812519_29 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.00000004408 65.0
TLS2_k127_3812519_3 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006682 599.0
TLS2_k127_3812519_30 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000001139 62.0
TLS2_k127_3812519_31 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.000006488 57.0
TLS2_k127_3812519_32 Integral membrane protein - - - 0.0008796 48.0
TLS2_k127_3812519_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 359.0
TLS2_k127_3812519_5 PhoH-like protein K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 353.0
TLS2_k127_3812519_6 Dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008853 346.0
TLS2_k127_3812519_7 PFAM Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 332.0
TLS2_k127_3812519_8 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 324.0
TLS2_k127_3812519_9 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 314.0
TLS2_k127_3966867_0 PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 4.135e-210 680.0
TLS2_k127_3966867_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 614.0
TLS2_k127_3966867_10 Proline racemase K01777 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564 5.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 407.0
TLS2_k127_3966867_11 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 390.0
TLS2_k127_3966867_12 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 397.0
TLS2_k127_3966867_13 ABC transporter K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008275 372.0
TLS2_k127_3966867_14 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 351.0
TLS2_k127_3966867_15 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 347.0
TLS2_k127_3966867_16 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007218 339.0
TLS2_k127_3966867_17 Alkylmercury lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 325.0
TLS2_k127_3966867_18 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 325.0
TLS2_k127_3966867_19 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 305.0
TLS2_k127_3966867_2 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 584.0
TLS2_k127_3966867_20 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 301.0
TLS2_k127_3966867_21 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 288.0
TLS2_k127_3966867_22 SMART ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 296.0
TLS2_k127_3966867_23 TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001614 284.0
TLS2_k127_3966867_24 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004432 294.0
TLS2_k127_3966867_25 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002738 278.0
TLS2_k127_3966867_26 associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001079 269.0
TLS2_k127_3966867_27 of an ABC-type transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001892 278.0
TLS2_k127_3966867_28 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001869 260.0
TLS2_k127_3966867_29 Chlorophyllase enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001164 263.0
TLS2_k127_3966867_3 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008512 582.0
TLS2_k127_3966867_30 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002971 252.0
TLS2_k127_3966867_31 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000006663 241.0
TLS2_k127_3966867_32 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000005053 224.0
TLS2_k127_3966867_33 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000001236 218.0
TLS2_k127_3966867_34 PFAM molybdopterin dehydrogenase, FAD-binding K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000005714 224.0
TLS2_k127_3966867_35 Cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000002562 225.0
TLS2_k127_3966867_36 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000009688 215.0
TLS2_k127_3966867_37 SpoU rRNA Methylase family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000003423 198.0
TLS2_k127_3966867_38 permease K05846 - - 0.0000000000000000000000000000000000000000000000000000343 197.0
TLS2_k127_3966867_39 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000003058 192.0
TLS2_k127_3966867_4 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 564.0
TLS2_k127_3966867_40 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000002105 186.0
TLS2_k127_3966867_41 Thiol-disulfide isomerase-like thioredoxin K02199 - - 0.00000000000000000000000000000000000000000000000002406 190.0
TLS2_k127_3966867_42 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000002384 197.0
TLS2_k127_3966867_43 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000001702 182.0
TLS2_k127_3966867_44 Trehalose-phosphatase K01087 - 3.1.3.12 0.00000000000000000000000000000000000000000000001799 181.0
TLS2_k127_3966867_45 ABC transporter (Permease) K05846 - - 0.000000000000000000000000000000000000000000001866 185.0
TLS2_k127_3966867_46 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000002136 180.0
TLS2_k127_3966867_47 Prolyl oligopeptidase family K06889 - - 0.0000000000000000000000000000000000000000002719 170.0
TLS2_k127_3966867_48 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000001227 176.0
TLS2_k127_3966867_49 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000000000000000000003123 160.0
TLS2_k127_3966867_5 synthase K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 503.0
TLS2_k127_3966867_50 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000002212 169.0
TLS2_k127_3966867_51 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000006942 147.0
TLS2_k127_3966867_52 - - - - 0.00000000000000000000000000000000001504 138.0
TLS2_k127_3966867_53 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.000000000000000000000000000000003487 138.0
TLS2_k127_3966867_54 membrane transporter protein K07090 - - 0.0000000000000000000000000000001125 134.0
TLS2_k127_3966867_55 Psort location Cytoplasmic, score 8.87 - - - 0.0000000000000000000000000000001942 136.0
TLS2_k127_3966867_56 PAS domain - - - 0.000000000000000000000000000003897 138.0
TLS2_k127_3966867_57 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000002192 123.0
TLS2_k127_3966867_58 - - - - 0.00000000000000000000000000003141 124.0
TLS2_k127_3966867_59 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000003919 116.0
TLS2_k127_3966867_6 helix_turn_helix, Lux Regulon K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 506.0
TLS2_k127_3966867_60 PspC domain - - - 0.000000000000000000000000005624 128.0
TLS2_k127_3966867_61 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000001048 117.0
TLS2_k127_3966867_62 CAAX protease self-immunity K07052 - - 0.00000000000000000000000006016 118.0
TLS2_k127_3966867_63 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.00000000000000000000000007172 112.0
TLS2_k127_3966867_64 Domain of unknown function (DUF4440) - - - 0.0000000000000000000005414 102.0
TLS2_k127_3966867_66 universal stress protein - - - 0.000000000000000000002533 105.0
TLS2_k127_3966867_67 Protein of unknown function (DUF1232) - - - 0.000000000000000000007812 97.0
TLS2_k127_3966867_68 phosphoglycerate mutase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000002538 102.0
TLS2_k127_3966867_69 - - - - 0.000000000000000005589 90.0
TLS2_k127_3966867_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 481.0
TLS2_k127_3966867_70 C4-type zinc ribbon domain K07164 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000003005 91.0
TLS2_k127_3966867_71 COG4886 Leucine-rich repeat (LRR) protein K13730,K13731 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030260,GO:0030312,GO:0035635,GO:0044403,GO:0044409,GO:0044419,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944 - 0.00000000000000003302 90.0
TLS2_k127_3966867_72 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18958 GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700 - 0.0000000000000000918 85.0
TLS2_k127_3966867_73 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000007969 80.0
TLS2_k127_3966867_74 phosphatidate phosphatase activity - - - 0.000000000000001738 86.0
TLS2_k127_3966867_75 Belongs to the universal stress protein A family - - - 0.000000000000004977 82.0
TLS2_k127_3966867_76 subunit of a heme lyase - - - 0.00000000000001295 85.0
TLS2_k127_3966867_77 May play a role in the intracellular transport of hydrophobic ligands - - - 0.00000000000003386 77.0
TLS2_k127_3966867_78 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000001144 77.0
TLS2_k127_3966867_79 Histidine kinase K07647,K20973 - 2.7.13.3 0.000000000004751 79.0
TLS2_k127_3966867_8 GIY-YIG type nucleases (URI domain) K02342 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007813 433.0
TLS2_k127_3966867_80 membrane - - - 0.0000000001333 68.0
TLS2_k127_3966867_82 - - - - 0.00000006123 56.0
TLS2_k127_3966867_83 PFAM AIG2 family protein - - - 0.0000009386 59.0
TLS2_k127_3966867_84 Parallel beta-helix repeats - - - 0.0000009696 54.0
TLS2_k127_3966867_86 Protein of unknown function (DUF3040) - - - 0.0003898 47.0
TLS2_k127_3966867_87 - - - - 0.0006473 47.0
TLS2_k127_3966867_9 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 418.0
TLS2_k127_3975400_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 6.269e-212 672.0
TLS2_k127_3975400_1 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 472.0
TLS2_k127_4015551_0 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 441.0
TLS2_k127_4015551_1 Evidence 5 No homology to any previously reported sequences - - - 0.00001984 53.0
TLS2_k127_4047325_0 B12 binding domain K00548 - 2.1.1.13 0.0 1281.0
TLS2_k127_4047325_1 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 475.0
TLS2_k127_4047325_10 Immunoglobulin-like domain of bacterial spore germination - - - 0.000000000206 72.0
TLS2_k127_4047325_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 381.0
TLS2_k127_4047325_3 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 293.0
TLS2_k127_4047325_4 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001595 253.0
TLS2_k127_4047325_5 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000000000000000002857 186.0
TLS2_k127_4047325_6 PFAM sugar transferase - - - 0.000000000000000000000000000000000000002446 168.0
TLS2_k127_4047325_7 Uncharacterized protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000002059 139.0
TLS2_k127_4047325_8 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000004146 117.0
TLS2_k127_4047325_9 Peptidase dimerisation domain - - - 0.00000000000000000000429 97.0
TLS2_k127_4050266_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 1.291e-235 741.0
TLS2_k127_4139120_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 7.011e-264 833.0
TLS2_k127_4139120_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 2.054e-202 651.0
TLS2_k127_4139120_10 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005444 395.0
TLS2_k127_4139120_11 Tetrahydrodipicolinate N-succinyltransferase middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 383.0
TLS2_k127_4139120_12 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 382.0
TLS2_k127_4139120_13 Protein of unknown function (DUF2652) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 298.0
TLS2_k127_4139120_14 succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000002255 258.0
TLS2_k127_4139120_15 reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000004331 239.0
TLS2_k127_4139120_16 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.0000000000000000000000000000000000000000000000000000000000000000001957 248.0
TLS2_k127_4139120_17 VanW like protein - - - 0.0000000000000000000000000000000000000000000000000000000000001827 237.0
TLS2_k127_4139120_18 peroxiredoxin activity K03386,K03564,K16922 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000001098 216.0
TLS2_k127_4139120_19 Peptidase C26 - - - 0.00000000000000000000000000000000000000000000000004151 188.0
TLS2_k127_4139120_2 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 569.0
TLS2_k127_4139120_20 YjbR - - - 0.000000000000000000000000000000000001018 153.0
TLS2_k127_4139120_21 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000000001187 119.0
TLS2_k127_4139120_22 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000009182 100.0
TLS2_k127_4139120_23 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.000000000000001385 83.0
TLS2_k127_4139120_24 Endonuclease Exonuclease phosphatase - - - 0.000000000000004615 84.0
TLS2_k127_4139120_25 peptidase inhibitor activity - - - 0.000000000006312 75.0
TLS2_k127_4139120_26 RecB family exonuclease K07465 - - 0.00000002146 64.0
TLS2_k127_4139120_27 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.000001121 61.0
TLS2_k127_4139120_28 cellulose binding - - - 0.000001691 51.0
TLS2_k127_4139120_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007539 550.0
TLS2_k127_4139120_4 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 491.0
TLS2_k127_4139120_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 486.0
TLS2_k127_4139120_6 fumarylacetoacetate (FAA) hydrolase K05921 - 4.1.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 428.0
TLS2_k127_4139120_7 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005547 435.0
TLS2_k127_4139120_8 Inosine-uridine preferring nucleoside hydrolase K01239 GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.2.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 399.0
TLS2_k127_4139120_9 Dipeptidyl aminopeptidase acylaminoacyl peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 406.0
TLS2_k127_4203465_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 6.009e-251 788.0
TLS2_k127_4203465_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.091e-224 716.0
TLS2_k127_4203465_10 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006701 278.0
TLS2_k127_4203465_11 deoxyribose-phosphate aldolase activity K00852,K01619,K01840,K01844 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.1.15,4.1.2.4,5.4.2.8,5.4.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000002852 267.0
TLS2_k127_4203465_12 phenylacetic acid K02611 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000001212 253.0
TLS2_k127_4203465_13 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000001832 229.0
TLS2_k127_4203465_14 Nickel-containing superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000001753 217.0
TLS2_k127_4203465_15 Amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000001815 197.0
TLS2_k127_4203465_16 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000032 198.0
TLS2_k127_4203465_17 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000148 183.0
TLS2_k127_4203465_18 COG0662 Mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000000000000000000435 175.0
TLS2_k127_4203465_19 phenylacetate-CoA oxygenase, PaaJ subunit K02612 GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000008196 179.0
TLS2_k127_4203465_2 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 535.0
TLS2_k127_4203465_20 PFAM Ribose galactose isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000001573 177.0
TLS2_k127_4203465_21 BMC K04027 - - 0.00000000000000000000000000000000001959 137.0
TLS2_k127_4203465_22 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000005178 143.0
TLS2_k127_4203465_23 Phenylacetate-CoA oxygenase K02610 - - 0.00000000000000000000000000000001484 131.0
TLS2_k127_4203465_24 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000004905 133.0
TLS2_k127_4203465_25 BMC - - - 0.00000000000000000000000000001643 127.0
TLS2_k127_4203465_26 Ethanolamine utilisation protein EutN/carboxysome - - - 0.00000000000000000000000000009167 118.0
TLS2_k127_4203465_27 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000002122 121.0
TLS2_k127_4203465_28 Ethanolamine utilisation protein EutN/carboxysome - - - 0.000000000000000000004757 95.0
TLS2_k127_4203465_3 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008783 523.0
TLS2_k127_4203465_30 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000001163 84.0
TLS2_k127_4203465_31 Ethanolamine utilisation protein EutN/carboxysome K04028 - - 0.000000000002743 72.0
TLS2_k127_4203465_32 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000006552 70.0
TLS2_k127_4203465_33 - - - - 0.0000004908 62.0
TLS2_k127_4203465_34 Putative transmembrane protein (PGPGW) - - - 0.000006353 50.0
TLS2_k127_4203465_35 - - - - 0.00005491 55.0
TLS2_k127_4203465_36 - - - - 0.0002874 51.0
TLS2_k127_4203465_4 Aldehyde dehydrogenase family K04021,K13922 GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 481.0
TLS2_k127_4203465_5 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007177 464.0
TLS2_k127_4203465_6 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 442.0
TLS2_k127_4203465_7 argininosuccinate lyase activity K01755,K14681 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 383.0
TLS2_k127_4203465_8 Oxidoreductase FAD-binding domain protein K02613 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 370.0
TLS2_k127_4203465_9 PFAM BMC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 288.0
TLS2_k127_4464919_0 Glucose / Sorbosone dehydrogenase - - - 2.461e-218 706.0
TLS2_k127_4464919_1 COG1404 Subtilisin-like serine proteases K14645 - - 0.0000000000000000000000000000000000000000002192 180.0
TLS2_k127_4464919_2 Leucine rich repeats (6 copies) - - - 0.0000000000000000000000371 115.0
TLS2_k127_4464919_3 pathogenesis - - - 0.00000000000004405 87.0
TLS2_k127_4490997_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 2.683e-230 724.0
TLS2_k127_4490997_1 glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 466.0
TLS2_k127_4490997_10 Lysyl oxidase - - - 0.00000000000000000000000000000000000000000000000001291 192.0
TLS2_k127_4490997_11 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000078 184.0
TLS2_k127_4490997_12 Glycoprotease family K14742 GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000007834 164.0
TLS2_k127_4490997_13 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000001551 131.0
TLS2_k127_4490997_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06925 GO:0008150,GO:0040007 - 0.00000000000000000000000000000003674 135.0
TLS2_k127_4490997_15 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.000000000000000000000000001303 118.0
TLS2_k127_4490997_16 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000002966 94.0
TLS2_k127_4490997_17 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000001559 79.0
TLS2_k127_4490997_19 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000008724 81.0
TLS2_k127_4490997_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K00066 - 1.1.1.132,1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 410.0
TLS2_k127_4490997_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 343.0
TLS2_k127_4490997_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 321.0
TLS2_k127_4490997_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 325.0
TLS2_k127_4490997_6 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008451 278.0
TLS2_k127_4490997_7 PFAM peptidase S58 DmpA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003726 251.0
TLS2_k127_4490997_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000005518 222.0
TLS2_k127_4490997_9 Uracil-DNA glycosylase, family 4 K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000004576 206.0
TLS2_k127_4574158_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 8.692e-255 811.0
TLS2_k127_4574158_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 4.562e-234 741.0
TLS2_k127_4574158_10 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 420.0
TLS2_k127_4574158_11 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 402.0
TLS2_k127_4574158_12 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 368.0
TLS2_k127_4574158_13 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009054 347.0
TLS2_k127_4574158_14 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 335.0
TLS2_k127_4574158_15 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 307.0
TLS2_k127_4574158_16 DNA polymerase III beta subunit K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 291.0
TLS2_k127_4574158_17 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004749 288.0
TLS2_k127_4574158_18 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006147 268.0
TLS2_k127_4574158_19 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001021 279.0
TLS2_k127_4574158_2 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 597.0
TLS2_k127_4574158_20 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000002951 254.0
TLS2_k127_4574158_21 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000001804 244.0
TLS2_k127_4574158_23 alpha-ribazole phosphatase activity K01834,K02226,K15634,K22305 - 3.1.3.3,3.1.3.73,5.4.2.11,5.4.2.12 0.000000000000000000000000000000000000000000000009874 180.0
TLS2_k127_4574158_24 Single-strand binding protein family K03111 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000001188 154.0
TLS2_k127_4574158_25 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000002535 157.0
TLS2_k127_4574158_26 belongs to the sigma-70 factor family, ECF subfamily K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000001151 161.0
TLS2_k127_4574158_27 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000001871 162.0
TLS2_k127_4574158_28 PFAM Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000002374 152.0
TLS2_k127_4574158_29 Cell wall hydrolase autolysin K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.000000000000000000000000000000000006129 149.0
TLS2_k127_4574158_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000416 594.0
TLS2_k127_4574158_30 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000001254 143.0
TLS2_k127_4574158_31 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000004976 139.0
TLS2_k127_4574158_32 Putative single-stranded nucleic acids-binding domain K06346 - - 0.00000000000000000000000000000000135 142.0
TLS2_k127_4574158_33 Membrane protein insertase, YidC Oxa1 family K03217 - - 0.00000000000000000000000000000272 131.0
TLS2_k127_4574158_34 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000002961 126.0
TLS2_k127_4574158_35 belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000115 118.0
TLS2_k127_4574158_36 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000005077 110.0
TLS2_k127_4574158_37 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000006646 102.0
TLS2_k127_4574158_38 SnoaL-like polyketide cyclase - - - 0.00000000000000000001949 100.0
TLS2_k127_4574158_39 PFAM EAL domain protein - - - 0.0000000000000000002294 102.0
TLS2_k127_4574158_4 tRNA nucleotidyltransferase poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009423 487.0
TLS2_k127_4574158_40 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000000287 89.0
TLS2_k127_4574158_41 Bacterial regulatory proteins, tetR family - - - 0.0000000000000002509 86.0
TLS2_k127_4574158_42 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000009013 79.0
TLS2_k127_4574158_43 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000002926 64.0
TLS2_k127_4574158_44 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000002944 69.0
TLS2_k127_4574158_45 protein kinase activity - - - 0.00000000008027 74.0
TLS2_k127_4574158_46 Acetyltransferase K03789 - 2.3.1.128 0.000000001275 70.0
TLS2_k127_4574158_47 Transmembrane domain of unknown function (DUF3566) - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000001214 60.0
TLS2_k127_4574158_48 Protein of unknown function (DUF721) - - - 0.00006128 51.0
TLS2_k127_4574158_5 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 441.0
TLS2_k127_4574158_6 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008523 419.0
TLS2_k127_4574158_7 Pyridine nucleotide-disulphide oxidoreductase K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 405.0
TLS2_k127_4574158_8 Saccharopine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006218 398.0
TLS2_k127_4574158_9 Putative peptidoglycan binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009216 398.0
TLS2_k127_4617277_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1282.0
TLS2_k127_4617277_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.561e-221 715.0
TLS2_k127_4617277_10 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00226,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 0.000000000000000000000000000000000000000000000000000000003981 227.0
TLS2_k127_4617277_11 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000002664 201.0
TLS2_k127_4617277_12 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000009226 194.0
TLS2_k127_4617277_13 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000001697 187.0
TLS2_k127_4617277_14 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000255 132.0
TLS2_k127_4617277_15 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000004259 130.0
TLS2_k127_4617277_16 AAA domain - - - 0.00000000000000000000000000003917 125.0
TLS2_k127_4617277_17 integration host factor - - - 0.00000000000000000000000002201 112.0
TLS2_k127_4617277_18 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000001593 109.0
TLS2_k127_4617277_19 Type IV leader peptidase family K02654 - 3.4.23.43 0.0000000000000000000001375 106.0
TLS2_k127_4617277_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 425.0
TLS2_k127_4617277_20 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000003114 104.0
TLS2_k127_4617277_21 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 GO:0008150,GO:0040007 - 0.0000000000000004637 89.0
TLS2_k127_4617277_22 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000004751 74.0
TLS2_k127_4617277_23 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000007168 48.0
TLS2_k127_4617277_24 Domain of unknown function (DUF4388) - - - 0.0001961 53.0
TLS2_k127_4617277_3 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 377.0
TLS2_k127_4617277_4 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 340.0
TLS2_k127_4617277_5 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008017 325.0
TLS2_k127_4617277_6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008702 274.0
TLS2_k127_4617277_7 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000002511 254.0
TLS2_k127_4617277_8 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000001599 231.0
TLS2_k127_4617277_9 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 GO:0003674,GO:0003700,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 0.000000000000000000000000000000000000000000000000000000001283 206.0
TLS2_k127_4691704_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1571.0
TLS2_k127_4691704_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1550.0
TLS2_k127_4691704_10 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 535.0
TLS2_k127_4691704_100 Transcriptional regulator PadR-like family - - - 0.000000000000005639 81.0
TLS2_k127_4691704_101 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.00000000000004896 78.0
TLS2_k127_4691704_102 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000008242 83.0
TLS2_k127_4691704_103 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000002955 69.0
TLS2_k127_4691704_104 GYD domain - - - 0.0000000008232 61.0
TLS2_k127_4691704_105 - - - - 0.000000001998 65.0
TLS2_k127_4691704_106 - - - - 0.000000003499 66.0
TLS2_k127_4691704_107 Domain of unknown function (DUF2017) - - - 0.00000000704 64.0
TLS2_k127_4691704_108 Domain of unknown function (DUF4388) - - - 0.0000001913 62.0
TLS2_k127_4691704_109 GYD domain - - - 0.00000302 56.0
TLS2_k127_4691704_11 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 498.0
TLS2_k127_4691704_110 Lysylphosphatidylglycerol synthase TM region - - - 0.00003431 55.0
TLS2_k127_4691704_111 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.00005192 53.0
TLS2_k127_4691704_112 - - - - 0.0001533 51.0
TLS2_k127_4691704_12 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003361 471.0
TLS2_k127_4691704_13 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 462.0
TLS2_k127_4691704_14 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 456.0
TLS2_k127_4691704_15 ABC-type Fe3 transport system permease component K02011,K02063 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 462.0
TLS2_k127_4691704_16 Belongs to the thiolase family K00626,K02615 - 2.3.1.174,2.3.1.223,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 455.0
TLS2_k127_4691704_17 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 426.0
TLS2_k127_4691704_18 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 426.0
TLS2_k127_4691704_19 fructose-bisphosphate aldolase, class II, yeast E. coli subtype K01624 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 422.0
TLS2_k127_4691704_2 penicillin amidase K01434 - 3.5.1.11 6.645e-247 787.0
TLS2_k127_4691704_20 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008837 423.0
TLS2_k127_4691704_21 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008448 441.0
TLS2_k127_4691704_22 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 380.0
TLS2_k127_4691704_23 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 368.0
TLS2_k127_4691704_24 PFAM DAHP synthetase I K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 365.0
TLS2_k127_4691704_25 Phosphoserine phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 359.0
TLS2_k127_4691704_26 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005711 353.0
TLS2_k127_4691704_27 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 350.0
TLS2_k127_4691704_28 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 342.0
TLS2_k127_4691704_29 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 348.0
TLS2_k127_4691704_3 4Fe-4S dicluster domain - - - 3.743e-242 769.0
TLS2_k127_4691704_30 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 342.0
TLS2_k127_4691704_31 ABC transporter, periplasmic binding protein, thiB subfamily K02064 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 330.0
TLS2_k127_4691704_32 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 318.0
TLS2_k127_4691704_33 amidohydrolase K01436,K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 317.0
TLS2_k127_4691704_34 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 308.0
TLS2_k127_4691704_35 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 322.0
TLS2_k127_4691704_36 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 303.0
TLS2_k127_4691704_37 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003613 286.0
TLS2_k127_4691704_38 Acetyltransferase (GNAT) domain K00663,K03790 - 2.3.1.128,2.3.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001892 285.0
TLS2_k127_4691704_39 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003104 281.0
TLS2_k127_4691704_4 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - 1.701e-225 714.0
TLS2_k127_4691704_40 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000149 280.0
TLS2_k127_4691704_41 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005531 277.0
TLS2_k127_4691704_42 YibE F family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003528 278.0
TLS2_k127_4691704_43 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008352 269.0
TLS2_k127_4691704_44 3-methyladenine DNA glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000003821 261.0
TLS2_k127_4691704_45 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001416 271.0
TLS2_k127_4691704_46 L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008291 265.0
TLS2_k127_4691704_47 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000003749 257.0
TLS2_k127_4691704_48 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000153 250.0
TLS2_k127_4691704_49 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000213 253.0
TLS2_k127_4691704_5 COG1960 Acyl-CoA dehydrogenases K20035 - - 1.668e-199 638.0
TLS2_k127_4691704_50 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000003996 258.0
TLS2_k127_4691704_51 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000004974 245.0
TLS2_k127_4691704_52 uridine kinase family K00876 - 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000003243 235.0
TLS2_k127_4691704_53 TIGRFAM DNA polymerase LigD, polymerase domain protein K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000004774 251.0
TLS2_k127_4691704_54 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000006353 243.0
TLS2_k127_4691704_55 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000002955 226.0
TLS2_k127_4691704_56 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000000000009643 221.0
TLS2_k127_4691704_57 ATPases associated with a variety of cellular activities K02052,K02062 - - 0.0000000000000000000000000000000000000000000000000000000001565 229.0
TLS2_k127_4691704_58 Sir2 family K12410 - - 0.00000000000000000000000000000000000000000000000000000000181 209.0
TLS2_k127_4691704_59 translation release factor activity - - - 0.00000000000000000000000000000000000000000000000000000002965 211.0
TLS2_k127_4691704_6 Biotin carboxylase C-terminal domain K01959,K01965,K01968 - 6.4.1.1,6.4.1.3,6.4.1.4 7.286e-199 642.0
TLS2_k127_4691704_60 COGs COG1845 Heme copper-type cytochrome quinol oxidase subunit 3 K02276,K02299 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000004472 203.0
TLS2_k127_4691704_61 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000000007475 200.0
TLS2_k127_4691704_62 Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000007623 199.0
TLS2_k127_4691704_63 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000004424 204.0
TLS2_k127_4691704_64 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000001387 197.0
TLS2_k127_4691704_65 PFAM HhH-GPD family protein - - - 0.000000000000000000000000000000000000000000000000000003315 202.0
TLS2_k127_4691704_66 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000002532 189.0
TLS2_k127_4691704_67 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000002266 175.0
TLS2_k127_4691704_68 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000001528 171.0
TLS2_k127_4691704_69 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000004624 180.0
TLS2_k127_4691704_7 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02827 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.12,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008851 601.0
TLS2_k127_4691704_70 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000004279 161.0
TLS2_k127_4691704_71 Putative ATP-dependant zinc protease - - - 0.00000000000000000000000000000000000005414 148.0
TLS2_k127_4691704_72 Aminotransferase K00826 - 2.6.1.42 0.00000000000000000000000000000000001455 148.0
TLS2_k127_4691704_74 DoxX - - - 0.0000000000000000000000000000000005885 140.0
TLS2_k127_4691704_75 ferredoxin K05337 - - 0.0000000000000000000000000000000142 128.0
TLS2_k127_4691704_76 ATP-dependent Clp protease adaptor protein ClpS K06891 - - 0.00000000000000000000000000000003075 128.0
TLS2_k127_4691704_77 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000009433 138.0
TLS2_k127_4691704_78 Helix-turn-helix XRE-family like proteins - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000002059 123.0
TLS2_k127_4691704_79 - - - - 0.00000000000000000000000000000418 132.0
TLS2_k127_4691704_8 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 589.0
TLS2_k127_4691704_80 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000009187 126.0
TLS2_k127_4691704_81 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.00000000000000000000000000001002 125.0
TLS2_k127_4691704_82 Ferredoxin K02230 - 6.6.1.2 0.00000000000000000000000000002969 122.0
TLS2_k127_4691704_83 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000004836 129.0
TLS2_k127_4691704_84 cell redox homeostasis K02199 - - 0.0000000000000000000000000002312 125.0
TLS2_k127_4691704_85 Short-chain dehydrogenase reductase sdr K00046,K00065 - 1.1.1.127,1.1.1.69 0.000000000000000000000000006465 125.0
TLS2_k127_4691704_86 Peptidase family M50 - - - 0.000000000000000000000000007683 128.0
TLS2_k127_4691704_87 COG0655 Multimeric flavodoxin WrbA - - - 0.00000000000000000000000003433 108.0
TLS2_k127_4691704_88 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000002418 111.0
TLS2_k127_4691704_89 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000001367 116.0
TLS2_k127_4691704_9 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 547.0
TLS2_k127_4691704_90 Domain of unknown function (DUF4332) - - - 0.00000000000000000000002901 108.0
TLS2_k127_4691704_91 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000001845 102.0
TLS2_k127_4691704_92 Protein of unknown function (DUF4230) - - - 0.00000000000000000002377 101.0
TLS2_k127_4691704_93 CHASE3 domain - - - 0.0000000000000000003938 100.0
TLS2_k127_4691704_94 translation release factor activity - - - 0.000000000000000000781 98.0
TLS2_k127_4691704_95 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000000001499 89.0
TLS2_k127_4691704_96 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000179 99.0
TLS2_k127_4691704_97 Pfam:DUF385 - - - 0.0000000000000001533 84.0
TLS2_k127_4691704_98 Transcription factor WhiB K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000001108 79.0
TLS2_k127_4691704_99 Protein conserved in bacteria K09790 - - 0.000000000000005211 80.0
TLS2_k127_4725176_0 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 485.0
TLS2_k127_4725176_1 ATPases associated with a variety of cellular activities K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 447.0
TLS2_k127_4725176_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 358.0
TLS2_k127_4725176_3 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 308.0
TLS2_k127_4725176_4 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000001977 234.0
TLS2_k127_4725176_5 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000002521 215.0
TLS2_k127_4725176_6 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000001838 193.0
TLS2_k127_4725176_7 Trypsin K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000002387 187.0
TLS2_k127_4725176_8 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000001888 76.0
TLS2_k127_4725176_9 ABC-type sugar transport system, permease component K02026 - - 0.00000000000142 75.0
TLS2_k127_4726889_0 xanthine dehydrogenase activity K03520 - 1.2.5.3 0.0 1440.0
TLS2_k127_4726889_1 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 0.0 1316.0
TLS2_k127_4726889_10 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 411.0
TLS2_k127_4726889_11 Dehydrogenase K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 376.0
TLS2_k127_4726889_12 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 369.0
TLS2_k127_4726889_13 COG0714 MoxR-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 355.0
TLS2_k127_4726889_14 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 352.0
TLS2_k127_4726889_15 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 327.0
TLS2_k127_4726889_16 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 323.0
TLS2_k127_4726889_17 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 330.0
TLS2_k127_4726889_18 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 293.0
TLS2_k127_4726889_19 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 298.0
TLS2_k127_4726889_2 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 3.499e-274 871.0
TLS2_k127_4726889_20 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006113 283.0
TLS2_k127_4726889_21 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000002719 267.0
TLS2_k127_4726889_22 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001923 264.0
TLS2_k127_4726889_23 Protein containing von Willebrand factor type A (vWA) domain K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001333 262.0
TLS2_k127_4726889_24 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000805 240.0
TLS2_k127_4726889_25 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002354 224.0
TLS2_k127_4726889_26 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.0000000000000000000000000000000000000000000000000000000000000009781 225.0
TLS2_k127_4726889_27 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000276 214.0
TLS2_k127_4726889_28 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000001391 212.0
TLS2_k127_4726889_29 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000001254 203.0
TLS2_k127_4726889_3 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 624.0
TLS2_k127_4726889_30 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000001085 196.0
TLS2_k127_4726889_31 carboxylic ester hydrolase activity K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000001933 192.0
TLS2_k127_4726889_32 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.000000000000000000000000000000000000000000011 166.0
TLS2_k127_4726889_33 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000005834 175.0
TLS2_k127_4726889_34 - - - - 0.00000000000000000000000000000000000000009141 154.0
TLS2_k127_4726889_35 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000003937 138.0
TLS2_k127_4726889_36 XdhC and CoxI family - - - 0.00000000000000000000000000000009605 131.0
TLS2_k127_4726889_37 - - - - 0.0000000000000000000000000000002002 124.0
TLS2_k127_4726889_38 Methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000005156 134.0
TLS2_k127_4726889_39 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000000000001697 118.0
TLS2_k127_4726889_4 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 560.0
TLS2_k127_4726889_40 - - - - 0.00000000000000000000000002658 109.0
TLS2_k127_4726889_41 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000006488 109.0
TLS2_k127_4726889_42 - - - - 0.000000000000000000000001165 110.0
TLS2_k127_4726889_43 - - - - 0.000000000000000000000153 100.0
TLS2_k127_4726889_45 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000002948 101.0
TLS2_k127_4726889_46 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.00000000000000000008852 96.0
TLS2_k127_4726889_47 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000007832 84.0
TLS2_k127_4726889_48 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000001931 83.0
TLS2_k127_4726889_49 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000002388 85.0
TLS2_k127_4726889_5 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 522.0
TLS2_k127_4726889_51 pathogenesis - - - 0.0000000000002656 80.0
TLS2_k127_4726889_54 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - 0.000000002808 68.0
TLS2_k127_4726889_55 - - - - 0.00000001733 60.0
TLS2_k127_4726889_56 Cold shock K03704 - - 0.0000001598 59.0
TLS2_k127_4726889_6 NAT, N-acetyltransferase, of N-acetylglutamate synthase K22478 - 2.3.1.1,2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 493.0
TLS2_k127_4726889_7 Belongs to the ATCase OTCase family K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 473.0
TLS2_k127_4726889_8 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 438.0
TLS2_k127_4726889_9 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 439.0
TLS2_k127_4811486_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 502.0
TLS2_k127_4811486_1 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000005868 256.0
TLS2_k127_4853635_0 E1-E2 ATPase K12952 - - 5.015e-230 741.0
TLS2_k127_4853635_1 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008302 467.0
TLS2_k127_4853635_10 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002861 295.0
TLS2_k127_4853635_11 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001381 271.0
TLS2_k127_4853635_12 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003493 267.0
TLS2_k127_4853635_13 PFAM PHP domain K07053,K20859 - 3.1.3.97,3.1.4.57 0.00000000000000000000000000000000000000000000000000000000000000000000000721 252.0
TLS2_k127_4853635_14 Ami_3 K01448 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000001266 234.0
TLS2_k127_4853635_15 - - - - 0.00000000000000000000000000000000000004608 147.0
TLS2_k127_4853635_16 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000004707 144.0
TLS2_k127_4853635_17 deaminase K01485 - 3.5.4.1 0.0000000000000000000000000000000000005882 141.0
TLS2_k127_4853635_18 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.0000000000000000000000000000000000006936 149.0
TLS2_k127_4853635_19 - - - - 0.00000000000000000000000000000003156 136.0
TLS2_k127_4853635_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 437.0
TLS2_k127_4853635_20 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000004257 102.0
TLS2_k127_4853635_21 - K01992 - - 0.000000000000000000001229 109.0
TLS2_k127_4853635_23 SnoaL-like domain - - - 0.000000000005369 71.0
TLS2_k127_4853635_24 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000008349 65.0
TLS2_k127_4853635_25 PFAM filamentation induced by cAMP protein Fic - - - 0.00001815 49.0
TLS2_k127_4853635_26 Belongs to the 'phage' integrase family - - - 0.0003341 44.0
TLS2_k127_4853635_3 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 378.0
TLS2_k127_4853635_4 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 367.0
TLS2_k127_4853635_5 Belongs to the serpin family K13963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 361.0
TLS2_k127_4853635_6 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 319.0
TLS2_k127_4853635_7 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 314.0
TLS2_k127_4853635_8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 319.0
TLS2_k127_4853635_9 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 316.0
TLS2_k127_4917224_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K03520 - 1.2.5.3 7.124e-218 700.0
TLS2_k127_4917224_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 487.0
TLS2_k127_4917224_2 Aminotransferase class I and II K11358 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 417.0
TLS2_k127_4917224_3 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003683 261.0
TLS2_k127_4917224_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000002534 103.0
TLS2_k127_4917224_5 Thioesterase superfamily - - - 0.00000000000000000004786 96.0
TLS2_k127_5012018_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 536.0
TLS2_k127_5012018_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 543.0
TLS2_k127_5012018_10 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000882 169.0
TLS2_k127_5012018_11 Riboflavin synthase subunit alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000006572 169.0
TLS2_k127_5012018_12 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.0000000000000000000000000000000000000000001375 166.0
TLS2_k127_5012018_13 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000000000000004243 160.0
TLS2_k127_5012018_14 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000000008962 131.0
TLS2_k127_5012018_15 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000001666 111.0
TLS2_k127_5012018_16 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000004975 76.0
TLS2_k127_5012018_17 - - - - 0.0000002746 53.0
TLS2_k127_5012018_18 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.0001608 55.0
TLS2_k127_5012018_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 380.0
TLS2_k127_5012018_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 352.0
TLS2_k127_5012018_4 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 303.0
TLS2_k127_5012018_5 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0034641,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000001968 272.0
TLS2_k127_5012018_6 PFAM Ribulose-phosphate 3-epimerase K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000002205 222.0
TLS2_k127_5012018_7 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000001018 221.0
TLS2_k127_5012018_8 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000001206 209.0
TLS2_k127_5012018_9 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000002942 193.0
TLS2_k127_510420_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 1.855e-218 709.0
TLS2_k127_510420_1 pilus assembly protein ATPase CpaF K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 574.0
TLS2_k127_510420_2 Ribosomal protein S1 K02945 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 466.0
TLS2_k127_510420_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006 432.0
TLS2_k127_510420_4 NUBPL iron-transfer P-loop NTPase K02282 - - 0.000000000000000000000000000000000000000000000000000000000001715 224.0
TLS2_k127_510420_5 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000000001025 175.0
TLS2_k127_510420_6 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000001835 132.0
TLS2_k127_510420_7 SAF K02279 - - 0.000000007555 67.0
TLS2_k127_5250187_0 TrkA-C domain - - - 5.733e-306 956.0
TLS2_k127_5250187_1 helicase superfamily c-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007674 427.0
TLS2_k127_5250187_2 Signal transduction histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000008247 125.0
TLS2_k127_5250187_3 Pfam:Pyridox_oxidase - - - 0.0000000000000000008601 92.0
TLS2_k127_5250187_4 regulator of chromosome condensation, RCC1 K12287 - - 0.0000000001737 72.0
TLS2_k127_5260667_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.803e-255 797.0
TLS2_k127_5260667_1 COG2059 Chromate transport protein ChrA K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 506.0
TLS2_k127_5260667_10 phosphorylase K03784 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 313.0
TLS2_k127_5260667_11 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 298.0
TLS2_k127_5260667_12 Short-chain Dehydrogenase reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 296.0
TLS2_k127_5260667_13 ABC-2 family transporter protein K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 302.0
TLS2_k127_5260667_14 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003023 286.0
TLS2_k127_5260667_15 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001003 273.0
TLS2_k127_5260667_16 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000538 242.0
TLS2_k127_5260667_18 AzlC protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001154 228.0
TLS2_k127_5260667_19 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000003713 222.0
TLS2_k127_5260667_2 Permease family K06901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 457.0
TLS2_k127_5260667_20 - - - - 0.000000000000000000000000000000000000000000000000000000000144 205.0
TLS2_k127_5260667_21 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000001862 220.0
TLS2_k127_5260667_22 Arginase family - - - 0.0000000000000000000000000000000000000000000000000000001655 205.0
TLS2_k127_5260667_23 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000001806 197.0
TLS2_k127_5260667_24 MOSC domain - - - 0.00000000000000000000000000000000000000000000000000003846 191.0
TLS2_k127_5260667_25 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000002726 194.0
TLS2_k127_5260667_26 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000001797 190.0
TLS2_k127_5260667_27 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000004331 190.0
TLS2_k127_5260667_28 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000006199 173.0
TLS2_k127_5260667_29 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000002074 173.0
TLS2_k127_5260667_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007944 433.0
TLS2_k127_5260667_30 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - 0.00000000000000000000000000000000000000000003327 170.0
TLS2_k127_5260667_31 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000006735 164.0
TLS2_k127_5260667_32 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000046 163.0
TLS2_k127_5260667_33 Amidohydrolase family - - - 0.0000000000000000000000000000000000000207 158.0
TLS2_k127_5260667_34 - - - - 0.00000000000000000000000000000000000004602 156.0
TLS2_k127_5260667_35 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.00000000000000000000000000000000000004817 159.0
TLS2_k127_5260667_36 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000001293 148.0
TLS2_k127_5260667_37 Thioesterase superfamily - - - 0.000000000000000000000000001614 127.0
TLS2_k127_5260667_38 transcriptional - - - 0.000000000000000000000000004885 113.0
TLS2_k127_5260667_39 transcriptional regulator - - - 0.000000000000000000000001541 108.0
TLS2_k127_5260667_4 ABC transporter K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004513 418.0
TLS2_k127_5260667_40 Nitroreductase family - - - 0.0000000000000000000001032 106.0
TLS2_k127_5260667_41 Clp amino terminal domain, pathogenicity island component K03696 - - 0.0000000000000000000007647 106.0
TLS2_k127_5260667_42 Acetyltransferase (GNAT) domain - - - 0.000000000000000000005859 103.0
TLS2_k127_5260667_43 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.00000000000000000001801 105.0
TLS2_k127_5260667_44 SnoaL-like domain - - - 0.000000000000000002762 89.0
TLS2_k127_5260667_45 - - - - 0.000000000000000005056 85.0
TLS2_k127_5260667_46 - - - - 0.00000000000000001946 89.0
TLS2_k127_5260667_47 - - - - 0.0000000000000005907 86.0
TLS2_k127_5260667_48 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.000000000000001021 87.0
TLS2_k127_5260667_49 Branched-chain amino acid transport protein (AzlD) - - - 0.000000000000007457 85.0
TLS2_k127_5260667_5 Homoserine dehydrogenase K00003,K12524 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 389.0
TLS2_k127_5260667_50 - - - - 0.0000000000003169 76.0
TLS2_k127_5260667_51 Sigma-70, region 4 - - - 0.000000000001748 73.0
TLS2_k127_5260667_52 - - - - 0.00000000003089 70.0
TLS2_k127_5260667_53 ABC-2 family transporter protein K01992 - - 0.000000007051 67.0
TLS2_k127_5260667_54 Universal stress protein family - - - 0.0000001808 62.0
TLS2_k127_5260667_55 - - - - 0.000002759 55.0
TLS2_k127_5260667_56 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.000003604 59.0
TLS2_k127_5260667_57 Activator of hsp90 atpase 1 family protein - - - 0.00003051 52.0
TLS2_k127_5260667_58 Serine aminopeptidase, S33 - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0004217 42.0
TLS2_k127_5260667_6 membrane protein terC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 379.0
TLS2_k127_5260667_7 DNA primase, small subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 349.0
TLS2_k127_5260667_8 ATP dependent DNA ligase domain - GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 344.0
TLS2_k127_5260667_9 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 343.0
TLS2_k127_5260742_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 515.0
TLS2_k127_5260742_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 499.0
TLS2_k127_5260742_2 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.000000000000000000000000000000000000000009788 160.0
TLS2_k127_5260742_4 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000004407 101.0
TLS2_k127_5260742_5 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000749 93.0
TLS2_k127_5260742_6 Putative adhesin - - - 0.00000000000000001234 96.0
TLS2_k127_5260742_7 - - - - 0.0000000000003486 77.0
TLS2_k127_5260742_8 Belongs to the UPF0109 family K06960 GO:0008150,GO:0040007 - 0.000000000666 63.0
TLS2_k127_5260742_9 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000001378 59.0
TLS2_k127_5363155_0 SMART Adenylyl cyclase class-3 4 guanylyl cyclase - - - 7.417e-195 645.0
TLS2_k127_5363155_1 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 301.0
TLS2_k127_5363155_2 Protein of unknown function (DUF445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004796 282.0
TLS2_k127_5363155_3 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003655 249.0
TLS2_k127_5363155_4 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000001582 183.0
TLS2_k127_5363155_5 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000004059 166.0
TLS2_k127_5363155_6 Tetratricopeptide repeat - - - 0.000000000000000000000001164 119.0
TLS2_k127_5363155_7 lactoylglutathione lyase activity - - - 0.00000000000000000000000609 106.0
TLS2_k127_5363155_8 AAA domain - - - 0.0000005599 60.0
TLS2_k127_5400591_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 7.486e-289 919.0
TLS2_k127_5400591_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 9.114e-216 681.0
TLS2_k127_5400591_10 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 361.0
TLS2_k127_5400591_11 Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 317.0
TLS2_k127_5400591_12 Arginase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 299.0
TLS2_k127_5400591_13 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004862 279.0
TLS2_k127_5400591_14 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000002692 258.0
TLS2_k127_5400591_15 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000003095 250.0
TLS2_k127_5400591_16 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000002854 239.0
TLS2_k127_5400591_17 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000212 209.0
TLS2_k127_5400591_18 PAC2 family - - - 0.000000000000000000000000000000000000000000000000000002177 201.0
TLS2_k127_5400591_19 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000002218 187.0
TLS2_k127_5400591_2 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K05565,K14086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006343 602.0
TLS2_k127_5400591_20 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000001009 196.0
TLS2_k127_5400591_21 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000004347 171.0
TLS2_k127_5400591_22 PFAM NADH-ubiquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000000000000000004212 159.0
TLS2_k127_5400591_23 Iron-storage protein K02217 - 1.16.3.2 0.000000000000000000000000000000000005576 144.0
TLS2_k127_5400591_24 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000009869 135.0
TLS2_k127_5400591_25 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.00000000000000000000000000000006616 135.0
TLS2_k127_5400591_26 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000001722 126.0
TLS2_k127_5400591_27 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K05565,K14086 - - 0.00000000000000000000000000004981 130.0
TLS2_k127_5400591_28 - - - - 0.00000000000000000000000001279 123.0
TLS2_k127_5400591_29 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000000000002586 113.0
TLS2_k127_5400591_3 Proton-conducting membrane transporter K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 535.0
TLS2_k127_5400591_30 multisubunit Na H antiporter MnhE subunit K05569 - - 0.000000000000000000000002446 118.0
TLS2_k127_5400591_31 Na+/H+ antiporter subunit - - - 0.000000000000000000003687 97.0
TLS2_k127_5400591_32 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000002437 90.0
TLS2_k127_5400591_33 - - - - 0.00000000000000399 85.0
TLS2_k127_5400591_34 toxin-antitoxin pair type II binding - - - 0.0000000000001 74.0
TLS2_k127_5400591_35 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000002298 79.0
TLS2_k127_5400591_36 antiporter activity K05570 - - 0.0000003328 58.0
TLS2_k127_5400591_38 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00001217 53.0
TLS2_k127_5400591_39 Allantoicase K01477,K01483 GO:0000050,GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0004037,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0017144,GO:0019627,GO:0034641,GO:0042737,GO:0043603,GO:0043604,GO:0043605,GO:0044237,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046483,GO:0046700,GO:0071704,GO:0071941,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.3.4,4.3.2.3 0.00002868 47.0
TLS2_k127_5400591_4 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 524.0
TLS2_k127_5400591_40 - - - - 0.0002544 44.0
TLS2_k127_5400591_5 Thimet oligopeptidase K01392,K01393 GO:0000209,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0016567,GO:0016787,GO:0019538,GO:0023052,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032446,GO:0033218,GO:0034641,GO:0035556,GO:0036211,GO:0042277,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0070013,GO:0070647,GO:0071704,GO:0140096,GO:1901564 3.4.24.15,3.4.24.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 463.0
TLS2_k127_5400591_6 allantoinase K01466 - 3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 437.0
TLS2_k127_5400591_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 434.0
TLS2_k127_5400591_8 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 432.0
TLS2_k127_5400591_9 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 432.0
TLS2_k127_559178_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 1.426e-308 968.0
TLS2_k127_559178_1 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 2.407e-218 688.0
TLS2_k127_559178_10 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000001185 262.0
TLS2_k127_559178_11 F420-0:Gamma-glutamyl ligase K12234 GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000002867 233.0
TLS2_k127_559178_12 TIGRFAM bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000005889 211.0
TLS2_k127_559178_13 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000001288 181.0
TLS2_k127_559178_14 LytR cell envelope-related transcriptional attenuator - - - 0.00000000000000000000000000000000000000000000001967 188.0
TLS2_k127_559178_15 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000006372 173.0
TLS2_k127_559178_16 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000002075 155.0
TLS2_k127_559178_17 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000005613 130.0
TLS2_k127_559178_18 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000004522 127.0
TLS2_k127_559178_19 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000000000000002143 106.0
TLS2_k127_559178_2 Biotin carboxylase, N-terminal domain K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 557.0
TLS2_k127_559178_20 23S rRNA-intervening sequence protein - - - 0.0000000000000000000004096 100.0
TLS2_k127_559178_21 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000009541 106.0
TLS2_k127_559178_22 - - - - 0.0000000000003006 76.0
TLS2_k127_559178_23 Trm112p-like protein K09791 - - 0.000000000008962 70.0
TLS2_k127_559178_24 - - - - 0.000000000192 67.0
TLS2_k127_559178_25 - - - - 0.000001447 61.0
TLS2_k127_559178_27 Phosphoribosyl transferase domain - - - 0.000004496 55.0
TLS2_k127_559178_28 - - - - 0.000009408 54.0
TLS2_k127_559178_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 522.0
TLS2_k127_559178_4 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 451.0
TLS2_k127_559178_5 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 437.0
TLS2_k127_559178_6 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 408.0
TLS2_k127_559178_7 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007058 406.0
TLS2_k127_559178_8 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008886 383.0
TLS2_k127_559178_9 ATPases associated with a variety of cellular activities K09812 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 314.0
TLS2_k127_5638118_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 6.062e-242 772.0
TLS2_k127_5638118_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 4.319e-216 689.0
TLS2_k127_5638118_10 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000006896 131.0
TLS2_k127_5638118_11 Transcriptional regulatory protein, C terminal K07658 - - 0.0000000000000000000006325 100.0
TLS2_k127_5638118_12 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000001254 91.0
TLS2_k127_5638118_13 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000001359 82.0
TLS2_k127_5638118_14 Protein of unknown function (DUF503) - - - 0.0000000008608 67.0
TLS2_k127_5638118_15 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000002 63.0
TLS2_k127_5638118_16 HNH nucleases K07451 - - 0.00001091 48.0
TLS2_k127_5638118_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 618.0
TLS2_k127_5638118_3 alcohol dehydrogenase K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 415.0
TLS2_k127_5638118_4 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 379.0
TLS2_k127_5638118_5 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 372.0
TLS2_k127_5638118_6 Glycosyl transferase family 21 K11936 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 368.0
TLS2_k127_5638118_7 DHH family K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005875 283.0
TLS2_k127_5638118_8 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000001037 246.0
TLS2_k127_5638118_9 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000001121 225.0
TLS2_k127_5644255_0 4Fe-4S single cluster domain K06937 - - 8.295e-227 715.0
TLS2_k127_5644255_1 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008699 467.0
TLS2_k127_5644255_10 31 kDa ribonucleoprotein K11294 GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0009266,GO:0009409,GO:0009451,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009628,GO:0009631,GO:0009892,GO:0009894,GO:0009895,GO:0009941,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010608,GO:0016020,GO:0016070,GO:0016553,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034357,GO:0034641,GO:0042651,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043487,GO:0043489,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0055035,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902369 - 0.0000000000000000000000044 106.0
TLS2_k127_5644255_11 Protein of unknown function (DUF2905) - - - 0.0000000000000001869 81.0
TLS2_k127_5644255_12 - - - - 0.000000000000000466 85.0
TLS2_k127_5644255_14 Membrane - - - 0.00000007716 64.0
TLS2_k127_5644255_15 Polyketide cyclase / dehydrase and lipid transport - - - 0.000007811 56.0
TLS2_k127_5644255_2 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 384.0
TLS2_k127_5644255_3 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 374.0
TLS2_k127_5644255_4 Acetoacetate decarboxylase (ADC) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 348.0
TLS2_k127_5644255_5 lipoprotein biosynthetic process K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000009772 243.0
TLS2_k127_5644255_6 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000005584 239.0
TLS2_k127_5644255_7 PFAM Rhomboid family - - - 0.0000000000000000000000000000000000000000004205 166.0
TLS2_k127_5644255_8 sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000843 152.0
TLS2_k127_5644255_9 histidine kinase A domain protein - - - 0.000000000000000000000000000117 132.0
TLS2_k127_5658087_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 1.468e-231 738.0
TLS2_k127_5658087_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 613.0
TLS2_k127_5658087_10 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 340.0
TLS2_k127_5658087_11 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001375 276.0
TLS2_k127_5658087_12 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001047 270.0
TLS2_k127_5658087_13 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002159 261.0
TLS2_k127_5658087_14 mitochondrial respiratory chain complex I assembly K18166 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001477 254.0
TLS2_k127_5658087_15 pfkB family carbohydrate kinase K00882 - 2.7.1.56 0.0000000000000000000000000000000000000000000000000000000000000000000002649 248.0
TLS2_k127_5658087_16 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000001796 254.0
TLS2_k127_5658087_17 cell wall organization K10541,K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000228 243.0
TLS2_k127_5658087_18 PDZ DHR GLGF domain protein K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000003617 214.0
TLS2_k127_5658087_19 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000008346 204.0
TLS2_k127_5658087_2 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 569.0
TLS2_k127_5658087_20 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000000000007945 195.0
TLS2_k127_5658087_21 PFAM ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000003424 196.0
TLS2_k127_5658087_22 Belongs to the peptidase S16 family K07177 - - 0.000000000000000000000000000000000000000000000000002094 195.0
TLS2_k127_5658087_23 Sigma-70 region 3 K03090 GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000003304 192.0
TLS2_k127_5658087_24 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000004101 186.0
TLS2_k127_5658087_25 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000008803 176.0
TLS2_k127_5658087_26 Redoxin K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000000000000000000000000000000000000001222 157.0
TLS2_k127_5658087_27 protein phosphatase 2C domain protein K04757 - 2.7.11.1 0.0000000000000000000000000000000000000003123 172.0
TLS2_k127_5658087_28 Survival protein SurE K03787 - 3.1.3.5 0.000000000000000000000000000000000000001384 162.0
TLS2_k127_5658087_29 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000004341 150.0
TLS2_k127_5658087_3 oxidoreductase K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 536.0
TLS2_k127_5658087_30 PRC-barrel domain - - - 0.00000000000000000000000000000000001303 140.0
TLS2_k127_5658087_31 MoaE protein K21142 - 2.8.1.12 0.00000000000000000000000000003493 122.0
TLS2_k127_5658087_32 Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - 0.0000000000000000000000000004406 118.0
TLS2_k127_5658087_33 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000325 109.0
TLS2_k127_5658087_35 Zincin-like metallopeptidase - - - 0.0000000000000000000094 104.0
TLS2_k127_5658087_36 sigma factor antagonist activity K04757 - 2.7.11.1 0.00000000000000000002476 100.0
TLS2_k127_5658087_37 protein phosphatase 2C domain protein - - - 0.0000000000000000001182 94.0
TLS2_k127_5658087_38 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000001482 91.0
TLS2_k127_5658087_39 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000003113 83.0
TLS2_k127_5658087_4 COG0659 Sulfate permease and related transporters (MFS superfamily) K01673,K03321 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 499.0
TLS2_k127_5658087_40 Bacterial antitoxin of type II TA system, VapB - GO:0006417,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045727,GO:0045927,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:2000112 - 0.0000000000000006538 79.0
TLS2_k127_5658087_41 glyoxalase III activity - - - 0.0000000000005724 75.0
TLS2_k127_5658087_42 STAS domain K06378 - - 0.00000000009383 72.0
TLS2_k127_5658087_43 Belongs to the anti-sigma-factor antagonist family - - - 0.0000000007374 69.0
TLS2_k127_5658087_44 SnoaL-like domain K06893 - - 0.000000000791 66.0
TLS2_k127_5658087_45 lactoylglutathione lyase activity - - - 0.000000003703 63.0
TLS2_k127_5658087_46 Recombinase - - - 0.00000001203 56.0
TLS2_k127_5658087_47 - - - - 0.00000001476 65.0
TLS2_k127_5658087_48 - - - - 0.00000002132 58.0
TLS2_k127_5658087_49 - - - - 0.0000001213 62.0
TLS2_k127_5658087_5 Kynurenine--oxoglutarate transaminase - GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 443.0
TLS2_k127_5658087_51 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000009014 58.0
TLS2_k127_5658087_52 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000007889 54.0
TLS2_k127_5658087_53 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00004552 50.0
TLS2_k127_5658087_6 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009848 437.0
TLS2_k127_5658087_7 Bacterial transcriptional activator domain - GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006355,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019538,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0080090,GO:0090407,GO:0097159,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 416.0
TLS2_k127_5658087_8 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 353.0
TLS2_k127_5658087_9 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00651 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 336.0
TLS2_k127_5872238_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 1.167e-279 877.0
TLS2_k127_5872238_1 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 5.226e-227 717.0
TLS2_k127_5872238_10 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000839 109.0
TLS2_k127_5872238_11 RDD family - - - 0.000000002673 68.0
TLS2_k127_5872238_2 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 9.19e-221 698.0
TLS2_k127_5872238_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 4.964e-195 618.0
TLS2_k127_5872238_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 464.0
TLS2_k127_5872238_5 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 451.0
TLS2_k127_5872238_6 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 441.0
TLS2_k127_5872238_7 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 344.0
TLS2_k127_5872238_8 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 330.0
TLS2_k127_5872238_9 TIGRFAM Acetolactate synthase, small subunit K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.000000000000000000000000000000000000000001248 165.0
TLS2_k127_5893720_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 298.0
TLS2_k127_5893720_1 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000002565 165.0
TLS2_k127_5893720_2 RibD C-terminal domain K00082 - 1.1.1.193 0.00000000000000000000000000000000004719 145.0
TLS2_k127_6002411_0 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 525.0
TLS2_k127_6002411_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 454.0
TLS2_k127_6002411_10 Ferric uptake regulator family K03711 - - 0.000000000000000000000000002976 116.0
TLS2_k127_6002411_2 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 448.0
TLS2_k127_6002411_3 COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component K02031,K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 425.0
TLS2_k127_6002411_4 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008932 394.0
TLS2_k127_6002411_5 PFAM Aminotransferase class I and II K00842,K14155 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 336.0
TLS2_k127_6002411_6 ABC 3 transport family K02075,K09819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 301.0
TLS2_k127_6002411_7 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006187 285.0
TLS2_k127_6002411_8 Peptidase, M20 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000431 273.0
TLS2_k127_6002411_9 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.00000000000000000000000000000000000000000000000000000000000001647 227.0
TLS2_k127_6028383_0 acyl-CoA dehydrogenase K09456 - - 1.903e-196 631.0
TLS2_k127_6028383_1 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 534.0
TLS2_k127_6028383_10 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007713 332.0
TLS2_k127_6028383_11 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 323.0
TLS2_k127_6028383_12 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 317.0
TLS2_k127_6028383_13 Part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 311.0
TLS2_k127_6028383_14 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 309.0
TLS2_k127_6028383_15 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001762 282.0
TLS2_k127_6028383_16 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001492 268.0
TLS2_k127_6028383_17 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000009531 248.0
TLS2_k127_6028383_18 Cobalt ABC transporter K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000184 231.0
TLS2_k127_6028383_19 Helix-turn-helix diphteria tox regulatory element K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000001512 213.0
TLS2_k127_6028383_2 Exporter of polyketide K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 467.0
TLS2_k127_6028383_20 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.00000000000000000000000000000000000000000000000000000008794 198.0
TLS2_k127_6028383_21 Major facilitator Superfamily K07552,K19577 - - 0.000000000000000000000000000000000000000000000000000009349 209.0
TLS2_k127_6028383_22 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000008375 136.0
TLS2_k127_6028383_23 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000376 137.0
TLS2_k127_6028383_24 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000001468 109.0
TLS2_k127_6028383_25 Belongs to the Fur family K03711 - - 0.000000000000000000005233 98.0
TLS2_k127_6028383_26 Beta-lactamase superfamily domain - - - 0.00000000000000001698 91.0
TLS2_k127_6028383_3 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 462.0
TLS2_k127_6028383_4 ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 442.0
TLS2_k127_6028383_5 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 445.0
TLS2_k127_6028383_6 Daunorubicin resistance ABC transporter ATP-binding subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 422.0
TLS2_k127_6028383_7 transport, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 373.0
TLS2_k127_6028383_8 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003953 363.0
TLS2_k127_6028383_9 binding-protein-dependent transport systems inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 359.0
TLS2_k127_6054602_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 4.281e-273 854.0
TLS2_k127_6229847_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 3.624e-207 662.0
TLS2_k127_6229847_1 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 505.0
TLS2_k127_6229847_10 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000004773 214.0
TLS2_k127_6229847_11 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000111 211.0
TLS2_k127_6229847_12 sugar transferase - - - 0.00000000000000000000000000000000000000000000000000001748 196.0
TLS2_k127_6229847_13 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000001735 156.0
TLS2_k127_6229847_14 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000001189 124.0
TLS2_k127_6229847_15 - - - - 0.000008244 55.0
TLS2_k127_6229847_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 378.0
TLS2_k127_6229847_3 UDP-N-acetylglucosamine 2-epimerase activity K01791,K13019 - 5.1.3.14,5.1.3.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 352.0
TLS2_k127_6229847_4 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 340.0
TLS2_k127_6229847_5 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 316.0
TLS2_k127_6229847_7 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 317.0
TLS2_k127_6229847_8 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001669 254.0
TLS2_k127_6229847_9 methyltransferase K16215 - 2.1.1.243 0.000000000000000000000000000000000000000000000000000000000000009628 222.0
TLS2_k127_627218_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 1.576e-232 738.0
TLS2_k127_627218_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 580.0
TLS2_k127_627218_10 Binding-protein-dependent transport system inner membrane component K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 352.0
TLS2_k127_627218_11 Binding-protein-dependent transport system inner membrane component K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 350.0
TLS2_k127_627218_12 Bacterial periplasmic substrate-binding proteins K02030,K10005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 347.0
TLS2_k127_627218_13 isochorismatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 318.0
TLS2_k127_627218_14 Response regulator receiver K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002715 259.0
TLS2_k127_627218_15 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005167 269.0
TLS2_k127_627218_16 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000002056 251.0
TLS2_k127_627218_17 Binding-protein-dependent transport system inner membrane component K09970 - - 0.0000000000000000000000000000000000000000000000000000000000000000002109 244.0
TLS2_k127_627218_18 enzyme of poly-gamma-glutamate biosynthesis (Capsule formation) K07282 - - 0.000000000000000000000000000000000000000000000008038 185.0
TLS2_k127_627218_19 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000004332 158.0
TLS2_k127_627218_2 glutamine synthetase K01915 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006167 537.0
TLS2_k127_627218_20 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000408 146.0
TLS2_k127_627218_21 ABC transporter, ATP-binding protein K02028 - 3.6.3.21 0.000000000000000000000000000001759 121.0
TLS2_k127_627218_22 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000217 89.0
TLS2_k127_627218_23 Transcriptional regulator - - - 0.00000000001975 72.0
TLS2_k127_627218_3 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 440.0
TLS2_k127_627218_4 beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 442.0
TLS2_k127_627218_5 cystathione gamma lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 420.0
TLS2_k127_627218_6 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K09972,K10041 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 408.0
TLS2_k127_627218_7 PFAM Integrase, catalytic core - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 411.0
TLS2_k127_627218_8 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 384.0
TLS2_k127_627218_9 ATPases associated with a variety of cellular activities K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 378.0
TLS2_k127_6420098_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 546.0
TLS2_k127_6420098_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009781 298.0
TLS2_k127_6420098_10 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000005483 56.0
TLS2_k127_6420098_2 ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001072 250.0
TLS2_k127_6420098_3 Putative glycosyl hydrolase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001633 257.0
TLS2_k127_6420098_4 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000001244 226.0
TLS2_k127_6420098_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000001017 210.0
TLS2_k127_6420098_6 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000373 206.0
TLS2_k127_6420098_7 PFAM Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000002394 177.0
TLS2_k127_6420098_8 RibD C-terminal domain - - - 0.000000000000000000000000000000000000009462 154.0
TLS2_k127_6420098_9 Rieske 2Fe-2S K05710 - - 0.000000000000000000000000102 116.0
TLS2_k127_6546797_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.995e-215 680.0
TLS2_k127_6546797_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009471 466.0
TLS2_k127_6546797_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 391.0
TLS2_k127_6546797_3 Bacterial sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 355.0
TLS2_k127_6546797_4 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 321.0
TLS2_k127_6546797_5 - - - - 0.000000003212 66.0
TLS2_k127_6546797_6 polysaccharide biosynthetic process K01992 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0044764,GO:0046812,GO:0051704 - 0.00000005533 65.0
TLS2_k127_6552396_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 490.0
TLS2_k127_6552396_1 ABC transporter K02028,K09972 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 334.0
TLS2_k127_6552396_2 Binding-protein-dependent transport system inner membrane component K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 331.0
TLS2_k127_6552396_3 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001142 258.0
TLS2_k127_6552396_4 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000008774 239.0
TLS2_k127_6552396_5 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000000000003237 194.0
TLS2_k127_6552396_6 protein conserved in bacteria - - - 0.0000000000000000000000000000000000001952 148.0
TLS2_k127_6552396_7 Inner membrane component domain - - - 0.000000000000000000000000000000000008897 140.0
TLS2_k127_6552396_8 - - - - 0.000000001364 62.0
TLS2_k127_6552396_9 Bacterial transcriptional activator domain - - - 0.00000000599 60.0
TLS2_k127_6613515_0 - - - - 1.166e-217 721.0
TLS2_k127_6613515_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 622.0
TLS2_k127_6613515_10 Pkd domain containing protein - - - 0.00000000000000000000000000001925 128.0
TLS2_k127_6613515_11 Transcriptional regulator - - - 0.00000000000000000000000002484 114.0
TLS2_k127_6613515_12 - - - - 0.0000000000000000001704 102.0
TLS2_k127_6613515_13 - - - - 0.00000000000001676 76.0
TLS2_k127_6613515_14 Transcriptional regulator - - - 0.0000000000002715 77.0
TLS2_k127_6613515_15 - - - - 0.00000000004105 73.0
TLS2_k127_6613515_16 tape measure protein - - - 0.0000000000813 76.0
TLS2_k127_6613515_2 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 544.0
TLS2_k127_6613515_3 Lecithin:cholesterol acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 385.0
TLS2_k127_6613515_4 Dihydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 371.0
TLS2_k127_6613515_5 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 341.0
TLS2_k127_6613515_6 protein import - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 334.0
TLS2_k127_6613515_7 CHAT domain - - - 0.000000000000000000000000000000000000000000000000008053 205.0
TLS2_k127_6613515_8 Cellulase N-terminal ig-like domain K01179 - 3.2.1.4 0.00000000000000000000000000000000009023 154.0
TLS2_k127_6613515_9 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.00000000000000000000000000000000247 132.0
TLS2_k127_661604_0 Clp amino terminal domain, pathogenicity island component K03696 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - 0.0 1145.0
TLS2_k127_661604_1 helicase K03724 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 6.562e-281 896.0
TLS2_k127_661604_10 cytochrome p450 K00493 - 1.14.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 325.0
TLS2_k127_661604_11 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002743 261.0
TLS2_k127_661604_12 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000008693 256.0
TLS2_k127_661604_13 Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process K07067 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000001277 257.0
TLS2_k127_661604_14 Pfam:Zinicin_2 - - - 0.00000000000000000000000000000000000000000000000000000000000000003494 239.0
TLS2_k127_661604_15 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000005863 214.0
TLS2_k127_661604_16 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000001073 205.0
TLS2_k127_661604_17 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.00000000000000000000000000000000000002422 153.0
TLS2_k127_661604_18 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.0000000000000000000000000000000000008664 145.0
TLS2_k127_661604_19 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.00000000000000000000000000000000003182 146.0
TLS2_k127_661604_2 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 5.913e-234 733.0
TLS2_k127_661604_20 CarD family transcriptional regulator K07736 GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - 0.000000000000000000000000000000003919 140.0
TLS2_k127_661604_21 Protein conserved in bacteria - - - 0.0000000000000000000000000000001067 137.0
TLS2_k127_661604_22 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K13940 GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 0.0000000000000000000000000000003538 128.0
TLS2_k127_661604_23 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075 GO:0008150,GO:0040007 2.4.2.8,6.3.4.19 0.000000000000000000000000000009293 134.0
TLS2_k127_661604_24 NADP oxidoreductase coenzyme F420-dependent - - - 0.00000000000000000000000000002281 128.0
TLS2_k127_661604_25 - - - - 0.00000000000000000000000001744 115.0
TLS2_k127_661604_26 D-alanyl-D-alanine carboxypeptidase - - - 0.00000000000000006788 89.0
TLS2_k127_661604_27 Putative adhesin - - - 0.0000000000000001245 92.0
TLS2_k127_661604_28 membrane K08972 - - 0.00000000000003314 79.0
TLS2_k127_661604_29 HicB family - - - 0.000000000001537 75.0
TLS2_k127_661604_3 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 1.992e-229 728.0
TLS2_k127_661604_4 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 499.0
TLS2_k127_661604_5 basic membrane K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 436.0
TLS2_k127_661604_6 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 438.0
TLS2_k127_661604_7 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009651 425.0
TLS2_k127_661604_8 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009686 410.0
TLS2_k127_661604_9 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 353.0
TLS2_k127_6671921_0 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 374.0
TLS2_k127_6671921_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000009717 238.0
TLS2_k127_6671921_10 colicin V production K03558 - - 0.0002961 52.0
TLS2_k127_6671921_11 - - - - 0.0003837 51.0
TLS2_k127_6671921_12 Cell envelope-related transcriptional attenuator domain - - - 0.0005241 49.0
TLS2_k127_6671921_2 Threonyl and Alanyl tRNA synthetase second additional domain K07050 - - 0.0000000000000000000000000000000000000000000000000000000000000174 228.0
TLS2_k127_6671921_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000004028 221.0
TLS2_k127_6671921_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000004743 172.0
TLS2_k127_6671921_5 - K00712 - 2.4.1.52 0.0000000000000000000000000000000000001129 148.0
TLS2_k127_6671921_6 AI-2E family transporter - - - 0.0000000000000000000000000000000001812 148.0
TLS2_k127_6671921_7 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000004381 100.0
TLS2_k127_6671921_8 SnoaL-like polyketide cyclase K15945 - - 0.000000000000000005796 86.0
TLS2_k127_6732698_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K12954,K12956,K17686,K21887 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0042221,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0050896,GO:0051704,GO:0071944 3.6.3.4,3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007248 435.0
TLS2_k127_6732698_1 metalloendopeptidase activity K01392,K01414 - 3.4.24.15,3.4.24.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 356.0
TLS2_k127_6732698_2 MerR, DNA binding - - - 0.0000000000000000000000000000000000000191 151.0
TLS2_k127_6759869_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 6.384e-286 903.0
TLS2_k127_6759869_1 Belongs to the peptidase S8 family - - - 6.601e-256 822.0
TLS2_k127_6759869_10 Binding-protein-dependent transport system inner membrane component K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 333.0
TLS2_k127_6759869_11 COG1175 ABC-type sugar transport systems permease components K10233 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 329.0
TLS2_k127_6759869_12 Bacterial extracellular solute-binding protein K10232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 318.0
TLS2_k127_6759869_13 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001226 261.0
TLS2_k127_6759869_14 ROK family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000004829 244.0
TLS2_k127_6759869_15 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000002794 239.0
TLS2_k127_6759869_16 Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000004312 241.0
TLS2_k127_6759869_17 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000852 237.0
TLS2_k127_6759869_18 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000001778 228.0
TLS2_k127_6759869_19 AMP-binding enzyme C-terminal domain K01911 - 6.2.1.26 0.000000000000000000000000000000000000000000000000000000000000001015 235.0
TLS2_k127_6759869_2 Uncharacterized protein family (UPF0051) K09014 - - 1.345e-222 697.0
TLS2_k127_6759869_20 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000001883 175.0
TLS2_k127_6759869_21 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000008682 176.0
TLS2_k127_6759869_22 PFAM O-methyltransferase, family 3 K00588 - 2.1.1.104 0.000000000000000000000000000000000000002211 154.0
TLS2_k127_6759869_23 Disulfide bond formation protein DsbB K03611 - - 0.000000000000000000000000000000000001295 149.0
TLS2_k127_6759869_24 Redoxin - - - 0.000000000000000000000000001317 123.0
TLS2_k127_6759869_25 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000001539 104.0
TLS2_k127_6759869_26 Peptidase family M23 K21472 - - 0.000000000000000000003214 102.0
TLS2_k127_6759869_27 translation release factor activity K02835,K15034 - - 0.00000000000000000005645 100.0
TLS2_k127_6759869_28 - - - - 0.0000000000000000003205 97.0
TLS2_k127_6759869_29 NifU-like domain - - - 0.0000000000000001182 89.0
TLS2_k127_6759869_3 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 616.0
TLS2_k127_6759869_30 META domain - - - 0.00000000005981 72.0
TLS2_k127_6759869_4 Alpha amylase catalytic K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 602.0
TLS2_k127_6759869_5 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 494.0
TLS2_k127_6759869_6 ATPases associated with a variety of cellular activities K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 446.0
TLS2_k127_6759869_7 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 GO:0008150,GO:0040007 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 427.0
TLS2_k127_6759869_8 Domain of unknown function (DUF4032) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 385.0
TLS2_k127_6759869_9 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 379.0
TLS2_k127_6796246_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 424.0
TLS2_k127_6796246_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 302.0
TLS2_k127_6796246_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000002917 181.0
TLS2_k127_6796246_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000001582 160.0
TLS2_k127_6796246_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360 3.6.4.12 0.0000000000000000000000000000000006894 139.0
TLS2_k127_6796246_5 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000009544 149.0
TLS2_k127_6796246_6 Sigma-70, region 4 K03088 - - 0.0000000000000000000000001363 113.0
TLS2_k127_6822647_0 FAD dependent oxidoreductase central domain - - - 0.0 1179.0
TLS2_k127_6822647_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 3.058e-285 901.0
TLS2_k127_6822647_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001012 247.0
TLS2_k127_6822647_11 ANTAR domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000004473 237.0
TLS2_k127_6822647_12 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000001271 223.0
TLS2_k127_6822647_13 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000002671 217.0
TLS2_k127_6822647_14 Belongs to the sigma-70 factor family K03090 GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000000000057 205.0
TLS2_k127_6822647_15 ANTAR - - - 0.00000000000000000000000000000000000000003545 161.0
TLS2_k127_6822647_16 MarR family - - - 0.00000000000000000000000000000000001586 142.0
TLS2_k127_6822647_17 Electron transfer DM13 - - - 0.0000000000000000000000000001216 124.0
TLS2_k127_6822647_18 Hydrogenase maturation protease K03605 - - 0.0000000000000000000000002161 111.0
TLS2_k127_6822647_19 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000119 117.0
TLS2_k127_6822647_2 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 591.0
TLS2_k127_6822647_20 Methyltransferase - - - 0.00000000000000000000001212 111.0
TLS2_k127_6822647_21 - - - - 0.0000000000000000000007301 103.0
TLS2_k127_6822647_22 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000222 70.0
TLS2_k127_6822647_3 COG0474 Cation transport ATPase K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 602.0
TLS2_k127_6822647_4 Aldo/keto reductase family K16950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 480.0
TLS2_k127_6822647_5 coenzyme F420 hydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 389.0
TLS2_k127_6822647_6 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 357.0
TLS2_k127_6822647_7 2 iron, 2 sulfur cluster binding K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 341.0
TLS2_k127_6822647_8 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 306.0
TLS2_k127_6822647_9 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003023 273.0
TLS2_k127_6836694_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 612.0
TLS2_k127_6836694_1 Dehydrogenase K00004,K00060,K08322 GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0030246,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701 1.1.1.103,1.1.1.303,1.1.1.380,1.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 530.0
TLS2_k127_6836694_10 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000005165 222.0
TLS2_k127_6836694_11 PFAM extracellular solute-binding protein, family 5 - - - 0.0000000000000000000000000000000000000000000000000000000001922 226.0
TLS2_k127_6836694_12 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000006413 204.0
TLS2_k127_6836694_13 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000006291 204.0
TLS2_k127_6836694_14 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000001651 194.0
TLS2_k127_6836694_15 PFAM Uncharacterised ACR, COG1259 K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000001921 187.0
TLS2_k127_6836694_16 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000002526 191.0
TLS2_k127_6836694_17 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000001399 178.0
TLS2_k127_6836694_18 Belongs to the thioredoxin family K00384,K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.9 0.000000000000000000000000000000000000000000000001473 177.0
TLS2_k127_6836694_19 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000005701 175.0
TLS2_k127_6836694_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 449.0
TLS2_k127_6836694_20 merR family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000021 178.0
TLS2_k127_6836694_21 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000003347 173.0
TLS2_k127_6836694_22 SMART ATP-binding region ATPase domain protein K03320 - - 0.00000000000000000000000000000000000000003813 165.0
TLS2_k127_6836694_23 YbaK prolyl-tRNA synthetase associated region - - - 0.0000000000000000000000000000000000000003736 154.0
TLS2_k127_6836694_24 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000005115 155.0
TLS2_k127_6836694_25 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000001283 145.0
TLS2_k127_6836694_26 Psort location Cytoplasmic, score K00760 - 2.4.2.8 0.000000000000000000000000000000007635 139.0
TLS2_k127_6836694_27 Protein of unknown function DUF126 K09128 - - 0.00000000000000000000000000000009755 132.0
TLS2_k127_6836694_28 Forkhead associated domain - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170 - 0.0000000000000000000000005951 112.0
TLS2_k127_6836694_29 helix_turn_helix, Lux Regulon - - - 0.000000000000000000005703 106.0
TLS2_k127_6836694_3 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005766 421.0
TLS2_k127_6836694_30 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000001111 92.0
TLS2_k127_6836694_31 Tetratricopeptide repeat - - - 0.000000000000411 79.0
TLS2_k127_6836694_32 - - - - 0.0000000003156 66.0
TLS2_k127_6836694_33 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000001794 64.0
TLS2_k127_6836694_34 - - - - 0.000001069 53.0
TLS2_k127_6836694_35 hydrolase K01048 - 3.1.1.5 0.000001333 49.0
TLS2_k127_6836694_37 - - - - 0.00001591 47.0
TLS2_k127_6836694_4 UDP-glucose 4-epimerase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 409.0
TLS2_k127_6836694_5 Adenosine/AMP deaminase K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 332.0
TLS2_k127_6836694_6 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 310.0
TLS2_k127_6836694_7 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002666 288.0
TLS2_k127_6836694_8 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002937 281.0
TLS2_k127_6836694_9 hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000001333 230.0
TLS2_k127_6866509_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007538 572.0
TLS2_k127_6866509_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009324 549.0
TLS2_k127_6866509_2 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 376.0
TLS2_k127_6866509_3 Predicted membrane protein (DUF2079) K07778 - 2.7.13.3 0.00000000000000000000000000000000000000000007158 177.0
TLS2_k127_6866509_4 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000001799 161.0
TLS2_k127_6866509_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000002689 161.0
TLS2_k127_6866509_7 alginic acid biosynthetic process - - - 0.000000000000000000000000000394 124.0
TLS2_k127_6866509_8 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000001214 106.0
TLS2_k127_6899889_0 AMP-binding enzyme K01897 - 6.2.1.3 5.581e-242 771.0
TLS2_k127_6899889_1 Nitrous oxide reductase K00376 - 1.7.2.4 8.678e-238 753.0
TLS2_k127_6899889_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 361.0
TLS2_k127_6899889_11 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 356.0
TLS2_k127_6899889_12 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 333.0
TLS2_k127_6899889_13 Amino acid amide ABC transporter ATP-binding protein 1, HAAT family K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 322.0
TLS2_k127_6899889_14 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 321.0
TLS2_k127_6899889_15 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 322.0
TLS2_k127_6899889_16 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 320.0
TLS2_k127_6899889_17 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 305.0
TLS2_k127_6899889_18 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 291.0
TLS2_k127_6899889_19 PFAM Integrase, catalytic core - - - 0.0000000000000000000000000000000000000000000000000000000000000439 228.0
TLS2_k127_6899889_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007749 581.0
TLS2_k127_6899889_20 PFAM isochorismatase hydrolase K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000001666 218.0
TLS2_k127_6899889_21 transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000003499 227.0
TLS2_k127_6899889_22 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000001633 190.0
TLS2_k127_6899889_23 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000004476 173.0
TLS2_k127_6899889_24 Pfam Zn-finger in ubiquitin-hydrolases and other protein K03455 - - 0.0000000000000000000000000000000000000000004461 158.0
TLS2_k127_6899889_25 alginic acid biosynthetic process K07218 - - 0.0000000000000000000000000000000000000000008682 179.0
TLS2_k127_6899889_26 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000003418 141.0
TLS2_k127_6899889_27 COGs COG0628 permease - - - 0.0000000000000000000000000001986 128.0
TLS2_k127_6899889_28 Histidine kinase K07654 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.00000000000000000000000004615 120.0
TLS2_k127_6899889_29 Rrf2 family - - - 0.00000000000000000000004537 104.0
TLS2_k127_6899889_3 NeuB family K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007829 484.0
TLS2_k127_6899889_30 lipoprotein involved in nitrous oxide reduction K19342 - - 0.00000000000000000009938 105.0
TLS2_k127_6899889_31 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000001009 89.0
TLS2_k127_6899889_32 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000001149 87.0
TLS2_k127_6899889_33 Belongs to the UPF0235 family K09131 - - 0.000000000000002322 80.0
TLS2_k127_6899889_35 ABC-2 family transporter protein K19341 - - 0.0003327 53.0
TLS2_k127_6899889_4 Psort location CytoplasmicMembrane, score 10.00 K03458 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009526 469.0
TLS2_k127_6899889_5 PFAM Na Picotransporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005962 458.0
TLS2_k127_6899889_6 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 432.0
TLS2_k127_6899889_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009504 419.0
TLS2_k127_6899889_8 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008966 380.0
TLS2_k127_6899889_9 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 360.0
TLS2_k127_6999387_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 2.368e-217 683.0
TLS2_k127_6999387_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.3.14 1.259e-209 662.0
TLS2_k127_6999387_10 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 378.0
TLS2_k127_6999387_11 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 359.0
TLS2_k127_6999387_12 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 362.0
TLS2_k127_6999387_13 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 350.0
TLS2_k127_6999387_14 purine nucleotide biosynthetic process K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 311.0
TLS2_k127_6999387_15 Na+/Pi-cotransporter K03324,K14683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 308.0
TLS2_k127_6999387_16 PFAM ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008148 300.0
TLS2_k127_6999387_17 Threonine synthase N terminus K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 293.0
TLS2_k127_6999387_18 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003143 293.0
TLS2_k127_6999387_19 helix_turn_helix, Lux Regulon K07693 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008385 263.0
TLS2_k127_6999387_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 542.0
TLS2_k127_6999387_20 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000765 258.0
TLS2_k127_6999387_21 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001214 259.0
TLS2_k127_6999387_22 cytochrome P450 K21034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001863 255.0
TLS2_k127_6999387_23 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000295 248.0
TLS2_k127_6999387_24 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003287 245.0
TLS2_k127_6999387_25 Psort location CytoplasmicMembrane, score 10.00 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001942 247.0
TLS2_k127_6999387_26 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000002269 243.0
TLS2_k127_6999387_27 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000001738 233.0
TLS2_k127_6999387_28 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000001165 224.0
TLS2_k127_6999387_29 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000001764 221.0
TLS2_k127_6999387_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 516.0
TLS2_k127_6999387_30 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000002672 218.0
TLS2_k127_6999387_31 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000001362 224.0
TLS2_k127_6999387_32 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000002455 228.0
TLS2_k127_6999387_33 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07778 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000001204 218.0
TLS2_k127_6999387_34 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000008944 201.0
TLS2_k127_6999387_35 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000007808 200.0
TLS2_k127_6999387_36 glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000002409 192.0
TLS2_k127_6999387_37 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000007044 182.0
TLS2_k127_6999387_38 rRNA (adenine-N6,N6-)-dimethyltransferase activity K15266 - - 0.0000000000000000000000000000000000000000000002085 185.0
TLS2_k127_6999387_39 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000005303 173.0
TLS2_k127_6999387_4 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 514.0
TLS2_k127_6999387_40 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000003362 170.0
TLS2_k127_6999387_41 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000009992 158.0
TLS2_k127_6999387_42 Zn peptidase - - - 0.0000000000000000000000000000000000000002517 166.0
TLS2_k127_6999387_43 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000003371 156.0
TLS2_k127_6999387_44 Domain of unknown function (DUF4380) - - - 0.0000000000000000000000000000000000000004819 160.0
TLS2_k127_6999387_45 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 0.000000000000000000000000000000002686 143.0
TLS2_k127_6999387_46 Yqey-like protein K09117 - - 0.0000000000000000000000000000000121 133.0
TLS2_k127_6999387_47 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000008653 141.0
TLS2_k127_6999387_48 MgtC SapB transporter K07507 - - 0.00000000000000000000000000007706 121.0
TLS2_k127_6999387_49 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109,K02113 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000001331 121.0
TLS2_k127_6999387_5 (ABC) transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005153 448.0
TLS2_k127_6999387_50 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000000000000002075 123.0
TLS2_k127_6999387_51 PhoU domain - - - 0.0000000000000000000000000007214 121.0
TLS2_k127_6999387_52 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000147 121.0
TLS2_k127_6999387_53 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA K18955 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000003708 117.0
TLS2_k127_6999387_54 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000004803 112.0
TLS2_k127_6999387_55 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000001255 112.0
TLS2_k127_6999387_56 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000001337 122.0
TLS2_k127_6999387_57 Binds the 23S rRNA K02909 - - 0.00000000000000000000000003149 112.0
TLS2_k127_6999387_58 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000006258 92.0
TLS2_k127_6999387_59 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000003762 88.0
TLS2_k127_6999387_6 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 427.0
TLS2_k127_6999387_60 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000005441 93.0
TLS2_k127_6999387_62 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000001207 86.0
TLS2_k127_6999387_63 Transcriptional regulator, AbrB family K06284 - - 0.000000000000001183 81.0
TLS2_k127_6999387_64 PFAM class II aldolase adducin family protein K03077 - 5.1.3.4 0.00000000001131 66.0
TLS2_k127_6999387_65 4Fe-4S ferredoxin iron-sulfur binding domain protein K05337 - - 0.0000000005444 63.0
TLS2_k127_6999387_66 - - - - 0.000000001385 67.0
TLS2_k127_6999387_67 - - - - 0.00000007497 58.0
TLS2_k127_6999387_68 PFAM Peptidoglycan-binding lysin domain - - - 0.00000009906 58.0
TLS2_k127_6999387_69 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.0000008588 53.0
TLS2_k127_6999387_7 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 416.0
TLS2_k127_6999387_70 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.000001559 53.0
TLS2_k127_6999387_71 Uncharacterized ACR, COG1430 K09005 - - 0.0001851 48.0
TLS2_k127_6999387_72 Protein of unknown function (DUF3107) - - - 0.0004248 49.0
TLS2_k127_6999387_8 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 409.0
TLS2_k127_6999387_9 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 383.0
TLS2_k127_7039957_0 Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 471.0
TLS2_k127_7039957_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000076 296.0
TLS2_k127_7039957_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000002037 250.0
TLS2_k127_7039957_3 PFAM Rod shape-determining protein MreC K03570 - - 0.0000001987 63.0
TLS2_k127_7111670_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 537.0
TLS2_k127_7111670_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 323.0
TLS2_k127_7111670_2 Peptidase family M50 K11749 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000002916 214.0
TLS2_k127_7111670_3 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000008641 139.0
TLS2_k127_7111670_4 Sigma-70, region 4 K03088 - - 0.0003676 45.0
TLS2_k127_713150_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1232.0
TLS2_k127_713150_1 Metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 571.0
TLS2_k127_713150_10 PFAM peptidase C45 acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase K19200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 291.0
TLS2_k127_713150_11 molybdopterin K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001545 291.0
TLS2_k127_713150_12 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001679 283.0
TLS2_k127_713150_13 PFAM FAD dependent oxidoreductase K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006872 281.0
TLS2_k127_713150_14 Belongs to the DapB family K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000002641 228.0
TLS2_k127_713150_15 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000009398 230.0
TLS2_k127_713150_16 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.0000000000000000000000000000000000000000000000000000001712 211.0
TLS2_k127_713150_17 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K08299 - 4.2.1.149 0.00000000000000000000000000000000000000000000000000001309 198.0
TLS2_k127_713150_18 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000455 192.0
TLS2_k127_713150_19 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000006062 181.0
TLS2_k127_713150_2 Belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 517.0
TLS2_k127_713150_20 PFAM Translin K07477 - - 0.0000000000000000000000000000000000000000000007055 178.0
TLS2_k127_713150_21 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000007853 171.0
TLS2_k127_713150_22 HD domain - - - 0.00000000000000000000000000000000000000007915 169.0
TLS2_k127_713150_23 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000008729 154.0
TLS2_k127_713150_24 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000003266 145.0
TLS2_k127_713150_25 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000000009126 133.0
TLS2_k127_713150_26 Transcriptional regulator - - - 0.00000000000000000000000000002529 130.0
TLS2_k127_713150_27 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.000000000000000000000000007624 118.0
TLS2_k127_713150_28 Domain of unknown function (DUF4349) - - - 0.0000000000000000000000009228 121.0
TLS2_k127_713150_29 - - - - 0.000000000000000000002068 102.0
TLS2_k127_713150_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 422.0
TLS2_k127_713150_30 Regulatory protein, FmdB family - - - 0.000000000000000001099 94.0
TLS2_k127_713150_31 Acetyltransferase (GNAT) family - - - 0.0000000000000001841 86.0
TLS2_k127_713150_32 Family of unknown function (DUF5317) - - - 0.0000000000004376 77.0
TLS2_k127_713150_33 Protein of unknown function (DUF2752) - - - 0.00000001183 61.0
TLS2_k127_713150_34 COG0389 Nucleotidyltransferase DNA polymerase involved in DNA repair - - - 0.0000002292 57.0
TLS2_k127_713150_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 421.0
TLS2_k127_713150_5 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 367.0
TLS2_k127_713150_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 363.0
TLS2_k127_713150_7 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 346.0
TLS2_k127_713150_8 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 316.0
TLS2_k127_713150_9 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 319.0
TLS2_k127_7136999_0 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 7.263e-202 644.0
TLS2_k127_7136999_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 303.0
TLS2_k127_7136999_2 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000000000000000000000008168 180.0
TLS2_k127_7136999_3 Iron-sulphur cluster biosynthesis K13628 - - 0.0000000000000000000000000000000000009578 141.0
TLS2_k127_7136999_4 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000001231 123.0
TLS2_k127_7249793_0 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 602.0
TLS2_k127_7249793_1 PFAM extracellular solute-binding protein family 1 K10232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 485.0
TLS2_k127_7249793_10 PFAM Binding-protein-dependent transport system inner membrane component K02025,K10233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 322.0
TLS2_k127_7249793_11 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 304.0
TLS2_k127_7249793_12 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003539 284.0
TLS2_k127_7249793_13 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009811 280.0
TLS2_k127_7249793_14 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003629 274.0
TLS2_k127_7249793_15 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000082 269.0
TLS2_k127_7249793_16 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000005809 263.0
TLS2_k127_7249793_17 Alanine dehydrogenase/PNT, C-terminal domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001026 265.0
TLS2_k127_7249793_18 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000002503 239.0
TLS2_k127_7249793_19 PFAM Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000001981 217.0
TLS2_k127_7249793_2 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 461.0
TLS2_k127_7249793_20 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000003299 213.0
TLS2_k127_7249793_21 Protein of unknown function (DUF2867) - - - 0.000000000000000000000000000000000000000000000005538 190.0
TLS2_k127_7249793_22 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000003778 164.0
TLS2_k127_7249793_23 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000001325 162.0
TLS2_k127_7249793_24 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000002808 153.0
TLS2_k127_7249793_25 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.0000000000000000000000000000000000000697 151.0
TLS2_k127_7249793_26 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000004451 120.0
TLS2_k127_7249793_27 Ribosomal L27 protein K02899 - - 0.00000000000000000000000000174 113.0
TLS2_k127_7249793_28 - - - - 0.000000000000000000000000002118 122.0
TLS2_k127_7249793_29 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000372 120.0
TLS2_k127_7249793_3 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003695 447.0
TLS2_k127_7249793_30 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000005458 119.0
TLS2_k127_7249793_31 GYD domain - - - 0.000000000000000000000001173 107.0
TLS2_k127_7249793_32 cheY-homologous receiver domain - - - 0.000000000000000000000005553 106.0
TLS2_k127_7249793_34 - - - - 0.000000000003948 78.0
TLS2_k127_7249793_35 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.000000004019 66.0
TLS2_k127_7249793_36 - - - - 0.000000005694 61.0
TLS2_k127_7249793_37 Peptidase family M23 - - - 0.00000004259 63.0
TLS2_k127_7249793_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 439.0
TLS2_k127_7249793_5 PFAM binding-protein-dependent transport systems inner membrane component K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 385.0
TLS2_k127_7249793_6 ATPase associated with various cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009365 362.0
TLS2_k127_7249793_7 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006691 364.0
TLS2_k127_7249793_8 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 336.0
TLS2_k127_7249793_9 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 339.0
TLS2_k127_7286224_0 RimK-like ATP-grasp domain K03802 - 6.3.2.29,6.3.2.30 0.0 1131.0
TLS2_k127_7286224_1 Tetratrico peptide repeat K03802 - 6.3.2.29,6.3.2.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 420.0
TLS2_k127_7286224_2 Peptidase family S51 K13282 - 3.4.15.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000023 288.0
TLS2_k127_7286224_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000001809 219.0
TLS2_k127_7286224_4 - - - - 0.000000000000000000000000000000000000000000000000000000000004639 222.0
TLS2_k127_7299882_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 0.0 1028.0
TLS2_k127_7299882_1 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 3.097e-255 807.0
TLS2_k127_7299882_10 Pyridoxal-phosphate dependent enzyme K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 392.0
TLS2_k127_7299882_11 Phosphoserine phosphatase K01079 GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006607 378.0
TLS2_k127_7299882_12 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 362.0
TLS2_k127_7299882_13 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 353.0
TLS2_k127_7299882_14 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 339.0
TLS2_k127_7299882_15 Oxidoreductase NAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 308.0
TLS2_k127_7299882_16 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000103 291.0
TLS2_k127_7299882_17 PFAM type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 307.0
TLS2_k127_7299882_18 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001948 281.0
TLS2_k127_7299882_19 Patched family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007746 294.0
TLS2_k127_7299882_2 helicase activity - - - 1.02e-224 728.0
TLS2_k127_7299882_20 haloacid dehalogenase-like hydrolase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000001438 252.0
TLS2_k127_7299882_21 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000292 248.0
TLS2_k127_7299882_22 May catalyze the transamination reaction in phenylalanine biosynthesis K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000009639 273.0
TLS2_k127_7299882_23 ROK family K00845,K00886 - 2.7.1.2,2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000005213 242.0
TLS2_k127_7299882_24 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000000000000000000008748 232.0
TLS2_k127_7299882_25 heme a metabolic process K02257,K02259 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000001485 237.0
TLS2_k127_7299882_26 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000001556 213.0
TLS2_k127_7299882_27 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000001093 207.0
TLS2_k127_7299882_28 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000001319 200.0
TLS2_k127_7299882_29 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000002909 196.0
TLS2_k127_7299882_3 Peptidase family M1 domain K08776 - - 7.183e-207 671.0
TLS2_k127_7299882_30 MerR, DNA binding K13639 - - 0.0000000000000000000000000000000000000000000000000000308 191.0
TLS2_k127_7299882_31 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000007585 192.0
TLS2_k127_7299882_32 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000005729 171.0
TLS2_k127_7299882_33 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000002875 159.0
TLS2_k127_7299882_34 - - - - 0.00000000000000000000000000000000003184 140.0
TLS2_k127_7299882_35 PFAM MarR family - - - 0.00000000000000000000000000000000003497 139.0
TLS2_k127_7299882_36 peptidase - - - 0.00000000000000000000000000000000009518 142.0
TLS2_k127_7299882_37 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000663 133.0
TLS2_k127_7299882_38 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000216 131.0
TLS2_k127_7299882_4 DNA polymerase beta thumb K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 621.0
TLS2_k127_7299882_40 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000002448 132.0
TLS2_k127_7299882_41 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000002266 120.0
TLS2_k127_7299882_42 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000002333 112.0
TLS2_k127_7299882_43 F420H(2)-dependent quinone reductase - - - 0.00000000000000000001676 101.0
TLS2_k127_7299882_44 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000009264 93.0
TLS2_k127_7299882_45 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000536 83.0
TLS2_k127_7299882_46 Protein of unknown function (DUF1761) - - - 0.00000157 56.0
TLS2_k127_7299882_47 TadE-like protein - - - 0.00007607 53.0
TLS2_k127_7299882_49 Flp Fap pilin component K02651 - - 0.000928 50.0
TLS2_k127_7299882_5 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008641 604.0
TLS2_k127_7299882_6 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 565.0
TLS2_k127_7299882_7 ABC transporter transmembrane region K02021,K06147,K16786,K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 501.0
TLS2_k127_7299882_8 ABC transporter, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 454.0
TLS2_k127_7299882_9 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 406.0
TLS2_k127_7354765_0 UvrD-like helicase C-terminal domain K03657 GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 3.618e-240 765.0
TLS2_k127_7354765_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.972e-223 704.0
TLS2_k127_7354765_10 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009954 458.0
TLS2_k127_7354765_11 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 447.0
TLS2_k127_7354765_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 450.0
TLS2_k127_7354765_13 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 441.0
TLS2_k127_7354765_14 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 426.0
TLS2_k127_7354765_15 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 436.0
TLS2_k127_7354765_16 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 417.0
TLS2_k127_7354765_17 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 423.0
TLS2_k127_7354765_18 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 396.0
TLS2_k127_7354765_19 tryptophan 2,3-dioxygenase activity K00453,K03392 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11,4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 394.0
TLS2_k127_7354765_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 586.0
TLS2_k127_7354765_20 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008277 392.0
TLS2_k127_7354765_21 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 363.0
TLS2_k127_7354765_22 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 349.0
TLS2_k127_7354765_23 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 332.0
TLS2_k127_7354765_24 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009156 323.0
TLS2_k127_7354765_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 311.0
TLS2_k127_7354765_26 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 315.0
TLS2_k127_7354765_27 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 294.0
TLS2_k127_7354765_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001647 257.0
TLS2_k127_7354765_29 Putative methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009457 254.0
TLS2_k127_7354765_3 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 580.0
TLS2_k127_7354765_30 chemotaxis protein K03407,K13490 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000001442 245.0
TLS2_k127_7354765_31 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000005801 220.0
TLS2_k127_7354765_32 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000002338 201.0
TLS2_k127_7354765_33 KR domain - - - 0.000000000000000000000000000000000000000000000000000001301 202.0
TLS2_k127_7354765_34 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000001043 194.0
TLS2_k127_7354765_35 PFAM Phospholipid glycerol acyltransferase - - - 0.0000000000000000000000000000000000000000000000000001351 191.0
TLS2_k127_7354765_36 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000001469 208.0
TLS2_k127_7354765_37 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000004823 187.0
TLS2_k127_7354765_38 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000001351 186.0
TLS2_k127_7354765_39 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000000000000000000000003466 176.0
TLS2_k127_7354765_4 PFAM isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 572.0
TLS2_k127_7354765_40 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000002116 175.0
TLS2_k127_7354765_41 - - - - 0.0000000000000000000000000000000000000000001017 164.0
TLS2_k127_7354765_42 PhoQ Sensor - - - 0.0000000000000000000000000000000000002286 153.0
TLS2_k127_7354765_43 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 - 1.6.5.3 0.000000000000000000000000000000000656 138.0
TLS2_k127_7354765_44 PhoQ Sensor - - - 0.000000000000000000000000000000126 143.0
TLS2_k127_7354765_45 cell envelope-related transcriptional attenuator - - - 0.0000000000000000000000000000009952 134.0
TLS2_k127_7354765_46 Domain protein associated with RNAses G and E K07586 - - 0.00000000000000000000000000000626 126.0
TLS2_k127_7354765_47 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000001127 129.0
TLS2_k127_7354765_48 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.000000000000000000000000004507 123.0
TLS2_k127_7354765_49 Endoribonuclease L-PSP - - - 0.000000000000000000000000006233 117.0
TLS2_k127_7354765_5 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 509.0
TLS2_k127_7354765_50 MDMPI C-terminal domain - - - 0.00000000000000000000000001004 118.0
TLS2_k127_7354765_51 NUDIX domain - - - 0.0000000000000000000000001654 112.0
TLS2_k127_7354765_52 electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000534 113.0
TLS2_k127_7354765_53 CoA binding domain K06929 - - 0.00000000000000000000002149 105.0
TLS2_k127_7354765_54 - - - - 0.00000000000000000000003414 115.0
TLS2_k127_7354765_55 - - - - 0.0000000000000000000005981 105.0
TLS2_k127_7354765_56 Thioesterase-like superfamily K07107 - - 0.0000000000000000000009015 100.0
TLS2_k127_7354765_57 chromosome segregation K03497 - - 0.000000000000000000002082 104.0
TLS2_k127_7354765_58 helix_turn_helix, Lux Regulon - - - 0.000000000000000000002148 107.0
TLS2_k127_7354765_59 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000001586 106.0
TLS2_k127_7354765_6 Histidine ammonia-lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 503.0
TLS2_k127_7354765_60 Aminoglycoside-2''-adenylyltransferase - - - 0.00000000000000009286 93.0
TLS2_k127_7354765_61 Rhodanese-related sulfurtransferase - - - 0.000000000000004681 82.0
TLS2_k127_7354765_63 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000000000000233 79.0
TLS2_k127_7354765_64 - - - - 0.000000000005078 74.0
TLS2_k127_7354765_65 Polymer-forming cytoskeletal - - - 0.0000000004208 72.0
TLS2_k127_7354765_66 - - - - 0.000000001665 59.0
TLS2_k127_7354765_67 carboxylic ester hydrolase activity - - - 0.000000006824 66.0
TLS2_k127_7354765_68 CAAX protease self-immunity K07052 - - 0.00000001234 66.0
TLS2_k127_7354765_69 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.00002307 55.0
TLS2_k127_7354765_7 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 482.0
TLS2_k127_7354765_70 - - - - 0.00003515 52.0
TLS2_k127_7354765_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 467.0
TLS2_k127_7354765_9 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 472.0
TLS2_k127_7368819_0 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 9.802e-259 809.0
TLS2_k127_7368819_1 Rieske [2Fe-2S] domain K15060 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 590.0
TLS2_k127_7368819_10 helix_turn_helix isocitrate lyase regulation K19333 - - 0.00000000000000000000000000000000000000000000000000000000000000000001514 241.0
TLS2_k127_7368819_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001411 233.0
TLS2_k127_7368819_12 Fumarylacetoacetate (FAA) hydrolase family K01617 - 4.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000007171 233.0
TLS2_k127_7368819_13 hydratase K02509,K18364 - 4.2.1.132,4.2.1.80 0.000000000000000000000000000000000000000000000000000000158 203.0
TLS2_k127_7368819_14 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.00000000000000000000000000000000000001334 156.0
TLS2_k127_7368819_15 - - - - 0.00000000000000000000001303 102.0
TLS2_k127_7368819_16 phosphatase activity K07025,K20862,K20866 - 3.1.3.10,3.1.3.102,3.1.3.104 0.00000000000000000001688 103.0
TLS2_k127_7368819_17 of nitrite reductase and ring-hydroxylating dioxygenase K00363,K05710 - 1.7.1.15 0.00000000000000002817 86.0
TLS2_k127_7368819_18 - - - - 0.0000000000000855 74.0
TLS2_k127_7368819_19 Belongs to the 4-oxalocrotonate tautomerase family K01821 - 5.3.2.6 0.00000000005845 66.0
TLS2_k127_7368819_2 Belongs to the aldehyde dehydrogenase family K10217 - 1.2.1.32,1.2.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 519.0
TLS2_k127_7368819_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 457.0
TLS2_k127_7368819_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006249 459.0
TLS2_k127_7368819_5 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds K01666 - 4.1.3.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 419.0
TLS2_k127_7368819_6 Histidine phosphatase superfamily (branch 1) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 378.0
TLS2_k127_7368819_7 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 373.0
TLS2_k127_7368819_8 Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds K04073 - 1.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 361.0
TLS2_k127_7368819_9 Fumarylacetoacetate (FAA) hydrolase family K02554 - 4.2.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009453 276.0
TLS2_k127_7396231_0 AhpC/TSA family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 412.0
TLS2_k127_7396231_1 PFAM oxidoreductase, molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 309.0
TLS2_k127_7396231_2 Epoxide hydrolase N terminus K01253,K21159 - 3.3.2.9 0.000000000000000000000000000000000000000000000000000003602 191.0
TLS2_k127_7453655_0 DNA polymerase alpha chain like domain K02337 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 0.0 1191.0
TLS2_k127_7453655_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 2.654e-266 854.0
TLS2_k127_7453655_10 COGs COG0534 Na -driven multidrug efflux pump K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001027 283.0
TLS2_k127_7453655_11 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000001332 263.0
TLS2_k127_7453655_12 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000001579 262.0
TLS2_k127_7453655_13 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000001047 239.0
TLS2_k127_7453655_14 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000001416 216.0
TLS2_k127_7453655_15 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000653 221.0
TLS2_k127_7453655_16 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000002331 216.0
TLS2_k127_7453655_17 PFAM HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000008308 193.0
TLS2_k127_7453655_18 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000002502 195.0
TLS2_k127_7453655_19 Pfam Anion-transporting ATPase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000001705 184.0
TLS2_k127_7453655_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 563.0
TLS2_k127_7453655_20 Rhomboid family K19225 - 3.4.21.105 0.000000000000000000000000000000000000000000001995 175.0
TLS2_k127_7453655_21 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000001814 185.0
TLS2_k127_7453655_22 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000001055 162.0
TLS2_k127_7453655_23 anion-transporting ATPase - - - 0.00000000000000000000000000000000000007021 158.0
TLS2_k127_7453655_24 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.00000000000000000000000001301 119.0
TLS2_k127_7453655_25 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000002512 112.0
TLS2_k127_7453655_26 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.0000000000000000000001767 106.0
TLS2_k127_7453655_27 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA K09772 - - 0.0000000000000004799 85.0
TLS2_k127_7453655_28 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000385 76.0
TLS2_k127_7453655_29 - - - - 0.000000000003674 70.0
TLS2_k127_7453655_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008778 452.0
TLS2_k127_7453655_30 integral membrane protein K02221 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000003175 61.0
TLS2_k127_7453655_31 Major facilitator superfamily - - - 0.000000005298 68.0
TLS2_k127_7453655_32 Cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.0000003246 61.0
TLS2_k127_7453655_33 DivIVA protein K04074 - - 0.000001583 59.0
TLS2_k127_7453655_34 - - - - 0.0005464 46.0
TLS2_k127_7453655_35 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0009685 48.0
TLS2_k127_7453655_4 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 412.0
TLS2_k127_7453655_5 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 349.0
TLS2_k127_7453655_6 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0008150,GO:0040007 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 334.0
TLS2_k127_7453655_7 Penicillin-binding protein dimerisation domain K03587,K08384 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 319.0
TLS2_k127_7453655_8 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005312 278.0
TLS2_k127_7453655_9 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001007 278.0
TLS2_k127_7455845_0 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 434.0
TLS2_k127_7455845_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 413.0
TLS2_k127_7455845_10 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000001336 58.0
TLS2_k127_7455845_2 Cell cycle protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009196 308.0
TLS2_k127_7455845_3 Penicillin binding protein transpeptidase domain K05364 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000996 316.0
TLS2_k127_7455845_4 MFS_1 like family - - - 0.00000000000000000000000000000000000000000000000000000000000002341 232.0
TLS2_k127_7455845_5 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000005052 193.0
TLS2_k127_7455845_6 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.000000000000000000000000000000000000000000002482 168.0
TLS2_k127_7455845_7 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000009498 126.0
TLS2_k127_7455845_8 Forkhead associated domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.000000000000000001257 90.0
TLS2_k127_7455845_9 Protein of unknown function (DUF2662) - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.000000000000000003107 93.0
TLS2_k127_785757_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 317.0
TLS2_k127_785757_1 VanW like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000124 245.0
TLS2_k127_872366_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1493.0
TLS2_k127_872366_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1140.0
TLS2_k127_872366_10 Elongator protein 3 MiaB NifB K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 504.0
TLS2_k127_872366_11 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 495.0
TLS2_k127_872366_12 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008142 479.0
TLS2_k127_872366_13 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 404.0
TLS2_k127_872366_14 PFAM delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 399.0
TLS2_k127_872366_15 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 398.0
TLS2_k127_872366_16 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 413.0
TLS2_k127_872366_17 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009801 395.0
TLS2_k127_872366_18 Belongs to the peptidase M16 family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 387.0
TLS2_k127_872366_19 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 373.0
TLS2_k127_872366_2 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 3.581e-318 1007.0
TLS2_k127_872366_20 epoxide hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 370.0
TLS2_k127_872366_21 associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 364.0
TLS2_k127_872366_22 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 358.0
TLS2_k127_872366_23 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 338.0
TLS2_k127_872366_24 Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 322.0
TLS2_k127_872366_25 Dehydrogenase E1 component K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 325.0
TLS2_k127_872366_26 Phospholipid-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 303.0
TLS2_k127_872366_27 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009497 289.0
TLS2_k127_872366_28 cytokinin biosynthetic process K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009103 292.0
TLS2_k127_872366_29 Cytochrome c-type biogenesis protein CcmF K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 301.0
TLS2_k127_872366_3 NADH flavin oxidoreductase NADH oxidase K00354,K09461 GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700 1.14.13.40,1.6.99.1 1.129e-287 902.0
TLS2_k127_872366_30 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001407 271.0
TLS2_k127_872366_31 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000009215 276.0
TLS2_k127_872366_32 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000005176 274.0
TLS2_k127_872366_33 membrane K08974 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004801 259.0
TLS2_k127_872366_34 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002992 258.0
TLS2_k127_872366_35 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001511 264.0
TLS2_k127_872366_36 Major facilitator Superfamily K08153 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002993 256.0
TLS2_k127_872366_37 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000002677 241.0
TLS2_k127_872366_38 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000006772 254.0
TLS2_k127_872366_39 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000002119 237.0
TLS2_k127_872366_4 von Willebrand factor, type A K07114 - - 1.348e-261 859.0
TLS2_k127_872366_40 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000005908 239.0
TLS2_k127_872366_41 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000001822 218.0
TLS2_k127_872366_42 Membrane complex biogenesis protein, BtpA family K06971 - - 0.0000000000000000000000000000000000000000000000000000000002228 220.0
TLS2_k127_872366_43 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000006399 198.0
TLS2_k127_872366_44 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000005391 203.0
TLS2_k127_872366_45 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000001153 192.0
TLS2_k127_872366_46 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000001299 199.0
TLS2_k127_872366_47 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000001561 189.0
TLS2_k127_872366_48 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000962 175.0
TLS2_k127_872366_49 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000000000001006 178.0
TLS2_k127_872366_5 Tetratricopeptide repeat - - - 1.344e-212 698.0
TLS2_k127_872366_50 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000001256 169.0
TLS2_k127_872366_51 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000001082 153.0
TLS2_k127_872366_52 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000001239 159.0
TLS2_k127_872366_53 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000000000000000001835 141.0
TLS2_k127_872366_54 translation initiation factor activity - - - 0.0000000000000000000000000000000006113 149.0
TLS2_k127_872366_55 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000007734 137.0
TLS2_k127_872366_56 alpha/beta hydrolase fold - - - 0.00000000000000000000000000008675 130.0
TLS2_k127_872366_57 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000004918 120.0
TLS2_k127_872366_58 PFAM Flavin reductase like domain - - - 0.000000000000000000000000007067 115.0
TLS2_k127_872366_59 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000001533 113.0
TLS2_k127_872366_6 ABC transporter K06147 - - 2.069e-208 665.0
TLS2_k127_872366_60 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000005896 105.0
TLS2_k127_872366_61 transglycosylase associated protein - - - 0.000000000000000002284 88.0
TLS2_k127_872366_62 pyridoxamine 5'-phosphate K07005 - - 0.00000000000003989 79.0
TLS2_k127_872366_63 - - - - 0.0000000000003239 78.0
TLS2_k127_872366_64 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.0000000001227 70.0
TLS2_k127_872366_65 PFAM Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.0000001709 61.0
TLS2_k127_872366_66 CbbQ/NirQ/NorQ C-terminal K04748 - - 0.00001085 57.0
TLS2_k127_872366_67 domain, Protein K01218 - 3.2.1.78 0.00002097 54.0
TLS2_k127_872366_68 Universal stress protein - - - 0.00008969 51.0
TLS2_k127_872366_69 Dodecin K09165 - - 0.0008316 44.0
TLS2_k127_872366_7 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 580.0
TLS2_k127_872366_8 ABC transporter transmembrane region K06147,K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 566.0
TLS2_k127_872366_9 ABC transporter transmembrane region K06147,K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 558.0