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Overview

ID MAG04029
Name TLS2_bin.71
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Anaerolineae
Order Caldilineales
Family Caldilineaceae
Genus JBBDIO01
Species
Assembly information
Completeness (%) 92.25
Contamination (%) 4.17
GC content (%) 56.0
N50 (bp) 14,391
Genome size (bp) 6,328,032

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4963

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1003285_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1128.0
TLS2_k127_1003285_1 Belongs to the malate synthase family K01638 - 2.3.3.9 2.749e-255 795.0
TLS2_k127_1003285_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 543.0
TLS2_k127_1003285_3 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000001835 231.0
TLS2_k127_1003285_4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000004248 208.0
TLS2_k127_1003285_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000000000004687 157.0
TLS2_k127_1003285_7 - - - - 0.00000000000001895 80.0
TLS2_k127_1003285_8 transposition, DNA-mediated - - - 0.0000000004998 71.0
TLS2_k127_1003285_9 Lysin motif - - - 0.00000006879 60.0
TLS2_k127_1009938_0 PRC-barrel domain - - - 0.0000000000000000000003067 110.0
TLS2_k127_1009938_1 Protein of unknown function (DUF3309) - - - 0.00000000000000000506 86.0
TLS2_k127_1009938_2 AAA domain - - - 0.0000000000002116 70.0
TLS2_k127_1009938_3 peptidase K01278 - 3.4.14.5 0.0000003405 63.0
TLS2_k127_1029240_0 TIGRFAM Arsenical-resistance protein K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 509.0
TLS2_k127_1029240_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 355.0
TLS2_k127_1029240_10 Large extracellular alpha-helical protein K13735 - - 0.0000001179 61.0
TLS2_k127_1029240_11 Esterase of the alpha-beta hydrolase superfamily K07001 GO:0003674,GO:0003824,GO:0016787 - 0.00007549 48.0
TLS2_k127_1029240_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 303.0
TLS2_k127_1029240_3 - - - - 0.0000000000000000000000000000000000000000000001369 173.0
TLS2_k127_1029240_4 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.00000000000000000000000000000000005417 138.0
TLS2_k127_1029240_5 Smr domain - - - 0.0000000000000000000000000000000001616 134.0
TLS2_k127_1029240_7 response regulator - - - 0.000000000000000000000000002927 130.0
TLS2_k127_1029240_8 protein-glutamate methylesterase activity K03412,K03413,K13924 - 2.1.1.80,3.1.1.61,3.5.1.44 0.000000000000000007397 99.0
TLS2_k127_1031757_0 Alpha-L-fucosidase K01206 - 3.2.1.51 8.457e-216 676.0
TLS2_k127_1031757_1 MFS/sugar transport protein K03292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 518.0
TLS2_k127_1031757_2 Family of unknown function (DUF1028) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 367.0
TLS2_k127_1031757_3 - - - - 0.0000000000000000000000000000000000000000000000003482 188.0
TLS2_k127_1031757_4 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000002995 173.0
TLS2_k127_1031757_5 - - - - 0.000000000000000000000003131 105.0
TLS2_k127_1031757_6 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000002393 100.0
TLS2_k127_1031757_7 Phosphoesterase K07095 - - 0.000000000000003153 87.0
TLS2_k127_1050840_0 Domain of unknown function (DUF4380) - - - 0.00000000000000000000000000000000000000000000000000000000000002794 238.0
TLS2_k127_1050840_1 WD40 domain protein beta Propeller K03641 - - 0.0000000000000000000000000000000000000000000008084 177.0
TLS2_k127_1078633_0 Winged helix DNA-binding domain K09927 - - 1.56e-224 700.0
TLS2_k127_1078633_1 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 310.0
TLS2_k127_1078633_2 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000003125 222.0
TLS2_k127_1078633_3 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000001137 180.0
TLS2_k127_1078633_4 COG2335, Secreted and surface protein containing fasciclin-like repeats K01119 - 3.1.3.6,3.1.4.16 0.00000000000000000002866 105.0
TLS2_k127_1078633_5 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 GO:0003674,GO:0003824,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.4.2 0.000000000005028 68.0
TLS2_k127_1080966_0 myo-inosose-2 dehydratase activity - - - 0.000000000000000000002016 103.0
TLS2_k127_1080966_1 Peptidase_C39 like family - - - 0.00003313 52.0
TLS2_k127_1094621_0 Family 4 glycosyl hydrolase K07406 - 3.2.1.22 4.288e-230 719.0
TLS2_k127_1094621_1 Metallopeptidase family M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 544.0
TLS2_k127_1094621_2 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 512.0
TLS2_k127_1094621_3 Male sterility protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 502.0
TLS2_k127_1094621_4 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 372.0
TLS2_k127_1094621_5 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006,K01007 - 2.7.9.1,2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 332.0
TLS2_k127_1094621_6 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000368 247.0
TLS2_k127_1094621_7 transcriptional regulator - - - 0.000000000000000000000000000000000006638 140.0
TLS2_k127_1094621_8 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000006575 68.0
TLS2_k127_1094621_9 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000237 53.0
TLS2_k127_1102671_0 PFAM Prolyl oligopeptidase family - - - 3.399e-260 816.0
TLS2_k127_1102671_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 5.554e-228 717.0
TLS2_k127_1102671_2 Domain of unknown function (DUF4445) - - - 4.594e-195 634.0
TLS2_k127_1102671_3 Protein of unknown function (DUF1593) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 443.0
TLS2_k127_1102671_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 380.0
TLS2_k127_1102671_5 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 320.0
TLS2_k127_1102671_6 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000001333 193.0
TLS2_k127_1102671_7 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000000000000000000000009065 181.0
TLS2_k127_1102671_8 Virulence factor - - - 0.000000000000000004608 87.0
TLS2_k127_1106799_0 - - - - 0.0000000000000000000000000000000001488 139.0
TLS2_k127_1106799_1 PFAM NHL repeat containing protein K13735 - - 0.0000000000000000000000000000001577 141.0
TLS2_k127_1106799_2 Protein of unknown function (DUF1566) - - - 0.000000000000106 86.0
TLS2_k127_1108224_0 PFAM FAD linked oxidase domain protein K00102 - 1.1.2.4 2.692e-280 890.0
TLS2_k127_1108224_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 2.474e-210 665.0
TLS2_k127_1108224_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 526.0
TLS2_k127_1108224_3 HhH-GPD family K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 521.0
TLS2_k127_1108224_4 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 456.0
TLS2_k127_1108224_5 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 364.0
TLS2_k127_1108224_6 - - - - 0.0000000000000000000000001194 115.0
TLS2_k127_1108224_7 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0007687 52.0
TLS2_k127_1112442_0 Baseplate J-like protein - - - 8.851e-214 687.0
TLS2_k127_1112442_1 Phage tail protein (Tail_P2_I) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 524.0
TLS2_k127_1112442_10 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000002257 148.0
TLS2_k127_1112442_11 positive regulation of growth rate - - - 0.000000000000000000000000000000000001293 148.0
TLS2_k127_1112442_12 Domain of unknown function (DUF4157) - - - 0.000000000000000000000000000000000009874 153.0
TLS2_k127_1112442_13 - - - - 0.00000000000000000000000001324 126.0
TLS2_k127_1112442_2 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007202 503.0
TLS2_k127_1112442_3 Rhs Element Vgr Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002659 279.0
TLS2_k127_1112442_4 - K06905 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002744 262.0
TLS2_k127_1112442_5 Phage tail sheath protein subtilisin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001143 248.0
TLS2_k127_1112442_6 - - - - 0.00000000000000000000000000000000000000000000000000000007033 218.0
TLS2_k127_1112442_7 - - - - 0.0000000000000000000000000000000000000000000003934 186.0
TLS2_k127_1112442_8 GPW gp25 family protein K06903 - - 0.000000000000000000000000000000000000000000004928 166.0
TLS2_k127_1112442_9 - - - - 0.0000000000000000000000000000000000000001906 171.0
TLS2_k127_1114388_0 serine-type endopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 353.0
TLS2_k127_1114388_1 Belongs to the GPI family K01810 - 5.3.1.9 0.000000000000000000000000000000000003243 138.0
TLS2_k127_1114388_2 Autotransporter beta-domain - - - 0.00000000000000000000000000000004434 146.0
TLS2_k127_1114388_3 Bacterial regulatory proteins, tetR family - - - 0.00000000004876 73.0
TLS2_k127_11251_0 PFAM Neutral alkaline nonlysosomal ceramidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 398.0
TLS2_k127_11251_1 carboxylic acid catabolic process K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 376.0
TLS2_k127_11251_2 Erythromycin esterase - - - 0.000000000000000000000000000000000000000000000006528 175.0
TLS2_k127_11251_3 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000007536 178.0
TLS2_k127_11251_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000002516 124.0
TLS2_k127_11251_5 FR47-like protein - - - 0.000005085 57.0
TLS2_k127_1127256_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 1.342e-261 834.0
TLS2_k127_1127256_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 1.116e-232 759.0
TLS2_k127_1127256_2 PFAM PUCC protein K08226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 470.0
TLS2_k127_1127256_3 signal peptide processing K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000001763 253.0
TLS2_k127_1127256_5 AI-2E family transporter - - - 0.00000000000000000000000000000000000003866 162.0
TLS2_k127_1127256_7 glycolate biosynthetic process K01091 - 3.1.3.18 0.0000000000002679 83.0
TLS2_k127_1142228_0 Belongs to the carbamoyltransferase HypF family K04656 - - 1.716e-215 697.0
TLS2_k127_1142228_1 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 5.565e-202 632.0
TLS2_k127_1142228_10 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.00000000000000000000000000000009151 127.0
TLS2_k127_1142228_11 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000001314 115.0
TLS2_k127_1142228_12 von Willebrand factor type A domain K07114 - - 0.00000000000000004972 96.0
TLS2_k127_1142228_13 PFAM transposase IS4 family protein - - - 0.000000002845 59.0
TLS2_k127_1142228_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 533.0
TLS2_k127_1142228_3 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 481.0
TLS2_k127_1142228_4 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004905 466.0
TLS2_k127_1142228_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 444.0
TLS2_k127_1142228_6 Hydrogenase accessory protein HypB K03189,K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008278 262.0
TLS2_k127_1142228_8 - - - - 0.00000000000000000000000000000000000000000000000000007204 189.0
TLS2_k127_1142228_9 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.000000000000000000000000000000000000000001095 158.0
TLS2_k127_1157710_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 2.035e-217 696.0
TLS2_k127_1157710_1 4-phosphoerythronate dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 338.0
TLS2_k127_1157710_2 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 295.0
TLS2_k127_1157710_3 Belongs to the mandelate racemase muconate lactonizing enzyme family K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 297.0
TLS2_k127_1157710_4 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005248 276.0
TLS2_k127_1157710_5 PFAM Mandelate racemase muconate lactonizing enzyme K01683,K01684,K08323 - 4.2.1.5,4.2.1.6,4.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000006809 267.0
TLS2_k127_1157710_6 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000001265 212.0
TLS2_k127_1157710_7 FCD - - - 0.00000000000000000000000002798 117.0
TLS2_k127_1157710_8 solute-binding protein K02027 - - 0.000000000000000000001905 108.0
TLS2_k127_1157710_9 cytochrome P450 - - - 0.0006291 42.0
TLS2_k127_1176395_0 TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 421.0
TLS2_k127_1176395_1 domain, Protein K09766 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 330.0
TLS2_k127_1176395_2 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001509 262.0
TLS2_k127_1176395_4 heme binding K21471 - - 0.0000000000000000000000000000001896 143.0
TLS2_k127_1180373_0 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003744 620.0
TLS2_k127_1180373_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 530.0
TLS2_k127_1180373_10 Transcriptional regulator K07727 - - 0.00000000000000000000000000000001628 126.0
TLS2_k127_1180373_11 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000001958 88.0
TLS2_k127_1180373_12 Domain of unknown function (DUF1330) - - - 0.000000000002212 71.0
TLS2_k127_1180373_13 sialidase 1 (lysosomal sialidase) K01186 GO:0000323,GO:0001573,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005775,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009986,GO:0009987,GO:0010720,GO:0010975,GO:0010976,GO:0012505,GO:0016020,GO:0016042,GO:0016052,GO:0016192,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0022008,GO:0030054,GO:0030141,GO:0030149,GO:0030154,GO:0031344,GO:0031346,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032501,GO:0032502,GO:0032940,GO:0034641,GO:0034774,GO:0035580,GO:0036230,GO:0042119,GO:0042127,GO:0042581,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044422,GO:0044424,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046466,GO:0046479,GO:0046514,GO:0046903,GO:0048518,GO:0048522,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051960,GO:0051962,GO:0060205,GO:0060284,GO:0065007,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:0120035,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509,GO:2000026,GO:2000291 3.2.1.18 0.000000005943 63.0
TLS2_k127_1180373_14 DDE_Tnp_1-associated - - - 0.000001504 53.0
TLS2_k127_1180373_2 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006752 509.0
TLS2_k127_1180373_3 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 332.0
TLS2_k127_1180373_4 EcsC protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000124 255.0
TLS2_k127_1180373_5 Putative integral membrane protein (DUF2391) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001836 250.0
TLS2_k127_1180373_6 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000003398 229.0
TLS2_k127_1180373_7 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000249 228.0
TLS2_k127_1180373_8 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000002303 185.0
TLS2_k127_1180373_9 - - - - 0.00000000000000000000000000000000000000000007035 178.0
TLS2_k127_1187023_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004881 375.0
TLS2_k127_1187023_1 Domain of unknown function (DUF4350) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001728 250.0
TLS2_k127_1187023_2 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - 0.000000000000000000000000000000000000000001012 172.0
TLS2_k127_1187023_3 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000002121 157.0
TLS2_k127_1187023_4 Domain of unknown function (DUF4129) - - - 0.00000000000000000001689 105.0
TLS2_k127_1210494_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 437.0
TLS2_k127_1210494_1 Converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 431.0
TLS2_k127_1210494_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 397.0
TLS2_k127_1210494_3 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000003351 199.0
TLS2_k127_1210494_4 Serine aminopeptidase, S33 - - - 0.000000000000000000000000004355 120.0
TLS2_k127_1230400_0 PFAM ComEC Rec2-related protein K02238 - - 6.717e-246 788.0
TLS2_k127_1230400_1 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 3.872e-235 743.0
TLS2_k127_1230400_10 PFAM Cold-shock K03704 - - 0.0000000000000000000000001438 107.0
TLS2_k127_1230400_11 PFAM Rhodopirellula transposase family protein - - - 0.000000000000000000000000271 111.0
TLS2_k127_1230400_12 COG0563 Adenylate kinase and related kinases - - - 0.00000000002106 71.0
TLS2_k127_1230400_13 DinB superfamily - - - 0.00000000007315 63.0
TLS2_k127_1230400_14 Rhodopirellula transposase DDE domain - - - 0.00000174 51.0
TLS2_k127_1230400_2 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 3.31e-212 676.0
TLS2_k127_1230400_3 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007626 442.0
TLS2_k127_1230400_4 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 429.0
TLS2_k127_1230400_5 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006975 426.0
TLS2_k127_1230400_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 425.0
TLS2_k127_1230400_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 400.0
TLS2_k127_1230400_8 ABC-type transport system, permease components - - - 0.0000000000000000000000000000000000000000000000000000002717 200.0
TLS2_k127_1230400_9 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000168 118.0
TLS2_k127_123556_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1349.0
TLS2_k127_123556_1 Heat shock 70 kDa protein K04043 - - 0.0 1017.0
TLS2_k127_123556_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002037 250.0
TLS2_k127_123556_11 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000009889 192.0
TLS2_k127_123556_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000006817 182.0
TLS2_k127_123556_13 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582 - - 0.00000000000000000000000000000000000000000000003612 172.0
TLS2_k127_123556_14 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000001454 172.0
TLS2_k127_123556_2 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.681e-270 839.0
TLS2_k127_123556_3 lipolytic protein G-D-S-L family - - - 3.215e-229 753.0
TLS2_k127_123556_4 peptidase dimerisation domain protein K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 508.0
TLS2_k127_123556_5 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 513.0
TLS2_k127_123556_6 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 403.0
TLS2_k127_123556_7 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 388.0
TLS2_k127_123556_8 Heat shock protein DnaJ domain protein K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 386.0
TLS2_k127_1238499_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 5.179e-260 812.0
TLS2_k127_1238499_1 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 611.0
TLS2_k127_1238499_10 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 298.0
TLS2_k127_1238499_11 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 304.0
TLS2_k127_1238499_12 COGs COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002301 284.0
TLS2_k127_1238499_13 cell adhesion involved in biofilm formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003433 299.0
TLS2_k127_1238499_14 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000003005 188.0
TLS2_k127_1238499_15 Sh3 type 3 domain protein K03642,K07184 - - 0.00000000000000000005681 103.0
TLS2_k127_1238499_16 S4 domain protein K14761 - - 0.00000000000000001548 85.0
TLS2_k127_1238499_2 PFAM Rh family protein ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 556.0
TLS2_k127_1238499_3 Protein of unknown function (DUF2723) K14340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 535.0
TLS2_k127_1238499_4 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009738 497.0
TLS2_k127_1238499_5 response to stress - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 465.0
TLS2_k127_1238499_6 Protein of unknown function (DUF1385) K09153 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 460.0
TLS2_k127_1238499_7 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 404.0
TLS2_k127_1238499_8 TIGRFAM sulfate adenylyltransferase, small subunit K00957 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 390.0
TLS2_k127_1238499_9 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 384.0
TLS2_k127_1251037_0 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 1.33e-293 922.0
TLS2_k127_1251037_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 486.0
TLS2_k127_1251037_2 AMP-binding enzyme C-terminal domain K18660,K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 406.0
TLS2_k127_1251037_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 398.0
TLS2_k127_1251037_4 PFAM Sulfotransferase K01014 - 2.8.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 309.0
TLS2_k127_1251037_5 PFAM glutamine amidotransferase class-I K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 306.0
TLS2_k127_1251037_6 COG NOG14600 non supervised orthologous group - - - 0.000000000000000000000001165 104.0
TLS2_k127_1251037_7 Transposase and inactivated derivatives, TnpA family - - - 0.0000000000000936 75.0
TLS2_k127_1257266_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 9.412e-232 729.0
TLS2_k127_1257266_1 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 465.0
TLS2_k127_1257266_11 peptidase K21471 - - 0.000000000003578 79.0
TLS2_k127_1257266_2 D-mannonate dehydratase (UxuA) K01686 - 4.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 390.0
TLS2_k127_1257266_3 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005674 347.0
TLS2_k127_1257266_4 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002978 247.0
TLS2_k127_1257266_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000001971 203.0
TLS2_k127_1257266_6 Dihydrodipicolinate synthetase family K13876 - 4.2.1.43 0.000000000000000000000000000000000000000000000002333 184.0
TLS2_k127_1257266_7 lactoylglutathione lyase activity K08234 - - 0.0000000000000000000000000000000000001576 144.0
TLS2_k127_1257266_9 mandelate racemase muconate lactonizing - - - 0.00000000000000000000000000007631 118.0
TLS2_k127_1262067_0 protein secretion K07114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0 2125.0
TLS2_k127_1262067_1 lipolytic protein G-D-S-L family - - - 0.0 1459.0
TLS2_k127_1281339_0 Domain of unknown function (DUF2088) K22373 - 5.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008174 425.0
TLS2_k127_1281339_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009987 315.0
TLS2_k127_1281339_2 dioxygenase activity K18565 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 306.0
TLS2_k127_1281339_3 Oxidoreductase family, NAD-binding Rossmann fold K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000004807 189.0
TLS2_k127_1281339_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000005564 164.0
TLS2_k127_1281339_5 Cupin 2, conserved barrel domain protein - - - 0.00002808 55.0
TLS2_k127_1285418_0 COG4813 Trehalose utilization protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 358.0
TLS2_k127_1285418_1 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 323.0
TLS2_k127_1285418_2 Protein of unknown function (DUF3048) C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002213 244.0
TLS2_k127_1285418_3 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000000000000199 164.0
TLS2_k127_1285418_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000001773 82.0
TLS2_k127_1285418_5 sh3 domain protein - - - 0.00000006688 65.0
TLS2_k127_1285418_8 Peptidase family M50 K06212,K06402 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0002547 45.0
TLS2_k127_1286104_0 Belongs to the CarA family K01956 - 6.3.5.5 3.94e-204 644.0
TLS2_k127_1286104_1 TIGRFAM acetylornithine and succinylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 591.0
TLS2_k127_1286104_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007607 488.0
TLS2_k127_1286104_3 serine-type endopeptidase activity K08070,K08372 - 1.3.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 469.0
TLS2_k127_1286104_4 helix_turn_helix, Lux Regulon K03556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 428.0
TLS2_k127_1286104_5 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 392.0
TLS2_k127_1286104_6 Carbon-nitrogen hydrolase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005279 291.0
TLS2_k127_1286104_7 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002912 261.0
TLS2_k127_1286104_9 - - - - 0.00000004023 57.0
TLS2_k127_128743_0 cystathionine gamma-synthase activity K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 483.0
TLS2_k127_128743_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009462 386.0
TLS2_k127_1287967_0 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008413 246.0
TLS2_k127_1287967_1 ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - 0.0000000000000000000000000000000000000000008244 161.0
TLS2_k127_1287967_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000006526 124.0
TLS2_k127_1289957_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 2.689e-291 909.0
TLS2_k127_1289957_1 PHP domain protein K02347 - - 2.882e-239 754.0
TLS2_k127_1289957_10 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K01919,K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 387.0
TLS2_k127_1289957_11 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 373.0
TLS2_k127_1289957_12 Alcohol dehydrogenase GroES domain protein K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 370.0
TLS2_k127_1289957_13 PFAM conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008001 367.0
TLS2_k127_1289957_14 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 350.0
TLS2_k127_1289957_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 329.0
TLS2_k127_1289957_16 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000188 289.0
TLS2_k127_1289957_17 nucleoside hydrolase K01250,K12700 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001047 254.0
TLS2_k127_1289957_18 spermidine putrescine ABC transporter, permease K02025,K17238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001537 248.0
TLS2_k127_1289957_19 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001731 252.0
TLS2_k127_1289957_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756,K01857 - 4.3.2.2,5.5.1.2 8.177e-215 676.0
TLS2_k127_1289957_20 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000000002292 237.0
TLS2_k127_1289957_21 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000001 233.0
TLS2_k127_1289957_22 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000001296 227.0
TLS2_k127_1289957_23 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000006362 203.0
TLS2_k127_1289957_24 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000001706 202.0
TLS2_k127_1289957_25 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000001654 143.0
TLS2_k127_1289957_26 Rdx family K07401 - - 0.0000000000000000000003479 108.0
TLS2_k127_1289957_27 Phage integrase family - - - 0.000000000000007109 82.0
TLS2_k127_1289957_28 Methyltransferase domain - - - 0.00000000000001178 85.0
TLS2_k127_1289957_29 ThiS family K03636,K21142 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.12 0.000000002199 67.0
TLS2_k127_1289957_3 Iron-containing alcohol dehydrogenase K11173 - 1.1.99.24 8.048e-206 647.0
TLS2_k127_1289957_4 MoeA domain protein domain I and II K03750,K15376 - 2.10.1.1,2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 528.0
TLS2_k127_1289957_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 518.0
TLS2_k127_1289957_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 439.0
TLS2_k127_1289957_7 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 400.0
TLS2_k127_1289957_8 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 389.0
TLS2_k127_1289957_9 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 385.0
TLS2_k127_1301995_0 PFAM NAD-dependent epimerase dehydratase K06118 - 3.13.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 595.0
TLS2_k127_1301995_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 529.0
TLS2_k127_1301995_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 532.0
TLS2_k127_1301995_3 NADPH quinone reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 485.0
TLS2_k127_1301995_4 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 450.0
TLS2_k127_1301995_5 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 448.0
TLS2_k127_1301995_6 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003724 396.0
TLS2_k127_1301995_7 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000000007771 225.0
TLS2_k127_1301995_8 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000001933 183.0
TLS2_k127_1306446_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1131.0
TLS2_k127_1306446_1 PFAM RNA binding S1 domain protein K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 546.0
TLS2_k127_1306446_10 MOSC domain - - - 0.0000000000000000000000000000000000000000000000003224 182.0
TLS2_k127_1306446_11 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000000000000000000000000000002575 179.0
TLS2_k127_1306446_12 PFAM DinB family protein - - - 0.000000000000000000000000000000000000000004093 160.0
TLS2_k127_1306446_13 GDP-mannose mannosyl hydrolase activity - - - 0.0000000000000000000000000000000000000001548 155.0
TLS2_k127_1306446_14 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000001436 138.0
TLS2_k127_1306446_15 Ribosomal protein S21 K02970 - - 0.00000000000000000000001402 100.0
TLS2_k127_1306446_16 - - - - 0.0000000000000092 77.0
TLS2_k127_1306446_17 - - - - 0.000000000001035 76.0
TLS2_k127_1306446_18 tyrosine recombinase XerC K03733,K04763 - - 0.00000263 54.0
TLS2_k127_1306446_2 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 471.0
TLS2_k127_1306446_3 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 440.0
TLS2_k127_1306446_5 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 316.0
TLS2_k127_1306446_6 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 305.0
TLS2_k127_1306446_7 iron dependent repressor K03709 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 297.0
TLS2_k127_1306446_8 synthase K16167 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001344 283.0
TLS2_k127_1306446_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000006794 220.0
TLS2_k127_1320624_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 1.039e-319 990.0
TLS2_k127_1320624_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 518.0
TLS2_k127_1320624_2 Catalytic domain of components of various dehydrogenase complexes K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 382.0
TLS2_k127_1320624_3 Scaffold protein Nfu/NifU N terminal - - - 0.0000000000002331 74.0
TLS2_k127_1320624_4 PFAM amine oxidase - - - 0.000000000549 60.0
TLS2_k127_1352951_0 elongation factor Tu domain 2 protein K06207 - - 1.506e-289 903.0
TLS2_k127_1352951_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 1.704e-237 740.0
TLS2_k127_1352951_10 - - - - 0.00000004912 64.0
TLS2_k127_1352951_12 Cellulose synthase operon protein C C-terminus (BCSC_C) K20543 - - 0.0001398 49.0
TLS2_k127_1352951_2 Amidohydrolase family - - - 3.267e-235 741.0
TLS2_k127_1352951_3 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 543.0
TLS2_k127_1352951_4 PFAM DNA methylase N-4 N-6 domain protein K00571,K07316 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 533.0
TLS2_k127_1352951_5 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 384.0
TLS2_k127_1352951_6 tRNA (guanine-N7-)-methyltransferase activity K02493,K02527,K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 376.0
TLS2_k127_1352951_7 electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 301.0
TLS2_k127_1352951_8 Beta-lactamase enzyme family - - - 0.000000000000000000000000000000000000000000000001248 185.0
TLS2_k127_1352951_9 enoyl-[acyl-carrier-protein] reductase (NADH) activity - - - 0.00000000000000000000000000000000000214 143.0
TLS2_k127_1372199_0 Psort location CytoplasmicMembrane, score - - - 1.003e-234 751.0
TLS2_k127_1372199_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 531.0
TLS2_k127_1372199_2 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 388.0
TLS2_k127_1372199_3 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 372.0
TLS2_k127_1372199_4 acetyltransferase K06323 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006824 259.0
TLS2_k127_1372199_5 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000000000000000000000000000000009999 199.0
TLS2_k127_1372199_6 AMP binding - - - 0.000000000000000000000000000000004896 139.0
TLS2_k127_1372199_8 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000005543 51.0
TLS2_k127_1382176_0 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 580.0
TLS2_k127_1382176_1 PFAM GHMP kinase K07031 - 2.7.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 469.0
TLS2_k127_1382176_2 PFAM monooxygenase FAD-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 451.0
TLS2_k127_1382176_3 PFAM lipopolysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009707 401.0
TLS2_k127_1382176_4 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000002248 200.0
TLS2_k127_1382176_5 Histidinol-phosphate phosphatase family protein K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000001143 192.0
TLS2_k127_1382176_6 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000001511 192.0
TLS2_k127_1382176_7 nucleoside hydrolase - - - 0.00000000000000000000000000000000000002853 162.0
TLS2_k127_1382176_8 protein secretion K01113,K20274 - 3.1.3.1 0.000000001238 71.0
TLS2_k127_1382176_9 Multicopper oxidase K08100 - 1.3.3.5 0.0009772 47.0
TLS2_k127_1409163_0 Membrane - - - 7.323e-252 799.0
TLS2_k127_1409163_1 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 1.227e-232 724.0
TLS2_k127_1409163_10 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005032 252.0
TLS2_k127_1409163_11 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000000000000000005972 249.0
TLS2_k127_1409163_13 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000002079 203.0
TLS2_k127_1409163_14 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000008457 203.0
TLS2_k127_1409163_15 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000008402 178.0
TLS2_k127_1409163_16 molybdopterin cofactor binding K07402 - - 0.00000000000000000000000000000000000000000003931 164.0
TLS2_k127_1409163_17 FR47-like protein - - - 0.0000000000000000000000000000000000000000000705 168.0
TLS2_k127_1409163_18 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.000000000000000000000000000000002811 136.0
TLS2_k127_1409163_19 MazG-like family - - - 0.00000000000000000000001846 104.0
TLS2_k127_1409163_2 Belongs to the argininosuccinate synthase family. Type K01940 - 6.3.4.5 7.695e-230 717.0
TLS2_k127_1409163_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 1.877e-219 704.0
TLS2_k127_1409163_4 Domain of unknown function (DUF368) K08974 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 397.0
TLS2_k127_1409163_5 hydroxyacid-oxoacid transhydrogenase activity K00001,K01714 - 1.1.1.1,4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 393.0
TLS2_k127_1409163_6 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 366.0
TLS2_k127_1409163_7 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 306.0
TLS2_k127_1409163_8 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 305.0
TLS2_k127_1409163_9 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 302.0
TLS2_k127_1418064_0 Molybdopterin oxidoreductase - - - 0.0 1638.0
TLS2_k127_1418064_1 nitrate reductase beta subunit K00371,K16965,K17048,K17051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 6.601e-245 759.0
TLS2_k127_1418064_10 response regulator - - - 0.0000000000000000000000000000000000000000000000001731 185.0
TLS2_k127_1418064_11 RNA polymerase II activating transcription factor binding - - - 0.0000000000000000000000000000000000000000000000037 201.0
TLS2_k127_1418064_12 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000003408 152.0
TLS2_k127_1418064_13 COG3850 Signal transduction histidine kinase, nitrate nitrite-specific K07673 - 2.7.13.3 0.0000000000000000000000000001995 131.0
TLS2_k127_1418064_14 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000001391 101.0
TLS2_k127_1418064_15 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K00387 - 1.8.3.1 0.00008193 51.0
TLS2_k127_1418064_16 helix_turn_helix, Lux Regulon - - - 0.0003329 49.0
TLS2_k127_1418064_2 transcriptional activator domain - - - 2.155e-244 792.0
TLS2_k127_1418064_3 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 354.0
TLS2_k127_1418064_4 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 337.0
TLS2_k127_1418064_5 protein complex oligomerization - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004938 282.0
TLS2_k127_1418064_7 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000007225 254.0
TLS2_k127_1418064_8 SPTR CHU large protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008538 286.0
TLS2_k127_1418064_9 SdrD B-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008505 263.0
TLS2_k127_1422087_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 3.423e-239 755.0
TLS2_k127_1422087_1 Cytochrome b(N-terminal)/b6/petB K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000006537 237.0
TLS2_k127_1422087_2 PFAM Rieske 2Fe-2S domain protein - - - 0.0000000000000000000000000000000000000000000000001322 184.0
TLS2_k127_1422087_3 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000008459 160.0
TLS2_k127_1422087_4 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000007735 72.0
TLS2_k127_1423503_0 PFAM Adenosine AMP deaminase K01488,K18286 - 3.5.4.4,3.5.4.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 440.0
TLS2_k127_1423503_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 372.0
TLS2_k127_1423503_2 transcriptional regulator K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 340.0
TLS2_k127_1423503_3 sugar fermentation stimulation protein K06206 - - 0.000000000000000000000000000000000000000000000001472 183.0
TLS2_k127_1423503_4 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000002992 113.0
TLS2_k127_1428743_0 histidine kinase, dimerisation and phosphoacceptor region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 366.0
TLS2_k127_1428743_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 310.0
TLS2_k127_1428743_10 PFAM regulator of chromosome condensation, RCC1 - - - 0.0000000006291 61.0
TLS2_k127_1428743_11 bacterial-type flagellum-dependent cell motility K20951,K20952 - - 0.00000002158 65.0
TLS2_k127_1428743_12 PFAM regulator of chromosome condensation, RCC1 - - - 0.0003314 43.0
TLS2_k127_1428743_13 Endothelial cell-specific molecule 1 - GO:0001525,GO:0001568,GO:0001944,GO:0002040,GO:0003674,GO:0005102,GO:0005171,GO:0005178,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0007275,GO:0008150,GO:0008284,GO:0009653,GO:0009966,GO:0009967,GO:0010646,GO:0010647,GO:0023051,GO:0023056,GO:0032501,GO:0032502,GO:0035239,GO:0035295,GO:0042127,GO:0044877,GO:0048514,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0048646,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050839,GO:0065007,GO:0070851,GO:0072358,GO:0072359,GO:1902202,GO:1902204 - 0.0009593 44.0
TLS2_k127_1428743_2 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001383 278.0
TLS2_k127_1428743_3 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000005466 261.0
TLS2_k127_1428743_5 PFAM transposase, IS4 family protein - - - 0.000000000000000000000000000000000000000000000000003701 186.0
TLS2_k127_1428743_7 Protein of unknown function (DUF2442) - - - 0.000000000000000000004349 95.0
TLS2_k127_1428743_8 bacterial-type flagellum-dependent cell motility K20951,K20952 - - 0.000000000000000261 87.0
TLS2_k127_14610_0 Erythromycin esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 520.0
TLS2_k127_14610_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005984 493.0
TLS2_k127_14610_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 357.0
TLS2_k127_14610_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 357.0
TLS2_k127_14610_4 - - - - 0.00000000000000000000000000000000000000006054 155.0
TLS2_k127_14610_5 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000004356 152.0
TLS2_k127_14610_6 DNA-binding transcription factor activity K03892 - - 0.0000000000000000000000000000000005344 136.0
TLS2_k127_14610_7 - - - - 0.0000000000000002376 81.0
TLS2_k127_14610_8 PFAM Pentapeptide repeats (8 copies) - - - 0.000000002826 63.0
TLS2_k127_1461965_0 Dehydratase family - - - 6.747e-265 829.0
TLS2_k127_1461965_1 helix_turn_helix, Lux Regulon K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 600.0
TLS2_k127_1461965_10 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009512 249.0
TLS2_k127_1461965_11 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000861 232.0
TLS2_k127_1461965_12 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000001106 222.0
TLS2_k127_1461965_13 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000000000000000000002304 188.0
TLS2_k127_1461965_14 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000000000000000000000002557 178.0
TLS2_k127_1461965_15 YtkA-like - - - 0.0000000000000000000000000000000000000000000006662 170.0
TLS2_k127_1461965_16 Anion-transporting ATPase - - - 0.000000000000000000006651 96.0
TLS2_k127_1461965_2 electron transfer activity K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 511.0
TLS2_k127_1461965_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 470.0
TLS2_k127_1461965_4 mandelate racemase muconate lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 453.0
TLS2_k127_1461965_5 PFAM transposase, mutator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 427.0
TLS2_k127_1461965_6 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 395.0
TLS2_k127_1461965_7 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 314.0
TLS2_k127_1461965_8 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 291.0
TLS2_k127_1461965_9 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006683 252.0
TLS2_k127_1464041_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 3.796e-197 629.0
TLS2_k127_1464041_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K12661 - 4.2.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006154 501.0
TLS2_k127_1464041_10 Belongs to the sulfur carrier protein TusA family - GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.000000001415 61.0
TLS2_k127_1464041_2 Rhodanese Homology Domain K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001004 259.0
TLS2_k127_1464041_3 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000001846 237.0
TLS2_k127_1464041_4 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000003305 222.0
TLS2_k127_1464041_5 PFAM OsmC family protein K04063 - - 0.000000000000000000000000000000000000000000000000000000004072 201.0
TLS2_k127_1464041_6 M42 glutamyl aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000003811 195.0
TLS2_k127_1464041_7 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000001967 123.0
TLS2_k127_1464041_8 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000009885 114.0
TLS2_k127_1464041_9 Xylose isomerase-like TIM barrel - - - 0.0000000000001521 80.0
TLS2_k127_1473261_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 394.0
TLS2_k127_1473261_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K05299 - 1.17.1.10,1.17.1.9 0.00000000000000000000000000000000000000000000000004974 182.0
TLS2_k127_1473261_2 NADH ubiquinone oxidoreductase K22338 - 1.17.1.11 0.0000000000000000000000000000000000000000003192 166.0
TLS2_k127_1473261_3 Molybdopterin oxidoreductase K00123 - 1.17.1.9 0.000000000000000000000000000000000000405 145.0
TLS2_k127_1474903_0 beta-fructofuranosidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 493.0
TLS2_k127_1474903_1 beta-fructofuranosidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009841 347.0
TLS2_k127_1474903_2 Acetyltransferase - - - 0.000000035 65.0
TLS2_k127_1474903_3 Creatinase/Prolidase N-terminal domain - - - 0.000007433 56.0
TLS2_k127_1484369_0 serine-type peptidase activity - - - 9.013e-198 625.0
TLS2_k127_1484369_1 Belongs to the mandelate racemase muconate lactonizing enzyme family K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 509.0
TLS2_k127_1484369_10 2-keto-3-deoxy-L-rhamnonate aldolase activity K02510 - 4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000004725 226.0
TLS2_k127_1484369_11 DNA-binding transcription factor activity K03710 - - 0.00000000000000000000000000000000000000000000000000000000000001362 224.0
TLS2_k127_1484369_12 family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000004697 235.0
TLS2_k127_1484369_13 ROK family - - - 0.0000000000000000000000000000000000000000000000000000000003399 218.0
TLS2_k127_1484369_14 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000003254 199.0
TLS2_k127_1484369_15 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000253 157.0
TLS2_k127_1484369_16 Transposase - - - 0.000000000000000000000000000005415 128.0
TLS2_k127_1484369_17 beta-fructofuranosidase activity - - - 0.0000000000000000000003648 111.0
TLS2_k127_1484369_18 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000001968 78.0
TLS2_k127_1484369_19 Bacterial extracellular solute-binding protein K05813 - - 0.0000000000003359 82.0
TLS2_k127_1484369_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 500.0
TLS2_k127_1484369_21 PFAM transposase IS3 IS911 family protein K07483 - - 0.000001603 56.0
TLS2_k127_1484369_22 PFAM transposase, IS4 family protein - - - 0.0001122 52.0
TLS2_k127_1484369_3 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007302 333.0
TLS2_k127_1484369_4 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 326.0
TLS2_k127_1484369_5 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 321.0
TLS2_k127_1484369_6 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 316.0
TLS2_k127_1484369_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004733 309.0
TLS2_k127_1484369_8 glycerophosphodiester transmembrane transport K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008811 269.0
TLS2_k127_1484369_9 HpcH/HpaI aldolase/citrate lyase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000009056 241.0
TLS2_k127_1487462_0 Molybdopterin-binding domain of aldehyde dehydrogenase - - - 2.167e-206 667.0
TLS2_k127_1487462_1 Sodium/hydrogen exchanger family K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 518.0
TLS2_k127_1487462_2 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 432.0
TLS2_k127_1487462_3 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000000000000000000000004674 213.0
TLS2_k127_1487462_4 Domain of unknown function (DUF1980) - - - 0.000000000000000000000000000000000000000000000007 179.0
TLS2_k127_1487462_5 [2Fe-2S] binding domain K18029 - 1.17.2.1 0.0000000000002089 71.0
TLS2_k127_1487462_6 Xylose isomerase domain protein TIM barrel - - - 0.0000006172 60.0
TLS2_k127_149175_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 4.888e-211 669.0
TLS2_k127_149175_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 542.0
TLS2_k127_149175_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 450.0
TLS2_k127_149175_3 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 426.0
TLS2_k127_149175_4 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 361.0
TLS2_k127_149175_5 PFAM Dimethylmenaquinone methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 352.0
TLS2_k127_149175_6 - K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005919 359.0
TLS2_k127_149175_7 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 319.0
TLS2_k127_149175_8 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 295.0
TLS2_k127_149175_9 Predicted integral membrane protein (DUF2269) - - - 0.00001012 54.0
TLS2_k127_1497212_0 SMART Elongator protein 3 MiaB NifB - - - 6.027e-313 963.0
TLS2_k127_1497212_1 ABC transporter K01990,K09689,K09691 - 3.6.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 463.0
TLS2_k127_1497212_2 PFAM ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 358.0
TLS2_k127_1497212_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005259 338.0
TLS2_k127_1497212_4 O-antigen ligase like membrane protein - - - 0.00000000000000000000000000000000000000000000000000006193 208.0
TLS2_k127_1497212_5 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000002059 140.0
TLS2_k127_1497212_6 EamA-like transporter family - - - 0.00000000000000000000002184 104.0
TLS2_k127_1512500_0 Glycosyltransferase Family 4 K15521 - 2.4.1.250 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 491.0
TLS2_k127_1512500_1 PFAM LmbE family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000004658 237.0
TLS2_k127_1512500_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K07025,K20866 - 3.1.3.10 0.0000000000000000000000000000002953 130.0
TLS2_k127_1523193_0 COG3119 Arylsulfatase A and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 578.0
TLS2_k127_1523193_1 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005347 368.0
TLS2_k127_1523193_2 Lactonase, 7-bladed beta-propeller K07404 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 363.0
TLS2_k127_1523193_3 mannose-ethanolamine phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000009948 221.0
TLS2_k127_1523193_4 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000001278 214.0
TLS2_k127_1523193_5 Glycerophosphoryl diester phosphodiesterase family - - - 0.0000000000000000000000000000000000000000000000000000005985 203.0
TLS2_k127_1523193_6 phosphatase activity K07025,K20862 - 3.1.3.102,3.1.3.104 0.000000000000000000000000000007288 122.0
TLS2_k127_1550355_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0 1120.0
TLS2_k127_1550355_1 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 595.0
TLS2_k127_1550355_10 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000205 189.0
TLS2_k127_1550355_11 - - - - 0.00000000000000000000000000000000001183 144.0
TLS2_k127_1550355_12 PFAM ABC transporter related K06158 - - 0.000000000001977 67.0
TLS2_k127_1550355_13 Lysin motif - - - 0.000000000007934 78.0
TLS2_k127_1550355_2 Glycosyl transferase family group 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 520.0
TLS2_k127_1550355_3 AIR synthase related protein, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 412.0
TLS2_k127_1550355_4 LysM domain K21449,K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 381.0
TLS2_k127_1550355_5 lysyltransferase activity K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 370.0
TLS2_k127_1550355_6 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin K14645,K17734 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 373.0
TLS2_k127_1550355_7 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 296.0
TLS2_k127_1550355_8 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000001364 250.0
TLS2_k127_1550355_9 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000000000000000000000000001009 232.0
TLS2_k127_1550810_0 Bacterial extracellular solute-binding protein K15770 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 609.0
TLS2_k127_1550810_1 transmembrane transport K02025,K05814,K10109,K10118,K10237,K10241,K15771,K17235,K17242,K17316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 477.0
TLS2_k127_1550810_2 PFAM binding-protein-dependent transport systems inner membrane component K15772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 462.0
TLS2_k127_1550810_3 transmembrane transport K02025,K05814,K10109,K10118,K10237,K10241,K15771,K17235,K17242,K17316 GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000002051 234.0
TLS2_k127_1550810_4 Protein of unknown function (DUF1706) - - - 0.000000000008429 70.0
TLS2_k127_1550810_5 Cysteine-rich secretory protein family - - - 0.00000000002488 70.0
TLS2_k127_1553851_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0 1313.0
TLS2_k127_1553851_1 deoxyhypusine monooxygenase activity - - - 0.0000000000001097 82.0
TLS2_k127_1566966_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.401e-221 692.0
TLS2_k127_1566966_1 Peptidase dimerisation domain - - - 1.57e-204 642.0
TLS2_k127_1566966_10 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 301.0
TLS2_k127_1566966_11 protein, homolog of Cu resistance protein CopC K07245,K14166 - - 0.000000000000000000000000000000000000000000000000000000000001155 233.0
TLS2_k127_1566966_13 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000006776 181.0
TLS2_k127_1566966_14 - - - - 0.0000000000000000000005242 99.0
TLS2_k127_1566966_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.00000000000164 81.0
TLS2_k127_1566966_2 COGs COG1653 ABC-type sugar transport system periplasmic component K02027 - - 5.269e-199 629.0
TLS2_k127_1566966_3 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17242,K17316 - - 3.107e-194 621.0
TLS2_k127_1566966_5 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 460.0
TLS2_k127_1566966_6 glycerophosphodiester transmembrane transport K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 457.0
TLS2_k127_1566966_7 PFAM Cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 387.0
TLS2_k127_1566966_8 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 382.0
TLS2_k127_1566966_9 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000888 331.0
TLS2_k127_1578774_0 PFAM Methicillin resistance protein - - - 1.693e-265 840.0
TLS2_k127_1578774_1 PFAM oxidoreductase domain protein - - - 2.431e-218 685.0
TLS2_k127_1578774_10 Sh3 type 3 domain protein K01448,K07448 - 3.5.1.28 0.0000000000000000000000000000000000000000000209 168.0
TLS2_k127_1578774_11 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000001525 110.0
TLS2_k127_1578774_2 Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 588.0
TLS2_k127_1578774_3 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009177 392.0
TLS2_k127_1578774_4 Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 381.0
TLS2_k127_1578774_5 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 369.0
TLS2_k127_1578774_6 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005037 333.0
TLS2_k127_1578774_7 Mate efflux family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000951 333.0
TLS2_k127_1578774_8 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006278 246.0
TLS2_k127_1578774_9 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001246 247.0
TLS2_k127_1624103_0 COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 495.0
TLS2_k127_1624103_1 acetamidase formamidase K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 436.0
TLS2_k127_1624103_10 4-vinyl reductase, 4VR - - - 0.0000000000000000000000000000000000000000458 158.0
TLS2_k127_1624103_11 PFAM Dual specificity protein phosphatase - - - 0.00000000000000000000000000000000000000007926 158.0
TLS2_k127_1624103_12 Phosphorylase superfamily K00772 - 2.4.2.28 0.000000000000000000000000000003499 131.0
TLS2_k127_1624103_13 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000001198 130.0
TLS2_k127_1624103_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007646 429.0
TLS2_k127_1624103_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 372.0
TLS2_k127_1624103_4 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 303.0
TLS2_k127_1624103_5 diacylglycerol kinase, catalytic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000021 246.0
TLS2_k127_1624103_6 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000007371 221.0
TLS2_k127_1624103_7 PFAM ABC transporter related K02049 - - 0.0000000000000000000000000000000000000000000000000000000000008115 220.0
TLS2_k127_1624103_8 FGGY family of carbohydrate kinases, N-terminal domain K11214 - 2.7.1.14 0.0000000000000000000000000000000000000000000000000000678 199.0
TLS2_k127_1624103_9 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000003482 187.0
TLS2_k127_1634803_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 464.0
TLS2_k127_1634803_1 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 437.0
TLS2_k127_1634803_2 PFAM PDZ DHR GLGF domain protein K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000008329 252.0
TLS2_k127_1673996_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1642.0
TLS2_k127_1673996_1 Sterol carrier protein - - - 0.0002068 53.0
TLS2_k127_1674478_0 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 363.0
TLS2_k127_1674478_1 4-phosphoerythronate dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 335.0
TLS2_k127_1674478_2 Domain of unknown function (DUF4395) - - - 0.00000000000000000000000000000000000000000002713 166.0
TLS2_k127_1674478_3 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000008293 156.0
TLS2_k127_1674478_4 COG0526, thiol-disulfide isomerase and thioredoxins K03671 - - 0.0000000000000000000000006488 109.0
TLS2_k127_1675102_0 Putative glucoamylase K13688 - - 1.737e-207 681.0
TLS2_k127_1675102_1 Universal stress protein family - - - 0.0000000000000000001481 102.0
TLS2_k127_1675178_0 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 387.0
TLS2_k127_1675178_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 366.0
TLS2_k127_1675178_2 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000001209 202.0
TLS2_k127_1675178_3 endoribonuclease L-PSP - - - 0.00000000000000000000000000000000018 137.0
TLS2_k127_1675178_4 cellulase activity - - - 0.00000007594 61.0
TLS2_k127_1675178_5 Extracellular solute-binding protein, family 5 K02035 - - 0.000006107 49.0
TLS2_k127_1705366_0 PFAM cell divisionFtsK SpoIIIE K03466 GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009439 453.0
TLS2_k127_1705366_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 298.0
TLS2_k127_1705366_2 Phosphoribosyl transferase domain K07101 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006968 275.0
TLS2_k127_1705366_4 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.00000000000000000000001178 109.0
TLS2_k127_1705366_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000004329 98.0
TLS2_k127_172586_0 Belongs to the thiolase family K00626 - 2.3.1.9 4.586e-209 654.0
TLS2_k127_172586_1 PFAM AAA-4 family protein K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 610.0
TLS2_k127_172586_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 531.0
TLS2_k127_172586_3 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 447.0
TLS2_k127_1731686_0 Iron-sulfur cluster-binding domain - - - 1.808e-213 665.0
TLS2_k127_1731686_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 428.0
TLS2_k127_1731686_2 Putative restriction endonuclease - - - 0.00000000000000000000000000000003141 133.0
TLS2_k127_1736123_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 7.167e-275 858.0
TLS2_k127_1736123_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.97e-233 735.0
TLS2_k127_1736123_2 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 2.915e-232 733.0
TLS2_k127_1736123_3 PFAM cytoplasmic peptidoglycan synthetase domain protein K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 574.0
TLS2_k127_1736123_4 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 368.0
TLS2_k127_1736123_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 347.0
TLS2_k127_1736123_6 molybdenum cofactor guanylyltransferase activity K03752,K13818 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.77 0.0000000000000000000000000000001587 138.0
TLS2_k127_1736123_7 phosphatidate phosphatase activity K01096,K19302 - 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.00000000000001548 82.0
TLS2_k127_176387_0 PFAM type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 539.0
TLS2_k127_176387_1 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 556.0
TLS2_k127_176387_2 Probable transposase K07496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 340.0
TLS2_k127_176387_3 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000005303 103.0
TLS2_k127_1782656_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 389.0
TLS2_k127_1782656_1 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 339.0
TLS2_k127_1782656_2 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000000000000000000000000000000001312 211.0
TLS2_k127_1782656_3 Protein of unknown function (DUF1269) - - - 0.0000000000000000000001261 104.0
TLS2_k127_1782656_4 PFAM RNP-1 like RNA-binding protein - - - 0.00000000000001168 76.0
TLS2_k127_1792876_0 Catalyzes the dehydration of D-mannonate K01686 - 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 478.0
TLS2_k127_1792876_1 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000001609 221.0
TLS2_k127_1792876_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01856 - 5.5.1.1 0.0000000000000000000000000000000000000000000005663 181.0
TLS2_k127_1792876_3 Protein of unknown function (DUF1697) - - - 0.00000000000000000000000000000000000006317 146.0
TLS2_k127_1792876_4 PFAM Peptidase family M23 - - - 0.000001195 57.0
TLS2_k127_1828381_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0 1007.0
TLS2_k127_1828381_1 Helicase conserved C-terminal domain - - - 1.572e-215 679.0
TLS2_k127_1828381_2 TIGRFAM DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 364.0
TLS2_k127_1828381_3 Calcineurin-like phosphoesterase K01028,K07098 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009626 335.0
TLS2_k127_1828381_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 306.0
TLS2_k127_1828381_5 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 310.0
TLS2_k127_1828381_6 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K01153,K06042,K22491 - 3.1.21.3,5.4.99.60,5.4.99.61 0.0000000000000000000000000000000000000000000000000004135 191.0
TLS2_k127_1828381_7 - - - - 0.0000000000000000000000000000000000000000000001248 173.0
TLS2_k127_1861569_0 PFAM beta-lactamase domain protein K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 409.0
TLS2_k127_1861569_1 regulatory protein LysR K21703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006905 329.0
TLS2_k127_1861569_2 PFAM DinB family protein - - - 0.0000000000000000000000000000000000000000000000000006877 194.0
TLS2_k127_1861569_3 PFAM Rhodanese domain protein - - - 0.000000000000000000000000000000000004461 141.0
TLS2_k127_1876228_0 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 1.328e-287 897.0
TLS2_k127_1876228_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 417.0
TLS2_k127_1876228_2 Aldo/keto reductase family K00064 - 1.1.1.122 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 385.0
TLS2_k127_1876228_3 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 317.0
TLS2_k127_1876228_4 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 300.0
TLS2_k127_1876228_5 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0000000000000000000000000000000000000000000000000001413 186.0
TLS2_k127_1876228_6 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000003741 137.0
TLS2_k127_1876228_7 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.0000000000000000000000552 106.0
TLS2_k127_1876228_8 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.000000000000000001384 87.0
TLS2_k127_1876228_9 PFAM Transposase IS66 family K07484 - - 0.000001796 54.0
TLS2_k127_1879621_0 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 473.0
TLS2_k127_1879621_1 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003059 268.0
TLS2_k127_1879621_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009425 268.0
TLS2_k127_1879621_3 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009428 255.0
TLS2_k127_1882282_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 526.0
TLS2_k127_1882282_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 507.0
TLS2_k127_1882282_2 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006154 501.0
TLS2_k127_1882282_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 442.0
TLS2_k127_1882282_4 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 325.0
TLS2_k127_1882282_5 inositol 2-dehydrogenase activity - - - 0.000000000000000001076 99.0
TLS2_k127_1882282_6 Methane oxygenase PmoA - - - 0.00000000000000001913 95.0
TLS2_k127_1882282_7 Mannose-6-phosphate isomerase - - - 0.000003034 53.0
TLS2_k127_1890347_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 1.775e-225 718.0
TLS2_k127_1890347_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008844 425.0
TLS2_k127_1890347_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 408.0
TLS2_k127_1890347_3 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 360.0
TLS2_k127_1890347_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 302.0
TLS2_k127_1890347_5 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003922 273.0
TLS2_k127_1890347_6 oxidoreductase activity K00010 - 1.1.1.18,1.1.1.369 0.00000000000000000000000000000000000000000000002481 185.0
TLS2_k127_1890347_7 DinB family - - - 0.000000000000000000000000000000000000000000005619 168.0
TLS2_k127_1890347_8 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000005835 138.0
TLS2_k127_1899537_0 2-Nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 525.0
TLS2_k127_1899537_1 Belongs to the arginase family K01476 - 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 310.0
TLS2_k127_1899537_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000002256 256.0
TLS2_k127_1899537_3 - - - - 0.0000001822 61.0
TLS2_k127_1909016_0 PFAM VanW family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008134 470.0
TLS2_k127_1909016_1 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17242,K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 386.0
TLS2_k127_1909016_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 366.0
TLS2_k127_1926143_0 Tryptophan halogenase K14266 - 1.14.19.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009246 322.0
TLS2_k127_1926143_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000001182 249.0
TLS2_k127_1926143_2 Nitroreductase family - - - 0.00000000000000000000000000000000000000000001272 175.0
TLS2_k127_1926143_3 PFAM UBA THIF-type NAD FAD binding - - - 0.0000000000000000000000000000000003293 146.0
TLS2_k127_1926143_4 Peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000000006789 88.0
TLS2_k127_1953669_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 5.163e-227 719.0
TLS2_k127_1953669_1 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 1.713e-217 688.0
TLS2_k127_1953669_10 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001005 249.0
TLS2_k127_1953669_11 phosphorelay signal transduction system K07670 - - 0.00000000000000000000000000000000000000000000000000000000000002963 222.0
TLS2_k127_1953669_12 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000001245 216.0
TLS2_k127_1953669_13 Cytochrome c oxidase subunit III - - - 0.000000000000000000000000000000000000000002765 165.0
TLS2_k127_1953669_14 Superfamily I DNA and RNA helicases and helicase subunits - - - 0.000000000000000000000000000000000000000006926 173.0
TLS2_k127_1953669_15 Gluconate 2-dehydrogenase subunit 3 K06152 - 1.1.99.3 0.000000000000000000000000000000000000003137 159.0
TLS2_k127_1953669_16 cytochrome C peroxidase - - - 0.00000000000000000000000000000000001572 145.0
TLS2_k127_1953669_17 Cytochrome c - - - 0.0000000000000000000000000001601 119.0
TLS2_k127_1953669_18 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000007319 115.0
TLS2_k127_1953669_19 cytochrome C peroxidase - - - 0.00000000000000001095 92.0
TLS2_k127_1953669_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 5.544e-200 630.0
TLS2_k127_1953669_20 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000007273 68.0
TLS2_k127_1953669_21 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.0000000001271 67.0
TLS2_k127_1953669_22 - - - - 0.00002357 53.0
TLS2_k127_1953669_3 Oxidoreductase K06151 - 1.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 540.0
TLS2_k127_1953669_4 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009394 514.0
TLS2_k127_1953669_5 DNA polymerase K02337,K14162 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 505.0
TLS2_k127_1953669_6 PFAM binding-protein-dependent transport systems inner membrane component K02033,K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 379.0
TLS2_k127_1953669_7 PFAM binding-protein-dependent transport systems inner membrane component K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007177 334.0
TLS2_k127_1953669_8 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 312.0
TLS2_k127_1953669_9 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008205 304.0
TLS2_k127_1959602_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 343.0
TLS2_k127_1959602_1 transposition, DNA-mediated K02342,K07480 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009974 294.0
TLS2_k127_1959602_2 PFAM binding-protein-dependent transport systems inner membrane component K02025,K17245 - - 0.00000000000000000000000000000000000000000000000000000000000000003213 233.0
TLS2_k127_1959602_3 PFAM Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000004144 237.0
TLS2_k127_1959602_4 HTH-like domain K07497 - - 0.0000000000000007201 79.0
TLS2_k127_1959602_5 Magnesium chelatase, subunit ChlI K07391 - - 0.00000108 53.0
TLS2_k127_1959602_6 Protein of unknown function (DUF1679) - - - 0.00001172 58.0
TLS2_k127_1959602_7 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.000447 42.0
TLS2_k127_1979595_0 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 461.0
TLS2_k127_1979595_1 PFAM ABC-3 protein K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004582 427.0
TLS2_k127_1979595_2 PFAM ABC transporter related K11710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 380.0
TLS2_k127_1979595_3 ABC 3 transport family K11708 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 382.0
TLS2_k127_1979595_4 Belongs to the bacterial solute-binding protein 9 family K11707 - - 0.0000000000000000000000000000000000000000000000000000000000000002419 222.0
TLS2_k127_1979595_6 - - - - 0.000001945 55.0
TLS2_k127_2000069_0 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 569.0
TLS2_k127_2000069_1 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 447.0
TLS2_k127_2000069_2 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 409.0
TLS2_k127_2000069_3 sh3 domain protein K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 362.0
TLS2_k127_2000069_4 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005637 246.0
TLS2_k127_2000069_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000005064 76.0
TLS2_k127_2000069_6 MarR family - - - 0.0000001476 60.0
TLS2_k127_2000069_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0003875 53.0
TLS2_k127_2003289_0 DHH family K07462 - - 1.903e-271 857.0
TLS2_k127_2003289_1 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 431.0
TLS2_k127_2003289_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 415.0
TLS2_k127_2003289_3 Helix-turn-helix domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 332.0
TLS2_k127_2003289_4 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 318.0
TLS2_k127_2003289_5 PFAM Exonuclease, RNase T and DNA polymerase III K02342,K03722 - 2.7.7.7,3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 306.0
TLS2_k127_2003289_6 Cytidine monophosphokinase K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001477 277.0
TLS2_k127_2003289_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000009018 242.0
TLS2_k127_2005212_0 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 403.0
TLS2_k127_2005212_1 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000003472 244.0
TLS2_k127_2005212_2 kinase activity K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000009894 170.0
TLS2_k127_2005212_3 cytochrome c oxidase K02351,K07245 - - 0.00000000000000000000000000000000000000000009763 171.0
TLS2_k127_2009632_0 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008298 301.0
TLS2_k127_2009632_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002171 283.0
TLS2_k127_2009632_2 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000001661 254.0
TLS2_k127_2031165_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.172e-316 979.0
TLS2_k127_2031165_1 Polynucleotide adenylyltransferase region K00974 - 2.7.7.72 9.357e-310 977.0
TLS2_k127_2031165_10 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 577.0
TLS2_k127_2031165_11 FAD binding domain K05712,K16022,K20943,K20944 - 1.14.13.127,1.14.13.219,1.14.13.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 515.0
TLS2_k127_2031165_12 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006866 458.0
TLS2_k127_2031165_13 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 425.0
TLS2_k127_2031165_14 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004394 418.0
TLS2_k127_2031165_15 Belongs to the TrpC family K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 416.0
TLS2_k127_2031165_16 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 441.0
TLS2_k127_2031165_17 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 389.0
TLS2_k127_2031165_18 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 379.0
TLS2_k127_2031165_19 8-amino-7-oxononanoate synthase activity K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009077 375.0
TLS2_k127_2031165_2 ABC transporter, transmembrane region K06147,K18890 - - 3.337e-263 825.0
TLS2_k127_2031165_20 PFAM extracellular solute-binding protein family 1 K15770 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 363.0
TLS2_k127_2031165_21 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 318.0
TLS2_k127_2031165_22 PFAM metallophosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 308.0
TLS2_k127_2031165_23 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 289.0
TLS2_k127_2031165_24 Domain of unknown function (DUF4037) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003591 280.0
TLS2_k127_2031165_25 ethanolamine kinase activity K07251 - 2.7.1.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004293 279.0
TLS2_k127_2031165_26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000004567 269.0
TLS2_k127_2031165_27 Belongs to the LDH2 MDH2 oxidoreductase family K00073 - 1.1.1.350 0.0000000000000000000000000000000000000000000000000000000000000000000000000001943 268.0
TLS2_k127_2031165_28 PFAM Shikimate quinate 5-dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009519 264.0
TLS2_k127_2031165_29 SpoU rRNA Methylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000005375 235.0
TLS2_k127_2031165_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 3.865e-248 773.0
TLS2_k127_2031165_30 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000009818 232.0
TLS2_k127_2031165_31 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000002805 226.0
TLS2_k127_2031165_32 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000001059 213.0
TLS2_k127_2031165_33 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000001112 184.0
TLS2_k127_2031165_35 PFAM DSBA oxidoreductase - - - 0.0000000000000000000000000000000000000000001103 165.0
TLS2_k127_2031165_36 cell septum assembly K02487,K06596,K08372 - - 0.000000000000000000000000000000000000000001951 177.0
TLS2_k127_2031165_39 cell septum assembly K02487,K06596,K08372 - - 0.000000000000000000000000000000008074 142.0
TLS2_k127_2031165_4 PFAM ABC transporter transmembrane region K06147 - - 1.631e-228 722.0
TLS2_k127_2031165_41 - - - - 0.000000000000000000000000000004776 123.0
TLS2_k127_2031165_42 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000004109 134.0
TLS2_k127_2031165_44 self proteolysis K01447 - 3.5.1.28 0.000000000000000000001639 110.0
TLS2_k127_2031165_45 TfoX N-terminal domain K07343 - - 0.000000000000000000002493 99.0
TLS2_k127_2031165_47 cell adhesion involved in biofilm formation - - - 0.0000002955 63.0
TLS2_k127_2031165_5 Amidohydrolase family - - - 3.508e-228 713.0
TLS2_k127_2031165_6 positive regulation of transcription, DNA-templated K09684 - - 6.701e-220 696.0
TLS2_k127_2031165_7 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 1.884e-205 651.0
TLS2_k127_2031165_8 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 587.0
TLS2_k127_2031165_9 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 586.0
TLS2_k127_2032747_0 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 322.0
TLS2_k127_2032747_1 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007784 306.0
TLS2_k127_2032747_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 292.0
TLS2_k127_2032747_3 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002137 279.0
TLS2_k127_2032747_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004836 283.0
TLS2_k127_2032747_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000005277 229.0
TLS2_k127_2032747_6 PFAM Extracellular ligand-binding receptor K01999 - - 0.0006973 45.0
TLS2_k127_203822_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1028.0
TLS2_k127_203822_1 peptidase dimerisation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 422.0
TLS2_k127_203822_2 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 306.0
TLS2_k127_203822_3 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 299.0
TLS2_k127_203822_4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 291.0
TLS2_k127_203822_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001586 259.0
TLS2_k127_203822_6 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000001019 214.0
TLS2_k127_203822_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000001214 165.0
TLS2_k127_203822_8 rRNA binding K02926 - - 0.0000000000000000001299 102.0
TLS2_k127_203822_9 Domain of unknown function K20276 - - 0.000000000000000003776 99.0
TLS2_k127_2045799_0 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006323 446.0
TLS2_k127_2045799_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008516 302.0
TLS2_k127_2045799_2 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000000006556 156.0
TLS2_k127_2045799_3 CAAX protease self-immunity - - - 0.000000000000000000000000000000000006005 144.0
TLS2_k127_2045799_4 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.000000000000000000000009953 108.0
TLS2_k127_2045799_5 alpha beta K06889 - - 0.000158 44.0
TLS2_k127_2069950_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - - 0.0 1110.0
TLS2_k127_2069950_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 4.245e-229 719.0
TLS2_k127_2069950_10 Protein of unknown function (DUF1257) - - - 0.000000000000000000000000000000000000006939 149.0
TLS2_k127_2069950_2 4fe-4S ferredoxin, iron-sulfur binding domain protein K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 559.0
TLS2_k127_2069950_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 555.0
TLS2_k127_2069950_4 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 358.0
TLS2_k127_2069950_5 PFAM FAD linked oxidase domain protein K11472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 319.0
TLS2_k127_2069950_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000004523 233.0
TLS2_k127_2069950_7 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000006264 230.0
TLS2_k127_2069950_9 zinc ion binding K06204 - - 0.000000000000000000000000000000000000000000000201 171.0
TLS2_k127_2076603_0 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives K02343 - 2.7.7.7 1.252e-210 664.0
TLS2_k127_2076603_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 398.0
TLS2_k127_2076603_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K18983 - 5.5.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009696 332.0
TLS2_k127_2076603_3 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 330.0
TLS2_k127_2076603_4 mandelate racemase muconate lactonizing K01684,K01781,K08323 - 4.2.1.6,4.2.1.8,5.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 301.0
TLS2_k127_2076603_5 TadE-like protein - - - 0.00000008862 60.0
TLS2_k127_2085046_0 NB-ARC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 416.0
TLS2_k127_2085046_1 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 393.0
TLS2_k127_2085046_10 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000001325 130.0
TLS2_k127_2085046_11 PFAM magnesium chelatase ChlI subunit K07391 - - 0.00000000000000000000000000000764 121.0
TLS2_k127_2085046_12 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000002836 118.0
TLS2_k127_2085046_13 PFAM magnesium chelatase ChlI subunit K07391 - - 0.00000000000000000000002943 104.0
TLS2_k127_2085046_14 HTH-like domain K07497 - - 0.0000000000000000000008682 98.0
TLS2_k127_2085046_15 ABC transporter K02027 - - 0.000000000000000000003359 108.0
TLS2_k127_2085046_16 ATPase with chaperone activity K07391 - - 0.000007653 50.0
TLS2_k127_2085046_17 transporter K05819 - - 0.00002761 56.0
TLS2_k127_2085046_18 ester cyclase - - - 0.00003538 47.0
TLS2_k127_2085046_19 PFAM transposase, mutator type K07493 - - 0.0001199 44.0
TLS2_k127_2085046_2 Peptidase S9 prolyl oligopeptidase active site - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 368.0
TLS2_k127_2085046_20 SnoaL-like polyketide cyclase - - - 0.0003504 43.0
TLS2_k127_2085046_3 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 337.0
TLS2_k127_2085046_4 COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.00000000000000000000000000000000000000000000000000000000000000006091 232.0
TLS2_k127_2085046_5 PFAM Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000002343 232.0
TLS2_k127_2085046_6 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000001004 221.0
TLS2_k127_2085046_7 methyltransferase - - - 0.0000000000000000000000000000000001199 143.0
TLS2_k127_2085046_8 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17242,K17316 - - 0.000000000000000000000000000000003545 131.0
TLS2_k127_2085046_9 PFAM Transposase, Mutator - - - 0.00000000000000000000000000000002152 129.0
TLS2_k127_2087032_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07306,K08352 - 1.8.5.3,1.8.5.5 0.0 1175.0
TLS2_k127_2087032_1 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 2.33e-321 1007.0
TLS2_k127_2087032_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 3.037e-222 699.0
TLS2_k127_2087032_3 Bacterial transcriptional activator domain - - - 6.046e-214 705.0
TLS2_k127_2087032_4 Binding-protein-dependent transport systems inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 526.0
TLS2_k127_2087032_5 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008459 458.0
TLS2_k127_2087032_6 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 411.0
TLS2_k127_2087032_7 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 393.0
TLS2_k127_2087032_8 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 342.0
TLS2_k127_2092565_0 Domain of unknown function DUF87 K06915 - - 5.721e-256 800.0
TLS2_k127_2092565_1 Thermophilic metalloprotease (M29) K19689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 386.0
TLS2_k127_2092565_2 NAD(P)H quinone oxidoreductase, PIG3 family K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 335.0
TLS2_k127_2092565_3 AdoMet dependent proline di-methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000001198 269.0
TLS2_k127_2092565_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001796 255.0
TLS2_k127_2092565_5 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - 0.0000000000000000000000000000000000000000000000000000002922 196.0
TLS2_k127_2092565_6 CBS domain - - - 0.000000000000000000000000000000000000000000000000002549 186.0
TLS2_k127_2092565_7 - - - - 0.000000000000000000000000000003917 126.0
TLS2_k127_2092565_8 transposase or invertase - - - 0.00000000353 58.0
TLS2_k127_2092565_9 Peptidase_C39 like family - - - 0.000006324 55.0
TLS2_k127_2096455_0 Asparagine synthase K01953 - 6.3.5.4 2.9e-245 775.0
TLS2_k127_2096455_1 AMP-binding enzyme C-terminal domain - - - 1.5e-224 706.0
TLS2_k127_2096455_10 Glycosyl transferase, family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 297.0
TLS2_k127_2096455_11 PFAM O-antigen polymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005091 279.0
TLS2_k127_2096455_12 PFAM Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004601 260.0
TLS2_k127_2096455_13 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000001473 240.0
TLS2_k127_2096455_14 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000005584 207.0
TLS2_k127_2096455_15 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000003213 140.0
TLS2_k127_2096455_16 Phosphopantetheine attachment site - - - 0.000000000000000000000008057 103.0
TLS2_k127_2096455_17 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000009084 111.0
TLS2_k127_2096455_18 WD40-like Beta Propeller Repeat - - - 0.0000000000006866 83.0
TLS2_k127_2096455_19 Acyl carrier protein - - - 0.0000000000737 66.0
TLS2_k127_2096455_2 Belongs to the ATP-dependent AMP-binding enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 550.0
TLS2_k127_2096455_20 DltD protein - - - 0.00000000009278 73.0
TLS2_k127_2096455_21 metallopeptidase activity - - - 0.000000001171 72.0
TLS2_k127_2096455_22 Glycosyltransferase Family 4 - - - 0.00000006234 64.0
TLS2_k127_2096455_23 Acyltransferase family - - - 0.00000006547 64.0
TLS2_k127_2096455_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 509.0
TLS2_k127_2096455_4 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 455.0
TLS2_k127_2096455_5 Tryptophan halogenase K16033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 435.0
TLS2_k127_2096455_6 NAD+ synthase (glutamine-hydrolyzing) activity K01916 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 405.0
TLS2_k127_2096455_7 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 356.0
TLS2_k127_2096455_8 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 318.0
TLS2_k127_2096455_9 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009185 304.0
TLS2_k127_2101702_0 Thiamine pyrophosphate enzyme, central domain K03336 - 3.7.1.22 7.126e-295 915.0
TLS2_k127_2101702_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 5.977e-237 740.0
TLS2_k127_2101702_2 pfkB family carbohydrate kinase K03338 - 2.7.1.92 0.00000000000000000001401 91.0
TLS2_k127_2112709_0 PFAM peptidase M16 domain protein K06972 - - 0.0 1124.0
TLS2_k127_2112709_1 TIGRFAM tRNA-guanine transglycosylase, various specificities K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 479.0
TLS2_k127_2112709_10 Ribosomal RNA methyltransferase (FmrO) K18845 - 2.1.1.179 0.00000000000000000000000000000000000000000000000003415 190.0
TLS2_k127_2112709_11 methylglyoxal synthase K01734 - 4.2.3.3 0.00000000000000000000000000000000000000000000000004377 181.0
TLS2_k127_2112709_12 sh3 domain protein K01448,K04771,K08884 - 2.7.11.1,3.4.21.107,3.5.1.28 0.000000000000000000000000000000000000000000000001406 196.0
TLS2_k127_2112709_13 - - - - 0.000000000000000000000000000006668 122.0
TLS2_k127_2112709_14 methyltransferase activity - - - 0.000000000000000000000000001338 117.0
TLS2_k127_2112709_2 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 481.0
TLS2_k127_2112709_3 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 389.0
TLS2_k127_2112709_4 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 321.0
TLS2_k127_2112709_5 purine-nucleoside phosphorylase activity K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000001899 243.0
TLS2_k127_2112709_6 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000000000000006321 220.0
TLS2_k127_2112709_7 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000004152 211.0
TLS2_k127_2112709_8 Oxidoreductase family, NAD-binding Rossmann fold - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016491,GO:0019362,GO:0019637,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901360,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000003006 208.0
TLS2_k127_2112709_9 CHAT domain - - - 0.000000000000000000000000000000000000000000000000002166 203.0
TLS2_k127_2123978_0 transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 411.0
TLS2_k127_2123978_1 Phosphonate metabolism K06162 GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0044237,GO:0046434,GO:0071704,GO:1901575 3.6.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 345.0
TLS2_k127_2123978_2 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity K05780 - 2.7.8.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007257 290.0
TLS2_k127_2123978_3 peptidase activity, acting on L-amino acid peptides K01337,K20276 - 3.4.21.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000007111 287.0
TLS2_k127_2123978_4 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000005859 186.0
TLS2_k127_2123978_5 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000000000002129 184.0
TLS2_k127_2123978_6 phosphonate C-P lyase system protein PhnK K05781 - - 0.000000000000000000000000000000000000002031 147.0
TLS2_k127_2130001_0 intracellular signal transduction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009287 368.0
TLS2_k127_2130001_1 Cadherin repeats. - - - 0.0000000000000000000000000000000000000000000000000000000000000000009108 260.0
TLS2_k127_2130001_2 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.00000000000000000000000000000000005464 156.0
TLS2_k127_2130001_3 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000204 133.0
TLS2_k127_2130001_4 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000003621 69.0
TLS2_k127_2178909_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 2.258e-234 730.0
TLS2_k127_2178909_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008692 562.0
TLS2_k127_2178909_2 PFAM PfkB domain protein K00856 - 2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 455.0
TLS2_k127_2178909_3 acetyltransferase K00950,K03789,K03823 - 2.3.1.128,2.3.1.183,2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000004864 236.0
TLS2_k127_2179275_0 PFAM oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 488.0
TLS2_k127_2179275_1 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 473.0
TLS2_k127_2179275_2 PFAM ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000416 380.0
TLS2_k127_2179275_3 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 345.0
TLS2_k127_2179275_4 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006073 287.0
TLS2_k127_2179275_5 Family of unknown function (DUF1028) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001826 235.0
TLS2_k127_2225895_0 Common central domain of tyrosinase K00505 - 1.14.18.1 0.0000000000000000000000000000000000000000000000000000001091 213.0
TLS2_k127_2225895_1 - - - - 0.00000000000000000000000001185 116.0
TLS2_k127_2233214_0 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 526.0
TLS2_k127_2233214_1 TIGRFAM MazG family protein K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 334.0
TLS2_k127_2233214_2 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000701 261.0
TLS2_k127_2233214_3 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000005696 216.0
TLS2_k127_2233214_4 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000001864 104.0
TLS2_k127_2236169_0 pyruvate phosphate dikinase, PEP K01007 - 2.7.9.2 1.801e-282 897.0
TLS2_k127_2236169_1 cobalamin binding K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 301.0
TLS2_k127_2236169_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004186 274.0
TLS2_k127_2236169_3 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000005009 156.0
TLS2_k127_2236169_4 NUDIX domain - - - 0.000000000000000000000000001407 118.0
TLS2_k127_2237345_0 glutamate synthase, alpha subunit domain protein K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2354.0
TLS2_k127_2237345_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1133.0
TLS2_k127_2237345_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009406 288.0
TLS2_k127_2237345_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000507 302.0
TLS2_k127_2237345_13 S23 ribosomal protein - - - 0.00000000000000000000000000000000000000000000003957 173.0
TLS2_k127_2237345_14 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000005243 171.0
TLS2_k127_2237345_15 Putative heavy-metal-binding - - - 0.0000000000000000000000000000002557 130.0
TLS2_k127_2237345_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.461e-273 849.0
TLS2_k127_2237345_3 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649,K02594 - 2.3.3.13,2.3.3.14 1.64e-233 729.0
TLS2_k127_2237345_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.115e-201 638.0
TLS2_k127_2237345_5 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 7.638e-200 628.0
TLS2_k127_2237345_6 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 560.0
TLS2_k127_2237345_7 dioxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 413.0
TLS2_k127_2237345_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 421.0
TLS2_k127_2237345_9 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 401.0
TLS2_k127_2247822_0 Belongs to the glycosyl hydrolase 2 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007792 569.0
TLS2_k127_2247822_1 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 351.0
TLS2_k127_2247822_2 glycerophosphodiester transmembrane transport K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 341.0
TLS2_k127_2247822_3 carbohydrate transport K02027 - - 0.0000000000000000000000000000000001857 136.0
TLS2_k127_2261027_0 Glycosyl hydrolases family 32 N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 358.0
TLS2_k127_2261027_1 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 314.0
TLS2_k127_2297137_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 2.555e-237 752.0
TLS2_k127_2297137_1 FtsX-like permease family K02004 - - 5.026e-196 635.0
TLS2_k127_2297137_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 535.0
TLS2_k127_2297137_3 mandelate racemase muconate lactonizing K01684 - 4.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009581 467.0
TLS2_k127_2297137_4 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 286.0
TLS2_k127_2297137_5 KR domain K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002917 277.0
TLS2_k127_2297137_6 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000644 262.0
TLS2_k127_2297137_7 Major Facilitator Superfamily - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000001478 201.0
TLS2_k127_2299779_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 371.0
TLS2_k127_2299779_1 glycine betaine transport K02002 - - 0.00000000000000000000000000000000000000000000000000000000003901 218.0
TLS2_k127_2299779_2 ethanolamine kinase activity K07251,K18844 - 2.7.1.89 0.000001085 60.0
TLS2_k127_2299959_0 Mandelate racemase muconate lactonizing enzyme K01683 - 4.2.1.5 0.0000000000000000000000000000000000000000000000000245 194.0
TLS2_k127_2299959_1 - - - - 0.000000000000000000000001132 114.0
TLS2_k127_2299959_2 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.00000005433 63.0
TLS2_k127_2300541_0 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032,K10823,K10824 - 3.6.3.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006723 411.0
TLS2_k127_2300541_1 ABC-type dipeptide oligopeptide nickel transport system ATPase component K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 388.0
TLS2_k127_2300541_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 375.0
TLS2_k127_2300541_3 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 304.0
TLS2_k127_2300541_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 303.0
TLS2_k127_2300541_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000003119 150.0
TLS2_k127_2307032_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 4.786e-199 634.0
TLS2_k127_2307032_1 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008007 342.0
TLS2_k127_2307032_2 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002011 256.0
TLS2_k127_2307032_3 COG0224 F0F1-type ATP synthase gamma subunit K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001505 257.0
TLS2_k127_2307032_4 COG0471 Di- and tricarboxylate transporters K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000005731 241.0
TLS2_k127_2307032_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000000000005323 145.0
TLS2_k127_2307032_6 ATP synthase F(0) sector subunit b K02109 - - 0.000000000000000000000000000000000004099 148.0
TLS2_k127_2309585_0 CO dehydrogenase flavoprotein C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 313.0
TLS2_k127_2309585_1 A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 303.0
TLS2_k127_2309585_2 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000001597 264.0
TLS2_k127_2309585_3 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000003342 181.0
TLS2_k127_2309585_4 - - - - 0.00000000000000000000000000000000000000000008332 160.0
TLS2_k127_2309585_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000002587 127.0
TLS2_k127_2309585_6 - - - - 0.0004181 48.0
TLS2_k127_2322001_0 N-terminal 7TM region of histidine kinase - - - 2.809e-254 801.0
TLS2_k127_2322001_1 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 440.0
TLS2_k127_2322001_3 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000000000000000000000000000001815 205.0
TLS2_k127_2322001_4 CAAX protease self-immunity - - - 0.000000000000000000000000000005604 130.0
TLS2_k127_2322001_5 PFAM helix-turn-helix domain protein - - - 0.0000000000000004829 88.0
TLS2_k127_2330844_0 PFAM Glycosyl transferase family 2 K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 486.0
TLS2_k127_2330844_1 Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 324.0
TLS2_k127_2330844_2 PFAM Disulphide bond formation protein DsbB K03611 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002248 286.0
TLS2_k127_2330844_3 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000003844 237.0
TLS2_k127_2330844_4 PFAM peptidylprolyl isomerase FKBP-type K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000005199 219.0
TLS2_k127_2401975_0 Carbamoyltransferase C-terminus K00612 - - 1.267e-228 722.0
TLS2_k127_2401975_1 nitrite reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000586 488.0
TLS2_k127_2401975_10 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000005942 132.0
TLS2_k127_2401975_11 - - - - 0.00000000000000000000000006052 109.0
TLS2_k127_2401975_12 Domain of unknown function (DUF4157) K02689,K02690 - - 0.0000000000000000316 92.0
TLS2_k127_2401975_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00176,K00338 - 1.2.7.3,1.6.5.3 0.000000000000057 74.0
TLS2_k127_2401975_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 347.0
TLS2_k127_2401975_3 PFAM Luciferase-like K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 324.0
TLS2_k127_2401975_4 quinone binding K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 316.0
TLS2_k127_2401975_5 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000003468 250.0
TLS2_k127_2401975_6 - - - - 0.0000000000000000000000000000000000001336 147.0
TLS2_k127_2401975_7 - - - - 0.00000000000000000000000000000000001273 140.0
TLS2_k127_2401975_8 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000000000002259 123.0
TLS2_k127_2401975_9 PFAM Cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000003917 125.0
TLS2_k127_2412952_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652,K03852 - 2.2.1.6,2.3.3.15 1.633e-259 809.0
TLS2_k127_2412952_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 373.0
TLS2_k127_2412952_2 Glycosyl hydrolase family 32 K01193,K03332 - 3.2.1.26,3.2.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 329.0
TLS2_k127_2412952_3 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000003161 137.0
TLS2_k127_2412952_4 sequence-specific DNA binding - - - 0.000000000000000000000000000001107 127.0
TLS2_k127_2412952_5 Transcriptional regulator padr family - - - 0.00000000000000000135 91.0
TLS2_k127_2412952_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000002812 96.0
TLS2_k127_2412952_7 peptidase activity K01286 - 3.4.16.4 0.000004301 56.0
TLS2_k127_2419611_0 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 331.0
TLS2_k127_2419611_1 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001382 281.0
TLS2_k127_2419611_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000008177 203.0
TLS2_k127_2419611_3 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000006198 142.0
TLS2_k127_2419611_4 Carbon-nitrogen hydrolase - - - 0.000000000000000000000001919 118.0
TLS2_k127_2419611_5 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000003605 83.0
TLS2_k127_2419611_6 mandelate racemase muconate lactonizing - - - 0.00000000000001348 74.0
TLS2_k127_242086_0 SPTR Q471D1 TPR repeat Bacterial transcriptional activator domain Tetratricopeptide TPR_4 - - - 0.000000000000000000000000000000000000000000000000000000003504 224.0
TLS2_k127_242086_1 DNA-binding transcriptional activator of the SARP family - - - 0.00002482 57.0
TLS2_k127_2428358_0 ABC transporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 560.0
TLS2_k127_2428358_1 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 545.0
TLS2_k127_2428358_10 Sulfatase - - - 0.0000000000000000000000000000000000000000000000007125 191.0
TLS2_k127_2428358_11 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000002515 170.0
TLS2_k127_2428358_12 HAD-hyrolase-like K01560 - 3.8.1.2 0.00000000000000000000000000000000000000006044 161.0
TLS2_k127_2428358_13 PFAM Helix-turn-helix, type 11 domain protein - - - 0.0000000000000000000000000000001722 126.0
TLS2_k127_2428358_14 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000002011 75.0
TLS2_k127_2428358_2 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 513.0
TLS2_k127_2428358_3 TIGRFAM Ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 496.0
TLS2_k127_2428358_4 Belongs to the RimK family K05827 - 6.3.2.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 348.0
TLS2_k127_2428358_5 protein catabolic process K03420,K13525,K17681 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 304.0
TLS2_k127_2428358_6 Phosphorylase superfamily K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009334 284.0
TLS2_k127_2428358_7 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000002624 238.0
TLS2_k127_2428358_8 nitric oxide dioxygenase activity K13735 - - 0.00000000000000000000000000000000000000000000000000000000000000003335 228.0
TLS2_k127_2428358_9 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000005406 206.0
TLS2_k127_2492857_0 ethanolamine kinase activity K07251 - 2.7.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008929 277.0
TLS2_k127_2492857_1 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003122 270.0
TLS2_k127_2492857_10 Glycosyltransferase like family 2 - - - 0.000000000001688 74.0
TLS2_k127_2492857_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001127 257.0
TLS2_k127_2492857_3 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002794 248.0
TLS2_k127_2492857_4 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000009984 233.0
TLS2_k127_2492857_5 oxidation-reduction process - - - 0.00000000000000000000000000000000000000002079 156.0
TLS2_k127_2492857_6 COG0286 Type I restriction-modification system methyltransferase subunit K03427 - 2.1.1.72 0.000000000000000000000000000000000000001538 149.0
TLS2_k127_2492857_7 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.00000000000000000000000000000000000003889 149.0
TLS2_k127_2492857_8 DNA modification - - - 0.0000000000000000000000000000009113 122.0
TLS2_k127_2492857_9 Recombinase K06400 GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.000000000001537 75.0
TLS2_k127_2501290_0 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000001712 171.0
TLS2_k127_2501290_1 - - - - 0.000000000000000000000000000000000325 137.0
TLS2_k127_2501290_2 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000003174 131.0
TLS2_k127_2501290_3 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000005942 130.0
TLS2_k127_2501290_4 PFAM DsrE DsrF-like family - - - 0.00000000000000000000000000003453 121.0
TLS2_k127_2501866_0 PFAM sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 542.0
TLS2_k127_2501866_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007678 402.0
TLS2_k127_2501866_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 396.0
TLS2_k127_2501866_3 Nucleotidyl transferase K16881 - 2.7.7.13,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 303.0
TLS2_k127_2501866_4 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000006038 187.0
TLS2_k127_2501866_5 domain protein K12516 - - 0.000000000000000000000000000000006413 139.0
TLS2_k127_2501866_6 protein secretion - - - 0.00000000000000000009099 104.0
TLS2_k127_2501866_7 HemY domain protein - - - 0.0000000000000000001592 104.0
TLS2_k127_2501866_8 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00000000003603 70.0
TLS2_k127_250940_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000006464 237.0
TLS2_k127_250940_1 Belongs to the globin family K05916 - 1.14.12.17 0.0000000000000000000000000000002544 132.0
TLS2_k127_250940_3 PFAM CHAD domain containing protein - - - 0.0000000002075 70.0
TLS2_k127_2523948_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 7.405e-271 847.0
TLS2_k127_2523948_1 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 588.0
TLS2_k127_2523948_2 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001546 273.0
TLS2_k127_2523948_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000002356 154.0
TLS2_k127_2523948_4 Protein of unknown function (DUF448) K07742 - - 0.0000000000000000000000002353 109.0
TLS2_k127_2577908_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 4.345e-286 893.0
TLS2_k127_2577908_1 PFAM Alcohol dehydrogenase - - - 5.631e-206 646.0
TLS2_k127_2577908_10 PFAM Bacterial regulatory proteins, luxR family K03556 - - 0.0000000000002693 85.0
TLS2_k127_2577908_2 PFAM Mandelate racemase muconate lactonizing enzyme K01683,K01684,K08323 GO:0000287,GO:0003674,GO:0005488,GO:0043167,GO:0043169,GO:0046872 4.2.1.5,4.2.1.6,4.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 564.0
TLS2_k127_2577908_3 NB-ARC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 582.0
TLS2_k127_2577908_4 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 395.0
TLS2_k127_2577908_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007643 277.0
TLS2_k127_2577908_6 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000001245 216.0
TLS2_k127_2577908_7 - - - - 0.00000000000000000000000000000000000000000000002939 179.0
TLS2_k127_2577908_8 Ferric uptake regulator family K09825 - - 0.00000000000000000000000000000000000000000000003244 174.0
TLS2_k127_2577908_9 - - - - 0.00000000000000000000000000000000000000000000003412 176.0
TLS2_k127_2607334_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 599.0
TLS2_k127_2607334_1 Immune inhibitor A peptidase M6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 563.0
TLS2_k127_2607334_10 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 397.0
TLS2_k127_2607334_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 394.0
TLS2_k127_2607334_12 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000001809 230.0
TLS2_k127_2607334_13 phosphoprotein phosphatase activity K01090 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000003836 204.0
TLS2_k127_2607334_14 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000000004873 204.0
TLS2_k127_2607334_16 dehydrogenases and related proteins - - - 0.000000000000000000000000000000000000452 154.0
TLS2_k127_2607334_17 Membrane - - - 0.000000000000000000000000000000000003511 145.0
TLS2_k127_2607334_18 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000006715 135.0
TLS2_k127_2607334_2 bacterial-type flagellum-dependent cell motility K02396,K02397 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 557.0
TLS2_k127_2607334_3 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 497.0
TLS2_k127_2607334_4 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 478.0
TLS2_k127_2607334_5 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 460.0
TLS2_k127_2607334_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 452.0
TLS2_k127_2607334_7 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 424.0
TLS2_k127_2607334_8 ABC-type dipeptide transport system periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 439.0
TLS2_k127_2607334_9 Beta-lactamase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 420.0
TLS2_k127_2636798_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 2.709e-251 785.0
TLS2_k127_2636798_1 ATPase AAA-2 domain protein K03696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 482.0
TLS2_k127_2636798_10 PFAM peptidase M29, aminopeptidase II K19689 - - 0.00000000000000000000000000000000000000000000000000009094 189.0
TLS2_k127_2636798_11 ATPase, P-type transporting, HAD superfamily, subfamily IC K16905 - - 0.000000000000000000000000000000000000000000000000000236 194.0
TLS2_k127_2636798_12 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000002065 185.0
TLS2_k127_2636798_13 transmembrane transport K16906 - - 0.0000000000000000000000000000000000000000000001355 180.0
TLS2_k127_2636798_14 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000003155 160.0
TLS2_k127_2636798_15 MarR family - - - 0.0000000000000000000000000000000000002896 147.0
TLS2_k127_2636798_16 Acetyltransferase - - - 0.0000000000000001021 91.0
TLS2_k127_2636798_17 Putative lumazine-binding - - - 0.00000386 51.0
TLS2_k127_2636798_2 COG1131 ABC-type multidrug transport system ATPase component K16907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 384.0
TLS2_k127_2636798_3 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002673 364.0
TLS2_k127_2636798_4 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003664 342.0
TLS2_k127_2636798_5 nitrite transmembrane transporter activity K08191,K08369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 330.0
TLS2_k127_2636798_6 COGs COG0395 ABC-type sugar transport system permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 309.0
TLS2_k127_2636798_7 PFAM sodium calcium exchanger membrane region K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009113 254.0
TLS2_k127_2636798_8 COG1335 Amidases related to nicotinamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000568 228.0
TLS2_k127_2636798_9 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000001275 201.0
TLS2_k127_2704573_0 Monogalactosyldiacylglycerol synthase K03429 - 2.4.1.315 0.0000000000000000000000001511 119.0
TLS2_k127_2704573_1 - - - - 0.0000000000003546 75.0
TLS2_k127_2704573_2 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.00000000002331 74.0
TLS2_k127_2729580_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1233.0
TLS2_k127_2729580_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1022.0
TLS2_k127_2729580_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 6.929e-214 689.0
TLS2_k127_2729580_3 CO dehydrogenase flavoprotein C-terminal domain K11178 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000002135 275.0
TLS2_k127_2729580_4 PFAM 2Fe-2S -binding K03518,K07302,K13483 - 1.2.5.3,1.3.99.16 0.00000000000000000000000000000000000000000000000000000004079 200.0
TLS2_k127_2729580_5 Protein of unknown function (DUF4007) - - - 0.000000000000000001782 88.0
TLS2_k127_2746503_0 PFAM DEAD DEAH box helicase domain protein K03654 - 3.6.4.12 0.0 1218.0
TLS2_k127_2746503_1 NADH Ubiquinone plastoquinone (complex I) K05565,K14086 - - 2.482e-248 791.0
TLS2_k127_2746503_10 ROK family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 460.0
TLS2_k127_2746503_11 PFAM aminotransferase, class I and II K14155 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 464.0
TLS2_k127_2746503_12 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 359.0
TLS2_k127_2746503_13 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 346.0
TLS2_k127_2746503_15 Phage shock protein A K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007284 280.0
TLS2_k127_2746503_16 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000005575 227.0
TLS2_k127_2746503_17 pyridoxamine 5-phosphate - - - 0.00000000000000000000000000000000000000000000000000000000000001075 220.0
TLS2_k127_2746503_18 Inner membrane component domain - - - 0.000000000000000000000000000000000000000000000000007846 183.0
TLS2_k127_2746503_19 PFAM Na H antiporter MnhB subunit-related protein K05566 - - 0.0000000000000000000000000000000000008232 143.0
TLS2_k127_2746503_2 PFAM von Willebrand factor type A K07114 - - 5.396e-212 675.0
TLS2_k127_2746503_20 NADH-ubiquinone oxidoreductase chain 4l K05567 - - 0.000000000000000000000000000151 126.0
TLS2_k127_2746503_21 Cation antiporter K05569 - - 0.0000000000000000000000006948 110.0
TLS2_k127_2746503_22 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.000000000000000000000003076 106.0
TLS2_k127_2746503_23 monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.00000000000000000000002184 104.0
TLS2_k127_2746503_3 iron ion homeostasis - - - 1.243e-208 654.0
TLS2_k127_2746503_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 1.369e-199 628.0
TLS2_k127_2746503_5 Major Facilitator Superfamily K18833 - - 3.081e-195 618.0
TLS2_k127_2746503_6 TIGRFAM galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008233 537.0
TLS2_k127_2746503_7 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 562.0
TLS2_k127_2746503_8 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 488.0
TLS2_k127_2746503_9 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 475.0
TLS2_k127_2747431_0 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 419.0
TLS2_k127_2747431_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 345.0
TLS2_k127_2747431_2 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000007116 240.0
TLS2_k127_2760277_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009825 583.0
TLS2_k127_2760277_1 AIR synthase related protein domain protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009436 412.0
TLS2_k127_2760277_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 318.0
TLS2_k127_2760277_3 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001381 278.0
TLS2_k127_2760277_4 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000002899 227.0
TLS2_k127_2760277_5 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000001708 159.0
TLS2_k127_2760277_6 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000004573 130.0
TLS2_k127_2764893_0 FAD binding domain - - - 9.475e-194 619.0
TLS2_k127_2764893_1 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 331.0
TLS2_k127_2764893_2 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001499 255.0
TLS2_k127_2764893_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006557 265.0
TLS2_k127_2764893_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001367 235.0
TLS2_k127_2764893_5 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000719 238.0
TLS2_k127_2764893_6 - - - - 0.000000000000000000000000000000000001161 143.0
TLS2_k127_2764893_7 carboxylic ester hydrolase activity K15357 - 3.5.1.106 0.000000000002034 72.0
TLS2_k127_2764893_8 PKD domain - - - 0.000002218 51.0
TLS2_k127_2764893_9 N-terminal 7TM region of histidine kinase - - - 0.00001605 58.0
TLS2_k127_2804635_0 FAD dependent oxidoreductase central domain - - - 5.329e-309 967.0
TLS2_k127_2804635_1 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 4.253e-250 783.0
TLS2_k127_2804635_10 Protein of unknown function (DUF2283) - - - 0.0000000000000002821 80.0
TLS2_k127_2804635_2 trimethylamine methyltransferase K14083 - 2.1.1.250 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 580.0
TLS2_k127_2804635_3 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 544.0
TLS2_k127_2804635_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 537.0
TLS2_k127_2804635_5 PFAM Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 464.0
TLS2_k127_2804635_6 COG1410 Methionine synthase I cobalamin-binding domain K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 355.0
TLS2_k127_2804635_7 methylenetetrahydrofolate reductase (NAD(P)H) activity K00297,K00547 - 1.5.1.20,2.1.1.10 0.00000000000000000000000000000000000000000000000000002349 192.0
TLS2_k127_2804635_8 FCD - - - 0.00000000000000000000000000006414 126.0
TLS2_k127_2804635_9 - - - - 0.000000000000000000000006304 105.0
TLS2_k127_2805822_0 TIGRFAM cysteine desulfurase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 610.0
TLS2_k127_2805822_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 529.0
TLS2_k127_2805822_2 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008877 532.0
TLS2_k127_2805822_3 PFAM alanine dehydrogenase PNT domain protein K00259 - 1.4.1.1 0.000000000000000000001481 94.0
TLS2_k127_2805822_4 - - - - 0.0000000000002207 79.0
TLS2_k127_2805822_5 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000009591 56.0
TLS2_k127_2807802_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 550.0
TLS2_k127_2807802_1 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 529.0
TLS2_k127_2807802_2 PFAM UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 347.0
TLS2_k127_2807802_3 HsdM N-terminal domain K03427 - 2.1.1.72 0.0000000000000009228 79.0
TLS2_k127_2810606_0 Glycyl-tRNA synthetase alpha subunit K14164 - 6.1.1.14 0.0 1409.0
TLS2_k127_2830818_0 Protein of unknown function (DUF2961) - - - 9.295e-198 620.0
TLS2_k127_2830818_1 Trehalose utilisation K09992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 346.0
TLS2_k127_2830818_10 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000002758 216.0
TLS2_k127_2830818_11 anaphase-promoting complex-dependent catabolic process - - - 0.0000000000000000000000000000000000000000008253 167.0
TLS2_k127_2830818_12 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000006478 119.0
TLS2_k127_2830818_13 Mnh complex is a Na( ) H( ) antiporter involved in Na( ) excretion K05571 - - 0.000000007191 64.0
TLS2_k127_2830818_14 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05563 - - 0.0000004058 55.0
TLS2_k127_2830818_15 antiporter K05569 - - 0.00000319 57.0
TLS2_k127_2830818_2 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369,K13890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 335.0
TLS2_k127_2830818_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009952 276.0
TLS2_k127_2830818_5 PFAM alanine racemase domain protein K20757 - 4.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002168 276.0
TLS2_k127_2830818_6 hydroxypyruvate isomerase activity K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000001441 268.0
TLS2_k127_2830818_7 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.00000000000000000000000000000000000000000000000000000000000000000001539 244.0
TLS2_k127_2830818_8 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000006926 228.0
TLS2_k127_2830818_9 3-beta hydroxysteroid dehydrogenase/isomerase family K18981 - 1.1.1.203 0.00000000000000000000000000000000000000000000000000000001446 206.0
TLS2_k127_2847848_0 mandelate racemase muconate lactonizing K08323 GO:0000287,GO:0003674,GO:0005488,GO:0043167,GO:0043169,GO:0046872 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 535.0
TLS2_k127_2847848_1 D-mannonate dehydratase (UxuA) K01686 - 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 370.0
TLS2_k127_2847848_2 Cytochrome c K00412 - - 0.0000000000000000000000000000000000000000000000000000000000002786 220.0
TLS2_k127_2847848_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.000000000000000000000000000000000000000000000194 190.0
TLS2_k127_2847848_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000163 139.0
TLS2_k127_2847848_5 Extracellular solute-binding protein - - - 0.000000000003598 76.0
TLS2_k127_2880008_0 response regulator, receiver K09763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 327.0
TLS2_k127_2880008_1 enoyl-[acyl-carrier-protein] reductase (NADH) activity K10780 - 1.3.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001332 274.0
TLS2_k127_2880008_2 Divergent PAP2 family K09775 - - 0.000000000000000000000000000000000000000000004464 168.0
TLS2_k127_2880008_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000002283 95.0
TLS2_k127_2880008_4 Polysaccharide deacetylase - - - 0.00001929 46.0
TLS2_k127_2881442_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.0 1005.0
TLS2_k127_2881442_1 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008683 524.0
TLS2_k127_2881442_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 388.0
TLS2_k127_2881442_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00338,K03615 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 378.0
TLS2_k127_2881442_4 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 344.0
TLS2_k127_2881442_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000001696 219.0
TLS2_k127_2898102_0 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 489.0
TLS2_k127_2898102_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000003093 126.0
TLS2_k127_2898102_2 heme oxygenase (decyclizing) activity - - - 0.000000000000000000000008044 109.0
TLS2_k127_2898102_3 AAA domain - - - 0.00002683 55.0
TLS2_k127_2898620_0 ABC-type multidrug transport system ATPase and permease K06147 - - 5.983e-267 833.0
TLS2_k127_2898620_1 Dienelactone hydrolase family - - - 8.072e-255 801.0
TLS2_k127_2898620_10 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 346.0
TLS2_k127_2898620_11 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 312.0
TLS2_k127_2898620_12 Family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 310.0
TLS2_k127_2898620_13 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 303.0
TLS2_k127_2898620_14 Serine threonine protein K01090 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 289.0
TLS2_k127_2898620_15 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001417 282.0
TLS2_k127_2898620_16 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001465 254.0
TLS2_k127_2898620_17 regulation of response to stimulus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002852 261.0
TLS2_k127_2898620_18 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000002095 224.0
TLS2_k127_2898620_19 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000005809 210.0
TLS2_k127_2898620_2 (ABC) transporter K06147 - - 1.526e-239 754.0
TLS2_k127_2898620_20 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000004194 190.0
TLS2_k127_2898620_21 methyltransferase - - - 0.0000000000000000000000000000000000000000000007833 176.0
TLS2_k127_2898620_22 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000004772 172.0
TLS2_k127_2898620_23 oxidoreductase - - - 0.000000000000000000000000000000000000000001515 169.0
TLS2_k127_2898620_24 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000517 153.0
TLS2_k127_2898620_25 - - - - 0.000000000000000000000000000000000001214 148.0
TLS2_k127_2898620_26 small multidrug export protein - - - 0.00000000000000000000000000000001836 134.0
TLS2_k127_2898620_27 acetyltransferase - - - 0.000000000000000000000000002431 123.0
TLS2_k127_2898620_28 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000001735 122.0
TLS2_k127_2898620_29 META domain - - - 0.000000000000000000000009736 117.0
TLS2_k127_2898620_3 PFAM Uncharacterised BCR, COG1649 - - - 8.12e-218 684.0
TLS2_k127_2898620_30 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000003748 101.0
TLS2_k127_2898620_31 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000004637 106.0
TLS2_k127_2898620_32 META domain - - - 0.000000000000000000006078 108.0
TLS2_k127_2898620_33 - - - - 0.0000000000000000002464 101.0
TLS2_k127_2898620_34 Protein of unknown function (DUF1059) - - - 0.000000000000000006769 85.0
TLS2_k127_2898620_35 Phosphotransferase - - - 0.00000000000000006498 91.0
TLS2_k127_2898620_36 Oxidoreductase - - - 0.000000000000003837 87.0
TLS2_k127_2898620_37 Peptidase M24 K01271,K01274 - 3.4.13.9 0.000000000001969 79.0
TLS2_k127_2898620_38 protein conserved in bacteria K09992 - - 0.000000000004783 75.0
TLS2_k127_2898620_39 cell wall surface anchor family protein - - - 0.0000002954 62.0
TLS2_k127_2898620_4 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 559.0
TLS2_k127_2898620_40 PHAX RNA-binding domain K14291 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0006139,GO:0006351,GO:0006366,GO:0006403,GO:0006405,GO:0006408,GO:0006725,GO:0006807,GO:0006810,GO:0006913,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009301,GO:0009987,GO:0010467,GO:0015630,GO:0015643,GO:0015931,GO:0016070,GO:0016073,GO:0018130,GO:0019438,GO:0031974,GO:0031981,GO:0032774,GO:0033036,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0036477,GO:0042795,GO:0043025,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044297,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046907,GO:0050657,GO:0050658,GO:0051030,GO:0051168,GO:0051169,GO:0051179,GO:0051234,GO:0051236,GO:0051641,GO:0051649,GO:0070013,GO:0071702,GO:0071704,GO:0071705,GO:0090304,GO:0097064,GO:0097159,GO:0097458,GO:0097659,GO:0098781,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000001296 59.0
TLS2_k127_2898620_5 UDP-glucoronosyl and UDP-glucosyl transferase K05841 - 2.4.1.173 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 457.0
TLS2_k127_2898620_6 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000581 463.0
TLS2_k127_2898620_7 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 417.0
TLS2_k127_2898620_8 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004745 394.0
TLS2_k127_2898620_9 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 323.0
TLS2_k127_2900392_0 -O-antigen - - - 0.0 1224.0
TLS2_k127_2900392_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.864e-306 960.0
TLS2_k127_2900392_11 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.00000000000000000013 94.0
TLS2_k127_2900392_2 PFAM glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 506.0
TLS2_k127_2900392_3 PFAM glycosyl transferase group 1 K12995,K13668 - 2.4.1.346,2.4.1.348 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 473.0
TLS2_k127_2900392_4 Oxidoreductase family, C-terminal alpha beta domain K13020,K16043 - 1.1.1.335,1.1.1.370 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 341.0
TLS2_k127_2900392_5 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000003956 204.0
TLS2_k127_2900392_6 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000001184 197.0
TLS2_k127_2900392_7 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000006976 188.0
TLS2_k127_2900392_8 sh3 domain protein - - - 0.00000000000000000000000000000000003186 141.0
TLS2_k127_2900392_9 Cytochrome c K02275,K17223 - 1.9.3.1 0.00000000000000000000000000001543 125.0
TLS2_k127_2909516_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.238e-282 876.0
TLS2_k127_2909516_1 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 353.0
TLS2_k127_2909516_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001775 270.0
TLS2_k127_2909516_3 Two component transcriptional regulator, winged helix family K07670,K11329 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003507 260.0
TLS2_k127_2909516_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000005998 230.0
TLS2_k127_2909516_5 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000000006095 229.0
TLS2_k127_2909516_6 Pyridoxamine 5'-phosphate oxidase - - - 0.000001894 53.0
TLS2_k127_2914849_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 560.0
TLS2_k127_2914849_1 PFAM type II secretion system protein E K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 504.0
TLS2_k127_2914849_2 aminopeptidase activity K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009446 375.0
TLS2_k127_2914849_3 bile acid:sodium symporter activity K00041,K03453 - 1.1.1.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 328.0
TLS2_k127_2914849_4 glycerophosphodiester transmembrane transport K17243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001267 257.0
TLS2_k127_2914849_5 DNA mismatch repair protein MutT - - - 0.0000000000000000000000000000000000000000000000266 177.0
TLS2_k127_2914849_6 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000005805 94.0
TLS2_k127_2914849_8 acetyltransferase K15866,K19802 - 5.1.1.20,5.3.3.18 0.0000005991 61.0
TLS2_k127_292875_0 Polysaccharide biosynthesis protein - - - 0.0 1855.0
TLS2_k127_292875_1 L-aspartate oxidase K00278 - 1.4.3.16 2.512e-237 745.0
TLS2_k127_292875_10 TIGRFAM LAO AO transport system ATPase K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 363.0
TLS2_k127_292875_11 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 388.0
TLS2_k127_292875_12 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 339.0
TLS2_k127_292875_13 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 336.0
TLS2_k127_292875_14 TIGRFAM hydrolase, TatD family K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 330.0
TLS2_k127_292875_15 TIGRFAM conserved repeat domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 363.0
TLS2_k127_292875_16 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 322.0
TLS2_k127_292875_17 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 317.0
TLS2_k127_292875_18 PFAM Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001292 286.0
TLS2_k127_292875_19 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005001 262.0
TLS2_k127_292875_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840 - 5.4.2.8 1.02e-236 740.0
TLS2_k127_292875_20 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001216 263.0
TLS2_k127_292875_21 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003602 237.0
TLS2_k127_292875_22 response regulator, receiver K02479 - - 0.000000000000000000000000000000000000000000000000000000000000000003204 236.0
TLS2_k127_292875_23 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000000000000000000000000000000000002918 246.0
TLS2_k127_292875_24 PFAM cobalamin B12-binding domain protein K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000852 210.0
TLS2_k127_292875_25 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000000000000004002 199.0
TLS2_k127_292875_26 TIGRFAM competence protein ComEA helix-hairpin-helix repeat protein K02237 - - 0.000000000000000000000000000000000000000000000000001523 190.0
TLS2_k127_292875_28 Cache domain - - - 0.00000000000000000000000000000000000000000000008354 192.0
TLS2_k127_292875_29 Manganese containing catalase - - - 0.00000000000000000000000000000000002225 139.0
TLS2_k127_292875_3 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 647.0
TLS2_k127_292875_30 SPTR D1C1B9 DinB family protein - - - 0.000000000000000000000000000000005441 135.0
TLS2_k127_292875_31 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 0.000000000000000000000000000001285 130.0
TLS2_k127_292875_32 nuclease K01174 - 3.1.31.1 0.0000000000000000000000008197 113.0
TLS2_k127_292875_33 - - - - 0.0000000000000000002236 96.0
TLS2_k127_292875_34 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 - - - 0.0000000000003049 72.0
TLS2_k127_292875_35 Manganese containing catalase - - - 0.0002488 47.0
TLS2_k127_292875_4 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 593.0
TLS2_k127_292875_5 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 555.0
TLS2_k127_292875_6 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 511.0
TLS2_k127_292875_7 TIGRFAM LPPG domain protein containing protein K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006187 418.0
TLS2_k127_292875_8 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 404.0
TLS2_k127_292875_9 Belongs to the FPP GGPP synthase family K00805,K02523 - 2.5.1.30,2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003127 401.0
TLS2_k127_2937375_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000007126 112.0
TLS2_k127_2937375_1 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.0000000000000000008477 101.0
TLS2_k127_294890_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 9.178e-292 914.0
TLS2_k127_294890_1 Bacterial PH domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 487.0
TLS2_k127_294890_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008524 402.0
TLS2_k127_294890_3 PFAM metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005906 382.0
TLS2_k127_294890_4 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000000000000000000000000000004011 170.0
TLS2_k127_294890_5 PFAM LysM domain - - - 0.0000000000000000000000000006326 125.0
TLS2_k127_2975245_0 transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 505.0
TLS2_k127_2975245_1 peptidoglycan turnover - - - 0.0000000000000000000000000000000000000000000000000000000000000000246 238.0
TLS2_k127_2975245_2 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000002337 181.0
TLS2_k127_2975245_3 SnoaL-like polyketide cyclase K15945 - - 0.000000000000000000000000000000000000000000161 164.0
TLS2_k127_2975245_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000002372 149.0
TLS2_k127_2975245_5 SnoaL-like domain K06893 - - 0.00000000000000000000000000000000919 133.0
TLS2_k127_2975245_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000007792 129.0
TLS2_k127_2975245_7 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000004007 83.0
TLS2_k127_2975245_8 Major Facilitator Superfamily - - - 0.0000004043 62.0
TLS2_k127_2976731_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 9.325e-242 751.0
TLS2_k127_2976731_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 3.468e-241 751.0
TLS2_k127_2976731_2 Two component transcriptional regulator, winged helix family K07669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 371.0
TLS2_k127_2976731_3 Peptidoglycan-binding LysM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005869 372.0
TLS2_k127_2976731_4 cyclic nucleotide binding K01420,K10914,K22490 GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009416,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019216,GO:0019219,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0042803,GO:0045828,GO:0045834,GO:0045893,GO:0045935,GO:0046889,GO:0046890,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071214,GO:0071478,GO:0071482,GO:0080090,GO:0097159,GO:0104004,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1904143,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 343.0
TLS2_k127_2976731_5 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000004645 190.0
TLS2_k127_2976731_6 Protein of unknown function (DUF1572) - - - 0.00000000000000000000000000000000000006976 147.0
TLS2_k127_2984493_0 Pfam:Arch_ATPase - - - 7.547e-208 687.0
TLS2_k127_2984493_1 transferase activity, transferring glycosyl groups K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 444.0
TLS2_k127_2984493_2 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 429.0
TLS2_k127_2984493_3 - K06921 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008322 376.0
TLS2_k127_2984493_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 360.0
TLS2_k127_2984493_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007234 327.0
TLS2_k127_2984582_0 PFAM glycosyl transferase, family 51 - - - 9.535e-248 771.0
TLS2_k127_2984582_1 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 358.0
TLS2_k127_2984582_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 314.0
TLS2_k127_2987452_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 462.0
TLS2_k127_2987452_1 Alanine-glyoxylate amino-transferase K00375,K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003073 267.0
TLS2_k127_2987452_2 AI-2E family transporter K11744 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000009089 208.0
TLS2_k127_2987452_3 - - - - 0.000000000000000000000000000007239 124.0
TLS2_k127_2987452_4 sh3 domain protein K01448,K04771 - 3.4.21.107,3.5.1.28 0.0000000000000000000004411 110.0
TLS2_k127_2987452_5 - - - - 0.000000000000002388 77.0
TLS2_k127_2987452_6 - - - - 0.0000000002117 61.0
TLS2_k127_2987452_8 2',5' RNA ligase - - - 0.00001842 54.0
TLS2_k127_2987945_0 Adenylylsulphate kinase K00955,K00956 GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0044237 2.7.1.25,2.7.7.4 7.415e-255 801.0
TLS2_k127_2987945_1 PFAM UDP-glucose GDP-mannose dehydrogenase K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006853 609.0
TLS2_k127_2987945_2 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 457.0
TLS2_k127_2987945_3 PFAM short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000608 391.0
TLS2_k127_2987945_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 343.0
TLS2_k127_2987945_5 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000005064 183.0
TLS2_k127_2987945_6 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000005621 154.0
TLS2_k127_2987945_7 TIGRFAM sulfate adenylyltransferase, small subunit K00957 - 2.7.7.4 0.000000000000000000000000000000003595 130.0
TLS2_k127_2987945_8 protein secretion K03116,K03117 - - 0.0000000000000000000004504 96.0
TLS2_k127_2995137_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 2.907e-209 665.0
TLS2_k127_2995137_1 Squalene-hopene cyclase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 364.0
TLS2_k127_2995137_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000007443 261.0
TLS2_k127_2995137_3 transferase activity, transferring alkyl or aryl (other than methyl) groups K15911,K22313 GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016101,GO:0016102,GO:0016114,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0035440,GO:0042578,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0075136,GO:1901576 3.1.7.12,3.1.7.8,3.1.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000006053 246.0
TLS2_k127_2995137_4 Psort location Cytoplasmic, score 7.50 K01250 - - 0.0000000000000000000000000000000009385 148.0
TLS2_k127_2995137_5 phosphatase activity K07025 - - 0.000000000000001225 82.0
TLS2_k127_3022434_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015,K00018 - 1.1.1.26,1.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 371.0
TLS2_k127_3022434_1 PFAM Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 299.0
TLS2_k127_3022434_2 Belongs to the globin family K05916 - 1.14.12.17 0.0000000000005864 70.0
TLS2_k127_3022434_3 Extracellular solute-binding protein K02027 - - 0.000000000001358 80.0
TLS2_k127_3022434_4 Globin - - - 0.0006651 42.0
TLS2_k127_3029125_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008951 436.0
TLS2_k127_3029125_1 Cation transport protein K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 398.0
TLS2_k127_3029125_10 - - - - 0.000369 46.0
TLS2_k127_3029125_2 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 318.0
TLS2_k127_3029125_3 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000001027 240.0
TLS2_k127_3029125_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000004225 228.0
TLS2_k127_3029125_5 domain, Protein K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000008039 210.0
TLS2_k127_3029125_6 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000001716 117.0
TLS2_k127_3029125_8 Copper binding proteins, plastocyanin/azurin family - - - 0.000005806 53.0
TLS2_k127_3029125_9 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000293 53.0
TLS2_k127_303405_0 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 1.261e-208 657.0
TLS2_k127_303405_1 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004609 250.0
TLS2_k127_303405_2 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000008319 262.0
TLS2_k127_303405_3 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000000000008442 164.0
TLS2_k127_303405_4 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.0000000000000000000000000000000000001042 144.0
TLS2_k127_303405_5 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000008248 134.0
TLS2_k127_303405_6 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000001291 92.0
TLS2_k127_303405_7 COG2010 Cytochrome c, mono- and diheme variants K02305 - - 0.000009169 55.0
TLS2_k127_3056059_0 PFAM Lanthionine synthetase - - - 2.6e-303 967.0
TLS2_k127_3056059_1 Peptidase C39 family K06147 - - 1.861e-238 757.0
TLS2_k127_3056059_10 IstB-like ATP binding protein - - - 0.000000000000000000000000000000000000000001143 160.0
TLS2_k127_3056059_11 Belongs to the 'phage' integrase family K04763 - - 0.000000000000000000000000000000000000000003362 164.0
TLS2_k127_3056059_12 - - - - 0.0000000000000000000000000000000000000001147 151.0
TLS2_k127_3056059_13 DNA primase - - - 0.000000000000000000000000000000002808 139.0
TLS2_k127_3056059_14 - - - - 0.0000000000000000000000000000001646 126.0
TLS2_k127_3056059_15 Belongs to the 'phage' integrase family K04763 - - 0.000000000000000000000000000001084 133.0
TLS2_k127_3056059_16 Putative inner membrane protein (DUF1819) - - - 0.00000000000000000000000001335 116.0
TLS2_k127_3056059_17 DDE superfamily endonuclease - - - 0.0000000000000000000000001099 108.0
TLS2_k127_3056059_18 ABC transporter substrate-binding protein K10236 - - 0.00000000000000004238 94.0
TLS2_k127_3056059_19 COG3335 Transposase and inactivated derivatives - - - 0.00000000000000396 81.0
TLS2_k127_3056059_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 454.0
TLS2_k127_3056059_20 TIGRFAM type 2 lantibiotic, mersacidin lichenicidin family - - - 0.000000000631 64.0
TLS2_k127_3056059_21 transcriptional regulator K03556 - - 0.00000001807 57.0
TLS2_k127_3056059_22 - - - - 0.0000008977 53.0
TLS2_k127_3056059_23 - - - - 0.000006224 59.0
TLS2_k127_3056059_24 Single-strand binding protein family K03111 - - 0.00006465 48.0
TLS2_k127_3056059_25 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0002084 52.0
TLS2_k127_3056059_26 Replication-relaxation - - - 0.0009361 51.0
TLS2_k127_3056059_3 carbohydrate transport K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007231 276.0
TLS2_k127_3056059_4 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001111 260.0
TLS2_k127_3056059_5 ABC transporter permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007973 252.0
TLS2_k127_3056059_6 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.0000000000000000000000000000000000000000000000000000004193 201.0
TLS2_k127_3056059_7 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000006844 178.0
TLS2_k127_3056059_8 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000002171 168.0
TLS2_k127_3056059_9 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000002507 163.0
TLS2_k127_3056762_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.85e-211 666.0
TLS2_k127_3056762_1 COG1312 D-mannonate dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 340.0
TLS2_k127_3056762_2 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 319.0
TLS2_k127_3056762_3 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007799 264.0
TLS2_k127_3070064_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000682 495.0
TLS2_k127_3070064_1 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 385.0
TLS2_k127_3070064_10 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000005234 238.0
TLS2_k127_3070064_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 380.0
TLS2_k127_3070064_3 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 372.0
TLS2_k127_3070064_4 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 366.0
TLS2_k127_3070064_5 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 370.0
TLS2_k127_3070064_6 ABC transporter substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 348.0
TLS2_k127_3070064_7 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 331.0
TLS2_k127_3070064_8 ABC-type dipeptide oligopeptide nickel transport K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 291.0
TLS2_k127_3070064_9 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000287 280.0
TLS2_k127_3074171_0 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369,K13890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 307.0
TLS2_k127_3074171_1 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008227 298.0
TLS2_k127_3074171_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000002843 194.0
TLS2_k127_3074171_3 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000002033 100.0
TLS2_k127_3084995_0 bacterial-type flagellum-dependent cell motility - - - 0.0 1662.0
TLS2_k127_3084995_1 bacterial-type flagellum-dependent cell motility - - - 0.0000000006458 60.0
TLS2_k127_309137_0 PFAM magnesium chelatase ChlI subunit K07391 - - 7.961e-229 719.0
TLS2_k127_309137_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K01042 - 2.9.1.1 3.053e-209 663.0
TLS2_k127_309137_10 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 294.0
TLS2_k127_309137_11 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002708 281.0
TLS2_k127_309137_12 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002567 273.0
TLS2_k127_309137_13 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000009253 261.0
TLS2_k127_309137_14 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000000000000000000000000000000000000000000000003255 229.0
TLS2_k127_309137_15 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000000000000000000000000000000000000000000000002291 209.0
TLS2_k127_309137_16 BNR repeat-like domain K01186 - 3.2.1.18 0.000000000000000000000000000000000000000000000002357 190.0
TLS2_k127_309137_17 family 5 K02035 - - 0.0000000000000000000000000000000000000000000002986 187.0
TLS2_k127_309137_18 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000003094 187.0
TLS2_k127_309137_19 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000003376 179.0
TLS2_k127_309137_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 603.0
TLS2_k127_309137_20 Rieske-like [2Fe-2S] domain - - - 0.000000000000000000000000000000002501 134.0
TLS2_k127_309137_22 Dystroglycan-type cadherin-like domains. - - - 0.0000000000000000000000000005531 132.0
TLS2_k127_309137_23 Glyoxalase-like domain - - - 0.0000000000000000000000000009445 119.0
TLS2_k127_309137_24 Psort location Cytoplasmic, score 8.87 - - - 0.0000000000000000000000003254 115.0
TLS2_k127_309137_25 - - - - 0.00000000000000000006455 102.0
TLS2_k127_309137_26 Alcohol dehydrogenase GroES-like domain K00060,K18369 - 1.1.1.103 0.000000000000000000168 100.0
TLS2_k127_309137_27 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000002375 90.0
TLS2_k127_309137_28 GlcNAc-PI de-N-acetylase K16515 - 4.2.1.83 0.00000000000001603 84.0
TLS2_k127_309137_29 Amidohydrolase - - - 0.00000007205 63.0
TLS2_k127_309137_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 586.0
TLS2_k127_309137_31 exo-alpha-(2->6)-sialidase activity - - - 0.0000002878 63.0
TLS2_k127_309137_32 BNR repeat-like domain - - - 0.00006779 55.0
TLS2_k127_309137_4 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007248 527.0
TLS2_k127_309137_5 FMN-dependent dehydrogenase K00101,K15054 - 1.1.2.3,1.1.99.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 437.0
TLS2_k127_309137_6 Zinc-binding dehydrogenase K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 387.0
TLS2_k127_309137_7 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 372.0
TLS2_k127_309137_8 M42 glutamyl aminopeptidase K01258 - 3.4.11.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 311.0
TLS2_k127_309137_9 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007825 300.0
TLS2_k127_3119088_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 4.778e-320 987.0
TLS2_k127_3119088_1 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 537.0
TLS2_k127_3119088_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001207 269.0
TLS2_k127_3119088_4 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.0000000000000000000000000000000000000000001446 163.0
TLS2_k127_3124028_0 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 1.65e-296 914.0
TLS2_k127_3124028_1 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 6.066e-293 902.0
TLS2_k127_3124028_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005606 586.0
TLS2_k127_3124028_3 PFAM regulatory protein, ArsR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009449 256.0
TLS2_k127_3124028_4 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000000000000000000000000000006759 197.0
TLS2_k127_3124028_5 PFAM nitrogen-fixing NifU domain protein - - - 0.0000000000000000000000000000000000131 138.0
TLS2_k127_3124028_6 PFAM Rhodanese-like domain - - - 0.00000000000000000001256 96.0
TLS2_k127_3138373_0 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008009 370.0
TLS2_k127_3138373_1 Methyltransferase type 12 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002554 244.0
TLS2_k127_3138373_2 SPTR D1C1B9 DinB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001369 235.0
TLS2_k127_3138373_3 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.000000000000000000000000000000000000000001113 169.0
TLS2_k127_3138373_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000001607 169.0
TLS2_k127_3138373_5 Tetratricopeptide repeat - - - 0.000000000000000000000002914 111.0
TLS2_k127_3151193_0 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 2.927e-198 651.0
TLS2_k127_3151193_1 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002901 242.0
TLS2_k127_3151193_2 competence protein - - - 0.00000000000000000000000000000000000000000000000000000000000002821 222.0
TLS2_k127_3157818_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 447.0
TLS2_k127_3157818_1 Transposase, Mutator family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 408.0
TLS2_k127_3157818_2 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001573 281.0
TLS2_k127_3157818_3 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007013 258.0
TLS2_k127_3157818_4 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001655 259.0
TLS2_k127_3157818_5 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000006999 225.0
TLS2_k127_3157818_6 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000001052 154.0
TLS2_k127_3157818_7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281,K09020 - 3.5.1.110,3.5.1.19 0.000000000000000000000000008251 115.0
TLS2_k127_3157818_8 Phosphotransferase enzyme family - - - 0.000000001145 69.0
TLS2_k127_3157818_9 PFAM transposase mutator type - - - 0.00002357 51.0
TLS2_k127_3190189_0 Nitrite and sulphite reductase 4Fe-4S domain K00392 - 1.8.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 598.0
TLS2_k127_3190189_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 443.0
TLS2_k127_3190189_2 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 354.0
TLS2_k127_3190189_3 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 315.0
TLS2_k127_3190189_4 Belongs to the PAPS reductase family. CysH subfamily K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000003622 235.0
TLS2_k127_3194357_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 602.0
TLS2_k127_3194357_1 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000005349 214.0
TLS2_k127_3196658_0 PFAM ATP-binding region, ATPase domain protein K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 451.0
TLS2_k127_3196658_1 Two component transcriptional regulator, winged helix family K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 361.0
TLS2_k127_3196658_10 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000001589 160.0
TLS2_k127_3196658_11 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000001183 150.0
TLS2_k127_3196658_12 dehydrogenases and related proteins - - - 0.00000000000000000000000002051 123.0
TLS2_k127_3196658_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 318.0
TLS2_k127_3196658_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 307.0
TLS2_k127_3196658_4 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009593 261.0
TLS2_k127_3196658_5 Aldo Keto reductase K05882 - 1.1.1.91 0.00000000000000000000000000000000000000000000000000000000000000000000000001945 260.0
TLS2_k127_3196658_6 inositol 2-dehydrogenase activity K18067 - 1.3.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000003843 256.0
TLS2_k127_3196658_7 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000271 260.0
TLS2_k127_3196658_8 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000001855 231.0
TLS2_k127_3196658_9 family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000001932 222.0
TLS2_k127_3200215_0 WD domain, G-beta repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006954 399.0
TLS2_k127_3200215_1 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 305.0
TLS2_k127_3200215_2 heme binding K21471 - - 0.00000000000000000000000000000000000000000000000000000000004475 235.0
TLS2_k127_3200215_3 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000001782 218.0
TLS2_k127_3200215_4 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000006278 189.0
TLS2_k127_3200215_5 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000008107 160.0
TLS2_k127_3200215_6 cysteine-type peptidase activity K01181,K01227 - 3.2.1.8,3.2.1.96 0.000000000000000000000001351 122.0
TLS2_k127_3200215_7 Belongs to the glycosyl hydrolase 5 (cellulase A) family K19355 - 3.2.1.78 0.00000005913 67.0
TLS2_k127_3206664_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 520.0
TLS2_k127_3206664_1 Bacterial extracellular solute-binding protein K10200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004612 350.0
TLS2_k127_3206664_2 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000376 321.0
TLS2_k127_3206664_3 PFAM peptidase, membrane zinc metallopeptidase K06973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 287.0
TLS2_k127_3206664_4 ECF transporter, substrate-specific component - - - 0.000000000000000000000000000000000000000000000000000119 191.0
TLS2_k127_3206664_5 sh3 domain protein K12132,K15539 - 2.7.11.1 0.00003284 56.0
TLS2_k127_3206664_6 Sugar ABC transporter ATP-binding protein - - - 0.0008668 42.0
TLS2_k127_3208142_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1714.0
TLS2_k127_3208142_1 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 0.0 1049.0
TLS2_k127_3208142_10 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 368.0
TLS2_k127_3208142_12 PFAM LmbE family protein K18455 - 3.5.1.115 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 343.0
TLS2_k127_3208142_13 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 323.0
TLS2_k127_3208142_14 SMART HNH nuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000218 280.0
TLS2_k127_3208142_15 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007935 273.0
TLS2_k127_3208142_16 PFAM diacylglycerol kinase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001832 267.0
TLS2_k127_3208142_17 glycosyl transferase group 1 K08256 - 2.4.1.345 0.00000000000000000000000000000000000000000000000000000000000000000000001571 256.0
TLS2_k127_3208142_18 Threonyl alanyl tRNA synthetase SAD K01872,K07050 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000001149 230.0
TLS2_k127_3208142_19 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000000000000000001608 220.0
TLS2_k127_3208142_2 ABC transporter C-terminal domain K15738 - - 3.072e-241 760.0
TLS2_k127_3208142_21 positive regulation of growth rate - - - 0.000000000000000000000000000000000000000000000002584 188.0
TLS2_k127_3208142_22 - - - - 0.00000000000000000000000000000000000000000000262 167.0
TLS2_k127_3208142_23 Protein of unknown function (DUF983) - - - 0.0000000000000000000000000000000000000873 145.0
TLS2_k127_3208142_24 PFAM response regulator receiver - - - 0.0000000000000000000000000000007082 126.0
TLS2_k127_3208142_25 Bacterial protein of unknown function (DUF951) - - - 0.00000000000000000000001665 102.0
TLS2_k127_3208142_26 COGs COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductase K19745 - - 0.000000000000003443 79.0
TLS2_k127_3208142_27 Rdx family K07401 - - 0.0000000000004346 71.0
TLS2_k127_3208142_28 Polymer-forming cytoskeletal - - - 0.0000001339 64.0
TLS2_k127_3208142_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 1.85e-205 649.0
TLS2_k127_3208142_4 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 585.0
TLS2_k127_3208142_5 aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 568.0
TLS2_k127_3208142_6 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 539.0
TLS2_k127_3208142_7 sh3 domain protein K15539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 530.0
TLS2_k127_3208142_8 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 487.0
TLS2_k127_3208142_9 Putative nucleotide-binding of sugar-metabolising enzyme K22129 - 2.7.1.219,2.7.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 445.0
TLS2_k127_321469_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 579.0
TLS2_k127_321469_1 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 446.0
TLS2_k127_321469_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000007131 221.0
TLS2_k127_32193_0 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 1.842e-223 701.0
TLS2_k127_32193_1 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 407.0
TLS2_k127_32193_2 PFAM Abortive infection protein K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000943 278.0
TLS2_k127_32193_4 Domain of unknown function (DUF1992) K19373 - - 0.00000000000000000000000000004403 125.0
TLS2_k127_3225294_0 May be involved in recombinational repair of damaged DNA K03631 - - 6.574e-248 779.0
TLS2_k127_3225294_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 608.0
TLS2_k127_3225294_10 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls - - - 0.00002219 50.0
TLS2_k127_3225294_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 533.0
TLS2_k127_3225294_3 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 459.0
TLS2_k127_3225294_4 Uncharacterized protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007947 336.0
TLS2_k127_3225294_5 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 295.0
TLS2_k127_3225294_6 protein secretion K03116 - - 0.00000000000002515 76.0
TLS2_k127_3225294_7 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.00000000000003351 74.0
TLS2_k127_3225294_8 Methyltransferase domain - - - 0.000000109 61.0
TLS2_k127_3231739_0 COGs COG4591 ABC-type transport system involved in lipoprotein release permease component K02004 - - 4.967e-316 1012.0
TLS2_k127_3231739_1 Psort location CytoplasmicMembrane, score - - - 2.6e-231 739.0
TLS2_k127_3231739_10 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000000000000000000000436 160.0
TLS2_k127_3231739_11 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000003917 151.0
TLS2_k127_3231739_13 Transglycosylase associated protein - - - 0.0000000000000000000000000000002497 124.0
TLS2_k127_3231739_2 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 610.0
TLS2_k127_3231739_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 437.0
TLS2_k127_3231739_4 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 379.0
TLS2_k127_3231739_5 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 320.0
TLS2_k127_3231739_6 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000984 320.0
TLS2_k127_3231739_7 PFAM Formiminotransferase-cyclodeaminase - - - 0.000000000000000000000000000000000000000000000000000000000000000001474 236.0
TLS2_k127_3231739_8 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000009513 213.0
TLS2_k127_3231739_9 guanyl-nucleotide exchange factor activity - - - 0.00000000000000000000000000000000000000000002166 177.0
TLS2_k127_3234480_0 elongation factor Tu domain 2 protein K02355 - - 8.045e-309 960.0
TLS2_k127_3234480_1 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 479.0
TLS2_k127_3234480_2 methyltransferase K00850,K01834,K15634 - 2.7.1.11,5.4.2.11,5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 419.0
TLS2_k127_3234480_4 Aminoacyl-tRNA editing domain K03976 - - 0.00000000000000000000000000000000000000000002579 171.0
TLS2_k127_3234480_6 T COG0642 Signal transduction histidine kinase - - - 0.00007796 47.0
TLS2_k127_3254339_0 (ABC) transporter K06147,K11085 - - 2.062e-234 738.0
TLS2_k127_3254339_1 - - - - 1.184e-217 691.0
TLS2_k127_3254339_10 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 312.0
TLS2_k127_3254339_11 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003918 301.0
TLS2_k127_3254339_12 TIGRFAM RarD protein, DMT superfamily transporter K05786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000162 285.0
TLS2_k127_3254339_13 mandelate racemase muconate lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001677 272.0
TLS2_k127_3254339_14 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002826 269.0
TLS2_k127_3254339_15 PFAM Xylose isomerase domain protein TIM barrel K00457,K06606 - 1.13.11.27,5.3.99.11 0.00000000000000000000000000000000000000000000000000000000000000000000004039 250.0
TLS2_k127_3254339_16 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001153 249.0
TLS2_k127_3254339_17 Malate/L-lactate dehydrogenase K00073,K13574 - 1.1.1.350 0.000000000000000000000000000000000000000000000000000000000000000003831 238.0
TLS2_k127_3254339_18 rRNA (adenine-N6,N6-)-dimethyltransferase activity K00561,K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.184 0.00000000000000000000000000000000000000000000000000000000006768 217.0
TLS2_k127_3254339_19 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000000000000000000001801 209.0
TLS2_k127_3254339_2 sulfuric ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 457.0
TLS2_k127_3254339_20 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000004596 201.0
TLS2_k127_3254339_21 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000000004851 210.0
TLS2_k127_3254339_22 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000004335 201.0
TLS2_k127_3254339_23 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000637 173.0
TLS2_k127_3254339_25 Oxidoreductase, aldo keto reductase family protein - - - 0.000000005812 63.0
TLS2_k127_3254339_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K01497,K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005186 424.0
TLS2_k127_3254339_4 Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 376.0
TLS2_k127_3254339_5 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 377.0
TLS2_k127_3254339_6 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000707 366.0
TLS2_k127_3254339_7 major facilitator superfamily MFS_1 K08225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 342.0
TLS2_k127_3254339_8 PFAM alanine racemase domain protein K20757 - 4.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 331.0
TLS2_k127_3254339_9 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 326.0
TLS2_k127_3283955_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 499.0
TLS2_k127_3283955_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 463.0
TLS2_k127_3283955_2 Family 4 glycosyl hydrolase K01222,K07406 - 3.2.1.22,3.2.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009941 428.0
TLS2_k127_3283955_3 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008179 389.0
TLS2_k127_3283955_4 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 302.0
TLS2_k127_3283955_5 PFAM transposase, mutator type - - - 0.000000000000000000000000000000000000000000000000000000000000000008121 230.0
TLS2_k127_3283955_6 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000001344 184.0
TLS2_k127_3283955_7 transposase activity K07493 - - 0.0000006633 59.0
TLS2_k127_3283955_8 - - - - 0.0004005 46.0
TLS2_k127_3290844_0 Binding-protein-dependent transport system inner membrane component K02063 - - 1.945e-198 632.0
TLS2_k127_3290844_1 Bacterial extracellular solute-binding protein K02064 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 489.0
TLS2_k127_3290844_2 ATPase activity K02010,K02052,K02062,K11072 - 3.6.3.30,3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 334.0
TLS2_k127_3290844_3 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.0000000000000000000000000000000000000000000000000000000008133 228.0
TLS2_k127_3290844_4 Zincin-like metallopeptidase - - - 0.00000000000000000000000000000000000000000000001921 173.0
TLS2_k127_3296201_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III domain protein K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 546.0
TLS2_k127_3296201_1 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 541.0
TLS2_k127_3296201_2 Trypsin-like peptidase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 385.0
TLS2_k127_3296201_3 Proton-conducting membrane transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000008283 241.0
TLS2_k127_3333459_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1139.0
TLS2_k127_3333459_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 7.613e-311 977.0
TLS2_k127_3333459_10 PFAM regulatory protein, MerR - - - 0.000000000000000000000000000000000000000000000000000000000000000267 228.0
TLS2_k127_3333459_11 inositol 2-dehydrogenase activity K19181 - 1.1.1.292 0.000000000000000000000000000000000000000000000000000000000000003033 231.0
TLS2_k127_3333459_12 regulation of cell shape K04074,K07484,K17763,K18682,K21471 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 - 0.000000000000000000000000000000000000000000004854 186.0
TLS2_k127_3333459_13 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000000000000000000000000000002825 156.0
TLS2_k127_3333459_14 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000000000001549 126.0
TLS2_k127_3333459_16 isoprenoid biosynthetic process K00805,K02523 - 2.5.1.30,2.5.1.90 0.00000000000000000009304 100.0
TLS2_k127_3333459_17 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000009717 77.0
TLS2_k127_3333459_2 PFAM regulatory protein, MerR K22491 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 409.0
TLS2_k127_3333459_3 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 403.0
TLS2_k127_3333459_4 PFAM PfkB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 394.0
TLS2_k127_3333459_5 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 362.0
TLS2_k127_3333459_6 PFAM 60 kDa inner membrane insertion protein K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 353.0
TLS2_k127_3333459_7 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006784 259.0
TLS2_k127_3333459_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000009668 241.0
TLS2_k127_3333459_9 PFAM single-stranded nucleic acid binding R3H domain protein K06346 - - 0.000000000000000000000000000000000000000000000000000000000000000000001422 246.0
TLS2_k127_333483_0 PFAM Anion-transporting ATPase K01551 - 3.6.3.16 4.487e-211 662.0
TLS2_k127_333483_1 Belongs to the peptidase S8 family K13276 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 500.0
TLS2_k127_333483_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000003541 231.0
TLS2_k127_333483_3 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0000000000000000000000000000000000000000000000008548 177.0
TLS2_k127_333483_4 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.0000000000000000000000000000000000000000000001914 173.0
TLS2_k127_333483_5 with the alpha beta hydrolase fold K01046 - 3.1.1.3 0.000000000000000000000000000000000000000003177 162.0
TLS2_k127_333483_6 Elongation factor Tu C-terminal domain K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000005683 122.0
TLS2_k127_333483_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000003236 113.0
TLS2_k127_3351425_0 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 562.0
TLS2_k127_3351425_1 NAD binding K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 363.0
TLS2_k127_3351425_2 phosphatase activity K07025,K20862 - 3.1.3.102,3.1.3.104 0.00000000000000000000001055 105.0
TLS2_k127_3353175_0 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008114 444.0
TLS2_k127_3353175_1 WD-40 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000219 303.0
TLS2_k127_336529_0 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 335.0
TLS2_k127_336529_1 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 324.0
TLS2_k127_336529_2 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 317.0
TLS2_k127_336529_3 carbohydrate transport K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007346 302.0
TLS2_k127_336529_4 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000001537 239.0
TLS2_k127_336529_5 methyltransferase - - - 0.0000000000000000000000000000001016 135.0
TLS2_k127_336529_6 Cupin domain - - - 0.00000000000005288 72.0
TLS2_k127_3371332_0 depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 326.0
TLS2_k127_3371332_1 PFAM Methionine sulfoxide reductase B K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008006 268.0
TLS2_k127_3371332_2 serine-type aminopeptidase activity K14475 - - 0.0000000000005054 79.0
TLS2_k127_3371332_3 Chitinase class I K03791 - - 0.0000004864 61.0
TLS2_k127_337217_0 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 0.0 1221.0
TLS2_k127_337217_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0 1065.0
TLS2_k127_337217_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 558.0
TLS2_k127_337217_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 444.0
TLS2_k127_337217_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 299.0
TLS2_k127_337217_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000001094 119.0
TLS2_k127_337217_6 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000001061 103.0
TLS2_k127_3385613_0 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 507.0
TLS2_k127_3385613_1 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 490.0
TLS2_k127_3385613_10 belongs to the nudix hydrolase family - - - 0.000001229 52.0
TLS2_k127_3385613_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 421.0
TLS2_k127_3385613_3 Catalytic domain of components of various dehydrogenase complexes K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 388.0
TLS2_k127_3385613_4 virulence factor MVIN family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 345.0
TLS2_k127_3385613_5 Peptidase_C39 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 336.0
TLS2_k127_3385613_6 domain protein K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 324.0
TLS2_k127_3385613_7 endonuclease III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001139 245.0
TLS2_k127_3385613_8 PFAM ROK family protein K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000005964 190.0
TLS2_k127_3385613_9 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000003252 98.0
TLS2_k127_3389606_0 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 317.0
TLS2_k127_3389606_1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000318 218.0
TLS2_k127_3389606_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000003833 217.0
TLS2_k127_3389606_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000001389 132.0
TLS2_k127_3394522_0 von Willebrand factor (vWF) type D domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001017 280.0
TLS2_k127_3394522_1 Belongs to the UPF0337 (CsbD) family - - - 0.0000000000000000001276 104.0
TLS2_k127_3394522_2 - - - - 0.0000000000000004413 91.0
TLS2_k127_3394522_3 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000005082 74.0
TLS2_k127_3394522_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00001302 52.0
TLS2_k127_3409100_0 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007654 381.0
TLS2_k127_3409100_1 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 291.0
TLS2_k127_3409100_2 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000006333 237.0
TLS2_k127_3409100_3 domain, Protein - - - 0.0000000000000000000000000000000000000004862 174.0
TLS2_k127_3409100_4 PFAM Septum formation initiator K05589,K13052 - - 0.00002833 54.0
TLS2_k127_3411478_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 569.0
TLS2_k127_3417463_0 PFAM single-stranded nucleic acid binding R3H domain protein - - - 8.04e-244 766.0
TLS2_k127_3417463_1 Predicted membrane protein (DUF2079) - - - 9.42e-240 766.0
TLS2_k127_3417463_10 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 329.0
TLS2_k127_3417463_11 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 314.0
TLS2_k127_3417463_12 PFAM lipopolysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 302.0
TLS2_k127_3417463_13 Lipopolysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001419 283.0
TLS2_k127_3417463_14 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004159 269.0
TLS2_k127_3417463_15 protein tyrosine kinase activity K08253,K16554 - 2.7.10.2 0.0000000000000000000000000000000000000000000000000000000000000000000000004948 252.0
TLS2_k127_3417463_17 Pfam SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001562 231.0
TLS2_k127_3417463_19 Cyclic-di-AMP receptor - - - 0.00000000000000000000000000000000000000000000000001022 181.0
TLS2_k127_3417463_2 metal-dependent phosphohydrolase, HD sub domain K07037 - - 5.929e-231 739.0
TLS2_k127_3417463_20 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000007811 160.0
TLS2_k127_3417463_21 PFAM diacylglycerol kinase K00901 - 2.7.1.107 0.000000000000000000000000000000000002414 142.0
TLS2_k127_3417463_23 carbon-nitrogen ligase activity, with glutamine as amido-N-donor K09117 - - 0.00000000000000000000000000000000004051 139.0
TLS2_k127_3417463_24 Acetyltransferase (GNAT) domain - - - 0.000000001591 68.0
TLS2_k127_3417463_3 PFAM Nucleotidyl transferase K00973 - 2.7.7.24 4.762e-200 626.0
TLS2_k127_3417463_4 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 592.0
TLS2_k127_3417463_5 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 583.0
TLS2_k127_3417463_6 D-arabinono-1,4-lactone oxidase K00103,K00594 - 1.1.3.41,1.1.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 503.0
TLS2_k127_3417463_7 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 494.0
TLS2_k127_3417463_8 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K01501 - 3.5.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 358.0
TLS2_k127_3417463_9 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 332.0
TLS2_k127_3434329_0 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000000000000007067 135.0
TLS2_k127_3434329_1 Belongs to the 'phage' integrase family K04763 - - 0.000000000000000000000000001883 123.0
TLS2_k127_3434329_3 Replication-relaxation - - - 0.000009884 57.0
TLS2_k127_3438909_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1218.0
TLS2_k127_3438909_1 SMART phosphoesterase PHP domain protein - - - 6.266e-255 799.0
TLS2_k127_3438909_2 ABC transporter, transmembrane region K06147 - - 2.964e-245 770.0
TLS2_k127_3438909_3 PFAM UbiA prenyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 380.0
TLS2_k127_3438909_4 Ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 325.0
TLS2_k127_3438909_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000002983 232.0
TLS2_k127_3438909_6 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000007638 173.0
TLS2_k127_3441502_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.0 1581.0
TLS2_k127_3441502_1 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 402.0
TLS2_k127_3441502_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 381.0
TLS2_k127_3441502_3 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032,K10823,K10824 - 3.6.3.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 363.0
TLS2_k127_3441502_4 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001988 280.0
TLS2_k127_3441502_5 acetyltransferase - - - 0.00001538 55.0
TLS2_k127_3443672_0 oligosaccharyl transferase activity - - - 0.0 1090.0
TLS2_k127_3443672_1 PFAM amine oxidase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 3.117e-258 803.0
TLS2_k127_3443672_10 Serine threonine protein kinase K08884 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 442.0
TLS2_k127_3443672_11 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 386.0
TLS2_k127_3443672_12 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 344.0
TLS2_k127_3443672_13 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000001044 249.0
TLS2_k127_3443672_14 LexA-binding, inner membrane-associated putative hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001365 248.0
TLS2_k127_3443672_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001401 252.0
TLS2_k127_3443672_16 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000000006019 149.0
TLS2_k127_3443672_17 COGs COG2226 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.000000000000000000000000000001468 131.0
TLS2_k127_3443672_18 transcriptional regulator K03892 - - 0.0000000000000000000000000001321 120.0
TLS2_k127_3443672_19 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0000000000000000000000005259 111.0
TLS2_k127_3443672_2 ABC transporter substrate-binding protein PnrA-like K02058,K07335 - - 1.599e-206 648.0
TLS2_k127_3443672_20 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.0000000000000001889 92.0
TLS2_k127_3443672_21 virulence factor MVIN family protein - - - 0.0000000001483 63.0
TLS2_k127_3443672_3 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 8.722e-206 651.0
TLS2_k127_3443672_4 modification enzyme, MiaB family K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 603.0
TLS2_k127_3443672_5 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 549.0
TLS2_k127_3443672_6 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 522.0
TLS2_k127_3443672_7 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 517.0
TLS2_k127_3443672_8 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 493.0
TLS2_k127_3443672_9 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 492.0
TLS2_k127_3462074_0 Ntpase (Nacht family) K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 377.0
TLS2_k127_3462074_1 PFAM NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 312.0
TLS2_k127_3462074_2 4-phosphoerythronate dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 292.0
TLS2_k127_3462074_3 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000004492 228.0
TLS2_k127_3462074_4 Sulfatase-modifying factor enzyme 1 K18912 - 1.14.99.50 0.000000000000000000000000000000000000000000000000002687 201.0
TLS2_k127_3462074_5 - - - - 0.000000000000000000000000001426 121.0
TLS2_k127_3462074_6 Domain of unknown function (DUF4399) - - - 0.0000000000000000000007363 106.0
TLS2_k127_3462074_7 Psort location Cytoplasmic, score - - - 0.0000000000000000002917 93.0
TLS2_k127_3462074_8 Acetyltransferase (GNAT) family - - - 0.0000000000000001841 86.0
TLS2_k127_3462074_9 Bulb-type mannose-specific lectin - - - 0.000018 56.0
TLS2_k127_3465668_0 Glucuronate isomerase K01812 - 5.3.1.12 7.354e-206 650.0
TLS2_k127_3465668_1 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 605.0
TLS2_k127_3465668_2 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000002291 102.0
TLS2_k127_3473850_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1204.0
TLS2_k127_3473850_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 474.0
TLS2_k127_3473850_2 transposase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 455.0
TLS2_k127_3473850_3 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000001879 201.0
TLS2_k127_3473850_4 - - - - 0.0000000000002072 77.0
TLS2_k127_3486388_0 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 344.0
TLS2_k127_3486388_1 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008635 299.0
TLS2_k127_3486388_2 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 298.0
TLS2_k127_3486388_3 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004983 259.0
TLS2_k127_3486388_4 Belongs to the HpcH HpaI aldolase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.0000000000000000000000000000000000000000000000000000004911 203.0
TLS2_k127_3486388_5 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000001259 198.0
TLS2_k127_3486388_6 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000414 185.0
TLS2_k127_3486388_7 solute-binding protein K02027 - - 0.000000000000000000000000001457 123.0
TLS2_k127_3493729_0 Phage tail sheath C-terminal domain K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007244 551.0
TLS2_k127_3493729_1 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 482.0
TLS2_k127_3493729_10 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000212 209.0
TLS2_k127_3493729_11 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000001275 194.0
TLS2_k127_3493729_12 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000002646 180.0
TLS2_k127_3493729_13 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000000000004722 166.0
TLS2_k127_3493729_14 Phage tail sheath protein subtilisin-like domain - - - 0.000000000000000000000000000000000000002029 154.0
TLS2_k127_3493729_15 trisaccharide binding K11912 - 2.7.11.1 0.00000000000000000000000000000009674 143.0
TLS2_k127_3493729_16 Protein of unknown function (DUF4255) - - - 0.00000000000000000000000000001002 125.0
TLS2_k127_3493729_17 Binding-protein-dependent transport system inner membrane component K02026,K17317 - - 0.00000000000000000000007774 99.0
TLS2_k127_3493729_18 PFAM binding-protein-dependent transport systems inner membrane component K17317 - - 0.00000000000001318 74.0
TLS2_k127_3493729_19 - - - - 0.0000000000002741 71.0
TLS2_k127_3493729_2 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 437.0
TLS2_k127_3493729_20 Sensor protein DegS K07777 - 2.7.13.3 0.00000000001655 67.0
TLS2_k127_3493729_21 CAAX protease self-immunity K07052 - - 0.0000000001658 68.0
TLS2_k127_3493729_22 Cell Wall K01448 - 3.5.1.28 0.000002717 61.0
TLS2_k127_3493729_3 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 421.0
TLS2_k127_3493729_4 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 308.0
TLS2_k127_3493729_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004131 281.0
TLS2_k127_3493729_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003173 248.0
TLS2_k127_3493729_7 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000006986 226.0
TLS2_k127_3493729_8 geranylgeranyl reductase activity K14266 - 1.14.19.9 0.00000000000000000000000000000000000000000000000000000000000001426 232.0
TLS2_k127_3493729_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000003089 238.0
TLS2_k127_3498315_0 ATPase AAA-2 domain protein K03696 - - 0.0 1428.0
TLS2_k127_3498315_1 PFAM secretion protein HlyD family protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 493.0
TLS2_k127_3498315_2 6-phosphogluconate dehydrogenase, NAD-binding K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 453.0
TLS2_k127_3498315_3 NADPH:quinone reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 372.0
TLS2_k127_3498315_4 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 355.0
TLS2_k127_3498315_5 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 355.0
TLS2_k127_3498315_6 Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002444 270.0
TLS2_k127_3498315_8 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.0009014 46.0
TLS2_k127_3514928_0 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 462.0
TLS2_k127_3514928_1 xylulokinase activity K00848,K00851,K00854 - 2.7.1.12,2.7.1.17,2.7.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 441.0
TLS2_k127_3514928_2 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 380.0
TLS2_k127_3514928_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 354.0
TLS2_k127_3514928_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000009658 194.0
TLS2_k127_3514928_5 L-seryl-tRNA selenium transferase - - - 0.00000000000000000000000000000000000000000000008738 185.0
TLS2_k127_3514928_6 Zinc metalloprotease (Elastase) K01186,K05994,K21449 - 3.2.1.18,3.4.11.10 0.0000000000000000000001089 115.0
TLS2_k127_3514928_7 Protein of unknown function (DUF1706) - - - 0.00000000000000000007148 96.0
TLS2_k127_3514928_8 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.000000009002 69.0
TLS2_k127_3565663_0 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 3.951e-264 820.0
TLS2_k127_3565663_1 PFAM ABC transporter related K10112 - - 3.96e-216 673.0
TLS2_k127_3565663_10 PFAM Ornithine cyclodeaminase mu-crystallin K01750,K19244 - 1.4.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 383.0
TLS2_k127_3565663_11 Protein of unknown function (DUF1679) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 342.0
TLS2_k127_3565663_12 oxidoreductase activity, acting on CH-OH group of donors K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 314.0
TLS2_k127_3565663_13 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 298.0
TLS2_k127_3565663_14 PFAM peptidase M55 D-aminopeptidase K16203 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008051 279.0
TLS2_k127_3565663_15 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007258 290.0
TLS2_k127_3565663_16 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000436 241.0
TLS2_k127_3565663_17 proteolysis K19225 - 3.4.21.105 0.000000000000000000000000000000000000000000000000000000000000000000007924 244.0
TLS2_k127_3565663_18 peptidase C60 sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000000000000000000000000000000000000000000000112 233.0
TLS2_k127_3565663_19 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000002911 220.0
TLS2_k127_3565663_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 1.358e-195 625.0
TLS2_k127_3565663_20 PIN domain - - - 0.000000000000000000000000000000000000000000000000000777 185.0
TLS2_k127_3565663_21 Domain of unknown function (DUF1932) - - - 0.000000000000000000000000000000000000000000000000009105 191.0
TLS2_k127_3565663_22 Putative regulatory protein - - - 0.00000000000000000000000000000000000000000000007296 174.0
TLS2_k127_3565663_23 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000001588 169.0
TLS2_k127_3565663_24 - - - - 0.0000000000000000000000000000000000000001513 166.0
TLS2_k127_3565663_25 methyltransferase - - - 0.00000000000000000000008499 100.0
TLS2_k127_3565663_26 - - - - 0.0000000000006515 73.0
TLS2_k127_3565663_27 nucleotidyltransferase activity K07075 - - 0.00000004609 59.0
TLS2_k127_3565663_28 Domain of unknown function (DUF4037) - - - 0.00006358 54.0
TLS2_k127_3565663_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006185 581.0
TLS2_k127_3565663_4 Peptidase dimerisation domain protein K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 471.0
TLS2_k127_3565663_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007413 460.0
TLS2_k127_3565663_6 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 457.0
TLS2_k127_3565663_7 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 448.0
TLS2_k127_3565663_8 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 404.0
TLS2_k127_3565663_9 kinase activity K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 397.0
TLS2_k127_3600510_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.863e-220 701.0
TLS2_k127_3600510_1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 371.0
TLS2_k127_3600510_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000004431 210.0
TLS2_k127_3600510_3 inorganic diphosphatase activity K01507 - 3.6.1.1 0.00000000000000000000000000001374 120.0
TLS2_k127_3600510_4 InterPro IPR007367 - - - 0.000000000000000000006799 94.0
TLS2_k127_3603203_0 NB-ARC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 500.0
TLS2_k127_3603203_1 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 421.0
TLS2_k127_3603203_2 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 292.0
TLS2_k127_3606459_0 beta-galactosidase activity K01190,K12308 - 3.2.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 582.0
TLS2_k127_3606459_1 protein-(glutamine-N5) methyltransferase activity K00543,K16130,K18896,K18897,K21515 - 2.1.1.156,2.1.1.157,2.1.1.209,2.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000732 482.0
TLS2_k127_3606459_2 NB-ARC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 514.0
TLS2_k127_3606459_3 NB-ARC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 329.0
TLS2_k127_3606459_4 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 299.0
TLS2_k127_3606459_5 - - - - 0.0000000000000000000000000000000000000000000000002596 183.0
TLS2_k127_3606459_6 Rieske-like [2Fe-2S] domain - - - 0.00000000000000000000000000000001147 132.0
TLS2_k127_3606459_7 HAD-hyrolase-like K07025 - - 0.00000000000000209 78.0
TLS2_k127_3606459_8 - - - - 0.00000000002378 66.0
TLS2_k127_3606459_9 PFAM Spore germination protein-like Gmad2, bacteria - - - 0.0007086 50.0
TLS2_k127_3637659_0 MacB-like periplasmic core domain K02004 - - 0.0 1083.0
TLS2_k127_3637659_1 NYN domain - - - 2.777e-303 942.0
TLS2_k127_3637659_10 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000001483 185.0
TLS2_k127_3637659_11 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000215 171.0
TLS2_k127_3637659_12 COG0346 Lactoylglutathione lyase and related lyases - - - 0.0000000000000000000000000001203 118.0
TLS2_k127_3637659_13 Peptidase M28 - - - 0.0000000000000000000000000007938 128.0
TLS2_k127_3637659_14 Transposase is116 is110 is902 family - - - 0.0000000000000001707 84.0
TLS2_k127_3637659_2 arylsulfatase activity - - - 1.085e-211 666.0
TLS2_k127_3637659_3 transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 571.0
TLS2_k127_3637659_4 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006808 515.0
TLS2_k127_3637659_5 PFAM Cytochrome oxidase assembly K02257,K02259 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005601 367.0
TLS2_k127_3637659_6 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 325.0
TLS2_k127_3637659_7 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 289.0
TLS2_k127_3637659_8 Subtilase family K08651 - 3.4.21.66 0.000000000000000000000000000000000000000000000000000000000000000000000000001059 278.0
TLS2_k127_3637659_9 stress protein (general stress protein 26) - - - 0.000000000000000000000000000000000000000000000000000000000000001623 222.0
TLS2_k127_3650023_0 Pyridoxal-phosphate dependent enzyme - - - 1.851e-241 752.0
TLS2_k127_3650023_1 sh3 domain protein - - - 1.544e-235 772.0
TLS2_k127_3650023_10 - - - - 0.0000000004153 63.0
TLS2_k127_3650023_2 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 502.0
TLS2_k127_3650023_3 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009457 426.0
TLS2_k127_3650023_4 amino acid-binding ACT domain protein K04767 - - 0.00000000000000000000000000000000000000000000000000000005604 199.0
TLS2_k127_3650023_5 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000003245 197.0
TLS2_k127_3650023_6 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000005773 187.0
TLS2_k127_3650023_7 - - - - 0.0000000000000000000000000000000000007974 144.0
TLS2_k127_3650023_8 PFAM Membrane protein of K08972 - - 0.0000000000000005129 81.0
TLS2_k127_3650023_9 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169,K03737 - 1.2.7.1 0.000000000003181 67.0
TLS2_k127_3667401_0 helix_turn_helix, Lux Regulon K03556 - - 0.0 1144.0
TLS2_k127_3667401_1 PFAM glycosyl transferase, family 51 - - - 7.441e-312 972.0
TLS2_k127_3667401_10 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 465.0
TLS2_k127_3667401_11 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007258 458.0
TLS2_k127_3667401_12 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 443.0
TLS2_k127_3667401_13 alcohol dehydrogenase K11440 GO:0003674,GO:0003824,GO:0004022,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 445.0
TLS2_k127_3667401_14 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 420.0
TLS2_k127_3667401_15 Binding-protein-dependent transport system inner membrane component K00759,K02033 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 389.0
TLS2_k127_3667401_16 Oxidoreductase family, NAD-binding Rossmann fold K00010 - 1.1.1.18,1.1.1.369 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 308.0
TLS2_k127_3667401_17 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 292.0
TLS2_k127_3667401_18 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000000000176 218.0
TLS2_k127_3667401_19 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000002743 179.0
TLS2_k127_3667401_2 Belongs to the IlvD Edd family - - - 2.133e-271 848.0
TLS2_k127_3667401_20 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000001242 172.0
TLS2_k127_3667401_21 Phosphoglycerate mutase family K08296 - - 0.00000000000000000000000000000000000000000001744 167.0
TLS2_k127_3667401_22 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000001301 143.0
TLS2_k127_3667401_23 - - - - 0.0000000000000000000006199 99.0
TLS2_k127_3667401_24 YqeY-like protein K09117 - - 0.0000000000000906 76.0
TLS2_k127_3667401_25 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.0000000004851 63.0
TLS2_k127_3667401_26 Domain of unknown function (DUF4386) - - - 0.00000008084 56.0
TLS2_k127_3667401_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.821e-257 807.0
TLS2_k127_3667401_4 PFAM extracellular solute-binding protein family 5 K02035 - - 1.136e-247 781.0
TLS2_k127_3667401_5 Cleaves the N-terminal amino acid of tripeptides K01258 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 550.0
TLS2_k127_3667401_6 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 529.0
TLS2_k127_3667401_7 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007482 511.0
TLS2_k127_3667401_8 aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 466.0
TLS2_k127_3667401_9 NADPH quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 461.0
TLS2_k127_368644_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006403 616.0
TLS2_k127_368644_1 TIGRFAM methylmalonyl-CoA mutase, large subunit K01847,K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 424.0
TLS2_k127_368644_3 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 346.0
TLS2_k127_368644_4 Pfam:DUF59 - - - 0.00000000000000000000000000000000000000000000000000005904 187.0
TLS2_k127_368644_5 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000002451 147.0
TLS2_k127_3695560_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 608.0
TLS2_k127_3695560_1 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 304.0
TLS2_k127_3695560_2 PFAM extracellular solute-binding protein family 1 K17318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 305.0
TLS2_k127_3695560_3 amidohydrolase K07046 - - 0.0000000000000000000000000002739 122.0
TLS2_k127_370171_0 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000606 453.0
TLS2_k127_370171_1 translation release factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 437.0
TLS2_k127_370171_2 Iron-sulfur cluster binding protein K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 399.0
TLS2_k127_370171_3 LUD domain K00782 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 291.0
TLS2_k127_370171_4 lactoylglutathione lyase activity K08234 - - 0.000000006944 59.0
TLS2_k127_3718517_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1160.0
TLS2_k127_3718517_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 545.0
TLS2_k127_3718517_2 cytokinin biosynthetic process K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000007098 213.0
TLS2_k127_3718517_3 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000001085 59.0
TLS2_k127_3739153_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 483.0
TLS2_k127_3739153_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 424.0
TLS2_k127_3739153_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 316.0
TLS2_k127_3739153_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000001641 247.0
TLS2_k127_3739153_4 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000001011 206.0
TLS2_k127_374910_0 Belongs to the glycosyl hydrolase 32 family K03332 - 3.2.1.80 4.735e-217 685.0
TLS2_k127_374910_1 ABC-type dipeptide oligopeptide nickel transport K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 430.0
TLS2_k127_374910_2 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008633 393.0
TLS2_k127_374910_3 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 362.0
TLS2_k127_374910_4 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 347.0
TLS2_k127_374910_5 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000395 83.0
TLS2_k127_3751636_0 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 569.0
TLS2_k127_3751636_1 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005958 474.0
TLS2_k127_3751636_10 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000002978 91.0
TLS2_k127_3751636_11 transcriptional regulator K02483 - - 0.000000007482 63.0
TLS2_k127_3751636_2 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 415.0
TLS2_k127_3751636_3 PFAM transferase hexapeptide repeat containing protein K00661 - 2.3.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 357.0
TLS2_k127_3751636_4 PFAM Rieske 2Fe-2S - - - 0.000000000000000000000000000000000000000000000000003116 186.0
TLS2_k127_3751636_5 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000009241 166.0
TLS2_k127_3751636_6 phosphorelay signal transduction system - - - 0.0000000000000000000000000000007002 130.0
TLS2_k127_3751636_7 Participates in transcription elongation, termination and antitermination K02601,K05785 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000002285 114.0
TLS2_k127_3751636_8 PFAM Transposase DDE domain - - - 0.00000000000000000000000002723 111.0
TLS2_k127_3751636_9 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000009661 114.0
TLS2_k127_3760725_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006176 583.0
TLS2_k127_3760725_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 446.0
TLS2_k127_3760725_2 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 366.0
TLS2_k127_3760725_3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K01921,K03589 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 0.00000000000000000000000000000000000000004089 164.0
TLS2_k127_3760725_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000001408 56.0
TLS2_k127_3776568_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000903 476.0
TLS2_k127_3776568_1 CotH kinase protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009692 465.0
TLS2_k127_3776568_2 DNA-binding transcription factor activity K03710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002461 256.0
TLS2_k127_3776568_3 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001621 244.0
TLS2_k127_3776568_4 Domain of unknown function (DUF4956) - - - 0.0000000000000000000000000000000000000000000000000000000000000004234 226.0
TLS2_k127_3776568_5 COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation - - - 0.00000000000000000000000000000000000000000000001615 181.0
TLS2_k127_3776568_6 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000008196 178.0
TLS2_k127_3776568_7 of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000002183 146.0
TLS2_k127_3776568_8 response to antibiotic K06880 - - 0.00000001281 69.0
TLS2_k127_3776568_9 transcriptional regulator - - - 0.0000002356 53.0
TLS2_k127_3807131_0 alcohol dehydrogenase K00153 - 1.1.1.306 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 411.0
TLS2_k127_3807131_1 Belongs to the HpcH HpaI aldolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 381.0
TLS2_k127_3807131_2 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000003387 261.0
TLS2_k127_3807131_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000008374 227.0
TLS2_k127_3807131_4 Major facilitator Superfamily - - - 0.00000000000000000000000000000001957 141.0
TLS2_k127_3807131_5 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K00663,K19278 - 2.3.1.82 0.00000000000000000000000001886 114.0
TLS2_k127_3807131_6 6-phosphogluconolactonase activity - - - 0.000000007817 60.0
TLS2_k127_3807131_7 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0004605 44.0
TLS2_k127_3829515_0 Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 1.787e-197 633.0
TLS2_k127_3829515_1 -O-antigen K05350,K21000 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 604.0
TLS2_k127_3829515_2 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 400.0
TLS2_k127_3829515_3 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006942 316.0
TLS2_k127_3829515_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 304.0
TLS2_k127_3829909_0 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 491.0
TLS2_k127_3829909_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 488.0
TLS2_k127_3829909_2 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009877 355.0
TLS2_k127_3829909_3 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 344.0
TLS2_k127_3829909_4 Sucrase/ferredoxin-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000132 286.0
TLS2_k127_3829909_5 tetrahydromethanopterin reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006035 265.0
TLS2_k127_3829909_6 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000519 237.0
TLS2_k127_3829909_7 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000001003 207.0
TLS2_k127_3829909_8 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000548 152.0
TLS2_k127_3845754_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007557 306.0
TLS2_k127_3845754_1 Binding-protein-dependent transport system inner membrane component K02026,K17320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002749 271.0
TLS2_k127_3845754_2 binding-protein-dependent transport systems inner membrane component K17319 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002158 264.0
TLS2_k127_3845754_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000001089 185.0
TLS2_k127_3845754_4 ABC transporter substrate-binding protein K17318 - - 0.0000000000000000000000000102 126.0
TLS2_k127_3845754_5 Belongs to the glycosyl hydrolase 2 family - - - 0.0000000001288 66.0
TLS2_k127_3872290_0 DEAD DEAH box helicase domain protein K06877 - - 1.442e-233 752.0
TLS2_k127_3872290_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000006323 130.0
TLS2_k127_3872290_2 Domain of unknown function (DUF4129) - - - 0.0000000000000004865 91.0
TLS2_k127_3899509_0 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 422.0
TLS2_k127_3899509_1 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005393 248.0
TLS2_k127_3899509_2 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000002474 110.0
TLS2_k127_3899509_3 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000127 96.0
TLS2_k127_3899509_4 Protein of unknown function (DUF2442) - - - 0.000000000000000000004939 96.0
TLS2_k127_3899509_5 - - - - 0.00000000000000000001633 98.0
TLS2_k127_3900322_0 Carbohydrate family 9 binding domain-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 418.0
TLS2_k127_3900322_1 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 397.0
TLS2_k127_3900322_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 340.0
TLS2_k127_3900322_3 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000002947 138.0
TLS2_k127_3906278_0 Acetyl xylan esterase (AXE1) K01060 - 3.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 491.0
TLS2_k127_3906278_1 mannonate dehydratase activity K01686 - 4.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 419.0
TLS2_k127_3906278_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 338.0
TLS2_k127_3906278_3 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006058 318.0
TLS2_k127_3906278_4 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 299.0
TLS2_k127_3906278_5 FGGY family of carbohydrate kinases, N-terminal domain K11214 - 2.7.1.14 0.000000000000000000000000000001024 127.0
TLS2_k127_3906435_0 Belongs to the PEP-utilizing enzyme family K01006,K22424 - 2.7.3.13,2.7.9.1 0.0 1081.0
TLS2_k127_3906435_1 Bacterial membrane protein YfhO - - - 6.707e-286 912.0
TLS2_k127_3906435_10 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000002947 228.0
TLS2_k127_3906435_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000009221 204.0
TLS2_k127_3906435_13 - - - - 0.0000000000000000000000000000000000000000000000000001838 193.0
TLS2_k127_3906435_14 BioY family K03523 - - 0.0000000000000000000000000000000656 132.0
TLS2_k127_3906435_15 Transposase DDE domain - - - 0.0000000000000000000000000000001798 126.0
TLS2_k127_3906435_16 Conserved repeat domain - - - 0.00000000000000000000000001379 120.0
TLS2_k127_3906435_17 Dolichyl-phosphate-mannose-protein mannosyltransferase K00728 GO:0000030,GO:0000032,GO:0003674,GO:0003824,GO:0004169,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006056,GO:0006057,GO:0006464,GO:0006486,GO:0006493,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009268,GO:0009405,GO:0009628,GO:0009892,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0010605,GO:0010646,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0019222,GO:0019538,GO:0023051,GO:0030162,GO:0030163,GO:0030447,GO:0031224,GO:0031323,GO:0031324,GO:0031501,GO:0031502,GO:0031505,GO:0031506,GO:0031984,GO:0032268,GO:0032269,GO:0032991,GO:0033554,GO:0034645,GO:0034976,GO:0035268,GO:0035269,GO:0035690,GO:0035966,GO:0035967,GO:0036176,GO:0036177,GO:0036178,GO:0036211,GO:0036244,GO:0036503,GO:0040007,GO:0042175,GO:0042221,GO:0042493,GO:0042546,GO:0042710,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044010,GO:0044011,GO:0044036,GO:0044038,GO:0044085,GO:0044182,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044764,GO:0045229,GO:0045861,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051603,GO:0051703,GO:0051704,GO:0051716,GO:0051788,GO:0060255,GO:0065007,GO:0070085,GO:0070589,GO:0070887,GO:0071214,GO:0071218,GO:0071310,GO:0071467,GO:0071554,GO:0071555,GO:0071704,GO:0071712,GO:0071840,GO:0071852,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0090605,GO:0090609,GO:0097502,GO:0097582,GO:0097586,GO:0098796,GO:0098827,GO:0104004,GO:1900101,GO:1901135,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1902494,GO:1905897,GO:1990234 2.4.1.109 0.0008247 52.0
TLS2_k127_3906435_2 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 5.75e-216 690.0
TLS2_k127_3906435_3 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K09065 - 2.1.3.9 3.363e-195 616.0
TLS2_k127_3906435_4 Histidine kinase K00936,K02030,K10441,K13924,K20962 - 2.1.1.80,2.7.13.3,3.1.1.61,3.1.4.52,3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 537.0
TLS2_k127_3906435_5 SPFH domain-Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 502.0
TLS2_k127_3906435_6 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 414.0
TLS2_k127_3906435_7 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 398.0
TLS2_k127_3906435_8 PFAM oxidoreductase, molybdopterin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 365.0
TLS2_k127_3906435_9 PFAM response regulator receiver K22010 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009115 315.0
TLS2_k127_3907195_0 PhoQ Sensor - - - 1.073e-195 643.0
TLS2_k127_3907195_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 606.0
TLS2_k127_3907195_10 conserved small protein - - - 0.000000000000000002415 86.0
TLS2_k127_3907195_11 Sulphur transport K07112 - - 0.000000000000000003064 88.0
TLS2_k127_3907195_12 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.000000000002569 69.0
TLS2_k127_3907195_13 - - - - 0.0000000000339 65.0
TLS2_k127_3907195_14 Xylose isomerase - - - 0.0000000003904 71.0
TLS2_k127_3907195_15 haloacid dehalogenase-like hydrolase K07025 - - 0.00002829 53.0
TLS2_k127_3907195_2 Histidine kinase-like ATPases K01768,K02488,K17763 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65,4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 490.0
TLS2_k127_3907195_3 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007258 458.0
TLS2_k127_3907195_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 316.0
TLS2_k127_3907195_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 310.0
TLS2_k127_3907195_6 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 301.0
TLS2_k127_3907195_7 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000001028 184.0
TLS2_k127_3907195_8 - - - - 0.0000000000000000000000000000000000000000000000001852 180.0
TLS2_k127_3907195_9 Protein of unknown function (DUF2568) - - - 0.000000000000000000000000000000004241 131.0
TLS2_k127_3910602_0 sh3 domain protein - - - 0.0 1307.0
TLS2_k127_3910602_1 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 5.167e-290 903.0
TLS2_k127_3910602_10 PFAM zinc finger, SWIM domain protein - - - 0.0000000000000000000000000004759 115.0
TLS2_k127_3910602_11 isomerase activity K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000007529 113.0
TLS2_k127_3910602_12 Bacterial SH3 domain - - - 0.0002282 54.0
TLS2_k127_3910602_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.533e-227 713.0
TLS2_k127_3910602_3 sh3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 605.0
TLS2_k127_3910602_4 Peptidase M16 domain protein K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 497.0
TLS2_k127_3910602_5 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 433.0
TLS2_k127_3910602_6 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 401.0
TLS2_k127_3910602_7 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009707 258.0
TLS2_k127_3910602_9 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000008839 144.0
TLS2_k127_3919299_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 3.091e-317 979.0
TLS2_k127_3919299_1 PFAM cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 322.0
TLS2_k127_3919299_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002632 283.0
TLS2_k127_3919299_3 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006096 271.0
TLS2_k127_3919299_4 Large extracellular alpha-helical protein K13735 - - 0.0000000000000000000000000009635 123.0
TLS2_k127_3923225_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.218e-268 832.0
TLS2_k127_3923225_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.853e-261 810.0
TLS2_k127_3923225_10 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000005013 83.0
TLS2_k127_3923225_2 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 606.0
TLS2_k127_3923225_3 PFAM RNA binding S1 domain protein K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 549.0
TLS2_k127_3923225_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000592 400.0
TLS2_k127_3923225_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.000000000000000000000000000000000000000000000000000000000287 206.0
TLS2_k127_3923225_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000002657 179.0
TLS2_k127_3923225_7 endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000001507 151.0
TLS2_k127_3923225_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000003432 144.0
TLS2_k127_3923225_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000006645 117.0
TLS2_k127_39362_0 phosphoenolpyruvate synthase K01007 - 2.7.9.2 0.0 1305.0
TLS2_k127_39362_1 PFAM VWA containing CoxE family protein K07161 - - 6.892e-210 660.0
TLS2_k127_39362_2 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 507.0
TLS2_k127_39362_3 succinyl-diaminopimelate desuccinylase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 441.0
TLS2_k127_39362_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 331.0
TLS2_k127_39362_5 haloacid dehalogenase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006726 311.0
TLS2_k127_39362_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000006626 178.0
TLS2_k127_39362_7 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000005881 166.0
TLS2_k127_39362_8 - - - - 0.00000000000000000000000000000000003089 141.0
TLS2_k127_39362_9 Putative bacterial sensory transduction regulator - - - 0.00000000000007507 79.0
TLS2_k127_3940543_0 PFAM PSP1 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 482.0
TLS2_k127_3940543_1 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007426 360.0
TLS2_k127_3940543_2 NUDIX domain K08310 - 3.6.1.67 0.000000000000000000000000149 110.0
TLS2_k127_3947922_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009891 509.0
TLS2_k127_3947922_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 494.0
TLS2_k127_3947922_2 cobalamin synthesis CobW domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 329.0
TLS2_k127_3947922_3 Zinc-uptake complex component A periplasmic K09818 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000218 259.0
TLS2_k127_3947922_4 acetyltransferase K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000009528 224.0
TLS2_k127_3947922_5 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000001085 193.0
TLS2_k127_3947922_6 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000001563 53.0
TLS2_k127_3950600_0 Elongator protein 3, MiaB family, Radical SAM - - - 5.847e-272 842.0
TLS2_k127_3950600_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 310.0
TLS2_k127_3950600_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 305.0
TLS2_k127_3950600_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 295.0
TLS2_k127_3950600_5 integral membrane protein K02221 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000001265 119.0
TLS2_k127_3982470_0 Altronate hydrolase K01685,K01708 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0008789,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046392,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575 4.2.1.42,4.2.1.7 5e-323 1013.0
TLS2_k127_3982470_1 transport system K01992 - - 2.473e-270 862.0
TLS2_k127_3982470_10 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 391.0
TLS2_k127_3982470_11 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573,K03183,K07003 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 2.1.1.163,2.1.1.201,2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 384.0
TLS2_k127_3982470_12 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 366.0
TLS2_k127_3982470_13 Nucleoside H+ symporter K05820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 362.0
TLS2_k127_3982470_14 PFAM inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 344.0
TLS2_k127_3982470_15 NAD dependent epimerase/dehydratase family K07124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 357.0
TLS2_k127_3982470_16 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 341.0
TLS2_k127_3982470_17 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007524 339.0
TLS2_k127_3982470_18 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008952 353.0
TLS2_k127_3982470_19 Domain of unknown function (DUF5060) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 346.0
TLS2_k127_3982470_2 FAD dependent oxidoreductase - - - 3.105e-247 773.0
TLS2_k127_3982470_20 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 329.0
TLS2_k127_3982470_21 transcriptional regulator domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 299.0
TLS2_k127_3982470_22 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 306.0
TLS2_k127_3982470_23 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 301.0
TLS2_k127_3982470_24 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 302.0
TLS2_k127_3982470_25 SMP-30 Gluconolaconase K14274 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004364 282.0
TLS2_k127_3982470_26 GNAT acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005496 274.0
TLS2_k127_3982470_27 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002046 271.0
TLS2_k127_3982470_28 ADP-glyceromanno-heptose 6-epimerase activity K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000001991 261.0
TLS2_k127_3982470_29 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004674 258.0
TLS2_k127_3982470_3 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 578.0
TLS2_k127_3982470_30 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004536 251.0
TLS2_k127_3982470_31 PFAM sigma-70 region 2 domain protein K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002194 246.0
TLS2_k127_3982470_32 Phospholipase/Carboxylesterase K06999,K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009733 243.0
TLS2_k127_3982470_33 sigma-70 region 2 domain protein K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000002926 236.0
TLS2_k127_3982470_34 PFAM metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000008198 236.0
TLS2_k127_3982470_35 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000001161 242.0
TLS2_k127_3982470_36 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000005075 231.0
TLS2_k127_3982470_37 HD superfamily K07023 - - 0.0000000000000000000000000000000000000000000000000000000000007198 217.0
TLS2_k127_3982470_38 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000000000000003914 223.0
TLS2_k127_3982470_4 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 573.0
TLS2_k127_3982470_40 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000004622 194.0
TLS2_k127_3982470_41 SpoU rRNA Methylase family - - - 0.000000000000000000000000000000000000000000000000007614 188.0
TLS2_k127_3982470_42 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000002794 186.0
TLS2_k127_3982470_43 Protease prsW family - - - 0.00000000000000000000000000000000000000000000006286 181.0
TLS2_k127_3982470_44 Domain of unknown function (DUF4269) - - - 0.00000000000000000000000000000000000000000002342 168.0
TLS2_k127_3982470_45 Bacterial transferase hexapeptide repeat K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000007437 154.0
TLS2_k127_3982470_46 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000003766 142.0
TLS2_k127_3982470_47 dihydroorotate dehydrogenase activity K17828 - 1.3.1.14 0.0000000000000000000000000000000001162 143.0
TLS2_k127_3982470_48 Protein of unknown function (DUF3604) - - - 0.0000000000000000000000000003047 132.0
TLS2_k127_3982470_49 - - - - 0.0000000000000000000000000009502 116.0
TLS2_k127_3982470_5 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007621 524.0
TLS2_k127_3982470_50 GNAT acetyltransferase K06976 - - 0.0000000000000000000001472 107.0
TLS2_k127_3982470_51 Domain of unknown function (DUF4976) - - - 0.0000000000000000000004509 102.0
TLS2_k127_3982470_53 Domain of unknown function (DUF4340) - - - 0.000000000000001313 89.0
TLS2_k127_3982470_54 glyoxalase - - - 0.00009075 51.0
TLS2_k127_3982470_55 COG0457 FOG TPR repeat - - - 0.0007623 51.0
TLS2_k127_3982470_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 528.0
TLS2_k127_3982470_7 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 477.0
TLS2_k127_3982470_8 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 456.0
TLS2_k127_3982470_9 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 445.0
TLS2_k127_3982483_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 595.0
TLS2_k127_3982483_1 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 561.0
TLS2_k127_3982483_2 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007552 387.0
TLS2_k127_3982483_3 Binding-protein-dependent transport system inner membrane component K02026,K10242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 364.0
TLS2_k127_3982483_4 PFAM Binding-protein-dependent transport system inner membrane component K02025,K10241 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 289.0
TLS2_k127_3982483_5 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009845 252.0
TLS2_k127_3982483_6 Trypsin-like serine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000001814 245.0
TLS2_k127_3982483_7 Belongs to the DapA family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000002334 164.0
TLS2_k127_3982483_8 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000001901 86.0
TLS2_k127_3982483_9 Beta-lactamase superfamily domain - - - 0.000000000000001096 87.0
TLS2_k127_4040142_0 radical SAM domain protein - - - 3.643e-251 780.0
TLS2_k127_4040142_1 homoserine kinase activity K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 344.0
TLS2_k127_4040142_2 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000005826 148.0
TLS2_k127_4040142_5 Male sterility protein K21793 - - 0.00001821 46.0
TLS2_k127_4054351_0 4Fe-4S double cluster binding domain K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 538.0
TLS2_k127_4054351_1 PFAM major facilitator superfamily MFS_1 K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007782 375.0
TLS2_k127_4054351_2 Catalase K07217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 313.0
TLS2_k127_4054351_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000006133 188.0
TLS2_k127_4054351_4 COG3546 Mn-containing catalase K07217 - - 0.000000000000000008376 83.0
TLS2_k127_4062989_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0 1240.0
TLS2_k127_4062989_1 3-hydroxyacyl-CoA dehydrogenase domain protein K07516 - 1.1.1.35 1.758e-273 866.0
TLS2_k127_4062989_10 peptidoglycan receptor activity - - - 0.0007134 52.0
TLS2_k127_4062989_2 PFAM peptidase M3A and M3B, thimet oligopeptidase F K08602 - - 1.969e-239 754.0
TLS2_k127_4062989_3 Peptidase family C25 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 506.0
TLS2_k127_4062989_4 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 411.0
TLS2_k127_4062989_5 N-acetyltransferase K00675 - 2.3.1.118 0.000000000000000000000000000000000000000000000000000001494 203.0
TLS2_k127_4062989_6 Dimerisation domain of Zinc Transporter - - - 0.000000000000000000000000000000000000000000000000002109 199.0
TLS2_k127_4062989_7 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000006727 177.0
TLS2_k127_4062989_8 heme binding K21472 - - 0.000000000000000000000000000000000000000000002953 184.0
TLS2_k127_4062989_9 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000003439 147.0
TLS2_k127_4066564_0 Alpha-L-arabinofuranosidase C-terminus K01209 - 3.2.1.55 3.382e-224 706.0
TLS2_k127_4066564_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 6.216e-202 645.0
TLS2_k127_4066564_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K05299 - 1.17.1.10,1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007215 416.0
TLS2_k127_4066564_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005235 396.0
TLS2_k127_4066564_4 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004773 385.0
TLS2_k127_4066564_5 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 381.0
TLS2_k127_4066564_6 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 327.0
TLS2_k127_4066564_7 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 302.0
TLS2_k127_4066564_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000003027 64.0
TLS2_k127_4075350_0 TIGRFAM drug resistance transporter, Bcr CflA subfamily K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 470.0
TLS2_k127_4075350_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 364.0
TLS2_k127_4075350_10 Glycosyl hydrolases family 25 - - - 0.00000000000003368 84.0
TLS2_k127_4075350_11 PFAM extracellular solute-binding protein family 1 K17329 - - 0.0001584 54.0
TLS2_k127_4075350_2 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 312.0
TLS2_k127_4075350_3 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000001073 257.0
TLS2_k127_4075350_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000001091 197.0
TLS2_k127_4075350_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000002083 173.0
TLS2_k127_4075350_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000003418 160.0
TLS2_k127_4075350_7 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000162 148.0
TLS2_k127_4075350_8 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000001131 135.0
TLS2_k127_4075350_9 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000000000000000001319 87.0
TLS2_k127_4077543_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 447.0
TLS2_k127_4077543_10 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000001184 156.0
TLS2_k127_4077543_11 mRNA catabolic process - - - 0.0000000000000000000000000000000002427 142.0
TLS2_k127_4077543_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 292.0
TLS2_k127_4077543_3 Polysaccharide pyruvyl transferase K16710 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002383 293.0
TLS2_k127_4077543_4 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008452 280.0
TLS2_k127_4077543_5 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001402 284.0
TLS2_k127_4077543_6 Protein of unknown function (DUF998) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001551 259.0
TLS2_k127_4077543_7 Macrocin-O-methyltransferase (TylF) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000003853 254.0
TLS2_k127_4077543_8 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000008027 218.0
TLS2_k127_4077543_9 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000005352 183.0
TLS2_k127_4078447_0 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 416.0
TLS2_k127_4078447_2 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001643 252.0
TLS2_k127_4090918_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K21417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 529.0
TLS2_k127_4090918_1 PFAM Arsenical pump membrane protein K03893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 492.0
TLS2_k127_4090918_10 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000003301 200.0
TLS2_k127_4090918_11 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000001336 178.0
TLS2_k127_4090918_12 dehydrogenases and related proteins - - - 0.000000000000000000000000000000256 138.0
TLS2_k127_4090918_13 Bacterial extracellular solute-binding protein K02027 - - 0.00004989 52.0
TLS2_k127_4090918_2 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 478.0
TLS2_k127_4090918_3 PFAM dehydrogenase E1 component K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 467.0
TLS2_k127_4090918_4 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 410.0
TLS2_k127_4090918_5 Catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 403.0
TLS2_k127_4090918_6 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01639,K01714 - 4.1.3.3,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 289.0
TLS2_k127_4090918_7 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000002775 220.0
TLS2_k127_4090918_8 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000006598 208.0
TLS2_k127_4090918_9 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000001063 202.0
TLS2_k127_4097169_0 Lamin Tail Domain - - - 2.456e-229 737.0
TLS2_k127_4097169_1 X-Pro dipeptidyl-peptidase domain protein K06978 - - 6.116e-197 631.0
TLS2_k127_4104257_0 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009693 316.0
TLS2_k127_4104257_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 287.0
TLS2_k127_4117023_0 PFAM Glycosyl transferase family 2 K00694 - 2.4.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 540.0
TLS2_k127_4117023_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 420.0
TLS2_k127_4117206_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 2.718e-233 724.0
TLS2_k127_4117206_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.221e-214 674.0
TLS2_k127_4117206_10 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000002999 215.0
TLS2_k127_4117206_11 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000000000006517 213.0
TLS2_k127_4117206_12 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000001129 202.0
TLS2_k127_4117206_13 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000115 192.0
TLS2_k127_4117206_14 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000005965 175.0
TLS2_k127_4117206_15 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000003911 169.0
TLS2_k127_4117206_16 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000001492 166.0
TLS2_k127_4117206_17 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000481 153.0
TLS2_k127_4117206_18 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000004656 148.0
TLS2_k127_4117206_19 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000000000000000000001523 145.0
TLS2_k127_4117206_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 459.0
TLS2_k127_4117206_20 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000007517 134.0
TLS2_k127_4117206_21 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000002098 97.0
TLS2_k127_4117206_22 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000004256 80.0
TLS2_k127_4117206_23 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000004418 81.0
TLS2_k127_4117206_3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 351.0
TLS2_k127_4117206_4 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 312.0
TLS2_k127_4117206_5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 306.0
TLS2_k127_4117206_6 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001637 269.0
TLS2_k127_4117206_7 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008516 267.0
TLS2_k127_4117206_8 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000003171 242.0
TLS2_k127_4117206_9 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000003341 220.0
TLS2_k127_412342_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006,K01007 - 2.7.9.1,2.7.9.2 6.216e-244 766.0
TLS2_k127_412342_1 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 1.472e-236 738.0
TLS2_k127_412342_2 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000227 255.0
TLS2_k127_412342_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002853 235.0
TLS2_k127_412342_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000006561 217.0
TLS2_k127_412342_5 O-Antigen ligase - - - 0.000000000000000000000000000000000000000000000000000000009162 202.0
TLS2_k127_412342_6 Putative zincin peptidase - - - 0.000000000000000000000000000000000000000004513 162.0
TLS2_k127_4128613_0 PFAM peptidase M1, membrane alanine aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 557.0
TLS2_k127_4128613_1 PFAM ABC transporter related K02028,K09972 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 389.0
TLS2_k127_4128613_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009556 349.0
TLS2_k127_4128613_3 PFAM Phosphoglycerate mutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007342 276.0
TLS2_k127_4128613_4 Protein of unknown function (DUF3090) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001611 267.0
TLS2_k127_4128613_5 Double zinc ribbon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006199 245.0
TLS2_k127_4128613_6 phosphatidylinositol kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007872 243.0
TLS2_k127_4128613_7 Aminoacyl-tRNA editing domain - - - 0.0000000000000000000000000000000000000000000000000001409 191.0
TLS2_k127_4128613_8 - - - - 0.0009338 49.0
TLS2_k127_4139494_0 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 415.0
TLS2_k127_4139494_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 357.0
TLS2_k127_4139494_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 314.0
TLS2_k127_4139494_3 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001083 261.0
TLS2_k127_4139494_4 Acetyltransferase (GNAT) domain - - - 0.000000000379 63.0
TLS2_k127_4171839_0 carbon phosphorus lyase activity K06163 - 4.7.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 456.0
TLS2_k127_4171839_1 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity K06164 - 2.7.8.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 454.0
TLS2_k127_4171839_2 organic phosphonate catabolic process K05781,K06163 GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0044237,GO:0046434,GO:0071704,GO:1901575,GO:1902494,GO:1904176 4.7.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 286.0
TLS2_k127_4171839_3 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity K06165 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0042802,GO:0044237,GO:0046434,GO:0061694,GO:0061695,GO:0071704,GO:1901575,GO:1902494,GO:1904176,GO:1990234 2.7.8.37 0.000000000000000000000000000000000000000000000001846 181.0
TLS2_k127_4171839_4 Phosphonate C-P lyase system protein PhnG K06166 - 2.7.8.37 0.000000000000000000000000000000009536 133.0
TLS2_k127_417367_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00124,K05587,K18331 - 1.12.1.3,1.6.5.3 6.01e-257 803.0
TLS2_k127_417367_1 PFAM nickel-dependent hydrogenase, large subunit K00436,K14126 - 1.12.1.2,1.8.98.5 5.609e-235 734.0
TLS2_k127_417367_2 4fe-4S ferredoxin, iron-sulfur binding domain protein K05588 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 427.0
TLS2_k127_417367_3 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334,K05586 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000948 270.0
TLS2_k127_417367_4 PFAM NADH ubiquinone oxidoreductase, 20 K18007 - 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000002849 257.0
TLS2_k127_417367_5 PFAM electron transport protein SCO1 SenC K07152 - - 0.000000000000000000000000000003966 124.0
TLS2_k127_417367_6 Domain of unknown function (DUF4157) - - - 0.000000000000000006114 98.0
TLS2_k127_417367_7 TIGRFAM hydrogenase maturation protease - - - 0.0000000000000007971 84.0
TLS2_k127_4178982_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 1.102e-232 729.0
TLS2_k127_4178982_1 Alpha-L-fucosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 559.0
TLS2_k127_4178982_10 Belongs to the 'phage' integrase family K04763 - - 0.00003012 50.0
TLS2_k127_4178982_11 Phage integrase, N-terminal SAM-like domain - - - 0.0003462 48.0
TLS2_k127_4178982_2 Pfam Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007984 384.0
TLS2_k127_4178982_3 SMART helix-turn-helix domain protein K18831 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003941 325.0
TLS2_k127_4178982_4 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000000000000000001787 225.0
TLS2_k127_4178982_5 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000007153 168.0
TLS2_k127_4178982_6 oxidoreductase - - - 0.00000000000000000000000000000000000000001113 167.0
TLS2_k127_4178982_7 TIGRFAM primosome, DnaD subunit - - - 0.0000000000000000000000000000005428 123.0
TLS2_k127_4178982_8 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system K19166 - - 0.00000000000089 68.0
TLS2_k127_4178982_9 protein conserved in bacteria K19166 - - 0.00000000000136 70.0
TLS2_k127_4189612_0 PFAM ABC transporter transmembrane region - - - 2.152e-266 833.0
TLS2_k127_4189612_1 PFAM sodium hydrogen exchanger - - - 1.307e-248 787.0
TLS2_k127_4189612_2 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 465.0
TLS2_k127_4189612_4 - - - - 0.000002602 49.0
TLS2_k127_4193936_0 PFAM Dynamin family protein - - - 8.886e-225 712.0
TLS2_k127_4193936_1 Belongs to the GPI family K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 415.0
TLS2_k127_4193936_2 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000001352 216.0
TLS2_k127_4193936_3 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000001225 201.0
TLS2_k127_4201671_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1305.0
TLS2_k127_4201671_1 Pyridoxal-dependent decarboxylase conserved domain - - - 3.725e-199 631.0
TLS2_k127_4201671_10 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000009672 221.0
TLS2_k127_4201671_11 sh3 domain protein K12132,K15539 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000009652 212.0
TLS2_k127_4201671_12 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000000000000001192 202.0
TLS2_k127_4201671_13 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000005134 137.0
TLS2_k127_4201671_14 Histidine kinase - - - 0.00000000000000000000004018 102.0
TLS2_k127_4201671_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 601.0
TLS2_k127_4201671_4 short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 584.0
TLS2_k127_4201671_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 574.0
TLS2_k127_4201671_6 PFAM AAA-4 family protein K02444,K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 530.0
TLS2_k127_4201671_7 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 467.0
TLS2_k127_4201671_8 sh3 domain protein K12132,K15539 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 359.0
TLS2_k127_4201671_9 sh3 domain protein K12132,K15539 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 329.0
TLS2_k127_4248204_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 3.576e-241 762.0
TLS2_k127_4248204_1 Belongs to the ABC transporter superfamily K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 598.0
TLS2_k127_4248204_2 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 580.0
TLS2_k127_4248204_3 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 542.0
TLS2_k127_4248204_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 512.0
TLS2_k127_4248204_5 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 510.0
TLS2_k127_4248204_6 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005492 431.0
TLS2_k127_4248204_7 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000149 266.0
TLS2_k127_4265008_0 FAD linked oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 582.0
TLS2_k127_4265008_1 Oxidoreductase molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 470.0
TLS2_k127_4265008_2 PFAM Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000079 382.0
TLS2_k127_4265008_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000003615 72.0
TLS2_k127_4272445_1 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 563.0
TLS2_k127_4272445_10 ABC-type sugar transport system, permease component K10238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 341.0
TLS2_k127_4272445_11 cellular response to dsDNA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 334.0
TLS2_k127_4272445_12 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 334.0
TLS2_k127_4272445_13 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 317.0
TLS2_k127_4272445_14 Belongs to the glycosyltransferase 26 family K05946 - 2.4.1.187 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 310.0
TLS2_k127_4272445_15 Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis K03816 - 2.4.2.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 289.0
TLS2_k127_4272445_16 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001289 258.0
TLS2_k127_4272445_17 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000005575 260.0
TLS2_k127_4272445_18 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000000000000000000000000000000001761 207.0
TLS2_k127_4272445_19 sh3 domain protein K01448,K04771,K08884 - 2.7.11.1,3.4.21.107,3.5.1.28 0.0000000000000000000000000000000000000000000000002351 198.0
TLS2_k127_4272445_2 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 522.0
TLS2_k127_4272445_20 Protein of unknown function (DUF3037) - - - 0.000000000000000000000000000000000000002466 150.0
TLS2_k127_4272445_21 Thioesterase superfamily - - - 0.00000000000000000000000000000000000005414 148.0
TLS2_k127_4272445_22 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000001424 126.0
TLS2_k127_4272445_24 - - - - 0.00000000000002065 84.0
TLS2_k127_4272445_3 Bacterial extracellular solute-binding protein K02027,K10236 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 461.0
TLS2_k127_4272445_4 nitrite transmembrane transporter activity K08191,K08369 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004456 428.0
TLS2_k127_4272445_5 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 410.0
TLS2_k127_4272445_6 DNA methylase K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 379.0
TLS2_k127_4272445_7 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206,K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007937 361.0
TLS2_k127_4272445_8 transferase activity, transferring hexosyl groups K18101 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 360.0
TLS2_k127_4272445_9 Binding-protein-dependent transport system inner membrane component K10237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 345.0
TLS2_k127_428438_0 COG1312 D-mannonate dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 348.0
TLS2_k127_428438_1 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000000000000000000000000002462 166.0
TLS2_k127_428438_2 Alpha beta hydrolase K15357 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0044237,GO:0044248 3.5.1.106 0.000000000000000000000000000000000000000002314 162.0
TLS2_k127_428438_3 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.000000000000000000000000000000000001032 149.0
TLS2_k127_428438_4 belongs to the sigma-70 factor family - - - 0.000000000000000000000000000003397 130.0
TLS2_k127_428438_5 chromosome segregation - - - 0.0000000000000000000002408 102.0
TLS2_k127_428438_6 toxin-antitoxin system toxin component, PIN family - - - 0.00003017 46.0
TLS2_k127_4324657_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 461.0
TLS2_k127_4324657_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008253 357.0
TLS2_k127_4324657_2 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 325.0
TLS2_k127_4324657_3 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007909 316.0
TLS2_k127_4346411_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 6.295e-256 799.0
TLS2_k127_4346411_1 Peptidase S9, prolyl oligopeptidase active site domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 496.0
TLS2_k127_4346411_2 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 379.0
TLS2_k127_4346411_3 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 310.0
TLS2_k127_4346411_4 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002175 268.0
TLS2_k127_4346411_5 homoserine kinase type II (protein kinase fold) - - - 0.0000000000000000000000000000000000000000000000000003595 200.0
TLS2_k127_4346411_6 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000002289 175.0
TLS2_k127_4346411_7 SnoaL-like domain - - - 0.00000000000000000000000000000000001328 140.0
TLS2_k127_4346991_0 Tetratricopeptide TPR_2 repeat protein - - - 5.397e-217 698.0
TLS2_k127_43527_0 Pfam:KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 442.0
TLS2_k127_43527_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004942 389.0
TLS2_k127_43527_2 dioxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008539 298.0
TLS2_k127_43527_3 glycerophosphodiester transmembrane transport K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000004777 235.0
TLS2_k127_43527_4 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814 - - 0.000000000000000000000000000000000000000000000000000000000009439 219.0
TLS2_k127_43527_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000008923 196.0
TLS2_k127_43527_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000001266 139.0
TLS2_k127_43527_7 carbohydrate transport K02027 - - 0.000000000000000000000000004023 126.0
TLS2_k127_43527_8 AAA domain K07132 - 3.6.1.3 0.0000000000001393 70.0
TLS2_k127_43527_9 KaiB domain K08481 - - 0.0000000000003896 73.0
TLS2_k127_4369805_0 LPXTG-motif cell wall anchor domain - - - 0.0 1127.0
TLS2_k127_4369805_1 Alpha amylase, catalytic domain - - - 3.286e-208 668.0
TLS2_k127_4369805_10 binding-protein-dependent transport systems inner membrane component K02026,K10242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001401 275.0
TLS2_k127_4369805_11 Acetyl xylan esterase (AXE1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001898 269.0
TLS2_k127_4369805_12 PFAM Uncharacterised BCR, COG1649 K11931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004088 259.0
TLS2_k127_4369805_13 uridine kinase K00876 - 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000006438 226.0
TLS2_k127_4369805_14 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000001531 224.0
TLS2_k127_4369805_15 methylglyoxal synthase activity K01734 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 0.0000000000000000000000000000000000000000000000000000000000002638 217.0
TLS2_k127_4369805_16 Catalyzes the dehydration of D-mannonate K01686 - 4.2.1.8 0.000000000000000000000000000000000000000000000000000000000000835 219.0
TLS2_k127_4369805_17 cephalosporin-C deacetylase activity K01060 - 3.1.1.41 0.00000000000000000000000000000000000000000005191 172.0
TLS2_k127_4369805_18 Major facilitator superfamily - - - 0.00000000000000000000000000000000000007625 158.0
TLS2_k127_4369805_19 - - - - 0.000000000000000000000000000000002815 132.0
TLS2_k127_4369805_2 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 587.0
TLS2_k127_4369805_20 epimerase - - - 0.00000000000000000000000000000001966 139.0
TLS2_k127_4369805_21 Rieske-like [2Fe-2S] domain - - - 0.0000000000000000000000000001605 119.0
TLS2_k127_4369805_22 Mo-molybdopterin cofactor metabolic process K03636 - - 0.00000000000000000000000769 104.0
TLS2_k127_4369805_23 - - - - 0.0000000000000000000005859 103.0
TLS2_k127_4369805_24 solute-binding protein K02027 - - 0.000000000000000000005895 106.0
TLS2_k127_4369805_25 pyridoxamine 5'-phosphate K07005 - - 0.000000000000000003683 93.0
TLS2_k127_4369805_26 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000005324 98.0
TLS2_k127_4369805_27 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.00000000000004698 74.0
TLS2_k127_4369805_28 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.000002438 49.0
TLS2_k127_4369805_3 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 524.0
TLS2_k127_4369805_4 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 479.0
TLS2_k127_4369805_5 Cys/Met metabolism PLP-dependent enzyme K19715 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576 2.6.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 472.0
TLS2_k127_4369805_6 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000957 426.0
TLS2_k127_4369805_7 L-seryl-tRNASec selenium transferase activity K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 393.0
TLS2_k127_4369805_8 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 313.0
TLS2_k127_4369805_9 PFAM Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001008 285.0
TLS2_k127_4374435_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000195 247.0
TLS2_k127_4374435_1 Domain of unknown function (DUF4281) - - - 0.000000000000000000000000000000000001525 143.0
TLS2_k127_4374435_2 Methyltransferase type 11 - - - 0.0000000000000000000000000004069 116.0
TLS2_k127_4374435_3 transcriptional regulator - - - 0.00000000000000000000000006011 115.0
TLS2_k127_4390100_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 449.0
TLS2_k127_4390100_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 389.0
TLS2_k127_4390100_2 D-aminopeptidase K16203 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004068 282.0
TLS2_k127_4390100_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001962 272.0
TLS2_k127_4390100_4 Malate/L-lactate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000197 273.0
TLS2_k127_4390100_5 creatinase K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000942 159.0
TLS2_k127_4390100_6 - - - - 0.000000000000000000000000009989 113.0
TLS2_k127_4390967_0 carbohydrate transport K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 356.0
TLS2_k127_4390967_1 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 353.0
TLS2_k127_4390967_10 Extracellular solute-binding protein - - - 0.00000000000000000000001401 115.0
TLS2_k127_4390967_2 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 319.0
TLS2_k127_4390967_3 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 298.0
TLS2_k127_4390967_4 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 284.0
TLS2_k127_4390967_5 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 287.0
TLS2_k127_4390967_6 COG0395 ABC-type sugar transport system, permease component K02026,K10242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007182 276.0
TLS2_k127_4390967_7 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000005574 226.0
TLS2_k127_4390967_8 PhoQ Sensor K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000003154 173.0
TLS2_k127_4390967_9 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000002096 152.0
TLS2_k127_4412455_0 peptidase M20 - - - 1.587e-197 625.0
TLS2_k127_4412455_1 PFAM Mandelate racemase muconate lactonizing enzyme K01683,K01684,K08323 GO:0000287,GO:0003674,GO:0005488,GO:0043167,GO:0043169,GO:0046872 4.2.1.5,4.2.1.6,4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 535.0
TLS2_k127_4412455_10 - - - - 0.0000000000000000000002719 108.0
TLS2_k127_4412455_11 - - - - 0.000000000000000000008079 107.0
TLS2_k127_4412455_12 NlpC/P60 family K19223,K19224,K21471 - - 0.000000000000003023 86.0
TLS2_k127_4412455_13 sh3 domain protein - - - 0.000000000000009741 88.0
TLS2_k127_4412455_14 sh3 domain protein - - - 0.00000000005241 75.0
TLS2_k127_4412455_15 Pyrrolo-quinoline quinone - - - 0.00000006708 65.0
TLS2_k127_4412455_16 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0000009269 61.0
TLS2_k127_4412455_17 Glyco_18 K06306 - - 0.000004938 59.0
TLS2_k127_4412455_18 family 18 - - - 0.00003407 57.0
TLS2_k127_4412455_19 COG COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0001698 50.0
TLS2_k127_4412455_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 354.0
TLS2_k127_4412455_3 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 354.0
TLS2_k127_4412455_4 MacB-like periplasmic core domain K02004,K05685 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 312.0
TLS2_k127_4412455_5 Two component transcriptional regulator, winged helix family K07658 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006476 273.0
TLS2_k127_4412455_6 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005448 274.0
TLS2_k127_4412455_7 histidine kinase A domain protein K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000003362 256.0
TLS2_k127_4412455_8 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000002468 162.0
TLS2_k127_4412455_9 PFAM secretion protein HlyD family protein - - - 0.000000000000000000000000000001673 138.0
TLS2_k127_4441072_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 4.548e-206 664.0
TLS2_k127_4441072_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 531.0
TLS2_k127_4441072_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006334 452.0
TLS2_k127_4441072_3 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 311.0
TLS2_k127_4465825_0 Pyridine nucleotide-disulphide oxidoreductase dimerisation region K00382 - 1.8.1.4 4.21e-233 728.0
TLS2_k127_4465825_1 PFAM DSBA oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 486.0
TLS2_k127_4465825_10 Von Willebrand factor K07114 - - 0.00001851 59.0
TLS2_k127_4465825_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 449.0
TLS2_k127_4465825_3 NAD(P)H-binding K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 417.0
TLS2_k127_4465825_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 331.0
TLS2_k127_4465825_5 DNA recombination - - - 0.0000000000000000000000000000000000000000000000000006664 210.0
TLS2_k127_4465825_6 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000006248 177.0
TLS2_k127_4465825_7 Catalytic domain of components of various dehydrogenase complexes K00658 - 2.3.1.61 0.000000000000000000000001225 104.0
TLS2_k127_4465825_8 - - - - 0.00000000000005026 72.0
TLS2_k127_4465825_9 - - - - 0.000007628 50.0
TLS2_k127_447430_0 Aminotransferase class-III - - - 3.309e-204 646.0
TLS2_k127_447430_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000002604 114.0
TLS2_k127_4475258_0 PFAM Cytochrome C assembly protein K02198 - - 3.114e-316 979.0
TLS2_k127_4475258_1 Protein of unknown function (DUF1501) - - - 4.825e-206 651.0
TLS2_k127_4475258_10 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001862 289.0
TLS2_k127_4475258_11 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.00000000000000000000000000000000000000000000000000000000000000000000581 239.0
TLS2_k127_4475258_12 WG containing repeat - - - 0.0000000000000000000000000000000000000000000000000002119 209.0
TLS2_k127_4475258_13 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000001971 187.0
TLS2_k127_4475258_14 ABC transporter (Permease) K02026 - - 0.00000000000000000000000000000000000000000002006 173.0
TLS2_k127_4475258_15 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118 - - 0.000000000000000000000000000000000000000008079 167.0
TLS2_k127_4475258_16 zinc-ribbon domain - - - 0.0000000000000000000000000000008954 128.0
TLS2_k127_4475258_17 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000000002451 115.0
TLS2_k127_4475258_18 subunit of a heme lyase K02200 - - 0.0000000000000002376 81.0
TLS2_k127_4475258_19 Immunoglobulin-like domain of bacterial spore germination - - - 0.00000000001068 78.0
TLS2_k127_4475258_2 Protein of unknown function (DUF1800) - - - 1.246e-199 637.0
TLS2_k127_4475258_20 Bacterial extracellular solute-binding protein K05813 - - 0.0000008685 61.0
TLS2_k127_4475258_3 translation release factor activity K03265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 471.0
TLS2_k127_4475258_4 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 422.0
TLS2_k127_4475258_5 PFAM phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 422.0
TLS2_k127_4475258_6 Cysteine-rich domain K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 377.0
TLS2_k127_4475258_7 PFAM Haloacid dehalogenase domain protein hydrolase K02566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 349.0
TLS2_k127_4475258_8 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 342.0
TLS2_k127_4475258_9 Iron-sulfur cluster binding protein K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 332.0
TLS2_k127_4475754_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.831e-299 929.0
TLS2_k127_4475754_1 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 377.0
TLS2_k127_4475754_2 Threonyl alanyl tRNA synthetase SAD K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006274 365.0
TLS2_k127_4475754_3 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000001728 254.0
TLS2_k127_4487488_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000009341 216.0
TLS2_k127_449693_0 Carbamoyl-phosphate synthetase large chain domain protein K01955 - 6.3.5.5 0.0 1310.0
TLS2_k127_449693_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004838 389.0
TLS2_k127_449693_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000005006 204.0
TLS2_k127_449693_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000000000001624 189.0
TLS2_k127_449693_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000025 184.0
TLS2_k127_449693_5 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000005587 173.0
TLS2_k127_449693_6 AraC-like ligand binding domain - - - 0.00000000000000000000000000002056 124.0
TLS2_k127_449693_7 Protein conserved in bacteria - - - 0.000000000000000000000000001524 116.0
TLS2_k127_449693_8 High potential iron-sulfur protein - - - 0.000000000000004097 80.0
TLS2_k127_449693_9 Protein of unknown function (DUF433) - - - 0.000008774 49.0
TLS2_k127_4503767_0 PFAM ABC transporter related K06158 - - 6.909e-283 882.0
TLS2_k127_4503767_1 valine-pyruvate transaminase activity K00835 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009042,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0030632,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 510.0
TLS2_k127_4503767_2 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000006591 98.0
TLS2_k127_4507069_0 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 526.0
TLS2_k127_4507069_1 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004941 328.0
TLS2_k127_4507069_2 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000168 264.0
TLS2_k127_4507069_3 PFAM Glycosyl transferase, group 1 K13057 - 2.4.1.245 0.000000000000000000000000000000000000000000000000000000000003029 211.0
TLS2_k127_4507069_4 dehydrogenases and related proteins K22230 - - 0.00000000000000000000000000000000000000000000000000001036 202.0
TLS2_k127_4507069_5 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000001515 118.0
TLS2_k127_4507069_6 - - - - 0.0000002164 56.0
TLS2_k127_4511540_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520,K11177 - 1.17.1.4,1.2.5.3 4.454e-320 997.0
TLS2_k127_4511540_1 Binding-protein-dependent transport system inner membrane component K02025 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 398.0
TLS2_k127_4511540_10 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008076 272.0
TLS2_k127_4511540_11 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000004265 238.0
TLS2_k127_4511540_12 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000003566 213.0
TLS2_k127_4511540_13 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000006134 171.0
TLS2_k127_4511540_14 XdhC and CoxI family - - - 0.00000000000000000000000000000000000003635 145.0
TLS2_k127_4511540_15 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000004637 154.0
TLS2_k127_4511540_16 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000000000000000000000000000004814 143.0
TLS2_k127_4511540_17 Transcriptional regulator, GntR family - - - 0.00000000000000000000008298 108.0
TLS2_k127_4511540_18 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000002505 92.0
TLS2_k127_4511540_19 WD domain, G-beta repeat - - - 0.00000000000003938 76.0
TLS2_k127_4511540_2 ABC-type sugar transport system periplasmic component K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 388.0
TLS2_k127_4511540_20 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000008688 73.0
TLS2_k127_4511540_3 Belongs to the glycosyl hydrolase 32 family K01193,K01212 - 3.2.1.26,3.2.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 364.0
TLS2_k127_4511540_4 COG0714 MoxR-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 349.0
TLS2_k127_4511540_5 Binding-protein-dependent transport system inner membrane component K17243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009217 344.0
TLS2_k127_4511540_6 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 337.0
TLS2_k127_4511540_7 SMART von Willebrand factor, type A K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 341.0
TLS2_k127_4511540_8 e3 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 335.0
TLS2_k127_4511540_9 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005924 278.0
TLS2_k127_4518446_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 571.0
TLS2_k127_4518446_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000002448 181.0
TLS2_k127_4518446_2 hydrolases of the HAD superfamily - - - 0.0000000000000000000000000001047 125.0
TLS2_k127_4518446_3 O-antigen ligase like membrane protein - - - 0.0000000000000000002138 104.0
TLS2_k127_4518549_0 PFAM Mandelate racemase muconate lactonizing - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007278 387.0
TLS2_k127_4518549_1 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000002 206.0
TLS2_k127_4518549_2 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000000000000000000000001324 192.0
TLS2_k127_4518549_3 cellulase activity K01183 - 3.2.1.14 0.0000000000000000000000000000000000000000000000342 196.0
TLS2_k127_4518549_4 ABC-type sugar transport system, permease component K02026 - - 0.000000000007118 67.0
TLS2_k127_4518549_5 Belongs to the peptidase S8 family K13276,K17734 - - 0.0000000000116 79.0
TLS2_k127_4519707_0 Domain of unknown function (DUF4037) - - - 0.00000000000000000000000000000000001417 147.0
TLS2_k127_4519707_1 Transposase IS66 family - - - 0.00000000000000000000000000000467 133.0
TLS2_k127_4519707_2 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000002011 114.0
TLS2_k127_4519707_3 Staphylococcal nuclease homologues - - - 0.00000000003496 75.0
TLS2_k127_4525205_0 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006644 455.0
TLS2_k127_4525205_1 transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007028 420.0
TLS2_k127_4525205_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000001143 218.0
TLS2_k127_4525205_3 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000004568 210.0
TLS2_k127_4525205_4 Protein of unknown function (DUF2442) - - - 0.000000000000000000000000000000000000000001769 157.0
TLS2_k127_4525205_5 BrnA antitoxin of type II toxin-antitoxin system - - - 0.00000000000000000000003438 101.0
TLS2_k127_4525205_6 Domain of unknown function (DUF4160) - - - 0.00000000000000001002 84.0
TLS2_k127_4528475_0 ATPase associated with various cellular activities, AAA_5 K03696 - - 0.0 1304.0
TLS2_k127_4528475_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 317.0
TLS2_k127_4528475_2 response to heat K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 305.0
TLS2_k127_4528475_3 Response regulator receiver domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001169 268.0
TLS2_k127_4528475_4 PFAM beta-lactamase domain protein K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000002433 218.0
TLS2_k127_4528475_5 - - - - 0.0000000000000000000000000000000009254 134.0
TLS2_k127_4528475_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000005985 74.0
TLS2_k127_4528475_7 Multicopper oxidase K04753 - - 0.0000000627 59.0
TLS2_k127_4532165_0 Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde K05829 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 560.0
TLS2_k127_4532165_1 Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine K05830 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009051 544.0
TLS2_k127_4532165_10 Mazg nucleotide pyrophosphohydrolase - - - 0.00000000000000000000000000000000000000000000000000002571 193.0
TLS2_k127_4532165_11 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000001351 150.0
TLS2_k127_4532165_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000000006975 117.0
TLS2_k127_4532165_13 PFAM phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000009904 116.0
TLS2_k127_4532165_14 TIGRFAM lysine biosynthesis protein LysW K05826 - - 0.0000000000000000000008417 96.0
TLS2_k127_4532165_15 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000002129 98.0
TLS2_k127_4532165_2 Belongs to the RimK family K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 502.0
TLS2_k127_4532165_3 Belongs to the acetylglutamate kinase family. LysZ subfamily K05828 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007446 451.0
TLS2_k127_4532165_4 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 433.0
TLS2_k127_4532165_5 Involved in the tonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 379.0
TLS2_k127_4532165_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000504 276.0
TLS2_k127_4532165_7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000003491 261.0
TLS2_k127_4532165_8 nUDIX hydrolase K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000005842 233.0
TLS2_k127_4532165_9 Transcriptional regulator K03724 - - 0.00000000000000000000000000000000000000000000000000000000004946 209.0
TLS2_k127_4533699_0 pyridoxamine 5-phosphate - - - 0.00000000000000000000000000000000000002702 146.0
TLS2_k127_4533699_1 ketosteroid isomerase - - - 0.000000000000000000000000000000008927 131.0
TLS2_k127_4533699_2 NmrA-like family - - - 0.00000000000000000000000001744 114.0
TLS2_k127_4533699_3 SnoaL-like polyketide cyclase - - - 0.00000000000001218 79.0
TLS2_k127_4533699_4 phosphorelay signal transduction system - - - 0.0005623 44.0
TLS2_k127_4545102_0 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 479.0
TLS2_k127_4545102_1 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 400.0
TLS2_k127_4545102_2 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 351.0
TLS2_k127_4545102_3 LysM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002082 289.0
TLS2_k127_4545102_4 Cytochrome c K02275,K17223 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000001776 211.0
TLS2_k127_4545102_5 protein conserved in bacteria - - - 0.000000000000000000000000000000000001521 159.0
TLS2_k127_4545102_6 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.00000000000000000000000000009055 115.0
TLS2_k127_4547051_0 (ABC) transporter K06020 GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 3.505e-307 947.0
TLS2_k127_4547051_1 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004964 271.0
TLS2_k127_4547051_2 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000006456 132.0
TLS2_k127_4547051_3 Predicted permease K07089 - - 0.000000001173 62.0
TLS2_k127_454870_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.777e-209 663.0
TLS2_k127_454870_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 600.0
TLS2_k127_454870_2 Amidohydrolase family K01464,K01466 - 3.5.2.2,3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 578.0
TLS2_k127_454870_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 433.0
TLS2_k127_454870_4 PFAM mannose-6-phosphate isomerase type I K01809 - 5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 405.0
TLS2_k127_454870_5 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006308 299.0
TLS2_k127_454870_6 PFAM DUF218 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001846 244.0
TLS2_k127_454870_7 PFAM Maf family protein K06287 - - 0.000000000000000000000000000000000000000000000000000000004338 206.0
TLS2_k127_454870_8 acetyltransferase K03827 - - 0.000006353 50.0
TLS2_k127_4552348_0 PFAM sugar transferase - - - 2.935e-225 706.0
TLS2_k127_4552348_1 peptidase dimerisation domain protein - - - 2.259e-201 637.0
TLS2_k127_4552348_10 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 347.0
TLS2_k127_4552348_11 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006964 318.0
TLS2_k127_4552348_12 PFAM Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000004642 220.0
TLS2_k127_4552348_13 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000000000000000000000000000000000004203 183.0
TLS2_k127_4552348_14 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000001503 170.0
TLS2_k127_4552348_15 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000003871 114.0
TLS2_k127_4552348_2 ABC transporter transmembrane region K06147,K06148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 581.0
TLS2_k127_4552348_3 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 526.0
TLS2_k127_4552348_4 ATPase involved in DNA repair K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 533.0
TLS2_k127_4552348_5 PFAM Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 430.0
TLS2_k127_4552348_6 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 427.0
TLS2_k127_4552348_7 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 412.0
TLS2_k127_4552348_8 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 409.0
TLS2_k127_4552348_9 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 383.0
TLS2_k127_4576114_0 peptidyl-tyrosine sulfation - - - 1.445e-261 824.0
TLS2_k127_4576114_1 Sodium:sulfate symporter transmembrane region K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 534.0
TLS2_k127_4576114_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 395.0
TLS2_k127_4576114_3 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000007793 151.0
TLS2_k127_4576114_4 - - - - 0.00000000000000000000000000009539 119.0
TLS2_k127_460563_0 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 569.0
TLS2_k127_460563_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008197 308.0
TLS2_k127_460563_3 - - - - 0.000000000000000000000000000000000000000000004562 172.0
TLS2_k127_4615903_0 Aldehyde dehydrogenase family K00135,K07248 - 1.2.1.16,1.2.1.20,1.2.1.21,1.2.1.22,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 532.0
TLS2_k127_4615903_1 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 380.0
TLS2_k127_4615903_2 Aldo Keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 371.0
TLS2_k127_4615903_3 chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.00000000000000000000000000000000000000000007626 164.0
TLS2_k127_4615903_4 translation initiation factor activity K00700,K12132,K18376,K18682 - 2.4.1.18,2.7.11.1 0.00000000000000697 79.0
TLS2_k127_4615903_5 Sortilin, neurotensin receptor 3, - - - 0.00009826 54.0
TLS2_k127_461961_0 Vitamin B12 dependent methionine synthase, activation K00548 - 2.1.1.13 2.004e-260 816.0
TLS2_k127_461961_1 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 396.0
TLS2_k127_461961_2 PFAM aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 307.0
TLS2_k127_461961_3 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006972 305.0
TLS2_k127_461961_4 F420-0:Gamma-glutamyl ligase K12234,K22099 - 6.3.2.12,6.3.2.17,6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000001356 151.0
TLS2_k127_461961_5 PIN domain - - - 0.00000000000000003155 83.0
TLS2_k127_461961_6 PFAM PIN domain - - - 0.000000000000004083 76.0
TLS2_k127_461961_7 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000001056 76.0
TLS2_k127_461961_8 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000001835 75.0
TLS2_k127_461961_9 - - - - 0.00000001312 58.0
TLS2_k127_4620594_0 PFAM histone deacetylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 426.0
TLS2_k127_4620594_1 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 398.0
TLS2_k127_4620594_10 PFAM response regulator receiveR - - - 0.000000000000000000000000000000000000000000000000000002952 194.0
TLS2_k127_4620594_11 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000001962 183.0
TLS2_k127_4620594_12 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000006412 177.0
TLS2_k127_4620594_13 Domain of unknown function (DUF362) - - - 0.0000000000000001372 93.0
TLS2_k127_4620594_14 Domain of unknown function DUF1829 - - - 0.0000001585 62.0
TLS2_k127_4620594_2 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 413.0
TLS2_k127_4620594_3 Malate/L-lactate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 359.0
TLS2_k127_4620594_4 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 369.0
TLS2_k127_4620594_5 impB/mucB/samB family K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 302.0
TLS2_k127_4620594_6 UbiA prenyltransferase family K02548 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007713 291.0
TLS2_k127_4620594_7 PFAM aminotransferase, class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003006 276.0
TLS2_k127_4620594_8 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002148 266.0
TLS2_k127_4620594_9 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000000000003222 226.0
TLS2_k127_4658622_0 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006339 254.0
TLS2_k127_4658622_1 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000103 235.0
TLS2_k127_4658622_2 dioxygenase activity K18565 - - 0.000000000000000000000000000006577 123.0
TLS2_k127_4658622_3 Cell Wall K01448 - 3.5.1.28 0.00000000000000000000001024 116.0
TLS2_k127_4658622_4 COGs COG1653 ABC-type sugar transport system periplasmic component K02027 - - 0.000000000000002566 89.0
TLS2_k127_4661378_0 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007873 557.0
TLS2_k127_4661378_1 FG-GAP repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006106 518.0
TLS2_k127_4661378_10 Domain of unknown function (DUF4166) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 338.0
TLS2_k127_4661378_11 DoxX-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 334.0
TLS2_k127_4661378_12 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 329.0
TLS2_k127_4661378_13 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 325.0
TLS2_k127_4661378_14 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 298.0
TLS2_k127_4661378_15 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 309.0
TLS2_k127_4661378_16 binding-protein-dependent transport systems inner membrane component K02026,K10242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006284 282.0
TLS2_k127_4661378_17 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000000000000000000002943 243.0
TLS2_k127_4661378_18 Acetamidase/Formamidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000003805 194.0
TLS2_k127_4661378_19 PhoQ Sensor K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000002762 149.0
TLS2_k127_4661378_2 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 502.0
TLS2_k127_4661378_21 Periplasmic binding protein-like domain K02529 - - 0.000000000000000000000000001278 125.0
TLS2_k127_4661378_22 PFAM extracellular solute-binding protein family 1 K02027 - - 0.0000000000000000002898 101.0
TLS2_k127_4661378_3 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 486.0
TLS2_k127_4661378_4 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 474.0
TLS2_k127_4661378_5 PFAM peptidase M19 renal dipeptidase K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 437.0
TLS2_k127_4661378_6 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 443.0
TLS2_k127_4661378_7 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 421.0
TLS2_k127_4661378_8 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 437.0
TLS2_k127_4661378_9 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 415.0
TLS2_k127_4662132_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K01507,K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 386.0
TLS2_k127_4662132_1 PFAM Helix-turn-helix, type 11 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 313.0
TLS2_k127_4662132_2 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 305.0
TLS2_k127_4662132_3 Short chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002622 278.0
TLS2_k127_4671041_0 Belongs to the IlvD Edd family K22396 - 4.2.1.82 1.246e-298 929.0
TLS2_k127_4671041_1 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01740 - 2.5.1.49 3.189e-232 725.0
TLS2_k127_4671041_10 Acetyltransferase (GNAT) domain - - - 0.0000000000003048 77.0
TLS2_k127_4671041_11 Belongs to the peptidase S8 family - - - 0.00004403 56.0
TLS2_k127_4671041_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 2.221e-208 655.0
TLS2_k127_4671041_3 Belongs to the PdxA family K22024 - 1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 314.0
TLS2_k127_4671041_4 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 296.0
TLS2_k127_4671041_5 Malate/L-lactate dehydrogenase K13574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005822 262.0
TLS2_k127_4671041_6 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003117 249.0
TLS2_k127_4671041_7 converts alpha-aldose to the beta-anomer - - - 0.000000000000000000000000000000000000000000000000000000002009 212.0
TLS2_k127_4671041_8 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000004357 187.0
TLS2_k127_4671041_9 glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000000000008466 91.0
TLS2_k127_4673892_0 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 381.0
TLS2_k127_4673892_1 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00847,K00852 GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.15,2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 357.0
TLS2_k127_4673892_2 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 353.0
TLS2_k127_4673892_3 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 359.0
TLS2_k127_4673892_4 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009202 336.0
TLS2_k127_4673892_5 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 306.0
TLS2_k127_4673892_6 tRNA wobble adenosine to inosine editing - - - 0.000000000000000000000000000000000001716 147.0
TLS2_k127_4673892_7 ACT domain K09707 - - 0.00000000000000000000000000002463 126.0
TLS2_k127_4673892_8 Ion channel - - - 0.000000000000000000000003867 110.0
TLS2_k127_4674863_0 Pfam:Methyltransf_6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008851 359.0
TLS2_k127_4674863_1 ABC-type sugar transport systems, permease components K02025 - - 0.000000000000000000000000000000000000000000000000000000000001371 219.0
TLS2_k127_4674863_2 ABC-type sugar transport system, periplasmic component K02027 - - 0.0000000000000000000000000000000000000001166 167.0
TLS2_k127_4686529_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 2.456e-261 816.0
TLS2_k127_4686529_1 Hydantoinaseoxoprolinase domain protein K01473 - 3.5.2.14 8.802e-249 788.0
TLS2_k127_4686529_2 PFAM ABC transporter related K02056 - 3.6.3.17 3.878e-198 631.0
TLS2_k127_4686529_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000907 565.0
TLS2_k127_4686529_4 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 529.0
TLS2_k127_4686529_5 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 526.0
TLS2_k127_4686529_6 PFAM basic membrane lipoprotein K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 467.0
TLS2_k127_4686529_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000003401 157.0
TLS2_k127_4686529_9 - - - - 0.0001242 44.0
TLS2_k127_4687468_0 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591,K13421 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 568.0
TLS2_k127_4687468_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004341 527.0
TLS2_k127_4687468_10 PFAM Integrase catalytic region K07497 - - 0.000000000000000000000000000000000000000000000000007591 186.0
TLS2_k127_4687468_12 PFAM metal-dependent phosphohydrolase, HD sub domain K07023 - - 0.0000000000000000000000000000000000000000007738 164.0
TLS2_k127_4687468_13 GtrA-like protein - - - 0.0000000000000000000000000000000000000000008607 161.0
TLS2_k127_4687468_14 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000000000001352 102.0
TLS2_k127_4687468_15 PFAM Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.000000000000002599 87.0
TLS2_k127_4687468_16 PFAM TPR repeat-containing protein - - - 0.0000001014 66.0
TLS2_k127_4687468_2 CpXC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 493.0
TLS2_k127_4687468_3 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 458.0
TLS2_k127_4687468_4 PFAM molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 411.0
TLS2_k127_4687468_5 PFAM O-antigen polymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008389 396.0
TLS2_k127_4687468_6 TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 387.0
TLS2_k127_4687468_7 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004053 267.0
TLS2_k127_4687468_8 PFAM thioesterase superfamily protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001198 225.0
TLS2_k127_4687468_9 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000009621 222.0
TLS2_k127_4699411_0 DbpA RNA binding domain K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 520.0
TLS2_k127_4699411_1 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005633 255.0
TLS2_k127_4699411_2 - - - - 0.000000000000000000000000000000000000000000000000000000006232 205.0
TLS2_k127_4702450_0 L-phenylalanine transmembrane transporter activity K01997,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 479.0
TLS2_k127_4702450_1 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 382.0
TLS2_k127_4702450_2 PFAM ABC transporter related K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 371.0
TLS2_k127_4702450_3 AI-2E family transporter - - - 0.00000000000000000000000000000000006845 138.0
TLS2_k127_4720253_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.0 1023.0
TLS2_k127_4720253_1 L-lactate permease K03303 - - 7.683e-221 698.0
TLS2_k127_4720253_10 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000005187 260.0
TLS2_k127_4720253_11 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006521 258.0
TLS2_k127_4720253_12 Carotenoid biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000181 253.0
TLS2_k127_4720253_13 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001264 250.0
TLS2_k127_4720253_14 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001975 235.0
TLS2_k127_4720253_15 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term - - - 0.0000000000000000000000000000000000000000000000000000001183 204.0
TLS2_k127_4720253_16 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000001187 186.0
TLS2_k127_4720253_17 Tautomerase enzyme - - - 0.000000000000000000000000000000000000000000003402 168.0
TLS2_k127_4720253_18 TIGRFAM lycopene cyclase domain K22502 - 5.5.1.19 0.00000000000000000000000000000000000000000002898 176.0
TLS2_k127_4720253_19 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates - - - 0.000000000000000000000000000000000000000004677 158.0
TLS2_k127_4720253_2 COG1233 Phytoene dehydrogenase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 547.0
TLS2_k127_4720253_20 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K07589 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564 1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8 0.00000000000000000000000000000000002697 138.0
TLS2_k127_4720253_21 Aldo/keto reductase family - - - 0.00000000000000000000007825 105.0
TLS2_k127_4720253_22 Glutamine amidotransferase class-I - - - 0.0000000000000000000376 96.0
TLS2_k127_4720253_23 GDP-mannose 4,6 dehydratase - - - 0.00000000009095 71.0
TLS2_k127_4720253_24 Glyoxalase-like domain K08234 - - 0.000007548 57.0
TLS2_k127_4720253_25 Male sterility protein K01784 - 5.1.3.2 0.00001391 55.0
TLS2_k127_4720253_3 Voltage-gated potassium channel K19265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 463.0
TLS2_k127_4720253_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 451.0
TLS2_k127_4720253_5 Catalyzes the reversible oxidation of malate to oxaloacetate K00016 - 1.1.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 421.0
TLS2_k127_4720253_6 NAD-dependent epimerase dehydratase K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007614 374.0
TLS2_k127_4720253_7 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 376.0
TLS2_k127_4720253_8 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008988 282.0
TLS2_k127_4720253_9 Pyridoxal-phosphate dependent enzyme K05396,K17950 - 4.4.1.15,4.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000006243 271.0
TLS2_k127_4720410_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 464.0
TLS2_k127_4720410_1 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000435 370.0
TLS2_k127_4720410_2 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000576 283.0
TLS2_k127_4720410_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000004989 182.0
TLS2_k127_4720410_4 Cytochrome c - - - 0.000000000000000000000000000000000000000000001425 179.0
TLS2_k127_4720410_5 Tellurite resistance protein TehB - - - 0.00000000000000000000000007491 116.0
TLS2_k127_4720410_6 Beta-lactamase - - - 0.0000000000000000000000002872 118.0
TLS2_k127_4724618_0 1,4-alpha-glucan branching enzyme activity K00700,K01187,K01236,K17734 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,3.2.1.141,3.2.1.20 5.606e-285 896.0
TLS2_k127_4724618_1 TIGRFAM methylmalonyl-CoA mutase, large subunit K01847,K01848 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 527.0
TLS2_k127_4724618_10 Pfam:DUF59 - - - 0.0000000000000000000000000000000000000000003066 162.0
TLS2_k127_4724618_11 GGDEF domain - - - 0.000000000000000000000000000000000002759 153.0
TLS2_k127_4724618_12 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000009766 117.0
TLS2_k127_4724618_13 Acetyltransferase (GNAT) domain - - - 0.0000001343 63.0
TLS2_k127_4724618_2 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 396.0
TLS2_k127_4724618_3 involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 346.0
TLS2_k127_4724618_4 TIGRFAM mevalonate kinase K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 293.0
TLS2_k127_4724618_5 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443,K16786,K16787 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009103 292.0
TLS2_k127_4724618_6 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000113 284.0
TLS2_k127_4724618_7 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003073 273.0
TLS2_k127_4724618_8 PFAM restriction endonuclease K07448 - - 0.0000000000000000000000000000000000000000000000000001556 199.0
TLS2_k127_4724618_9 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000001783 186.0
TLS2_k127_4778524_0 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 367.0
TLS2_k127_4778524_1 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 360.0
TLS2_k127_4778524_2 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 348.0
TLS2_k127_4778524_3 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000001379 215.0
TLS2_k127_4778524_4 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000004352 195.0
TLS2_k127_4778524_6 Trypsin - - - 0.000000000000000000000000002219 129.0
TLS2_k127_4786658_0 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 347.0
TLS2_k127_4786658_1 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006113 283.0
TLS2_k127_4786658_2 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000007482 240.0
TLS2_k127_4786658_3 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000184 175.0
TLS2_k127_4786658_4 HpcH/HpaI aldolase/citrate lyase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.000000002196 67.0
TLS2_k127_4792177_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520,K20447,K20448 - 1.17.1.5,1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009431 619.0
TLS2_k127_4792177_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008515 475.0
TLS2_k127_4792177_2 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 304.0
TLS2_k127_4792177_3 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000462 146.0
TLS2_k127_4792177_4 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000003146 126.0
TLS2_k127_4792177_5 protein conserved in bacteria K09793 - - 0.000000000000000531 85.0
TLS2_k127_4792177_6 - - - - 0.0000001246 53.0
TLS2_k127_4817353_0 regulatory protein LysR K21703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 362.0
TLS2_k127_4817353_1 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000002557 130.0
TLS2_k127_4817353_2 Methyltransferase type 11 - - - 0.0000000001354 61.0
TLS2_k127_4817353_3 PFAM beta-lactamase domain protein K01069 - 3.1.2.6 0.0001919 44.0
TLS2_k127_4821679_0 PFAM multicopper oxidase type 2 - - - 1.212e-297 931.0
TLS2_k127_4821679_1 PFAM major facilitator superfamily MFS_1 K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 393.0
TLS2_k127_4821679_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000001222 112.0
TLS2_k127_4821679_5 - - - - 0.00000000000000000001114 93.0
TLS2_k127_4827574_0 Molecular chaperone. Has ATPase activity K04079 - - 1.273e-253 797.0
TLS2_k127_4827574_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 1.874e-207 654.0
TLS2_k127_4827574_10 peptidoglycan turnover - - - 0.0000000000000000000000000000000000000000000000000000000000000008538 233.0
TLS2_k127_4827574_11 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000006409 203.0
TLS2_k127_4827574_12 sh3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000582 207.0
TLS2_k127_4827574_13 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000002222 79.0
TLS2_k127_4827574_14 Transposase DDE domain - - - 0.00000004784 63.0
TLS2_k127_4827574_15 Sulfatase - - - 0.0004631 45.0
TLS2_k127_4827574_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 3.617e-207 651.0
TLS2_k127_4827574_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 598.0
TLS2_k127_4827574_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 582.0
TLS2_k127_4827574_5 PFAM glycoside hydrolase family 3 K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 394.0
TLS2_k127_4827574_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 333.0
TLS2_k127_4827574_7 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 325.0
TLS2_k127_4827574_8 Bacterial PH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 288.0
TLS2_k127_4827574_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000002845 239.0
TLS2_k127_4833727_0 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 369.0
TLS2_k127_4833727_1 cellulose binding - - - 0.000000000000003105 81.0
TLS2_k127_4833727_2 transferase activity, transferring glycosyl groups - - - 0.000000000002551 73.0
TLS2_k127_4836466_0 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 317.0
TLS2_k127_4836466_1 Binding-protein-dependent transport system inner membrane component K10118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 308.0
TLS2_k127_4836466_10 Dehydrogenase K00004,K00098 - 1.1.1.264,1.1.1.303,1.1.1.4 0.0004832 49.0
TLS2_k127_4836466_2 Periplasmic binding protein-like domain K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009759 299.0
TLS2_k127_4836466_3 Binding-protein-dependent transport system inner membrane component K10119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000287 280.0
TLS2_k127_4836466_4 Bacterial extracellular solute-binding protein K10117 - - 0.00000000000000000000000000000000000000000000000000000000000000000000147 253.0
TLS2_k127_4836466_6 heme binding K21471 - - 0.000000000000000000000000000000000000000000000873 173.0
TLS2_k127_4836466_8 Zinc-binding dehydrogenase - - - 0.000000000000000000000000315 111.0
TLS2_k127_4836466_9 Regulatory protein, FmdB family - - - 0.000000000000000000002686 100.0
TLS2_k127_4858064_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 436.0
TLS2_k127_4858064_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 311.0
TLS2_k127_4858064_2 ATP hydrolysis coupled proton transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 306.0
TLS2_k127_4858064_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 290.0
TLS2_k127_4858064_5 - - - - 0.000000000000000000000000000000000000000000000000000002259 201.0
TLS2_k127_4858064_6 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000000000000000000001025 174.0
TLS2_k127_4873486_0 ABC transporter, transmembrane region K06147,K18890 - - 2.272e-227 719.0
TLS2_k127_4873486_1 PFAM Mandelate racemase muconate lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 539.0
TLS2_k127_4873486_2 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 292.0
TLS2_k127_4873486_3 carbohydrate kinase FGGY K00851 - 2.7.1.12 0.0000000000000007121 82.0
TLS2_k127_4881525_0 Tyrosine phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000003784 177.0
TLS2_k127_4881525_1 - - - - 0.00000000000000000000000001631 112.0
TLS2_k127_4889902_0 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 361.0
TLS2_k127_4889902_1 Belongs to the glycosyl hydrolase 32 family K03332 - 3.2.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 298.0
TLS2_k127_4889902_2 Putative RNA methylase family UPF0020 K12297 - 2.1.1.173,2.1.1.264 0.000000000000000000000000000000000000000001196 170.0
TLS2_k127_4889902_3 NUDIX domain - - - 0.00000000000000000000000002117 114.0
TLS2_k127_4910254_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 569.0
TLS2_k127_4910254_1 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress - - - 0.00000000000000000000000000000000000000000000000000000001144 206.0
TLS2_k127_4910254_2 SpoU rRNA Methylase family - - - 0.0000000000000000000000000000000000000000000025 168.0
TLS2_k127_4910254_3 KR domain K00076 - 1.1.1.159 0.00000000000000000000000000000000000001253 154.0
TLS2_k127_4910254_4 PFAM Xylose - - - 0.000000000000000000000005222 113.0
TLS2_k127_4910254_5 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000007822 96.0
TLS2_k127_4910254_6 - - - - 0.000000000001982 75.0
TLS2_k127_4916209_0 helix_turn_helix, Lux Regulon K03556 - - 6.863e-199 653.0
TLS2_k127_4916209_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 525.0
TLS2_k127_4916209_10 Phosphoribosyl transferase domain K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000431 259.0
TLS2_k127_4916209_11 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000272 250.0
TLS2_k127_4916209_12 Predicted membrane protein (DUF2085) - - - 0.000000000000000000000000000000000000000000000000000000000000003447 226.0
TLS2_k127_4916209_13 sigma-70 region 2 domain protein K03088 - - 0.00000000000000000000000000000000000000000000000000000002402 205.0
TLS2_k127_4916209_14 Histidine kinase K07777 - 2.7.13.3 0.00000000000000000000000000000000000000000000008889 188.0
TLS2_k127_4916209_15 YtkA-like - - - 0.0000000000000000000000000000000000000000000003583 173.0
TLS2_k127_4916209_16 Ferredoxin - - - 0.00000000000000000000000000000000000000003611 158.0
TLS2_k127_4916209_17 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000002044 122.0
TLS2_k127_4916209_18 Protein of unknown function (DUF3105) - - - 0.00000000000000000000000007313 116.0
TLS2_k127_4916209_19 Protein of unknown function with PCYCGC motif - - - 0.0000000000000000003366 94.0
TLS2_k127_4916209_2 electron transfer activity K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 517.0
TLS2_k127_4916209_20 - - - - 0.00000000000005451 74.0
TLS2_k127_4916209_21 InterPro IPR011467 - - - 0.00000008391 59.0
TLS2_k127_4916209_22 Heavy-metal-associated domain K07213,K17686 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 3.6.3.54 0.0002392 48.0
TLS2_k127_4916209_3 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 477.0
TLS2_k127_4916209_4 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005689 477.0
TLS2_k127_4916209_5 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004877 387.0
TLS2_k127_4916209_6 sequence-specific DNA binding K18199 - 4.2.1.103 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 311.0
TLS2_k127_4916209_7 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000056 310.0
TLS2_k127_4916209_8 Haloacid dehalogenase domain protein hydrolase, type 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 289.0
TLS2_k127_4916209_9 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000113 300.0
TLS2_k127_4916576_0 photoreceptor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 436.0
TLS2_k127_4916576_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 336.0
TLS2_k127_4916576_2 PFAM Cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000000000000000000000000000000000001737 213.0
TLS2_k127_4916576_3 - - - - 0.00000000000000000000000000000000000000000000001113 173.0
TLS2_k127_4916576_4 Histidine kinase-like ATPase domain - - - 0.000000000000000000000000000000000000001955 169.0
TLS2_k127_4916576_5 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000001701 150.0
TLS2_k127_4916576_6 Uncharacterized conserved protein (DUF2249) - - - 0.000000000000000000000000000001446 122.0
TLS2_k127_4916576_7 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000005808 115.0
TLS2_k127_4923747_0 PFAM sodium calcium exchanger membrane region K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 396.0
TLS2_k127_4923747_1 domain, Protein K09766 - - 0.000000000000000000000000005565 126.0
TLS2_k127_4935131_0 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 372.0
TLS2_k127_4935131_1 PUCC protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 338.0
TLS2_k127_4935131_2 Sugar (and other) transporter K08369 - - 0.0001081 55.0
TLS2_k127_4975368_0 Protein of unknown function (DUF4012) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 406.0
TLS2_k127_4975368_1 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000001328 166.0
TLS2_k127_4979627_0 ABC transporter transmembrane region K06147 - - 3.793e-260 814.0
TLS2_k127_4979627_1 ABC transporter transmembrane region K06147 - - 1.43e-214 686.0
TLS2_k127_4979627_10 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000002036 231.0
TLS2_k127_4979627_2 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 4.715e-200 645.0
TLS2_k127_4979627_3 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000681 451.0
TLS2_k127_4979627_4 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 385.0
TLS2_k127_4979627_5 histidine kinase, dimerisation and phosphoacceptor region K02480 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 328.0
TLS2_k127_4979627_6 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 295.0
TLS2_k127_4979627_7 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002364 273.0
TLS2_k127_4979627_8 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005696 251.0
TLS2_k127_4979627_9 transport system, periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000368 231.0
TLS2_k127_4980371_0 PFAM sugar transferase - - - 9.201e-195 619.0
TLS2_k127_4980371_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 304.0
TLS2_k127_4980371_2 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000223 282.0
TLS2_k127_4980371_3 COG0747 ABC-type dipeptide transport system, periplasmic component K12368 - - 0.0000000000000000000000000000000000000000002578 177.0
TLS2_k127_4980371_4 DNA-templated transcription, initiation K03088 - - 0.0000000000002302 78.0
TLS2_k127_4989446_0 serine-type peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 448.0
TLS2_k127_4989446_1 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K03338 - 2.7.1.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 425.0
TLS2_k127_4989446_2 PFAM Mandelate racemase muconate lactonizing enzyme K01683,K01684,K08323 GO:0000287,GO:0003674,GO:0005488,GO:0043167,GO:0043169,GO:0046872 4.2.1.5,4.2.1.6,4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008642 405.0
TLS2_k127_4989446_3 PFAM Myo-inositol catabolism IolB domain protein K03337 - 5.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 374.0
TLS2_k127_4989446_4 RNA cap guanine-N2 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 338.0
TLS2_k127_4989446_5 Belongs to the CinA family K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000001057 186.0
TLS2_k127_501228_0 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 4.89e-211 663.0
TLS2_k127_501228_1 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 397.0
TLS2_k127_501228_2 Inosine-uridine preferring nucleoside hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007677 390.0
TLS2_k127_501228_3 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 370.0
TLS2_k127_501228_4 Rieske-like [2Fe-2S] domain - - - 0.000000002702 59.0
TLS2_k127_5023956_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 6.463e-236 737.0
TLS2_k127_5023956_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 528.0
TLS2_k127_5023956_10 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 311.0
TLS2_k127_5023956_11 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 291.0
TLS2_k127_5023956_13 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.0000000000000000000000000000000000000000000000000000000005727 223.0
TLS2_k127_5023956_14 PFAM diacylglycerol kinase catalytic region - - - 0.00000000000000000000000000000000000000388 154.0
TLS2_k127_5023956_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 482.0
TLS2_k127_5023956_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 436.0
TLS2_k127_5023956_4 PFAM YbbR family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004502 446.0
TLS2_k127_5023956_5 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 418.0
TLS2_k127_5023956_6 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 353.0
TLS2_k127_5023956_7 SMART Nucleotide binding protein, PINc - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 352.0
TLS2_k127_5023956_8 PFAM metal-dependent phosphohydrolase, HD sub domain K09163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 339.0
TLS2_k127_5023956_9 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006867 334.0
TLS2_k127_5039187_0 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 409.0
TLS2_k127_5039187_1 PFAM Cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 350.0
TLS2_k127_5039187_10 Domain of unknown function (DUF4399) - - - 0.00000000000000000000000000000006581 145.0
TLS2_k127_5039187_11 serine threonine protein kinase - - - 0.00000000000000000001151 108.0
TLS2_k127_5039187_12 rRNA binding K02968 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000001176 94.0
TLS2_k127_5039187_14 pyridoxamine 5'-phosphate K07005 - - 0.00000001796 60.0
TLS2_k127_5039187_15 Glutaredoxin-like domain (DUF836) - - - 0.0000006295 55.0
TLS2_k127_5039187_2 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 343.0
TLS2_k127_5039187_3 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 311.0
TLS2_k127_5039187_4 PFAM ABC transporter related K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006373 290.0
TLS2_k127_5039187_5 FES K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000287 268.0
TLS2_k127_5039187_6 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003787 267.0
TLS2_k127_5039187_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002973 248.0
TLS2_k127_5039187_8 Predicted membrane protein (DUF2085) - - - 0.000000000000000000000000000000000000000000000000000000000000000003476 232.0
TLS2_k127_5039187_9 PFAM helix-turn-helix HxlR type - - - 0.00000000000000000000000000000000000000002318 158.0
TLS2_k127_5045517_0 Male sterility protein - - - 8.717e-262 864.0
TLS2_k127_5045517_2 - - - - 0.0002417 50.0
TLS2_k127_5049259_0 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 574.0
TLS2_k127_5049259_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006209 479.0
TLS2_k127_5049259_2 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 396.0
TLS2_k127_5049259_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 361.0
TLS2_k127_5052400_0 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008176 368.0
TLS2_k127_5052400_1 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004324 283.0
TLS2_k127_5052400_2 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000007148 241.0
TLS2_k127_5052400_3 glycosyl transferase family 2 K00786 - - 0.00000000000000000000000000000000000000000000000000000000009514 214.0
TLS2_k127_5052400_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000003837 142.0
TLS2_k127_5052400_6 Uncharacterized conserved protein (DUF2304) K09153 - - 0.00000000005042 70.0
TLS2_k127_5052400_7 CAAX protease self-immunity - - - 0.000000002302 60.0
TLS2_k127_5052400_8 peptidyl-tyrosine sulfation - - - 0.0005892 54.0
TLS2_k127_5081604_0 PFAM SNF2-related protein - - - 1.625e-253 823.0
TLS2_k127_5081604_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 2.645e-229 725.0
TLS2_k127_5081604_10 mandelate racemase muconate lactonizing K01684,K01781,K08323 - 4.2.1.6,4.2.1.8,5.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006523 312.0
TLS2_k127_5081604_11 N-terminal TM domain of oligopeptide transport permease C K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 297.0
TLS2_k127_5081604_12 Binding-protein-dependent transport system inner membrane component K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004036 278.0
TLS2_k127_5081604_13 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005527 271.0
TLS2_k127_5081604_14 transmembrane transport K02035,K15580 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006869,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015833,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042939,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006028 280.0
TLS2_k127_5081604_15 aminopeptidase activity K07004 - - 0.0000000000000000000000000000000000000000000000000000000000001204 236.0
TLS2_k127_5081604_16 zinc finger - - - 0.00000000000000000000000000000000000000000000003719 181.0
TLS2_k127_5081604_17 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.000000000000000000000000109 121.0
TLS2_k127_5081604_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 7.319e-215 672.0
TLS2_k127_5081604_3 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 485.0
TLS2_k127_5081604_4 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 476.0
TLS2_k127_5081604_5 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 443.0
TLS2_k127_5081604_6 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 423.0
TLS2_k127_5081604_7 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 368.0
TLS2_k127_5081604_8 carboxylic acid catabolic process K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008721 339.0
TLS2_k127_5081604_9 Protein of unknown function (DUF1298) K00635 - 2.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 324.0
TLS2_k127_5083892_0 FGGY family of carbohydrate kinases, N-terminal domain K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 3.412e-217 691.0
TLS2_k127_5083892_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 511.0
TLS2_k127_5083892_10 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000001078 239.0
TLS2_k127_5083892_11 ABC transporter substrate-binding protein K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000002918 252.0
TLS2_k127_5083892_12 enzyme related to lactoylglutathione lyase K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000348 235.0
TLS2_k127_5083892_13 Dak2 K05879 - 2.7.1.121 0.00000000000000000000000000000000000000000000000000000000685 207.0
TLS2_k127_5083892_14 ribonuclease activity - - - 0.0000000000000000000000000000000000000000000000005686 177.0
TLS2_k127_5083892_15 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000002945 159.0
TLS2_k127_5083892_16 TIGRFAM dihydroxyacetone kinase, phosphotransfer subunit K05881 - 2.7.1.121 0.000000000000000000000003662 107.0
TLS2_k127_5083892_17 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183,K11189,K11201 - 2.7.1.202,2.7.3.9 0.000000000005956 71.0
TLS2_k127_5083892_18 - - - - 0.00004694 49.0
TLS2_k127_5083892_2 ABC-type proline glycine betaine transport system permease component K02001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005714 480.0
TLS2_k127_5083892_3 MlrC C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000753 456.0
TLS2_k127_5083892_4 Dak1 domain K05878 - 2.7.1.121 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 402.0
TLS2_k127_5083892_5 ATPases associated with a variety of cellular activities K02000 - 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 383.0
TLS2_k127_5083892_6 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 380.0
TLS2_k127_5083892_7 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 310.0
TLS2_k127_5083892_8 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 296.0
TLS2_k127_5083892_9 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007157 284.0
TLS2_k127_5087656_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0 1279.0
TLS2_k127_5087656_1 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 462.0
TLS2_k127_5087656_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004951 248.0
TLS2_k127_5087656_11 Pyridoxal-phosphate dependent enzyme K05396,K17950 - 4.4.1.15,4.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000002645 234.0
TLS2_k127_5087656_12 PFAM Fe-S metabolism associated SufE K02426 - - 0.00000000000000000000000000000000000000000000000000000000000001294 218.0
TLS2_k127_5087656_13 response regulator K07667 - - 0.0000000000000000000000000000000000000000000000007872 184.0
TLS2_k127_5087656_14 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - - 0.0000000000000000000000000000000000007085 145.0
TLS2_k127_5087656_15 FtsZ-dependent cytokinesis K03975,K18292,K19302 GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0051301,GO:0071944 3.6.1.27,4.1.3.25 0.0000000000000000000000000043 123.0
TLS2_k127_5087656_16 Conserved repeat domain - - - 0.0000000000000000000000003084 120.0
TLS2_k127_5087656_17 sequence-specific DNA binding K07729 - - 0.0000000000000000000000306 104.0
TLS2_k127_5087656_18 blue (type 1) copper K00368 - 1.7.2.1 0.00000000000000007454 94.0
TLS2_k127_5087656_2 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004917 447.0
TLS2_k127_5087656_3 PFAM Polynucleotide adenylyltransferase region K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 424.0
TLS2_k127_5087656_5 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 302.0
TLS2_k127_5087656_6 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003749 292.0
TLS2_k127_5087656_7 PFAM Stage II sporulation E family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001429 280.0
TLS2_k127_5087656_8 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003539 256.0
TLS2_k127_5087656_9 Catalyzes the dehydration of D-mannonate K01686 - 4.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000004369 258.0
TLS2_k127_5090242_0 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 493.0
TLS2_k127_5090242_1 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 489.0
TLS2_k127_5090242_2 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 411.0
TLS2_k127_5090242_3 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 368.0
TLS2_k127_5090242_4 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005478 295.0
TLS2_k127_5090242_5 transcriptional regulator, LuxR family - - - 0.0000000000000000000000000003105 117.0
TLS2_k127_5090242_6 COGs COG3870 conserved - - - 0.000000000000000002379 94.0
TLS2_k127_5090242_7 Cyclic-di-AMP receptor - - - 0.00000000000000009246 89.0
TLS2_k127_5093267_0 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000001695 218.0
TLS2_k127_5093267_1 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 0.00000000000000000000000000000000001421 151.0
TLS2_k127_5118994_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000000000000002949 226.0
TLS2_k127_5118994_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000003751 122.0
TLS2_k127_5118994_2 Helix-hairpin-helix motif - - - 0.00001385 59.0
TLS2_k127_5123455_0 SMART alpha amylase catalytic sub domain K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 6.614e-232 727.0
TLS2_k127_5123455_1 lipid kinase, YegS Rv2252 BmrU family - - - 0.00000001793 58.0
TLS2_k127_5123455_2 Membrane - - - 0.0009394 52.0
TLS2_k127_5157839_0 Two component transcriptional regulator, winged helix family K07667,K07668 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 420.0
TLS2_k127_5157839_1 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 406.0
TLS2_k127_5157839_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 371.0
TLS2_k127_5157839_3 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000446 298.0
TLS2_k127_5157839_4 PFAM PemK-like protein K07171 - - 0.00000000000000000000000000002065 120.0
TLS2_k127_5157839_5 4Fe-4S double cluster binding domain K18979 - 1.17.99.6 0.0000000000000000006473 88.0
TLS2_k127_51654_0 Tetratricopeptide TPR_2 repeat protein - - - 0.0 1275.0
TLS2_k127_51654_1 PFAM NHL repeat containing protein - - - 0.0 1105.0
TLS2_k127_51654_10 Polyketide cyclase / dehydrase and lipid transport - - - 0.00006473 53.0
TLS2_k127_51654_2 amine dehydrogenase activity - - - 1.214e-255 832.0
TLS2_k127_51654_3 Uncharacterized membrane protein (DUF2298) - - - 9.946e-219 707.0
TLS2_k127_51654_4 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 594.0
TLS2_k127_51654_5 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007149 365.0
TLS2_k127_51654_6 Peptidoglycan-binding LysM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 328.0
TLS2_k127_51654_7 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000001948 264.0
TLS2_k127_51654_8 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000007169 241.0
TLS2_k127_51654_9 2 iron, 2 sulfur cluster binding K02823,K05368 - 1.16.1.3,1.5.1.41 0.00000000000000000000000000000000006357 145.0
TLS2_k127_5169788_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.197e-213 674.0
TLS2_k127_5169788_1 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000000000000000000001144 130.0
TLS2_k127_5169788_2 - - - - 0.00000000000000000000000008037 117.0
TLS2_k127_5169788_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0004827 43.0
TLS2_k127_5179153_0 (ABC) transporter - - - 5.718e-198 636.0
TLS2_k127_5179153_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004419 381.0
TLS2_k127_5179153_10 PFAM pentapeptide repeat protein - - - 0.0000000000000000008343 94.0
TLS2_k127_5179153_2 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 336.0
TLS2_k127_5179153_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 329.0
TLS2_k127_5179153_4 TupA-like ATPgrasp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 315.0
TLS2_k127_5179153_5 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 310.0
TLS2_k127_5179153_6 protein methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 292.0
TLS2_k127_5179153_7 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 293.0
TLS2_k127_5179153_8 Methyltransferase domain - - - 0.000000000000000000000000000001175 132.0
TLS2_k127_5179153_9 Protein conserved in bacteria K20444 - - 0.0000000000000000000003986 106.0
TLS2_k127_5200527_0 Sh3 type 3 domain protein K01448,K07448 - 3.5.1.28 1.546e-210 675.0
TLS2_k127_5200527_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 567.0
TLS2_k127_5200527_10 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 292.0
TLS2_k127_5200527_11 3-hydroxyanthranilate 3,4-dioxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000001129 216.0
TLS2_k127_5200527_12 Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000002602 144.0
TLS2_k127_5200527_13 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000007514 92.0
TLS2_k127_5200527_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 557.0
TLS2_k127_5200527_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009499 540.0
TLS2_k127_5200527_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 537.0
TLS2_k127_5200527_5 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 415.0
TLS2_k127_5200527_6 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 430.0
TLS2_k127_5200527_7 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032,K10823,K10824 - 3.6.3.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008524 402.0
TLS2_k127_5200527_8 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 392.0
TLS2_k127_5200527_9 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 321.0
TLS2_k127_5211438_0 Kelch repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 457.0
TLS2_k127_5211438_1 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002457 282.0
TLS2_k127_5211438_2 TIGRFAM molybdate ABC transporter, inner membrane subunit K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002428 247.0
TLS2_k127_5211438_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000000000000000000262 210.0
TLS2_k127_5211438_4 LVIVD repeat - - - 0.0000000000000008313 82.0
TLS2_k127_5211438_5 Glycosyl hydrolase catalytic core - - - 0.0000000001356 74.0
TLS2_k127_5213671_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1418.0
TLS2_k127_5213671_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 391.0
TLS2_k127_5213671_2 PFAM glycoside hydrolase, family 13 domain protein - - - 0.0000000000000000000000000000000001611 136.0
TLS2_k127_5220538_0 FtsX-like permease family K02004 - - 1.386e-197 634.0
TLS2_k127_5220538_1 Mandelate racemase muconate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 579.0
TLS2_k127_5220538_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 561.0
TLS2_k127_5220538_3 secretion protein HlyD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 392.0
TLS2_k127_5220538_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 312.0
TLS2_k127_5220538_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 298.0
TLS2_k127_5220538_6 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000002204 176.0
TLS2_k127_5220538_7 - - - - 0.00001996 51.0
TLS2_k127_5232335_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 1.689e-217 680.0
TLS2_k127_5232335_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 589.0
TLS2_k127_5232335_10 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000002314 265.0
TLS2_k127_5232335_12 PFAM Chorismate mutase of the AroH class K06208 - 5.4.99.5 0.00000000000000000000000000000000000000000000000000001325 196.0
TLS2_k127_5232335_13 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000002613 171.0
TLS2_k127_5232335_14 PFAM CoA-binding domain protein K06929 - - 0.0000000000000000000000000000000000000006062 153.0
TLS2_k127_5232335_15 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K07443 - - 0.0000000000000000000000000000000000006336 143.0
TLS2_k127_5232335_16 Transcriptional - - - 0.000000000000000000000000001151 115.0
TLS2_k127_5232335_18 YacP-like NYN domain K06962 - - 0.0000000000000000008254 96.0
TLS2_k127_5232335_19 Acetyltransferase (GNAT) domain - - - 0.00000000000000229 83.0
TLS2_k127_5232335_2 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008768 538.0
TLS2_k127_5232335_3 amino acid-binding ACT domain protein K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 442.0
TLS2_k127_5232335_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 405.0
TLS2_k127_5232335_5 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007871 402.0
TLS2_k127_5232335_6 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 399.0
TLS2_k127_5232335_7 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007506 320.0
TLS2_k127_5232335_8 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 314.0
TLS2_k127_5232335_9 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009608 280.0
TLS2_k127_5232708_0 PFAM glycosyl transferase, family 51 - - - 5.415e-245 791.0
TLS2_k127_5232708_1 COG2335, Secreted and surface protein containing fasciclin-like repeats K01119 - 3.1.3.6,3.1.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 413.0
TLS2_k127_5232708_2 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003735 387.0
TLS2_k127_5250607_0 dipeptide transport K02035 - - 0.0 1154.0
TLS2_k127_5250607_1 PFAM alpha-L-arabinofuranosidase domain protein K01209 - 3.2.1.55 1.95e-238 745.0
TLS2_k127_5250607_10 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147,K06148 - - 0.00000002045 55.0
TLS2_k127_5250607_2 nitrogen compound transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 511.0
TLS2_k127_5250607_3 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 504.0
TLS2_k127_5250607_4 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K10824 - 3.6.3.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 496.0
TLS2_k127_5250607_5 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 441.0
TLS2_k127_5250607_6 COG3119 Arylsulfatase A and related enzymes K01133 - 3.1.6.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008366 438.0
TLS2_k127_5250607_7 PFAM Binding-protein-dependent transport system inner membrane component K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004914 273.0
TLS2_k127_5250607_8 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003131 272.0
TLS2_k127_5250607_9 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000002317 93.0
TLS2_k127_5251557_0 membrane protein involved in D-alanine export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 551.0
TLS2_k127_5251557_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000006549 245.0
TLS2_k127_5251557_2 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000694 205.0
TLS2_k127_5251557_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000009678 147.0
TLS2_k127_5251557_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000169 136.0
TLS2_k127_5251557_5 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000002203 64.0
TLS2_k127_5254899_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 0.0 1046.0
TLS2_k127_5254899_1 helix_turn_helix, Lux Regulon K03556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 541.0
TLS2_k127_5254899_2 N,N-dimethylaniline monooxygenase activity K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000083 496.0
TLS2_k127_5254899_3 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000001505 244.0
TLS2_k127_5254899_4 - - - - 0.0000000000000000000000000000000000000000000000000000003086 196.0
TLS2_k127_5254899_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000001843 147.0
TLS2_k127_5254899_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000004574 133.0
TLS2_k127_5254899_7 von Willebrand factor (vWF) type A domain - - - 0.00008055 52.0
TLS2_k127_5259870_0 Mandelate racemase muconate lactonizing enzyme K01683 - 4.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000003721 267.0
TLS2_k127_5259870_1 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000003569 92.0
TLS2_k127_5280137_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 539.0
TLS2_k127_5280137_1 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 402.0
TLS2_k127_5280137_10 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000007066 158.0
TLS2_k127_5280137_11 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000002889 75.0
TLS2_k127_5280137_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 336.0
TLS2_k127_5280137_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000001612 265.0
TLS2_k127_5280137_4 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000006295 227.0
TLS2_k127_5280137_5 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000002921 213.0
TLS2_k127_5280137_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000001622 202.0
TLS2_k127_5280137_7 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000009426 183.0
TLS2_k127_5280137_8 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000002685 166.0
TLS2_k127_5280137_9 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000005736 168.0
TLS2_k127_5306279_0 COG COG3119 Arylsulfatase A and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 462.0
TLS2_k127_5306279_1 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001495 279.0
TLS2_k127_5306279_2 mannonate dehydratase activity K01686 - 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000293 238.0
TLS2_k127_5306279_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000001771 113.0
TLS2_k127_5306279_4 solute-binding protein - - - 0.0000000000000000000000005201 119.0
TLS2_k127_5306279_5 - - - - 0.00000136 50.0
TLS2_k127_5345849_0 Alpha amylase, C-terminal all-beta domain K00700 - 2.4.1.18 1.208e-233 737.0
TLS2_k127_5345849_1 dehydratase, large subunit K01699,K06120 - 4.2.1.28,4.2.1.30 4.504e-216 697.0
TLS2_k127_5345849_10 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 352.0
TLS2_k127_5345849_11 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 358.0
TLS2_k127_5345849_12 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 336.0
TLS2_k127_5345849_13 Protein involved in cellulose biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 328.0
TLS2_k127_5345849_14 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain K20022 - 4.2.1.158 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 329.0
TLS2_k127_5345849_15 O-methyltransferase activity K00545 - 2.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 309.0
TLS2_k127_5345849_16 Aldolase/RraA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 304.0
TLS2_k127_5345849_17 Phosphorylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001455 285.0
TLS2_k127_5345849_18 PFAM Glycoside hydrolase, family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007812 294.0
TLS2_k127_5345849_19 Predicted membrane protein (DUF2243) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005527 249.0
TLS2_k127_5345849_2 PFAM Mandelate racemase muconate lactonizing K01706 - 4.2.1.40 2.764e-203 640.0
TLS2_k127_5345849_20 ADP-glyceromanno-heptose 6-epimerase activity K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000009709 197.0
TLS2_k127_5345849_21 FR47-like protein K03829 - - 0.00000000000000000000000000000000000000000000000000007834 192.0
TLS2_k127_5345849_22 2-dehydro-3-deoxyphosphogluconate aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000000000000000000002644 190.0
TLS2_k127_5345849_23 Dehydratase K13919 - 4.2.1.28 0.0000000000000000000000000000000000000000003246 181.0
TLS2_k127_5345849_24 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000006483 167.0
TLS2_k127_5345849_25 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - 0.00000000000000000000000000000006671 127.0
TLS2_k127_5345849_26 Dehydratase small subunit K13920 - 4.2.1.28 0.0000000000000000000000000002381 119.0
TLS2_k127_5345849_27 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000002451 124.0
TLS2_k127_5345849_28 PFAM EamA-like transporter family - - - 0.000000000000000000000007608 112.0
TLS2_k127_5345849_29 very-long-chain-acyl-CoA dehydrogenase activity K01007,K18845 - 2.1.1.179,2.7.9.2 0.00000000000000000000003666 112.0
TLS2_k127_5345849_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 565.0
TLS2_k127_5345849_30 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000008443 91.0
TLS2_k127_5345849_31 - - - - 0.00000000004804 68.0
TLS2_k127_5345849_32 Acetyltransferase (GNAT) family - - - 0.00002093 53.0
TLS2_k127_5345849_4 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 562.0
TLS2_k127_5345849_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 542.0
TLS2_k127_5345849_6 Catalyzes the dehydration of D-mannonate K01686 - 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000826 447.0
TLS2_k127_5345849_7 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 394.0
TLS2_k127_5345849_8 PFAM PfkB domain protein K00874 - 2.7.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 389.0
TLS2_k127_5345849_9 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 348.0
TLS2_k127_5370090_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 5.069e-200 632.0
TLS2_k127_5370090_1 MgtE intracellular N domain K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 348.0
TLS2_k127_5370090_2 PFAM Ion transport protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008674 287.0
TLS2_k127_5370090_3 PFAM RNA-directed DNA polymerase (Reverse transcriptase) K00986 - 2.7.7.49 0.000000000000000000000000000000000000000000000000001567 188.0
TLS2_k127_5370090_4 - - - - 0.000000000000000002568 96.0
TLS2_k127_5370090_5 - - - - 0.0003497 47.0
TLS2_k127_5383039_0 Domain of unknown function(DUF2779) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009639 471.0
TLS2_k127_5383039_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 419.0
TLS2_k127_5383039_10 AAA ATPase domain - - - 0.000000000000000000000004636 118.0
TLS2_k127_5383039_11 acetyltransferase K18816 GO:0003674,GO:0003824,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0034069,GO:0042221,GO:0046677,GO:0047663,GO:0050896 2.3.1.82 0.00000000000001208 80.0
TLS2_k127_5383039_12 transposition, DNA-mediated K02342,K07480 - 2.7.7.7 0.00000000000002433 76.0
TLS2_k127_5383039_13 PFAM extracellular solute-binding protein family 1 K05813 - - 0.0000000000003615 72.0
TLS2_k127_5383039_14 Nodulation protein S (NodS) - - - 0.00000000009662 70.0
TLS2_k127_5383039_15 Bacterial extracellular solute-binding protein K05813 - - 0.00001579 49.0
TLS2_k127_5383039_16 - - - - 0.0003156 53.0
TLS2_k127_5383039_2 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 322.0
TLS2_k127_5383039_3 - K06921 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 329.0
TLS2_k127_5383039_4 transposition, DNA-mediated K02342,K07480 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000007934 246.0
TLS2_k127_5383039_5 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000002075 234.0
TLS2_k127_5383039_6 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000002176 222.0
TLS2_k127_5383039_7 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000007559 194.0
TLS2_k127_5383039_8 Predicted membrane protein (DUF2214) K08983 - - 0.000000000000000000000000000000000002779 147.0
TLS2_k127_5383039_9 Bacterial extracellular solute-binding protein K05813 - - 0.00000000000000000000000002597 111.0
TLS2_k127_5383662_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 0.0 1050.0
TLS2_k127_5383662_1 DNA helicase - - - 2.439e-260 829.0
TLS2_k127_5383662_10 Yip1 domain - - - 0.00000000000000000000000000000003344 134.0
TLS2_k127_5383662_11 pyridoxamine 5'-phosphate K07005 - - 0.0000002415 58.0
TLS2_k127_5383662_2 MlrC C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 587.0
TLS2_k127_5383662_3 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 501.0
TLS2_k127_5383662_4 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 377.0
TLS2_k127_5383662_5 PHP domain protein K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 334.0
TLS2_k127_5383662_6 Putative serine dehydratase domain K18425 - 4.1.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008122 293.0
TLS2_k127_5383662_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007411 265.0
TLS2_k127_5383662_8 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000002388 194.0
TLS2_k127_5383662_9 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000005399 175.0
TLS2_k127_5392252_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1323.0
TLS2_k127_5392252_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 2.566e-289 894.0
TLS2_k127_5392252_2 Rieske [2Fe-2S] domain K02636 - 1.10.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000001135 254.0
TLS2_k127_5392252_3 Cytochrome c K17222 - - 0.0000000000000000000000000000000000000000000000000001008 192.0
TLS2_k127_5394827_0 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 6.812e-307 971.0
TLS2_k127_5394827_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 4.235e-231 724.0
TLS2_k127_5394827_2 4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase K01236 - 3.2.1.141 4.948e-198 635.0
TLS2_k127_5394827_3 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009782 504.0
TLS2_k127_5394827_4 - - - - 0.00000000000000000003912 96.0
TLS2_k127_5397805_0 GMC oxidoreductase K00108 - 1.1.99.1 8.973e-202 643.0
TLS2_k127_5397805_1 ROK family K00886 - 2.7.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 344.0
TLS2_k127_5397805_2 Protein of unknown function (DUF1295) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 306.0
TLS2_k127_5397805_4 PFAM DoxX family protein K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000000000000000000002086 232.0
TLS2_k127_5397805_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000005382 231.0
TLS2_k127_5397805_6 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000001387 215.0
TLS2_k127_5397805_9 - - - - 0.0004168 51.0
TLS2_k127_5404381_0 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000001392 189.0
TLS2_k127_5404381_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000004843 92.0
TLS2_k127_5404381_2 Tetratricopeptide repeat - - - 0.000000000000004409 91.0
TLS2_k127_5404381_3 - - - - 0.00000000007239 73.0
TLS2_k127_5413425_0 oxidation-reduction process - - - 0.00000000000000000000000000000000000000000000000000000000004623 215.0
TLS2_k127_5413425_1 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000419 213.0
TLS2_k127_5413425_2 reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000004742 199.0
TLS2_k127_5415439_0 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 478.0
TLS2_k127_5415439_1 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 303.0
TLS2_k127_5415439_2 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000003123 183.0
TLS2_k127_5415439_3 Haloacid dehalogenase, type II K01560 - 3.8.1.2 0.000000000000000000000000000000000000000002088 164.0
TLS2_k127_5415439_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000001454 127.0
TLS2_k127_5415439_5 Trehalose synthase - - - 0.0000000000000000001147 90.0
TLS2_k127_5415439_6 Chitobiase/beta-hexosaminidase C-terminal domain - - - 0.0003387 54.0
TLS2_k127_5415439_7 Fibronectin type 3 domain - - - 0.000467 55.0
TLS2_k127_5415439_8 Cytoplasmic, score 8.87 - - - 0.0005841 49.0
TLS2_k127_5445163_0 tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 572.0
TLS2_k127_5445163_1 GHMP kinases N terminal domain K01597 - 4.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 360.0
TLS2_k127_5445163_3 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.00000000000000000000000000001116 119.0
TLS2_k127_5521832_0 Belongs to the IlvD Edd family - - - 1.394e-255 799.0
TLS2_k127_5521832_1 Polysaccharide biosynthesis C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 578.0
TLS2_k127_5521832_10 - - - - 0.000000000000000003919 94.0
TLS2_k127_5521832_11 dockerin type I repeat-containing domain protein - - - 0.0003724 55.0
TLS2_k127_5521832_2 PFAM Glucose Sorbosone dehydrogenase K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 579.0
TLS2_k127_5521832_3 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 429.0
TLS2_k127_5521832_4 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465,K01466 - 3.5.2.3,3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 335.0
TLS2_k127_5521832_5 PFAM aminotransferase, class I K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 293.0
TLS2_k127_5521832_6 DinB family - - - 0.00000000000000000000000000000000000000000000000000000002489 200.0
TLS2_k127_5521832_7 transcriptional activator domain - - - 0.00000000000000000000000000000000000009822 154.0
TLS2_k127_5521832_8 Isochorismatase family - - - 0.0000000000000000000000000000553 124.0
TLS2_k127_5522200_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1230.0
TLS2_k127_5522200_1 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003244 267.0
TLS2_k127_5522200_2 Belongs to the 'phage' integrase family K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000001223 237.0
TLS2_k127_5522200_3 Protein of unknown function (DUF2442) - - - 0.0000000000000000000000000001251 117.0
TLS2_k127_5522200_4 Domain of unknown function (DUF4160) - - - 0.00000000000000000004951 91.0
TLS2_k127_5522200_5 PFAM restriction modification system DNA specificity domain K01154 - 3.1.21.3 0.0000008214 53.0
TLS2_k127_5524586_0 PFAM cytochrome c oxidase, subunit I K02274 - 1.9.3.1 1.677e-262 818.0
TLS2_k127_5524586_1 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000935 213.0
TLS2_k127_5524586_2 SCO1/SenC K07152 - - 0.000000000000000000000000000000000000000001087 167.0
TLS2_k127_5524586_3 signal sequence binding K07152 - - 0.00000000000000000000000002716 110.0
TLS2_k127_5525412_0 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 2.482e-269 842.0
TLS2_k127_5525412_1 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 - 1.1.1.42 1.003e-232 722.0
TLS2_k127_5525412_2 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000001879 187.0
TLS2_k127_5553742_0 Mandelate racemase muconate lactonizing enzyme, N-terminal domain K01683,K01684 - 4.2.1.5,4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009671 430.0
TLS2_k127_5553742_1 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 389.0
TLS2_k127_5553742_10 YtkA-like - - - 0.0000000001799 72.0
TLS2_k127_5553742_2 Bacterial periplasmic substrate-binding proteins K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002534 251.0
TLS2_k127_5553742_3 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000000000000000000000000000000000000000000000008473 226.0
TLS2_k127_5553742_4 [2Fe-2S] binding domain K18029 - 1.17.2.1 0.0000000000000000000000000000000000000000000000002069 181.0
TLS2_k127_5553742_5 PFAM PIN domain - - - 0.000000000000000000000000000000001001 133.0
TLS2_k127_5553742_6 Copper chaperone PCu(A)C K09796 - - 0.0000000000000000000000002959 117.0
TLS2_k127_5553742_7 DinB family - - - 0.0000000000000000000000007745 111.0
TLS2_k127_5553742_8 Molybdopterin-binding domain of aldehyde dehydrogenase - - - 0.0000000000000000000002867 99.0
TLS2_k127_5553742_9 positive regulation of growth - - - 0.0000000000000000009142 90.0
TLS2_k127_55776_0 PFAM carbohydrate kinase K00854 - 2.7.1.17 6.876e-213 672.0
TLS2_k127_55776_1 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 358.0
TLS2_k127_55776_2 ErfK ybiS ycfS ynhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 290.0
TLS2_k127_55776_3 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.0000000000000000000000000000000000000000000003052 176.0
TLS2_k127_55776_4 - - - - 0.000000001018 66.0
TLS2_k127_5622455_0 PFAM AAA ATPase central domain protein K07478 - - 0.0 1027.0
TLS2_k127_5622455_1 carbohydrate transport K17241 - - 9.198e-226 707.0
TLS2_k127_5622455_2 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17242,K17316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 503.0
TLS2_k127_5622455_3 glycerophosphodiester transmembrane transport K17243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 414.0
TLS2_k127_5625722_1 Iron-containing alcohol dehydrogenase K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 448.0
TLS2_k127_5625722_10 acetyltransferase K17840 - 2.3.1.59 0.000000002481 65.0
TLS2_k127_5625722_2 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002439 274.0
TLS2_k127_5625722_3 PFAM Translin K07477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004196 271.0
TLS2_k127_5625722_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000002754 273.0
TLS2_k127_5625722_5 ABC-type sugar transport system, permease component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001462 252.0
TLS2_k127_5625722_6 Extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000001248 203.0
TLS2_k127_5625722_7 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000004618 151.0
TLS2_k127_5625722_8 xylulokinase activity K00848,K00851,K00854 - 2.7.1.12,2.7.1.17,2.7.1.5 0.000000000000000000000000005588 113.0
TLS2_k127_5630092_0 PFAM transferase hexapeptide repeat containing protein K16881 - 2.7.7.13,5.4.2.8 3.776e-284 885.0
TLS2_k127_5630092_1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008946 342.0
TLS2_k127_5630092_2 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000004932 119.0
TLS2_k127_5630092_3 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01739 - 2.5.1.48 0.0000000000000000000806 89.0
TLS2_k127_5636252_0 Domain of unknown function (DUF4132) - - - 4.285e-279 882.0
TLS2_k127_5636252_1 Dipeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 578.0
TLS2_k127_5636252_2 Phosphotriesterase family K07048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 426.0
TLS2_k127_5636252_3 - - - - 0.00000000000000000000000000000000000008932 146.0
TLS2_k127_5645091_0 beta-galactosidase activity K01195 - 3.2.1.31 4.727e-281 879.0
TLS2_k127_5645091_1 PFAM transglutaminase domain protein - - - 4.716e-245 783.0
TLS2_k127_5645091_10 - - - - 0.000000000000000000000000000000000000000000005326 165.0
TLS2_k127_5645091_11 chromosome segregation K03497 - - 0.0000000000000000000000000000002885 135.0
TLS2_k127_5645091_12 Bacterial PH domain - - - 0.000000000000000000000000001026 120.0
TLS2_k127_5645091_13 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K01185,K02395,K19220,K19223 GO:0005575,GO:0005576 3.2.1.17 0.0000000000000003955 93.0
TLS2_k127_5645091_14 PFAM DSBA oxidoreductase - - - 0.00000000000002999 77.0
TLS2_k127_5645091_15 PFAM Spore germination protein-like Gmad2, bacteria - - - 0.000003104 60.0
TLS2_k127_5645091_16 Group 1 family - - - 0.0006898 50.0
TLS2_k127_5645091_2 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 587.0
TLS2_k127_5645091_3 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 325.0
TLS2_k127_5645091_4 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001182 280.0
TLS2_k127_5645091_5 protein (ATP-grasp superfamily) K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002616 279.0
TLS2_k127_5645091_7 ANKH inorganic pyrophosphate transport regulator - GO:0001501,GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0007275,GO:0007610,GO:0007626,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019867,GO:0022804,GO:0022857,GO:0030278,GO:0030500,GO:0030504,GO:0030505,GO:0031224,GO:0031226,GO:0032501,GO:0032502,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0048731,GO:0048856,GO:0050789,GO:0050793,GO:0051179,GO:0051234,GO:0051239,GO:0055085,GO:0065007,GO:0070167,GO:0071944,GO:0098656,GO:2000026 - 0.00000000000000000000000000000000000000000000000000000000000000000000000003489 267.0
TLS2_k127_5645091_8 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin K14645,K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003882 268.0
TLS2_k127_5645091_9 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001 248.0
TLS2_k127_5653660_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 376.0
TLS2_k127_5653660_2 GDP-mannose mannosyl hydrolase activity K03574,K13669 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000002259 242.0
TLS2_k127_5653660_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000008424 235.0
TLS2_k127_5653660_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000199 204.0
TLS2_k127_5653660_5 Peptide nickel ABC transporter, substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000005345 202.0
TLS2_k127_5716788_0 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 446.0
TLS2_k127_5716788_1 PFAM Integral membrane protein TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 396.0
TLS2_k127_5716788_2 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 378.0
TLS2_k127_5716788_3 Protein of unknown function (DUF1706) - - - 0.000000000000000000000000000000003255 134.0
TLS2_k127_5716788_4 Hep Hag repeat protein - - - 0.0000005591 62.0
TLS2_k127_5720516_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2270.0
TLS2_k127_5720516_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2093.0
TLS2_k127_5720516_10 hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 295.0
TLS2_k127_5720516_11 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000008507 261.0
TLS2_k127_5720516_12 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005355 263.0
TLS2_k127_5720516_13 Transcriptional regulator K05799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000852 249.0
TLS2_k127_5720516_14 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000001117 229.0
TLS2_k127_5720516_15 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000000000000000000005407 207.0
TLS2_k127_5720516_16 SMART helix-turn-helix domain protein K15539 - - 0.000000000000000000000000000000000000000000000004323 190.0
TLS2_k127_5720516_17 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000003709 158.0
TLS2_k127_5720516_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009034 549.0
TLS2_k127_5720516_3 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 556.0
TLS2_k127_5720516_4 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 393.0
TLS2_k127_5720516_5 transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 347.0
TLS2_k127_5720516_6 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 342.0
TLS2_k127_5720516_7 ABC-type polysaccharide transport system permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 335.0
TLS2_k127_5720516_8 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 323.0
TLS2_k127_5720516_9 Aldo/keto reductase family K00064 - 1.1.1.122 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 304.0
TLS2_k127_5721975_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 - 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 288.0
TLS2_k127_5721975_1 COGs COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005044 268.0
TLS2_k127_5721975_2 sirohydrochlorin cobaltochelatase activity K02304,K03794,K03795 - 1.3.1.76,4.99.1.3,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000001349 215.0
TLS2_k127_5721975_3 tetraacyldisaccharide 4'-kinase activity - - - 0.000000000000000000000000000000000000000000001293 171.0
TLS2_k127_5721975_4 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02304,K13541 - 1.3.1.76,2.1.1.131,3.7.1.12,4.99.1.4 0.0000000000000000000000000000000000002957 146.0
TLS2_k127_5730995_0 Vitamin B12 dependent methionine synthase activation K00548 - 2.1.1.13 6.688e-285 886.0
TLS2_k127_5730995_1 Transcriptional regulatory protein, C terminal K02483,K07658 - - 0.000000000000000000000000000000000000000000000000000000000000000000664 236.0
TLS2_k127_5730995_2 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000008538 205.0
TLS2_k127_5730995_3 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000006056 81.0
TLS2_k127_5739948_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005874 405.0
TLS2_k127_5739948_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 382.0
TLS2_k127_5739948_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 287.0
TLS2_k127_5739948_3 thiolester hydrolase activity K01055,K02170 - 3.1.1.24,3.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002413 282.0
TLS2_k127_5739948_4 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000003683 247.0
TLS2_k127_5739948_5 Peptidase family M50 K06212,K06402 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000004123 249.0
TLS2_k127_5739948_6 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000002817 242.0
TLS2_k127_5772603_0 Phage late control gene D protein (GPD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000606 387.0
TLS2_k127_5772603_1 Baseplate J-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 344.0
TLS2_k127_5772603_2 PFAM GPW gp25 family protein K06903 - - 0.000000000000000000000000000000000000006865 149.0
TLS2_k127_5772603_3 LysM domain - - - 0.00000000000000000000000000000000000009188 150.0
TLS2_k127_5772603_4 PAAR repeat-containing protein - - - 0.000000000000000000000003112 105.0
TLS2_k127_5772603_5 T4-like virus tail tube protein gp19 - - - 0.00000000000000007252 85.0
TLS2_k127_5777164_0 MATE efflux family protein K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 481.0
TLS2_k127_5777164_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 407.0
TLS2_k127_5777164_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006614 386.0
TLS2_k127_5777164_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 357.0
TLS2_k127_5777164_4 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000003023 136.0
TLS2_k127_5783915_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 2.667e-206 650.0
TLS2_k127_5783915_1 CO dehydrogenase flavoprotein C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000855 581.0
TLS2_k127_5783915_10 PFAM Phospholipid glycerol acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000003492 211.0
TLS2_k127_5783915_11 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000004637 207.0
TLS2_k127_5783915_12 cyclopropane-fatty-acyl-phospholipid synthase K00574,K03466 - 2.1.1.79 0.00000000000000000000000000000000000000000000001542 177.0
TLS2_k127_5783915_13 transcriptional activator domain - - - 0.00000000000000000000000000000000000000000006111 185.0
TLS2_k127_5783915_14 - - - - 0.0000000000000000000000000000000000000131 147.0
TLS2_k127_5783915_15 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.000000000000000000000000000000000001455 146.0
TLS2_k127_5783915_16 Belongs to the carbohydrate kinase PfkB family K00882 - 2.7.1.56 0.0000000000000000000000000003204 126.0
TLS2_k127_5783915_17 Protein of unknown function (DUF2283) - - - 0.000000000000000000000003106 103.0
TLS2_k127_5783915_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000007288 95.0
TLS2_k127_5783915_2 Fibronectin-binding A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009599 554.0
TLS2_k127_5783915_3 PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 496.0
TLS2_k127_5783915_4 Mandelate racemase muconate lactonizing enzyme K18983 - 5.5.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 467.0
TLS2_k127_5783915_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 389.0
TLS2_k127_5783915_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 334.0
TLS2_k127_5783915_7 Protein of unknown function (DUF3891) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002168 284.0
TLS2_k127_5783915_8 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000677 252.0
TLS2_k127_5783915_9 SPTR Cell surface protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002473 240.0
TLS2_k127_578895_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 4.314e-302 936.0
TLS2_k127_578895_1 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000000000000000000000000000004843 145.0
TLS2_k127_578895_2 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.0000000000000000000000000000004352 133.0
TLS2_k127_578895_3 Anti-sigma-K factor rskA - - - 0.0002232 52.0
TLS2_k127_5790754_0 P-type ATPase K17686 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 3.6.3.54 3.487e-255 811.0
TLS2_k127_5790754_1 Protein of unknown function (DUF418) K07148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009862 437.0
TLS2_k127_5790754_10 - - - - 0.0000000000000008676 81.0
TLS2_k127_5790754_11 mercury ion transmembrane transporter activity K07213 - - 0.0000000000002328 72.0
TLS2_k127_5790754_12 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.000000004088 63.0
TLS2_k127_5790754_2 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 327.0
TLS2_k127_5790754_3 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001543 267.0
TLS2_k127_5790754_4 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000009668 214.0
TLS2_k127_5790754_5 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000002397 124.0
TLS2_k127_5790754_6 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000581 123.0
TLS2_k127_5790754_7 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - 0.0000000000000000000000000008274 114.0
TLS2_k127_5790754_8 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000009148 111.0
TLS2_k127_5790754_9 carboxylic ester hydrolase activity - - - 0.000000000000000000003302 93.0
TLS2_k127_5798140_0 pyrroloquinoline quinone binding - - - 2.769e-314 987.0
TLS2_k127_5798140_1 COGs COG3533 conserved K09955 - - 3.813e-293 914.0
TLS2_k127_5798140_10 COG0665 Glycine D-amino acid oxidases (deaminating) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 390.0
TLS2_k127_5798140_11 folic acid synthesis protein K13939,K13941 GO:0003674,GO:0003824,GO:0003848,GO:0004150,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016772,GO:0016778,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019752,GO:0031967,GO:0031975,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3,4.1.2.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 361.0
TLS2_k127_5798140_12 helix_turn _helix lactose operon repressor K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 349.0
TLS2_k127_5798140_13 polysaccharide catabolic process K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 346.0
TLS2_k127_5798140_14 cytochrome P450 K15629 - 1.11.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 317.0
TLS2_k127_5798140_15 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 298.0
TLS2_k127_5798140_16 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 296.0
TLS2_k127_5798140_17 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000248 286.0
TLS2_k127_5798140_18 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002006 261.0
TLS2_k127_5798140_19 Protein of unknown function (DUF541) K09807 - - 0.00000000000000000000000000000000000000000000000000000000000007068 222.0
TLS2_k127_5798140_2 PFAM NADH flavin oxidoreductase NADH oxidase - - - 1.319e-221 695.0
TLS2_k127_5798140_20 aldo keto reductase K00064 - 1.1.1.122 0.0000000000000000000000000000000000000000000008288 178.0
TLS2_k127_5798140_21 Transcriptional regulator - - - 0.00000000000000000000000000000000001501 141.0
TLS2_k127_5798140_22 TAP-like protein - - - 0.00000000000000000000000000000000005659 139.0
TLS2_k127_5798140_23 Putative cyclase K00036,K07130 - 1.1.1.363,1.1.1.49,3.5.1.9 0.0000000000000000000000000000000001424 140.0
TLS2_k127_5798140_24 Bacterial regulatory proteins, tetR family K16137 - - 0.000000000000000000000000006225 118.0
TLS2_k127_5798140_25 Flavin and coenzyme A sequestration protein dodecin K09165 - - 0.000000000000000000000002546 104.0
TLS2_k127_5798140_26 carbohydrate transport K02027 - - 0.00000000000000000169 88.0
TLS2_k127_5798140_27 MerR, DNA binding - - - 0.0000000000000007994 87.0
TLS2_k127_5798140_28 protein secretion K03116 - - 0.00000000002462 67.0
TLS2_k127_5798140_29 protein secretion K03116,K03117 - - 0.0000000007552 59.0
TLS2_k127_5798140_3 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.226e-211 675.0
TLS2_k127_5798140_30 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000945 43.0
TLS2_k127_5798140_4 - - - - 4.291e-210 669.0
TLS2_k127_5798140_5 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006906 482.0
TLS2_k127_5798140_6 PFAM peptidase S15 K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 475.0
TLS2_k127_5798140_7 PFAM Glycosyl Hydrolase Family 88 K18581 - 3.2.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 455.0
TLS2_k127_5798140_8 PFAM Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 410.0
TLS2_k127_5798140_9 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 411.0
TLS2_k127_5807268_0 Belongs to the peptidase S16 family - - - 1.25e-308 964.0
TLS2_k127_5807268_1 extracellular solute-binding protein, family 3 K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001395 255.0
TLS2_k127_5815863_0 Belongs to the mandelate racemase muconate lactonizing enzyme family K01684 - 4.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009754 519.0
TLS2_k127_5815863_1 PFAM MscS Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 443.0
TLS2_k127_5815863_2 Lamin Tail Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 349.0
TLS2_k127_5815863_3 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002666 263.0
TLS2_k127_5815863_4 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002602 264.0
TLS2_k127_5815863_5 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000864 258.0
TLS2_k127_5815863_6 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001111 259.0
TLS2_k127_5815863_7 proline dipeptidase activity K08688 - 3.5.3.3 0.000000000000000000000000000000000000000000000000000000000000000001555 242.0
TLS2_k127_5815863_8 Lamin Tail Domain - - - 0.00000000001011 79.0
TLS2_k127_5834381_0 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000005543 241.0
TLS2_k127_5834381_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000005231 153.0
TLS2_k127_5834381_2 Glycosyl transferase, family 2 K13500 - 2.4.1.175,2.4.1.226 0.00000000000000000000000000000004756 140.0
TLS2_k127_5834381_3 Glycosyltransferase like family 2 K07011,K20444 - - 0.0000000000000000000000000004043 133.0
TLS2_k127_5834381_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000001388 95.0
TLS2_k127_5834381_5 TIGRFAM autotransporter-associated beta strand repeat protein - - - 0.00000000005209 76.0
TLS2_k127_5840320_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 6e-323 998.0
TLS2_k127_5840320_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 9.341e-224 706.0
TLS2_k127_5840320_10 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.0000000000000000000000000000000000000000000000000000000000000002028 227.0
TLS2_k127_5840320_11 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000000000000000008704 147.0
TLS2_k127_5840320_12 PilT protein domain protein - - - 0.00000001332 57.0
TLS2_k127_5840320_2 PFAM NAD-dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 556.0
TLS2_k127_5840320_3 NB-ARC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 416.0
TLS2_k127_5840320_4 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009294 341.0
TLS2_k127_5840320_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 298.0
TLS2_k127_5840320_6 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000921 299.0
TLS2_k127_5840320_7 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001213 276.0
TLS2_k127_5840320_8 4-phosphoerythronate dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001163 236.0
TLS2_k127_5840320_9 AAA domain K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000008911 236.0
TLS2_k127_5845911_0 PFAM ABC transporter related K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 413.0
TLS2_k127_5845911_1 PFAM ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 321.0
TLS2_k127_5845911_2 Glycosyl hydrolase catalytic core - - - 0.000000000000000000000000000000000000005197 154.0
TLS2_k127_5845911_3 Glycosyltransferase like family 2 K07011,K20444 - - 0.00000000000002552 81.0
TLS2_k127_5849153_0 Belongs to the aldehyde dehydrogenase family K22187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 491.0
TLS2_k127_5849153_1 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 416.0
TLS2_k127_5849153_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007384 389.0
TLS2_k127_5849153_3 mandelate racemase muconate lactonizing K01684,K08323 - 4.2.1.6,4.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 355.0
TLS2_k127_5849153_4 Fumarylacetoacetate (FAA) hydrolase family K14259 - 4.2.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 347.0
TLS2_k127_5849153_5 Aldolase/RraA K10218 - 4.1.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 292.0
TLS2_k127_5849153_6 - - - - 0.000000000000000000000000000000000000000000000000000009 200.0
TLS2_k127_5849153_7 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000000000000000000000000449 181.0
TLS2_k127_5849153_8 Transglutaminase/protease-like homologues K01406 - 3.4.24.40 0.0000000000000003768 87.0
TLS2_k127_5849153_9 - - - - 0.0000001158 55.0
TLS2_k127_58567_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 608.0
TLS2_k127_58567_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 591.0
TLS2_k127_58567_10 transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009014 263.0
TLS2_k127_58567_11 helix_turn_helix isocitrate lyase regulation K13641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002487 257.0
TLS2_k127_58567_12 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000003274 217.0
TLS2_k127_58567_13 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000002764 184.0
TLS2_k127_58567_14 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000006041 164.0
TLS2_k127_58567_15 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000002123 146.0
TLS2_k127_58567_2 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 531.0
TLS2_k127_58567_3 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 487.0
TLS2_k127_58567_4 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 446.0
TLS2_k127_58567_5 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 341.0
TLS2_k127_58567_6 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 297.0
TLS2_k127_58567_7 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002159 291.0
TLS2_k127_58567_8 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001112 279.0
TLS2_k127_58567_9 MlrC C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005739 274.0
TLS2_k127_5860282_0 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 561.0
TLS2_k127_5860282_1 PFAM Glycosyl transferase, group 1 K13057 - 2.4.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 500.0
TLS2_k127_5860282_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 336.0
TLS2_k127_5860282_3 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006041 353.0
TLS2_k127_5860282_4 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000004881 216.0
TLS2_k127_5860282_5 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.000000000000000000000000000000000000000000000000000001401 193.0
TLS2_k127_5866383_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 551.0
TLS2_k127_5866383_1 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 520.0
TLS2_k127_5866383_2 Carbamoyl-phosphate synthetase large chain domain protein K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000992 491.0
TLS2_k127_5866383_3 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 452.0
TLS2_k127_5866383_4 Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 329.0
TLS2_k127_5866383_5 mandelate racemase muconate lactonizing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009953 298.0
TLS2_k127_5866383_6 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000086 281.0
TLS2_k127_5866383_7 - - - - 0.0000000001593 73.0
TLS2_k127_5903252_0 Belongs to the ABC transporter superfamily K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 299.0
TLS2_k127_5903252_1 ABC transporter (Permease) K02026 - - 0.0000000000000000000000000000000000000000000000000000001062 206.0
TLS2_k127_5903252_2 PFAM Binding-protein-dependent transport system inner membrane component K02025,K10118 - - 0.00000000000000000000000000000000000000000000000000002804 198.0
TLS2_k127_5912433_0 Domain of unknown function (DUF348) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 509.0
TLS2_k127_5912433_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 514.0
TLS2_k127_5912433_2 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 441.0
TLS2_k127_5912433_3 carboxylic ester hydrolase activity K03928 - 3.1.1.1 0.0000000000000000000000000000000000000003478 160.0
TLS2_k127_5917736_0 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 415.0
TLS2_k127_5917736_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 389.0
TLS2_k127_5917736_2 Belongs to the ABC transporter superfamily K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007677 390.0
TLS2_k127_5925379_0 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 6.616e-257 803.0
TLS2_k127_5925379_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 575.0
TLS2_k127_5925379_2 PFAM NADH-Ubiquinone oxidoreductase (complex I), chain 5 L domain protein K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 299.0
TLS2_k127_5930244_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 9.094e-290 935.0
TLS2_k127_5930244_1 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 605.0
TLS2_k127_5930244_10 - - - - 0.0000000000000001079 83.0
TLS2_k127_5930244_11 nucleotidyltransferase activity - - - 0.00000000002508 74.0
TLS2_k127_5930244_12 Metallo-beta-lactamase superfamily - - - 0.000001984 53.0
TLS2_k127_5930244_13 homoserine kinase activity K02204 - 2.7.1.39 0.000007225 49.0
TLS2_k127_5930244_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 578.0
TLS2_k127_5930244_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 372.0
TLS2_k127_5930244_4 PFAM binding-protein-dependent transport systems inner membrane component K02050 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 305.0
TLS2_k127_5930244_5 ErfK ybiS ycfS ynhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003743 251.0
TLS2_k127_5930244_6 PFAM DSBA oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000003515 221.0
TLS2_k127_5930244_7 sigma-70 region 2 domain protein K03088 - - 0.000000000000000000000000000000000000000000000000006003 189.0
TLS2_k127_5930244_8 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000001145 181.0
TLS2_k127_5930244_9 - - - - 0.00000000000000000000000000000000000000001701 162.0
TLS2_k127_594804_0 gluconolactonase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009691 484.0
TLS2_k127_594804_1 PFAM peptidase S1 and S6, chymotrypsin Hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 310.0
TLS2_k127_594804_2 PFAM Cyclic nucleotide-binding K10914,K21564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 298.0
TLS2_k127_594804_3 Protein of unknown function (DUF3307) - - - 0.000000000000000000000000107 113.0
TLS2_k127_594804_4 invertase K03332 - 3.2.1.80 0.000006696 52.0
TLS2_k127_595563_0 Membrane - - - 6.407e-261 829.0
TLS2_k127_595563_1 PFAM O-antigen polymerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 593.0
TLS2_k127_595563_2 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 562.0
TLS2_k127_595563_3 Glycosyl transferase, family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 354.0
TLS2_k127_595563_4 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 310.0
TLS2_k127_595563_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001364 228.0
TLS2_k127_595563_6 Bacterial membrane protein YfhO - - - 0.0000000000000000000000000000000000000000000000000000000001783 220.0
TLS2_k127_5966913_0 Coenzyme A transferase K01026,K19709 GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016043,GO:0016740,GO:0016782,GO:0019752,GO:0022607,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840 2.8.3.1,2.8.3.8 6.321e-213 674.0
TLS2_k127_5966913_1 RNA ligase activity K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 577.0
TLS2_k127_5966913_10 carbohydrate transport K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005499 276.0
TLS2_k127_5966913_11 COG1175 ABC-type sugar transport systems, permease components K17316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000171 266.0
TLS2_k127_5966913_12 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000555 263.0
TLS2_k127_5966913_13 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004051 244.0
TLS2_k127_5966913_14 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000005846 198.0
TLS2_k127_5966913_15 Belongs to the enoyl-CoA hydratase isomerase family K01715,K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000001241 179.0
TLS2_k127_5966913_16 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000004641 164.0
TLS2_k127_5966913_17 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000006937 102.0
TLS2_k127_5966913_18 glyoxalase III activity - - - 0.00000000000000000002022 97.0
TLS2_k127_5966913_19 solute-binding protein K05813 - - 0.00000000000000000004668 104.0
TLS2_k127_5966913_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 467.0
TLS2_k127_5966913_20 hyperosmotic response K04065 - - 0.0000007275 61.0
TLS2_k127_5966913_3 carbohydrate transport K17315 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 404.0
TLS2_k127_5966913_4 Malate/L-lactate dehydrogenase K00073 - 1.1.1.350 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 340.0
TLS2_k127_5966913_5 PFAM binding-protein-dependent transport systems inner membrane component K17317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 335.0
TLS2_k127_5966913_6 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K13075 - 3.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 321.0
TLS2_k127_5966913_7 ABC transporter permease K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 298.0
TLS2_k127_5966913_9 ABC transporter (Permease K02025,K15771 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002106 280.0
TLS2_k127_5981816_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 1e-323 1007.0
TLS2_k127_5981816_1 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 6.143e-240 749.0
TLS2_k127_5981816_10 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 317.0
TLS2_k127_5981816_11 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008252 321.0
TLS2_k127_5981816_12 phosphatase activity K07025,K20866 - 3.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 288.0
TLS2_k127_5981816_13 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.00000000000000000000000000000000000000000000000000000000000005488 220.0
TLS2_k127_5981816_14 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000006036 222.0
TLS2_k127_5981816_15 Domain of unknown function (DUF4870) - - - 0.000000000000000000000000000000000000000000000003774 183.0
TLS2_k127_5981816_16 Protein of unknown function (DUF2089) - - - 0.00000000000000000000000000000000000000000003284 164.0
TLS2_k127_5981816_17 - - - - 0.000000000000000000000000000000000000001102 165.0
TLS2_k127_5981816_18 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000001304 149.0
TLS2_k127_5981816_19 - - - - 0.000000000000001082 83.0
TLS2_k127_5981816_2 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 1.393e-226 709.0
TLS2_k127_5981816_3 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 6.303e-224 702.0
TLS2_k127_5981816_4 translation initiation factor activity K08307,K19140 - - 4.616e-203 655.0
TLS2_k127_5981816_5 ergothioneine biosynthetic process K01919,K06048 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 494.0
TLS2_k127_5981816_6 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000726 437.0
TLS2_k127_5981816_7 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 421.0
TLS2_k127_5981816_8 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 385.0
TLS2_k127_5981816_9 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 383.0
TLS2_k127_5983061_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1274.0
TLS2_k127_5983061_1 PFAM CoA-binding domain protein K01905,K09181,K22224 - 6.2.1.13 0.0 1268.0
TLS2_k127_5983061_10 Transposase - - - 0.00007494 46.0
TLS2_k127_5983061_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 5.311e-262 813.0
TLS2_k127_5983061_3 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 452.0
TLS2_k127_5983061_4 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 439.0
TLS2_k127_5983061_5 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 387.0
TLS2_k127_5983061_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 353.0
TLS2_k127_5983061_7 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000006676 222.0
TLS2_k127_5983061_8 PFAM NADPH-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000001371 175.0
TLS2_k127_5983061_9 acetyltransferase K03827 - - 0.0000000000000000000000000000000000000000001179 165.0
TLS2_k127_6053326_0 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003413 269.0
TLS2_k127_6053326_1 inositol 2-dehydrogenase activity K00010,K03810 - 1.1.1.18,1.1.1.369 0.00000000000000000000000000000000000000000000000000000000001936 218.0
TLS2_k127_6053326_2 membrane - - - 0.00000000000000000000000000000000000001032 150.0
TLS2_k127_6053326_3 HTH-like domain K07497 - - 0.000000000000000000000000000000001494 132.0
TLS2_k127_6053326_4 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000007003 117.0
TLS2_k127_6053326_5 transposition K07497 - - 0.0000000005511 60.0
TLS2_k127_6062170_0 Radical_SAM C-terminal domain K07739 - 2.3.1.48 2.257e-268 835.0
TLS2_k127_6062170_1 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000000000000000000001099 112.0
TLS2_k127_6062170_2 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000216 91.0
TLS2_k127_6062170_3 - - - - 0.0000001672 61.0
TLS2_k127_6063021_0 - - - - 1.038e-271 856.0
TLS2_k127_6063021_1 bacterial-type flagellum-dependent cell motility - - - 2.482e-230 725.0
TLS2_k127_6063021_10 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000001148 194.0
TLS2_k127_6063021_11 Malate/L-lactate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000006362 194.0
TLS2_k127_6063021_12 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000009823 194.0
TLS2_k127_6063021_13 AAA domain K01939 - 6.3.4.4 0.000000000000000000000000000000000000000009022 160.0
TLS2_k127_6063021_14 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000628 147.0
TLS2_k127_6063021_15 DNA-binding transcription factor activity - - - 0.000000000000000000000000000001574 123.0
TLS2_k127_6063021_16 triphosphatase activity - - - 0.00000000000000000000000003328 114.0
TLS2_k127_6063021_17 Protein of unknown function (DUF2905) - - - 0.0000000000000006124 79.0
TLS2_k127_6063021_18 Protein conserved in bacteria - - - 0.000000000003623 81.0
TLS2_k127_6063021_19 ADP binding - - - 0.00004956 48.0
TLS2_k127_6063021_2 melibiose metabolic process K01222,K07406 - 3.2.1.22,3.2.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 462.0
TLS2_k127_6063021_20 Protein conserved in bacteria - - - 0.0002777 55.0
TLS2_k127_6063021_3 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 317.0
TLS2_k127_6063021_4 Predicted permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 301.0
TLS2_k127_6063021_5 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002472 274.0
TLS2_k127_6063021_6 DoxX K15977,K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000824 267.0
TLS2_k127_6063021_7 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002439 295.0
TLS2_k127_6063021_8 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000000000000000000000004238 242.0
TLS2_k127_6063021_9 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000000000000000000000002232 231.0
TLS2_k127_6063563_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000005761 137.0
TLS2_k127_6063563_1 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000002043 126.0
TLS2_k127_6063563_2 Baseplate J-like protein - - - 0.000000000000000000000009115 110.0
TLS2_k127_6063563_3 Phage tail protein (Tail_P2_I) - - - 0.0000000000000000000001168 111.0
TLS2_k127_6063563_4 Forkhead associated domain - - - 0.000000000000000001239 102.0
TLS2_k127_6063563_5 von Willebrand factor (vWF) type A domain - - - 0.00000000009753 76.0
TLS2_k127_6072239_0 Binding-protein-dependent transport systems inner membrane component K10202 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 330.0
TLS2_k127_6072239_1 Binding-protein-dependent transport system inner membrane component K10201 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002554 276.0
TLS2_k127_6072239_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000002253 166.0
TLS2_k127_6072239_3 Exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000005372 144.0
TLS2_k127_6072239_4 nUDIX hydrolase K01515,K01518,K01814 - 3.6.1.13,3.6.1.17,5.3.1.16 0.000000000000000000000000000000005083 132.0
TLS2_k127_6072239_5 Class ii aldolase K01628,K18847 - 2.2.1.8,4.1.2.17 0.000000000000000000002201 109.0
TLS2_k127_6072239_6 Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source - - - 0.000000001171 64.0
TLS2_k127_608976_0 Sulfatase - - - 1.05e-208 658.0
TLS2_k127_608976_1 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 360.0
TLS2_k127_608976_2 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 301.0
TLS2_k127_608976_3 DinB family - - - 0.000000000000000000000000000000000000000000000000000000000000002797 220.0
TLS2_k127_608976_4 PFAM extracellular solute-binding protein family 1 K02027,K10188 - - 0.0000000000000000000000000000000000000000000000002748 194.0
TLS2_k127_608976_5 Polymorphic membrane protein, Chlamydia - - - 0.000000000005685 80.0
TLS2_k127_6091858_0 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 404.0
TLS2_k127_6091858_1 Domain of unknown function (DUF4432) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 377.0
TLS2_k127_6091858_10 oxidation-reduction process K09022 - 3.5.99.10 0.0000000000000000000000000000000502 130.0
TLS2_k127_6091858_11 PFAM extracellular solute-binding protein family 1 K02027,K10188 - - 0.0000000207 68.0
TLS2_k127_6091858_2 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 347.0
TLS2_k127_6091858_3 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005007 330.0
TLS2_k127_6091858_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 299.0
TLS2_k127_6091858_5 Alcohol dehydrogenase GroES-like domain K00008,K08322 GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.14,1.1.1.380 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 299.0
TLS2_k127_6091858_6 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000003113 232.0
TLS2_k127_6091858_7 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000003601 234.0
TLS2_k127_6091858_8 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000004579 205.0
TLS2_k127_6091858_9 amidohydrolase K01845,K07100 - 5.4.3.8 0.0000000000000000000000000000000000000000000001467 179.0
TLS2_k127_6133023_0 Arylsulfatase K01130 - 3.1.6.1 7.081e-218 689.0
TLS2_k127_6133023_1 Caspase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 503.0
TLS2_k127_6133023_10 Amidohydrolase K03392,K22213 - 4.1.1.45,4.1.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000003663 250.0
TLS2_k127_6133023_11 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000669 250.0
TLS2_k127_6133023_12 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000654 246.0
TLS2_k127_6133023_13 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000009252 243.0
TLS2_k127_6133023_14 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000004473 239.0
TLS2_k127_6133023_15 Esterase of the alpha-beta hydrolase superfamily K07001 GO:0003674,GO:0003824,GO:0016787 - 0.00000000000000000000000000000000000000000000000009585 188.0
TLS2_k127_6133023_16 permease - - - 0.0000000000000000000000000000000000000000001323 175.0
TLS2_k127_6133023_17 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000001788 152.0
TLS2_k127_6133023_18 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000217 146.0
TLS2_k127_6133023_19 peroxiredoxin activity K01607,K04756 - 4.1.1.44 0.0000000000000000000000000000005887 127.0
TLS2_k127_6133023_2 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 380.0
TLS2_k127_6133023_20 metal-dependent phosphoesterases (PHP family) - - - 0.0000000000000000000000000003143 125.0
TLS2_k127_6133023_21 DNA-binding protein with PD1-like DNA-binding motif K06934 - - 0.00000000000000000000000002174 116.0
TLS2_k127_6133023_22 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000001016 114.0
TLS2_k127_6133023_23 DinB family - - - 0.000000000000000000006852 99.0
TLS2_k127_6133023_24 blue (type 1) copper K00368 - 1.7.2.1 0.0000000000000000005111 93.0
TLS2_k127_6133023_25 DinB superfamily - - - 0.0000000000000006274 88.0
TLS2_k127_6133023_26 peptidase inhibitor activity K07260 - 3.4.17.14 0.00000000000001547 83.0
TLS2_k127_6133023_3 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 341.0
TLS2_k127_6133023_4 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 333.0
TLS2_k127_6133023_5 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 311.0
TLS2_k127_6133023_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 317.0
TLS2_k127_6133023_7 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003579 284.0
TLS2_k127_6133023_8 PFAM Ribonuclease BN-like family K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004362 265.0
TLS2_k127_6133023_9 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001996 261.0
TLS2_k127_6133868_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1250.0
TLS2_k127_6133868_1 ABC transporter - - - 0.0 1221.0
TLS2_k127_6133868_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 336.0
TLS2_k127_6133868_11 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 324.0
TLS2_k127_6133868_12 Hsp70 protein K04046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 319.0
TLS2_k127_6133868_13 Transcriptional regulator K07734 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004234 295.0
TLS2_k127_6133868_14 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001762 282.0
TLS2_k127_6133868_15 nitrogen compound transport K02033 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009579 282.0
TLS2_k127_6133868_16 dipeptide transport K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000002869 250.0
TLS2_k127_6133868_17 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000005978 235.0
TLS2_k127_6133868_18 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000002627 219.0
TLS2_k127_6133868_19 SMP-30/Gluconolaconase/LRE-like region - - - 0.000000000000000000000000000000000000000000000000000000000002564 218.0
TLS2_k127_6133868_2 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0 1173.0
TLS2_k127_6133868_20 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000005019 202.0
TLS2_k127_6133868_21 - - - - 0.00000000000000000000000000000000000000000000003175 185.0
TLS2_k127_6133868_22 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.0000000000000000000000000000000000000000000008714 175.0
TLS2_k127_6133868_23 Protein of unknown function (DUF1361) - - - 0.000000000000000000000000000000000000000000004678 171.0
TLS2_k127_6133868_24 succinylglutamate desuccinylase aspartoacylase K06987,K15784 - 3.5.1.125 0.000000000000000000000000000000000003717 150.0
TLS2_k127_6133868_25 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000006867 145.0
TLS2_k127_6133868_26 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000005295 131.0
TLS2_k127_6133868_27 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000001219 136.0
TLS2_k127_6133868_29 hydrolase, family 25 - - - 0.00000000000006438 82.0
TLS2_k127_6133868_3 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 3.548e-281 880.0
TLS2_k127_6133868_30 Catalase K03781 - 1.11.1.6 0.0000009008 53.0
TLS2_k127_6133868_31 - - - - 0.00004229 53.0
TLS2_k127_6133868_4 Propeptide_C25 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 501.0
TLS2_k127_6133868_5 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 454.0
TLS2_k127_6133868_6 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 495.0
TLS2_k127_6133868_7 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 381.0
TLS2_k127_6133868_8 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 366.0
TLS2_k127_6133868_9 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 356.0
TLS2_k127_6139010_0 ABC transporter K06147,K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 561.0
TLS2_k127_6139010_1 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004157 277.0
TLS2_k127_6139010_10 - - - - 0.0000000000000000000015 104.0
TLS2_k127_6139010_11 peptidyl-tyrosine sulfation - - - 0.00000000000000001374 97.0
TLS2_k127_6139010_12 - - - - 0.000001377 60.0
TLS2_k127_6139010_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002094 254.0
TLS2_k127_6139010_3 Protein conserved in bacteria K20444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003687 254.0
TLS2_k127_6139010_5 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000004995 181.0
TLS2_k127_6139010_6 involved in cell wall biogenesis - - - 0.000000000000000000000000000000000000000000001274 173.0
TLS2_k127_6139010_7 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000000000000000000000000000000000000000003896 178.0
TLS2_k127_6139010_8 involved in cell wall biogenesis - - - 0.00000000000000000000000000000000000000000003736 172.0
TLS2_k127_6139010_9 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000000000000000000248 127.0
TLS2_k127_6144703_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.303e-310 959.0
TLS2_k127_6144703_1 PFAM cell divisionFtsK SpoIIIE K03466 - - 3.956e-227 711.0
TLS2_k127_6144703_2 Thi4 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 570.0
TLS2_k127_6144703_3 PFAM CBS domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006199 431.0
TLS2_k127_6144703_4 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000004201 226.0
TLS2_k127_6144703_5 - - - - 0.00000000000000000000000000000002017 128.0
TLS2_k127_6144703_6 PFAM Polyketide cyclase dehydrase - - - 0.00000000000000000000000000001314 123.0
TLS2_k127_6144703_8 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.0000000000000000000000001462 110.0
TLS2_k127_6188963_0 Alpha mannosidase, middle domain K01191 - 3.2.1.24 0.00000000000000002316 97.0
TLS2_k127_619429_0 short-chain dehydrogenase reductase SDR - - - 1.316e-205 658.0
TLS2_k127_619429_1 DegT/DnrJ/EryC1/StrS aminotransferase family K13010,K19430 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 520.0
TLS2_k127_619429_2 Glycosyl hydrolase catalytic core - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005828 364.0
TLS2_k127_619429_3 transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000507 204.0
TLS2_k127_619429_4 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000005243 150.0
TLS2_k127_619429_5 PFAM low molecular weight phosphotyrosine protein phosphatase K01104 - 3.1.3.48 0.000000000000000000000000000000001235 136.0
TLS2_k127_6196538_0 PFAM glycoside hydrolase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 586.0
TLS2_k127_6196538_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 584.0
TLS2_k127_6196538_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000009078 252.0
TLS2_k127_6196538_3 Psort location CytoplasmicMembrane, score K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0000000000000000000000000000000000000000000000003711 199.0
TLS2_k127_6196538_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000295 58.0
TLS2_k127_6202632_0 FAD binding domain K20940 - 1.14.13.218 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008845 512.0
TLS2_k127_6202632_1 PFAM NAD dependent epimerase dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 486.0
TLS2_k127_6202632_10 Integrase core domain K07497 - - 0.000007783 52.0
TLS2_k127_6202632_11 COG2963 Transposase and inactivated derivatives K07483 - - 0.000008697 50.0
TLS2_k127_6202632_2 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000177 242.0
TLS2_k127_6202632_3 nucleotidyltransferase activity K18236 - - 0.00000000000000000000000000000000000000000000000000000000000000000004817 240.0
TLS2_k127_6202632_4 Belongs to the phosphoglycerate mutase family K02226,K15634,K22305 - 3.1.3.3,3.1.3.73,5.4.2.12 0.0000000000000000000000000000000000000000000000000000002917 201.0
TLS2_k127_6202632_5 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000007586 199.0
TLS2_k127_6202632_6 Domain of unknown function (DUF4365) - - - 0.0000000000000000002769 93.0
TLS2_k127_6202632_8 Domain of unknown function (DUF4365) - - - 0.00000000001263 73.0
TLS2_k127_6202632_9 positive regulation of macromolecule biosynthetic process K03970,K03973 - - 0.00000000004444 65.0
TLS2_k127_6214305_0 Bacterial membrane protein YfhO - - - 1.507e-238 766.0
TLS2_k127_6214305_1 Alkaline and neutral invertase - - - 1.228e-221 697.0
TLS2_k127_6214305_10 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000000000000000003555 212.0
TLS2_k127_6214305_11 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000005406 202.0
TLS2_k127_6214305_12 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000008066 156.0
TLS2_k127_6214305_2 PFAM extracellular solute-binding protein family 1 K02027,K10188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 516.0
TLS2_k127_6214305_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 428.0
TLS2_k127_6214305_4 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 398.0
TLS2_k127_6214305_5 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 356.0
TLS2_k127_6214305_6 Protein of unknown function (DUF4256) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 321.0
TLS2_k127_6214305_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 306.0
TLS2_k127_6214305_9 PFAM RDD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000008514 220.0
TLS2_k127_6229906_0 PFAM ABC transporter related K16786,K16787 - - 2.422e-229 724.0
TLS2_k127_6229906_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 513.0
TLS2_k127_6229906_2 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K16785 - - 0.00000000000000000000000000000000000000000000000000000000000000001315 234.0
TLS2_k127_6229906_3 COG0202 DNA-directed RNA polymerase, alpha subunit 40 kD subunit - - - 0.0000000000000000000000000000000000000000000000000009914 186.0
TLS2_k127_6229906_4 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000818 149.0
TLS2_k127_6229906_5 Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source K01483 - 4.3.2.3 0.000001239 52.0
TLS2_k127_6277813_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 438.0
TLS2_k127_6277813_1 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032,K10823,K10824 - 3.6.3.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 386.0
TLS2_k127_6277813_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 383.0
TLS2_k127_6277813_3 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 361.0
TLS2_k127_6277813_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 315.0
TLS2_k127_6277813_5 PFAM magnesium chelatase ChlI subunit K07391 - - 0.0000000000000000000000004908 107.0
TLS2_k127_6306672_0 L-seryl-tRNASec selenium transferase activity K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 409.0
TLS2_k127_6306672_1 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000231 224.0
TLS2_k127_6306672_2 mandelate racemase muconate lactonizing K01684 - 4.2.1.6 0.000000000000000000000000000000000000000000000000000000003713 201.0
TLS2_k127_6306672_3 Protein of unknown function (DUF433) - - - 0.0000000000000000000001426 98.0
TLS2_k127_6306672_4 SMART Tetratricopeptide domain protein - - - 0.000007524 58.0
TLS2_k127_630674_0 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002487 257.0
TLS2_k127_630674_1 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000000000000000002644 178.0
TLS2_k127_630674_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000006775 169.0
TLS2_k127_63068_0 Xanthine dehydrogenase, molybdenum binding subunit - - - 4.55e-322 1015.0
TLS2_k127_63068_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 586.0
TLS2_k127_63068_10 Multicopper oxidase K04753 - - 0.000000000000000000000001287 104.0
TLS2_k127_63068_11 xanthine dehydrogenase activity K03519,K12529 - 1.2.5.3 0.000000000000000000000004887 111.0
TLS2_k127_63068_12 regulator - - - 0.0000000000004651 76.0
TLS2_k127_63068_13 PFAM SMP-30 Gluconolaconase - - - 0.00007813 49.0
TLS2_k127_63068_2 Binding-protein-dependent transport system inner membrane component K02033,K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 447.0
TLS2_k127_63068_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 423.0
TLS2_k127_63068_4 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000001501 225.0
TLS2_k127_63068_5 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000003608 203.0
TLS2_k127_63068_6 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000001219 186.0
TLS2_k127_63068_7 PHP domain protein - - - 0.00000000000000000000000000000000000000000000001636 188.0
TLS2_k127_63068_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000883 160.0
TLS2_k127_63068_9 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000003815 150.0
TLS2_k127_6314658_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 2.014e-266 846.0
TLS2_k127_6314658_1 COG0659 Sulfate permease and related transporters (MFS superfamily) K03321 - - 1.414e-228 716.0
TLS2_k127_6314658_2 PFAM aminotransferase class V K04127 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 462.0
TLS2_k127_6314658_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 460.0
TLS2_k127_6314658_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 392.0
TLS2_k127_6314658_5 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 319.0
TLS2_k127_6314658_6 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 319.0
TLS2_k127_6314658_7 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003376 280.0
TLS2_k127_6314658_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000002572 179.0
TLS2_k127_6314658_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000268 90.0
TLS2_k127_6318440_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.0 1388.0
TLS2_k127_6318440_1 Bacterial transcriptional activator domain - - - 7.672e-263 851.0
TLS2_k127_631991_0 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 524.0
TLS2_k127_631991_1 methyltransferase K00563,K07112 - 2.1.1.187 0.000000000000000000000000000000000000000000000000000000000003642 218.0
TLS2_k127_631991_2 acetyltransferase - - - 0.00000000000000000000000000001166 124.0
TLS2_k127_631991_3 mandelate racemase muconate lactonizing K01706 - 4.2.1.40 0.0000000009741 70.0
TLS2_k127_6328945_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008119 589.0
TLS2_k127_6328945_1 Aminotransferase K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005615 515.0
TLS2_k127_6328945_2 ribonuclease inhibitor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 347.0
TLS2_k127_6328945_3 Cytotoxic translational repressor of toxin-antitoxin stability system - - - 0.000000000608 61.0
TLS2_k127_6349515_1 Phenazine biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004391 356.0
TLS2_k127_6349515_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008563 251.0
TLS2_k127_6349515_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000036 233.0
TLS2_k127_6349515_4 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000003798 201.0
TLS2_k127_6349515_5 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000004658 162.0
TLS2_k127_6349515_6 Proton-conducting membrane transporter - - - 0.000000000000000000000000000000000001293 147.0
TLS2_k127_6349515_7 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000001467 138.0
TLS2_k127_6349515_8 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000001299 92.0
TLS2_k127_6349515_9 Serine kinase of the HPr protein, regulates carbohydrate metabolism - - - 0.00000000002817 70.0
TLS2_k127_6361216_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009239 501.0
TLS2_k127_6361216_1 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003228 282.0
TLS2_k127_6361216_3 transcriptional regulator, LuxR family - - - 0.0000000000000002225 80.0
TLS2_k127_6361216_4 PFAM NMT1 THI5 like domain protein K02051 - - 0.0000000000000005767 78.0
TLS2_k127_6376358_0 Cellobiose phosphorylase K00702,K13688,K18675 - 2.4.1.20,2.4.1.280 0.0 1570.0
TLS2_k127_6376358_1 PFAM magnesium chelatase ChlI subunit K07391 - - 0.000000000000000000000000000000000000007634 149.0
TLS2_k127_6376358_2 Histidine kinase - - - 0.000000000000003413 82.0
TLS2_k127_6376358_3 Protein of unknown function (DUF2442) - - - 0.0003987 44.0
TLS2_k127_6376580_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 520.0
TLS2_k127_6376580_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 394.0
TLS2_k127_6376580_2 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001168 259.0
TLS2_k127_6376580_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004722 230.0
TLS2_k127_6376580_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000002 210.0
TLS2_k127_6376580_5 Sugar-specific transcriptional regulator TrmB - - - 0.00000000000000000000000000000000000000000000033 172.0
TLS2_k127_6376580_6 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.000000000000000000000000000000000000000001138 162.0
TLS2_k127_6376580_7 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000005882 132.0
TLS2_k127_6396330_0 dihydrodipicolinate synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 436.0
TLS2_k127_6396330_1 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 399.0
TLS2_k127_6396330_2 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000001026 181.0
TLS2_k127_6396330_3 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.000000000000000000000000000000000002276 149.0
TLS2_k127_6396330_4 glycerophosphodiester transmembrane transport K02026,K05815 - - 0.00000000000005925 72.0
TLS2_k127_6396330_5 inositol 2-dehydrogenase activity - - - 0.000000000005084 68.0
TLS2_k127_6396330_6 polysaccharide deacetylase - - - 0.000006478 57.0
TLS2_k127_6423216_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 1.52e-303 946.0
TLS2_k127_6423216_1 PFAM ABC transporter transmembrane region K06147 - - 8.035e-285 887.0
TLS2_k127_6423216_10 Lon protease (S16) C-terminal proteolytic domain K07177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006169 271.0
TLS2_k127_6423216_11 Ferredoxin K04755 - - 0.000000000000000000000000000000000000000000000000000000000077 205.0
TLS2_k127_6423216_12 COG2346, Truncated hemoglobins K06886 - - 0.00000000000000000000000000000000000000000000000000004498 192.0
TLS2_k127_6423216_13 Major Facilitator Superfamily K08223 - - 0.00000000000000000000000000000000000000000000003099 184.0
TLS2_k127_6423216_14 amidohydrolase - - - 0.00000000000000000000000000000000001289 147.0
TLS2_k127_6423216_15 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000002098 131.0
TLS2_k127_6423216_16 LysM domain K03642,K03791,K22278 - 3.5.1.104 0.00000000000000000000009076 106.0
TLS2_k127_6423216_17 Extracellular solute-binding protein - - - 0.00005449 52.0
TLS2_k127_6423216_2 PFAM ABC transporter transmembrane region K06147 - - 6.197e-273 855.0
TLS2_k127_6423216_3 PFAM ABC transporter transmembrane region K06147 - - 1.438e-225 714.0
TLS2_k127_6423216_4 ABC transporter K06147 - - 5.541e-215 687.0
TLS2_k127_6423216_5 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 546.0
TLS2_k127_6423216_6 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 503.0
TLS2_k127_6423216_7 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 504.0
TLS2_k127_6423216_8 Sulfatase K01133 - 3.1.6.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 492.0
TLS2_k127_6423216_9 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006993 471.0
TLS2_k127_6433907_0 - - - - 0.00000000000000000000000000000003122 141.0
TLS2_k127_6433907_1 Pkd domain containing protein - - - 0.00000000000000000000000001046 124.0
TLS2_k127_6452072_0 trisaccharide binding K03556 - - 9.402e-205 671.0
TLS2_k127_6452072_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 343.0
TLS2_k127_6452072_2 ABC-type spermidine putrescine transport system, permease component II K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 319.0
TLS2_k127_6452072_3 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000001587 78.0
TLS2_k127_6452741_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1078.0
TLS2_k127_6452741_1 Domain of unknown function (DUF4347) - - - 0.0000000000000000000000000000000000002867 164.0
TLS2_k127_6452741_2 PKD domain - - - 0.0000000000000000000000004619 124.0
TLS2_k127_6452741_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000001724 103.0
TLS2_k127_6452741_5 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000001231 59.0
TLS2_k127_6452741_6 NHL repeat - - - 0.00001832 59.0
TLS2_k127_6473678_0 Thiamine pyrophosphate protein TPP binding domain protein K01652 - 2.2.1.6 0.0 1017.0
TLS2_k127_6473678_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 557.0
TLS2_k127_6473678_2 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 464.0
TLS2_k127_6473678_3 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 462.0
TLS2_k127_6473678_4 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008531 287.0
TLS2_k127_6473678_5 Beta-lactamase K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000002572 252.0
TLS2_k127_6473678_6 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000008332 220.0
TLS2_k127_6473678_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000001175 153.0
TLS2_k127_6473678_8 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.0000000000000000000000000000004103 126.0
TLS2_k127_6473678_9 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649,K02594 - 2.3.3.13,2.3.3.14 0.00000000000000000000000008798 109.0
TLS2_k127_648340_0 dipeptide transport K02035 - - 1.775e-223 704.0
TLS2_k127_648340_1 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 4.707e-206 664.0
TLS2_k127_648340_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 417.0
TLS2_k127_648340_3 Domain in cystathionine beta-synthase and other proteins. K02000 - 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 419.0
TLS2_k127_648340_4 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 338.0
TLS2_k127_648340_5 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 323.0
TLS2_k127_648340_6 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 338.0
TLS2_k127_648340_7 Glycine betaine L-proline transport system permease protein K02001,K02002 GO:0003674,GO:0005215,GO:0005275,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0015871,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0031460,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 293.0
TLS2_k127_648340_8 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000007877 139.0
TLS2_k127_6487961_0 HELICc2 K03722 - 3.6.4.12 4.186e-318 994.0
TLS2_k127_6487961_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 4.076e-215 677.0
TLS2_k127_6487961_10 Protein of unknown function (DUF423) - - - 0.000000000000000000000000000000000000000000000000000003655 192.0
TLS2_k127_6487961_11 Histidine phosphatase superfamily (branch 1) K01834 - 5.4.2.11 0.00000000000000000000000000000000000000000000000000006217 199.0
TLS2_k127_6487961_12 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000483 165.0
TLS2_k127_6487961_13 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000001416 138.0
TLS2_k127_6487961_14 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000002243 132.0
TLS2_k127_6487961_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 582.0
TLS2_k127_6487961_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 578.0
TLS2_k127_6487961_4 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 511.0
TLS2_k127_6487961_5 Baseplate J-like protein K01218 - 3.2.1.78 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 482.0
TLS2_k127_6487961_6 Pyrimidine nucleoside phosphorylase C-terminal domain K00756,K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 477.0
TLS2_k127_6487961_7 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 376.0
TLS2_k127_6487961_8 sh3 domain protein K01447 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003741 280.0
TLS2_k127_6487961_9 Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP K01004 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576 2.7.8.24 0.0000000000000000000000000000000000000000000000000000009966 201.0
TLS2_k127_6543487_0 positive regulation of growth K19687 - - 0.0 1529.0
TLS2_k127_6543487_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 594.0
TLS2_k127_6543487_10 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003244 260.0
TLS2_k127_6543487_11 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000002003 244.0
TLS2_k127_6543487_12 PFAM Formylglycine-generating sulfatase enzyme K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000007341 232.0
TLS2_k127_6543487_13 PFAM AAA-4 family protein K02444,K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000001205 175.0
TLS2_k127_6543487_2 heme binding K21471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 556.0
TLS2_k127_6543487_3 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 495.0
TLS2_k127_6543487_4 3'(2'),5'-bisphosphate nucleotidase activity K01082 - 3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 447.0
TLS2_k127_6543487_5 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 414.0
TLS2_k127_6543487_6 Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 382.0
TLS2_k127_6543487_8 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 302.0
TLS2_k127_6543487_9 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000009591 261.0
TLS2_k127_6560842_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 572.0
TLS2_k127_6560842_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 539.0
TLS2_k127_6560842_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004012 277.0
TLS2_k127_6560842_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000055 218.0
TLS2_k127_6572858_0 ATP-binding region, ATPase domain protein K03407 - 2.7.13.3 3.654e-216 698.0
TLS2_k127_6572858_1 membrane protein involved in D-alanine export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 525.0
TLS2_k127_6572858_10 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 311.0
TLS2_k127_6572858_11 ABC-type sugar transport systems, permease components K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 313.0
TLS2_k127_6572858_12 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 325.0
TLS2_k127_6572858_13 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 299.0
TLS2_k127_6572858_14 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 303.0
TLS2_k127_6572858_15 PFAM binding-protein-dependent transport systems inner membrane component K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 293.0
TLS2_k127_6572858_16 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000712 291.0
TLS2_k127_6572858_17 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001967 285.0
TLS2_k127_6572858_18 N-terminal TM domain of oligopeptide transport permease C K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001251 275.0
TLS2_k127_6572858_19 ABC transporter substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006102 280.0
TLS2_k127_6572858_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412,K13491 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008254 398.0
TLS2_k127_6572858_20 Secretory lipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005537 277.0
TLS2_k127_6572858_21 transmembrane transport K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009166 280.0
TLS2_k127_6572858_22 COGs COG0395 ABC-type sugar transport system permease component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001161 264.0
TLS2_k127_6572858_23 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000004004 199.0
TLS2_k127_6572858_24 ABC transporter permease K02026 - - 0.000000000000000000000000000000000000000000000007241 183.0
TLS2_k127_6572858_25 PhoQ Sensor K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000001837 151.0
TLS2_k127_6572858_27 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000001184 119.0
TLS2_k127_6572858_28 COGs COG0601 ABC-type dipeptide oligopeptide nickel transport systems permease components K02033 - - 0.00000000000000000004518 98.0
TLS2_k127_6572858_29 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000005114 91.0
TLS2_k127_6572858_3 Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 391.0
TLS2_k127_6572858_30 ABC-type sugar transport system, periplasmic component K02027,K17244 - - 0.0000000000000000003969 101.0
TLS2_k127_6572858_31 - - - - 0.00000000000007921 83.0
TLS2_k127_6572858_32 Bacterial extracellular solute-binding protein - - - 0.0000000005357 72.0
TLS2_k127_6572858_33 transposase activity - - - 0.00001174 56.0
TLS2_k127_6572858_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 400.0
TLS2_k127_6572858_5 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 357.0
TLS2_k127_6572858_6 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009871 352.0
TLS2_k127_6572858_7 dioxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 345.0
TLS2_k127_6572858_8 COGs COG0395 ABC-type sugar transport system permease component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 332.0
TLS2_k127_6572858_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 348.0
TLS2_k127_6577811_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1136.0
TLS2_k127_6577811_1 Phosphoglucomutase/phosphomannomutase, C-terminal domain - - - 7.936e-209 664.0
TLS2_k127_6577811_10 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000002385 128.0
TLS2_k127_6577811_11 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000002516 124.0
TLS2_k127_6577811_13 -O-antigen K13009,K18814 - - 0.00000000000000000000002562 115.0
TLS2_k127_6577811_14 Methyltransferase domain - - - 0.00000000000000000000003104 102.0
TLS2_k127_6577811_15 Methyltransferase domain - - - 0.0000000000000004051 81.0
TLS2_k127_6577811_16 transposase or invertase - - - 0.000000000000009713 76.0
TLS2_k127_6577811_17 transposase or invertase - - - 0.00001226 51.0
TLS2_k127_6577811_2 PFAM deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 580.0
TLS2_k127_6577811_3 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K01710,K02377 - 1.1.1.271,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 538.0
TLS2_k127_6577811_4 PFAM sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 424.0
TLS2_k127_6577811_5 Arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 404.0
TLS2_k127_6577811_6 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 370.0
TLS2_k127_6577811_7 arginine decarboxylase activity K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 311.0
TLS2_k127_6577811_8 Chain length determinant protein - - - 0.0000000000000000000000000000000000000000000000000000000000000003782 246.0
TLS2_k127_6577811_9 - - - - 0.00000000000000000000000000000000000000000000004415 177.0
TLS2_k127_662262_0 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 589.0
TLS2_k127_662262_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 489.0
TLS2_k127_662262_2 Homoserine dehydrogenase K00003,K12524 - 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 486.0
TLS2_k127_662262_3 D-mannonate dehydratase (UxuA) K01686 - 4.2.1.8 0.0000001244 57.0
TLS2_k127_6662647_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 4.657e-230 722.0
TLS2_k127_6662647_1 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 7.91e-215 677.0
TLS2_k127_6662647_2 LysM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 593.0
TLS2_k127_6662647_3 Catalyzes the release of L-lysine from LysW -gamma-L- lysine K05831 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 469.0
TLS2_k127_6662647_4 antibiotic catabolic process K13277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009137 268.0
TLS2_k127_666553_0 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 2.17e-253 788.0
TLS2_k127_666553_1 SMART Elongator protein 3 MiaB NifB - - - 2.534e-247 772.0
TLS2_k127_666553_10 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000001039 200.0
TLS2_k127_666553_11 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000123 111.0
TLS2_k127_666553_12 - - - - 0.000000000000000000002716 109.0
TLS2_k127_666553_13 -O-antigen K01179,K05991,K13009 - 3.2.1.123,3.2.1.4 0.00000002577 67.0
TLS2_k127_666553_14 COG3307 Lipid A core - O-antigen ligase and related enzymes K18814 - - 0.0007534 52.0
TLS2_k127_666553_2 SMART Elongator protein 3 MiaB NifB - - - 1.909e-213 681.0
TLS2_k127_666553_3 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 528.0
TLS2_k127_666553_4 radical SAM domain protein K06137,K06138 - 1.3.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 361.0
TLS2_k127_666553_5 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 341.0
TLS2_k127_666553_6 polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 328.0
TLS2_k127_666553_7 nucleotidyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 309.0
TLS2_k127_666553_8 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001172 280.0
TLS2_k127_666553_9 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000001128 231.0
TLS2_k127_6669770_0 Tricorn protease homolog K08676 - - 0.0 1433.0
TLS2_k127_6669770_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 411.0
TLS2_k127_6669770_2 PFAM Biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 355.0
TLS2_k127_6669770_3 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001474 276.0
TLS2_k127_6669770_4 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000000000000000006263 214.0
TLS2_k127_6669770_5 Protein conserved in bacteria K09764 - - 0.000000000000000000000000000000000000001368 149.0
TLS2_k127_6669770_6 Antibiotic synthesis protein MbtH K05375 - - 0.00000000001573 67.0
TLS2_k127_6690608_0 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 395.0
TLS2_k127_6690608_1 KR domain K00038 - 1.1.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008316 389.0
TLS2_k127_6690608_2 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 387.0
TLS2_k127_6690608_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000004612 219.0
TLS2_k127_6690608_4 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000006014 200.0
TLS2_k127_6690608_5 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000000000000000008361 142.0
TLS2_k127_6690608_6 Glycoside Hydrolase Family K06306 - - 0.0000001066 53.0
TLS2_k127_6716887_0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - 4.246e-196 619.0
TLS2_k127_6716887_1 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 532.0
TLS2_k127_6719331_0 Selenocysteine-specific translation elongation factor K03833 - - 1.7e-227 721.0
TLS2_k127_6719331_1 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 567.0
TLS2_k127_6719331_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 523.0
TLS2_k127_6719331_3 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005773 455.0
TLS2_k127_6719331_4 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 389.0
TLS2_k127_6719331_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 381.0
TLS2_k127_6735822_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 3.178e-291 919.0
TLS2_k127_6735822_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 1.021e-278 865.0
TLS2_k127_6735822_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 322.0
TLS2_k127_6735822_11 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008264 306.0
TLS2_k127_6735822_12 sh3 domain protein K01448,K04771 - 3.4.21.107,3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001333 279.0
TLS2_k127_6735822_13 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000002086 244.0
TLS2_k127_6735822_14 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000001272 234.0
TLS2_k127_6735822_15 PFAM AzlC family protein - - - 0.0000000000000000000000000000000000000000000000000000000001404 213.0
TLS2_k127_6735822_16 KR domain - - - 0.000000000000000000000000000000000000000000000000000001473 200.0
TLS2_k127_6735822_17 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000001136 197.0
TLS2_k127_6735822_18 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K18983,K20023 - 4.2.1.156,4.2.1.42,5.5.1.27 0.000000000000000000000000000001313 123.0
TLS2_k127_6735822_19 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000008175 116.0
TLS2_k127_6735822_2 Protein of unknown function (DUF2961) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 496.0
TLS2_k127_6735822_20 Amidase K01426 - 3.5.1.4 0.000000000000000001644 86.0
TLS2_k127_6735822_21 - - - - 0.00000000000000002174 88.0
TLS2_k127_6735822_22 Branched-chain amino acid transport protein (AzlD) - - - 0.0000001475 63.0
TLS2_k127_6735822_23 - - - - 0.0000004024 52.0
TLS2_k127_6735822_24 Rhodanese Homology Domain - - - 0.000001475 55.0
TLS2_k127_6735822_25 COG2834 Outer membrane lipoprotein-sorting protein - - - 0.000003454 57.0
TLS2_k127_6735822_26 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.0001823 50.0
TLS2_k127_6735822_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 479.0
TLS2_k127_6735822_4 COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 466.0
TLS2_k127_6735822_5 Protein of unknown function (DUF4038) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009994 413.0
TLS2_k127_6735822_6 Luciferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 403.0
TLS2_k127_6735822_7 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K18983,K20023 - 4.2.1.156,4.2.1.42,5.5.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 362.0
TLS2_k127_6735822_8 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 364.0
TLS2_k127_6735822_9 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 367.0
TLS2_k127_6735944_0 TIGRFAM F420-dependent oxidoreductase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 383.0
TLS2_k127_6735944_1 succinylglutamate desuccinylase aspartoacylase K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 342.0
TLS2_k127_6735944_2 lactoylglutathione lyase activity K01239 - 3.2.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004307 254.0
TLS2_k127_6735944_3 Putative ATPase subunit of terminase (gpP-like) - - - 0.0000000000000000000000000000000000000002787 154.0
TLS2_k127_6735944_4 Putative ATPase subunit of terminase (gpP-like) - - - 0.00000000000001141 75.0
TLS2_k127_6735944_5 PFAM Archaeal ATPase - - - 0.000000000001285 79.0
TLS2_k127_6755889_0 Transcriptional activator domain - - - 1.124e-204 676.0
TLS2_k127_6755889_1 TIGRFAM pseudaminic acid synthase K01654,K15898 - 2.5.1.56,2.5.1.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 523.0
TLS2_k127_6755889_10 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000001948 142.0
TLS2_k127_6755889_11 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000525 132.0
TLS2_k127_6755889_12 Male sterility protein - - - 0.0000000000000000000000007138 115.0
TLS2_k127_6755889_13 Putative cyclase - - - 0.0000000000000009097 85.0
TLS2_k127_6755889_14 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000002434 72.0
TLS2_k127_6755889_15 Family of unknown function (DUF5317) - - - 0.00000000163 66.0
TLS2_k127_6755889_17 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000009326 63.0
TLS2_k127_6755889_2 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 496.0
TLS2_k127_6755889_3 Sh3 type 3 domain protein K01448,K07448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 429.0
TLS2_k127_6755889_4 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 329.0
TLS2_k127_6755889_5 COGs COG0395 ABC-type sugar transport system permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001523 284.0
TLS2_k127_6755889_6 PFAM binding-protein-dependent transport systems inner membrane component K02025,K17242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002192 268.0
TLS2_k127_6755889_7 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000002499 230.0
TLS2_k127_6755889_8 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000004438 222.0
TLS2_k127_6755889_9 amine dehydrogenase activity - - - 0.0000000000000000000000000000000004682 139.0
TLS2_k127_67572_0 CotH kinase protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 634.0
TLS2_k127_67572_1 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 478.0
TLS2_k127_67572_10 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000005818 218.0
TLS2_k127_67572_11 Domain of unknown function (DUF4956) - - - 0.00000000000000000000000000000000000000000000000000000000001202 213.0
TLS2_k127_67572_12 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000003255 213.0
TLS2_k127_67572_13 VTC domain - - - 0.000000000000000000000000000000000000000000000000000007887 199.0
TLS2_k127_67572_14 Streptomycin adenylyltransferase K05593 - - 0.0000000000000000000000000000000000000000000000001619 188.0
TLS2_k127_67572_15 - - - - 0.0000000000000000000000000000001963 129.0
TLS2_k127_67572_2 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 391.0
TLS2_k127_67572_3 ABC transporter, ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 389.0
TLS2_k127_67572_4 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 383.0
TLS2_k127_67572_5 carboxylic acid catabolic process K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 373.0
TLS2_k127_67572_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 381.0
TLS2_k127_67572_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 294.0
TLS2_k127_67572_8 2-keto-3-deoxy-L-rhamnonate aldolase activity K02510,K12660 - 4.1.2.52,4.1.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000009341 265.0
TLS2_k127_67572_9 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000001826 228.0
TLS2_k127_6773712_0 oligosaccharyl transferase activity K07151 - 2.4.99.18 1.124e-236 747.0
TLS2_k127_6773712_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 594.0
TLS2_k127_6773712_2 PFAM NAD-dependent epimerase dehydratase K15856 - 1.1.1.281 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 488.0
TLS2_k127_6773712_3 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 437.0
TLS2_k127_6773712_4 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000008843 233.0
TLS2_k127_6773712_5 GDP-mannose mannosyl hydrolase activity K03574,K13669 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000003864 213.0
TLS2_k127_6773712_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000005064 141.0
TLS2_k127_6773712_8 - - - - 0.00000000000000000000000000000007082 130.0
TLS2_k127_6773962_0 heavy metal translocating P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 1.729e-285 893.0
TLS2_k127_6773962_1 Domain of unknown function (DUF4142) - - - 0.000000000000000000000000000000000000000000000004964 177.0
TLS2_k127_6773962_2 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000001197 87.0
TLS2_k127_6773962_3 - - - - 0.0000000009745 69.0
TLS2_k127_6773962_4 - - - - 0.000000001446 69.0
TLS2_k127_677929_0 PFAM type II secretion system protein E K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 598.0
TLS2_k127_677929_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 469.0
TLS2_k127_677929_2 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009931 353.0
TLS2_k127_677929_3 PFAM type II secretion system protein K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005214 283.0
TLS2_k127_677929_4 PFAM type II secretion system protein K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009262 273.0
TLS2_k127_677929_5 Flp pilus assembly protein CpaB K02279 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009107 265.0
TLS2_k127_677929_6 KaiC - - - 0.0000000000000000000000000000000000000000000000000000000006605 214.0
TLS2_k127_677929_7 TadE-like protein - - - 0.000000003703 63.0
TLS2_k127_6792810_0 PFAM NADH-Ubiquinone oxidoreductase (complex I), chain 5 L domain protein K00341 - 1.6.5.3 4.388e-229 717.0
TLS2_k127_6792810_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 540.0
TLS2_k127_6792810_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000041 264.0
TLS2_k127_6792810_3 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000008089 191.0
TLS2_k127_6792810_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000003127 183.0
TLS2_k127_6792810_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.000000000000000000000000000000000000000000000001467 176.0
TLS2_k127_6792810_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.00000000000000000000000000000000000000005731 153.0
TLS2_k127_6793008_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 3.702e-295 914.0
TLS2_k127_6793008_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 3.292e-246 776.0
TLS2_k127_6793008_2 PFAM Citrate transporter - - - 4.465e-198 636.0
TLS2_k127_6793008_3 Aminotransferase K11358 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 450.0
TLS2_k127_6793008_4 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 303.0
TLS2_k127_6793008_5 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003456 278.0
TLS2_k127_6793008_6 CRISPR-associated helicase Cas3 K07012 - - 0.0000000000000000000000000004175 119.0
TLS2_k127_6793008_7 sigma-70 region 2 domain protein K03088 - - 0.00000000000000000000107 97.0
TLS2_k127_6793008_8 PFAM nucleic acid binding, OB-fold, tRNA K01174 - 3.1.31.1 0.0000000000001549 80.0
TLS2_k127_6795638_0 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 504.0
TLS2_k127_6795638_1 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 320.0
TLS2_k127_6795638_2 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000004069 196.0
TLS2_k127_6795638_3 - K06909 - - 0.000000000000006051 78.0
TLS2_k127_6795638_4 Wd40 repeat-containing protein - - - 0.0000007384 64.0
TLS2_k127_6795638_5 Glyoxalase-like domain K08234 - - 0.00001211 54.0
TLS2_k127_6802068_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 5.683e-231 743.0
TLS2_k127_6802068_1 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000001195 149.0
TLS2_k127_6805263_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.603e-294 919.0
TLS2_k127_6805263_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 2.868e-229 724.0
TLS2_k127_6805263_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 0.0000000000000000000000000000000000000000000000000000004109 200.0
TLS2_k127_6805263_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000333 166.0
TLS2_k127_6805263_4 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000001336 158.0
TLS2_k127_6805263_5 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.000000000000000000000008355 102.0
TLS2_k127_6805263_6 PFAM magnesium chelatase ChlI subunit K07391 - - 0.000000000000001176 78.0
TLS2_k127_6816236_0 mandelate racemase muconate lactonizing K01684 - 4.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 582.0
TLS2_k127_6816236_1 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 377.0
TLS2_k127_6816236_2 PFAM cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 350.0
TLS2_k127_6816236_3 glycosyl transferase family 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002649 240.0
TLS2_k127_6816236_4 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000006225 213.0
TLS2_k127_6816236_5 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000001525 209.0
TLS2_k127_6816236_6 - - - - 0.00000000000000000000000000000001796 140.0
TLS2_k127_6816236_7 Transcriptional regulator K13653 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:1901575,GO:1901576,GO:1901615,GO:1901617 - 0.0009261 51.0
TLS2_k127_6820842_0 histidine kinase A domain protein - - - 1.042e-215 683.0
TLS2_k127_6820842_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 569.0
TLS2_k127_6820842_2 CBS domain containing protein K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 384.0
TLS2_k127_6820842_3 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 374.0
TLS2_k127_6820842_4 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000000000000000007517 146.0
TLS2_k127_6830534_0 PFAM Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 301.0
TLS2_k127_6830534_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 295.0
TLS2_k127_6830534_2 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003842 285.0
TLS2_k127_6830534_3 PFAM Xylose isomerase domain-containing protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003683 261.0
TLS2_k127_6830534_4 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000143 130.0
TLS2_k127_6830534_5 Pfam Sulfatase K01133 - 3.1.6.6 0.00000000000000000003166 92.0
TLS2_k127_6830534_6 Resolvase, N terminal domain - - - 0.0000004257 52.0
TLS2_k127_6830534_7 Male sterility protein K01784 - 5.1.3.2 0.0002768 53.0
TLS2_k127_6837826_0 Protein-glutamate methylesterase K13924 - 2.1.1.80,3.1.1.61 2.578e-214 715.0
TLS2_k127_6837826_1 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 545.0
TLS2_k127_6837826_10 Low-potential electron donor to a number of redox enzymes K03839 - - 0.0000000000000000000000000000000000000000000000146 177.0
TLS2_k127_6837826_11 Methyltransferase domain - - - 0.00000000000000000000002831 101.0
TLS2_k127_6837826_12 ABC-type Fe3 transport system permease component K02011 - - 0.0000000000001089 76.0
TLS2_k127_6837826_13 - - - - 0.0000000000005721 78.0
TLS2_k127_6837826_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 424.0
TLS2_k127_6837826_3 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 411.0
TLS2_k127_6837826_4 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 407.0
TLS2_k127_6837826_5 peroxidase activity K00435 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 305.0
TLS2_k127_6837826_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000268 258.0
TLS2_k127_6837826_7 TIGRFAM phosphoserine phosphatase homoserine phosphotransferase bifunctional protein K02203 - 2.7.1.39,3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000003311 231.0
TLS2_k127_6837826_8 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000005056 222.0
TLS2_k127_6837826_9 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000005631 229.0
TLS2_k127_6850652_0 Sulfate permease family K03321 - - 9.303e-223 704.0
TLS2_k127_6850652_1 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006697 366.0
TLS2_k127_6850652_2 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 320.0
TLS2_k127_6850652_3 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001906 274.0
TLS2_k127_6850652_4 Domain of unknown function (DUF1949) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002199 263.0
TLS2_k127_6850652_5 Modulates RecA activity K03565 - - 0.00000000000000000000000000000000000000000000000000007457 194.0
TLS2_k127_6850652_6 Bacteriocin-protection, YdeI or OmpD-Associated K06878 - - 0.0000000000000000000000000000000000000000000008134 171.0
TLS2_k127_6850652_7 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000001236 179.0
TLS2_k127_685548_0 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 0.0 1116.0
TLS2_k127_685548_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.962e-245 767.0
TLS2_k127_685548_10 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000009913 241.0
TLS2_k127_685548_11 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000000000000000000000000000004194 232.0
TLS2_k127_685548_12 - - - - 0.000000000000000000000000000000000000000000000000000003988 201.0
TLS2_k127_685548_13 belongs to the PRA-CH family K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000003264 158.0
TLS2_k127_685548_14 Protein of unknown function (DUF402) K07586 - - 0.0000000000000000000000000000000000000003012 156.0
TLS2_k127_685548_15 Phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.00000000000000000000000003727 110.0
TLS2_k127_685548_16 Bacterial transcriptional activator domain - - - 0.0000000000000000000006487 98.0
TLS2_k127_685548_17 phosphoglycerate mutase - - - 0.00000000007299 71.0
TLS2_k127_685548_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 4.628e-229 714.0
TLS2_k127_685548_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006616 589.0
TLS2_k127_685548_4 PFAM FAD dependent oxidoreductase K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 484.0
TLS2_k127_685548_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 469.0
TLS2_k127_685548_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 419.0
TLS2_k127_685548_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009092 373.0
TLS2_k127_685548_8 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 365.0
TLS2_k127_685548_9 oxidoreductase activity, acting on CH-OH group of donors K18009 - 1.1.1.304,1.1.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008882 320.0
TLS2_k127_6855520_0 PFAM penicillin-binding protein transpeptidase K05515 - 3.4.16.4 9.9e-300 934.0
TLS2_k127_6855520_1 Glycosyltransferase WbsX - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005982 516.0
TLS2_k127_6855520_10 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000001908 227.0
TLS2_k127_6855520_11 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization K03610 - - 0.000000000000000000000000000000000000000000000000000000001091 218.0
TLS2_k127_6855520_12 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.000000000000000000000000000000000000000000000004758 177.0
TLS2_k127_6855520_13 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000001804 169.0
TLS2_k127_6855520_14 Belongs to the SEDS family K05837 - - 0.0000000000000000000001198 99.0
TLS2_k127_6855520_16 PFAM ABC-2 type transporter K01992 - - 0.0000000004177 72.0
TLS2_k127_6855520_2 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 458.0
TLS2_k127_6855520_3 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 445.0
TLS2_k127_6855520_4 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 389.0
TLS2_k127_6855520_5 Belongs to the ParA family K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 365.0
TLS2_k127_6855520_6 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075,K15780 - 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 361.0
TLS2_k127_6855520_7 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 321.0
TLS2_k127_6855520_8 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 289.0
TLS2_k127_6855520_9 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002781 284.0
TLS2_k127_6865354_0 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 488.0
TLS2_k127_6865354_1 MlrC C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 459.0
TLS2_k127_6865354_10 Lamin Tail Domain - - - 0.0000000000000000000000000000000000361 143.0
TLS2_k127_6865354_11 Xylose isomerase-like TIM barrel - - - 0.000000000000004626 85.0
TLS2_k127_6865354_12 DNA-binding transcriptional activator of the SARP family - - - 0.00000000002952 78.0
TLS2_k127_6865354_2 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 454.0
TLS2_k127_6865354_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 359.0
TLS2_k127_6865354_4 dephospho-CoA kinase activity K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000005387 263.0
TLS2_k127_6865354_5 lactate racemase activity - - - 0.0000000000000000000000000000000000000000000000000005117 203.0
TLS2_k127_6865354_6 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.00000000000000000000000000000000000000002967 166.0
TLS2_k127_6865354_7 Cupin domain - - - 0.00000000000000000000000000000000000000004464 167.0
TLS2_k127_6865354_8 acetyltransferase K15520 - 2.3.1.189 0.0000000000000000000000000000000000000002069 155.0
TLS2_k127_6865354_9 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000001233 151.0
TLS2_k127_6867388_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.172e-224 705.0
TLS2_k127_6867388_1 aminotransferase class I and II K10907 - - 2.954e-208 658.0
TLS2_k127_6867388_2 Domain of unknown function (DUF4037) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008117 383.0
TLS2_k127_6867388_3 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 337.0
TLS2_k127_6867388_4 PFAM Patatin K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005378 279.0
TLS2_k127_6867388_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000001374 132.0
TLS2_k127_6867388_6 peptidase activity K01286 - 3.4.16.4 0.00000000005142 75.0
TLS2_k127_6871263_0 ABC-type sugar transport system, permease component K02026 - - 3.021e-197 633.0
TLS2_k127_6871263_1 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 547.0
TLS2_k127_6871263_10 subunit of a heme lyase K02200 - - 0.00000000000000000000000000000000000000000000726 170.0
TLS2_k127_6871263_11 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000000759 165.0
TLS2_k127_6871263_12 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000003495 147.0
TLS2_k127_6871263_13 NmrA-like family K00091 - 1.1.1.219 0.0000000000000000000000000000000000009947 153.0
TLS2_k127_6871263_14 phosphoribosyl-ATP pyrophosphohydrolase - - - 0.00000000000000000000000002838 111.0
TLS2_k127_6871263_2 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 506.0
TLS2_k127_6871263_3 FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009756 471.0
TLS2_k127_6871263_4 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 472.0
TLS2_k127_6871263_5 Extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 334.0
TLS2_k127_6871263_6 aldo keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 325.0
TLS2_k127_6871263_7 PFAM peptidase M22 glycoprotease K14742 - - 0.00000000000000000000000000000000000000000000000000000001999 207.0
TLS2_k127_6871263_8 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000000000002335 189.0
TLS2_k127_6871263_9 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.00000000000000000000000000000000000000000000005554 175.0
TLS2_k127_6875077_0 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006284 474.0
TLS2_k127_6875077_1 Amino-transferase class IV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 389.0
TLS2_k127_6875077_10 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000002031 136.0
TLS2_k127_6875077_11 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000006412 84.0
TLS2_k127_6875077_12 PFAM Alcohol dehydrogenase, zinc-binding K18369 - - 0.0000000000000000127 94.0
TLS2_k127_6875077_13 Extracellular solute-binding protein K02027 - - 0.000001353 61.0
TLS2_k127_6875077_14 DNA helicase - - - 0.00001395 55.0
TLS2_k127_6875077_15 hyperosmotic response - - - 0.0002295 48.0
TLS2_k127_6875077_2 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 363.0
TLS2_k127_6875077_3 Peptide ABC transporter permease K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 322.0
TLS2_k127_6875077_4 succinylglutamate desuccinylase aspartoacylase K06987,K15784 - 3.5.1.125 0.000000000000000000000000000000000000000000000000000002033 203.0
TLS2_k127_6875077_5 Binding-protein-dependent transport system inner membrane component K02025,K05814,K17242 - - 0.00000000000000000000000000000000000000000000000000151 196.0
TLS2_k127_6875077_6 membrane - - - 0.000000000000000000000000000000000000000000000003158 179.0
TLS2_k127_6875077_7 Binding-protein-dependent transport system inner membrane component K10202,K17239 - - 0.0000000000000000000000000000000000000000009522 168.0
TLS2_k127_6875077_8 PhoQ Sensor K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000004876 156.0
TLS2_k127_6875077_9 Bacterial periplasmic substrate-binding proteins K02030 - - 0.00000000000000000000000000000000000115 149.0
TLS2_k127_6904559_0 melibiose metabolic process K01222,K07406 - 3.2.1.22,3.2.1.86 1.391e-221 694.0
TLS2_k127_6904559_1 COGs COG0488 ATPase components of ABC transporter with duplicated ATPase domains K06158,K18230 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 515.0
TLS2_k127_6904559_2 aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008141 430.0
TLS2_k127_6904559_3 PFAM cyclase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 411.0
TLS2_k127_6904559_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000003593 231.0
TLS2_k127_6904559_5 Transposase K07494 - - 0.000000000000000000000000000000000000000000000000000000002044 207.0
TLS2_k127_6904559_6 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.000000000000000000000000000000000000000004665 157.0
TLS2_k127_6904559_7 transcriptional regulator - - - 0.000019 51.0
TLS2_k127_6939232_0 Tn3 transposase DDE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 542.0
TLS2_k127_6939232_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 456.0
TLS2_k127_6939232_10 sh3 domain protein K12132,K15539 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000002652 223.0
TLS2_k127_6939232_11 Sulfate ABC transporter periplasmic sulfate-binding protein K02048 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000007116 203.0
TLS2_k127_6939232_12 ATPase-coupled sulfate transmembrane transporter activity K02046,K02047 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000001415 194.0
TLS2_k127_6939232_13 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000000000000000005841 155.0
TLS2_k127_6939232_14 Belongs to the bacterial ribosomal protein bL33 family K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000001919 96.0
TLS2_k127_6939232_15 Belongs to the universal stress protein A family - - - 0.000000000000000000002057 99.0
TLS2_k127_6939232_16 Tn3 transposase DDE domain - - - 0.000000000000000000004778 96.0
TLS2_k127_6939232_17 - - - - 0.0000000426 57.0
TLS2_k127_6939232_2 ATPase activity K02045 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 473.0
TLS2_k127_6939232_3 histidine biosynthetic process K00765,K01892,K02502 - 2.4.2.17,6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 363.0
TLS2_k127_6939232_4 Tn3 transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 337.0
TLS2_k127_6939232_5 sh3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 346.0
TLS2_k127_6939232_6 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 319.0
TLS2_k127_6939232_7 Resolvase, N terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 287.0
TLS2_k127_6939232_8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity K00765,K02502 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 284.0
TLS2_k127_6939232_9 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000003333 250.0
TLS2_k127_6965846_0 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 472.0
TLS2_k127_6965846_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006522 432.0
TLS2_k127_6965846_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005179 405.0
TLS2_k127_6965846_3 Belongs to the ABC transporter superfamily K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008547 402.0
TLS2_k127_6965846_4 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 395.0
TLS2_k127_6965846_5 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 302.0
TLS2_k127_6965846_6 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain K01856,K01860 - 5.5.1.1,5.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000008124 250.0
TLS2_k127_6965846_7 Dehydrogenase - - - 0.00000000000000000000000000000000000002054 157.0
TLS2_k127_6966638_0 4Fe-4S dicluster domain K00184 - - 0.0 1163.0
TLS2_k127_6966638_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 8.757e-265 827.0
TLS2_k127_6966638_10 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000000001497 205.0
TLS2_k127_6966638_11 PFAM magnesium chelatase ChlI subunit K07391 - - 0.00000000000000000000172 94.0
TLS2_k127_6966638_12 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000000000000000004981 90.0
TLS2_k127_6966638_14 - - - - 0.0000001997 62.0
TLS2_k127_6966638_15 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.00003726 47.0
TLS2_k127_6966638_2 Polysulphide reductase, NrfD K00185 - - 5.135e-218 685.0
TLS2_k127_6966638_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008382 359.0
TLS2_k127_6966638_4 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 342.0
TLS2_k127_6966638_5 ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006179 330.0
TLS2_k127_6966638_6 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 289.0
TLS2_k127_6966638_7 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007167 269.0
TLS2_k127_6966638_8 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000248 225.0
TLS2_k127_6966638_9 cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000008194 214.0
TLS2_k127_6973673_0 TIGRFAM FeS assembly protein SufB K07033,K09014 - - 4.853e-285 878.0
TLS2_k127_6973673_1 Putative glucoamylase K13688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004381 268.0
TLS2_k127_6973673_2 Protein of unknown function (DUF3494) K11904 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003101 258.0
TLS2_k127_6973673_3 - - - - 0.00000000000000000000000000000002004 132.0
TLS2_k127_6973673_4 PFAM regulatory protein LuxR - - - 0.00000000000000000000000002275 118.0
TLS2_k127_6973673_5 PFAM UspA domain protein - - - 0.0000000000000000000000001726 118.0
TLS2_k127_6973673_6 YGGT family - - - 0.00000000000000004364 87.0
TLS2_k127_6995562_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1429.0
TLS2_k127_6995562_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 6.87e-205 647.0
TLS2_k127_6995562_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007062 262.0
TLS2_k127_6995562_3 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.000000000000000000000000000000000000002175 152.0
TLS2_k127_6995562_4 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0000000000000000000000000000002895 128.0
TLS2_k127_6995562_5 N-ATPase, AtpR subunit - - - 0.000000000000000008087 87.0
TLS2_k127_6997693_0 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 1.459e-226 716.0
TLS2_k127_6997693_1 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 1.152e-213 682.0
TLS2_k127_7013493_0 Spermine/spermidine synthase domain - - - 3.002e-195 621.0
TLS2_k127_7013493_1 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004104 291.0
TLS2_k127_7013493_2 response regulator K07669 - - 0.00000000000000000000000000000000000000000000000000000000001104 213.0
TLS2_k127_7013493_3 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000002948 191.0
TLS2_k127_7013493_4 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000008353 150.0
TLS2_k127_7013493_5 Ferritin-like domain K03594 - 1.16.3.1 0.000000000000000000004894 94.0
TLS2_k127_7013493_6 CsbD-like - - - 0.00000000000000000004794 94.0
TLS2_k127_7013493_7 UPF0391 membrane protein - - - 0.000000000000002283 78.0
TLS2_k127_7013493_8 DUF35 OB-fold domain, acyl-CoA-associated K07068,K07549 - - 0.0000000004926 64.0
TLS2_k127_7013493_9 Single Cache domain 2 K02480 - 2.7.13.3 0.000018 57.0
TLS2_k127_7019839_0 arylsulfatase activity - - - 2.602e-229 720.0
TLS2_k127_7019839_1 Fructose-bisphosphate aldolase class-II - - - 3.745e-217 682.0
TLS2_k127_7019839_10 - - - - 0.000000000000000000000000000000000000000000000000000000001192 229.0
TLS2_k127_7019839_11 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000000000000000000000000000000000000000002767 188.0
TLS2_k127_7019839_12 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000004138 174.0
TLS2_k127_7019839_13 Sucrose-6F-phosphate phosphohydrolase - - - 0.00000000000000000000000000000000003856 146.0
TLS2_k127_7019839_14 - - - - 0.00000000000000000000000004435 123.0
TLS2_k127_7019839_15 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000003199 109.0
TLS2_k127_7019839_16 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.000000000000000000004166 98.0
TLS2_k127_7019839_17 Transcriptional regulator - - - 0.000000000001173 82.0
TLS2_k127_7019839_18 NADH ubiquinone oxidoreductase subunit 5 (Chain L) multisubunit Na H antiporter, MnhA subunit K05565 GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 0.00003033 53.0
TLS2_k127_7019839_2 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 418.0
TLS2_k127_7019839_3 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 394.0
TLS2_k127_7019839_4 maltose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006183 411.0
TLS2_k127_7019839_5 PFAM oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 325.0
TLS2_k127_7019839_6 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000381 314.0
TLS2_k127_7019839_7 helix_turn_helix, Lux Regulon K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001222 299.0
TLS2_k127_7019839_8 cellular water homeostasis K05802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000857 276.0
TLS2_k127_7019839_9 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000002563 220.0
TLS2_k127_7037947_0 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 480.0
TLS2_k127_7037947_1 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 456.0
TLS2_k127_7037947_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 441.0
TLS2_k127_7037947_3 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000003855 227.0
TLS2_k127_7037947_4 GNAT acetyltransferase - - - 0.0000000000484 72.0
TLS2_k127_7037947_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00005135 49.0
TLS2_k127_704379_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 451.0
TLS2_k127_704379_1 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 330.0
TLS2_k127_704379_2 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000004866 115.0
TLS2_k127_70518_0 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 5.151e-212 666.0
TLS2_k127_70518_1 PFAM alanine dehydrogenase PNT domain protein K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 528.0
TLS2_k127_70518_2 Domain of unknown function (DUF4160) - - - 0.000000000001943 74.0
TLS2_k127_70518_4 Protein of unknown function (DUF2442) - - - 0.0001485 45.0
TLS2_k127_7056963_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 2.153e-304 952.0
TLS2_k127_7056963_1 Psort location CytoplasmicMembrane, score - - - 4.312e-261 838.0
TLS2_k127_7056963_10 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005332 259.0
TLS2_k127_7056963_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000001663 216.0
TLS2_k127_7056963_12 PFAM Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000002954 188.0
TLS2_k127_7056963_13 transmembrane transport K02025,K05814,K10118,K10237,K15771,K17235,K17238,K17316 - - 0.000000000000000000000000000000000000000000000004298 184.0
TLS2_k127_7056963_14 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000003481 141.0
TLS2_k127_7056963_15 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000005719 110.0
TLS2_k127_7056963_2 succinate dehydrogenase - - - 1.367e-257 802.0
TLS2_k127_7056963_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 599.0
TLS2_k127_7056963_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000975 528.0
TLS2_k127_7056963_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 511.0
TLS2_k127_7056963_6 carbohydrate transport K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 474.0
TLS2_k127_7056963_7 PFAM binding-protein-dependent transport systems inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 322.0
TLS2_k127_7056963_8 glycerophosphodiester transmembrane transport K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 313.0
TLS2_k127_7056963_9 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005325 273.0
TLS2_k127_7108711_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 383.0
TLS2_k127_7108711_1 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 392.0
TLS2_k127_7108711_2 xyloglucan:xyloglucosyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 344.0
TLS2_k127_7108711_3 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 319.0
TLS2_k127_7108711_4 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000001901 164.0
TLS2_k127_7108711_5 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000004163 134.0
TLS2_k127_7108711_6 DDE superfamily endonuclease - - - 0.0000000000000000001074 96.0
TLS2_k127_7108711_7 COG5640 Secreted trypsin-like serine protease - - - 0.0000000000000000008435 96.0
TLS2_k127_7108711_8 Transposase - - - 0.00001614 53.0
TLS2_k127_7113543_0 Protein of unknown function, DUF255 K06888 - - 0.0 1035.0
TLS2_k127_7113543_1 Lytic transglycosylase catalytic K08309 - - 2.19e-272 864.0
TLS2_k127_7113543_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.759e-241 754.0
TLS2_k127_7113543_3 fructose 1,6-bisphosphate 1-phosphatase activity K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 541.0
TLS2_k127_7113543_4 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K22319 - 6.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 538.0
TLS2_k127_7113543_5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005227 252.0
TLS2_k127_7113543_6 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000001423 131.0
TLS2_k127_7113543_7 acetyltransferase - - - 0.0000000000000000000000001178 108.0
TLS2_k127_7113543_8 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000000005428 98.0
TLS2_k127_7113543_9 aminopeptidase activity K07004 - - 0.0000000000000003795 92.0
TLS2_k127_7159765_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 7.412e-237 745.0
TLS2_k127_7159765_1 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005431 553.0
TLS2_k127_7159765_10 Domain of unknown function (DUF4349) - - - 0.0000000000000000000000132 112.0
TLS2_k127_7159765_11 protein containing double-stranded beta helix domain - - - 0.000000000000000005772 95.0
TLS2_k127_7159765_2 Aminotransferase K00813,K00832 GO:0003674,GO:0003824,GO:0004069,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.6.1.1,2.6.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 545.0
TLS2_k127_7159765_3 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 353.0
TLS2_k127_7159765_4 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 310.0
TLS2_k127_7159765_5 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000002284 235.0
TLS2_k127_7159765_6 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000006813 227.0
TLS2_k127_7159765_8 - - - - 0.0000000000000000000000000000000006105 137.0
TLS2_k127_7159765_9 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000001148 121.0
TLS2_k127_7168930_0 NurA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005252 398.0
TLS2_k127_7168930_1 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008764 289.0
TLS2_k127_7168930_2 Peptidase family M28 K05994 - 3.4.11.10 0.0000000000000000000000000000215 137.0
TLS2_k127_7173029_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 0.0 1064.0
TLS2_k127_7173029_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 5.135e-286 889.0
TLS2_k127_7173029_10 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 289.0
TLS2_k127_7173029_11 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000007797 241.0
TLS2_k127_7173029_12 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.000000000000000000000000000000000000000000000000000000000000003585 224.0
TLS2_k127_7173029_13 Methyltransferase domain - - - 0.0000000000000000000000000000000002366 139.0
TLS2_k127_7173029_14 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000004858 134.0
TLS2_k127_7173029_15 - - - - 0.0000005918 61.0
TLS2_k127_7173029_16 Cupin 2, conserved barrel domain protein - - - 0.0004482 48.0
TLS2_k127_7173029_2 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 1.657e-237 747.0
TLS2_k127_7173029_3 Peptidase dimerisation domain protein K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 550.0
TLS2_k127_7173029_4 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 532.0
TLS2_k127_7173029_5 PFAM Rh family protein ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 473.0
TLS2_k127_7173029_6 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 415.0
TLS2_k127_7173029_7 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 379.0
TLS2_k127_7173029_8 helicase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 285.0
TLS2_k127_7173029_9 FCD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 288.0
TLS2_k127_7198248_0 Phage tail sheath C-terminal domain K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 502.0
TLS2_k127_7198248_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 491.0
TLS2_k127_7198248_10 - - - - 0.000000000000000201 79.0
TLS2_k127_7198248_11 phage tail - - - 0.00000000009101 70.0
TLS2_k127_7198248_2 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 488.0
TLS2_k127_7198248_3 carboxylic acid catabolic process K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000009037 244.0
TLS2_k127_7198248_4 - - - - 0.0000000000000000000000000000000000000004463 151.0
TLS2_k127_7198248_5 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000001477 140.0
TLS2_k127_7198248_6 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000008577 139.0
TLS2_k127_7198248_7 Protein of unknown function (DUF4255) - - - 0.0000000000000000000000006964 115.0
TLS2_k127_7198248_8 PFAM CBS domain containing protein K04767 - - 0.0000000000000000000008259 100.0
TLS2_k127_7198248_9 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000832 97.0
TLS2_k127_7214472_0 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 614.0
TLS2_k127_7214472_1 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007451 386.0
TLS2_k127_7214472_2 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 319.0
TLS2_k127_7214472_3 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 311.0
TLS2_k127_7214472_4 Protein phosphatase 2C - - - 0.0000000000000000000000000000000000000000000000000000000008168 213.0
TLS2_k127_7214472_5 cellular response to dsDNA K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000004564 212.0
TLS2_k127_7214472_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000126 155.0
TLS2_k127_7214472_7 Enoyl-(Acyl carrier protein) reductase - - - 0.0003575 48.0
TLS2_k127_7217646_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1024.0
TLS2_k127_7217646_1 L-malate dehydrogenase activity K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 538.0
TLS2_k127_7217646_2 Major facilitator superfamily MFS_1 K08161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 469.0
TLS2_k127_7217646_3 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003915 269.0
TLS2_k127_7217646_5 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000001201 235.0
TLS2_k127_7217646_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000002581 201.0
TLS2_k127_7217646_7 LysM domain K12204 - - 0.0000000000000000000000000000000000000000005433 175.0
TLS2_k127_7305568_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.592e-225 704.0
TLS2_k127_7305568_1 domain protein K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006 351.0
TLS2_k127_7305568_2 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000194 211.0
TLS2_k127_7305568_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000000001143 154.0
TLS2_k127_7306331_0 carboxylic ester hydrolase activity K15357 - 3.5.1.106 0.000000000000000000000000000000000000000000000000000003988 201.0
TLS2_k127_7306331_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000001103 160.0
TLS2_k127_7306331_3 - - - - 0.0000000000000000000000001099 108.0
TLS2_k127_7306331_4 transposase activity - - - 0.0000000000000000008273 94.0
TLS2_k127_7306331_5 - - - - 0.0000000000001431 74.0
TLS2_k127_731255_0 Domain of unknown function (DUF5060) - - - 1.054e-225 709.0
TLS2_k127_731255_1 PFAM Mandelate racemase muconate lactonizing enzyme, N-terminal domain protein K01684 - 4.2.1.6 1.374e-221 690.0
TLS2_k127_731255_10 PFAM Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000005438 226.0
TLS2_k127_731255_11 carbohydrate transport K02027,K10117 - - 0.0000000000000000000000000000000000000000000000000000000000113 223.0
TLS2_k127_731255_12 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000001684 169.0
TLS2_k127_731255_14 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000006118 116.0
TLS2_k127_731255_15 Transcriptional regulatory protein, C terminal - - - 0.0000000385 66.0
TLS2_k127_731255_16 Demethylmenaquinone methyltransferase - - - 0.0006651 43.0
TLS2_k127_731255_2 Mandelate racemase muconate K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 539.0
TLS2_k127_731255_3 Mandelate racemase muconate lactonizing enzyme K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006337 426.0
TLS2_k127_731255_4 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 419.0
TLS2_k127_731255_6 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 304.0
TLS2_k127_731255_7 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001504 283.0
TLS2_k127_731255_8 binding-protein-dependent transport systems inner membrane component K02026,K10242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006089 267.0
TLS2_k127_731255_9 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002384 240.0
TLS2_k127_7318493_0 AAA ATPase domain - - - 0.0 1827.0
TLS2_k127_7318493_1 Heavy-metal-associated domain K17686 - 3.6.3.54 5.228e-314 975.0
TLS2_k127_7318493_10 PFAM Transketolase central region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 533.0
TLS2_k127_7318493_11 PFAM dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 470.0
TLS2_k127_7318493_12 protein import - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 436.0
TLS2_k127_7318493_13 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 365.0
TLS2_k127_7318493_14 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 325.0
TLS2_k127_7318493_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 338.0
TLS2_k127_7318493_17 imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 296.0
TLS2_k127_7318493_18 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 292.0
TLS2_k127_7318493_19 PFAM NUDIX hydrolase K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002064 284.0
TLS2_k127_7318493_2 Tn3 transposase DDE domain - - - 1.118e-305 953.0
TLS2_k127_7318493_20 IS630 family ISRj1-like transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000119 273.0
TLS2_k127_7318493_21 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001734 276.0
TLS2_k127_7318493_22 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003507 267.0
TLS2_k127_7318493_23 Belongs to the pseudouridine synthase RsuA family K06178,K06181 - 5.4.99.20,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000003994 269.0
TLS2_k127_7318493_24 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001393 266.0
TLS2_k127_7318493_25 protein import - - - 0.0000000000000000000000000000000000000000000000000000000000000000001139 239.0
TLS2_k127_7318493_26 Resolvase, N terminal domain - - - 0.000000000000000000000000000000000000000000000000000005823 198.0
TLS2_k127_7318493_27 Transposase - - - 0.00000000000000000000000000000000000000000000000006061 184.0
TLS2_k127_7318493_28 L-rhamnose mutarotase K03534 - 5.1.3.32 0.0000000000000000000000000000000000000000000243 166.0
TLS2_k127_7318493_29 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000001519 162.0
TLS2_k127_7318493_3 Berberine and berberine like - - - 1.3e-282 871.0
TLS2_k127_7318493_30 Transposase K07497 - - 0.0000000000000000000000000000000009496 134.0
TLS2_k127_7318493_31 - - - - 0.0000000000000000000000000000000009578 143.0
TLS2_k127_7318493_32 Putative regulatory protein - - - 0.000000000000001808 78.0
TLS2_k127_7318493_33 Putative restriction endonuclease - - - 0.000000000000004392 84.0
TLS2_k127_7318493_34 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000002701 67.0
TLS2_k127_7318493_35 COG2801 Transposase and inactivated derivatives K07497 - - 0.00000000563 60.0
TLS2_k127_7318493_36 Berberine and berberine like - - - 0.000000006811 60.0
TLS2_k127_7318493_37 Transposase IS66 family - - - 0.00000004199 57.0
TLS2_k127_7318493_38 Transposase IS66 family - - - 0.0000001514 56.0
TLS2_k127_7318493_39 Winged helix DNA-binding domain - - - 0.000004491 55.0
TLS2_k127_7318493_4 Catalyzes the conversion of L-arabinose to L-ribulose K01804 - 5.3.1.4 1.12e-207 655.0
TLS2_k127_7318493_5 N-acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 1.481e-197 629.0
TLS2_k127_7318493_6 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 566.0
TLS2_k127_7318493_7 Acyl-CoA dehydrogenase, C-terminal domain K16047 - 1.14.14.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000847 559.0
TLS2_k127_7318493_8 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 543.0
TLS2_k127_7318493_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 541.0
TLS2_k127_7321041_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 1.027e-262 819.0
TLS2_k127_7321041_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008266 510.0
TLS2_k127_7321041_10 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003339 279.0
TLS2_k127_7321041_11 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001336 268.0
TLS2_k127_7321041_12 positive regulation of macromolecule biosynthetic process K03973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003964 257.0
TLS2_k127_7321041_13 Uncharacterized conserved protein (COG2071) K09166 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005311 249.0
TLS2_k127_7321041_14 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000000000000000000000000001062 191.0
TLS2_k127_7321041_15 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000001622 148.0
TLS2_k127_7321041_16 response regulator K07689 - - 0.000000000000000000000000000000000008333 139.0
TLS2_k127_7321041_18 sigma-70 region 2 domain protein K03088 - - 0.0000000000000000007781 86.0
TLS2_k127_7321041_19 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000798 74.0
TLS2_k127_7321041_2 Protein of unknown function (DUF3419) K13622 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007305 423.0
TLS2_k127_7321041_3 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 414.0
TLS2_k127_7321041_4 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009066 415.0
TLS2_k127_7321041_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 404.0
TLS2_k127_7321041_6 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 352.0
TLS2_k127_7321041_7 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 334.0
TLS2_k127_7321041_8 dolichyl monophosphate biosynthetic process K00981,K18678 - 2.7.1.182,2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 320.0
TLS2_k127_7321041_9 Pyridine nucleotide-disulphide oxidoreductase K03387 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 311.0
TLS2_k127_7328715_0 PFAM IstB domain protein ATP-binding protein K02315 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 591.0
TLS2_k127_7328715_1 PFAM DNA polymerase, beta domain protein region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009185 382.0
TLS2_k127_7328715_2 TIGRFAM primosome, DnaD subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 339.0
TLS2_k127_7328715_3 sh3 domain protein K01448,K04771 - 3.4.21.107,3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000009941 244.0
TLS2_k127_734649_0 ATPases associated with a variety of cellular activities K16786,K16787 - - 1.001e-214 681.0
TLS2_k127_734649_1 Prenyltransferase and squalene oxidase repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 392.0
TLS2_k127_734649_10 Ferredoxin - - - 0.000000000000000000000000000000000000000000000005112 177.0
TLS2_k127_734649_11 PFAM Prenyltransferase squalene oxidase - - - 0.0000000000000000000000000000000000000000000006919 186.0
TLS2_k127_734649_12 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000001027 152.0
TLS2_k127_734649_13 translation initiation factor activity K16637 - - 0.00000000000000009528 93.0
TLS2_k127_734649_14 COG1226 Kef-type K transport systems - - - 0.0000000878 56.0
TLS2_k127_734649_2 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 341.0
TLS2_k127_734649_3 ECF transporter, substrate-specific component K16927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 334.0
TLS2_k127_734649_4 PFAM Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 301.0
TLS2_k127_734649_5 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 292.0
TLS2_k127_734649_6 Cobalt transport protein K16785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001009 288.0
TLS2_k127_734649_7 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000001338 243.0
TLS2_k127_734649_8 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000003094 233.0
TLS2_k127_734649_9 PFAM cobalbumin biosynthesis protein K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000000000000000000000003123 218.0
TLS2_k127_7355648_0 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0 1207.0
TLS2_k127_7355648_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0 1155.0
TLS2_k127_7355648_10 Ribosomal L27 protein K02899 - - 0.000000000000000000000000000000000004443 139.0
TLS2_k127_7355648_11 Histidine Phosphotransfer domain - - - 0.00000008338 58.0
TLS2_k127_7355648_2 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005088 524.0
TLS2_k127_7355648_3 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 350.0
TLS2_k127_7355648_4 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 341.0
TLS2_k127_7355648_5 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 - 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 319.0
TLS2_k127_7355648_6 PFAM thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005611 297.0
TLS2_k127_7355648_7 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000000000000000000000000001691 183.0
TLS2_k127_7355648_8 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000000000000000001003 160.0
TLS2_k127_7361915_0 WD-40 repeat-containing protein K12132 - 2.7.11.1 3.28e-200 689.0
TLS2_k127_7361915_1 Caspase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 486.0
TLS2_k127_7361915_2 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 393.0
TLS2_k127_7361915_3 DNA-binding transcription factor activity K03892 - - 0.000000000000000000000000000000000000000000000000000000000000000000009135 241.0
TLS2_k127_7361915_4 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000001066 209.0
TLS2_k127_7371094_0 SMART PDZ DHR GLGF domain protein K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 549.0
TLS2_k127_7371094_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 511.0
TLS2_k127_7371094_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 444.0
TLS2_k127_7371094_3 PFAM Auxin Efflux Carrier K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 307.0
TLS2_k127_7371094_4 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001386 292.0
TLS2_k127_7371094_5 PFAM aspartate glutamate uridylate kinase K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000001405 259.0
TLS2_k127_7371094_6 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000001591 194.0
TLS2_k127_7371094_7 LysM domain - - - 0.0000000000000000000000000000000000000000002532 177.0
TLS2_k127_7373344_0 tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 2.415e-246 765.0
TLS2_k127_7373344_1 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008671 469.0
TLS2_k127_7373344_2 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 437.0
TLS2_k127_7373344_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000001485 250.0
TLS2_k127_7373344_4 LysM domain - - - 0.0000000000000000000000000000000000000000000000000001485 195.0
TLS2_k127_7373538_0 Family 4 glycosyl hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 539.0
TLS2_k127_7373538_1 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 462.0
TLS2_k127_7373538_2 Sulfotransferase domain - - - 0.00000000000000000000000000000000000000000000008972 173.0
TLS2_k127_7373538_3 - - - - 0.0000000000000000000000000000000000000000001804 161.0
TLS2_k127_7373538_4 InterPro IPR007367 - - - 0.0000000000000000000000000002122 116.0
TLS2_k127_7373538_5 - - - - 0.0001803 53.0
TLS2_k127_7394191_0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 3.112e-250 799.0
TLS2_k127_7394191_1 ATPase family associated with various cellular activities (AAA) - - - 2.015e-237 742.0
TLS2_k127_7394191_2 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 469.0
TLS2_k127_7394191_3 (ABC) transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008501 422.0
TLS2_k127_7394191_5 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000005227 214.0
TLS2_k127_7394191_6 Methyltransferase small domain - - - 0.00000000000000000000000000000000000000000000000000000002154 207.0
TLS2_k127_7394191_7 PHP domain protein K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000001396 168.0
TLS2_k127_7424158_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00113 - 1.1.5.3 4.89e-220 689.0
TLS2_k127_7424158_1 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00112 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 407.0
TLS2_k127_7424158_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 299.0
TLS2_k127_7424158_3 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000000000000000000000000000000000003185 235.0
TLS2_k127_7424158_4 Hit family K02503 - - 0.00000000000000000000000000002865 121.0
TLS2_k127_7424158_5 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.000002137 51.0
TLS2_k127_7437828_0 Binding-protein-dependent transport system inner membrane component K02025,K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 482.0
TLS2_k127_7437828_1 Extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000004991 244.0
TLS2_k127_7437828_2 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000004211 209.0
TLS2_k127_7467691_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169,K03737 - 1.2.7.1 0.0 1776.0
TLS2_k127_7467691_1 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 501.0
TLS2_k127_7467691_2 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 403.0
TLS2_k127_7467691_3 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000000000000000000000000000000001108 166.0
TLS2_k127_7467691_4 TPR repeat - - - 0.000000002838 69.0
TLS2_k127_7467691_5 intracellular signal transduction - - - 0.00001508 51.0
TLS2_k127_7468542_0 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 560.0
TLS2_k127_7468542_1 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 473.0
TLS2_k127_7468542_10 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001177 273.0
TLS2_k127_7468542_11 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001346 268.0
TLS2_k127_7468542_12 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007462 252.0
TLS2_k127_7468542_13 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001586 252.0
TLS2_k127_7468542_14 catechol 1,2-dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000002067 230.0
TLS2_k127_7468542_15 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000008936 213.0
TLS2_k127_7468542_16 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000000000000000000000111 211.0
TLS2_k127_7468542_17 PFAM MOFRL domain protein K11529 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114 2.7.1.165 0.0000000000000000000000000000000000000000000000000000009488 211.0
TLS2_k127_7468542_18 riboflavin synthase alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.000000000000000000000000000000000000000000000000000003373 201.0
TLS2_k127_7468542_19 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000003682 196.0
TLS2_k127_7468542_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 413.0
TLS2_k127_7468542_20 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.0000000000000000000000000000000000000000000000000004017 190.0
TLS2_k127_7468542_21 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000006874 183.0
TLS2_k127_7468542_22 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.00000000000000000000000000000000000000000000000001698 183.0
TLS2_k127_7468542_23 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000001662 146.0
TLS2_k127_7468542_24 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.0000000000000000000000000000008391 126.0
TLS2_k127_7468542_25 Belongs to the UPF0312 family - - - 0.00000000000000000000000000001773 128.0
TLS2_k127_7468542_27 Predicted membrane protein (DUF2339) - - - 0.000000000001126 72.0
TLS2_k127_7468542_28 - - - - 0.00001391 55.0
TLS2_k127_7468542_29 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00005159 46.0
TLS2_k127_7468542_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K18983 - 5.1.2.2,5.5.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 337.0
TLS2_k127_7468542_4 PHP domain K04486 - 3.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 325.0
TLS2_k127_7468542_5 Belongs to the Nudix hydrolase family. NudC subfamily K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006878 307.0
TLS2_k127_7468542_6 dehydrogenases and related proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 303.0
TLS2_k127_7468542_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009167 290.0
TLS2_k127_7468542_8 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000421 278.0
TLS2_k127_7468542_9 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004554 272.0
TLS2_k127_7470555_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 4.585e-198 634.0
TLS2_k127_7470555_1 short-chain dehydrogenase reductase SDR K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005398 362.0
TLS2_k127_7470555_2 glycosyl - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 338.0
TLS2_k127_7471378_0 Uncharacterised protein family (UPF0261) - - - 1.978e-200 631.0
TLS2_k127_7471378_1 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 620.0
TLS2_k127_7471378_10 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 300.0
TLS2_k127_7471378_11 Regulatory protein GntR HTH - - - 0.00000000000000000000000000000000000000000000000000000000000000002274 232.0
TLS2_k127_7471378_12 - - - - 0.00000000000000000000000000000000000000000000000005898 203.0
TLS2_k127_7471378_13 acetyltransferase K00639,K00652,K13614,K15674 - 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000007813 164.0
TLS2_k127_7471378_14 Cupin - - - 0.0000000000000000000000000003426 118.0
TLS2_k127_7471378_15 domain, Protein - - - 0.0000000000000000008381 102.0
TLS2_k127_7471378_16 nitrogen compound transport K00759,K02033 - 2.4.2.7 0.000000000000000615 80.0
TLS2_k127_7471378_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 453.0
TLS2_k127_7471378_3 Phosphoenolpyruvate hydrolase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 434.0
TLS2_k127_7471378_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 421.0
TLS2_k127_7471378_5 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 409.0
TLS2_k127_7471378_6 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 388.0
TLS2_k127_7471378_7 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009638 385.0
TLS2_k127_7471378_8 PFAM extracellular solute-binding protein family 1 K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 358.0
TLS2_k127_7471378_9 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 320.0
TLS2_k127_7751_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 5.319e-262 822.0
TLS2_k127_7751_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 9.836e-230 720.0
TLS2_k127_7751_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 531.0
TLS2_k127_7751_3 DNA-templated transcription, initiation K03088,K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000002025 251.0
TLS2_k127_7751_4 Ferredoxin - - - 0.00000000000000000000000000000000000002149 147.0
TLS2_k127_7751_5 - - - - 0.0000000000000000003095 93.0
TLS2_k127_776105_0 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 632.0
TLS2_k127_776105_1 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005537 587.0
TLS2_k127_776105_10 - - - - 0.00000000000004069 74.0
TLS2_k127_776105_2 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000003556 215.0
TLS2_k127_776105_3 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000000000000000000000000000000000000000003336 203.0
TLS2_k127_776105_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000008271 205.0
TLS2_k127_776105_5 - - - - 0.0000000000000000000000000000000000000000000000000002566 192.0
TLS2_k127_776105_6 Malate/L-lactate dehydrogenase K00073 - 1.1.1.350 0.0000000000000000000000000000000000000000000001183 181.0
TLS2_k127_776105_7 - - - - 0.0000000000000000000000000000004152 131.0
TLS2_k127_776105_8 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000000000000001087 105.0
TLS2_k127_78239_0 binding-protein-dependent transport systems inner membrane component K17319 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 306.0
TLS2_k127_78239_1 binding-protein-dependent transport systems inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000001179 246.0
TLS2_k127_78239_2 KR domain K00076 - 1.1.1.159 0.0000000000000000000000000000000000000000000000000000002723 203.0
TLS2_k127_78239_3 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000001029 148.0
TLS2_k127_78239_4 palmitoyl-(protein) hydrolase activity K06999 - - 0.000000002321 70.0
TLS2_k127_78239_5 D-mannonate dehydratase (UxuA) K01686 - 4.2.1.8 0.000009884 51.0
TLS2_k127_78239_6 - - - - 0.00004063 56.0
TLS2_k127_794918_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 4.478e-291 899.0
TLS2_k127_794918_1 Belongs to the aldehyde dehydrogenase family - - - 1.102e-203 644.0
TLS2_k127_794918_10 sequence-specific DNA binding K03718,K03719 - - 0.0000000000000000000000000000000000000000000000000000000000001324 218.0
TLS2_k127_794918_11 pyridoxal biosynthesis protein K08681 GO:0003674,GO:0003824,GO:0004359,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0046982,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000008928 218.0
TLS2_k127_794918_12 CoA carboxylase activity K01965,K02160 - 6.4.1.3 0.00000000000000000000000000000000000000000000000000000007158 200.0
TLS2_k127_794918_13 Protein of unknown function (DUF4013) - - - 0.00000000000000000000000000000000000000000000000004437 190.0
TLS2_k127_794918_14 domain, Protein - - - 0.0000000000000000000000000000000000000000000000002184 191.0
TLS2_k127_794918_15 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000456 184.0
TLS2_k127_794918_16 Histidine kinase - - - 0.00000000000000000000000000000000000000001598 171.0
TLS2_k127_794918_18 Protein of unknown function (DUF1405) - - - 0.00000000000000001937 92.0
TLS2_k127_794918_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 567.0
TLS2_k127_794918_3 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 533.0
TLS2_k127_794918_4 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 503.0
TLS2_k127_794918_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 390.0
TLS2_k127_794918_6 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 346.0
TLS2_k127_794918_7 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 320.0
TLS2_k127_794918_8 Binding-protein-dependent transport system inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 299.0
TLS2_k127_798953_0 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005588 441.0
TLS2_k127_798953_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 - 6.1.1.16,6.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 411.0
TLS2_k127_798953_2 translation release factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 347.0
TLS2_k127_798953_3 Sulfatase-modifying factor enzyme 1 K13444 - 1.8.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000003601 264.0
TLS2_k127_798953_4 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000001607 148.0
TLS2_k127_803204_0 Bacterial sugar transferase - - - 1.409e-231 730.0
TLS2_k127_803204_1 peptidase dimerisation domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 599.0
TLS2_k127_803204_10 PFAM Xylose isomerase domain-containing protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002436 271.0
TLS2_k127_803204_13 Sortase family K07284 - 3.4.22.70 0.0000000000000000000000000000000000000000000007567 176.0
TLS2_k127_803204_15 sh3 domain protein - - - 0.00000000000000000000000000001602 131.0
TLS2_k127_803204_16 alpha-L-arabinofuranosidase - - - 0.000000000000000001047 96.0
TLS2_k127_803204_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 513.0
TLS2_k127_803204_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 480.0
TLS2_k127_803204_4 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 417.0
TLS2_k127_803204_5 Protein of unknown function (DUF4012) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 428.0
TLS2_k127_803204_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 388.0
TLS2_k127_803204_7 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 329.0
TLS2_k127_803204_8 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009245 296.0
TLS2_k127_803204_9 Polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 290.0
TLS2_k127_82634_0 B12 binding domain - - - 6.933e-253 784.0
TLS2_k127_82634_1 Predicted membrane protein (DUF2079) - - - 2.318e-250 801.0
TLS2_k127_82634_10 Sugar kinase of the NBD HSP70 family, may containing an N-terminal HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 319.0
TLS2_k127_82634_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002279 256.0
TLS2_k127_82634_12 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003181 245.0
TLS2_k127_82634_13 Putative bacterial sensory transduction regulator - - - 0.00000000000000000000000000000000000000000000000002595 184.0
TLS2_k127_82634_14 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000002696 183.0
TLS2_k127_82634_15 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000000000000000000002621 162.0
TLS2_k127_82634_16 Domain of unknown function (DUF1905) - - - 0.0000000000000000000000000000000000000001284 152.0
TLS2_k127_82634_17 Translation initiation factor SUI1 K03113 - - 0.00000000000000000000000000000225 123.0
TLS2_k127_82634_18 Protein of unknown function (DUF433) - - - 0.00000000000000000000000000000911 126.0
TLS2_k127_82634_19 PFAM glycosyl transferase family 39 - - - 0.000000000000007514 87.0
TLS2_k127_82634_2 - - - - 6.363e-222 699.0
TLS2_k127_82634_20 SMART helix-turn-helix domain protein K15539 - - 0.00000000001396 73.0
TLS2_k127_82634_21 Involved in the tonB-independent uptake of proteins K13669 - - 0.00000002013 63.0
TLS2_k127_82634_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 1.879e-219 685.0
TLS2_k127_82634_4 PFAM transferase hexapeptide repeat containing protein K00975 - 2.7.7.27 5.072e-200 630.0
TLS2_k127_82634_5 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003346 548.0
TLS2_k127_82634_6 Domain of unknown function (DUF4432) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003961 520.0
TLS2_k127_82634_7 Restriction endonuclease K07448 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 368.0
TLS2_k127_82634_8 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 367.0
TLS2_k127_82634_9 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 316.0
TLS2_k127_833494_0 PFAM 4Fe-4S K00184,K21308 - - 0.0 1116.0
TLS2_k127_833494_1 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009054 355.0
TLS2_k127_850037_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 327.0
TLS2_k127_850037_1 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000002655 214.0
TLS2_k127_850037_3 pathogenesis K12287 - - 0.0000000000002648 84.0
TLS2_k127_850037_4 TIGRFAM outer membrane adhesin like proteiin - - - 0.00000002849 68.0
TLS2_k127_850860_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1363.0
TLS2_k127_850860_1 Cation transport regulator K06197 - - 0.0000000000000000000000000003104 116.0
TLS2_k127_850860_2 Nitrate reductase delta subunit - - - 0.000000000000000000000005474 116.0
TLS2_k127_850860_3 Biotin-lipoyl like K01993 - - 0.0000003094 57.0
TLS2_k127_863825_0 PFAM glycosyl transferase, family 51 - - - 0.0 1200.0
TLS2_k127_863825_2 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 439.0
TLS2_k127_863825_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 339.0
TLS2_k127_863825_4 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000152 282.0
TLS2_k127_863825_5 - - - - 0.00000000000000000000000001937 112.0
TLS2_k127_871161_0 ABC transporter, ATP-binding protein - - - 7.154e-265 823.0
TLS2_k127_871161_1 PFAM NAD-dependent epimerase dehydratase K12454 - 5.1.3.10 1.592e-257 812.0
TLS2_k127_871161_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 530.0
TLS2_k127_871161_3 NmrA-like family K17947 - 5.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 527.0
TLS2_k127_871161_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 501.0
TLS2_k127_871161_5 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 418.0
TLS2_k127_871161_6 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 408.0
TLS2_k127_871161_7 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009891 291.0
TLS2_k127_912232_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0 1948.0
TLS2_k127_912232_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 400.0
TLS2_k127_912232_2 SNARE associated Golgi protein - - - 0.00000000000000000000000005519 115.0
TLS2_k127_924546_0 FAD linked oxidases, C-terminal domain - - - 4.131e-242 770.0
TLS2_k127_924546_1 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 355.0
TLS2_k127_924546_2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000001976 254.0
TLS2_k127_943805_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 495.0
TLS2_k127_943805_1 ADP-glyceromanno-heptose 6-epimerase activity K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000001409 184.0
TLS2_k127_943805_2 response regulator - - - 0.000000000000009821 74.0
TLS2_k127_943805_3 Belongs to the 'phage' integrase family K03733 - - 0.0000000001827 63.0
TLS2_k127_943805_4 Plasmid pRiA4b ORF-3-like protein - - - 0.000000001503 59.0
TLS2_k127_947356_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 5.389e-307 962.0
TLS2_k127_947356_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 5.747e-218 682.0
TLS2_k127_947356_10 Nucleotidyl transferase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 396.0
TLS2_k127_947356_11 glycerate dehydrogenase activity K00049,K13403 GO:0000166,GO:0003008,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006081,GO:0006082,GO:0006807,GO:0007588,GO:0008150,GO:0008152,GO:0008465,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0019752,GO:0022607,GO:0030267,GO:0031406,GO:0031907,GO:0031974,GO:0032501,GO:0032787,GO:0034641,GO:0036094,GO:0042579,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046487,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051287,GO:0055114,GO:0065003,GO:0070013,GO:0070402,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363 1.1.1.79,1.1.1.81,1.5.1.15,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009987 383.0
TLS2_k127_947356_12 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 366.0
TLS2_k127_947356_13 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 390.0
TLS2_k127_947356_14 PFAM DegV family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 334.0
TLS2_k127_947356_15 PFAM RNA binding S1 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 314.0
TLS2_k127_947356_16 PFAM Haloacid dehalogenase domain protein hydrolase K01101,K02566 - 3.1.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 294.0
TLS2_k127_947356_17 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006701 278.0
TLS2_k127_947356_18 PFAM short-chain dehydrogenase reductase SDR K00059,K03793 - 1.1.1.100,1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000001151 267.0
TLS2_k127_947356_19 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000007619 179.0
TLS2_k127_947356_2 PFAM phosphoesterase, RecJ domain protein K07462 - - 1.082e-208 662.0
TLS2_k127_947356_20 PFAM response regulator receiver - - - 0.000000000000000000000000007014 115.0
TLS2_k127_947356_21 KaiB domain protein K08481 - - 0.0000000000000001033 83.0
TLS2_k127_947356_22 lyase activity - - - 0.000000000000001199 89.0
TLS2_k127_947356_24 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000002206 71.0
TLS2_k127_947356_25 - - - - 0.00000007472 65.0
TLS2_k127_947356_26 sequence-specific DNA binding - - - 0.0000005557 63.0
TLS2_k127_947356_27 Circadian clock protein kaic K08482 - - 0.00005571 47.0
TLS2_k127_947356_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 9.201e-195 619.0
TLS2_k127_947356_4 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 5.477e-194 617.0
TLS2_k127_947356_5 PFAM metal-dependent phosphohydrolase, HD sub domain K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 573.0
TLS2_k127_947356_6 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006409 558.0
TLS2_k127_947356_7 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 559.0
TLS2_k127_947356_8 Protein kinase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 548.0
TLS2_k127_947356_9 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 454.0
TLS2_k127_953604_0 cellulose binding K13735,K20276,K21449 - - 0.00000000000000000000000000009655 136.0
TLS2_k127_953604_1 PFAM aldo keto reductase - - - 0.000000000000000000000001104 114.0
TLS2_k127_953604_2 PFAM Polymorphic membrane protein, Chlamydia - - - 0.000000000000005368 91.0
TLS2_k127_953604_3 Amidohydrolase K07046 - - 0.000001218 60.0
TLS2_k127_953604_4 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000489 46.0
TLS2_k127_971387_0 LysM domain K12204 - - 1.567e-234 760.0
TLS2_k127_971387_1 Amidohydrolase family - - - 1.715e-215 677.0
TLS2_k127_971387_2 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 511.0
TLS2_k127_971387_3 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009047 463.0
TLS2_k127_971387_4 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009024 383.0
TLS2_k127_971387_5 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 289.0
TLS2_k127_971387_6 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001019 282.0
TLS2_k127_971387_7 - - - - 0.00000000000000000000000000000000000000001416 162.0
TLS2_k127_979138_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 409.0
TLS2_k127_979138_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 378.0
TLS2_k127_979138_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000002928 91.0
TLS2_k127_979138_11 PFAM Tetratricopeptide - - - 0.00000000000002331 87.0
TLS2_k127_979138_12 Belongs to the UPF0337 (CsbD) family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000131 66.0
TLS2_k127_979138_2 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000005283 244.0
TLS2_k127_979138_3 response regulator K07669 - - 0.0000000000000000000000000000000000000000000000000000000001876 209.0
TLS2_k127_979138_4 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000002121 179.0
TLS2_k127_979138_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000002707 189.0
TLS2_k127_979138_6 helix_turn_helix, Lux Regulon K07694,K11618 - - 0.00000000000000000000000000000832 129.0
TLS2_k127_979138_7 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000002329 126.0
TLS2_k127_979138_8 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000002862 117.0
TLS2_k127_979138_9 Histidine kinase - - - 0.000000000000000000001462 112.0
TLS2_k127_988938_0 Xylose isomerase-like TIM barrel K03335 - 4.2.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 432.0
TLS2_k127_988938_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 333.0
TLS2_k127_988938_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000229 138.0
TLS2_k127_988938_3 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000002149 90.0