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Overview

ID MAG04030
Name TLS2_bin.72
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order GCA-2731375
Family GCA-2731375
Genus JAVKFY01
Species
Assembly information
Completeness (%) 93.35
Contamination (%) 0.64
GC content (%) 72.0
N50 (bp) 24,385
Genome size (bp) 4,568,639

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4310

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1030772_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1541.0
TLS2_k127_1030772_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 434.0
TLS2_k127_1030772_10 peptidyl-tyrosine sulfation - - - 0.0000000000006515 73.0
TLS2_k127_1030772_11 - - - - 0.000002933 58.0
TLS2_k127_1030772_2 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005702 278.0
TLS2_k127_1030772_3 COG1076 DnaJ-domain-containing proteins 1 K05801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005114 262.0
TLS2_k127_1030772_4 Short-chain dehydrogenase reductase (SDR) - - - 0.0000000000000000000000000000000000000000000000000000000000000000006779 235.0
TLS2_k127_1030772_5 decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000000332 185.0
TLS2_k127_1030772_6 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000008329 176.0
TLS2_k127_1030772_7 Sodium Bile acid symporter family - - - 0.00000000000000000000000000000000000000000000001916 183.0
TLS2_k127_1030772_8 surface antigen - - - 0.000000000000000000000000000000000000000000000082 177.0
TLS2_k127_1030772_9 ubiE/COQ5 methyltransferase family - - - 0.000000000000007538 76.0
TLS2_k127_1041118_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 561.0
TLS2_k127_1041118_1 EAL domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002548 256.0
TLS2_k127_1047647_0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 514.0
TLS2_k127_1047647_1 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 504.0
TLS2_k127_1047647_10 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000006112 116.0
TLS2_k127_1047647_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000008629 81.0
TLS2_k127_1047647_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 433.0
TLS2_k127_1047647_3 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 443.0
TLS2_k127_1047647_4 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000004503 283.0
TLS2_k127_1047647_5 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004432 270.0
TLS2_k127_1047647_6 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000428 219.0
TLS2_k127_1047647_7 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000009719 194.0
TLS2_k127_1047647_8 DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000002768 187.0
TLS2_k127_1047647_9 Auxin binding protein - - - 0.000000000000000000000000000000000000297 145.0
TLS2_k127_1052903_0 MlrC C-terminus - - - 1.042e-212 675.0
TLS2_k127_1052903_1 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 554.0
TLS2_k127_1052903_10 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000006651 268.0
TLS2_k127_1052903_11 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000005294 213.0
TLS2_k127_1052903_12 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K00797,K01611 - 2.5.1.16,4.1.1.50 0.000000000000000000000000000000000000000000000001313 179.0
TLS2_k127_1052903_13 of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000008531 159.0
TLS2_k127_1052903_14 Glutathione S-transferase - - - 0.00000000000000000000000000001472 126.0
TLS2_k127_1052903_15 Protein of unknown function (DUF2794) - - - 0.0000000000007413 77.0
TLS2_k127_1052903_2 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 437.0
TLS2_k127_1052903_3 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 431.0
TLS2_k127_1052903_4 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 388.0
TLS2_k127_1052903_5 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 364.0
TLS2_k127_1052903_6 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 338.0
TLS2_k127_1052903_7 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 312.0
TLS2_k127_1052903_8 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 318.0
TLS2_k127_1052903_9 ATP dependent DNA ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007002 276.0
TLS2_k127_1088986_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 1.312e-197 636.0
TLS2_k127_1088986_1 Molydopterin dinucleotide binding domain K07306,K07309,K07310,K08352 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0033797,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.8.5.3,1.8.5.5,1.97.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 567.0
TLS2_k127_1088986_2 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 389.0
TLS2_k127_1088986_3 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 319.0
TLS2_k127_1088986_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008574 289.0
TLS2_k127_1088986_5 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000008589 132.0
TLS2_k127_1088986_6 MatE - - - 0.000000000000000002654 89.0
TLS2_k127_1108671_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 8.561e-208 674.0
TLS2_k127_1108671_1 PFAM Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 597.0
TLS2_k127_1108671_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 552.0
TLS2_k127_1108671_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 492.0
TLS2_k127_1108671_4 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01928,K01929,K15792 - 6.3.2.10,6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 469.0
TLS2_k127_1108671_5 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009833 454.0
TLS2_k127_1108671_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 425.0
TLS2_k127_1108671_7 Belongs to the D-alanine--D-alanine ligase family K00075,K01921 - 1.3.1.98,6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009751 399.0
TLS2_k127_1108671_8 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007544 368.0
TLS2_k127_1108671_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 345.0
TLS2_k127_11296_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 4.739e-298 934.0
TLS2_k127_11296_1 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.807e-250 784.0
TLS2_k127_11296_10 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 401.0
TLS2_k127_11296_11 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 407.0
TLS2_k127_11296_12 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 348.0
TLS2_k127_11296_13 Transcriptional - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 324.0
TLS2_k127_11296_14 mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 327.0
TLS2_k127_11296_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009568 317.0
TLS2_k127_11296_16 N-formylglutamate amidohydrolase K01458,K01479 - 3.5.1.68,3.5.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 304.0
TLS2_k127_11296_17 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008093 306.0
TLS2_k127_11296_18 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 289.0
TLS2_k127_11296_19 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006143 252.0
TLS2_k127_11296_2 Di- and tricarboxylate transporters - - - 4.789e-240 758.0
TLS2_k127_11296_20 Fatty acid desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008583 247.0
TLS2_k127_11296_21 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008645 256.0
TLS2_k127_11296_22 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000003019 234.0
TLS2_k127_11296_23 Acyl-CoA dehydrogenase, C-terminal domain K16047,K20942 - 1.14.14.12,1.14.14.27 0.00000000000000000000000000000000000000000000000000000000008307 231.0
TLS2_k127_11296_24 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000001903 203.0
TLS2_k127_11296_25 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000000001695 177.0
TLS2_k127_11296_26 Belongs to the HesB IscA family K15724 - - 0.00000000000000000000000000000000000000005607 154.0
TLS2_k127_11296_27 Phosphoglycerate mutase - - - 0.0000000000000000000000000000000000000001702 170.0
TLS2_k127_11296_28 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000002075 150.0
TLS2_k127_11296_29 PAS domain - - - 0.00000000000000000000003129 111.0
TLS2_k127_11296_3 FAD dependent oxidoreductase - - - 1.687e-205 664.0
TLS2_k127_11296_30 Thioesterase superfamily - - - 0.00000000000007724 79.0
TLS2_k127_11296_31 Sporulation related domain - - - 0.00000000004718 70.0
TLS2_k127_11296_32 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.0000000007545 60.0
TLS2_k127_11296_4 Belongs to the thiolase family K00626 - 2.3.1.9 4.671e-196 621.0
TLS2_k127_11296_5 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 551.0
TLS2_k127_11296_6 deoxyguanosinetriphosphate triphosphohydrolase-like protein K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 519.0
TLS2_k127_11296_7 Amidohydrolase family K05603 - 3.5.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 481.0
TLS2_k127_11296_8 imidazolonepropionase activity K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 473.0
TLS2_k127_11296_9 Nitronate monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006172 411.0
TLS2_k127_1184602_0 DNA polymerase III alpha subunit K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1339.0
TLS2_k127_1184602_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 4.319e-270 850.0
TLS2_k127_1184602_10 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 382.0
TLS2_k127_1184602_11 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 378.0
TLS2_k127_1184602_12 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 376.0
TLS2_k127_1184602_13 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 355.0
TLS2_k127_1184602_14 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 341.0
TLS2_k127_1184602_15 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 336.0
TLS2_k127_1184602_16 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 319.0
TLS2_k127_1184602_17 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 286.0
TLS2_k127_1184602_18 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001467 263.0
TLS2_k127_1184602_19 protein conserved in bacteria K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004814 249.0
TLS2_k127_1184602_2 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 3.472e-261 825.0
TLS2_k127_1184602_20 COG4591 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.000000000000000000000000000000000000000000000000000000000003798 211.0
TLS2_k127_1184602_21 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000003008 209.0
TLS2_k127_1184602_22 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000004283 192.0
TLS2_k127_1184602_23 COG2825 Outer membrane protein - - - 0.0000000000000000000000000000006134 134.0
TLS2_k127_1184602_24 OmpA family - - - 0.0000000003688 72.0
TLS2_k127_1184602_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.212e-225 707.0
TLS2_k127_1184602_4 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 9.173e-205 651.0
TLS2_k127_1184602_5 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 580.0
TLS2_k127_1184602_6 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 536.0
TLS2_k127_1184602_7 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 540.0
TLS2_k127_1184602_8 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 498.0
TLS2_k127_1184602_9 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007427 394.0
TLS2_k127_1189288_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 4.552e-240 760.0
TLS2_k127_1189288_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007536 566.0
TLS2_k127_1189288_10 DinB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 307.0
TLS2_k127_1189288_11 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001638 262.0
TLS2_k127_1189288_12 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000002453 250.0
TLS2_k127_1189288_13 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000299 226.0
TLS2_k127_1189288_14 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000002519 214.0
TLS2_k127_1189288_15 Histidine kinase K20971 - - 0.0000000000000000000000000000000000006817 158.0
TLS2_k127_1189288_16 response regulator, receiver - - - 0.0000000000000000000000001098 112.0
TLS2_k127_1189288_2 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 437.0
TLS2_k127_1189288_3 COG1960 Acyl-CoA dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009548 402.0
TLS2_k127_1189288_4 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 374.0
TLS2_k127_1189288_5 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 351.0
TLS2_k127_1189288_6 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000918 354.0
TLS2_k127_1189288_7 Pfam:Kce - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 344.0
TLS2_k127_1189288_8 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 330.0
TLS2_k127_1189288_9 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 334.0
TLS2_k127_1189440_0 COG1042 Acyl-CoA synthetase (NDP forming) K09181 - - 9.449e-292 920.0
TLS2_k127_1189440_1 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 9.048e-219 686.0
TLS2_k127_1189440_10 - - - - 0.00000000000000009011 94.0
TLS2_k127_1189440_11 - - - - 0.000611 46.0
TLS2_k127_1189440_2 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 2.565e-211 659.0
TLS2_k127_1189440_3 transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 434.0
TLS2_k127_1189440_4 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 401.0
TLS2_k127_1189440_5 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003523 288.0
TLS2_k127_1189440_6 SnoaL-like polyketide cyclase K07255 - - 0.0000000000000000000000000000000000000000000000000000003409 199.0
TLS2_k127_1189440_7 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000015 98.0
TLS2_k127_1189440_8 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000007461 102.0
TLS2_k127_1189440_9 Dodecin K09165 - - 0.00000000000000000164 98.0
TLS2_k127_1193733_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 2.126e-242 756.0
TLS2_k127_1193733_1 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 365.0
TLS2_k127_1193733_2 Outer membrane efflux protein K12543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 354.0
TLS2_k127_1193733_3 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000567 318.0
TLS2_k127_1193733_4 alpha/beta hydrolase fold K01066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006858 294.0
TLS2_k127_1193733_5 FecR protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003568 294.0
TLS2_k127_1193733_6 RES - - - 0.00000000000000000000000000000001119 146.0
TLS2_k127_1194014_0 COG1960 Acyl-CoA dehydrogenases K14448 - 1.3.8.12 1.626e-222 702.0
TLS2_k127_1194014_1 AMP-binding enzyme C-terminal domain - - - 1.013e-212 672.0
TLS2_k127_1194014_10 Polycystin cation channel K08714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 354.0
TLS2_k127_1194014_11 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 311.0
TLS2_k127_1194014_12 PFAM luciferase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 307.0
TLS2_k127_1194014_13 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 296.0
TLS2_k127_1194014_14 LysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005362 275.0
TLS2_k127_1194014_15 tRNA (Guanine-1)-methyltransferase K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000064 247.0
TLS2_k127_1194014_16 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0000000000000000000000000000000000000000000000000000000000000009257 224.0
TLS2_k127_1194014_17 COG0694 Thioredoxin-like proteins and domains - - - 0.000000000000000000000000000000000000000000000000000000000008514 220.0
TLS2_k127_1194014_18 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000006494 188.0
TLS2_k127_1194014_19 Competence-damaged protein - - - 0.00000000000000000000000000000000000000000000000006586 189.0
TLS2_k127_1194014_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007248 610.0
TLS2_k127_1194014_20 FecR protein - - - 0.00000000000000000000000000000000000000000000003216 197.0
TLS2_k127_1194014_21 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000002595 190.0
TLS2_k127_1194014_22 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000002621 168.0
TLS2_k127_1194014_23 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000004116 157.0
TLS2_k127_1194014_24 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000006177 154.0
TLS2_k127_1194014_25 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000000000001547 151.0
TLS2_k127_1194014_26 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000001142 126.0
TLS2_k127_1194014_27 FecR protein - - - 0.0000000000000000000005418 114.0
TLS2_k127_1194014_28 ThiS family K03636 - - 0.000000000000000000728 99.0
TLS2_k127_1194014_29 Thioesterase-like superfamily K01075 - 3.1.2.23 0.0000000001318 75.0
TLS2_k127_1194014_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 599.0
TLS2_k127_1194014_30 - - - - 0.0008719 53.0
TLS2_k127_1194014_4 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 591.0
TLS2_k127_1194014_5 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 514.0
TLS2_k127_1194014_6 Uncharacterized protein family UPF0004 K18707 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009342 499.0
TLS2_k127_1194014_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005304 402.0
TLS2_k127_1194014_8 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 377.0
TLS2_k127_1194014_9 Transmembrane sensor domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 392.0
TLS2_k127_1225561_0 thiolester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 299.0
TLS2_k127_1225561_1 Shikimate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001093 286.0
TLS2_k127_1225561_10 - - - - 0.0003983 51.0
TLS2_k127_1225561_2 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003266 285.0
TLS2_k127_1225561_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000005629 226.0
TLS2_k127_1225561_4 - - - - 0.00000000000000000000000000004848 125.0
TLS2_k127_1225561_5 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000004278 89.0
TLS2_k127_1225561_6 Transcriptional regulator PadR-like family - - - 0.00000000000000002958 89.0
TLS2_k127_1225561_7 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000001312 86.0
TLS2_k127_1225561_8 Evidence 5 No homology to any previously reported sequences - - - 0.00000008585 54.0
TLS2_k127_1225561_9 nuclear chromosome segregation - - - 0.0000007993 63.0
TLS2_k127_1241417_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.745e-277 860.0
TLS2_k127_1241417_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.981e-257 804.0
TLS2_k127_1241417_10 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 484.0
TLS2_k127_1241417_11 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 482.0
TLS2_k127_1241417_12 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 469.0
TLS2_k127_1241417_13 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 454.0
TLS2_k127_1241417_14 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008123 449.0
TLS2_k127_1241417_15 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 427.0
TLS2_k127_1241417_16 His Kinase A (phosphoacceptor) domain K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 403.0
TLS2_k127_1241417_17 peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 403.0
TLS2_k127_1241417_18 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 364.0
TLS2_k127_1241417_19 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 342.0
TLS2_k127_1241417_2 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 8.95e-227 726.0
TLS2_k127_1241417_20 Amino-transferase class IV K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 357.0
TLS2_k127_1241417_21 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 326.0
TLS2_k127_1241417_22 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 308.0
TLS2_k127_1241417_23 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 302.0
TLS2_k127_1241417_24 DNA polymerase III subunit delta K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 306.0
TLS2_k127_1241417_25 protein conserved in bacteria K09798 - - 0.0000000000000000000000000000000000000000000000000000000000000000004851 237.0
TLS2_k127_1241417_26 COG2867 Oligoketide cyclase lipid transport protein K18588 - - 0.000000000000000000000000000000000000000000000000000000000000472 215.0
TLS2_k127_1241417_27 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000003671 229.0
TLS2_k127_1241417_28 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000695 192.0
TLS2_k127_1241417_29 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000116 162.0
TLS2_k127_1241417_3 Sigma-54 interaction domain K07712 - - 9.75e-226 729.0
TLS2_k127_1241417_30 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000000000000000000003895 173.0
TLS2_k127_1241417_31 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000002814 144.0
TLS2_k127_1241417_32 Preprotein translocase subunit SecG K03075 - - 0.00000000000000000000003328 103.0
TLS2_k127_1241417_33 Septum formation initiator - - - 0.00000000000000000005439 93.0
TLS2_k127_1241417_34 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000001423 75.0
TLS2_k127_1241417_4 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 2.634e-225 728.0
TLS2_k127_1241417_5 Potassium transporter peripheral membrane component K03499 - - 2.347e-203 642.0
TLS2_k127_1241417_6 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.186e-195 631.0
TLS2_k127_1241417_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 7.605e-195 636.0
TLS2_k127_1241417_8 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 614.0
TLS2_k127_1241417_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 509.0
TLS2_k127_1245597_0 Domain of unknown function (DUF4915) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 519.0
TLS2_k127_1245597_1 Sigma-54 interaction domain K03974 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 400.0
TLS2_k127_1245597_2 Phage shock protein K03969 - - 0.000000000000000000000000000000000000000000000000000001727 218.0
TLS2_k127_1245597_3 Protein of unknown function (DUF1045) - - - 0.000000000000000000000000000000000000000000000000000426 194.0
TLS2_k127_1245597_4 Phage shock protein B K03970 - - 0.00000000000000000000000949 102.0
TLS2_k127_1245597_5 PspC domain - - - 0.000000000000000000002472 109.0
TLS2_k127_1245597_6 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000000000003155 96.0
TLS2_k127_1245597_7 TIGRFAM phosphonate metabolism protein PhnM K06162 - 3.6.1.63 0.0000000000000004715 78.0
TLS2_k127_1283398_0 Heparinase II/III-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 457.0
TLS2_k127_1283398_1 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 377.0
TLS2_k127_1283398_2 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 319.0
TLS2_k127_1283398_3 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 319.0
TLS2_k127_1283398_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004478 280.0
TLS2_k127_1283398_5 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000000000003765 222.0
TLS2_k127_1283398_6 regulation of ruffle assembly - - - 0.00000000000000000000000000000000000000000000000000000000000005039 231.0
TLS2_k127_1283398_7 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000002348 135.0
TLS2_k127_1283398_8 Ankyrin repeats (many copies) - - - 0.000000000000000006221 91.0
TLS2_k127_1285227_0 GMC oxidoreductase K00108 - 1.1.99.1 4.413e-281 872.0
TLS2_k127_1285227_1 Transporter associated domain K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 619.0
TLS2_k127_1285227_10 phosphorelay signal transduction system - - - 0.00000000000000000007308 96.0
TLS2_k127_1285227_12 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.000001753 57.0
TLS2_k127_1285227_13 Evidence 5 No homology to any previously reported sequences - - - 0.000005437 53.0
TLS2_k127_1285227_15 Evidence 5 No homology to any previously reported sequences - - - 0.0004293 46.0
TLS2_k127_1285227_2 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 474.0
TLS2_k127_1285227_3 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009934 291.0
TLS2_k127_1285227_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 282.0
TLS2_k127_1285227_5 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001016 282.0
TLS2_k127_1285227_6 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000002766 215.0
TLS2_k127_1285227_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000000000000008677 192.0
TLS2_k127_1285227_8 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000886 192.0
TLS2_k127_1285227_9 PFAM thioesterase superfamily - - - 0.00000000000000000000000001607 115.0
TLS2_k127_12913_0 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 6.555e-245 768.0
TLS2_k127_12913_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 7.516e-199 631.0
TLS2_k127_12913_10 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000000000000000000001076 241.0
TLS2_k127_12913_11 Cupin domain - - - 0.000000000000000000000000000000000000000000000001523 192.0
TLS2_k127_12913_12 - - - - 0.0000000000000000000000000000000000000000008145 166.0
TLS2_k127_12913_13 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000002769 167.0
TLS2_k127_12913_14 Esterase-like activity of phytase - - - 0.00000000000000000000000000000000000000006044 161.0
TLS2_k127_12913_15 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000001768 141.0
TLS2_k127_12913_16 Thioesterase-like superfamily - - - 0.0000000000000000000000002152 114.0
TLS2_k127_12913_17 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.000786 45.0
TLS2_k127_12913_2 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 523.0
TLS2_k127_12913_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 454.0
TLS2_k127_12913_4 Required for the activity of the bacterial periplasmic transport system of putrescine K11073 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0019808,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 448.0
TLS2_k127_12913_5 oxidoreductase FAD NAD(P)-binding domain protein K14581 - 1.18.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 402.0
TLS2_k127_12913_6 PFAM binding-protein-dependent transport systems inner membrane component K11071,K11075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 393.0
TLS2_k127_12913_7 COG1177 ABC-type spermidine putrescine transport system, permease component II K11074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 357.0
TLS2_k127_12913_8 COG0708 Exonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 333.0
TLS2_k127_12913_9 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16165 - 3.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 329.0
TLS2_k127_1304957_0 FAD linked oxidases, C-terminal domain K18930 - - 0.0 1295.0
TLS2_k127_1304957_1 Phosphate acyltransferases - - - 4.445e-261 834.0
TLS2_k127_1304957_10 sensor diguanylate cyclase phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 447.0
TLS2_k127_1304957_11 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 418.0
TLS2_k127_1304957_12 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 430.0
TLS2_k127_1304957_13 Phosphoenolpyruvate phosphomutase K20454 - 4.1.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 399.0
TLS2_k127_1304957_14 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009247 360.0
TLS2_k127_1304957_15 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 362.0
TLS2_k127_1304957_16 branched-chain amino acid K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 350.0
TLS2_k127_1304957_17 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 347.0
TLS2_k127_1304957_18 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 324.0
TLS2_k127_1304957_19 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 344.0
TLS2_k127_1304957_2 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 573.0
TLS2_k127_1304957_20 Domain of unknown function DUF108 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 304.0
TLS2_k127_1304957_21 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 301.0
TLS2_k127_1304957_22 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008726 308.0
TLS2_k127_1304957_23 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 299.0
TLS2_k127_1304957_24 Domain of unknown function (DUF427) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001278 283.0
TLS2_k127_1304957_25 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008633 277.0
TLS2_k127_1304957_26 HpcH/HpaI aldolase/citrate lyase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007517 248.0
TLS2_k127_1304957_27 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000006081 243.0
TLS2_k127_1304957_28 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000008102 234.0
TLS2_k127_1304957_29 - - - - 0.0000000000000000000000000000000000000000000000000000000000000008222 229.0
TLS2_k127_1304957_3 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 562.0
TLS2_k127_1304957_30 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000001459 229.0
TLS2_k127_1304957_31 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000000000000001046 226.0
TLS2_k127_1304957_32 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000007811 228.0
TLS2_k127_1304957_33 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000005918 190.0
TLS2_k127_1304957_34 Putative tRNA binding domain K06878 - - 0.000000000000000000000000000000000000000002401 171.0
TLS2_k127_1304957_35 transcriptional regulator - - - 0.0000000000000000000000000000000000000000244 162.0
TLS2_k127_1304957_36 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000002635 150.0
TLS2_k127_1304957_37 Putative peptidoglycan binding domain - - - 0.000000000000000000000000001326 121.0
TLS2_k127_1304957_38 - - - - 0.0000000000000000000000989 103.0
TLS2_k127_1304957_39 - - - - 0.000000000000000006272 92.0
TLS2_k127_1304957_4 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 555.0
TLS2_k127_1304957_40 - - - - 0.00000000000000364 82.0
TLS2_k127_1304957_41 protein conserved in bacteria K09806 - - 0.00000000000002536 76.0
TLS2_k127_1304957_42 Protein of unknown function (DUF1003) - - - 0.0000000000009915 75.0
TLS2_k127_1304957_43 PAS domain - - - 0.0000002296 60.0
TLS2_k127_1304957_44 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0005052 53.0
TLS2_k127_1304957_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 541.0
TLS2_k127_1304957_6 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 486.0
TLS2_k127_1304957_7 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 474.0
TLS2_k127_1304957_8 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 426.0
TLS2_k127_1304957_9 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 436.0
TLS2_k127_1323412_0 malic enzyme K00029 - 1.1.1.40 9.791e-292 914.0
TLS2_k127_1323412_1 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 5.833e-281 869.0
TLS2_k127_1323412_10 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 294.0
TLS2_k127_1323412_11 Enoyl-CoA hydratase K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000001736 269.0
TLS2_k127_1323412_12 PIN domain - - - 0.000000000000000000000000000000000000000000000000000001387 197.0
TLS2_k127_1323412_13 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.00000000000000000000000000000000000000000000000000009962 196.0
TLS2_k127_1323412_14 protein involved in outer membrane biogenesis K07289,K07290 - - 0.0000000000000000000000000004001 130.0
TLS2_k127_1323412_15 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000000000000003875 109.0
TLS2_k127_1323412_16 NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000002607 101.0
TLS2_k127_1323412_17 Type III flagellar switch regulator (C-ring) FliN C-term K02417 - - 0.00000000000000002244 85.0
TLS2_k127_1323412_18 - - - - 0.000000000000001604 87.0
TLS2_k127_1323412_19 - - - - 0.000000000001181 74.0
TLS2_k127_1323412_2 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 2.772e-265 825.0
TLS2_k127_1323412_21 dehydrogenase K00253 - 1.3.8.4 0.000003571 52.0
TLS2_k127_1323412_3 Biotin carboxylase C-terminal domain K01965,K01968,K13777 - 6.4.1.3,6.4.1.4,6.4.1.5 1.537e-262 825.0
TLS2_k127_1323412_4 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 9.447e-262 826.0
TLS2_k127_1323412_5 Bacterial protein of unknown function (DUF853) K06915 - - 2.797e-199 638.0
TLS2_k127_1323412_6 amidohydrolase - - - 5.118e-197 624.0
TLS2_k127_1323412_7 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003747 439.0
TLS2_k127_1323412_8 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 395.0
TLS2_k127_1323412_9 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 346.0
TLS2_k127_1329041_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1316.0
TLS2_k127_1329041_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 1e-224 710.0
TLS2_k127_1329041_10 RNA pseudouridylate synthase K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 316.0
TLS2_k127_1329041_11 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K01487,K11991 - 3.5.4.1,3.5.4.3,3.5.4.33 0.000000000000000000000000000000000000000000000000000000001704 211.0
TLS2_k127_1329041_12 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000009865 194.0
TLS2_k127_1329041_13 Protein of unknown function (DUF3035) - - - 0.000000000000000000000000000000000000000000000000002806 192.0
TLS2_k127_1329041_14 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000009895 198.0
TLS2_k127_1329041_15 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000001891 175.0
TLS2_k127_1329041_16 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000007182 171.0
TLS2_k127_1329041_17 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.000000000000000000000000000000000000000000002275 175.0
TLS2_k127_1329041_18 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000003238 128.0
TLS2_k127_1329041_19 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000003619 119.0
TLS2_k127_1329041_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 4.475e-200 636.0
TLS2_k127_1329041_20 Glycosyl transferases group 1 - - - 0.000000000006108 77.0
TLS2_k127_1329041_21 Glycosyltransferase like family 2 - - - 0.0000005002 62.0
TLS2_k127_1329041_3 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 567.0
TLS2_k127_1329041_4 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008458 488.0
TLS2_k127_1329041_5 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 494.0
TLS2_k127_1329041_6 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003811 445.0
TLS2_k127_1329041_7 Protein containing von Willebrand factor type A (VWA) domain K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 415.0
TLS2_k127_1329041_8 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 395.0
TLS2_k127_1329041_9 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 337.0
TLS2_k127_1345849_0 PFAM Gamma-glutamyltranspeptidase - - - 5.643e-218 688.0
TLS2_k127_1345849_1 Bacterial sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 390.0
TLS2_k127_1345849_2 Bacterial regulatory helix-turn-helix protein, lysR family K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 360.0
TLS2_k127_1345849_3 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000006005 143.0
TLS2_k127_1346421_0 COG1960 Acyl-CoA dehydrogenases K20035 - - 9.767e-222 713.0
TLS2_k127_1346421_1 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 1.362e-196 624.0
TLS2_k127_1346421_10 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000001977 87.0
TLS2_k127_1346421_2 Tripartite tricarboxylate transporter TctA family - - - 7.043e-194 623.0
TLS2_k127_1346421_3 Mandelate Racemase Muconate Lactonizing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 505.0
TLS2_k127_1346421_4 secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004445 439.0
TLS2_k127_1346421_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008134 379.0
TLS2_k127_1346421_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006115 336.0
TLS2_k127_1346421_7 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 337.0
TLS2_k127_1346421_8 Tripartite tricarboxylate transporter TctB family - - - 0.000000000000000000000000185 114.0
TLS2_k127_1346421_9 dehydratase - - - 0.00000000000000000000003747 110.0
TLS2_k127_1361205_0 AMP-binding enzyme C-terminal domain - - - 4.252e-200 635.0
TLS2_k127_1361205_1 COG0642 Signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006465 473.0
TLS2_k127_1361205_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 434.0
TLS2_k127_1361205_3 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 398.0
TLS2_k127_1361205_4 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 290.0
TLS2_k127_1361205_5 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009814 280.0
TLS2_k127_1361205_6 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000001279 190.0
TLS2_k127_1361205_7 FecR protein - - - 0.000000000000000000000000000007352 128.0
TLS2_k127_1361205_8 ABC-type transport auxiliary lipoprotein component - - - 0.000000000000002362 91.0
TLS2_k127_1364516_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.867e-274 859.0
TLS2_k127_1364516_1 Involved in the TonB-independent uptake of proteins K03641 - - 2.584e-211 664.0
TLS2_k127_1364516_10 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 338.0
TLS2_k127_1364516_11 ABC-type multidrug transport system, ATPase and permease K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 329.0
TLS2_k127_1364516_12 COG0811 Biopolymer transport proteins K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 328.0
TLS2_k127_1364516_13 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004573 320.0
TLS2_k127_1364516_14 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 306.0
TLS2_k127_1364516_15 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009827 266.0
TLS2_k127_1364516_16 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.0000000000000000000000000000000000000000000000000000001483 196.0
TLS2_k127_1364516_17 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000000000000000001256 198.0
TLS2_k127_1364516_18 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000512 203.0
TLS2_k127_1364516_19 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000003823 192.0
TLS2_k127_1364516_2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 544.0
TLS2_k127_1364516_20 Large family of predicted nucleotide-binding domains K18828 - - 0.000000000000000000000000000000000000000000000009791 174.0
TLS2_k127_1364516_21 Biopolymer transport protein K03559,K03560 - - 0.00000000000000000000000000000000000000001316 163.0
TLS2_k127_1364516_22 Cell division and transport-associated protein TolA K03646 - - 0.0000000000000000000000000000000000000000573 163.0
TLS2_k127_1364516_23 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000000105 156.0
TLS2_k127_1364516_24 endoribonuclease L-PSP - - - 0.000000000000000000000000000000000001337 145.0
TLS2_k127_1364516_25 thioesterase' K07107 - - 0.0000000000000000000000000000000000808 138.0
TLS2_k127_1364516_26 Cupin domain - - - 0.00000000000000000000000000000001001 140.0
TLS2_k127_1364516_27 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.000000000000000000000000000000819 123.0
TLS2_k127_1364516_28 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000000000000001042 120.0
TLS2_k127_1364516_29 COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.0000000000000000009741 99.0
TLS2_k127_1364516_3 Phosphoglycerate kinase K00927 GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 538.0
TLS2_k127_1364516_30 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000502 88.0
TLS2_k127_1364516_31 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000001437 89.0
TLS2_k127_1364516_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003924 499.0
TLS2_k127_1364516_5 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 475.0
TLS2_k127_1364516_6 MotA TolQ ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 439.0
TLS2_k127_1364516_7 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009817 411.0
TLS2_k127_1364516_8 flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 400.0
TLS2_k127_1364516_9 YmdB-like protein K09769 GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 355.0
TLS2_k127_1366519_0 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 460.0
TLS2_k127_1366519_1 Aspartate tyrosine aromatic aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009452 441.0
TLS2_k127_1366519_2 Steryl acetyl hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 319.0
TLS2_k127_1373979_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1311.0
TLS2_k127_1373979_1 Amylo-alpha-1,6-glucosidase - - - 5.714e-280 902.0
TLS2_k127_1373979_10 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006425 520.0
TLS2_k127_1373979_11 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007862 493.0
TLS2_k127_1373979_12 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 511.0
TLS2_k127_1373979_13 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 488.0
TLS2_k127_1373979_14 glycyl-tRNA synthetase, alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 483.0
TLS2_k127_1373979_15 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 452.0
TLS2_k127_1373979_16 ATPase with chaperone activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 408.0
TLS2_k127_1373979_17 Zinc-binding dehydrogenase K00001,K19745 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 400.0
TLS2_k127_1373979_18 Serine dehydrogenase proteinase K04773,K04774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 323.0
TLS2_k127_1373979_19 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008634 273.0
TLS2_k127_1373979_2 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 2.388e-237 753.0
TLS2_k127_1373979_20 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000004851 240.0
TLS2_k127_1373979_21 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000002028 236.0
TLS2_k127_1373979_22 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000001202 211.0
TLS2_k127_1373979_23 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000003217 147.0
TLS2_k127_1373979_3 AMP-binding enzyme K12508 - 6.2.1.34 2.325e-223 708.0
TLS2_k127_1373979_4 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00520,K21739 - 1.16.1.1 4.602e-213 677.0
TLS2_k127_1373979_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 8.114e-208 672.0
TLS2_k127_1373979_6 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 612.0
TLS2_k127_1373979_7 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 593.0
TLS2_k127_1373979_8 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007235 574.0
TLS2_k127_1373979_9 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 545.0
TLS2_k127_1374054_0 COG0480 Translation elongation factors (GTPases) K02355 - - 1.361e-242 767.0
TLS2_k127_1374054_1 Carboxyl transferase domain - - - 7.475e-224 717.0
TLS2_k127_1374054_10 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009594 457.0
TLS2_k127_1374054_11 secretion protein HlyD K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 312.0
TLS2_k127_1374054_12 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 295.0
TLS2_k127_1374054_13 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003946 281.0
TLS2_k127_1374054_14 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001547 265.0
TLS2_k127_1374054_15 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.00000000000000000000000000000000000000000000000000000000000000008406 236.0
TLS2_k127_1374054_16 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000001711 201.0
TLS2_k127_1374054_17 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.00000000000000000000000000000000000000009386 161.0
TLS2_k127_1374054_18 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000006784 138.0
TLS2_k127_1374054_19 Transcriptional regulator, MarR K06075 - - 0.0000000000000000000000001703 123.0
TLS2_k127_1374054_2 Aminotransferase class I and II K00812 - 2.6.1.1 1.981e-205 644.0
TLS2_k127_1374054_20 Uncharacterized protein family UPF0016 - - - 0.00000000000000007705 84.0
TLS2_k127_1374054_21 Common central domain of tyrosinase K00505 - 1.14.18.1 0.000001077 61.0
TLS2_k127_1374054_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 584.0
TLS2_k127_1374054_4 Gamma-glutamyltranspeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 569.0
TLS2_k127_1374054_5 Pfam SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 557.0
TLS2_k127_1374054_6 Putative sugar-binding N-terminal domain K21948 - 2.7.1.217 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 504.0
TLS2_k127_1374054_7 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 496.0
TLS2_k127_1374054_8 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 490.0
TLS2_k127_1374054_9 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 482.0
TLS2_k127_1385526_0 Luciferase-like monooxygenase K04091,K20938 - 1.14.14.28,1.14.14.5 4.973e-198 627.0
TLS2_k127_1385526_1 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 443.0
TLS2_k127_1385526_10 COG3335 Transposase and inactivated derivatives - - - 0.0000000007819 62.0
TLS2_k127_1385526_11 peroxiredoxin activity K03386,K03564 - 1.11.1.15 0.000000002268 61.0
TLS2_k127_1385526_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008647 355.0
TLS2_k127_1385526_3 COG3335 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000001627 228.0
TLS2_k127_1385526_4 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000001961 194.0
TLS2_k127_1385526_5 peroxiredoxin activity K03564 - 1.11.1.15 0.00000000000000000000000000000000001227 137.0
TLS2_k127_1385526_6 Transposase - - - 0.0000000000000005123 80.0
TLS2_k127_1385526_7 Acetyltransferase (GNAT) domain - - - 0.00000000000002126 81.0
TLS2_k127_1385526_8 COG3335 Transposase and inactivated derivatives - - - 0.000000000001437 67.0
TLS2_k127_1385526_9 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.00000000007034 70.0
TLS2_k127_1413942_0 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 2.528e-226 716.0
TLS2_k127_1413942_1 Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009049 426.0
TLS2_k127_1413942_2 mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 438.0
TLS2_k127_1413942_3 polyphosphate kinase 2 K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 322.0
TLS2_k127_1413942_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000001694 225.0
TLS2_k127_1413942_5 Rhomboid family - - - 0.000000000000000000000000000003663 137.0
TLS2_k127_1413942_6 transduction histidine kinase - - - 0.00000000000000000000000001533 113.0
TLS2_k127_1440642_0 Hydantoinase/oxoprolinase - - - 2.87e-278 874.0
TLS2_k127_1440642_1 Hydantoinase B/oxoprolinase - - - 3.627e-262 819.0
TLS2_k127_1440642_2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 616.0
TLS2_k127_1440642_3 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 452.0
TLS2_k127_1440642_4 AMP-binding protein K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 430.0
TLS2_k127_1440642_5 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K09461 - 1.14.13.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 440.0
TLS2_k127_1440642_6 PFAM short-chain dehydrogenase reductase SDR K00034,K00059 - 1.1.1.100,1.1.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001085 269.0
TLS2_k127_1440642_7 Hemerythrin - - - 0.000000000000000000000000000000000000000000000005169 178.0
TLS2_k127_1440642_8 PFAM PRC-barrel domain protein - - - 0.0000000000000002374 86.0
TLS2_k127_1512268_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 9.261e-215 676.0
TLS2_k127_1512268_1 hydrolase of the metallo-beta-lactamase superfamily K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 618.0
TLS2_k127_1512268_2 COG4591 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 341.0
TLS2_k127_1512268_3 methylmalonyl-CoA epimerase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000001815 231.0
TLS2_k127_1512268_4 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000001105 84.0
TLS2_k127_1512268_5 Protein of unknown function (DUF1467) - - - 0.0000000000000001508 81.0
TLS2_k127_1512268_6 - - - - 0.0000000000006159 76.0
TLS2_k127_1522068_0 Heat shock 70 kDa protein K04043 - - 1.886e-318 984.0
TLS2_k127_1522068_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 609.0
TLS2_k127_1522068_10 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000019 247.0
TLS2_k127_1522068_11 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000001219 207.0
TLS2_k127_1522068_12 GrpE K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000001224 175.0
TLS2_k127_1522068_13 protein conserved in bacteria K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000003036 173.0
TLS2_k127_1522068_14 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000005486 130.0
TLS2_k127_1522068_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 548.0
TLS2_k127_1522068_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 532.0
TLS2_k127_1522068_4 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 458.0
TLS2_k127_1522068_5 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 419.0
TLS2_k127_1522068_6 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 362.0
TLS2_k127_1522068_7 Acetyltransferase (GNAT) domain K22310 - 2.3.2.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 296.0
TLS2_k127_1522068_8 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 293.0
TLS2_k127_1522068_9 RecR protein K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 282.0
TLS2_k127_1606242_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K16877 - 1.3.99.8 0.0 1277.0
TLS2_k127_1606242_1 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 9.698e-246 782.0
TLS2_k127_1606242_10 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.000000000000000000000000000000000000000000000000000000006667 201.0
TLS2_k127_1606242_11 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000002552 161.0
TLS2_k127_1606242_12 Protein of unknown function (DUF2796) - - - 0.00000000000000000000000000000000000000009642 157.0
TLS2_k127_1606242_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000001578 144.0
TLS2_k127_1606242_14 Protein of unknown function (DUF3299) K09950 - - 0.0000000000000000000000000000001862 142.0
TLS2_k127_1606242_15 PRC-barrel domain - - - 0.000000000000000000000000009571 122.0
TLS2_k127_1606242_16 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.000001058 59.0
TLS2_k127_1606242_2 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182,K16874 - 4.1.1.98 3.16e-218 685.0
TLS2_k127_1606242_3 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 564.0
TLS2_k127_1606242_4 Psort location Cytoplasmic, score 7.50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 539.0
TLS2_k127_1606242_5 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 430.0
TLS2_k127_1606242_6 aldo-keto reductase (NADP) activity K05275 - 1.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008659 324.0
TLS2_k127_1606242_7 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000032 278.0
TLS2_k127_1606242_8 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001294 255.0
TLS2_k127_161795_0 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 1.092e-243 760.0
TLS2_k127_161795_1 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 6.711e-195 617.0
TLS2_k127_161795_2 Taurine catabolism dioxygenase TauD, TfdA family K03119,K22303 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 410.0
TLS2_k127_161795_3 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000005632 237.0
TLS2_k127_161795_4 BON domain - - - 0.00000000000000000000000000000000000000000000000000000000000000005859 231.0
TLS2_k127_161795_5 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.00000000000000000000000000000000000000001606 164.0
TLS2_k127_161795_6 Asp/Glu/Hydantoin racemase - - - 0.000000000000000000000000000000000000002107 154.0
TLS2_k127_1674705_0 transport system, fused permease components - - - 0.0 1109.0
TLS2_k127_1674705_1 Enoyl-CoA hydratase/isomerase - - - 5.499e-259 808.0
TLS2_k127_1674705_10 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005366 256.0
TLS2_k127_1674705_11 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001342 255.0
TLS2_k127_1674705_12 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000005914 237.0
TLS2_k127_1674705_13 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002555 258.0
TLS2_k127_1674705_14 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.0000000000000000000000000000000000000000000000000000000000001661 226.0
TLS2_k127_1674705_15 MlaD protein K02067,K06192 - - 0.0000000000000000000000000000000000000000000000000000000000007274 222.0
TLS2_k127_1674705_16 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000000000000000000000000000000000004247 192.0
TLS2_k127_1674705_17 Bacterial protein of unknown function (DUF924) - - - 0.00000000000000000000000000000000000000000000000008167 192.0
TLS2_k127_1674705_18 Sugar-transfer associated ATP-grasp - - - 0.0000000000000000000000000000000000000000000005454 182.0
TLS2_k127_1674705_19 transport system auxiliary component K18480 - - 0.000000000000000000000000000000000000000000003511 181.0
TLS2_k127_1674705_2 benzoyl-CoA oxygenase - - - 1.357e-236 763.0
TLS2_k127_1674705_20 nuclear chromosome segregation - - - 0.000000000000000000000000000973 132.0
TLS2_k127_1674705_21 SnoaL-like domain - - - 0.00000000000000001815 95.0
TLS2_k127_1674705_3 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 6.436e-222 696.0
TLS2_k127_1674705_4 transport system periplasmic component K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 503.0
TLS2_k127_1674705_5 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 426.0
TLS2_k127_1674705_6 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 416.0
TLS2_k127_1674705_7 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 375.0
TLS2_k127_1674705_8 ATPases associated with a variety of cellular activities K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008251 377.0
TLS2_k127_1674705_9 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001074 288.0
TLS2_k127_1696821_0 AMP-dependent synthetase and ligase - - - 0.0 1056.0
TLS2_k127_1696821_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007812 516.0
TLS2_k127_1696821_10 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.000000000000000000000000000000000000003521 154.0
TLS2_k127_1696821_11 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000001144 144.0
TLS2_k127_1696821_12 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000009154 124.0
TLS2_k127_1696821_13 Thioredoxin domain - - - 0.00000000000000000000000006967 109.0
TLS2_k127_1696821_14 mercuric transport protein K08363 - - 0.000000000000000000889 87.0
TLS2_k127_1696821_15 Protein of unknown function (FYDLN_acid) - - - 0.000000000000000005018 89.0
TLS2_k127_1696821_16 - - - - 0.00000000000002166 86.0
TLS2_k127_1696821_17 Predicted membrane protein (DUF2231) - - - 0.000000000000854 81.0
TLS2_k127_1696821_18 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000001262 74.0
TLS2_k127_1696821_2 Benzoate membrane transport protein K05782 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 430.0
TLS2_k127_1696821_20 Belongs to the WrbA family K03809 - 1.6.5.2 0.00004346 52.0
TLS2_k127_1696821_3 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 395.0
TLS2_k127_1696821_4 PFAM Prenyltransferase squalene oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 381.0
TLS2_k127_1696821_5 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 366.0
TLS2_k127_1696821_6 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000869 280.0
TLS2_k127_1696821_7 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000006812 175.0
TLS2_k127_1696821_8 - - - - 0.000000000000000000000000000000000000000000007368 165.0
TLS2_k127_1696821_9 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.000000000000000000000000000000000000000007346 165.0
TLS2_k127_1726210_0 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 1.983e-195 633.0
TLS2_k127_1726210_1 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 299.0
TLS2_k127_1726210_2 MarR family transcriptional regulator - - - 0.00000000000000002545 90.0
TLS2_k127_1726210_3 PFAM Hypoxia induced protein conserved region - - - 0.00007244 48.0
TLS2_k127_1814151_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 9.071e-196 623.0
TLS2_k127_1814151_1 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007406 484.0
TLS2_k127_1814151_2 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 487.0
TLS2_k127_1814151_3 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 403.0
TLS2_k127_1814151_4 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 338.0
TLS2_k127_1814151_5 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 320.0
TLS2_k127_1814151_6 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003872 283.0
TLS2_k127_1814151_7 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000005799 235.0
TLS2_k127_1814151_8 HupE / UreJ protein K03192 - - 0.000000000000000000000000000000000000000000000001745 188.0
TLS2_k127_1814151_9 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000006151 130.0
TLS2_k127_1873893_0 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007833 611.0
TLS2_k127_1873893_1 Type II/IV secretion system protein K02283,K20527 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 326.0
TLS2_k127_1873893_2 Type II secretion system (T2SS), protein F K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003338 277.0
TLS2_k127_1873893_3 Type II secretion system (T2SS), protein F K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005274 261.0
TLS2_k127_1873893_4 Belongs to the Fur family K09823 - - 0.00000000000000000000000000000000000000000000000287 177.0
TLS2_k127_1873893_5 diguanylate cyclase - - - 0.000000000000000000000000000000000000007143 156.0
TLS2_k127_1873893_6 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000002479 155.0
TLS2_k127_1873893_7 Pilus formation protein N terminal region K02280 - - 0.0001718 51.0
TLS2_k127_1878116_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 322.0
TLS2_k127_1878116_1 COG2207 AraC-type DNA-binding domain-containing proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005263 250.0
TLS2_k127_1878116_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000002541 102.0
TLS2_k127_1878116_3 Helix-turn-helix domain - - - 0.0008169 49.0
TLS2_k127_1887629_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.229e-298 928.0
TLS2_k127_1887629_1 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 550.0
TLS2_k127_1887629_2 III protein, CoA-transferase family K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 509.0
TLS2_k127_1887629_3 transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 432.0
TLS2_k127_1887629_4 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002922 250.0
TLS2_k127_1887629_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000000002921 213.0
TLS2_k127_1887629_6 ATP-independent chaperone mediated protein folding - - - 0.000000000000000000000000000000000000000000000000004391 186.0
TLS2_k127_1887629_7 Thioesterase superfamily K10806 - - 0.0000000000000000000000000000000000000007679 151.0
TLS2_k127_1887629_8 dihydrofolate reductase K00287 - 1.5.1.3 0.00000000000000007971 87.0
TLS2_k127_1892415_0 PFAM Type II secretion system protein E K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 533.0
TLS2_k127_1892415_1 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004434 444.0
TLS2_k127_1892415_10 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000003215 173.0
TLS2_k127_1892415_11 fimbrial assembly K02461 - - 0.0000000000000000000000000000000000000004169 169.0
TLS2_k127_1892415_12 CHASE2 K01768 - 4.6.1.1 0.000000000000000000000000000000000000001707 160.0
TLS2_k127_1892415_13 PFAM type II secretion system protein G K02456 - - 0.00000000000000000000000000000000000001757 163.0
TLS2_k127_1892415_14 Type II secretion system protein K K02460 - - 0.00000000000000000000000000004989 132.0
TLS2_k127_1892415_15 General secretion pathway protein K02459 - - 0.000000000000000001427 96.0
TLS2_k127_1892415_16 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000001316 87.0
TLS2_k127_1892415_17 protein transport across the cell outer membrane K02246,K02457,K02459,K02672,K08084 - - 0.0000000000000003252 87.0
TLS2_k127_1892415_18 Cytochrome c-type biogenesis protein K02200 - - 0.000000004948 62.0
TLS2_k127_1892415_19 General secretion pathway protein K02458 - - 0.000009288 53.0
TLS2_k127_1892415_2 NADP-dependent oxidoreductase P1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 366.0
TLS2_k127_1892415_20 General secretion pathway protein M K02462 - - 0.0002814 53.0
TLS2_k127_1892415_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 354.0
TLS2_k127_1892415_4 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 365.0
TLS2_k127_1892415_5 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 335.0
TLS2_k127_1892415_6 of the double-stranded beta helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005305 247.0
TLS2_k127_1892415_7 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003628 253.0
TLS2_k127_1892415_8 Type II secretion system K02455 - - 0.000000000000000000000000000000000000000000000000000000000002561 237.0
TLS2_k127_1892415_9 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000003241 192.0
TLS2_k127_189298_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1551.0
TLS2_k127_189298_1 Required for chromosome condensation and partitioning K03529 - - 1.542e-287 930.0
TLS2_k127_189298_10 May be involved in the biosynthesis of molybdopterin K03638 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 2.7.7.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 284.0
TLS2_k127_189298_11 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000008475 262.0
TLS2_k127_189298_12 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000007358 219.0
TLS2_k127_189298_13 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000005455 214.0
TLS2_k127_189298_14 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000002733 207.0
TLS2_k127_189298_15 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000001621 215.0
TLS2_k127_189298_16 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000001271 168.0
TLS2_k127_189298_17 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000005604 142.0
TLS2_k127_189298_18 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000000000000006783 125.0
TLS2_k127_189298_19 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000005552 94.0
TLS2_k127_189298_2 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008196 586.0
TLS2_k127_189298_20 Protein of unknown function (DUF721) - - - 0.0000000000000000002564 96.0
TLS2_k127_189298_21 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0000000000000003735 86.0
TLS2_k127_189298_3 DNA methylase K13581 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 540.0
TLS2_k127_189298_4 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 546.0
TLS2_k127_189298_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000846 540.0
TLS2_k127_189298_6 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 462.0
TLS2_k127_189298_7 COG1194 A G-specific DNA glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 422.0
TLS2_k127_189298_8 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 344.0
TLS2_k127_189298_9 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 292.0
TLS2_k127_1902359_0 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 510.0
TLS2_k127_1902359_1 Cys/Met metabolism PLP-dependent enzyme K01760 GO:0000096,GO:0000098,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004121,GO:0006082,GO:0006090,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0046483,GO:0047804,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1990414 4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 484.0
TLS2_k127_1902359_2 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 468.0
TLS2_k127_1902359_3 amino acid ABC transporter K02029,K09971,K10002,K10037 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 467.0
TLS2_k127_1902359_4 COG4597 ABC-type amino acid transport system, permease component K09970 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 454.0
TLS2_k127_1902359_5 COG1126 ABC-type polar amino acid transport system, ATPase component K02028,K09972 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 444.0
TLS2_k127_1902359_6 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 344.0
TLS2_k127_1902359_7 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000007723 190.0
TLS2_k127_1902359_8 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000000000007862 181.0
TLS2_k127_1902359_9 thiolester hydrolase activity - - - 0.00000000000000000001428 98.0
TLS2_k127_1903416_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 1.971e-285 903.0
TLS2_k127_1903416_1 Cell division protein FtsI penicillin-binding protein 2 K05515 - 3.4.16.4 5.674e-232 742.0
TLS2_k127_1903416_10 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 322.0
TLS2_k127_1903416_11 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009756 317.0
TLS2_k127_1903416_12 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 308.0
TLS2_k127_1903416_13 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006685 264.0
TLS2_k127_1903416_14 Acetolactate synthase small K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000009475 253.0
TLS2_k127_1903416_15 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000002626 216.0
TLS2_k127_1903416_16 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K13039 - 4.1.1.79 0.0000000000000000000000000000000000000000001556 173.0
TLS2_k127_1903416_17 shape-determining protein K03571 - - 0.0000000000000000000006491 110.0
TLS2_k127_1903416_18 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.0000000001919 64.0
TLS2_k127_1903416_19 Acetyltransferase (GNAT) domain - - - 0.00000000178 66.0
TLS2_k127_1903416_2 Rod shape-determining protein MreB K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008529 593.0
TLS2_k127_1903416_20 cheY-homologous receiver domain - - - 0.000000002187 64.0
TLS2_k127_1903416_21 Addiction module toxin, RelE StbE family - - - 0.0006191 46.0
TLS2_k127_1903416_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 550.0
TLS2_k127_1903416_4 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000621 547.0
TLS2_k127_1903416_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 484.0
TLS2_k127_1903416_6 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 496.0
TLS2_k127_1903416_7 beta-lactamase K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 457.0
TLS2_k127_1903416_8 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 424.0
TLS2_k127_1903416_9 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 329.0
TLS2_k127_1904892_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0 1583.0
TLS2_k127_1904892_1 ABC transporter transmembrane region K02021 - - 6.578e-265 842.0
TLS2_k127_1904892_10 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 404.0
TLS2_k127_1904892_11 ABC-type sugar transport system, periplasmic component K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 398.0
TLS2_k127_1904892_12 Aldo keto - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 368.0
TLS2_k127_1904892_13 Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate K01003 - 4.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 351.0
TLS2_k127_1904892_14 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 329.0
TLS2_k127_1904892_15 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001249 249.0
TLS2_k127_1904892_16 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000005988 229.0
TLS2_k127_1904892_17 PFAM flavin reductase - - - 0.0000000000000000000000000000000000000000000000000000000009655 220.0
TLS2_k127_1904892_18 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000000000000000000003722 180.0
TLS2_k127_1904892_19 PRC-barrel domain - - - 0.00000000000000000000000000000000000002241 158.0
TLS2_k127_1904892_2 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 9.115e-252 787.0
TLS2_k127_1904892_20 Belongs to the BCCT transporter (TC 2.A.15) family K03451 - - 0.0000000000000000000000000000000333 143.0
TLS2_k127_1904892_21 - - - - 0.0000000000000000000000000000007814 130.0
TLS2_k127_1904892_22 PFAM Bacterial regulatory proteins, luxR family - - - 0.000000000000000000000000002837 126.0
TLS2_k127_1904892_23 - - - - 0.000000000000000000000004912 104.0
TLS2_k127_1904892_24 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000001021 115.0
TLS2_k127_1904892_25 Amidase K01426 - 3.5.1.4 0.00000000000000000000001502 102.0
TLS2_k127_1904892_26 PEP-CTERM motif - - - 0.000000000000000000000124 113.0
TLS2_k127_1904892_27 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000001168 93.0
TLS2_k127_1904892_29 Serine aminopeptidase, S33 - - - 0.00000000003518 73.0
TLS2_k127_1904892_3 Belongs to the BCCT transporter (TC 2.A.15) family K03451 - - 3.009e-231 723.0
TLS2_k127_1904892_31 Putative peptidoglycan binding domain - - - 0.000000003586 64.0
TLS2_k127_1904892_4 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006897 597.0
TLS2_k127_1904892_5 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 494.0
TLS2_k127_1904892_6 translation release factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 451.0
TLS2_k127_1904892_7 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 442.0
TLS2_k127_1904892_8 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 441.0
TLS2_k127_1904892_9 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 428.0
TLS2_k127_1905123_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1585.0
TLS2_k127_1905123_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1199.0
TLS2_k127_1905123_2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214,K02438 - 3.2.1.196,3.2.1.68 0.0 1104.0
TLS2_k127_1905123_3 Domain of unknown function (DUF3416) K16147 - 2.4.99.16 0.0 1065.0
TLS2_k127_1905123_4 synthase K06044 - 5.4.99.15 3.106e-280 920.0
TLS2_k127_1905123_5 Domain of unknown function (DUF3459) K00700,K01236 - 2.4.1.18,3.2.1.141 9.484e-241 762.0
TLS2_k127_1905123_6 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 615.0
TLS2_k127_1905123_7 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008437 514.0
TLS2_k127_1905123_8 Fumarate reductase flavoprotein C-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009309 286.0
TLS2_k127_1911789_0 Aminotransferase K14261 GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 610.0
TLS2_k127_1911789_1 single-stranded-DNA-specific exonuclease recJ K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 586.0
TLS2_k127_1911789_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 521.0
TLS2_k127_1911789_3 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446,K11532 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 449.0
TLS2_k127_1911789_4 OmpA family - - - 0.0000000000000000000000002369 114.0
TLS2_k127_1925167_0 COG0367 Asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 5.013e-246 776.0
TLS2_k127_1925167_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 7.83e-242 752.0
TLS2_k127_1925167_10 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 351.0
TLS2_k127_1925167_11 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 338.0
TLS2_k127_1925167_12 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 323.0
TLS2_k127_1925167_13 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006479 282.0
TLS2_k127_1925167_14 2-hydroxychromene-2-carboxylate isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002883 285.0
TLS2_k127_1925167_15 CobQ/CobB/MinD/ParA nucleotide binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002693 276.0
TLS2_k127_1925167_16 polysaccharide export protein K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009287 265.0
TLS2_k127_1925167_17 MatE K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002021 280.0
TLS2_k127_1925167_18 hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002794 270.0
TLS2_k127_1925167_19 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000181 238.0
TLS2_k127_1925167_2 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 4.188e-241 755.0
TLS2_k127_1925167_20 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003501 234.0
TLS2_k127_1925167_21 COG2893 Phosphotransferase system, mannose fructose-specific component IIA K02793 - 2.7.1.191 0.0000000000000000000000000000000000000000000000000000000003938 218.0
TLS2_k127_1925167_22 - - - - 0.0000000000000000000000000000000000000000000000000000000658 214.0
TLS2_k127_1925167_23 peptide-methionine (R)-S-oxide reductase activity K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000001188 191.0
TLS2_k127_1925167_24 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000005075 174.0
TLS2_k127_1925167_25 - - - - 0.00000000000000000000000000000000000000001397 175.0
TLS2_k127_1925167_26 COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism K06023 - - 0.000000000000000000000000000000000000414 144.0
TLS2_k127_1925167_27 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000004571 153.0
TLS2_k127_1925167_28 Usg protein - - - 0.000000000000000000000000001303 115.0
TLS2_k127_1925167_29 Protein conserved in bacteria - - - 0.000000000000000000000000001599 128.0
TLS2_k127_1925167_3 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 1.382e-228 723.0
TLS2_k127_1925167_30 Phosphotransferase System K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702 - 0.00000000000000000000005518 103.0
TLS2_k127_1925167_31 - - - - 0.0000000001758 66.0
TLS2_k127_1925167_4 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 8.534e-206 661.0
TLS2_k127_1925167_5 PAS PAC domain-containing protein - - - 3.775e-198 639.0
TLS2_k127_1925167_6 Stimulus-sensing domain K14980 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 477.0
TLS2_k127_1925167_7 Domain of unknown function (DUF3473) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 379.0
TLS2_k127_1925167_8 Chain length determinant protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 383.0
TLS2_k127_1925167_9 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 362.0
TLS2_k127_1927213_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 591.0
TLS2_k127_1927213_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 594.0
TLS2_k127_1927213_10 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 323.0
TLS2_k127_1927213_11 COG0845 Membrane-fusion protein K16300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 324.0
TLS2_k127_1927213_12 protein involved in exopolysaccharide biosynthesis K16554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000916 294.0
TLS2_k127_1927213_13 PFAM Hemolysin-type calcium-binding repeat (2 copies) K01406 - 3.4.24.40 0.00000000000000000000000000000000000000000000000000000000000000000000000687 267.0
TLS2_k127_1927213_14 Protein of unknown function (DUF1194) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000485 259.0
TLS2_k127_1927213_15 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000002813 232.0
TLS2_k127_1927213_16 universal stress protein - - - 0.000000000000000000000000000000000000000000000000000000000000000007888 252.0
TLS2_k127_1927213_17 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000003417 229.0
TLS2_k127_1927213_18 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000359 224.0
TLS2_k127_1927213_19 - - - - 0.000000000000000000000000000000000000000000006805 176.0
TLS2_k127_1927213_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008127 533.0
TLS2_k127_1927213_20 thiamine kinase activity - - - 0.000000000000000000000000000000000424 149.0
TLS2_k127_1927213_21 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000007017 106.0
TLS2_k127_1927213_22 2-Nitropropane dioxygenase - - - 0.0000000000000000003703 96.0
TLS2_k127_1927213_23 Putative prokaryotic signal transducing protein - - - 0.0000000000000004667 81.0
TLS2_k127_1927213_24 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000914 92.0
TLS2_k127_1927213_3 COG4618 ABC-type protease lipase transport system, ATPase and permease components K12536 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 530.0
TLS2_k127_1927213_4 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 462.0
TLS2_k127_1927213_5 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 466.0
TLS2_k127_1927213_6 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 438.0
TLS2_k127_1927213_7 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 378.0
TLS2_k127_1927213_8 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 340.0
TLS2_k127_1927213_9 Bacterial sugar transferase K03606,K20997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008927 343.0
TLS2_k127_1973826_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1079.0
TLS2_k127_1973826_1 PFAM carboxyl transferase K13778 - 6.4.1.5 1.951e-237 744.0
TLS2_k127_1973826_10 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 383.0
TLS2_k127_1973826_11 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 380.0
TLS2_k127_1973826_12 Pyridoxal-phosphate dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 371.0
TLS2_k127_1973826_13 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 330.0
TLS2_k127_1973826_14 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 304.0
TLS2_k127_1973826_15 Sterol carrier protein - - - 0.000000000000000000000000000004248 122.0
TLS2_k127_1973826_16 Histidine kinase - - - 0.000000000000001014 81.0
TLS2_k127_1973826_17 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000005904 82.0
TLS2_k127_1973826_2 AMP-binding enzyme C-terminal domain - - - 2.839e-208 663.0
TLS2_k127_1973826_3 COG0744 Membrane carboxypeptidase (penicillin-binding protein) K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004974 607.0
TLS2_k127_1973826_4 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 584.0
TLS2_k127_1973826_5 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009176 495.0
TLS2_k127_1973826_6 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008923 454.0
TLS2_k127_1973826_7 Cysteine synthase K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008118 426.0
TLS2_k127_1973826_8 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 410.0
TLS2_k127_1973826_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K13774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 382.0
TLS2_k127_1991508_0 PQQ-like domain K00114,K20937 - 1.1.2.8,1.1.5.11 1.369e-230 735.0
TLS2_k127_1991508_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 468.0
TLS2_k127_1991508_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 471.0
TLS2_k127_1991508_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 332.0
TLS2_k127_1991508_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 342.0
TLS2_k127_1991508_5 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009082 284.0
TLS2_k127_1991508_6 Bacterial extracellular solute-binding proteins, family 3 - - - 0.00000000000000000000000000000000000000000000000000000000000002926 229.0
TLS2_k127_1991508_7 Protein of unknown function (DUF1194) - - - 0.000000000000000000000000000000000000000006759 167.0
TLS2_k127_1991508_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000001184 112.0
TLS2_k127_1991508_9 Protein of unknown function (DUF2937) - - - 0.0000000000000000000017 100.0
TLS2_k127_1991878_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.479e-264 825.0
TLS2_k127_1991878_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.542e-230 747.0
TLS2_k127_1991878_10 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000758 507.0
TLS2_k127_1991878_11 PQQ-like domain K17713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 498.0
TLS2_k127_1991878_12 malonyl CoA-acyl carrier protein transacylase K00645,K15327 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 425.0
TLS2_k127_1991878_13 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009283 389.0
TLS2_k127_1991878_14 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004463 376.0
TLS2_k127_1991878_15 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 389.0
TLS2_k127_1991878_16 Predicted permease YjgP/YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007083 369.0
TLS2_k127_1991878_17 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 360.0
TLS2_k127_1991878_18 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 353.0
TLS2_k127_1991878_19 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 355.0
TLS2_k127_1991878_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 8.081e-224 703.0
TLS2_k127_1991878_20 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 360.0
TLS2_k127_1991878_21 16S rRNA methyltransferase RsmB/F K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 351.0
TLS2_k127_1991878_22 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 353.0
TLS2_k127_1991878_23 cytochrome p450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 353.0
TLS2_k127_1991878_24 short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007883 334.0
TLS2_k127_1991878_25 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 323.0
TLS2_k127_1991878_26 Chaperone SurA K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 314.0
TLS2_k127_1991878_27 Bacterial protein of unknown function (DUF899) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 308.0
TLS2_k127_1991878_28 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009649 299.0
TLS2_k127_1991878_29 Predicted permease YjgP/YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 302.0
TLS2_k127_1991878_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 8.277e-204 640.0
TLS2_k127_1991878_30 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 291.0
TLS2_k127_1991878_31 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001138 278.0
TLS2_k127_1991878_32 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001344 283.0
TLS2_k127_1991878_33 Amino Acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006947 270.0
TLS2_k127_1991878_34 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001273 248.0
TLS2_k127_1991878_35 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000007508 257.0
TLS2_k127_1991878_36 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000008005 212.0
TLS2_k127_1991878_37 Ribosomal protein L9, N-terminal domain K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000009811 201.0
TLS2_k127_1991878_38 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000002699 194.0
TLS2_k127_1991878_39 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000000000000001185 169.0
TLS2_k127_1991878_4 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 604.0
TLS2_k127_1991878_40 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000000000000000000000000769 162.0
TLS2_k127_1991878_41 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000309 138.0
TLS2_k127_1991878_42 membrane protein, required for colicin V production K03558 - - 0.000000000000000000000000000000000176 144.0
TLS2_k127_1991878_43 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000000000002022 130.0
TLS2_k127_1991878_44 Activator of Hsp90 ATPase - - - 0.000000000000000000000002197 108.0
TLS2_k127_1991878_45 Integrase - - - 0.00000000000000000001061 96.0
TLS2_k127_1991878_46 - - - - 0.000000000000003999 82.0
TLS2_k127_1991878_47 SpoVG K06412 - - 0.0000000006939 66.0
TLS2_k127_1991878_48 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000145 64.0
TLS2_k127_1991878_49 Integrase - - - 0.00000003353 60.0
TLS2_k127_1991878_5 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 593.0
TLS2_k127_1991878_51 ABC transporter K06158 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0005003 45.0
TLS2_k127_1991878_6 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 581.0
TLS2_k127_1991878_7 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 568.0
TLS2_k127_1991878_8 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 534.0
TLS2_k127_1991878_9 P-aminobenzoate N-oxygenase AurF - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 510.0
TLS2_k127_1997909_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 2.121e-222 695.0
TLS2_k127_1997909_1 IrrE N-terminal-like domain K07110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 587.0
TLS2_k127_1997909_2 Pyridoxal-phosphate dependent enzyme K01751 - 4.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000001068 265.0
TLS2_k127_1997909_3 Plasmid pRiA4b ORF-3-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000004742 226.0
TLS2_k127_1997909_4 LysE type translocator - - - 0.0000000000000000000000000000000000000000002359 168.0
TLS2_k127_1997909_5 Fic/DOC family K07341 - - 0.0000000000000000000000000000000004259 136.0
TLS2_k127_1997909_6 Transposase and inactivated K07494 - - 0.00000000000001502 73.0
TLS2_k127_1997909_7 - - - - 0.00000000001351 78.0
TLS2_k127_1997909_8 SpoVT / AbrB like domain - - - 0.0000000041 66.0
TLS2_k127_2019290_0 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 - 6.4.1.1 0.0 1730.0
TLS2_k127_2019290_1 transglutaminase domain protein - - - 0.0 1483.0
TLS2_k127_2019290_10 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 606.0
TLS2_k127_2019290_11 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 602.0
TLS2_k127_2019290_12 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 602.0
TLS2_k127_2019290_13 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 578.0
TLS2_k127_2019290_14 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 573.0
TLS2_k127_2019290_15 Bacterial extracellular solute-binding protein K02027,K10236 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007261 554.0
TLS2_k127_2019290_16 N-acyl-D-aspartate D-glutamate deacylase K06015 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 528.0
TLS2_k127_2019290_17 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 497.0
TLS2_k127_2019290_18 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 499.0
TLS2_k127_2019290_19 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 477.0
TLS2_k127_2019290_2 FAD dependent oxidoreductase central domain - - - 0.0 1304.0
TLS2_k127_2019290_20 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 487.0
TLS2_k127_2019290_21 Arsenical pump membrane protein K03893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 460.0
TLS2_k127_2019290_22 Metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009378 452.0
TLS2_k127_2019290_23 Binding-protein-dependent transport system inner membrane component K02025,K10237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 447.0
TLS2_k127_2019290_24 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 435.0
TLS2_k127_2019290_25 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 430.0
TLS2_k127_2019290_26 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 407.0
TLS2_k127_2019290_27 ATPase component of ABC-type sugar transporter K10111 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 404.0
TLS2_k127_2019290_28 transport system permease K02026,K05815,K10238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 400.0
TLS2_k127_2019290_29 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009245 377.0
TLS2_k127_2019290_3 A predicted alpha-helical domain with a conserved ER motif. - - - 1.495e-248 794.0
TLS2_k127_2019290_30 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 390.0
TLS2_k127_2019290_31 Glutaminase K01425 - 3.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 376.0
TLS2_k127_2019290_32 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005786 363.0
TLS2_k127_2019290_33 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 358.0
TLS2_k127_2019290_34 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 375.0
TLS2_k127_2019290_35 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 354.0
TLS2_k127_2019290_36 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009244 319.0
TLS2_k127_2019290_37 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 330.0
TLS2_k127_2019290_38 COG1108 ABC-type Mn2 Zn2 transport systems permease components K09816 GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 310.0
TLS2_k127_2019290_39 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 305.0
TLS2_k127_2019290_4 Alpha-amylase domain K01182,K01187,K05343 - 3.2.1.1,3.2.1.10,3.2.1.20,5.4.99.16 1.041e-234 737.0
TLS2_k127_2019290_40 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004925 306.0
TLS2_k127_2019290_41 COG4531 ABC-type Zn2 transport system, periplasmic component surface adhesin K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 304.0
TLS2_k127_2019290_42 carboxylic ester hydrolase activity K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 299.0
TLS2_k127_2019290_43 Phosphoenolpyruvate phosphomutase K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002369 287.0
TLS2_k127_2019290_44 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001994 277.0
TLS2_k127_2019290_45 hydrolases of the HAD superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005063 274.0
TLS2_k127_2019290_46 Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system K02074,K09817 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001366 261.0
TLS2_k127_2019290_47 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000001589 240.0
TLS2_k127_2019290_48 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000000000000008521 246.0
TLS2_k127_2019290_49 Zinc-dependent metalloprotease - - - 0.0000000000000000000000000000000000000000000000000000000000000894 222.0
TLS2_k127_2019290_5 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 1.249e-230 722.0
TLS2_k127_2019290_50 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000002109 215.0
TLS2_k127_2019290_51 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000001744 222.0
TLS2_k127_2019290_52 Integral membrane protein TerC family - - - 0.00000000000000000000000000000000000000000000000000000004474 202.0
TLS2_k127_2019290_53 Protein of unknown function (DUF1203) - - - 0.0000000000000000000000000000000000000000000000000000162 193.0
TLS2_k127_2019290_54 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000000000000000000000000000000000149 168.0
TLS2_k127_2019290_55 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000002182 142.0
TLS2_k127_2019290_56 cheY-homologous receiver domain - - - 0.0000000000000000000000000000008555 126.0
TLS2_k127_2019290_57 protein conserved in bacteria K09796 - - 0.0000000000000000000000000000106 134.0
TLS2_k127_2019290_58 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000115 118.0
TLS2_k127_2019290_59 Exopolysaccharide synthesis, ExoD - - - 0.000000000000000002851 94.0
TLS2_k127_2019290_6 Glycine cleavage T-protein C-terminal barrel domain - - - 1.238e-228 716.0
TLS2_k127_2019290_60 transport system, periplasmic component - - - 0.00000000000000002693 90.0
TLS2_k127_2019290_61 PRC-barrel domain - - - 0.000000000003952 79.0
TLS2_k127_2019290_62 Sel1-like repeats. - - - 0.0000000001049 75.0
TLS2_k127_2019290_63 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000015 68.0
TLS2_k127_2019290_7 A circularly permuted ATPgrasp - - - 2.294e-217 685.0
TLS2_k127_2019290_8 ribosomal rna small subunit methyltransferase - - - 1.774e-208 658.0
TLS2_k127_2019290_9 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 6.577e-208 656.0
TLS2_k127_2020780_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1095.0
TLS2_k127_2020780_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007636 489.0
TLS2_k127_2020780_2 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 482.0
TLS2_k127_2020780_3 methionine synthase K00544,K00548 - 2.1.1.13,2.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008825 446.0
TLS2_k127_2020780_4 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 370.0
TLS2_k127_2020780_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002265 287.0
TLS2_k127_2020780_6 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000462 265.0
TLS2_k127_2020780_7 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001156 237.0
TLS2_k127_2020780_8 Cytochrome oxidase maturation protein - - - 0.0000000000003394 77.0
TLS2_k127_2020780_9 alginic acid biosynthetic process K03496,K09000 - - 0.00003249 57.0
TLS2_k127_2031533_0 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 595.0
TLS2_k127_2031533_1 KR domain K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000001767 254.0
TLS2_k127_2031533_2 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.00000000000000000000000000000000000000000000000000005371 210.0
TLS2_k127_2031533_3 arsenate reductase K00537 - 1.20.4.1 0.000000000000000000000000000000000000007606 161.0
TLS2_k127_2031533_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000397 138.0
TLS2_k127_2031533_5 Thioesterase superfamily - - - 0.00000000000000000009254 99.0
TLS2_k127_2050300_0 Aconitase family (aconitate hydratase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 594.0
TLS2_k127_2050300_1 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 506.0
TLS2_k127_2050300_10 Phospholipase_D-nuclease N-terminal - - - 0.000000000000003554 86.0
TLS2_k127_2050300_11 Luciferase-like monooxygenase - - - 0.000001007 57.0
TLS2_k127_2050300_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 327.0
TLS2_k127_2050300_3 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 310.0
TLS2_k127_2050300_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000008109 224.0
TLS2_k127_2050300_5 - - - - 0.0000000000000000000000000000000000000000001839 167.0
TLS2_k127_2050300_6 transport system, fused permease components - - - 0.0000000000000000000000000000000000000000002986 162.0
TLS2_k127_2050300_7 Peptidase family M23 - - - 0.00000000000000000000000000000000000001068 152.0
TLS2_k127_2050300_8 - - - - 0.000000000000000000000000000000000188 147.0
TLS2_k127_2050300_9 5-carboxymethyl-2-hydroxymuconate isomerase K01826 - 5.3.3.10 0.00000000000000000000000000000008477 128.0
TLS2_k127_2052977_0 PFAM extracellular solute-binding protein family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 604.0
TLS2_k127_2052977_1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 594.0
TLS2_k127_2052977_2 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 585.0
TLS2_k127_2052977_3 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007174 471.0
TLS2_k127_2052977_4 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 395.0
TLS2_k127_2052977_5 Protein of unknown function (DUF3750) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005031 283.0
TLS2_k127_2052977_6 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000331 257.0
TLS2_k127_2052977_7 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000168 216.0
TLS2_k127_2052977_8 Sugar-transfer associated ATP-grasp - - - 0.000000000000000000000000000000000000000000005113 179.0
TLS2_k127_2052977_9 MarR family transcriptional regulator - - - 0.000000000000000000000000000000001637 149.0
TLS2_k127_2054650_0 Formate dehydrogenase subunit alpha - - - 0.0 1388.0
TLS2_k127_2054650_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 0.0 1084.0
TLS2_k127_2054650_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 0.0 1041.0
TLS2_k127_2054650_3 Dehydrogenase K00122 - 1.17.1.9 1.429e-194 613.0
TLS2_k127_2054650_4 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 441.0
TLS2_k127_2054650_5 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 359.0
TLS2_k127_2054650_6 2Fe-2S -binding K03518,K07302 - 1.2.5.3,1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000002594 279.0
TLS2_k127_2054650_7 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000005134 261.0
TLS2_k127_2054650_8 symbiont process K00612 - - 0.00000000000000000000000000003009 117.0
TLS2_k127_2054650_9 ThiS family K03636 - - 0.000000000004048 69.0
TLS2_k127_2066267_0 Protein of unknown function (DUF2817) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006255 265.0
TLS2_k127_2066267_1 addiction module antidote protein HigA - - - 0.000000000000000000000000000000000002349 140.0
TLS2_k127_2066267_2 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000000000000000002907 145.0
TLS2_k127_2066267_3 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.00000000000000000000000002671 109.0
TLS2_k127_2066267_4 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.0000000000000000000000009827 119.0
TLS2_k127_2066267_5 Zinc carboxypeptidase - - - 0.000000000000000000000001421 104.0
TLS2_k127_2066267_6 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000001603 93.0
TLS2_k127_2066267_7 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.00000000000135 75.0
TLS2_k127_2066267_8 Plasmid maintenance system killer protein K07334 - - 0.000001686 51.0
TLS2_k127_2168761_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K18361 - 1.17.5.1,3.1.2.25 0.0 1179.0
TLS2_k127_2168761_1 Cytochrome c - - - 3.818e-263 833.0
TLS2_k127_2168761_10 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 349.0
TLS2_k127_2168761_11 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 316.0
TLS2_k127_2168761_12 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003122 273.0
TLS2_k127_2168761_13 4Fe-4S binding domain K18362 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001291 287.0
TLS2_k127_2168761_14 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001461 273.0
TLS2_k127_2168761_15 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000001866 253.0
TLS2_k127_2168761_16 short-chain dehydrogenase reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004479 240.0
TLS2_k127_2168761_17 Thioesterase - - - 0.00000000000000000000000000000000000000129 153.0
TLS2_k127_2168761_18 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.0000000000000000000000000000000001061 140.0
TLS2_k127_2168761_19 cheY-homologous receiver domain - - - 0.00000000000000000000000000000005086 138.0
TLS2_k127_2168761_2 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 2.908e-231 734.0
TLS2_k127_2168761_20 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000003708 125.0
TLS2_k127_2168761_21 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000000000000001094 119.0
TLS2_k127_2168761_22 DMSO reductase anchor subunit (DmsC) K18363 - - 0.00000000000000000000000000003138 136.0
TLS2_k127_2168761_23 Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000000002478 106.0
TLS2_k127_2168761_24 Cupin 2, conserved barrel domain protein - - - 0.0000000002007 70.0
TLS2_k127_2168761_3 PFAM amidohydrolase K07045 - - 1.316e-210 659.0
TLS2_k127_2168761_4 Phosphofructokinase K00850,K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 541.0
TLS2_k127_2168761_5 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007293 550.0
TLS2_k127_2168761_6 asparagine synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 436.0
TLS2_k127_2168761_7 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 402.0
TLS2_k127_2168761_8 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 413.0
TLS2_k127_2168761_9 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 340.0
TLS2_k127_2169884_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1151.0
TLS2_k127_2169884_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.0 1104.0
TLS2_k127_2169884_10 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 328.0
TLS2_k127_2169884_11 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 319.0
TLS2_k127_2169884_12 F420-0 Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 301.0
TLS2_k127_2169884_13 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 301.0
TLS2_k127_2169884_14 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000399 252.0
TLS2_k127_2169884_15 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001452 235.0
TLS2_k127_2169884_16 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000001431 235.0
TLS2_k127_2169884_17 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000001238 249.0
TLS2_k127_2169884_18 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000000003077 214.0
TLS2_k127_2169884_19 COG1587 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000006891 211.0
TLS2_k127_2169884_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 449.0
TLS2_k127_2169884_20 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000003364 185.0
TLS2_k127_2169884_21 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000005553 197.0
TLS2_k127_2169884_22 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000149 183.0
TLS2_k127_2169884_23 Guanylyl transferase CofC like K14941 - 2.7.7.68 0.00000000000000000000000000001167 135.0
TLS2_k127_2169884_24 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000005558 92.0
TLS2_k127_2169884_25 COG3263 NhaP-type Na H and K H antiporters with a unique C-terminal domain K11105 - - 0.000000006923 60.0
TLS2_k127_2169884_3 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 428.0
TLS2_k127_2169884_4 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 389.0
TLS2_k127_2169884_5 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 374.0
TLS2_k127_2169884_6 LPPG Fo 2-phospho-L-lactate transferase K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 360.0
TLS2_k127_2169884_7 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 339.0
TLS2_k127_2169884_8 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009951 334.0
TLS2_k127_2169884_9 HemY protein N-terminus K02498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 339.0
TLS2_k127_2228947_0 Belongs to the ClpA ClpB family K03694 - - 0.0 1143.0
TLS2_k127_2228947_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.163e-203 642.0
TLS2_k127_2228947_10 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 497.0
TLS2_k127_2228947_11 Belongs to the peptidase S1C family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 502.0
TLS2_k127_2228947_12 NAD NADP octopine nopaline dehydrogenase K04940 - 1.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 476.0
TLS2_k127_2228947_13 Inosine-uridine preferring nucleoside hydrolase K01239 GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.2.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 469.0
TLS2_k127_2228947_14 Iron-containing alcohol dehydrogenase K00043 - 1.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 466.0
TLS2_k127_2228947_15 Iron-containing alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007946 461.0
TLS2_k127_2228947_16 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 475.0
TLS2_k127_2228947_17 UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 449.0
TLS2_k127_2228947_18 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005962 429.0
TLS2_k127_2228947_19 PFAM Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009845 426.0
TLS2_k127_2228947_2 Major Facilitator Superfamily - - - 4.166e-199 628.0
TLS2_k127_2228947_20 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 419.0
TLS2_k127_2228947_21 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 424.0
TLS2_k127_2228947_22 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 410.0
TLS2_k127_2228947_23 protein conserved in bacteria K09927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 417.0
TLS2_k127_2228947_24 E COG0620 Methionine synthase II (cobalamin-independent) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 408.0
TLS2_k127_2228947_25 Protein of unknown function (DUF3179) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 398.0
TLS2_k127_2228947_26 COG0471 Di- and tricarboxylate transporters - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008153 399.0
TLS2_k127_2228947_27 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 381.0
TLS2_k127_2228947_28 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 381.0
TLS2_k127_2228947_29 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 363.0
TLS2_k127_2228947_3 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 616.0
TLS2_k127_2228947_30 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 376.0
TLS2_k127_2228947_31 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 341.0
TLS2_k127_2228947_32 D-alanyl-D-alanine carboxypeptidase K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 338.0
TLS2_k127_2228947_33 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 325.0
TLS2_k127_2228947_34 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 347.0
TLS2_k127_2228947_35 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 322.0
TLS2_k127_2228947_36 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005018 312.0
TLS2_k127_2228947_37 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 319.0
TLS2_k127_2228947_38 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009445 310.0
TLS2_k127_2228947_39 Protein of unknown function (DUF2817) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 301.0
TLS2_k127_2228947_4 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 601.0
TLS2_k127_2228947_40 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 294.0
TLS2_k127_2228947_41 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001166 269.0
TLS2_k127_2228947_42 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001545 265.0
TLS2_k127_2228947_43 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008045 251.0
TLS2_k127_2228947_44 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000024 245.0
TLS2_k127_2228947_45 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000003008 261.0
TLS2_k127_2228947_46 Choline/ethanolamine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001018 263.0
TLS2_k127_2228947_47 Belongs to the peptidase S8 family K08651,K14645 - 3.4.21.66 0.0000000000000000000000000000000000000000000000000000000000000000007626 241.0
TLS2_k127_2228947_48 translation initiation inhibitor, yjgF family - - - 0.000000000000000000000000000000000000000000000000000000000000002682 220.0
TLS2_k127_2228947_49 Transition state regulatory protein AbrB K07120 - - 0.00000000000000000000000000000000000000000000000000000000000001433 229.0
TLS2_k127_2228947_5 phosphomannomutase K01840 - 5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 602.0
TLS2_k127_2228947_50 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000005591 219.0
TLS2_k127_2228947_51 TIM-barrel fold metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000005827 211.0
TLS2_k127_2228947_52 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000006555 222.0
TLS2_k127_2228947_53 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000000000000001139 184.0
TLS2_k127_2228947_54 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000001205 191.0
TLS2_k127_2228947_55 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.000000000000000000000000000000000000000000000000008941 184.0
TLS2_k127_2228947_56 response to oxidative stress - - - 0.000000000000000000000000000000000000000000000004328 176.0
TLS2_k127_2228947_57 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000000000008933 197.0
TLS2_k127_2228947_58 - - - - 0.00000000000000000000000000000000000000000000007517 177.0
TLS2_k127_2228947_59 Thioesterase - - - 0.00000000000000000000000000000000000000000001797 182.0
TLS2_k127_2228947_6 Thiolase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 565.0
TLS2_k127_2228947_60 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.0000000000000000000000000000000000000000003163 179.0
TLS2_k127_2228947_61 - - - - 0.000000000000000000000000000000000000000005537 164.0
TLS2_k127_2228947_62 - - - - 0.00000000000000000000000000000000000000001365 162.0
TLS2_k127_2228947_63 MaoC like domain - - - 0.0000000000000000000000000000000000000002121 155.0
TLS2_k127_2228947_64 - - - - 0.0000000000000000000000000000000000000004811 154.0
TLS2_k127_2228947_65 Protein of unknown function (DUF1489) - - - 0.0000000000000000000000000000000002034 151.0
TLS2_k127_2228947_66 HD domain - - - 0.0000000000000000000000000000000006357 145.0
TLS2_k127_2228947_67 MltA-interacting protein MipA K07274 - - 0.00000000000000000007159 99.0
TLS2_k127_2228947_68 Phasin protein - - - 0.0000000000000000001912 95.0
TLS2_k127_2228947_69 Histidine Phosphotransfer domain - - - 0.0000000000000000005233 96.0
TLS2_k127_2228947_7 Psort location Cytoplasmic, score 7.50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 545.0
TLS2_k127_2228947_70 Histidine kinase - - - 0.0002875 51.0
TLS2_k127_2228947_8 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 541.0
TLS2_k127_2228947_9 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006534 549.0
TLS2_k127_2230146_0 protein conserved in bacteria K09989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000788 618.0
TLS2_k127_2230146_1 SMP-30/Gluconolaconase/LRE-like region K01053,K14274 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 602.0
TLS2_k127_2230146_10 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 377.0
TLS2_k127_2230146_11 Ligated ion channel L-glutamate- and glycine-binding site K10018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 361.0
TLS2_k127_2230146_12 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 381.0
TLS2_k127_2230146_13 COG3959 Transketolase, N-terminal subunit K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 347.0
TLS2_k127_2230146_14 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 310.0
TLS2_k127_2230146_15 Binding-protein-dependent transport system inner membrane component K02029,K10020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 313.0
TLS2_k127_2230146_16 phytanoyl-CoA dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576 307.0
TLS2_k127_2230146_17 Binding-protein-dependent transport system inner membrane component K02029,K10019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005861 288.0
TLS2_k127_2230146_18 VirC1 protein K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002071 280.0
TLS2_k127_2230146_19 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003669 261.0
TLS2_k127_2230146_2 Cytidylyltransferase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 593.0
TLS2_k127_2230146_20 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000005392 237.0
TLS2_k127_2230146_21 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.000000000000000000000000000000000000000000000000000000000561 206.0
TLS2_k127_2230146_22 SIS domain - - - 0.000000000000000000000000000000000000000000000000000002661 199.0
TLS2_k127_2230146_23 PFAM Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000001285 173.0
TLS2_k127_2230146_24 - - - - 0.00000000000000000000000000000000005974 139.0
TLS2_k127_2230146_25 RmlD substrate binding domain - - - 0.00000000000000000000000000007895 130.0
TLS2_k127_2230146_26 Transposase and inactivated K07494 - - 0.0000000001056 62.0
TLS2_k127_2230146_3 Beta-eliminating lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 552.0
TLS2_k127_2230146_4 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 494.0
TLS2_k127_2230146_5 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 471.0
TLS2_k127_2230146_6 decarboxylase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009583 446.0
TLS2_k127_2230146_7 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 432.0
TLS2_k127_2230146_8 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K10021,K10025 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007008 408.0
TLS2_k127_2230146_9 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 407.0
TLS2_k127_2236213_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1028.0
TLS2_k127_2236213_1 Glycosyl transferase family 21 K03669 GO:0005575,GO:0016020 - 4.285e-261 844.0
TLS2_k127_2236213_10 Response regulator receiver K11443 - - 0.00000000000000000000000000000000000000000000000000000000000006818 218.0
TLS2_k127_2236213_11 UMP catabolic process - - - 0.000000000000000000000000000000000000000000000000000000004212 213.0
TLS2_k127_2236213_12 Phytoene squalene synthetase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000003872 207.0
TLS2_k127_2236213_13 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000002634 202.0
TLS2_k127_2236213_14 Domain of unknown function (DUF1849) - - - 0.000000000000000000000000000000000000000000000001735 183.0
TLS2_k127_2236213_15 Nudix hydrolase - - - 0.00000000000000000000000000000000000000001679 173.0
TLS2_k127_2236213_16 Protein of unknown function (DUF983) - - - 0.0000000000000000000000000000000000000001572 173.0
TLS2_k127_2236213_17 diguanylate cyclase - - - 0.0000000000000000000000000000000000000001899 161.0
TLS2_k127_2236213_18 Protein of unknown function (DUF3572) - - - 0.0000000000000000000001601 100.0
TLS2_k127_2236213_19 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000000001714 97.0
TLS2_k127_2236213_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.693e-239 766.0
TLS2_k127_2236213_3 belongs to the aldehyde dehydrogenase family K09472,K12254 - 1.2.1.54,1.2.1.99 1.454e-233 732.0
TLS2_k127_2236213_4 Periplasmic glucan biosynthesis protein, MdoG K03670 GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576 - 5.335e-197 630.0
TLS2_k127_2236213_5 diguanylate cyclase K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 517.0
TLS2_k127_2236213_6 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 510.0
TLS2_k127_2236213_7 ROK family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007145 406.0
TLS2_k127_2236213_8 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 312.0
TLS2_k127_2236213_9 DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001449 254.0
TLS2_k127_2249863_0 Cysteine synthase K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 543.0
TLS2_k127_2249863_1 NAD FAD-binding protein K06954 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 462.0
TLS2_k127_2249863_10 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896 3.6.1.13 0.000000000000000000000000000000000000000000000002042 196.0
TLS2_k127_2249863_11 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000004965 168.0
TLS2_k127_2249863_12 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000004752 156.0
TLS2_k127_2249863_13 FR47-like protein - - - 0.0000000000000000000000000000000000007225 143.0
TLS2_k127_2249863_14 Hemimethylated DNA-binding protein YccV like K11940 - - 0.00000000000000000000000000000000002963 140.0
TLS2_k127_2249863_15 Domain of unknown function (DUF4864) - - - 0.000000000000000000000000000000004013 135.0
TLS2_k127_2249863_16 SnoaL-like domain - - - 0.00000000000000000000000000003221 134.0
TLS2_k127_2249863_2 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 463.0
TLS2_k127_2249863_3 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 452.0
TLS2_k127_2249863_4 Sodium/hydrogen exchanger family K03316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 419.0
TLS2_k127_2249863_5 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 314.0
TLS2_k127_2249863_6 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005415 307.0
TLS2_k127_2249863_7 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002979 276.0
TLS2_k127_2249863_8 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005129 259.0
TLS2_k127_2249863_9 ChrR Cupin-like domain K07167 - - 0.0000000000000000000000000000000000000000000000000001229 195.0
TLS2_k127_2281968_0 Belongs to the heme-copper respiratory oxidase family K00404 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 1.493e-275 855.0
TLS2_k127_2281968_1 IG-like fold at C-terminal of FixG, putative oxidoreductase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 582.0
TLS2_k127_2281968_2 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 481.0
TLS2_k127_2281968_3 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 372.0
TLS2_k127_2281968_4 N-terminal domain of cytochrome oxidase-cbb3, FixP K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 340.0
TLS2_k127_2281968_5 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000008166 267.0
TLS2_k127_2281968_6 Sel1-like repeats. K07126,K13582 - - 0.0000000000000000000000000000000000000000000003518 178.0
TLS2_k127_2281968_7 FixH - - - 0.0000000000000000000305 102.0
TLS2_k127_2281968_8 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.0000000000003999 70.0
TLS2_k127_2284369_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.139e-269 852.0
TLS2_k127_2284369_1 COG1960 Acyl-CoA dehydrogenases K00248 - 1.3.8.1 6.568e-269 841.0
TLS2_k127_2284369_10 Belongs to the enoyl-CoA hydratase isomerase family K01692,K13766 - 4.2.1.17,4.2.1.18 0.00000000000000003099 94.0
TLS2_k127_2284369_11 - - - - 0.000000000005559 68.0
TLS2_k127_2284369_2 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K13777 - 6.4.1.5 8.709e-213 692.0
TLS2_k127_2284369_3 Belongs to the thiolase family K00626 - 2.3.1.9 7.604e-204 644.0
TLS2_k127_2284369_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 565.0
TLS2_k127_2284369_5 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 545.0
TLS2_k127_2284369_6 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 521.0
TLS2_k127_2284369_7 alcohol dehydrogenase K07119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 385.0
TLS2_k127_2284369_8 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001946 252.0
TLS2_k127_2284369_9 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000132 132.0
TLS2_k127_229444_0 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 586.0
TLS2_k127_229444_1 Belongs to the amidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 475.0
TLS2_k127_229444_2 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 470.0
TLS2_k127_229444_3 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008696 424.0
TLS2_k127_229444_4 DNA restriction-modification system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009914 421.0
TLS2_k127_229444_5 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001868 248.0
TLS2_k127_229444_6 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000007843 216.0
TLS2_k127_229444_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000009672 203.0
TLS2_k127_229444_8 - - - - 0.00000001359 60.0
TLS2_k127_229444_9 - - - - 0.00004268 57.0
TLS2_k127_2305171_0 Belongs to the IlvD Edd family K13875 - 4.2.1.25 9.125e-250 790.0
TLS2_k127_2305171_1 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 462.0
TLS2_k127_2305171_10 Diguanylate phosphodiesterase K13593 - - 0.000000000000000000000000000000000000000000000000000000000000009097 231.0
TLS2_k127_2305171_11 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000002058 217.0
TLS2_k127_2305171_12 decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000001446 181.0
TLS2_k127_2305171_14 Rubrerythrin K05919,K07798 - 1.15.1.2 0.00000000000000096 80.0
TLS2_k127_2305171_15 Protein of unknown function (DUF3224) - - - 0.00000000002147 73.0
TLS2_k127_2305171_16 Transposase IS200 like K07491 - - 0.00001681 50.0
TLS2_k127_2305171_17 Transposase - - - 0.0001991 51.0
TLS2_k127_2305171_2 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 443.0
TLS2_k127_2305171_3 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 350.0
TLS2_k127_2305171_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 331.0
TLS2_k127_2305171_5 Enoyl-(Acyl carrier protein) reductase K00019,K18335 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009037 324.0
TLS2_k127_2305171_6 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000007591 273.0
TLS2_k127_2305171_7 short-chain dehydrogenase K05296 - 1.1.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000002077 249.0
TLS2_k127_2305171_8 sugar phosphatases of the HAD superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000001454 248.0
TLS2_k127_2305171_9 Transposase IS200 like K07491 - - 0.000000000000000000000000000000000000000000000000000000000000003037 225.0
TLS2_k127_2305347_0 cellulose binding - - - 1.809e-249 826.0
TLS2_k127_2305347_1 homolog of phage Mu protein gp47 - - - 1.071e-242 777.0
TLS2_k127_2305347_10 Baseplate assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000002901 255.0
TLS2_k127_2305347_11 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000000000000000002302 216.0
TLS2_k127_2305347_12 Protein conserved in bacteria K04750 - - 0.00000000000000000000000000000000000000000000000000000000009073 209.0
TLS2_k127_2305347_13 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000001391 218.0
TLS2_k127_2305347_14 - - - - 0.00000000000000000000000000000000000000000000000000007005 199.0
TLS2_k127_2305347_15 Gene 25-like lysozyme K06903 - - 0.0000000000000000000000000000000003975 135.0
TLS2_k127_2305347_16 - - - - 0.0000000000000000000000000000000009448 140.0
TLS2_k127_2305347_17 - - - - 0.00000000000000000002364 102.0
TLS2_k127_2305347_2 Two component regulator propeller - - - 6.27e-198 649.0
TLS2_k127_2305347_3 Phage tail sheath C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 571.0
TLS2_k127_2305347_4 protein, phage tail-like region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006702 543.0
TLS2_k127_2305347_5 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 490.0
TLS2_k127_2305347_6 Lytic murein transglycosylase K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 404.0
TLS2_k127_2305347_7 Protein of unknown function (DUF4255) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004905 306.0
TLS2_k127_2305347_8 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 306.0
TLS2_k127_2305347_9 Late control gene D protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001494 249.0
TLS2_k127_2322879_0 electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 6.522e-260 813.0
TLS2_k127_2322879_1 Capsule biosynthesis GfcC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005938 590.0
TLS2_k127_2322879_2 Exopolysaccharide biosynthesis protein YbjH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 493.0
TLS2_k127_2322879_3 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008477 443.0
TLS2_k127_2322879_4 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000001279 258.0
TLS2_k127_2322879_5 carboxymethylenebutenolidase activity K01061,K22249 - 3.1.1.45,3.1.1.76 0.0000000000000000000000000000001154 142.0
TLS2_k127_2322879_6 Lipoprotein - GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576 - 0.00000000000000000000000002365 117.0
TLS2_k127_2322879_7 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00002409 48.0
TLS2_k127_2331338_0 Adenylate cyclase K01768 - 4.6.1.1 2.325e-195 619.0
TLS2_k127_2331338_1 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 486.0
TLS2_k127_2331338_2 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 424.0
TLS2_k127_2331338_3 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 429.0
TLS2_k127_2331338_4 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K01872,K07050 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 379.0
TLS2_k127_2331338_5 phosphoesterase, PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000425 220.0
TLS2_k127_2331338_6 Peptidase A4 family - - - 0.00000000000000000000000000000000000000000000000000000003311 209.0
TLS2_k127_2331338_7 DsbA oxidoreductase - - - 0.000000000000000000000000000000000000000000008672 169.0
TLS2_k127_2331338_8 PFAM Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000001708 127.0
TLS2_k127_2356370_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 577.0
TLS2_k127_2356370_1 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 602.0
TLS2_k127_2356370_10 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000104 162.0
TLS2_k127_2356370_12 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.000000000000000000000000000000002404 148.0
TLS2_k127_2356370_13 - - - - 0.00000000000000000000000000001348 132.0
TLS2_k127_2356370_2 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 442.0
TLS2_k127_2356370_3 alcohol dehydrogenase K13954 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006323 443.0
TLS2_k127_2356370_4 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 395.0
TLS2_k127_2356370_5 branched-chain amino acid K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 375.0
TLS2_k127_2356370_6 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001759 243.0
TLS2_k127_2356370_7 NIPSNAP - - - 0.00000000000000000000000000000000000000000000000000000000001601 213.0
TLS2_k127_2356370_8 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000000000000000000000000000000000000000000000000009493 199.0
TLS2_k127_2356370_9 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.0000000000000000000000000000000000000000000000000000149 205.0
TLS2_k127_2365356_0 CHASE2 K01768 - 4.6.1.1 1.524e-213 687.0
TLS2_k127_2365356_1 Type II/IV secretion system protein K02283 - - 4.782e-194 612.0
TLS2_k127_2365356_10 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.0000000000000000000000000000000000000000000859 167.0
TLS2_k127_2365356_11 MlaA lipoprotein K04754 - - 0.000000000000000000000000000000000000000006805 177.0
TLS2_k127_2365356_12 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.0000000000000000000000000000000000000001965 168.0
TLS2_k127_2365356_13 Pilus assembly protein CpaB K02279 - - 0.000000000000000000007351 107.0
TLS2_k127_2365356_14 Flp Fap pilin component K02651 - - 0.000000009245 61.0
TLS2_k127_2365356_15 TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD K02281 - - 0.00000005129 64.0
TLS2_k127_2365356_16 peptidase K02278 - 3.4.23.43 0.0000003299 59.0
TLS2_k127_2365356_2 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005267 441.0
TLS2_k127_2365356_3 Bacterial type II and III secretion system protein K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 398.0
TLS2_k127_2365356_4 Belongs to the mandelate racemase muconate lactonizing enzyme family K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 384.0
TLS2_k127_2365356_5 AAA domain K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 383.0
TLS2_k127_2365356_6 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 307.0
TLS2_k127_2365356_7 Response regulator containing a CheY-like receiver domain and an HD-GYP domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000001534 219.0
TLS2_k127_2365356_8 Psort location Extracellular, score - - - 0.0000000000000000000000000000000000000000000000000327 198.0
TLS2_k127_2365356_9 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000005454 169.0
TLS2_k127_2413800_0 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 4.892e-291 914.0
TLS2_k127_2413800_1 Peptidase dimerisation domain K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 612.0
TLS2_k127_2413800_10 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000004037 52.0
TLS2_k127_2413800_2 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 448.0
TLS2_k127_2413800_3 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 364.0
TLS2_k127_2413800_4 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 318.0
TLS2_k127_2413800_5 Belongs to the urease beta subunit family K01429 - 3.5.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000191 280.0
TLS2_k127_2413800_6 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.00000000000000000000000000000000000000000000000005549 189.0
TLS2_k127_2413800_7 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.0000000000000000000000000000000000000000000003444 172.0
TLS2_k127_2413800_8 Bacterial signalling protein N terminal repeat - - - 0.0000000000000000000000000003006 119.0
TLS2_k127_2413800_9 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.000000000000000000005236 102.0
TLS2_k127_2437919_0 (ABC) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 596.0
TLS2_k127_2437919_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 562.0
TLS2_k127_2437919_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 454.0
TLS2_k127_2437919_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 353.0
TLS2_k127_2437919_4 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 315.0
TLS2_k127_2437919_5 - - - - 0.00000000000000000000000000000000000000000000000000000002137 206.0
TLS2_k127_2437919_6 Methyltransferase FkbM family - - - 0.0000000000000000000000000000000000000000000009314 174.0
TLS2_k127_2437919_7 methyltransferase - - - 0.00000000000000000000004257 102.0
TLS2_k127_2437919_8 Chain length determinant protein - - - 0.00000000001848 75.0
TLS2_k127_2456783_0 Fibronectin type III-like domain K05349 - 3.2.1.21 7.976e-216 695.0
TLS2_k127_2456783_1 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 496.0
TLS2_k127_2456783_2 Putative glucoamylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005565 327.0
TLS2_k127_2459043_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00612 - - 1.563e-290 901.0
TLS2_k127_2459043_1 COG0010 Arginase agmatinase formimionoglutamate hydrolase, arginase family K18459 - 3.5.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 537.0
TLS2_k127_2459043_10 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005078 283.0
TLS2_k127_2459043_11 Inositol monophosphatase family K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000001467 264.0
TLS2_k127_2459043_12 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000005287 241.0
TLS2_k127_2459043_13 - - - - 0.0000000000000000000000000000000000000000004143 162.0
TLS2_k127_2459043_14 Protein of unknown function (DUF1491) - - - 0.00000000000000000000000000001278 128.0
TLS2_k127_2459043_16 Glycosyl transferases group 1 - - - 0.00000000000000000000001147 107.0
TLS2_k127_2459043_17 lipolytic protein G-D-S-L family - - - 0.00000000000000000003498 102.0
TLS2_k127_2459043_18 - - - - 0.0000000000000001134 80.0
TLS2_k127_2459043_2 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 473.0
TLS2_k127_2459043_3 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 402.0
TLS2_k127_2459043_4 (LPS) heptosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007169 366.0
TLS2_k127_2459043_5 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 331.0
TLS2_k127_2459043_6 Phosphorylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009118 315.0
TLS2_k127_2459043_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 302.0
TLS2_k127_2459043_8 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007596 293.0
TLS2_k127_2459043_9 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 289.0
TLS2_k127_2461142_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.515e-296 923.0
TLS2_k127_2461142_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 7.143e-246 765.0
TLS2_k127_2461142_10 ubiquinone menaquinone biosynthesis methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007458 333.0
TLS2_k127_2461142_11 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 325.0
TLS2_k127_2461142_12 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 308.0
TLS2_k127_2461142_13 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009606 309.0
TLS2_k127_2461142_14 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 302.0
TLS2_k127_2461142_15 Belongs to the SfsA family K06206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 285.0
TLS2_k127_2461142_16 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006336 281.0
TLS2_k127_2461142_17 MaoC like domain - - - 0.00000000000000000000000000000000000000000001712 178.0
TLS2_k127_2461142_18 FR47-like protein - - - 0.00000000000000000000000000000000008553 140.0
TLS2_k127_2461142_19 Domain of unknown function (DUF1476) - - - 0.0000000000000000000000000000000006042 136.0
TLS2_k127_2461142_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 2.017e-212 666.0
TLS2_k127_2461142_20 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000002853 123.0
TLS2_k127_2461142_21 PRC-barrel domain - - - 0.000001389 53.0
TLS2_k127_2461142_3 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 1.018e-196 618.0
TLS2_k127_2461142_4 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 586.0
TLS2_k127_2461142_5 Acetyl-coenzyme A transporter 1 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 519.0
TLS2_k127_2461142_6 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 470.0
TLS2_k127_2461142_7 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 452.0
TLS2_k127_2461142_8 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 445.0
TLS2_k127_2461142_9 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 345.0
TLS2_k127_2641726_0 cytochrome C peroxidase - - - 5.743e-197 627.0
TLS2_k127_2641726_1 cytochrome C peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 482.0
TLS2_k127_2641726_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005804 286.0
TLS2_k127_2641726_3 Belongs to the 'phage' integrase family - - - 0.0000000000002621 74.0
TLS2_k127_2641726_4 Cytochrome c - - - 0.0001393 44.0
TLS2_k127_2665046_0 Fumarate reductase flavoprotein C-term - - - 2.269e-219 693.0
TLS2_k127_2665046_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 5.196e-210 661.0
TLS2_k127_2665046_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009355 573.0
TLS2_k127_2665046_3 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 383.0
TLS2_k127_2665046_4 Methylenetetrahydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 349.0
TLS2_k127_2665046_5 Aconitase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003705 254.0
TLS2_k127_2665046_6 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000059 138.0
TLS2_k127_2665046_7 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0004623 46.0
TLS2_k127_2715057_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 9.667e-287 886.0
TLS2_k127_2715057_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 442.0
TLS2_k127_2715057_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 320.0
TLS2_k127_2715057_3 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000003583 168.0
TLS2_k127_2715057_4 Domain of unknown function (DUF4383) - - - 0.00000000000000000000000000000000000009324 146.0
TLS2_k127_2715057_5 Protein of unknown function (DUF1013) K09987 - - 0.000000000000000000000000001703 118.0
TLS2_k127_2715057_6 Protein of unknown function (DUF1192) - - - 0.000001689 53.0
TLS2_k127_2734293_0 Biotin carboxylase C-terminal domain - - - 1.833e-276 864.0
TLS2_k127_2734293_1 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 500.0
TLS2_k127_2734293_2 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006697 482.0
TLS2_k127_2734293_3 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 453.0
TLS2_k127_2734293_4 PFAM Methionine synthase vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 396.0
TLS2_k127_2734293_5 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003394 285.0
TLS2_k127_2734293_6 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000000000002048 146.0
TLS2_k127_2734293_7 sulfate adenylyltransferase (ATP) activity K00957 - 2.7.7.4 0.000000000000247 82.0
TLS2_k127_2736202_0 FAD dependent oxidoreductase central domain - - - 2.555e-271 858.0
TLS2_k127_2736202_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.52e-246 774.0
TLS2_k127_2736202_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 2.761e-246 771.0
TLS2_k127_2736202_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 600.0
TLS2_k127_2736202_4 Arylsulfotransferase (ASST) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 562.0
TLS2_k127_2736202_5 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009398 521.0
TLS2_k127_2736202_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 334.0
TLS2_k127_2736202_7 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 285.0
TLS2_k127_2736202_8 Carboxylesterase family K01066 - - 0.00000000000000000001667 92.0
TLS2_k127_2736202_9 Parallel beta-helix repeats - - - 0.00000000000005451 74.0
TLS2_k127_2781241_0 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 7.566e-289 901.0
TLS2_k127_2781241_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.506e-228 711.0
TLS2_k127_2781241_10 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 357.0
TLS2_k127_2781241_11 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006547 347.0
TLS2_k127_2781241_12 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 309.0
TLS2_k127_2781241_13 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 297.0
TLS2_k127_2781241_14 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000001618 233.0
TLS2_k127_2781241_15 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000004804 207.0
TLS2_k127_2781241_16 PFAM conserved K08973 - - 0.00000000000000000000000000000000000000000000000000000007307 198.0
TLS2_k127_2781241_17 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000006908 202.0
TLS2_k127_2781241_18 LUD domain K00782 - - 0.00000000000000000000000000000000000000000000000000002134 212.0
TLS2_k127_2781241_19 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.00000000000000000000000000000000000000000000000002451 188.0
TLS2_k127_2781241_2 LUD domain K18929 - - 1.132e-197 627.0
TLS2_k127_2781241_20 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000008633 201.0
TLS2_k127_2781241_21 - - - - 0.00000000000000000000000000000000000000000000002008 184.0
TLS2_k127_2781241_22 COG3030 Protein affecting phage T7 exclusion by the F plasmid K07113 - - 0.000000000000000000000000000000004287 135.0
TLS2_k127_2781241_23 PFAM Smr protein MutS2 - - - 0.0000000000000000000002445 103.0
TLS2_k127_2781241_24 domain, Protein - - - 0.000000000000000005292 86.0
TLS2_k127_2781241_25 - - - - 0.0000000000315 68.0
TLS2_k127_2781241_3 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007713 606.0
TLS2_k127_2781241_4 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007205 464.0
TLS2_k127_2781241_5 NADPH quinone K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 429.0
TLS2_k127_2781241_6 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 415.0
TLS2_k127_2781241_7 membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 397.0
TLS2_k127_2781241_8 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008057 392.0
TLS2_k127_2781241_9 (Fe-S) oxidoreductase K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 364.0
TLS2_k127_280196_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 321.0
TLS2_k127_280196_1 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001169 237.0
TLS2_k127_280196_2 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000001298 241.0
TLS2_k127_280196_3 - - - - 0.0000000000000000000000000000000000000000000000000000003534 220.0
TLS2_k127_280196_4 Protein of unknown function, DUF393 - - - 0.000000000000000000000000000000000001285 143.0
TLS2_k127_2820950_0 FAD dependent oxidoreductase central domain K19191 - 1.5.3.19 0.0 1071.0
TLS2_k127_2820950_1 methylesterase K13924 - 2.1.1.80,3.1.1.61 1.496e-206 659.0
TLS2_k127_2820950_10 HWE histidine kinase - - - 0.000000000001728 79.0
TLS2_k127_2820950_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 494.0
TLS2_k127_2820950_3 Alanine racemase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 408.0
TLS2_k127_2820950_4 CheB methylesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 359.0
TLS2_k127_2820950_5 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005209 299.0
TLS2_k127_2820950_6 methylesterase K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000188 212.0
TLS2_k127_2820950_7 Methyltransferase - - - 0.000000000000000000000000000000000000000000002903 175.0
TLS2_k127_2820950_8 Histidine kinase - - - 0.000000000000000000000000000000000000000004591 176.0
TLS2_k127_2820950_9 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000002373 121.0
TLS2_k127_2847073_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 1.555e-278 904.0
TLS2_k127_2847073_1 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 2.574e-256 815.0
TLS2_k127_2847073_10 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001827 242.0
TLS2_k127_2847073_11 PFAM isochorismatase hydrolase K09020 - 3.5.1.110 0.000000000000000000000000000000000000000000000000000000000000000004579 255.0
TLS2_k127_2847073_12 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000003565 160.0
TLS2_k127_2847073_13 PIN domain - - - 0.000000000000000002691 93.0
TLS2_k127_2847073_14 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000004463 76.0
TLS2_k127_2847073_15 FecR protein - - - 0.0000000000007774 78.0
TLS2_k127_2847073_2 belongs to the aldehyde dehydrogenase family K00128,K06447 - 1.2.1.3,1.2.1.71 1.531e-200 640.0
TLS2_k127_2847073_3 CoA-binding domain protein - - - 1.197e-199 651.0
TLS2_k127_2847073_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000988 488.0
TLS2_k127_2847073_5 transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 361.0
TLS2_k127_2847073_6 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 352.0
TLS2_k127_2847073_7 Domain of unknown function DUF108 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 322.0
TLS2_k127_2847073_8 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 303.0
TLS2_k127_2847073_9 biosynthesis protein E K06139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002271 240.0
TLS2_k127_2877217_0 ABC transporter substrate-binding protein PnrA-like K02058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 525.0
TLS2_k127_2877217_1 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 480.0
TLS2_k127_2877217_2 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 471.0
TLS2_k127_2877217_3 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 362.0
TLS2_k127_2877217_4 (ABC) transporter K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000002 229.0
TLS2_k127_2917631_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 1.046e-229 744.0
TLS2_k127_2917631_1 - - - - 1.678e-226 719.0
TLS2_k127_2917631_10 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 377.0
TLS2_k127_2917631_11 Mitochondrial fission ELM1 K07276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 355.0
TLS2_k127_2917631_12 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006775 338.0
TLS2_k127_2917631_13 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002675 276.0
TLS2_k127_2917631_14 Protein of unknown function (DUF1513) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001087 256.0
TLS2_k127_2917631_15 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000007496 243.0
TLS2_k127_2917631_16 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000613 229.0
TLS2_k127_2917631_17 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000002052 218.0
TLS2_k127_2917631_18 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000001748 175.0
TLS2_k127_2917631_19 NfeD-like C-terminal, partner-binding K07340 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000116 177.0
TLS2_k127_2917631_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008482 588.0
TLS2_k127_2917631_20 - - - - 0.0000000000000000000000000000000000000005002 158.0
TLS2_k127_2917631_21 Iron-binding zinc finger CDGSH type - - - 0.0000000000000000000000000000005715 138.0
TLS2_k127_2917631_22 EamA-like transporter family - - - 0.00000000000000000000000000001348 130.0
TLS2_k127_2917631_23 Protein of unknown function (DUF962) - - - 0.00000000000000000000000003649 121.0
TLS2_k127_2917631_24 - - - - 0.00000000000000000004802 97.0
TLS2_k127_2917631_25 - - - - 0.000000000004174 72.0
TLS2_k127_2917631_3 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 481.0
TLS2_k127_2917631_4 Glycine cleavage system T protein K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 475.0
TLS2_k127_2917631_5 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 464.0
TLS2_k127_2917631_6 Oxidoreductase molybdopterin binding K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008511 448.0
TLS2_k127_2917631_7 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 484.0
TLS2_k127_2917631_8 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 430.0
TLS2_k127_2917631_9 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 391.0
TLS2_k127_2927453_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2148.0
TLS2_k127_2967889_0 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 605.0
TLS2_k127_2967889_1 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 511.0
TLS2_k127_2967889_10 Domain of unknown function (DUF4384) - - - 0.00000005235 66.0
TLS2_k127_2967889_2 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01459 - 3.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 489.0
TLS2_k127_2967889_3 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 488.0
TLS2_k127_2967889_4 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004509 500.0
TLS2_k127_2967889_5 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 474.0
TLS2_k127_2967889_6 Pyridoxal-phosphate dependent enzyme K01751 - 4.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009804 449.0
TLS2_k127_2967889_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 428.0
TLS2_k127_2967889_8 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 385.0
TLS2_k127_2967889_9 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 353.0
TLS2_k127_2976353_0 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 6.382e-221 697.0
TLS2_k127_2976353_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 576.0
TLS2_k127_2976353_10 1-phosphatidylinositol-4-phosphate 5-kinase activity - - - 0.0000000000000000000000000581 121.0
TLS2_k127_2976353_2 ATPase with chaperone activity K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 481.0
TLS2_k127_2976353_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 471.0
TLS2_k127_2976353_4 Periplasmic binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 330.0
TLS2_k127_2976353_5 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008305 307.0
TLS2_k127_2976353_6 COG0778 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 331.0
TLS2_k127_2976353_7 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000005482 205.0
TLS2_k127_2976353_8 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000000000000000000000006479 176.0
TLS2_k127_2976353_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000006264 116.0
TLS2_k127_298307_0 DNA-binding domain of Proline dehydrogenase K13821 - 1.2.1.88,1.5.5.2 0.0 1200.0
TLS2_k127_298307_1 2Fe-2S iron-sulfur cluster binding domain K22086 - 1.5.99.5 0.0 1027.0
TLS2_k127_298307_10 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 580.0
TLS2_k127_298307_11 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 529.0
TLS2_k127_298307_12 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 557.0
TLS2_k127_298307_13 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 524.0
TLS2_k127_298307_14 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 519.0
TLS2_k127_298307_15 Selenocysteine synthase N terminal K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 523.0
TLS2_k127_298307_16 Periplasmic binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 518.0
TLS2_k127_298307_17 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 463.0
TLS2_k127_298307_18 MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007053 436.0
TLS2_k127_298307_19 Glycosyl transferase family 41 K09667 - 2.4.1.255 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 450.0
TLS2_k127_298307_2 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 2.459e-244 771.0
TLS2_k127_298307_20 FAD binding domain K00480 - 1.14.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 428.0
TLS2_k127_298307_21 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 388.0
TLS2_k127_298307_22 D-isomer specific 2-hydroxyacid dehydrogenase K00018 - 1.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 388.0
TLS2_k127_298307_23 Flagella basal body rod protein K02392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 371.0
TLS2_k127_298307_24 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 356.0
TLS2_k127_298307_25 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 357.0
TLS2_k127_298307_26 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 349.0
TLS2_k127_298307_27 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 348.0
TLS2_k127_298307_28 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 324.0
TLS2_k127_298307_29 Nitrile hydratase, alpha chain K01721,K20807 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005698 302.0
TLS2_k127_298307_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 2.237e-241 780.0
TLS2_k127_298307_30 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 325.0
TLS2_k127_298307_31 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000034 286.0
TLS2_k127_298307_32 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000009254 260.0
TLS2_k127_298307_33 Pentapeptide repeats (9 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006564 287.0
TLS2_k127_298307_34 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001642 256.0
TLS2_k127_298307_35 Caspase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001664 265.0
TLS2_k127_298307_36 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000846 252.0
TLS2_k127_298307_37 Belongs to the flagella basal body rod proteins family K02391 - - 0.000000000000000000000000000000000000000000000000000000000000005514 230.0
TLS2_k127_298307_38 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000000000000000000000000001506 214.0
TLS2_k127_298307_39 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000000000000000005229 180.0
TLS2_k127_298307_4 Malate synthase - - - 4.756e-237 743.0
TLS2_k127_298307_40 Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK K06601 - - 0.00000000000000000000000000000000000000000002342 168.0
TLS2_k127_298307_41 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000006878 185.0
TLS2_k127_298307_42 Sarcosine oxidase, gamma subunit K22087 - 1.5.99.5 0.0000000000000000000000000000000000000000006114 164.0
TLS2_k127_298307_43 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.0000000000000000000000000000000000000004045 154.0
TLS2_k127_298307_44 - - - - 0.00000000000000000000000000000000000003797 152.0
TLS2_k127_298307_45 Selenoprotein B glycine betaine sarcosine D-proline reductase K10794 - 1.21.4.1 0.000000000000000000000000000000000001292 143.0
TLS2_k127_298307_46 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.000000000000000000000000000000000001886 141.0
TLS2_k127_298307_47 protein conserved in bacteria K09790 - - 0.00000000000000000000000000000001015 131.0
TLS2_k127_298307_48 Sarcosine oxidase, delta subunit family K22085 - 1.5.99.5 0.0000000000000000000000000000001264 125.0
TLS2_k127_298307_49 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.000000000000000000000000000000745 123.0
TLS2_k127_298307_5 AIR synthase related protein, C-terminal domain - - - 1.897e-209 678.0
TLS2_k127_298307_50 PFAM response regulator receiver - - - 0.000000000000000000000000002688 115.0
TLS2_k127_298307_51 - - - - 0.000000000000000000000000006666 112.0
TLS2_k127_298307_52 Flagellar protein FlaF K06602 - - 0.00000000000000000000000001052 112.0
TLS2_k127_298307_53 Proteolipid membrane potential modulator - - - 0.00000000000000000000001269 100.0
TLS2_k127_298307_54 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000000000000004407 104.0
TLS2_k127_298307_55 - - - - 0.00000000000000001297 84.0
TLS2_k127_298307_56 CopG domain protein DNA-binding domain protein K18918 - - 0.0000000000000000786 83.0
TLS2_k127_298307_57 flagellar assembly - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000002747 84.0
TLS2_k127_298307_58 Rod binding protein - - - 0.00000000002475 76.0
TLS2_k127_298307_59 flagella basal body P-ring formation protein FlgA K02386 - - 0.00000000003017 76.0
TLS2_k127_298307_6 FAD dependent oxidoreductase K22084 - 1.5.99.5 8.938e-208 653.0
TLS2_k127_298307_60 Pentapeptide repeats (9 copies) - - - 0.000000000043 71.0
TLS2_k127_298307_61 - - - - 0.000000000364 70.0
TLS2_k127_298307_63 flagellar protein FlaG K06603 - - 0.00001705 54.0
TLS2_k127_298307_64 - - - - 0.0008427 51.0
TLS2_k127_298307_7 cysteine synthase K01697 - 4.2.1.22 7.803e-205 654.0
TLS2_k127_298307_8 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 597.0
TLS2_k127_298307_9 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01758 - 4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009799 612.0
TLS2_k127_2985175_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1553.0
TLS2_k127_2985175_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 7.101e-273 859.0
TLS2_k127_2985175_10 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 565.0
TLS2_k127_2985175_11 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 494.0
TLS2_k127_2985175_12 PFAM Hydantoinase B oxoprolinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006182 522.0
TLS2_k127_2985175_13 Belongs to the RimK family K05844,K14940 - 6.3.2.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009617 476.0
TLS2_k127_2985175_14 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005839 481.0
TLS2_k127_2985175_15 Protein of unknown function (DUF1688) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 449.0
TLS2_k127_2985175_16 succinylglutamate desuccinylase K06987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 430.0
TLS2_k127_2985175_17 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 420.0
TLS2_k127_2985175_18 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 412.0
TLS2_k127_2985175_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 409.0
TLS2_k127_2985175_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 1.085e-261 814.0
TLS2_k127_2985175_20 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 405.0
TLS2_k127_2985175_21 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009279 424.0
TLS2_k127_2985175_22 COG0044 Dihydroorotase and related cyclic amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 376.0
TLS2_k127_2985175_23 N-terminal domain of oxidoreductase K07119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 394.0
TLS2_k127_2985175_24 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 383.0
TLS2_k127_2985175_25 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009669 317.0
TLS2_k127_2985175_26 Uracil phosphoribosyltransferase K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 312.0
TLS2_k127_2985175_27 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009273 297.0
TLS2_k127_2985175_28 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006798 271.0
TLS2_k127_2985175_29 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006541 273.0
TLS2_k127_2985175_3 amp-dependent synthetase K01895 - 6.2.1.1 1.195e-251 786.0
TLS2_k127_2985175_30 helix_turn_helix isocitrate lyase regulation K13641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004264 271.0
TLS2_k127_2985175_31 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002821 255.0
TLS2_k127_2985175_32 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001382 238.0
TLS2_k127_2985175_33 Domain of unknown function (DUF4863) - - - 0.000000000000000000000000000000000000000000000000000000000000000003485 231.0
TLS2_k127_2985175_34 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000001283 236.0
TLS2_k127_2985175_35 PRC-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000002446 224.0
TLS2_k127_2985175_36 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000006898 224.0
TLS2_k127_2985175_37 Bacterial protein of unknown function (DUF882) - - - 0.000000000000000000000000000000000000000000000000000000004718 204.0
TLS2_k127_2985175_38 Ribosomal protein S6 modification protein - - - 0.0000000000000000000000000000000000000000000000000086 186.0
TLS2_k127_2985175_39 Helix-turn-helix K21498 - - 0.00000000000000000000000000000000000000000000002295 173.0
TLS2_k127_2985175_4 Belongs to the TPP enzyme family K01576 - 4.1.1.7 4.403e-218 690.0
TLS2_k127_2985175_40 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000009698 171.0
TLS2_k127_2985175_41 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000002903 175.0
TLS2_k127_2985175_42 PFAM GCN5-related N-acetyltransferase K03830 - - 0.00000000000000000000000000000000000000000002981 168.0
TLS2_k127_2985175_43 Protein of unknown function (DUF1244) K09948 - - 0.000000000000000000000000000000000000000007821 155.0
TLS2_k127_2985175_44 cyclopropane-fatty-acyl-phospholipid synthase - - - 0.000000000000000000000000000000000000004336 158.0
TLS2_k127_2985175_45 YHS domain protein - - - 0.000000000000000000000000000000000000006999 162.0
TLS2_k127_2985175_46 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000103 151.0
TLS2_k127_2985175_47 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.0000000000000000000000003556 107.0
TLS2_k127_2985175_48 Uncharacterized protein conserved in bacteria (DUF2312) - - - 0.00000000000000000000001134 108.0
TLS2_k127_2985175_49 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000003887 72.0
TLS2_k127_2985175_5 TRAP transporter, 4TM 12TM fusion protein - - - 5.327e-206 655.0
TLS2_k127_2985175_50 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K01768 - 4.6.1.1 0.0000000002727 63.0
TLS2_k127_2985175_51 ABC transporter - - - 0.00001358 57.0
TLS2_k127_2985175_6 GTP cyclohydrolase N terminal - - - 3.606e-198 625.0
TLS2_k127_2985175_7 Cysteine-rich domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 606.0
TLS2_k127_2985175_8 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 590.0
TLS2_k127_2985175_9 Hydantoinase/oxoprolinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 583.0
TLS2_k127_2986951_0 COG3263 NhaP-type Na H and K H antiporters with a unique C-terminal domain K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 609.0
TLS2_k127_2986951_1 L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 312.0
TLS2_k127_2986951_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001101 295.0
TLS2_k127_2986951_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000007524 161.0
TLS2_k127_3010730_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1235.0
TLS2_k127_3010730_1 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 6.657e-235 730.0
TLS2_k127_3010730_10 Role in flagellar biosynthesis K02421 - - 0.000000000000000000000000000000000000000000000000000000000000001056 232.0
TLS2_k127_3010730_11 In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media - - - 0.000000000000000000000000000000000000000000000000000000000001133 220.0
TLS2_k127_3010730_12 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000000001052 185.0
TLS2_k127_3010730_13 Belongs to the flagella basal body rod proteins family K02388 - - 0.00000000000000000000000000000000000000000004462 171.0
TLS2_k127_3010730_14 - - - - 0.000000000000000000000000000000000000001474 164.0
TLS2_k127_3010730_15 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.0000000000000000000000001152 111.0
TLS2_k127_3010730_16 Flagellar biosynthesis K02420 - - 0.0000000000000000000000007629 106.0
TLS2_k127_3010730_17 flagellar K02418 - - 0.0000000000000003506 83.0
TLS2_k127_3010730_18 Flagellar hook-basal body complex protein FliE K02408 - - 0.00000000000001159 78.0
TLS2_k127_3010730_2 signal transduction histidine kinase K13587 - 2.7.13.3 1.518e-218 704.0
TLS2_k127_3010730_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000778 581.0
TLS2_k127_3010730_4 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 436.0
TLS2_k127_3010730_5 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 346.0
TLS2_k127_3010730_6 Plays a role in the flagellum-specific transport system K02419 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 316.0
TLS2_k127_3010730_7 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 295.0
TLS2_k127_3010730_8 Protein-glutamate methylesterase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000001274 259.0
TLS2_k127_3010730_9 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000004572 234.0
TLS2_k127_3018771_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 391.0
TLS2_k127_3018771_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 369.0
TLS2_k127_3018771_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 331.0
TLS2_k127_3018771_3 His Kinase A (phosphoacceptor) domain K07716,K11357 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000943 243.0
TLS2_k127_3018771_4 Methylmuconolactone methyl-isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000648 219.0
TLS2_k127_3021440_0 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005931 497.0
TLS2_k127_3021440_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006327 507.0
TLS2_k127_3021440_2 Belongs to the GST superfamily K11209 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016667,GO:0050896,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 356.0
TLS2_k127_3021440_3 hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000003556 215.0
TLS2_k127_3021440_4 YbaK prolyl-tRNA synthetase associated - - - 0.000000000000000000000000000000000000007922 158.0
TLS2_k127_3051063_0 Luciferase-like monooxygenase - - - 1.628e-204 644.0
TLS2_k127_3051063_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 506.0
TLS2_k127_3051063_2 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000000000009233 207.0
TLS2_k127_3051063_3 RTX toxins and related Ca2 binding proteins - - - 0.0000000000000000000000000000000000000000000000000000001631 212.0
TLS2_k127_3051063_4 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 0.00000000000000000000000000000000000000000000000003106 187.0
TLS2_k127_3051063_5 invasion associated locus B - - - 0.0000000000000000000000000000000003139 151.0
TLS2_k127_3051063_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000002532 131.0
TLS2_k127_3051063_7 relative of glutathione S-transferase, MAPEG superfamily K07136 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000002265 118.0
TLS2_k127_3051063_8 Desulfoferrodoxin - - - 0.0000000000000000000025 100.0
TLS2_k127_3058903_0 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases K02230 - 6.6.1.2 0.0 1484.0
TLS2_k127_3058903_1 Flavin-binding monooxygenase-like K03379,K21730 - 1.14.13.160,1.14.13.22 9.292e-268 840.0
TLS2_k127_3058903_10 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.00000000000000000000000000000000000000000000000001874 188.0
TLS2_k127_3058903_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 2.605e-199 631.0
TLS2_k127_3058903_3 CbiX - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 459.0
TLS2_k127_3058903_4 Cobalamin synthesis protein cobW C-terminal domain K02234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 455.0
TLS2_k127_3058903_5 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008955 389.0
TLS2_k127_3058903_6 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 323.0
TLS2_k127_3058903_7 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 312.0
TLS2_k127_3058903_8 Cob(I)alamin adenosyltransferase N terminal K19221 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 307.0
TLS2_k127_3058903_9 Precorrin-6Y C5,15-methyltransferase K00595 - 2.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000006235 282.0
TLS2_k127_3088268_0 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 619.0
TLS2_k127_3088268_1 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005087 531.0
TLS2_k127_3088268_10 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000001516 68.0
TLS2_k127_3088268_11 Alpha/beta hydrolase family K06889 - - 0.000003583 49.0
TLS2_k127_3088268_2 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 469.0
TLS2_k127_3088268_3 PFAM FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 414.0
TLS2_k127_3088268_4 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 351.0
TLS2_k127_3088268_5 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001039 272.0
TLS2_k127_3088268_6 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000004548 243.0
TLS2_k127_3088268_7 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000002646 235.0
TLS2_k127_3088268_8 XdhC and CoxI family - - - 0.000000000000000000000000000000000000000009418 158.0
TLS2_k127_3088268_9 ETC complex I subunit conserved region - - - 0.0000000000000000000000000003016 118.0
TLS2_k127_3137333_0 Gamma-glutamyltranspeptidase - - - 3.379e-197 632.0
TLS2_k127_3137333_1 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 419.0
TLS2_k127_3137333_10 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000001562 206.0
TLS2_k127_3137333_11 ABC-type tungstate transport system, periplasmic component K05773 - - 0.000000000000000000000000000000000000000000000001672 176.0
TLS2_k127_3137333_12 Protein of unknown function (DUF971) - - - 0.000000000000000000000000000000000000000003844 172.0
TLS2_k127_3137333_13 COG2346, Truncated hemoglobins K03406,K06886 GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057 - 0.00000000000000000000000000000000000003266 149.0
TLS2_k127_3137333_14 Trm112p-like protein K09791 - - 0.00000000000000000000000368 102.0
TLS2_k127_3137333_15 Aminoacyl-tRNA editing domain K19055 - - 0.00000000001399 64.0
TLS2_k127_3137333_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 395.0
TLS2_k127_3137333_3 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 389.0
TLS2_k127_3137333_4 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 358.0
TLS2_k127_3137333_5 Thioredoxin K05838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009444 334.0
TLS2_k127_3137333_6 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002656 271.0
TLS2_k127_3137333_7 AAA domain, putative AbiEii toxin, Type IV TA system K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000003749 257.0
TLS2_k127_3137333_8 COG1335 Amidases related to nicotinamidase - - - 0.000000000000000000000000000000000000000000000000000000000000000007533 230.0
TLS2_k127_3137333_9 to the N-terminal domain of Lon protease K01338,K07157 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000002028 227.0
TLS2_k127_3163108_0 malic enzyme K00029 - 1.1.1.40 0.0 1127.0
TLS2_k127_3163108_1 This protein is involved in the repair of mismatches in DNA K03555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 373.0
TLS2_k127_3165159_0 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 466.0
TLS2_k127_3165159_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 357.0
TLS2_k127_3165159_2 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002297 285.0
TLS2_k127_3165159_3 - - - - 0.000000000009018 71.0
TLS2_k127_3165159_4 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00001187 53.0
TLS2_k127_3179312_0 TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family - - - 3.728e-268 842.0
TLS2_k127_3179312_1 Cytochrome C and Quinol oxidase polypeptide I K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 4.675e-257 822.0
TLS2_k127_3179312_10 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000003814 140.0
TLS2_k127_3179312_11 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000007663 144.0
TLS2_k127_3179312_12 Cytochrome c K00406,K16255 - - 0.0000000000000000000000000000001381 132.0
TLS2_k127_3179312_13 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000002735 115.0
TLS2_k127_3179312_14 cytochrome - - - 0.000000000000000000001456 97.0
TLS2_k127_3179312_15 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000001475 94.0
TLS2_k127_3179312_16 - - - - 0.00000000004552 66.0
TLS2_k127_3179312_17 PAS domain - - - 0.0000000001348 68.0
TLS2_k127_3179312_18 - - - - 0.0000008307 63.0
TLS2_k127_3179312_2 MlrC C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 596.0
TLS2_k127_3179312_3 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000794 496.0
TLS2_k127_3179312_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 435.0
TLS2_k127_3179312_5 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 430.0
TLS2_k127_3179312_6 Bacterial extracellular solute-binding proteins, family 3 K16254 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 332.0
TLS2_k127_3179312_7 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002924 284.0
TLS2_k127_3179312_8 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000000000000000004615 231.0
TLS2_k127_3179312_9 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.00000000000000000000000000000000000000000000000000000000003313 214.0
TLS2_k127_3200976_0 ABC transporter transmembrane region K02021 - - 3.483e-303 953.0
TLS2_k127_3200976_1 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 552.0
TLS2_k127_3200976_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 530.0
TLS2_k127_3200976_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 312.0
TLS2_k127_3200976_4 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 303.0
TLS2_k127_3200976_5 cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000000000000001096 196.0
TLS2_k127_3200976_6 S-adenosyl-L-methionine methyltransferase - - - 0.000000000000000000000000000000000000000000000000003466 189.0
TLS2_k127_3200976_7 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000000000005391 192.0
TLS2_k127_3200976_8 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000002789 151.0
TLS2_k127_3222890_0 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483,K21726 - 1.14.13.166,1.14.13.29,1.14.14.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 570.0
TLS2_k127_3222890_1 PFAM aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 438.0
TLS2_k127_3222890_2 SMP-30/Gluconolaconase/LRE-like region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 385.0
TLS2_k127_3222890_3 short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 332.0
TLS2_k127_3222890_4 PFAM multi antimicrobial extrusion protein MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001013 252.0
TLS2_k127_3222890_5 COG0262 Dihydrofolate reductase - - - 0.000000000000000000000000000000000000000003371 161.0
TLS2_k127_329227_0 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 1.601e-219 703.0
TLS2_k127_329227_1 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 1.033e-206 656.0
TLS2_k127_329227_10 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007986 248.0
TLS2_k127_329227_11 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000001711 211.0
TLS2_k127_329227_12 Protein of unknown function (DUF3225) - - - 0.000000000000000000000000000000000000000000008079 165.0
TLS2_k127_329227_13 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000003882 123.0
TLS2_k127_329227_14 Cupin domain - - - 0.00000000000001579 78.0
TLS2_k127_329227_2 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 587.0
TLS2_k127_329227_3 Belongs to the DEAD box helicase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 559.0
TLS2_k127_329227_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 525.0
TLS2_k127_329227_5 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 511.0
TLS2_k127_329227_6 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 355.0
TLS2_k127_329227_7 Extradiol ring-cleavage dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 313.0
TLS2_k127_329227_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008259 302.0
TLS2_k127_329227_9 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001546 269.0
TLS2_k127_3331728_0 Aerotolerance regulator N-terminal - - - 7.378e-287 912.0
TLS2_k127_3331728_1 membrane - - - 2.187e-256 808.0
TLS2_k127_3331728_10 poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 373.0
TLS2_k127_3331728_11 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006752 334.0
TLS2_k127_3331728_12 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 339.0
TLS2_k127_3331728_13 Cytochrome C1 family K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001779 299.0
TLS2_k127_3331728_14 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004056 274.0
TLS2_k127_3331728_15 Predicted membrane protein (DUF2243) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007137 279.0
TLS2_k127_3331728_16 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.10.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000006219 254.0
TLS2_k127_3331728_17 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000007242 258.0
TLS2_k127_3331728_18 protein conserved in bacteria K09986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008055 245.0
TLS2_k127_3331728_19 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000005421 232.0
TLS2_k127_3331728_2 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 9.912e-197 623.0
TLS2_k127_3331728_20 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001593 229.0
TLS2_k127_3331728_21 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000003748 208.0
TLS2_k127_3331728_22 COG1309 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000003116 174.0
TLS2_k127_3331728_23 oxidation-reduction process - - - 0.0000000000000000000000000000000000000001148 154.0
TLS2_k127_3331728_24 Transcriptional regulator - - - 0.000000000000000000000000000000000000005461 155.0
TLS2_k127_3331728_25 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000002567 145.0
TLS2_k127_3331728_26 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000001564 142.0
TLS2_k127_3331728_27 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000709 117.0
TLS2_k127_3331728_28 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000002247 107.0
TLS2_k127_3331728_29 - - - - 0.000000002154 68.0
TLS2_k127_3331728_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 504.0
TLS2_k127_3331728_30 - - - - 0.00000001221 67.0
TLS2_k127_3331728_4 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 517.0
TLS2_k127_3331728_5 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 - 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 473.0
TLS2_k127_3331728_6 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 448.0
TLS2_k127_3331728_7 lactate metabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 450.0
TLS2_k127_3331728_8 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 437.0
TLS2_k127_3331728_9 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006303 381.0
TLS2_k127_3391958_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 1.638e-224 703.0
TLS2_k127_3391958_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 2.859e-196 635.0
TLS2_k127_3391958_2 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000008177 230.0
TLS2_k127_3391958_3 metal-binding protein - - - 0.000000000000000000000000000000000000000000000001067 182.0
TLS2_k127_3391958_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000284 66.0
TLS2_k127_3391958_6 Sulfite exporter TauE/SafE K07090 - - 0.0003166 44.0
TLS2_k127_3400745_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 467.0
TLS2_k127_3400745_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 419.0
TLS2_k127_3400745_2 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 340.0
TLS2_k127_3400745_3 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006928 305.0
TLS2_k127_3400745_4 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 317.0
TLS2_k127_3400745_5 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000002079 200.0
TLS2_k127_3400745_6 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.00000000000000000009736 101.0
TLS2_k127_3400745_7 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000006363 81.0
TLS2_k127_3400745_8 Sulfatase-modifying factor enzyme 1 - - - 0.0000001988 64.0
TLS2_k127_3400745_9 Psort location Extracellular, score K07126 - - 0.00001984 53.0
TLS2_k127_3409263_0 COG0643 Chemotaxis protein histidine kinase and related kinases K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 402.0
TLS2_k127_3409263_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 317.0
TLS2_k127_3409263_2 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000000000000000006574 171.0
TLS2_k127_3409263_3 Respiratory-chain NADH dehydrogenase 51 Kd subunit K00122,K00124,K00335 - 1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000003204 161.0
TLS2_k127_3409263_4 signal transduction histidine kinase K13588 - - 0.00000000000000000000000000000000005528 154.0
TLS2_k127_3409263_5 Protein of unknown function (DUF3553) - - - 0.000000000000001895 78.0
TLS2_k127_3409263_6 - - - - 0.0000006119 60.0
TLS2_k127_3411519_0 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 495.0
TLS2_k127_3411519_1 Terminase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 345.0
TLS2_k127_3411519_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 337.0
TLS2_k127_3411519_3 Family of unknown function (DUF5309) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 329.0
TLS2_k127_3411519_5 Terminase RNaseH-like domain - - - 0.0000000000000000000000000000000000000000000000000003795 203.0
TLS2_k127_3411519_6 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000004442 132.0
TLS2_k127_3411519_7 - - - - 0.000002083 59.0
TLS2_k127_3417044_0 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 1.846e-318 994.0
TLS2_k127_3417044_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300,K08301 - 3.1.26.12 5.959e-219 706.0
TLS2_k127_3417044_10 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 371.0
TLS2_k127_3417044_11 Protein of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007299 384.0
TLS2_k127_3417044_12 Sir2 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 349.0
TLS2_k127_3417044_13 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 343.0
TLS2_k127_3417044_14 hydrolase of the alpha beta superfamily K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 330.0
TLS2_k127_3417044_15 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 329.0
TLS2_k127_3417044_16 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009948 333.0
TLS2_k127_3417044_17 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 322.0
TLS2_k127_3417044_18 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 302.0
TLS2_k127_3417044_19 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004258 287.0
TLS2_k127_3417044_2 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 7.028e-195 623.0
TLS2_k127_3417044_20 serine acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000301 269.0
TLS2_k127_3417044_21 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004449 267.0
TLS2_k127_3417044_22 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008108 262.0
TLS2_k127_3417044_23 COG2199 FOG GGDEF domain K13590 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000002336 270.0
TLS2_k127_3417044_24 Domain of unknown function (DUF1932) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005334 258.0
TLS2_k127_3417044_25 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000006379 245.0
TLS2_k127_3417044_26 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000005655 229.0
TLS2_k127_3417044_27 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000003112 226.0
TLS2_k127_3417044_28 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000000000007822 208.0
TLS2_k127_3417044_29 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000004148 197.0
TLS2_k127_3417044_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008778 579.0
TLS2_k127_3417044_30 transcriptional regulator K13643 - - 0.000000000000000000000000000000000000000000005098 175.0
TLS2_k127_3417044_31 Ferredoxin K04755 - - 0.000000000000000000000000000000000000004447 148.0
TLS2_k127_3417044_32 COG1664 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000001647 134.0
TLS2_k127_3417044_33 Phosphoesterase K19803 - 2.7.4.29 0.00000000000000000000000000000002564 138.0
TLS2_k127_3417044_34 - - - - 0.0000000000000000000000000000004308 136.0
TLS2_k127_3417044_35 TfoX N-terminal domain K07343 - - 0.00000000000000000000000002236 112.0
TLS2_k127_3417044_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 503.0
TLS2_k127_3417044_5 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 462.0
TLS2_k127_3417044_6 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 438.0
TLS2_k127_3417044_7 Zn-dependent protease, contains TPR repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 427.0
TLS2_k127_3417044_8 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008227 403.0
TLS2_k127_3417044_9 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 392.0
TLS2_k127_3420753_0 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008813 450.0
TLS2_k127_3420753_1 Response regulator receiver K03413 - - 0.00000000000000000000000000000000000000000000000000000000001277 212.0
TLS2_k127_3420753_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000001952 217.0
TLS2_k127_3420753_3 COG2030 Acyl dehydratase K17865 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016043,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0042620,GO:0042621,GO:0043933,GO:0044085,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576 4.2.1.55 0.00000000000000000000000000000000000000000000000000006612 192.0
TLS2_k127_3420753_4 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity - - - 0.0000000000000000000000000000000000000000000001387 179.0
TLS2_k127_3443984_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 2.629e-309 962.0
TLS2_k127_3443984_1 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 605.0
TLS2_k127_3443984_10 - - - - 0.0001133 50.0
TLS2_k127_3443984_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008138 580.0
TLS2_k127_3443984_3 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006224 589.0
TLS2_k127_3443984_4 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 476.0
TLS2_k127_3443984_5 X-Pro dipeptidyl-peptidase (S15 family) K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 439.0
TLS2_k127_3443984_6 Succinate dehydrogenase Fumarate reductase K00241 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000003021 173.0
TLS2_k127_3443984_7 Domain of unknown function (DUF4154) - - - 0.00000000000000000000000000000000000000008492 157.0
TLS2_k127_3443984_8 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.00000000000000000000000000000000042 135.0
TLS2_k127_3443984_9 Sel1-like repeats. - - - 0.00000000000000000000007969 106.0
TLS2_k127_3452900_0 Sodium/hydrogen exchanger family K03316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007305 591.0
TLS2_k127_3452900_1 COG0659 Sulfate permease and related transporters (MFS superfamily) K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 555.0
TLS2_k127_3452900_10 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.0000000000000000000000000000000000000000000000000000004671 198.0
TLS2_k127_3452900_11 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000003467 169.0
TLS2_k127_3452900_12 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000007001 157.0
TLS2_k127_3452900_13 Transcription elongation factor K06140 - - 0.000000000000000000000000000000000000002552 151.0
TLS2_k127_3452900_14 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.0000000000000000000000000000000005432 149.0
TLS2_k127_3452900_15 OstA-like protein K09774 - - 0.00000000000000000000000000000002608 141.0
TLS2_k127_3452900_16 Immunity protein 8 - - - 0.00000000000001024 78.0
TLS2_k127_3452900_17 Protein of unknown function (DUF1150) - - - 0.000000000006914 69.0
TLS2_k127_3452900_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 548.0
TLS2_k127_3452900_3 ABC transporter, ATP-binding protein K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007302 409.0
TLS2_k127_3452900_4 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004258 377.0
TLS2_k127_3452900_5 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 334.0
TLS2_k127_3452900_6 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 307.0
TLS2_k127_3452900_7 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004533 273.0
TLS2_k127_3452900_8 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.000000000000000000000000000000000000000000000000000000000000002732 226.0
TLS2_k127_3452900_9 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000000000000000000000005222 207.0
TLS2_k127_3477_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 601.0
TLS2_k127_3477_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 408.0
TLS2_k127_3477_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 360.0
TLS2_k127_3477_3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000001777 235.0
TLS2_k127_3477_4 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000177 206.0
TLS2_k127_3477_5 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000001098 201.0
TLS2_k127_3477_6 SMART helix-turn-helix domain protein K18831 - - 0.000000000000000000000000000000000000000000003145 167.0
TLS2_k127_3477_7 protein conserved in bacteria K19166 - - 0.000000000000000000000000000001434 123.0
TLS2_k127_3477_8 - - - - 0.0000000011 59.0
TLS2_k127_3477_9 - - - - 0.00003943 55.0
TLS2_k127_349060_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 516.0
TLS2_k127_349060_1 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 481.0
TLS2_k127_349060_10 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001673 267.0
TLS2_k127_349060_11 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000009679 232.0
TLS2_k127_349060_12 Sterol carrier protein - - - 0.000000000000000000000000000000000000000000000006519 177.0
TLS2_k127_349060_13 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000001314 182.0
TLS2_k127_349060_14 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000002165 178.0
TLS2_k127_349060_15 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000007627 136.0
TLS2_k127_349060_16 - - - - 0.0000000000000000008978 89.0
TLS2_k127_349060_2 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 518.0
TLS2_k127_349060_3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 409.0
TLS2_k127_349060_4 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 406.0
TLS2_k127_349060_5 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 397.0
TLS2_k127_349060_6 AMP-binding enzyme C-terminal domain K00666,K01897,K16876 - 6.2.1.3,6.2.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 410.0
TLS2_k127_349060_7 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005736 380.0
TLS2_k127_349060_8 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 363.0
TLS2_k127_349060_9 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 313.0
TLS2_k127_3533226_0 Uncharacterized protein family (UPF0051) K09014 - - 2.78e-270 840.0
TLS2_k127_3533226_1 Glycosyl hydrolases family 15 - - - 1.772e-249 783.0
TLS2_k127_3533226_10 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000000000000000000000003715 214.0
TLS2_k127_3533226_11 Glucokinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000001236 211.0
TLS2_k127_3533226_12 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000000000000000000000002407 177.0
TLS2_k127_3533226_13 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000000000001451 159.0
TLS2_k127_3533226_14 Transcriptional regulator - - - 0.00000000000000000000000000000000000000001246 158.0
TLS2_k127_3533226_15 Iron-sulfur cluster assembly protein - - - 0.000000000000000000000000000000000000004095 157.0
TLS2_k127_3533226_2 Hydantoinase/oxoprolinase N-terminal region - - - 1.088e-230 723.0
TLS2_k127_3533226_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 548.0
TLS2_k127_3533226_4 Glycosyltransferase family 20 K16055 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034637,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044464,GO:0046351,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:1901576 2.4.1.15,3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 563.0
TLS2_k127_3533226_5 L-lactate permease K03303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 479.0
TLS2_k127_3533226_6 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 483.0
TLS2_k127_3533226_7 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 396.0
TLS2_k127_3533226_8 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 354.0
TLS2_k127_3533226_9 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000004759 222.0
TLS2_k127_3541305_0 BFD domain protein 2Fe-2S -binding domain protein K00372,K02567 - - 0.0 1483.0
TLS2_k127_3541305_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520,K04108 - 1.2.5.3,1.3.7.9 1.16e-302 955.0
TLS2_k127_3541305_10 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB K02568 - - 0.000000000000000000000000000000000000000000000000000000005721 209.0
TLS2_k127_3541305_11 ferredoxin-type protein NapF K02572 - - 0.000000000000000000000000000000000000000000000000001518 191.0
TLS2_k127_3541305_12 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000000008477 187.0
TLS2_k127_3541305_13 Periplasmic or secreted lipoprotein - - - 0.00000000000000000000000000000000000000000000006295 175.0
TLS2_k127_3541305_14 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 0.000000000000000000000000000000000000000004182 160.0
TLS2_k127_3541305_15 Nitrate reductase K02571 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000001407 83.0
TLS2_k127_3541305_16 - - - - 0.000000000000006439 76.0
TLS2_k127_3541305_17 Ceramidase - - - 0.00000000000001334 76.0
TLS2_k127_3541305_18 NapD protein K02570 - - 0.00000000000008845 77.0
TLS2_k127_3541305_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 594.0
TLS2_k127_3541305_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 435.0
TLS2_k127_3541305_4 Cytochrome c-type protein K02569 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 392.0
TLS2_k127_3541305_5 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004703 359.0
TLS2_k127_3541305_6 CO dehydrogenase flavoprotein C-terminal domain K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 324.0
TLS2_k127_3541305_7 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001326 266.0
TLS2_k127_3541305_8 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001998 266.0
TLS2_k127_3541305_9 [2Fe-2S] binding domain K04107 - 1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000162 215.0
TLS2_k127_3549061_0 DNA helicase K03657 - 3.6.4.12 3.175e-320 999.0
TLS2_k127_3549061_1 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 3.14e-264 835.0
TLS2_k127_3549061_10 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009372 389.0
TLS2_k127_3549061_11 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 380.0
TLS2_k127_3549061_12 amino acid K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 349.0
TLS2_k127_3549061_13 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 343.0
TLS2_k127_3549061_14 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000223 185.0
TLS2_k127_3549061_15 Thioesterase-like superfamily - - - 0.00000000000000000000000000000000000000000000001337 181.0
TLS2_k127_3549061_16 Stringent starvation protein B K09985 - - 0.00000000000000000000000000000000000000001063 171.0
TLS2_k127_3549061_17 ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000000000316 166.0
TLS2_k127_3549061_18 Ribbon-helix-helix domain - - - 0.0000000000000000002382 89.0
TLS2_k127_3549061_19 Pentapeptide repeats (9 copies) - - - 0.000000000006492 76.0
TLS2_k127_3549061_2 TRAP transporter, 4TM 12TM fusion protein - - - 4.734e-218 694.0
TLS2_k127_3549061_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.455e-214 728.0
TLS2_k127_3549061_4 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 1.79e-208 657.0
TLS2_k127_3549061_5 AsmA family K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 623.0
TLS2_k127_3549061_6 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 545.0
TLS2_k127_3549061_7 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 536.0
TLS2_k127_3549061_8 Chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 551.0
TLS2_k127_3549061_9 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 412.0
TLS2_k127_3558519_0 GMC oxidoreductase K00108 - 1.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 606.0
TLS2_k127_3558519_1 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 435.0
TLS2_k127_3558519_2 LexA-binding, inner membrane-associated putative hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 336.0
TLS2_k127_3558519_3 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004708 278.0
TLS2_k127_3558519_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008401 259.0
TLS2_k127_3558519_5 Disulphide bond corrector protein DsbC K04084,K08344 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000001516 261.0
TLS2_k127_356347_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 9.738e-245 784.0
TLS2_k127_356347_1 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 2.142e-199 644.0
TLS2_k127_356347_10 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 421.0
TLS2_k127_356347_11 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 433.0
TLS2_k127_356347_12 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 438.0
TLS2_k127_356347_13 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008694 424.0
TLS2_k127_356347_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 411.0
TLS2_k127_356347_15 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 389.0
TLS2_k127_356347_16 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 361.0
TLS2_k127_356347_17 Branched-chain amino acid ATP-binding cassette transporter K01995,K11962 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007369 349.0
TLS2_k127_356347_18 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 323.0
TLS2_k127_356347_19 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 293.0
TLS2_k127_356347_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000615 601.0
TLS2_k127_356347_20 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000143 282.0
TLS2_k127_356347_21 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001744 284.0
TLS2_k127_356347_22 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001408 287.0
TLS2_k127_356347_23 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000167 268.0
TLS2_k127_356347_24 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000002854 244.0
TLS2_k127_356347_25 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000004155 213.0
TLS2_k127_356347_26 HupE / UreJ protein K03192 - - 0.0000000000000000000000000000000000000000000000000000000003204 224.0
TLS2_k127_356347_27 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000000004888 200.0
TLS2_k127_356347_28 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000002053 192.0
TLS2_k127_356347_29 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000001456 181.0
TLS2_k127_356347_3 Periplasmic binding protein domain K11959 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 578.0
TLS2_k127_356347_30 Protein of unknown function (DUF1194) - - - 0.000000000000000000000000000000000000000000006249 184.0
TLS2_k127_356347_31 - - - - 0.0000000000000000000000000000001704 125.0
TLS2_k127_356347_32 Thioesterase superfamily - - - 0.0000000000000000000000001341 112.0
TLS2_k127_356347_33 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000753 108.0
TLS2_k127_356347_34 oxidation-reduction process K04782 - 4.2.99.21 0.00000000000001436 86.0
TLS2_k127_356347_4 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009752 501.0
TLS2_k127_356347_5 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 484.0
TLS2_k127_356347_6 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000581 480.0
TLS2_k127_356347_7 Oligopeptide/dipeptide transporter, C-terminal region K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 474.0
TLS2_k127_356347_8 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 460.0
TLS2_k127_356347_9 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 439.0
TLS2_k127_3568742_0 COG4664 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 1.025e-212 678.0
TLS2_k127_3568742_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K10617 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008298 330.0
TLS2_k127_3568742_2 Enoyl-CoA hydratase/isomerase K15312 - - 0.000000000000000000000000000000000000000000000000000000000000000000003753 243.0
TLS2_k127_3568742_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000000191 209.0
TLS2_k127_3568742_4 CBS domain - - - 0.00000000000000000000000000000000001383 141.0
TLS2_k127_3568742_5 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000432 96.0
TLS2_k127_3568742_6 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.000000001017 70.0
TLS2_k127_3574038_0 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 7.907e-308 980.0
TLS2_k127_3574038_1 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 9.217e-281 894.0
TLS2_k127_3574038_10 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000008017 176.0
TLS2_k127_3574038_11 - - - - 0.0000000000000000000000000000000000000000000001824 170.0
TLS2_k127_3574038_12 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000001312 162.0
TLS2_k127_3574038_13 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000000000002346 151.0
TLS2_k127_3574038_14 - - - - 0.0000000000000000003987 88.0
TLS2_k127_3574038_15 - - - - 0.00000001026 57.0
TLS2_k127_3574038_16 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - - 0.000002368 59.0
TLS2_k127_3574038_2 AMP-binding enzyme C-terminal domain K04116 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 448.0
TLS2_k127_3574038_3 AMP-binding enzyme C-terminal domain K00666,K16876 - 6.2.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 350.0
TLS2_k127_3574038_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002389 280.0
TLS2_k127_3574038_5 Aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001191 259.0
TLS2_k127_3574038_6 Nucleotidyl transferase K00966,K00992 - 2.7.7.13,2.7.7.99 0.000000000000000000000000000000000000000000000000000000000000000000000009 265.0
TLS2_k127_3574038_7 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000002117 244.0
TLS2_k127_3574038_8 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000000005681 218.0
TLS2_k127_3574038_9 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000003314 219.0
TLS2_k127_378076_0 L-lysine 6-monooxygenase (NADPH-requiring) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 480.0
TLS2_k127_378076_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 470.0
TLS2_k127_378076_10 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000000005233 185.0
TLS2_k127_378076_11 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000003018 181.0
TLS2_k127_378076_12 Protein of unknown function (DUF1194) - - - 0.00000000000000000000000000000000000000000007062 183.0
TLS2_k127_378076_13 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000003914 159.0
TLS2_k127_378076_14 Haemolysin-III related K11068 - - 0.00000000000000000000000000007318 118.0
TLS2_k127_378076_15 - - - - 0.000000000000000139 83.0
TLS2_k127_378076_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 443.0
TLS2_k127_378076_3 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 357.0
TLS2_k127_378076_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 308.0
TLS2_k127_378076_5 metal-dependent hydrolase of the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003698 274.0
TLS2_k127_378076_6 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.0000000000000000000000000000000000000000000000000000000000000000000003765 248.0
TLS2_k127_378076_7 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000001624 230.0
TLS2_k127_378076_8 KDPG and KHG aldolase K01631 - 4.1.2.21 0.0000000000000000000000000000000000000000000000000000000000006943 216.0
TLS2_k127_378076_9 flavin adenine dinucleotide binding - - - 0.00000000000000000000000000000000000000000000000000003194 200.0
TLS2_k127_3807502_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0 1076.0
TLS2_k127_3807502_1 COG0513 Superfamily II DNA and RNA helicases K17675 - 3.6.4.13 4.41e-271 857.0
TLS2_k127_3807502_10 Belongs to the 5'-nucleotidase family K01081,K11751 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006213,GO:0006259,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007155,GO:0007159,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009164,GO:0009166,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019362,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0022610,GO:0031974,GO:0031981,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046135,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0072524,GO:0072527,GO:0072529,GO:0090304,GO:0098609,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 445.0
TLS2_k127_3807502_11 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 416.0
TLS2_k127_3807502_12 Belongs to the mandelate racemase muconate lactonizing enzyme family K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 411.0
TLS2_k127_3807502_13 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 391.0
TLS2_k127_3807502_14 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 398.0
TLS2_k127_3807502_15 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 387.0
TLS2_k127_3807502_16 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 389.0
TLS2_k127_3807502_17 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006709 379.0
TLS2_k127_3807502_18 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 376.0
TLS2_k127_3807502_19 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 377.0
TLS2_k127_3807502_2 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 5.427e-266 836.0
TLS2_k127_3807502_20 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 377.0
TLS2_k127_3807502_21 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 357.0
TLS2_k127_3807502_22 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 350.0
TLS2_k127_3807502_23 DnaJ C terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 311.0
TLS2_k127_3807502_24 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 306.0
TLS2_k127_3807502_25 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K07313 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 293.0
TLS2_k127_3807502_26 taurine catabolism dioxygenase K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005259 301.0
TLS2_k127_3807502_27 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000373 284.0
TLS2_k127_3807502_28 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009797 256.0
TLS2_k127_3807502_29 Staphylococcal nuclease homologue - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002302 250.0
TLS2_k127_3807502_3 AMP-binding enzyme C-terminal domain K00666,K02182,K20034 - 6.2.1.44,6.2.1.48 3.13e-253 791.0
TLS2_k127_3807502_30 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000004578 252.0
TLS2_k127_3807502_31 transcriptional regulator K07736 - - 0.00000000000000000000000000000000000000000000000000000000000000001318 228.0
TLS2_k127_3807502_32 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002468 235.0
TLS2_k127_3807502_33 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000007209 220.0
TLS2_k127_3807502_34 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000000521 203.0
TLS2_k127_3807502_35 Esterase-like activity of phytase - - - 0.0000000000000000000000000000000000000000000000000000001421 207.0
TLS2_k127_3807502_36 17 kDa outer membrane surface antigen - - - 0.0000000000000000000000000000000000000000000000000000006132 198.0
TLS2_k127_3807502_37 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000003658 201.0
TLS2_k127_3807502_38 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000001559 189.0
TLS2_k127_3807502_39 PAC2 family - - - 0.000000000000000000000000000000000000000000000000002242 191.0
TLS2_k127_3807502_4 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations K01241 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008714,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464 3.2.2.4 3.484e-247 774.0
TLS2_k127_3807502_40 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000004612 198.0
TLS2_k127_3807502_41 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000004457 179.0
TLS2_k127_3807502_42 Dehydroquinase class II - - - 0.00000000000000000000000000000000000000000004915 167.0
TLS2_k127_3807502_43 domain, Protein K20276 - - 0.00000000000000000000000000000000000000001034 179.0
TLS2_k127_3807502_44 transduction histidine kinase - - - 0.00000000000000000000000000000000000000001209 173.0
TLS2_k127_3807502_45 FecR protein - - - 0.000000000000000000000000000000000002267 160.0
TLS2_k127_3807502_46 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000003066 145.0
TLS2_k127_3807502_47 SnoaL-like domain - - - 0.000000000000000000000000000000003459 139.0
TLS2_k127_3807502_48 Tellurite resistance protein TerB - - - 0.000000000000000000000000000000005934 145.0
TLS2_k127_3807502_49 FecR protein - - - 0.00000000000000000000000000000006868 146.0
TLS2_k127_3807502_5 Aminotransferase class-III K16871 - 2.6.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 598.0
TLS2_k127_3807502_50 Crea protein K05805 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000009749 123.0
TLS2_k127_3807502_51 PFAM Sel1 domain protein repeat-containing protein K07126,K13582 - - 0.000000000000000000000000000005223 136.0
TLS2_k127_3807502_52 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000001038 124.0
TLS2_k127_3807502_54 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000001666 116.0
TLS2_k127_3807502_55 S4 RNA-binding domain K04762 - - 0.00000000000000000000003179 109.0
TLS2_k127_3807502_56 - - - - 0.00000000000000004331 86.0
TLS2_k127_3807502_6 Alanine-glyoxylate amino-transferase K00375,K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 561.0
TLS2_k127_3807502_7 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 548.0
TLS2_k127_3807502_8 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 427.0
TLS2_k127_3807502_9 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 421.0
TLS2_k127_3830383_0 Domain of unknown function (DUF3459) K00700 - 2.4.1.18 0.0 1019.0
TLS2_k127_3830383_1 Thiamine pyrophosphate enzyme, central domain K00156 - 1.2.5.1 7.271e-288 902.0
TLS2_k127_3830383_10 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000000000000000000000000000000003707 223.0
TLS2_k127_3830383_11 Carboxylesterase family K01432 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000005598 207.0
TLS2_k127_3830383_12 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000000000868 170.0
TLS2_k127_3830383_13 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000001205 150.0
TLS2_k127_3830383_14 Glycoside hydrolase - - - 0.000000000000000000000000000001021 130.0
TLS2_k127_3830383_2 COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 8.924e-209 657.0
TLS2_k127_3830383_3 PFAM AMP-dependent synthetase and ligase - - - 1.609e-207 659.0
TLS2_k127_3830383_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005861 450.0
TLS2_k127_3830383_5 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 404.0
TLS2_k127_3830383_6 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 400.0
TLS2_k127_3830383_7 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 354.0
TLS2_k127_3830383_8 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005512 323.0
TLS2_k127_3830383_9 O-Antigen ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001743 263.0
TLS2_k127_3853582_0 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 585.0
TLS2_k127_3853582_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 561.0
TLS2_k127_3853582_10 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000008782 237.0
TLS2_k127_3853582_11 protein affecting Mg2 Co2 transport K06195 - - 0.0000000000000000000000000000000000000000000000006192 188.0
TLS2_k127_3853582_12 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000001169 184.0
TLS2_k127_3853582_13 - - - - 0.0000000000000000000000000000000009151 138.0
TLS2_k127_3853582_14 - - - - 0.000000000000000003455 99.0
TLS2_k127_3853582_15 - - - - 0.0000003626 54.0
TLS2_k127_3853582_16 - - - - 0.0004795 46.0
TLS2_k127_3853582_2 DNA photolyase K01669 GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 542.0
TLS2_k127_3853582_3 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 523.0
TLS2_k127_3853582_4 Aminotransferase class-III K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 505.0
TLS2_k127_3853582_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000619 479.0
TLS2_k127_3853582_6 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 435.0
TLS2_k127_3853582_7 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008897 401.0
TLS2_k127_3853582_8 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009579 305.0
TLS2_k127_3853582_9 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000021 236.0
TLS2_k127_3862338_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 609.0
TLS2_k127_3862338_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 552.0
TLS2_k127_3862338_10 Preprotein translocase subunit YajC K03210 - - 0.000000000000000000000000000000000000000001897 159.0
TLS2_k127_3862338_11 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000000000001235 149.0
TLS2_k127_3862338_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000858 108.0
TLS2_k127_3862338_13 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000002117 109.0
TLS2_k127_3862338_14 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000007884 102.0
TLS2_k127_3862338_15 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0003674,GO:0005215 - 0.00000000000000005979 84.0
TLS2_k127_3862338_16 positive regulation of growth - - - 0.000000003315 61.0
TLS2_k127_3862338_2 Protein of unknown function (DUF815) K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 415.0
TLS2_k127_3862338_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006642 351.0
TLS2_k127_3862338_4 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 325.0
TLS2_k127_3862338_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 308.0
TLS2_k127_3862338_6 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 309.0
TLS2_k127_3862338_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 300.0
TLS2_k127_3862338_8 Lysin motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009637 266.0
TLS2_k127_3862338_9 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000811 266.0
TLS2_k127_3880766_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 543.0
TLS2_k127_3880766_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 488.0
TLS2_k127_3880766_2 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 351.0
TLS2_k127_3880766_3 carbonic anhydrase K01674 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000003604 220.0
TLS2_k127_3880766_4 Cell division protein FtsQ K03589 - - 0.00000000000000001931 83.0
TLS2_k127_3882496_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 7.139e-247 776.0
TLS2_k127_3882496_1 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001264 252.0
TLS2_k127_3882496_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000001088 186.0
TLS2_k127_3882496_3 Protein of unknown function (DUF433) - - - 0.0000000000000000000000000000000000000000000009965 176.0
TLS2_k127_3882496_4 AMP-binding enzyme - - - 0.0000000000000000000000000007666 115.0
TLS2_k127_3882496_5 phosphohistidine phosphatase, SixA - - - 0.00000000000000000005184 94.0
TLS2_k127_3882496_6 ABC-type transport auxiliary lipoprotein component - - - 0.000000000000001575 88.0
TLS2_k127_3882496_7 - - - - 0.00008383 51.0
TLS2_k127_3899631_0 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 567.0
TLS2_k127_3899631_1 Methionine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 501.0
TLS2_k127_3899631_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000002297 218.0
TLS2_k127_3977159_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 4.923e-313 979.0
TLS2_k127_3977159_1 KR domain K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004329 276.0
TLS2_k127_3977159_2 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000003963 156.0
TLS2_k127_4025798_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1334.0
TLS2_k127_4025798_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1304.0
TLS2_k127_4025798_10 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 442.0
TLS2_k127_4025798_11 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816 - 3.6.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006671 452.0
TLS2_k127_4025798_12 Binding-protein-dependent transport system inner membrane component K05814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 431.0
TLS2_k127_4025798_13 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 430.0
TLS2_k127_4025798_14 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 419.0
TLS2_k127_4025798_15 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 410.0
TLS2_k127_4025798_16 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 394.0
TLS2_k127_4025798_17 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 353.0
TLS2_k127_4025798_18 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 337.0
TLS2_k127_4025798_19 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 329.0
TLS2_k127_4025798_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1191.0
TLS2_k127_4025798_20 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 322.0
TLS2_k127_4025798_21 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 332.0
TLS2_k127_4025798_22 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 308.0
TLS2_k127_4025798_23 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001108 287.0
TLS2_k127_4025798_24 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000009298 260.0
TLS2_k127_4025798_25 flagellar motor protein K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004022 270.0
TLS2_k127_4025798_26 COG2518 Protein-L-isoaspartate carboxylmethyltransferase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000005034 249.0
TLS2_k127_4025798_27 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000004329 228.0
TLS2_k127_4025798_28 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000000000000000000000006232 214.0
TLS2_k127_4025798_29 hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000003944 206.0
TLS2_k127_4025798_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.842e-313 968.0
TLS2_k127_4025798_30 Sugar-transfer associated ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000008738 209.0
TLS2_k127_4025798_31 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000003379 196.0
TLS2_k127_4025798_32 Dioxygenase K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000006755 178.0
TLS2_k127_4025798_33 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000000000000000000000000000008059 172.0
TLS2_k127_4025798_34 Polysaccharide pyruvyl transferase - - - 0.00000000000000000000000000000000000000003841 171.0
TLS2_k127_4025798_35 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000005157 169.0
TLS2_k127_4025798_36 COG0784 FOG CheY-like receiver - - - 0.000000000000000000000000000000000001777 147.0
TLS2_k127_4025798_37 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000005216 144.0
TLS2_k127_4025798_38 protein conserved in bacteria K09991 - - 0.000000000000000000000006824 109.0
TLS2_k127_4025798_39 GtrA-like protein - - - 0.00000000000000002405 87.0
TLS2_k127_4025798_4 GAF domain K01768 - 4.6.1.1 2.131e-210 686.0
TLS2_k127_4025798_40 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000006895 89.0
TLS2_k127_4025798_41 helix_turn_helix, Lux Regulon - - - 0.0000000000001037 85.0
TLS2_k127_4025798_42 - - - - 0.0000000000003191 76.0
TLS2_k127_4025798_43 PFAM Cyclic nucleotide-binding K01420,K21563 - - 0.00000002224 65.0
TLS2_k127_4025798_44 TadE-like protein - - - 0.000002124 57.0
TLS2_k127_4025798_46 TadE-like protein - - - 0.000006088 55.0
TLS2_k127_4025798_48 - - - - 0.00009452 55.0
TLS2_k127_4025798_49 - - - - 0.0002839 53.0
TLS2_k127_4025798_5 Bacterial extracellular solute-binding protein K05813 - - 4.87e-201 633.0
TLS2_k127_4025798_50 - - - - 0.0004382 53.0
TLS2_k127_4025798_6 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 531.0
TLS2_k127_4025798_7 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 526.0
TLS2_k127_4025798_8 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007562 506.0
TLS2_k127_4025798_9 poly(R)-hydroxyalkanoic acid synthase K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 520.0
TLS2_k127_4037055_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.726e-295 918.0
TLS2_k127_4037055_1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 2.353e-274 870.0
TLS2_k127_4037055_10 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 561.0
TLS2_k127_4037055_11 ABC-type oligopeptide transport system, periplasmic component K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 559.0
TLS2_k127_4037055_12 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 544.0
TLS2_k127_4037055_13 COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 548.0
TLS2_k127_4037055_14 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 509.0
TLS2_k127_4037055_15 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 505.0
TLS2_k127_4037055_16 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 495.0
TLS2_k127_4037055_17 CoA-transferase family III K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 496.0
TLS2_k127_4037055_18 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 446.0
TLS2_k127_4037055_19 CoA-transferase family III K14470 - 5.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 430.0
TLS2_k127_4037055_2 GTP-binding protein TypA K06207 - - 6.785e-268 866.0
TLS2_k127_4037055_20 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 420.0
TLS2_k127_4037055_21 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 416.0
TLS2_k127_4037055_22 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007393 414.0
TLS2_k127_4037055_23 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 404.0
TLS2_k127_4037055_24 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 411.0
TLS2_k127_4037055_25 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005745 349.0
TLS2_k127_4037055_26 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 338.0
TLS2_k127_4037055_27 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 341.0
TLS2_k127_4037055_28 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 323.0
TLS2_k127_4037055_29 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 315.0
TLS2_k127_4037055_3 FAD dependent oxidoreductase - - - 3.881e-239 747.0
TLS2_k127_4037055_30 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 303.0
TLS2_k127_4037055_31 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001565 287.0
TLS2_k127_4037055_32 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001086 281.0
TLS2_k127_4037055_33 GDP-mannose 4,6 dehydratase K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002232 282.0
TLS2_k127_4037055_34 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001546 270.0
TLS2_k127_4037055_35 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004421 280.0
TLS2_k127_4037055_36 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002316 254.0
TLS2_k127_4037055_37 PFAM O-methyltransferase, family 3 K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000000007439 239.0
TLS2_k127_4037055_38 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000001878 221.0
TLS2_k127_4037055_39 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000001086 214.0
TLS2_k127_4037055_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 1.091e-218 702.0
TLS2_k127_4037055_40 Dicarboxylate transport - - - 0.0000000000000000000000000000000000000000000000000003656 212.0
TLS2_k127_4037055_41 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.0000000000000000000000000000000000000000000001489 176.0
TLS2_k127_4037055_42 PAS domain - - - 0.00000000000000000000000000000000000000000001507 167.0
TLS2_k127_4037055_43 SnoaL-like domain - - - 0.00000000000000000000000000000000000000002175 156.0
TLS2_k127_4037055_44 - - - - 0.0000000000000000000000000000000000000005386 161.0
TLS2_k127_4037055_45 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.000000000000000000000000000000000000003105 152.0
TLS2_k127_4037055_46 membrane - - - 0.0000000000000000000000000000000009809 134.0
TLS2_k127_4037055_47 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.0000000000000000000000000008647 121.0
TLS2_k127_4037055_48 Transcriptional regulatory protein, C terminal K14981 - - 0.000000000000000000002773 107.0
TLS2_k127_4037055_49 PFAM Rv0623 family protein transcription factor K19687 - - 0.0000000000000000001601 91.0
TLS2_k127_4037055_5 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 6.701e-206 655.0
TLS2_k127_4037055_50 Protein conserved in bacteria K09978 - - 0.000000000000000004231 92.0
TLS2_k127_4037055_51 YnbE-like lipoprotein - - - 0.000000000057 77.0
TLS2_k127_4037055_52 protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis - - - 0.000003484 53.0
TLS2_k127_4037055_53 response regulator - - - 0.00001184 51.0
TLS2_k127_4037055_6 Aminotransferase class-III K01845 - 5.4.3.8 3.766e-205 647.0
TLS2_k127_4037055_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 1.05e-203 643.0
TLS2_k127_4037055_8 C4-dicarboxylate transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 600.0
TLS2_k127_4037055_9 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 574.0
TLS2_k127_4073447_0 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 557.0
TLS2_k127_4073447_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 514.0
TLS2_k127_4073447_10 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.00000000001623 77.0
TLS2_k127_4073447_2 P-aminobenzoate N-oxygenase AurF - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 505.0
TLS2_k127_4073447_3 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 338.0
TLS2_k127_4073447_4 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 329.0
TLS2_k127_4073447_5 COG1560 Lauroyl myristoyl acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000001992 267.0
TLS2_k127_4073447_6 PIN domain - - - 0.00000000000000000000000000000000005075 139.0
TLS2_k127_4073447_7 3-deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000001947 121.0
TLS2_k127_4073447_8 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000009558 96.0
TLS2_k127_4073447_9 Adenylate cyclase - - - 0.00000000000000002559 85.0
TLS2_k127_4077970_0 COG0457 FOG TPR repeat - - - 4.685e-268 850.0
TLS2_k127_4077970_1 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000748 347.0
TLS2_k127_4077970_2 IrrE N-terminal-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003126 246.0
TLS2_k127_4077970_3 methyltransferase activity - - - 0.00000000000000000000000000000000000000002059 162.0
TLS2_k127_4077970_4 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000009163 142.0
TLS2_k127_4102306_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 2.061e-232 736.0
TLS2_k127_4102306_1 argininosuccinate lyase K01755 - 4.3.2.1 3.499e-212 670.0
TLS2_k127_4102306_10 Nucleotidyltransferase K09962 - - 0.000000000000000000000000000000000001071 156.0
TLS2_k127_4102306_11 PFAM Acetyltransferase (GNAT) family - - - 0.000000000000000000001851 102.0
TLS2_k127_4102306_12 Zinc-finger domain - - - 0.000000000000007257 78.0
TLS2_k127_4102306_13 STAS domain K06378 - - 0.0000000000003517 79.0
TLS2_k127_4102306_2 Domain of unknown function (DUF4175) - - - 2.178e-194 636.0
TLS2_k127_4102306_3 3-hydroxyacyl-coa dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 441.0
TLS2_k127_4102306_4 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 439.0
TLS2_k127_4102306_5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 427.0
TLS2_k127_4102306_6 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 388.0
TLS2_k127_4102306_7 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 361.0
TLS2_k127_4102306_8 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000001096 184.0
TLS2_k127_4102306_9 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000157 145.0
TLS2_k127_4159967_0 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes K00164 - 1.2.4.2 0.0 1255.0
TLS2_k127_4159967_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 596.0
TLS2_k127_4159967_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 534.0
TLS2_k127_4159967_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007271 521.0
TLS2_k127_4159967_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 479.0
TLS2_k127_4159967_5 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 367.0
TLS2_k127_4159967_6 Belongs to the pyridoxine kinase family K00868 - 2.7.1.35 0.00000000000000000000000000000000000000000000000000000001133 209.0
TLS2_k127_4159967_7 Proline imino-peptidase K01259 - 3.4.11.5 0.000000000006677 68.0
TLS2_k127_4161559_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.908e-277 860.0
TLS2_k127_4161559_1 Catalase K03781 - 1.11.1.6 1.101e-267 829.0
TLS2_k127_4161559_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003173 254.0
TLS2_k127_4161559_3 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000001454 233.0
TLS2_k127_4161559_4 Pfam:Pyridox_oxidase - - - 0.000000000000000000000000000000000000000000000000000002567 216.0
TLS2_k127_4161559_5 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000003245 175.0
TLS2_k127_4161559_6 Peptidase M48 K03799 - - 0.0000000000000000000003295 107.0
TLS2_k127_4183336_0 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 569.0
TLS2_k127_4183336_1 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 364.0
TLS2_k127_4183336_2 Carboxyl transferase domain K01969,K13778 - 6.4.1.4,6.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 333.0
TLS2_k127_4183336_3 AsmA family K07289 - - 0.000000000000000000000000000000000000000000000002507 196.0
TLS2_k127_4183336_4 Sortase family K07284 - 3.4.22.70 0.000000000000000000000000000003588 136.0
TLS2_k127_4200324_0 DEAD/H associated K03724 - - 0.0 1035.0
TLS2_k127_4200324_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 423.0
TLS2_k127_4200324_2 Calcineurin-like phosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004699 266.0
TLS2_k127_4200324_3 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000004653 171.0
TLS2_k127_4200324_4 NIPSNAP - - - 0.000000000000000000000000000000000000000000004851 165.0
TLS2_k127_4206509_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 7.453e-311 981.0
TLS2_k127_4206509_1 ABC-type dipeptide transport system, periplasmic component K02035 - - 5.138e-251 786.0
TLS2_k127_4206509_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.655e-224 707.0
TLS2_k127_4206509_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.554e-203 638.0
TLS2_k127_4206509_4 histidine ammonia-lyase activity K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 561.0
TLS2_k127_4206509_5 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 451.0
TLS2_k127_4206509_6 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000321 424.0
TLS2_k127_4206509_7 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009239 359.0
TLS2_k127_4206509_8 Thioredoxin K03672 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000004331 214.0
TLS2_k127_4206509_9 - - - - 0.000000000000000000004803 105.0
TLS2_k127_4253407_0 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 1.18e-212 676.0
TLS2_k127_4253407_1 PFAM Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 584.0
TLS2_k127_4253407_10 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003145 280.0
TLS2_k127_4253407_11 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000005669 241.0
TLS2_k127_4253407_12 BON domain - - - 0.00000000000000000000000000000000000000000000000000006619 193.0
TLS2_k127_4253407_13 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000006286 111.0
TLS2_k127_4253407_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003201 559.0
TLS2_k127_4253407_3 COG0402 Cytosine deaminase and related metal-dependent hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005478 514.0
TLS2_k127_4253407_4 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007678 480.0
TLS2_k127_4253407_5 PBP superfamily domain K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 469.0
TLS2_k127_4253407_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 409.0
TLS2_k127_4253407_7 signal transduction histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008633 347.0
TLS2_k127_4253407_8 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 321.0
TLS2_k127_4253407_9 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 334.0
TLS2_k127_439655_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.234e-235 743.0
TLS2_k127_439655_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006394 584.0
TLS2_k127_439655_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 453.0
TLS2_k127_439655_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000000000009638 235.0
TLS2_k127_439655_4 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000006304 236.0
TLS2_k127_439655_5 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000005329 230.0
TLS2_k127_439655_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000000000000000000001634 127.0
TLS2_k127_439655_7 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000008225 102.0
TLS2_k127_439655_8 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000000002243 83.0
TLS2_k127_4399887_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1302.0
TLS2_k127_4399887_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1141.0
TLS2_k127_4399887_10 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 531.0
TLS2_k127_4399887_11 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 505.0
TLS2_k127_4399887_12 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 491.0
TLS2_k127_4399887_13 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 469.0
TLS2_k127_4399887_14 Pyruvate ferredoxin/flavodoxin oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 484.0
TLS2_k127_4399887_15 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 440.0
TLS2_k127_4399887_16 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000072 430.0
TLS2_k127_4399887_17 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 428.0
TLS2_k127_4399887_18 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 421.0
TLS2_k127_4399887_19 CO dehydrogenase flavoprotein C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 346.0
TLS2_k127_4399887_2 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 1.515e-291 935.0
TLS2_k127_4399887_20 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003761 286.0
TLS2_k127_4399887_21 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009301 268.0
TLS2_k127_4399887_22 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003799 255.0
TLS2_k127_4399887_23 Carboxylesterase family K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000004036 257.0
TLS2_k127_4399887_24 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000576 207.0
TLS2_k127_4399887_25 Thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000000007588 201.0
TLS2_k127_4399887_26 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000001574 185.0
TLS2_k127_4399887_27 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000002468 162.0
TLS2_k127_4399887_28 SOS response K14160 - - 0.000000000000000000000000000000000000000004596 164.0
TLS2_k127_4399887_29 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000001495 152.0
TLS2_k127_4399887_3 Hydantoinase/oxoprolinase - - - 9.236e-288 915.0
TLS2_k127_4399887_30 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.00000000000000000000000000000000003779 146.0
TLS2_k127_4399887_4 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 1.387e-274 856.0
TLS2_k127_4399887_5 Hydantoinase B/oxoprolinase - - - 4.315e-263 837.0
TLS2_k127_4399887_6 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - - 1.464e-245 769.0
TLS2_k127_4399887_7 COG1180 Pyruvate-formate lyase-activating enzyme K20449 - 1.3.7.1 6.14e-236 746.0
TLS2_k127_4399887_8 Circadian clock protein kaic K08482 - - 1.048e-209 681.0
TLS2_k127_4399887_9 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 531.0
TLS2_k127_4421467_0 Glutathione S-transferase K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 456.0
TLS2_k127_4421467_1 ABC transporter substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 458.0
TLS2_k127_4421467_2 PQQ-dependent catabolism-associated beta-propeller protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 420.0
TLS2_k127_4421467_3 Isochorismatase family K08281 - 3.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 301.0
TLS2_k127_4421467_4 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000005338 139.0
TLS2_k127_4519509_0 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 591.0
TLS2_k127_4519509_1 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 537.0
TLS2_k127_4519509_10 SPFH domain / Band 7 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 388.0
TLS2_k127_4519509_11 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 361.0
TLS2_k127_4519509_12 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 354.0
TLS2_k127_4519509_13 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 379.0
TLS2_k127_4519509_14 PFAM binding-protein-dependent transport systems inner membrane component K13891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005162 323.0
TLS2_k127_4519509_15 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 328.0
TLS2_k127_4519509_16 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 314.0
TLS2_k127_4519509_17 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000003245 257.0
TLS2_k127_4519509_18 CHASE2 K01768,K01769 - 4.6.1.1,4.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000002426 278.0
TLS2_k127_4519509_19 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003289 241.0
TLS2_k127_4519509_2 Histidine kinase K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 517.0
TLS2_k127_4519509_20 LrgB-like family - - - 0.0000000000000000000000000000000000000000000000000000000003287 216.0
TLS2_k127_4519509_21 dephospho-CoA kinase activity - - - 0.0000000000000000000000000000000000000000001206 181.0
TLS2_k127_4519509_22 Histidine kinase-like ATPase domain - - - 0.0000000000000000000000000000001069 143.0
TLS2_k127_4519509_23 Major facilitator Superfamily K05820,K08217 - - 0.000000000000000000000000003928 124.0
TLS2_k127_4519509_24 - - - - 0.000000000000000000000001119 109.0
TLS2_k127_4519509_25 effector of murein hydrolase LrgA K06518 - - 0.0000000000000000000004678 102.0
TLS2_k127_4519509_26 Belongs to the anti-sigma-factor antagonist family K06378 - - 0.0000000000000000002698 94.0
TLS2_k127_4519509_27 PA14 domain - - - 0.000000000000002254 85.0
TLS2_k127_4519509_28 helix_turn_helix, Lux Regulon - - - 0.00017 55.0
TLS2_k127_4519509_29 helix_turn_helix, Lux Regulon - - - 0.0001944 45.0
TLS2_k127_4519509_3 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 471.0
TLS2_k127_4519509_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 418.0
TLS2_k127_4519509_5 Belongs to the ABC transporter superfamily K02031,K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 427.0
TLS2_k127_4519509_6 Major facilitator Superfamily K05820,K08217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 428.0
TLS2_k127_4519509_7 Bacterial extracellular solute-binding proteins, family 5 Middle K13889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 409.0
TLS2_k127_4519509_8 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649,K02594 - 2.3.3.13,2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 398.0
TLS2_k127_4519509_9 Belongs to the ABC transporter superfamily K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 406.0
TLS2_k127_45243_0 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000002303 183.0
TLS2_k127_45243_1 response regulator - - - 0.00000817 51.0
TLS2_k127_4553661_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 1.14e-322 1002.0
TLS2_k127_4553661_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1.087e-317 985.0
TLS2_k127_4553661_10 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 522.0
TLS2_k127_4553661_11 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 507.0
TLS2_k127_4553661_12 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 488.0
TLS2_k127_4553661_13 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 496.0
TLS2_k127_4553661_14 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 466.0
TLS2_k127_4553661_15 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 473.0
TLS2_k127_4553661_16 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 449.0
TLS2_k127_4553661_17 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 433.0
TLS2_k127_4553661_18 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004925 422.0
TLS2_k127_4553661_19 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K15598 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000777 436.0
TLS2_k127_4553661_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.804e-299 936.0
TLS2_k127_4553661_20 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 407.0
TLS2_k127_4553661_21 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 406.0
TLS2_k127_4553661_22 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 394.0
TLS2_k127_4553661_23 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 382.0
TLS2_k127_4553661_24 Enoyl-CoA hydratase/isomerase K01692,K05605 - 3.1.2.4,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 376.0
TLS2_k127_4553661_25 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 372.0
TLS2_k127_4553661_26 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 362.0
TLS2_k127_4553661_27 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 361.0
TLS2_k127_4553661_28 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 340.0
TLS2_k127_4553661_29 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 337.0
TLS2_k127_4553661_3 peptidase S45, penicillin amidase K01434 - 3.5.1.11 3.48e-257 817.0
TLS2_k127_4553661_30 MotA/TolQ/ExbB proton channel family K02556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 335.0
TLS2_k127_4553661_31 Proline racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 334.0
TLS2_k127_4553661_32 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 326.0
TLS2_k127_4553661_33 Acyclic terpene utilisation family protein AtuA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 319.0
TLS2_k127_4553661_34 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 317.0
TLS2_k127_4553661_35 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 317.0
TLS2_k127_4553661_36 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 316.0
TLS2_k127_4553661_37 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 306.0
TLS2_k127_4553661_38 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 306.0
TLS2_k127_4553661_39 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 300.0
TLS2_k127_4553661_4 Acyl-CoA dehydrogenase, N-terminal domain K00252 - 1.3.8.6 7.322e-215 673.0
TLS2_k127_4553661_40 Riboflavin synthase alpha chain K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 294.0
TLS2_k127_4553661_41 hydrolase (HAD superfamily) K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 294.0
TLS2_k127_4553661_42 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 293.0
TLS2_k127_4553661_43 protein required for cytochrome oxidase assembly K02259 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 298.0
TLS2_k127_4553661_44 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001199 281.0
TLS2_k127_4553661_45 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K15599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002776 287.0
TLS2_k127_4553661_46 uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005204 275.0
TLS2_k127_4553661_47 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001458 275.0
TLS2_k127_4553661_48 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000308 276.0
TLS2_k127_4553661_49 Carboxylesterase family K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000007351 254.0
TLS2_k127_4553661_5 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.1.2.1 6.11e-209 659.0
TLS2_k127_4553661_50 ABC transporter K15600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002781 264.0
TLS2_k127_4553661_51 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003504 248.0
TLS2_k127_4553661_52 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001859 246.0
TLS2_k127_4553661_53 Protein of unknown function (DUF1194) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002223 238.0
TLS2_k127_4553661_54 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000007517 220.0
TLS2_k127_4553661_55 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000001526 224.0
TLS2_k127_4553661_56 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000000001106 208.0
TLS2_k127_4553661_57 COG1846 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000000000001995 203.0
TLS2_k127_4553661_58 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000000002993 203.0
TLS2_k127_4553661_59 Acyclic terpene utilisation family protein AtuA - - - 0.0000000000000000000000000000000000000000000000000000001946 199.0
TLS2_k127_4553661_6 Beta-eliminating lyase K01738,K01740 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006429 602.0
TLS2_k127_4553661_60 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000003878 194.0
TLS2_k127_4553661_61 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000000000000000008649 195.0
TLS2_k127_4553661_62 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000000001692 186.0
TLS2_k127_4553661_63 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000002069 181.0
TLS2_k127_4553661_64 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000000000000000000000003856 171.0
TLS2_k127_4553661_65 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000000000000008439 173.0
TLS2_k127_4553661_66 Cupin domain - - - 0.000000000000000000000000000000000000000000001174 178.0
TLS2_k127_4553661_67 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000001239 167.0
TLS2_k127_4553661_68 ROS/MUCR transcriptional regulator protein - - - 0.00000000000000000000000000000000000000000002136 166.0
TLS2_k127_4553661_69 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000001259 153.0
TLS2_k127_4553661_7 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 596.0
TLS2_k127_4553661_70 MerR HTH family regulatory protein - - - 0.000000000000000000000000000000000000006599 156.0
TLS2_k127_4553661_71 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000000005888 147.0
TLS2_k127_4553661_72 Ubiquinol-cytochrome C chaperone K17662 - - 0.00000000000000000000000000000000004839 149.0
TLS2_k127_4553661_73 - - - - 0.0000000000000000000000000000000004952 144.0
TLS2_k127_4553661_74 COG2913 Small protein A (tmRNA-binding) - - - 0.000000000000000000000000000000002501 134.0
TLS2_k127_4553661_75 Pfam:Methyltransf_26 - - - 0.000000000000000000000000000000004483 140.0
TLS2_k127_4553661_76 Protein of unknown function (DUF3303) - - - 0.000000000000000000000000000000005383 149.0
TLS2_k127_4553661_77 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000008651 125.0
TLS2_k127_4553661_78 Uncharacterized ACR, COG1399 - - - 0.000000000000000000000000009498 116.0
TLS2_k127_4553661_79 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000002052 117.0
TLS2_k127_4553661_8 Cys/Met metabolism PLP-dependent enzyme K00643 - 2.3.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 588.0
TLS2_k127_4553661_80 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000000004693 107.0
TLS2_k127_4553661_81 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.000000002025 65.0
TLS2_k127_4553661_82 - - - - 0.00000000305 68.0
TLS2_k127_4553661_84 dehydrogenase - - - 0.0007204 44.0
TLS2_k127_4553661_9 COG1960 Acyl-CoA dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 564.0
TLS2_k127_4554506_0 AMP-binding enzyme C-terminal domain K01907 - 6.2.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 453.0
TLS2_k127_4554506_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008708 419.0
TLS2_k127_4554506_2 LysR substrate binding domain K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 370.0
TLS2_k127_4554506_3 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 386.0
TLS2_k127_4554506_4 L-asparaginase II - - - 0.0000000000004592 72.0
TLS2_k127_4554506_5 conserved small protein - - - 0.0000000005974 62.0
TLS2_k127_458994_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 8.433e-243 760.0
TLS2_k127_458994_1 protein involved in outer membrane biogenesis K07289 - - 0.0000000000000000000000000000000000000000000000000000000001338 217.0
TLS2_k127_4611016_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01908 - 6.2.1.17 1.318e-292 914.0
TLS2_k127_4611016_1 Amidase K02433 - 6.3.5.6,6.3.5.7 5.219e-211 668.0
TLS2_k127_4611016_2 Adenylate and Guanylate cyclase catalytic domain - - - 4.879e-208 655.0
TLS2_k127_4611016_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 551.0
TLS2_k127_4611016_4 transport systems, ATPase components K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 398.0
TLS2_k127_4611016_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 377.0
TLS2_k127_4611016_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002513 243.0
TLS2_k127_4611016_7 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000009868 240.0
TLS2_k127_461749_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 550.0
TLS2_k127_461749_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009392 496.0
TLS2_k127_461749_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 441.0
TLS2_k127_4664398_0 Dehydratase family K01687,K22186 - 4.2.1.82,4.2.1.9 0.0 1016.0
TLS2_k127_4664398_1 Amidohydrolase family - - - 5.258e-208 674.0
TLS2_k127_4664398_10 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 342.0
TLS2_k127_4664398_11 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 312.0
TLS2_k127_4664398_12 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 329.0
TLS2_k127_4664398_13 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 308.0
TLS2_k127_4664398_14 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007776 296.0
TLS2_k127_4664398_15 Acylneuraminate cytidylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002881 277.0
TLS2_k127_4664398_16 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000195 249.0
TLS2_k127_4664398_17 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000005222 207.0
TLS2_k127_4664398_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000158 178.0
TLS2_k127_4664398_19 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000006971 156.0
TLS2_k127_4664398_2 Peptidase family M20/M25/M40 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 630.0
TLS2_k127_4664398_20 Protein of unknown function (DUF3618) - - - 0.0000000000000000000000000000000000000009423 166.0
TLS2_k127_4664398_21 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000012 130.0
TLS2_k127_4664398_22 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000000000000000000000002531 115.0
TLS2_k127_4664398_23 - - - - 0.000000000001704 75.0
TLS2_k127_4664398_24 HMGL-like K01640 - 4.1.3.4 0.0000000004199 61.0
TLS2_k127_4664398_3 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005618 572.0
TLS2_k127_4664398_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 544.0
TLS2_k127_4664398_5 UDP-N-acetylglucosamine 2-epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 539.0
TLS2_k127_4664398_6 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 530.0
TLS2_k127_4664398_7 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 530.0
TLS2_k127_4664398_8 acetolactate synthase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000527 391.0
TLS2_k127_4664398_9 PFAM SAF domain K01654 - 2.5.1.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 372.0
TLS2_k127_4698620_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1215.0
TLS2_k127_4698620_1 Chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000929 366.0
TLS2_k127_4698620_2 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 317.0
TLS2_k127_4698620_3 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 302.0
TLS2_k127_4698620_4 Gram-negative porin K08720 - - 0.00000000000000000000000000000000000000000000000000000000000000000008939 245.0
TLS2_k127_4698620_5 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000000002935 204.0
TLS2_k127_4698620_6 Domain of unknown function (DUF3576) - - - 0.0000000000000000000000000000000000000000000000000001115 192.0
TLS2_k127_4698620_7 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0000000000000000000000000000000000000000000000000531 183.0
TLS2_k127_4698620_8 Lipopolysaccharide-assembly K03643 - - 0.0000000000000000000000000006682 120.0
TLS2_k127_4712020_0 PFAM Rieske 2Fe-2S domain protein - - - 2.417e-207 657.0
TLS2_k127_4712020_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001514 267.0
TLS2_k127_4712020_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002017 255.0
TLS2_k127_4712020_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000001145 259.0
TLS2_k127_4712020_4 PFAM Cell wall hydrolase - - - 0.0000000000000000000000000000000000000000000004917 175.0
TLS2_k127_4712020_5 Thioesterase superfamily - - - 0.0000000000000000000000000000000000006604 146.0
TLS2_k127_4712020_6 - - - - 0.00000000000000000001348 94.0
TLS2_k127_4712020_7 Domain of unknown function (DUF4170) - - - 0.00000000003215 76.0
TLS2_k127_4719419_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 9.862e-268 840.0
TLS2_k127_4719419_1 Ornithine cyclodeaminase/mu-crystallin family K01750,K19743 - 1.5.1.1,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000061 355.0
TLS2_k127_4719419_2 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000667 274.0
TLS2_k127_4719419_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000075 252.0
TLS2_k127_4719419_4 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.00000000000000000000000000000000000000000001011 165.0
TLS2_k127_4719419_5 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000001383 158.0
TLS2_k127_4719419_6 Lipopolysaccharide assembly protein A domain - - - 0.0000000000000005399 82.0
TLS2_k127_4719419_7 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000006114 69.0
TLS2_k127_4820712_0 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 604.0
TLS2_k127_4820712_1 Protein of unknown function (DUF993) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 559.0
TLS2_k127_4820712_10 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006434 288.0
TLS2_k127_4820712_11 Bacterial regulatory proteins, tetR family K09017 - - 0.000000000000000000000000000000000000000000000000000000000000001455 225.0
TLS2_k127_4820712_12 Belongs to the UPF0260 family K09160 - - 0.000000000000000000000000000000000000000000000000000000000007419 215.0
TLS2_k127_4820712_13 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000000000228 196.0
TLS2_k127_4820712_14 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000006704 158.0
TLS2_k127_4820712_15 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000005927 128.0
TLS2_k127_4820712_16 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000001447 113.0
TLS2_k127_4820712_17 - - - - 0.0000000000000000000008466 104.0
TLS2_k127_4820712_18 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000000000000005388 96.0
TLS2_k127_4820712_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 523.0
TLS2_k127_4820712_3 PHB de-polymerase C-terminus K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 502.0
TLS2_k127_4820712_4 Dihydrodipicolinate synthetase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 505.0
TLS2_k127_4820712_5 PFAM Enoyl-CoA hydratase isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 400.0
TLS2_k127_4820712_6 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 387.0
TLS2_k127_4820712_7 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 378.0
TLS2_k127_4820712_8 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 354.0
TLS2_k127_4820712_9 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 289.0
TLS2_k127_4835570_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - - 0.0 1166.0
TLS2_k127_4835570_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 1.383e-305 946.0
TLS2_k127_4835570_10 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 422.0
TLS2_k127_4835570_11 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008998 404.0
TLS2_k127_4835570_12 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 373.0
TLS2_k127_4835570_13 His Kinase A (phosphoacceptor) domain K14986 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 374.0
TLS2_k127_4835570_14 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 376.0
TLS2_k127_4835570_15 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 347.0
TLS2_k127_4835570_16 Belongs to the thiolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 335.0
TLS2_k127_4835570_17 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 324.0
TLS2_k127_4835570_18 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 317.0
TLS2_k127_4835570_19 Belongs to the thiolase family K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 316.0
TLS2_k127_4835570_2 Ring hydroxylating alpha subunit (catalytic domain) K00479,K16319 - 1.14.12.1 7.587e-214 670.0
TLS2_k127_4835570_20 KR domain K00059,K07535 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008259 316.0
TLS2_k127_4835570_21 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 299.0
TLS2_k127_4835570_22 COG0725 ABC-type molybdate transport system, periplasmic component K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003787 267.0
TLS2_k127_4835570_23 PFAM Glutathione S-transferase domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000004882 263.0
TLS2_k127_4835570_24 dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000187 268.0
TLS2_k127_4835570_25 carbon monoxide dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006219 269.0
TLS2_k127_4835570_26 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001588 250.0
TLS2_k127_4835570_27 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003124 232.0
TLS2_k127_4835570_28 Ring hydroxylating beta subunit - - - 0.000000000000000000000000000000000000000000000000000000000004883 213.0
TLS2_k127_4835570_29 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.00000000000000000000000000000000000000000000000000005039 195.0
TLS2_k127_4835570_3 Na phosphate symporter K03324 - - 1.371e-197 667.0
TLS2_k127_4835570_30 response regulator K14987 - - 0.00000000000000000000000000000000000000000000000003382 192.0
TLS2_k127_4835570_31 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000001512 172.0
TLS2_k127_4835570_32 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000003521 156.0
TLS2_k127_4835570_33 COG NOG14600 non supervised orthologous group - - - 0.000000000000000000000000000000000002146 139.0
TLS2_k127_4835570_34 regulatory protein GntR HTH - - - 0.0000000000000000000000007433 121.0
TLS2_k127_4835570_35 - - - - 0.00000000000000000000001242 102.0
TLS2_k127_4835570_36 response regulator receiver K13041 - - 0.00000000000000000002333 96.0
TLS2_k127_4835570_37 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000002086 83.0
TLS2_k127_4835570_38 Antibiotic biosynthesis monooxygenase - - - 0.000000000001063 71.0
TLS2_k127_4835570_39 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000004965 74.0
TLS2_k127_4835570_4 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005801 606.0
TLS2_k127_4835570_40 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.00000000003037 68.0
TLS2_k127_4835570_41 - - - - 0.00000000006293 64.0
TLS2_k127_4835570_42 - - - - 0.000000005712 57.0
TLS2_k127_4835570_5 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 540.0
TLS2_k127_4835570_6 Luciferase-like monooxygenase K17228 - 1.14.14.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 524.0
TLS2_k127_4835570_7 Beta-ketoacyl synthase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 512.0
TLS2_k127_4835570_8 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 470.0
TLS2_k127_4835570_9 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 446.0
TLS2_k127_4855856_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 4.269e-314 998.0
TLS2_k127_4855856_1 Belongs to the ABC transporter superfamily K13896 - - 7.068e-229 738.0
TLS2_k127_4855856_10 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 346.0
TLS2_k127_4855856_11 Polysaccharide pyruvyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 350.0
TLS2_k127_4855856_12 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 328.0
TLS2_k127_4855856_13 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 295.0
TLS2_k127_4855856_14 Dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005259 281.0
TLS2_k127_4855856_15 NlpC/P60 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007552 266.0
TLS2_k127_4855856_16 protein conserved in archaea K09726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004814 259.0
TLS2_k127_4855856_17 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.0000000000000000000000000000000000000000000000000000000000000000000000004897 254.0
TLS2_k127_4855856_18 UTRA K02043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000503 254.0
TLS2_k127_4855856_19 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000009294 252.0
TLS2_k127_4855856_2 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 3.719e-223 721.0
TLS2_k127_4855856_20 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000001578 227.0
TLS2_k127_4855856_21 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000000000000000000000000000000000000000000000008017 224.0
TLS2_k127_4855856_22 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000001577 191.0
TLS2_k127_4855856_23 Cytochrome c K08738 - - 0.00000000000000000000000000000000000000000000000489 181.0
TLS2_k127_4855856_24 transferase activity, transferring glycosyl groups K21366 - 2.4.1.122 0.00000000000000000000000000000000000000009342 171.0
TLS2_k127_4855856_25 COG1846 Transcriptional regulators - - - 0.000000000000000000000000000004328 137.0
TLS2_k127_4855856_26 Methyltransferase FkbM domain - - - 0.0000000000000000000000001706 115.0
TLS2_k127_4855856_27 Glycosyl transferases group 1 - - - 0.000000000000000000000001453 116.0
TLS2_k127_4855856_28 Heavy-metal resistance - - - 0.0000003792 61.0
TLS2_k127_4855856_3 ABC-type oligopeptide transport system, periplasmic component K02035,K13893 - - 4.991e-195 627.0
TLS2_k127_4855856_4 transport system, permease component K13895 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 554.0
TLS2_k127_4855856_5 transport system, permease component K13894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 549.0
TLS2_k127_4855856_6 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 522.0
TLS2_k127_4855856_7 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 434.0
TLS2_k127_4855856_8 Protein of unknown function (DUF563) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000847 371.0
TLS2_k127_4855856_9 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 348.0
TLS2_k127_4856423_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K16876 - 6.2.1.31 5.624e-233 732.0
TLS2_k127_4856423_1 Glucose / Sorbosone dehydrogenase - - - 7.953e-199 631.0
TLS2_k127_4856423_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596,K07250 - 2.6.1.19,2.6.1.22,4.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005735 519.0
TLS2_k127_4856423_3 [2Fe-2S] binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000006091 232.0
TLS2_k127_4856423_4 Belongs to the enoyl-CoA hydratase isomerase family K15016 - 1.1.1.35,4.2.1.17 0.00000000000000000000000000000000000000002324 165.0
TLS2_k127_4856423_5 Peptidase family M23 - - - 0.00000000000000000000000000004869 119.0
TLS2_k127_4884010_0 AMP-binding enzyme C-terminal domain K00666 - - 1.928e-256 799.0
TLS2_k127_4884010_1 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 547.0
TLS2_k127_4884010_2 Protein of unknown function (DUF1013) K09987 - - 0.00000000000000000000000000000000000000001912 159.0
TLS2_k127_4884010_3 Protein of unknown function (DUF465) - - - 0.0000000000000005648 79.0
TLS2_k127_4884010_4 Protein of unknown function (DUF465) - - - 0.000131 49.0
TLS2_k127_4963395_0 Aconitase family (aconitate hydratase) K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 497.0
TLS2_k127_4963395_1 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 398.0
TLS2_k127_4963395_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008842 360.0
TLS2_k127_4963395_3 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006288 316.0
TLS2_k127_4963395_4 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000301 282.0
TLS2_k127_4963395_5 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003202 271.0
TLS2_k127_4963395_6 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.0000000000000000000000000000000000000000000000000000001344 199.0
TLS2_k127_4963395_7 Aconitase C-terminal domain K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000135 180.0
TLS2_k127_4995270_0 epimerase dehydratase K12454 - 5.1.3.10 2.523e-260 837.0
TLS2_k127_4995270_1 alcohol dehydrogenase - - - 4.842e-219 686.0
TLS2_k127_4995270_10 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005271 283.0
TLS2_k127_4995270_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002413 249.0
TLS2_k127_4995270_12 - - - - 0.000000000000000000000004578 116.0
TLS2_k127_4995270_2 SMART Elongator protein 3 MiaB NifB - - - 3.663e-213 687.0
TLS2_k127_4995270_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 571.0
TLS2_k127_4995270_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 545.0
TLS2_k127_4995270_5 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 543.0
TLS2_k127_4995270_6 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 484.0
TLS2_k127_4995270_7 NAD-dependent epimerase dehydratase K01784,K08678,K12454,K17947 - 4.1.1.35,5.1.3.10,5.1.3.2,5.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006692 453.0
TLS2_k127_4995270_8 PFAM NAD-dependent epimerase dehydratase K08678 - 4.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 436.0
TLS2_k127_4995270_9 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005018 330.0
TLS2_k127_5010649_0 SMART Elongator protein 3 MiaB NifB - - - 4.263e-239 753.0
TLS2_k127_5010649_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000436 250.0
TLS2_k127_5010649_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.00000000000000000000000000000000000000000000000000003751 189.0
TLS2_k127_5010649_3 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000003173 86.0
TLS2_k127_5010649_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0002294 44.0
TLS2_k127_5105299_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18989 - - 0.0 1253.0
TLS2_k127_5105299_1 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 1.263e-310 964.0
TLS2_k127_5105299_10 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 306.0
TLS2_k127_5105299_11 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 312.0
TLS2_k127_5105299_12 Barrel-sandwich domain of CusB or HlyD membrane-fusion K18990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 312.0
TLS2_k127_5105299_13 Isochorismatase family K13995 - 3.5.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 297.0
TLS2_k127_5105299_14 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 320.0
TLS2_k127_5105299_15 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 316.0
TLS2_k127_5105299_16 Isochorismatase family K13995 - 3.5.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002663 282.0
TLS2_k127_5105299_17 Belongs to the ABC transporter superfamily K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000532 289.0
TLS2_k127_5105299_18 ABC-type spermidine putrescine transport system, permease component II K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006026 284.0
TLS2_k127_5105299_19 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001134 308.0
TLS2_k127_5105299_2 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 1.616e-299 980.0
TLS2_k127_5105299_20 isochorismatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006277 283.0
TLS2_k127_5105299_21 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000005342 275.0
TLS2_k127_5105299_22 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008203 247.0
TLS2_k127_5105299_23 ABC-type spermidine putrescine transport system, permease component I K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000001858 245.0
TLS2_k127_5105299_24 LysM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001854 234.0
TLS2_k127_5105299_25 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000001319 219.0
TLS2_k127_5105299_26 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000161 175.0
TLS2_k127_5105299_27 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000005876 177.0
TLS2_k127_5105299_28 Telomere recombination - - - 0.00000000000000000000000000000000000000005635 161.0
TLS2_k127_5105299_29 E-Z type HEAT repeats - - - 0.00000000004074 76.0
TLS2_k127_5105299_3 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 2.978e-299 936.0
TLS2_k127_5105299_30 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000001502 58.0
TLS2_k127_5105299_4 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 1.608e-292 919.0
TLS2_k127_5105299_5 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 9.883e-246 772.0
TLS2_k127_5105299_6 Major Facilitator Superfamily K08167 - - 1.977e-199 634.0
TLS2_k127_5105299_7 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 507.0
TLS2_k127_5105299_8 Required for the activity of the bacterial periplasmic transport system of putrescine K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 424.0
TLS2_k127_5105299_9 RimK-like ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 356.0
TLS2_k127_5111719_0 4Fe-4S dicluster domain - - - 1.215e-297 932.0
TLS2_k127_5111719_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 3.278e-250 784.0
TLS2_k127_5111719_10 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008599 351.0
TLS2_k127_5111719_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004513 253.0
TLS2_k127_5111719_12 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007272 245.0
TLS2_k127_5111719_13 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000677 226.0
TLS2_k127_5111719_14 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000009148 198.0
TLS2_k127_5111719_15 Histidine kinase - - - 0.000000000000000000000000000006906 136.0
TLS2_k127_5111719_16 Protein conserved in bacteria K09796 - - 0.000000000000000004246 97.0
TLS2_k127_5111719_17 - - - - 0.000000002906 61.0
TLS2_k127_5111719_2 Bacterial regulatory protein, Fis family K10912 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 604.0
TLS2_k127_5111719_3 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003788 593.0
TLS2_k127_5111719_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 572.0
TLS2_k127_5111719_5 Alkyl sulfatase dimerisation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 486.0
TLS2_k127_5111719_6 acetyl-coa acetyltransferase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 478.0
TLS2_k127_5111719_7 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 453.0
TLS2_k127_5111719_8 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007426 385.0
TLS2_k127_5111719_9 Cytochrome c3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 386.0
TLS2_k127_5115939_0 acetyl-coa acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 476.0
TLS2_k127_5115939_1 hemolysin activation secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 443.0
TLS2_k127_5115939_10 V4R - - - 0.0000000000000000000007129 111.0
TLS2_k127_5115939_11 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000000004221 86.0
TLS2_k127_5115939_12 Integrase core domain - - - 0.0000000000000002471 92.0
TLS2_k127_5115939_14 Transposase and inactivated derivatives - - - 0.00000003097 67.0
TLS2_k127_5115939_2 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 330.0
TLS2_k127_5115939_3 haemagglutination activity domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 328.0
TLS2_k127_5115939_4 flavin adenine dinucleotide binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002378 274.0
TLS2_k127_5115939_5 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000883 278.0
TLS2_k127_5115939_6 PRC-barrel domain - - - 0.0000000000000000000000000000000000000004575 153.0
TLS2_k127_5115939_7 SnoaL-like domain - - - 0.00000000000000000000000000000000004851 137.0
TLS2_k127_5115939_8 LysM domain - - - 0.0000000000000000000000000000000001005 149.0
TLS2_k127_5115939_9 type I secretion target repeat protein - - - 0.000000000000000000000000004084 124.0
TLS2_k127_5133386_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 372.0
TLS2_k127_5133386_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 326.0
TLS2_k127_5133386_10 ChrR Cupin-like domain - - - 0.00000000000000000000000000000000000000000000000006125 183.0
TLS2_k127_5133386_11 Belongs to the bacterial histone-like protein family K03530 - - 0.0000000000000000000000000000000000001152 143.0
TLS2_k127_5133386_12 KR domain - - - 0.00000000000000000000000000002665 119.0
TLS2_k127_5133386_2 ABC transporter K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 307.0
TLS2_k127_5133386_3 Branched-chain amino acid aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 289.0
TLS2_k127_5133386_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002678 278.0
TLS2_k127_5133386_5 sodium ABC transporter, permease K09696 - - 0.000000000000000000000000000000000000000000000000000000000000000000001344 260.0
TLS2_k127_5133386_6 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001182 241.0
TLS2_k127_5133386_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000125 192.0
TLS2_k127_5133386_8 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000000000000000000000000000000000003168 211.0
TLS2_k127_5133386_9 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000001549 186.0
TLS2_k127_5143382_0 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 1.454e-269 839.0
TLS2_k127_5143382_1 Amidase - - - 5.836e-248 777.0
TLS2_k127_5143382_10 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 412.0
TLS2_k127_5143382_11 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 396.0
TLS2_k127_5143382_12 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 370.0
TLS2_k127_5143382_13 KR domain K00059,K07535 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 351.0
TLS2_k127_5143382_14 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 340.0
TLS2_k127_5143382_15 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 335.0
TLS2_k127_5143382_16 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005587 327.0
TLS2_k127_5143382_17 ATPases associated with a variety of cellular activities K01996,K11963 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 320.0
TLS2_k127_5143382_18 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000004202 182.0
TLS2_k127_5143382_19 PIN domain K07062 - - 0.000000000000000000000000000000000000008246 153.0
TLS2_k127_5143382_2 Acyclic terpene utilisation family protein AtuA - - - 3.822e-217 690.0
TLS2_k127_5143382_20 response regulator K13589 - - 0.000000000000000000000000000000000004406 155.0
TLS2_k127_5143382_21 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000004659 119.0
TLS2_k127_5143382_22 PA14 domain - - - 0.00000000000000000000001214 109.0
TLS2_k127_5143382_23 Nucleotidyltransferase domain K07075 - - 0.00000000000000000000002042 104.0
TLS2_k127_5143382_24 Outer membrane protein beta-barrel domain - - - 0.000000000000000001207 100.0
TLS2_k127_5143382_25 Protein of unknown function DUF86 - - - 0.000000000006677 70.0
TLS2_k127_5143382_26 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00004187 55.0
TLS2_k127_5143382_3 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 9.722e-202 641.0
TLS2_k127_5143382_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 636.0
TLS2_k127_5143382_5 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 551.0
TLS2_k127_5143382_6 Acetamidase/Formamidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 541.0
TLS2_k127_5143382_7 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 546.0
TLS2_k127_5143382_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 501.0
TLS2_k127_5143382_9 Branched-chain amino acid transport system / permease component K01998,K11961 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 445.0
TLS2_k127_5185207_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 1.951e-309 968.0
TLS2_k127_5185207_1 amine dehydrogenase activity - - - 5.159e-298 930.0
TLS2_k127_5185207_10 Thiolase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 519.0
TLS2_k127_5185207_11 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 438.0
TLS2_k127_5185207_12 Belongs to the binding-protein-dependent transport system permease family K01998,K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 402.0
TLS2_k127_5185207_13 Belongs to the binding-protein-dependent transport system permease family K01997,K11960 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 370.0
TLS2_k127_5185207_14 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 370.0
TLS2_k127_5185207_15 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008386 362.0
TLS2_k127_5185207_16 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 341.0
TLS2_k127_5185207_17 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 319.0
TLS2_k127_5185207_18 ATPases associated with a variety of cellular activities K01995,K11962 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 330.0
TLS2_k127_5185207_19 short-chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 316.0
TLS2_k127_5185207_2 Belongs to the amidase family K01426 - 3.5.1.4 6.11e-248 787.0
TLS2_k127_5185207_20 BtpA family K06971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 312.0
TLS2_k127_5185207_21 Sugar (and other) transporter K07552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 301.0
TLS2_k127_5185207_22 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 304.0
TLS2_k127_5185207_23 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 288.0
TLS2_k127_5185207_24 Putative transmembrane protein (Alph_Pro_TM) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007577 264.0
TLS2_k127_5185207_25 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000001276 272.0
TLS2_k127_5185207_26 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000002472 289.0
TLS2_k127_5185207_27 Universal stress protein UspA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009308 246.0
TLS2_k127_5185207_28 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000004272 248.0
TLS2_k127_5185207_29 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000005783 220.0
TLS2_k127_5185207_3 PFAM copper amine oxidase K00276 - 1.4.3.21 1.264e-242 768.0
TLS2_k127_5185207_30 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000002991 205.0
TLS2_k127_5185207_31 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000001727 209.0
TLS2_k127_5185207_32 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000001312 212.0
TLS2_k127_5185207_33 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000001028 187.0
TLS2_k127_5185207_34 2-oxopent-4-enoate hydratase activity - - - 0.000000000000000000000000000000000000009434 156.0
TLS2_k127_5185207_35 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000000000000000000000000000005538 145.0
TLS2_k127_5185207_37 transcriptional regulators K22042 - - 0.000000000000000000000000000000002337 131.0
TLS2_k127_5185207_38 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000002528 134.0
TLS2_k127_5185207_39 - - - - 0.00000000000000000000000000005071 118.0
TLS2_k127_5185207_4 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 5.843e-230 749.0
TLS2_k127_5185207_40 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000007052 127.0
TLS2_k127_5185207_41 Glyoxalase-like domain - - - 0.00000000000000000000000000008571 135.0
TLS2_k127_5185207_42 Transposase DDE domain - - - 0.0000000000000000000000001064 114.0
TLS2_k127_5185207_43 PFAM transposase, IS4 family protein - - - 0.00000000000000000000000292 114.0
TLS2_k127_5185207_44 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000008988 106.0
TLS2_k127_5185207_46 Biotin-requiring enzyme - - - 0.0000000000000000876 83.0
TLS2_k127_5185207_47 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000003755 78.0
TLS2_k127_5185207_48 PIN domain - - - 0.000000000000005751 85.0
TLS2_k127_5185207_49 lactoylglutathione lyase activity - - - 0.000001777 56.0
TLS2_k127_5185207_5 Fusion of two proteins both involved in carbon metabolism a sugar xylulose kinase in the first half of the CDS and ribulose-phosphate 3 epimerase in the 3'half - - - 3.649e-196 623.0
TLS2_k127_5185207_6 Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 584.0
TLS2_k127_5185207_7 Gamma-glutamyltranspeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 580.0
TLS2_k127_5185207_8 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 576.0
TLS2_k127_5185207_9 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 529.0
TLS2_k127_519315_0 Acyl-CoA dehydrogenase, C-terminal domain K14448 - 1.3.8.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008304 577.0
TLS2_k127_519315_1 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 473.0
TLS2_k127_519315_10 dehydratase K18290 - 4.2.1.56 0.0000000000000000000000000000000000000000000000000000000000000000001013 235.0
TLS2_k127_519315_11 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000004296 214.0
TLS2_k127_519315_12 Glycosyl transferases group 1 K13684 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000005523 190.0
TLS2_k127_519315_13 Putative beta-barrel porin 2 - - - 0.0000000000000000000000000000000000000000000000009845 190.0
TLS2_k127_519315_14 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000000000000000000000000000008346 178.0
TLS2_k127_519315_15 Streptomycin adenylyltransferase K05593 - - 0.00000000000000000000000000000000000000000001854 173.0
TLS2_k127_519315_16 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000007772 171.0
TLS2_k127_519315_17 Transcriptional regulator, Crp Fnr family - - - 0.000000000000000000000000000000000000268 153.0
TLS2_k127_519315_18 Glycosyl transferases group 1 K13684 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000002421 140.0
TLS2_k127_519315_19 nucleotide phosphatase activity, acting on free nucleotides - - - 0.0000000000000000000000236 117.0
TLS2_k127_519315_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 485.0
TLS2_k127_519315_20 Uncharacterised nucleotidyltransferase - - - 0.00000000000001141 88.0
TLS2_k127_519315_21 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000001729 66.0
TLS2_k127_519315_22 - - - - 0.00000000004308 73.0
TLS2_k127_519315_3 metal-dependent hydrolase of the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 452.0
TLS2_k127_519315_4 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 449.0
TLS2_k127_519315_5 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 380.0
TLS2_k127_519315_6 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 377.0
TLS2_k127_519315_7 Acetyl-CoA hydrolase/transferase N-terminal domain K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 361.0
TLS2_k127_519315_8 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006156 280.0
TLS2_k127_519315_9 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003102 271.0
TLS2_k127_5242881_0 Belongs to the thiolase family K00626 - 2.3.1.9 3.664e-194 612.0
TLS2_k127_5242881_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 496.0
TLS2_k127_5242881_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 424.0
TLS2_k127_5242881_3 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 410.0
TLS2_k127_5242881_4 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 419.0
TLS2_k127_5242881_5 Acetoacetyl-CoA reductase K00023 - 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 381.0
TLS2_k127_5242881_6 alpha/beta hydrolase fold K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 353.0
TLS2_k127_5242881_7 COG1178 ABC-type Fe3 transport system, permease component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000001399 236.0
TLS2_k127_5242881_8 Polyhydroxyalkanoate synthesis repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000001067 238.0
TLS2_k127_5298485_0 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 601.0
TLS2_k127_5298485_1 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 418.0
TLS2_k127_5298485_2 Malate/L-lactate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 407.0
TLS2_k127_5298485_3 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007427 339.0
TLS2_k127_5298485_4 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 300.0
TLS2_k127_5298485_5 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006192 277.0
TLS2_k127_5298485_6 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000000000000000003638 179.0
TLS2_k127_5298485_7 Protein of unknown function (DUF559) - - - 0.00000000000000000000000000000003686 133.0
TLS2_k127_5298485_8 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000003603 64.0
TLS2_k127_5336990_0 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 5.718e-218 688.0
TLS2_k127_5336990_1 COG0402 Cytosine deaminase and related metal-dependent hydrolases - - - 4.945e-194 615.0
TLS2_k127_5336990_2 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 505.0
TLS2_k127_5336990_3 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009883 410.0
TLS2_k127_5336990_4 FIST N domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 388.0
TLS2_k127_5336990_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000001466 179.0
TLS2_k127_5336990_6 - - - - 0.00000000000000000000000000000004322 129.0
TLS2_k127_535254_0 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 517.0
TLS2_k127_535254_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 422.0
TLS2_k127_535254_2 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 382.0
TLS2_k127_535254_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000669 321.0
TLS2_k127_535254_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000001969 270.0
TLS2_k127_535254_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000004659 195.0
TLS2_k127_535254_6 membrane transporter protein - - - 0.0000000000000000000000000000000000000000000000000002477 203.0
TLS2_k127_535254_7 integral membrane protein - - - 0.0000000000000000000000000000000000001262 147.0
TLS2_k127_535254_8 Protein of unknown function (DUF1674) - - - 0.000000000007118 67.0
TLS2_k127_5449024_0 Flavoprotein involved in K transport K03379,K21730 - 1.14.13.160,1.14.13.22 1.081e-256 804.0
TLS2_k127_5449024_1 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 490.0
TLS2_k127_5449024_2 Luciferase-like monooxygenase K15854 - 1.14.14.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 342.0
TLS2_k127_5449024_3 Protein of unknown function (DUF3309) - - - 0.000000000000000001621 87.0
TLS2_k127_5449024_4 Luciferase-like monooxygenase - - - 0.000000000007246 67.0
TLS2_k127_5466596_0 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 1.008e-317 993.0
TLS2_k127_5466596_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.187e-208 660.0
TLS2_k127_5466596_10 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 334.0
TLS2_k127_5466596_11 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 319.0
TLS2_k127_5466596_12 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 320.0
TLS2_k127_5466596_13 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 310.0
TLS2_k127_5466596_14 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 303.0
TLS2_k127_5466596_15 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008375 269.0
TLS2_k127_5466596_16 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002601 270.0
TLS2_k127_5466596_17 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006951 252.0
TLS2_k127_5466596_18 Acts on guanine, xanthine and to a lesser extent hypoxanthine K00769 - 2.4.2.22 0.00000000000000000000000000000000000000000000000000000000000000000000002434 244.0
TLS2_k127_5466596_19 Domain of Unknown Function (DUF1206) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000455 250.0
TLS2_k127_5466596_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 5.706e-204 663.0
TLS2_k127_5466596_20 FGGY family of carbohydrate kinases, N-terminal domain K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000005849 207.0
TLS2_k127_5466596_21 SapC - - - 0.000000000000000000000000000000000000000000000000000000275 213.0
TLS2_k127_5466596_22 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.000000000000000000000000000000000000000000000000000006192 196.0
TLS2_k127_5466596_23 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000008246 156.0
TLS2_k127_5466596_24 Ca2 -binding protein (EF-Hand superfamily - - - 0.0000000000000000000009911 102.0
TLS2_k127_5466596_25 Evidence 4 Homologs of previously reported genes of K21440 - - 0.00000000000001291 89.0
TLS2_k127_5466596_26 SMART ATPase, AAA type, core K02450 - - 0.00000000005079 77.0
TLS2_k127_5466596_3 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 551.0
TLS2_k127_5466596_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 481.0
TLS2_k127_5466596_5 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 371.0
TLS2_k127_5466596_6 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 384.0
TLS2_k127_5466596_7 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 376.0
TLS2_k127_5466596_8 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K08319 - 1.1.1.411 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009802 345.0
TLS2_k127_5466596_9 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 337.0
TLS2_k127_5501478_0 Carboxyl transferase domain - - - 3.475e-205 657.0
TLS2_k127_5501478_1 KR domain - - - 0.00000000000000000000000000000000000000000000000004167 198.0
TLS2_k127_5501478_2 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.00000000000000000000000000000000000000002358 153.0
TLS2_k127_5501478_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000001072 98.0
TLS2_k127_5567316_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 379.0
TLS2_k127_5567316_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00651 - 2.3.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 352.0
TLS2_k127_5567316_2 Carboxylesterase family K01066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003698 252.0
TLS2_k127_5567316_3 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000000000119 191.0
TLS2_k127_5567316_4 Dopa 4,5-dioxygenase family K10253 - - 0.000000000000000000000000000000000003102 149.0
TLS2_k127_5567316_5 Belongs to the BolA IbaG family - - - 0.000000000000000000000000000000000007434 137.0
TLS2_k127_5574378_0 COG1680 Beta-lactamase class C and other penicillin binding proteins K01286,K08641 - 3.4.13.22,3.4.16.4 8.136e-209 659.0
TLS2_k127_5574378_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 571.0
TLS2_k127_5574378_10 cheY-homologous receiver domain - - - 0.00000000000000000000007801 105.0
TLS2_k127_5574378_11 PFAM Methyltransferase type 11 - - - 0.0000004734 52.0
TLS2_k127_5574378_2 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 446.0
TLS2_k127_5574378_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006492 370.0
TLS2_k127_5574378_4 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009142 276.0
TLS2_k127_5574378_5 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001159 287.0
TLS2_k127_5574378_6 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000102 250.0
TLS2_k127_5574378_7 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000295 224.0
TLS2_k127_5574378_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000007193 194.0
TLS2_k127_5574378_9 Putative stress-induced transcription regulator - - - 0.0000000000000000000000000000000000000000000000008982 181.0
TLS2_k127_5657941_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 4.031e-280 868.0
TLS2_k127_5657941_1 Molecular chaperone. Has ATPase activity K04079 - - 9.411e-257 805.0
TLS2_k127_5657941_10 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000001079 245.0
TLS2_k127_5657941_11 RES - - - 0.00000000000000000000000000000000000000000000000000000000000000000003936 235.0
TLS2_k127_5657941_12 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000001708 239.0
TLS2_k127_5657941_13 Protein of unknown function (DUF1223) - - - 0.0000000000000000000000000000000000000000000000000000000000000008909 226.0
TLS2_k127_5657941_14 Domain of unknown function (DUF4340) - - - 0.00000000000000000000000000000000000000000000000003279 192.0
TLS2_k127_5657941_15 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000001706 183.0
TLS2_k127_5657941_16 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000001173 166.0
TLS2_k127_5657941_17 Cyclophilin-like - - - 0.000000000000007288 88.0
TLS2_k127_5657941_18 Protein of unknown function (DUF1289) K06938 - - 0.0000000000002371 71.0
TLS2_k127_5657941_19 Cyclophilin-like K09143 - - 0.000000000193 66.0
TLS2_k127_5657941_2 MlrC C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 590.0
TLS2_k127_5657941_3 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 539.0
TLS2_k127_5657941_4 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 433.0
TLS2_k127_5657941_5 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 401.0
TLS2_k127_5657941_6 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 381.0
TLS2_k127_5657941_7 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 366.0
TLS2_k127_5657941_8 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003041 261.0
TLS2_k127_5657941_9 Protein of unknown function (DUF3445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001659 266.0
TLS2_k127_5727476_0 Proton-conducting membrane transporter K00341,K05568 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 580.0
TLS2_k127_5727476_1 Proton-conducting membrane transporter K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 579.0
TLS2_k127_5727476_10 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000001959 221.0
TLS2_k127_5727476_11 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.00000000000000000000000000000000000000000000000000000000005813 209.0
TLS2_k127_5727476_12 carbon monoxide dehydrogenase K09386 - - 0.0000000000000000000000000000000000000000000000000000001203 203.0
TLS2_k127_5727476_13 Domain of unknown function (DUF4040) K05566 - - 0.0000000000000000000000000000000000000000000000000001187 193.0
TLS2_k127_5727476_14 Cold shock protein domain K03704 - - 0.000000000000000000000000000000000000000000000000005995 188.0
TLS2_k127_5727476_15 Na H antiporter, MnhB - - - 0.000000000000000000000000000000000000000000005713 177.0
TLS2_k127_5727476_16 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000000000000007568 151.0
TLS2_k127_5727476_17 Na+/H+ ion antiporter subunit - - - 0.00000000000000000000000000000000005849 142.0
TLS2_k127_5727476_18 Ring hydroxylating beta subunit - - - 0.00000000000000000000000000000007054 141.0
TLS2_k127_5727476_19 monovalent cation:proton antiporter activity K05571 - - 0.000000000000000000000000004708 124.0
TLS2_k127_5727476_2 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 530.0
TLS2_k127_5727476_20 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.00000000000000000000000002365 110.0
TLS2_k127_5727476_21 PFAM thioesterase superfamily - - - 0.0000000000000000001174 97.0
TLS2_k127_5727476_22 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518 - 1.2.5.3 0.000000001674 62.0
TLS2_k127_5727476_23 - - - - 0.0001174 55.0
TLS2_k127_5727476_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 437.0
TLS2_k127_5727476_4 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00479,K05549,K05708 - 1.14.12.10,1.14.12.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 406.0
TLS2_k127_5727476_5 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 323.0
TLS2_k127_5727476_6 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 299.0
TLS2_k127_5727476_7 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007817 274.0
TLS2_k127_5727476_8 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003436 270.0
TLS2_k127_5727476_9 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003852 250.0
TLS2_k127_5809373_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.953e-304 945.0
TLS2_k127_5809373_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 1.52e-225 713.0
TLS2_k127_5809373_10 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000002376 188.0
TLS2_k127_5809373_11 - - - - 0.000000000000001152 86.0
TLS2_k127_5809373_12 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000001861 58.0
TLS2_k127_5809373_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 526.0
TLS2_k127_5809373_3 Cysteine synthase K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 459.0
TLS2_k127_5809373_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006614 386.0
TLS2_k127_5809373_5 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 361.0
TLS2_k127_5809373_6 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 365.0
TLS2_k127_5809373_7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 336.0
TLS2_k127_5809373_8 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000004039 227.0
TLS2_k127_5809373_9 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000001167 183.0
TLS2_k127_581126_0 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 4.085e-255 803.0
TLS2_k127_581126_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 6.03e-250 786.0
TLS2_k127_581126_10 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 284.0
TLS2_k127_581126_11 HWE histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009627 270.0
TLS2_k127_581126_13 Pfam Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007902 247.0
TLS2_k127_581126_14 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003836 248.0
TLS2_k127_581126_15 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000001469 213.0
TLS2_k127_581126_16 Gram-negative porin K08720 - - 0.000000000000000000000000000000000000000000000000002271 197.0
TLS2_k127_581126_17 GIY-YIG catalytic domain K07461 - - 0.00000000000000000000000000000000000008932 146.0
TLS2_k127_581126_18 Ring hydroxylating beta subunit K16320 - 1.14.12.1 0.00000000000000000000000000000008745 135.0
TLS2_k127_581126_19 - - - - 0.000000000000000000000000000000201 139.0
TLS2_k127_581126_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009707 568.0
TLS2_k127_581126_20 Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000001937 112.0
TLS2_k127_581126_21 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.00000000000000000000002698 114.0
TLS2_k127_581126_22 - - - - 0.0000000000000000000001675 114.0
TLS2_k127_581126_23 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000001856 105.0
TLS2_k127_581126_24 - - - - 0.00000000000005935 83.0
TLS2_k127_581126_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009011 474.0
TLS2_k127_581126_4 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 457.0
TLS2_k127_581126_5 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K16319,K18074 - 1.14.12.1,1.14.12.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 419.0
TLS2_k127_581126_6 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005069 362.0
TLS2_k127_581126_7 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 349.0
TLS2_k127_581126_8 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005752 353.0
TLS2_k127_581126_9 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 300.0
TLS2_k127_5814122_0 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 441.0
TLS2_k127_5814122_1 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 344.0
TLS2_k127_5814122_2 III protein, CoA-transferase family K07749 - 2.8.3.16 0.00000004705 55.0
TLS2_k127_5863410_0 Methionine synthase K00548 - 2.1.1.13 0.0 1642.0
TLS2_k127_5863410_1 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 2.76e-320 1002.0
TLS2_k127_5863410_10 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000000000004536 246.0
TLS2_k127_5863410_11 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003043 242.0
TLS2_k127_5863410_12 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.000000000000000000000000000000000001363 153.0
TLS2_k127_5863410_13 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000000000008548 107.0
TLS2_k127_5863410_14 - - - - 0.00000005592 58.0
TLS2_k127_5863410_2 PFAM Glycoside hydrolase 15-related - - - 1.428e-316 995.0
TLS2_k127_5863410_3 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 2.541e-280 871.0
TLS2_k127_5863410_4 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 4.02e-235 767.0
TLS2_k127_5863410_5 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 508.0
TLS2_k127_5863410_6 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 407.0
TLS2_k127_5863410_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 374.0
TLS2_k127_5863410_8 MlaA lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005814 255.0
TLS2_k127_5863410_9 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001843 239.0
TLS2_k127_5878277_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 522.0
TLS2_k127_5878277_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 359.0
TLS2_k127_5878277_2 breast cancer carboxy-terminal domain K01972 - 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 336.0
TLS2_k127_5885679_0 carbamoyl transferase, NodU family K00612 - - 6.043e-240 755.0
TLS2_k127_5885679_1 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 415.0
TLS2_k127_5885679_2 TIGRFAM amidohydrolase, AtzE family K02433,K19837 - 3.5.1.84,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 356.0
TLS2_k127_5885679_3 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 329.0
TLS2_k127_5885679_4 Tyrosine phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000000000005806 196.0
TLS2_k127_5885679_5 Protein of unknown function (DUF4089) - - - 0.000005329 52.0
TLS2_k127_5885679_6 Phage head-tail joining protein - - - 0.000191 50.0
TLS2_k127_5887159_0 CoA-binding domain protein - - - 2.781e-201 650.0
TLS2_k127_5887159_1 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 540.0
TLS2_k127_5887159_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005041 393.0
TLS2_k127_5887159_3 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000004789 226.0
TLS2_k127_5887159_4 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000000003604 194.0
TLS2_k127_5954122_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 563.0
TLS2_k127_5954122_1 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 476.0
TLS2_k127_5954122_10 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000001128 216.0
TLS2_k127_5954122_11 PFAM Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000001395 146.0
TLS2_k127_5954122_12 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000003143 128.0
TLS2_k127_5954122_13 Choline kinase - - - 0.0005181 51.0
TLS2_k127_5954122_2 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 466.0
TLS2_k127_5954122_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 408.0
TLS2_k127_5954122_4 Histidine kinase K07638 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007478 417.0
TLS2_k127_5954122_5 zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 336.0
TLS2_k127_5954122_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07659 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 291.0
TLS2_k127_5954122_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 295.0
TLS2_k127_5954122_8 Putative FMN-binding domain K07734 - - 0.0000000000000000000000000000000000000000000000000000000000000004507 226.0
TLS2_k127_5954122_9 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000001925 228.0
TLS2_k127_5998635_0 Penicillin amidase K01434 - 3.5.1.11 7.267e-259 819.0
TLS2_k127_5998635_1 GH3 auxin-responsive promoter - - - 7.418e-196 627.0
TLS2_k127_5998635_10 Response regulator receiver - - - 0.000000000000000000000001378 109.0
TLS2_k127_5998635_11 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000007155 90.0
TLS2_k127_5998635_13 - - - - 0.00002552 51.0
TLS2_k127_5998635_2 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 483.0
TLS2_k127_5998635_3 PFAM Sodium sulphate symporter K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 470.0
TLS2_k127_5998635_4 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 329.0
TLS2_k127_5998635_5 pyridoxamine 5'-phosphate K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 307.0
TLS2_k127_5998635_6 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 310.0
TLS2_k127_5998635_7 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007576 277.0
TLS2_k127_5998635_8 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000009758 234.0
TLS2_k127_5998635_9 response regulator - - - 0.00000000000000000000000000005865 126.0
TLS2_k127_6014584_0 Vitamin K epoxide reductase family - - - 0.0 1018.0
TLS2_k127_6014584_1 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 542.0
TLS2_k127_6014584_10 COG1544 Ribosome-associated protein Y (PSrp-1) - - - 0.00000000000000000000000000000000000000000000000000000003337 202.0
TLS2_k127_6014584_11 Uncharacterized conserved protein (DUF2267) - - - 0.000000000000000000000000000000000000000002021 171.0
TLS2_k127_6014584_12 MgtC family K07507 - - 0.0000000000000000000000000000000000000509 147.0
TLS2_k127_6014584_13 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000005928 96.0
TLS2_k127_6014584_14 - - - - 0.000000000001237 74.0
TLS2_k127_6014584_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004836 493.0
TLS2_k127_6014584_3 PFAM Glucose Sorbosone dehydrogenase K00117,K21430 - 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 492.0
TLS2_k127_6014584_4 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 487.0
TLS2_k127_6014584_5 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 425.0
TLS2_k127_6014584_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000535 273.0
TLS2_k127_6014584_7 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005649 247.0
TLS2_k127_6014584_8 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000004504 241.0
TLS2_k127_6014584_9 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000003323 226.0
TLS2_k127_601964_0 Rhodanese Homology Domain K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 498.0
TLS2_k127_601964_1 hydrolase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008148 419.0
TLS2_k127_601964_10 Evidence 4 Homologs of previously reported genes of K21440 - - 0.00000000000000007856 91.0
TLS2_k127_601964_11 Glycosyl transferase, family 2 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000067 83.0
TLS2_k127_601964_12 Protein tyrosine kinase K11912,K12132 - 2.7.11.1 0.0007773 51.0
TLS2_k127_601964_2 Acetoacetate decarboxylase (ADC) K01574 - 4.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 365.0
TLS2_k127_601964_3 KR domain K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009181 330.0
TLS2_k127_601964_4 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 289.0
TLS2_k127_601964_5 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000001823 246.0
TLS2_k127_601964_6 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000003387 232.0
TLS2_k127_601964_7 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000003203 202.0
TLS2_k127_601964_8 Belongs to the peptidase M50B family K06402 - - 0.000000000000000000000000000000000000000005895 160.0
TLS2_k127_601964_9 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000009896 150.0
TLS2_k127_6126961_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.388e-313 974.0
TLS2_k127_6126961_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.837e-291 917.0
TLS2_k127_6126961_10 E COG0620 Methionine synthase II (cobalamin-independent) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 397.0
TLS2_k127_6126961_11 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000587 374.0
TLS2_k127_6126961_12 Adenylate guanylate cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 389.0
TLS2_k127_6126961_13 Gluconolactonase K01053,K14274 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 374.0
TLS2_k127_6126961_14 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003577 337.0
TLS2_k127_6126961_15 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 334.0
TLS2_k127_6126961_16 SMART metal-dependent phosphohydrolase, HD K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 344.0
TLS2_k127_6126961_17 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 296.0
TLS2_k127_6126961_18 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001156 285.0
TLS2_k127_6126961_19 COG4177 ABC-type branched-chain amino acid transport system, permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000028 284.0
TLS2_k127_6126961_2 NusA-like KH domain K02600 - - 7.826e-226 719.0
TLS2_k127_6126961_20 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001408 276.0
TLS2_k127_6126961_21 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000001472 265.0
TLS2_k127_6126961_22 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002075 261.0
TLS2_k127_6126961_23 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005499 269.0
TLS2_k127_6126961_24 COG1253 Hemolysins and related proteins containing CBS domains K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001083 261.0
TLS2_k127_6126961_25 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000278 245.0
TLS2_k127_6126961_26 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000004529 208.0
TLS2_k127_6126961_27 Belongs to the Fur family K09826 - - 0.000000000000000000000000000000000000000000000000000000113 199.0
TLS2_k127_6126961_28 transcriptional - - - 0.000000000000000000000000000000000000000000000000000009683 197.0
TLS2_k127_6126961_29 ROS/MUCR transcriptional regulator protein - - - 0.0000000000000000000000000000000000000000000000000001364 189.0
TLS2_k127_6126961_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.902e-201 634.0
TLS2_k127_6126961_30 nucleic-acid-binding protein implicated in transcription termination K07742 - - 0.00000000000000000000000000000000000000000000001259 181.0
TLS2_k127_6126961_31 Transcriptional regulator IclR - - - 0.00000000000000000000000000000000000000000000003042 188.0
TLS2_k127_6126961_32 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000000000006844 171.0
TLS2_k127_6126961_33 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000008738 146.0
TLS2_k127_6126961_34 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000009202 142.0
TLS2_k127_6126961_35 Acetyltransferase (GNAT) domain K03824 - - 0.0000000000000000000000000000000003577 139.0
TLS2_k127_6126961_36 FR47-like protein K03789 - 2.3.1.128 0.000000000000000000000000000008876 126.0
TLS2_k127_6126961_37 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000003006 119.0
TLS2_k127_6126961_38 Tautomerase enzyme K01821 - 5.3.2.6 0.000000000000000000000002205 104.0
TLS2_k127_6126961_39 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000001192 80.0
TLS2_k127_6126961_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.221e-198 636.0
TLS2_k127_6126961_40 Tetratricopeptide repeat - - - 0.0000000000844 71.0
TLS2_k127_6126961_5 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 599.0
TLS2_k127_6126961_6 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 594.0
TLS2_k127_6126961_7 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 552.0
TLS2_k127_6126961_8 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008244 415.0
TLS2_k127_6126961_9 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 412.0
TLS2_k127_6189391_0 COG2873 O-acetylhomoserine sulfhydrylase - - - 3.558e-220 690.0
TLS2_k127_6189391_1 ABC-type multidrug transport system, ATPase and permease K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 386.0
TLS2_k127_6189391_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 297.0
TLS2_k127_6189391_3 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.000000000000000000000000000000000000000000004912 167.0
TLS2_k127_6189391_4 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000009062 123.0
TLS2_k127_6189391_5 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000001438 107.0
TLS2_k127_6189391_6 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000003732 112.0
TLS2_k127_6189391_7 Protein of unknown function (DUF1465) K13592 - - 0.00000000000000000000183 99.0
TLS2_k127_6234849_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0 1076.0
TLS2_k127_6234849_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 598.0
TLS2_k127_6234849_10 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004781 286.0
TLS2_k127_6234849_11 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001525 264.0
TLS2_k127_6234849_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001953 255.0
TLS2_k127_6234849_13 FlgJ-related protein K03796 - - 0.000000000000000000000000000000000000000000000000000000002977 215.0
TLS2_k127_6234849_14 Universal stress protein family - - - 0.000000000000000000000000000000000000000302 164.0
TLS2_k127_6234849_15 COG1214 Inactive homolog of metal-dependent proteases K14742 - - 0.0000000000000000000000000000002557 130.0
TLS2_k127_6234849_16 - - - - 0.0000000001842 70.0
TLS2_k127_6234849_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 505.0
TLS2_k127_6234849_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 489.0
TLS2_k127_6234849_4 Histidine kinase-like ATPases K14980 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 485.0
TLS2_k127_6234849_5 xylanase chitin deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 368.0
TLS2_k127_6234849_6 Uncharacterized protein conserved in bacteria (DUF2333) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 366.0
TLS2_k127_6234849_7 short-chain dehydrogenase reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 350.0
TLS2_k127_6234849_8 Transcriptional regulatory protein, C terminal K14981 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004735 306.0
TLS2_k127_6234849_9 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 303.0
TLS2_k127_6237821_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.192e-256 795.0
TLS2_k127_6237821_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002395 401.0
TLS2_k127_6237821_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 347.0
TLS2_k127_6237821_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000002256 130.0
TLS2_k127_6237821_4 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000007338 111.0
TLS2_k127_6270599_0 Chemotaxis MotB protein K02557 - - 0.00000000000000000000000000000000000000000000000001046 190.0
TLS2_k127_6270599_1 - - - - 0.00000000000000000000000000000000000000000001207 183.0
TLS2_k127_6270599_2 PFAM MgtE intracellular - - - 0.0000000000000000000000000000000000004515 145.0
TLS2_k127_6270599_3 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000002098 131.0
TLS2_k127_6270599_4 chlorophyll binding - - - 0.000000000002834 76.0
TLS2_k127_6270599_5 response to copper ion - - - 0.000000001032 64.0
TLS2_k127_6310631_0 CHASE2 K01768 - 4.6.1.1 2.899e-200 654.0
TLS2_k127_6310631_1 COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 555.0
TLS2_k127_6310631_2 HlyD family secretion protein K12542 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 374.0
TLS2_k127_6310631_3 Caspase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001564 261.0
TLS2_k127_6310631_4 Lipid A 3-O-deacylase (PagL) - - - 0.00000000000000000000000000000000000000000005834 181.0
TLS2_k127_6310631_5 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000000002527 111.0
TLS2_k127_6310631_6 peptidase C14 caspase catalytic subunit p20 - - - 0.00005111 55.0
TLS2_k127_6339172_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1759.0
TLS2_k127_6339172_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.825e-305 952.0
TLS2_k127_6339172_10 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005288 297.0
TLS2_k127_6339172_11 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000005237 267.0
TLS2_k127_6339172_12 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000007496 259.0
TLS2_k127_6339172_13 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000004804 231.0
TLS2_k127_6339172_14 COG0593 ATPase involved in DNA replication initiation - - - 0.00000000000000000000000000000000000000000000000000000000000002682 238.0
TLS2_k127_6339172_15 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.00000000000000000000000000000000000000000000000000000000000003431 240.0
TLS2_k127_6339172_16 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.00000000000000000000000000000000000000000000000000003767 211.0
TLS2_k127_6339172_17 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000002357 166.0
TLS2_k127_6339172_18 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.0000000000000000000000000000000000000000002991 161.0
TLS2_k127_6339172_19 CDP-alcohol phosphatidyltransferase K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000004139 155.0
TLS2_k127_6339172_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 2.498e-273 852.0
TLS2_k127_6339172_20 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000000000000000000000000000002647 134.0
TLS2_k127_6339172_3 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06158 - - 1.053e-201 639.0
TLS2_k127_6339172_4 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006501 450.0
TLS2_k127_6339172_5 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 471.0
TLS2_k127_6339172_6 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 432.0
TLS2_k127_6339172_7 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 410.0
TLS2_k127_6339172_8 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 366.0
TLS2_k127_6339172_9 PFAM short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 359.0
TLS2_k127_644065_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0 1047.0
TLS2_k127_644065_1 Glutathione S-transferase, C-terminal domain K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 410.0
TLS2_k127_644065_10 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005384 247.0
TLS2_k127_644065_11 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000000000000000000000000000001711 215.0
TLS2_k127_644065_12 acyl-CoA transferases carnitine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000001137 205.0
TLS2_k127_644065_13 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000004174 193.0
TLS2_k127_644065_14 Phosphoglycerate mutase - - - 0.000000000000000000000000000000000000000000000000000179 201.0
TLS2_k127_644065_15 - - - - 0.00000000000000000000000478 113.0
TLS2_k127_644065_16 - - - - 0.000000000000685 74.0
TLS2_k127_644065_17 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215 - 0.00000000004396 68.0
TLS2_k127_644065_18 - - - - 0.000000001916 66.0
TLS2_k127_644065_19 COG0530 Ca2 Na antiporter K07301 - - 0.000003938 55.0
TLS2_k127_644065_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 385.0
TLS2_k127_644065_3 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008072 304.0
TLS2_k127_644065_4 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 317.0
TLS2_k127_644065_5 COG0524 Sugar kinases, ribokinase family K00874 - 2.7.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001656 289.0
TLS2_k127_644065_6 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001267 276.0
TLS2_k127_644065_7 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000002039 261.0
TLS2_k127_644065_8 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000003094 254.0
TLS2_k127_644065_9 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000005382 242.0
TLS2_k127_6460591_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.292e-288 899.0
TLS2_k127_6460591_1 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685 - 4.2.1.7 1.2e-226 715.0
TLS2_k127_6460591_10 MaoC like domain - - - 0.00000000000000000000000000000000001852 142.0
TLS2_k127_6460591_11 Protein of unknown function (DUF3303) - - - 0.0000000000000000000000000000005454 128.0
TLS2_k127_6460591_12 SnoaL-like domain - - - 0.00000000000000000000000005784 113.0
TLS2_k127_6460591_13 TRANSCRIPTIONAL REGULATOR LuxR family - - - 0.0000000000000000000000003164 119.0
TLS2_k127_6460591_14 iron ion homeostasis - - - 0.000000000000000000000001017 114.0
TLS2_k127_6460591_15 PFAM FecR protein - - - 0.000000007645 69.0
TLS2_k127_6460591_2 Phospholipase D Active site motif K01115 - 3.1.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 426.0
TLS2_k127_6460591_3 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006719 370.0
TLS2_k127_6460591_4 CYTH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 351.0
TLS2_k127_6460591_5 PFAM Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006672 279.0
TLS2_k127_6460591_6 CHASE2 K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000004852 285.0
TLS2_k127_6460591_7 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000000000000000000000000000000008342 192.0
TLS2_k127_6460591_8 involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000001505 186.0
TLS2_k127_6460591_9 PAS domain - - - 0.0000000000000000000000000000000000001221 148.0
TLS2_k127_6468613_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003769 580.0
TLS2_k127_6468613_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 350.0
TLS2_k127_6468613_2 Protein required for attachment to host cells - - - 0.000000000000000000000000000000000000000000000000001952 196.0
TLS2_k127_6468613_3 Domain of unknown function (DUF1330) - - - 0.0002688 47.0
TLS2_k127_6477273_0 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 1.116e-260 817.0
TLS2_k127_6477273_1 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 576.0
TLS2_k127_6477273_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006977 336.0
TLS2_k127_6477273_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009677 330.0
TLS2_k127_6477273_4 - - - - 0.0000000000000000000000000000000000000000000000000001518 196.0
TLS2_k127_6477273_5 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000005164 150.0
TLS2_k127_6477273_6 Nucleotidyltransferase domain K07075 - - 0.0000000000000000003659 90.0
TLS2_k127_6477273_8 PIN domain K07063 - - 0.0004082 44.0
TLS2_k127_6491867_0 Belongs to the glutamine synthetase family K01915 - 6.3.1.2 1.519e-197 633.0
TLS2_k127_6491867_1 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009909 557.0
TLS2_k127_6491867_2 Encapsulating protein for peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 301.0
TLS2_k127_6491867_3 PFAM NnrUfamily protein - - - 0.00000000000000000000000000000000000000000000000000000000000105 219.0
TLS2_k127_6491867_4 Evidence 4 Homologs of previously reported genes of K09700 - - 0.000000000000000000000000000000000001314 141.0
TLS2_k127_6491867_5 PAS domain - - - 0.00000000000000000000002146 106.0
TLS2_k127_6491867_7 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000004024 52.0
TLS2_k127_6517836_0 COG0004 Ammonia permease K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006356 610.0
TLS2_k127_6517836_1 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 476.0
TLS2_k127_6517836_10 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 0.0000000000000000000000000000002028 132.0
TLS2_k127_6517836_11 - - - - 0.000000001604 70.0
TLS2_k127_6517836_12 - - - - 0.000001511 62.0
TLS2_k127_6517836_2 COG0436 Aspartate tyrosine aromatic aminotransferase K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 474.0
TLS2_k127_6517836_3 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 498.0
TLS2_k127_6517836_4 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 342.0
TLS2_k127_6517836_5 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.000000000000000000000000000000000000000000000000000000000000000000001985 249.0
TLS2_k127_6517836_6 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000001833 211.0
TLS2_k127_6517836_7 Belongs to the P(II) protein family K04751,K04752 - - 0.0000000000000000000000000000000000000000000000000002196 187.0
TLS2_k127_6517836_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000007039 157.0
TLS2_k127_6517836_9 Sodium/hydrogen exchanger family K03316 - - 0.0000000000000000000000000000000001876 134.0
TLS2_k127_6554612_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 2223.0
TLS2_k127_6554612_1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 2.182e-235 735.0
TLS2_k127_6554612_10 COG0859 ADP-heptose LPS heptosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004771 298.0
TLS2_k127_6554612_11 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000001263 249.0
TLS2_k127_6554612_12 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000001079 216.0
TLS2_k127_6554612_13 helix_turn_helix, mercury resistance K13639 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000006553 177.0
TLS2_k127_6554612_14 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000001107 164.0
TLS2_k127_6554612_15 PIN domain - - - 0.000000000000000000000000000006836 123.0
TLS2_k127_6554612_16 SpoVT / AbrB like domain - - - 0.0000000000000000001012 90.0
TLS2_k127_6554612_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 484.0
TLS2_k127_6554612_3 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 393.0
TLS2_k127_6554612_4 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 354.0
TLS2_k127_6554612_5 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 335.0
TLS2_k127_6554612_6 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 316.0
TLS2_k127_6554612_7 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 285.0
TLS2_k127_6554612_8 Cation efflux family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005555 281.0
TLS2_k127_6554612_9 protein conserved in bacteria K09990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000108 280.0
TLS2_k127_6579267_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 1.46e-213 678.0
TLS2_k127_6579267_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 541.0
TLS2_k127_6579267_2 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 537.0
TLS2_k127_6579267_3 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 476.0
TLS2_k127_6579267_4 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 423.0
TLS2_k127_6579267_5 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000001366 229.0
TLS2_k127_6579267_6 COG4942 Membrane-bound metallopeptidase - - - 0.000000000000000000000000000000000000000000000002053 191.0
TLS2_k127_6579267_7 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000006691 163.0
TLS2_k127_6579267_8 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000007293 148.0
TLS2_k127_6584033_0 PFAM Prolyl oligopeptidase family - - - 5.799e-218 731.0
TLS2_k127_6584033_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 5.966e-210 669.0
TLS2_k127_6584033_10 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007718 234.0
TLS2_k127_6584033_11 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000001752 174.0
TLS2_k127_6584033_12 Acetyltransferase (GNAT) domain - - - 0.00000000001836 68.0
TLS2_k127_6584033_2 Acetamidase/Formamidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 435.0
TLS2_k127_6584033_3 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 409.0
TLS2_k127_6584033_4 Sugar (and other) transporter K07552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 388.0
TLS2_k127_6584033_5 HMGL-like K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 383.0
TLS2_k127_6584033_6 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 290.0
TLS2_k127_6584033_7 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000006191 265.0
TLS2_k127_6584033_8 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001448 263.0
TLS2_k127_6584033_9 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002962 246.0
TLS2_k127_6587199_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.88e-206 659.0
TLS2_k127_6587199_1 carboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 551.0
TLS2_k127_6587199_10 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008259 308.0
TLS2_k127_6587199_11 AMP-binding enzyme C-terminal domain K18687 - 6.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008488 312.0
TLS2_k127_6587199_12 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 302.0
TLS2_k127_6587199_13 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 302.0
TLS2_k127_6587199_14 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004811 279.0
TLS2_k127_6587199_15 Acyl-CoA dehydrogenase, C-terminal domain K16047 - 1.14.14.12 0.00000000000000000000000000000000000000000000000000000000000000000000008678 256.0
TLS2_k127_6587199_16 Luciferase-like monooxygenase K17228 - 1.14.14.35 0.0000000000000000000000000000000000000000000000000000000003794 224.0
TLS2_k127_6587199_17 Luciferase-like monooxygenase K17228 - 1.14.14.35 0.0000000000000000000000000000000000000000000000000000000008513 220.0
TLS2_k127_6587199_18 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000000000000000000000002069 213.0
TLS2_k127_6587199_19 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.0000000000000000000000000000000000000000000000000000005172 212.0
TLS2_k127_6587199_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 520.0
TLS2_k127_6587199_20 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000001069 205.0
TLS2_k127_6587199_21 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) K00059,K19550 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000001854 199.0
TLS2_k127_6587199_22 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000632 190.0
TLS2_k127_6587199_23 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.00000000000000000000000000000000000000000000009753 172.0
TLS2_k127_6587199_24 Uncharacterized conserved protein (DUF2267) - - - 0.000000000000000000000000000000000000000000001014 169.0
TLS2_k127_6587199_25 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000229 164.0
TLS2_k127_6587199_26 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000002926 172.0
TLS2_k127_6587199_27 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000000000000000001391 173.0
TLS2_k127_6587199_28 Etoposide-induced protein 2.4 (EI24) - - - 0.0000000000000000000000000000000000000000003192 166.0
TLS2_k127_6587199_29 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000000000009027 151.0
TLS2_k127_6587199_3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K17228 - 1.14.14.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 493.0
TLS2_k127_6587199_30 Response regulator receiver - - - 0.000000000000000000000000000000000001978 152.0
TLS2_k127_6587199_31 Histidine phosphatase superfamily (branch 1) K08296 - - 0.000000000000000000000000000000000008966 152.0
TLS2_k127_6587199_32 - - - - 0.00000000000000000000000000000000001077 145.0
TLS2_k127_6587199_33 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000222 144.0
TLS2_k127_6587199_34 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000001409 128.0
TLS2_k127_6587199_35 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.00000000000000000000000002058 121.0
TLS2_k127_6587199_36 - - - - 0.00000000000000000000000004986 115.0
TLS2_k127_6587199_37 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000003795 102.0
TLS2_k127_6587199_38 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000008574 72.0
TLS2_k127_6587199_39 Cytochrome c - - - 0.0000000000001324 82.0
TLS2_k127_6587199_4 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 482.0
TLS2_k127_6587199_40 Bacterial extracellular solute-binding protein, family 7 K21395 - - 0.000000000129 73.0
TLS2_k127_6587199_41 Protein of unknown function (DUF2628) - - - 0.0000000153 67.0
TLS2_k127_6587199_42 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.000008878 56.0
TLS2_k127_6587199_5 Luciferase-like monooxygenase K17228 - 1.14.14.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 471.0
TLS2_k127_6587199_6 COG0524 Sugar kinases, ribokinase family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 419.0
TLS2_k127_6587199_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 395.0
TLS2_k127_6587199_8 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 371.0
TLS2_k127_6587199_9 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 332.0
TLS2_k127_6596630_0 Multicopper oxidase - - - 2.491e-286 897.0
TLS2_k127_6596630_1 Sodium/hydrogen exchanger family - - - 7.258e-226 713.0
TLS2_k127_6596630_2 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 607.0
TLS2_k127_6596630_3 Cation transport ATPase (P-type) K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007222 422.0
TLS2_k127_6596630_4 Copper resistance protein B precursor (CopB) K07233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 322.0
TLS2_k127_6596630_5 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002522 238.0
TLS2_k127_6596630_6 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000005396 173.0
TLS2_k127_6596630_7 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000000007275 89.0
TLS2_k127_6597620_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 519.0
TLS2_k127_6597620_1 Protein of unknown function (DUF445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000366 379.0
TLS2_k127_6597620_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005792 284.0
TLS2_k127_6597620_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000003142 206.0
TLS2_k127_6597620_4 Protein of unknown function (DUF3775) - - - 0.0000000000000000000000000003383 128.0
TLS2_k127_6606134_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1058.0
TLS2_k127_6606134_1 ABC-type multidrug transport system, ATPase and permease K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006747 576.0
TLS2_k127_6606134_11 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000007459 53.0
TLS2_k127_6606134_2 3-deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 336.0
TLS2_k127_6606134_3 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 299.0
TLS2_k127_6606134_4 Gram-negative porin K08720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007527 266.0
TLS2_k127_6606134_5 Gram-negative porin K08720 - - 0.000000000000000000000000000000000000000000000000000000000000000000004115 248.0
TLS2_k127_6606134_6 - - - - 0.000000000000000000000000000000003075 132.0
TLS2_k127_6606134_7 Gram-negative porin K08720 - - 0.0000000000000000000000001574 111.0
TLS2_k127_6606134_8 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000001514 102.0
TLS2_k127_6613454_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 2.006e-301 939.0
TLS2_k127_6613454_1 flagellum-specific ATP synthase K02412 - 3.6.3.14 5.358e-202 636.0
TLS2_k127_6613454_10 Flagellar hook protein FlgE K02390 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 397.0
TLS2_k127_6613454_11 NnrS protein K07234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 355.0
TLS2_k127_6613454_12 MotA/TolQ/ExbB proton channel family K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 310.0
TLS2_k127_6613454_13 helix_turn_helix, cAMP Regulatory protein K21564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000136 286.0
TLS2_k127_6613454_14 Belongs to the ParA family K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000492 263.0
TLS2_k127_6613454_15 Flagellar GTP-binding protein K02404 - - 0.0000000000000000000000000000000000000000000000000000005482 205.0
TLS2_k127_6613454_16 Copper binding proteins, plastocyanin/azurin family - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000003635 184.0
TLS2_k127_6613454_17 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000000000000000000000000000000000000000012 162.0
TLS2_k127_6613454_18 Protein of unknown function (DUF1153) - - - 0.000000000000000000000000000000000001648 141.0
TLS2_k127_6613454_19 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 - - 0.000000000000000000000000000000000005823 139.0
TLS2_k127_6613454_2 Sigma-54 interaction domain K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 610.0
TLS2_k127_6613454_20 Bacterial flagellin C-terminal helical region K02397 - - 0.00000000000000000000000000000003287 146.0
TLS2_k127_6613454_21 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.0000000000000000000000000002148 124.0
TLS2_k127_6613454_22 Flagellar biosynthesis type III secretory pathway protein K02411 - - 0.00000000000000000000000002047 118.0
TLS2_k127_6613454_23 Flagellar hook-length control protein FliK K10565 - - 0.00000000000000000002978 105.0
TLS2_k127_6613454_24 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) - - - 0.0000000000000003939 82.0
TLS2_k127_6613454_25 - - - - 0.0000000006143 66.0
TLS2_k127_6613454_3 The M ring may be actively involved in energy transduction K02409 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 502.0
TLS2_k127_6613454_4 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 475.0
TLS2_k127_6613454_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 464.0
TLS2_k127_6613454_6 nitrite reductase, copper-containing K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 453.0
TLS2_k127_6613454_7 flagellar hook-associated protein K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 468.0
TLS2_k127_6613454_8 epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 409.0
TLS2_k127_6613454_9 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K13584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 399.0
TLS2_k127_6642301_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1349.0
TLS2_k127_6642301_1 serine protein kinase K07180 - - 0.0 1089.0
TLS2_k127_6642301_10 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 552.0
TLS2_k127_6642301_11 Mandelate racemase muconate lactonizing enzyme K20023 - 4.2.1.156,4.2.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 483.0
TLS2_k127_6642301_12 His Kinase A (phosphoacceptor) domain K15011 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008307 402.0
TLS2_k127_6642301_13 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 376.0
TLS2_k127_6642301_14 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 334.0
TLS2_k127_6642301_15 PFAM ABC transporter related K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 341.0
TLS2_k127_6642301_16 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 330.0
TLS2_k127_6642301_17 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 295.0
TLS2_k127_6642301_18 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001688 291.0
TLS2_k127_6642301_19 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain K15012 GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009799 263.0
TLS2_k127_6642301_2 Bacterial extracellular solute-binding protein K02027 - - 1.008e-253 788.0
TLS2_k127_6642301_20 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006487 273.0
TLS2_k127_6642301_21 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000002319 258.0
TLS2_k127_6642301_22 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000004529 192.0
TLS2_k127_6642301_23 HWE histidine kinase - - - 0.00000000000000000000000000000000000000000000001384 193.0
TLS2_k127_6642301_24 - - - - 0.0000000000000000000000000000000000000001602 164.0
TLS2_k127_6642301_25 O-antigen ligase like membrane protein - - - 0.000000000000000000000000001042 131.0
TLS2_k127_6642301_26 rRNA (guanine-N2-)-methyltransferase activity K15257 - - 0.000000000000000000000005032 111.0
TLS2_k127_6642301_27 Sulfotransferase domain - - - 0.0000000000000000000002231 112.0
TLS2_k127_6642301_28 Methyltransferase - - - 0.0000000000000305 83.0
TLS2_k127_6642301_29 -Thioesterase K01075 - 3.1.2.23 0.000000000004604 74.0
TLS2_k127_6642301_3 ATP-dependent helicase K03579 - 3.6.4.13 1.686e-230 739.0
TLS2_k127_6642301_30 - - - - 0.0000000002076 70.0
TLS2_k127_6642301_31 Protein of unknown function (DUF1194) - - - 0.000000004675 66.0
TLS2_k127_6642301_32 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00996,K03606 - 2.7.8.6 0.0000005456 59.0
TLS2_k127_6642301_4 SpoVR like protein K06415 - - 1.333e-224 707.0
TLS2_k127_6642301_5 Asparagine synthase K01953 - 6.3.5.4 9.428e-224 710.0
TLS2_k127_6642301_6 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.4 1.551e-208 662.0
TLS2_k127_6642301_7 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 579.0
TLS2_k127_6642301_8 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 574.0
TLS2_k127_6642301_9 Binding-protein-dependent transport system inner membrane component K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005463 566.0
TLS2_k127_6646250_0 Flavin-binding monooxygenase-like - - - 2.023e-285 886.0
TLS2_k127_6646250_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K15868 - 6.2.1.7 8.174e-218 687.0
TLS2_k127_6646250_10 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 331.0
TLS2_k127_6646250_11 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 304.0
TLS2_k127_6646250_12 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 297.0
TLS2_k127_6646250_13 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001057 291.0
TLS2_k127_6646250_14 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002875 296.0
TLS2_k127_6646250_15 SOS response associated peptidase (SRAP) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001318 241.0
TLS2_k127_6646250_16 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000001719 228.0
TLS2_k127_6646250_17 Protein of unknown function (DUF1194) - - - 0.000000000000000000000000000000000000000000000000000000000009775 224.0
TLS2_k127_6646250_18 tetR family - - - 0.000000000000000000000000000000000000000000000000000000002382 209.0
TLS2_k127_6646250_19 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000001084 198.0
TLS2_k127_6646250_2 Amidohydrolase family - - - 3.663e-211 671.0
TLS2_k127_6646250_20 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000003015 189.0
TLS2_k127_6646250_21 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000104 188.0
TLS2_k127_6646250_22 Hemimethylated DNA-binding protein YccV like K11940 - - 0.0000000000000000000000000000000000000000000001685 173.0
TLS2_k127_6646250_23 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.000000000000000000000000001484 115.0
TLS2_k127_6646250_24 - - - - 0.0000000000000000000246 104.0
TLS2_k127_6646250_25 alginic acid biosynthetic process - - - 0.00003354 56.0
TLS2_k127_6646250_26 Response regulator, receiver - - - 0.0000441 51.0
TLS2_k127_6646250_3 COG1960 Acyl-CoA dehydrogenases - - - 7.029e-208 655.0
TLS2_k127_6646250_4 PFAM Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 516.0
TLS2_k127_6646250_5 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005873 502.0
TLS2_k127_6646250_6 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 413.0
TLS2_k127_6646250_7 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 402.0
TLS2_k127_6646250_8 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 339.0
TLS2_k127_6646250_9 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 327.0
TLS2_k127_6647148_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 1.462e-278 865.0
TLS2_k127_6647148_1 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 3.267e-237 752.0
TLS2_k127_6647148_10 FAD dependent oxidoreductase K09471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 447.0
TLS2_k127_6647148_11 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 437.0
TLS2_k127_6647148_12 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009478 424.0
TLS2_k127_6647148_13 Amino-transferase class IV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 407.0
TLS2_k127_6647148_14 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 409.0
TLS2_k127_6647148_15 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 399.0
TLS2_k127_6647148_16 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 379.0
TLS2_k127_6647148_17 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 392.0
TLS2_k127_6647148_18 AMP-binding enzyme C-terminal domain K00666,K16876 - 6.2.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 378.0
TLS2_k127_6647148_19 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009019 358.0
TLS2_k127_6647148_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 593.0
TLS2_k127_6647148_20 CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 379.0
TLS2_k127_6647148_21 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 329.0
TLS2_k127_6647148_22 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000649 277.0
TLS2_k127_6647148_23 Transcriptional regulator K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006393 273.0
TLS2_k127_6647148_24 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002018 271.0
TLS2_k127_6647148_25 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008867 255.0
TLS2_k127_6647148_26 Protein of unknown function (DUF4197) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000203 256.0
TLS2_k127_6647148_27 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002366 259.0
TLS2_k127_6647148_28 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009531 248.0
TLS2_k127_6647148_29 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000001199 244.0
TLS2_k127_6647148_3 Pfam Sulfatase K01133 - 3.1.6.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004426 581.0
TLS2_k127_6647148_30 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000001702 228.0
TLS2_k127_6647148_31 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000000000001267 208.0
TLS2_k127_6647148_32 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000001066 172.0
TLS2_k127_6647148_33 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000006798 184.0
TLS2_k127_6647148_34 dehydratase - - - 0.0000000000000000000000000000000000000000001771 168.0
TLS2_k127_6647148_35 Histidine kinase K07646 - 2.7.13.3 0.000000000000000000000000000000000000000002127 171.0
TLS2_k127_6647148_36 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000002225 144.0
TLS2_k127_6647148_37 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.00000000000000000004934 101.0
TLS2_k127_6647148_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 569.0
TLS2_k127_6647148_5 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 562.0
TLS2_k127_6647148_6 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 513.0
TLS2_k127_6647148_7 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 488.0
TLS2_k127_6647148_8 PFAM AhpC TSA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 466.0
TLS2_k127_6647148_9 RNA polymerase sigma K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 451.0
TLS2_k127_6652661_0 FtsX-like permease family K02004 - - 6.336e-233 756.0
TLS2_k127_6652661_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 374.0
TLS2_k127_6652661_2 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 323.0
TLS2_k127_6652661_3 Tripartite ATP-independent periplasmic transporter, DctM component K11690 GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015318,GO:0015556,GO:0015711,GO:0015740,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000007495 269.0
TLS2_k127_6652661_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000006989 77.0
TLS2_k127_6652661_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0006047 49.0
TLS2_k127_6653418_0 PAS domain K00575,K13924 - 2.1.1.80,3.1.1.61 0.0 1780.0
TLS2_k127_6653418_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 3.239e-263 835.0
TLS2_k127_6653418_10 Glycosyltransferase like family 2 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 334.0
TLS2_k127_6653418_11 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 316.0
TLS2_k127_6653418_12 pfam abc K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 303.0
TLS2_k127_6653418_13 acetyltransferase, isoleucine patch superfamily K00633,K00661 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008374,GO:0008925,GO:0009987,GO:0016043,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840 2.3.1.18,2.3.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 284.0
TLS2_k127_6653418_14 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001042 300.0
TLS2_k127_6653418_15 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000001947 216.0
TLS2_k127_6653418_16 Domain of unknown function (4846) - - - 0.000000000000000000000000000000000000000000000000000000002076 210.0
TLS2_k127_6653418_17 Glycosyltransferase like family 2 K00786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000003157 195.0
TLS2_k127_6653418_18 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.000000000000000000000000000000000000000000000000001538 187.0
TLS2_k127_6653418_19 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000000000005889 181.0
TLS2_k127_6653418_2 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 565.0
TLS2_k127_6653418_20 Cysteine dioxygenase type I - - - 0.00000000000000000000000000000000000000000009827 169.0
TLS2_k127_6653418_21 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000007346 165.0
TLS2_k127_6653418_22 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.0000000000000000000000000000000000000003934 173.0
TLS2_k127_6653418_23 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000001093 141.0
TLS2_k127_6653418_24 Sulfotransferase domain - - - 0.000000000000000000000000000000007858 139.0
TLS2_k127_6653418_25 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000002496 131.0
TLS2_k127_6653418_26 GcrA cell cycle regulator K13583 - - 0.00000000000000000000000000002473 128.0
TLS2_k127_6653418_27 Nucleotidyltransferase substrate binding protein like - - - 0.000000000000000000000000001931 120.0
TLS2_k127_6653418_28 Sulfotransferase domain - - - 0.00000000000000000000000002291 120.0
TLS2_k127_6653418_29 Sulfotransferase domain - - - 0.000000000000000000000001204 115.0
TLS2_k127_6653418_3 alcohol dehydrogenase (NAD) activity K00001,K00121,K02267,K13980,K18857 GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006015 552.0
TLS2_k127_6653418_30 Methionine biosynthesis protein MetW - - - 0.0000000000000000007594 98.0
TLS2_k127_6653418_31 protein import - - - 0.000000000000000005461 97.0
TLS2_k127_6653418_32 Sulfotransferase domain - - - 0.00000000000000001838 93.0
TLS2_k127_6653418_33 DNA polymerase beta domain-containing protein - - - 0.000000000000006032 80.0
TLS2_k127_6653418_34 ABC-type polysaccharide polyol phosphate transport system, ATPase component K09691 - - 0.000000000001072 76.0
TLS2_k127_6653418_35 phosphatidate phosphatase activity K00570,K22309 - 2.1.1.17,2.1.1.344,2.1.1.71 0.000000001196 71.0
TLS2_k127_6653418_4 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 457.0
TLS2_k127_6653418_5 PFAM SMP-30 Gluconolaconase K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009821 425.0
TLS2_k127_6653418_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 407.0
TLS2_k127_6653418_7 Dehydrogenase K00285 - 1.4.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 375.0
TLS2_k127_6653418_8 transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 374.0
TLS2_k127_6653418_9 COG0235, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 347.0
TLS2_k127_6719466_0 Belongs to the GcvT family K00302 - 1.5.3.1 0.0 1057.0
TLS2_k127_6719466_1 Thiolase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 612.0
TLS2_k127_6719466_2 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 367.0
TLS2_k127_6719466_3 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 357.0
TLS2_k127_6719466_4 FAD dependent oxidoreductase K00303,K10816 - 1.4.99.5,1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000462 265.0
TLS2_k127_6719466_5 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000001168 197.0
TLS2_k127_6719466_6 Belongs to the GcvT family K00302 - 1.5.3.1 0.00000000000000000000000000000000000002592 147.0
TLS2_k127_6719466_7 Sarcosine oxidase, gamma subunit family K00305 - 1.5.3.1 0.000000000000000000000000002436 122.0
TLS2_k127_6719466_8 Biotin-requiring enzyme - - - 0.00000000000000008395 81.0
TLS2_k127_6719466_9 Protein of unknwon function (DUF3008) - - - 0.00000000000001482 85.0
TLS2_k127_6757178_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 1.681e-277 869.0
TLS2_k127_6757178_1 N-methylhydantoinase B acetone carboxylase alpha subunit K01474 - 3.5.2.14 1.325e-256 805.0
TLS2_k127_6757178_10 PAS domain K00575,K13924 - 2.1.1.80,3.1.1.61 0.0002535 46.0
TLS2_k127_6757178_2 COG0025 NhaP-type Na H and K H antiporters - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004299 552.0
TLS2_k127_6757178_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 425.0
TLS2_k127_6757178_4 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 377.0
TLS2_k127_6757178_5 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000006666 204.0
TLS2_k127_6757178_6 Ureidoglycolate lyase - - - 0.00000000000000000000000000000000000009074 161.0
TLS2_k127_6757178_7 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 0.00000000000000000000000001563 109.0
TLS2_k127_6757178_8 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.0000000000000000000001897 97.0
TLS2_k127_6757178_9 response regulator - - - 0.0000000000002958 74.0
TLS2_k127_6774129_0 PFAM Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 459.0
TLS2_k127_6774129_1 COG1840 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 405.0
TLS2_k127_6774129_2 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 377.0
TLS2_k127_6774129_3 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 353.0
TLS2_k127_6774129_4 Iron-storage protein K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000004331 239.0
TLS2_k127_6774129_5 Glutathione S-transferase - - - 0.000000000000000000000000000000000000000000000000000000008186 204.0
TLS2_k127_6774129_6 Cold shock protein domain K03704 - - 0.000000000000000000000000001264 112.0
TLS2_k127_6774129_7 transcriptional regulator - - - 0.0000000007297 64.0
TLS2_k127_6774129_8 BFD-like [2Fe-2S] binding domain K02192 - - 0.00000002966 57.0
TLS2_k127_6795222_0 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 364.0
TLS2_k127_6795222_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009687 346.0
TLS2_k127_6795222_2 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001221 284.0
TLS2_k127_6795222_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000006802 210.0
TLS2_k127_6795222_4 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000001283 205.0
TLS2_k127_6795222_5 Two component transcriptional regulator, winged helix family K02483 - - 0.00000000000000000000000000000000000000000000000002116 192.0
TLS2_k127_6795222_6 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000000000000009631 157.0
TLS2_k127_6795222_7 MAPEG family - - - 0.00000000000000000009941 99.0
TLS2_k127_6795222_8 cellulose binding - - - 0.000000000000007466 78.0
TLS2_k127_6795222_9 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000459 65.0
TLS2_k127_6813654_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 6.768e-217 685.0
TLS2_k127_6813654_1 Polysaccharide biosynthesis protein K13013 - - 7.255e-197 637.0
TLS2_k127_6813654_2 NAD-specific glutamate dehydrogenase K15371 - 1.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 527.0
TLS2_k127_6813654_3 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 487.0
TLS2_k127_6813654_4 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 368.0
TLS2_k127_6813654_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 339.0
TLS2_k127_6813654_6 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 350.0
TLS2_k127_6813654_7 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase K02851,K13007 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000001016 282.0
TLS2_k127_6813654_8 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004711 254.0
TLS2_k127_6813654_9 PFAM small multidrug resistance protein K03297 - - 0.00000000000000000000000000000000000004387 145.0
TLS2_k127_6824695_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.937e-228 713.0
TLS2_k127_6824695_1 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 624.0
TLS2_k127_6824695_10 Belongs to the universal ribosomal protein uS5 family K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 295.0
TLS2_k127_6824695_11 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000195 271.0
TLS2_k127_6824695_12 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000009673 252.0
TLS2_k127_6824695_13 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000001408 231.0
TLS2_k127_6824695_14 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000001018 238.0
TLS2_k127_6824695_15 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000004405 220.0
TLS2_k127_6824695_16 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000009379 218.0
TLS2_k127_6824695_17 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000001247 215.0
TLS2_k127_6824695_18 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000009648 205.0
TLS2_k127_6824695_19 Ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000000000000000000000000005351 199.0
TLS2_k127_6824695_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 534.0
TLS2_k127_6824695_20 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000002796 194.0
TLS2_k127_6824695_21 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000443 196.0
TLS2_k127_6824695_22 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000000000002896 173.0
TLS2_k127_6824695_23 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000005619 168.0
TLS2_k127_6824695_24 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000002364 158.0
TLS2_k127_6824695_25 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000000000000000000008578 154.0
TLS2_k127_6824695_26 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000001028 147.0
TLS2_k127_6824695_27 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000001029 135.0
TLS2_k127_6824695_28 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000000000000002942 140.0
TLS2_k127_6824695_29 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000003779 123.0
TLS2_k127_6824695_3 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 458.0
TLS2_k127_6824695_30 Ribosomal L29 protein K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000001947 88.0
TLS2_k127_6824695_31 Ribosomal protein L30 K02907 - - 0.000000000000000005524 93.0
TLS2_k127_6824695_32 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000006623 65.0
TLS2_k127_6824695_33 PFAM AsmA family protein K07289,K07290 - - 0.00000129 61.0
TLS2_k127_6824695_4 Belongs to the peptidase S1C family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 454.0
TLS2_k127_6824695_5 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008888 377.0
TLS2_k127_6824695_6 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 365.0
TLS2_k127_6824695_7 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 377.0
TLS2_k127_6824695_8 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 353.0
TLS2_k127_6824695_9 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 319.0
TLS2_k127_6850854_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1341.0
TLS2_k127_6850854_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.019e-257 806.0
TLS2_k127_6850854_10 Chalcone and stilbene synthases, C-terminal domain K16167 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 375.0
TLS2_k127_6850854_11 TIGRFAM phosphonate metabolism protein PhnM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 367.0
TLS2_k127_6850854_12 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 327.0
TLS2_k127_6850854_13 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 301.0
TLS2_k127_6850854_14 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001035 264.0
TLS2_k127_6850854_15 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000003995 241.0
TLS2_k127_6850854_16 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000005821 257.0
TLS2_k127_6850854_17 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001771 240.0
TLS2_k127_6850854_18 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K16168 - - 0.00000000000000000000000000000000000000000000000000000000001171 210.0
TLS2_k127_6850854_19 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000003311 181.0
TLS2_k127_6850854_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 1.634e-257 811.0
TLS2_k127_6850854_20 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000006698 178.0
TLS2_k127_6850854_21 photoreceptor activity K07315,K20971 - 3.1.3.3 0.000000000000000000000000000000000000001067 170.0
TLS2_k127_6850854_22 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000001301 143.0
TLS2_k127_6850854_23 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family - - - 0.00000000000000000000000000000000001501 141.0
TLS2_k127_6850854_24 Protein conserved in bacteria - - - 0.000000000000000000000000000000004508 140.0
TLS2_k127_6850854_25 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000004603 132.0
TLS2_k127_6850854_26 Flavinator of succinate dehydrogenase K09159 - - 0.0000000000000000000000002987 108.0
TLS2_k127_6850854_27 cheY-homologous receiver domain - - - 0.0000000000000000000001271 104.0
TLS2_k127_6850854_28 Zinc-binding domain of primase-helicase K06919 - - 0.000000000000000000002524 104.0
TLS2_k127_6850854_29 Sel1 repeat K07126 - - 0.00000000000004531 80.0
TLS2_k127_6850854_3 Hydantoinase/oxoprolinase - - - 4.865e-241 767.0
TLS2_k127_6850854_30 Transcriptional regulator K07733 - - 0.000000004491 63.0
TLS2_k127_6850854_31 - - - - 0.00003749 51.0
TLS2_k127_6850854_32 cheY-homologous receiver domain - - - 0.00006191 54.0
TLS2_k127_6850854_33 Domain of unknown function (DUF927) K06919 - - 0.00008068 48.0
TLS2_k127_6850854_34 Domain of unknown function (DUF927) K06919 - - 0.0002392 47.0
TLS2_k127_6850854_35 Belongs to the 'phage' integrase family - - - 0.0002535 46.0
TLS2_k127_6850854_36 Response regulator, receiver - - - 0.0008199 48.0
TLS2_k127_6850854_4 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 4.954e-238 751.0
TLS2_k127_6850854_5 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 1.488e-233 741.0
TLS2_k127_6850854_6 Hydantoinase B/oxoprolinase - - - 6.397e-231 727.0
TLS2_k127_6850854_7 TRAP transporter, 4TM 12TM fusion protein - - - 1.002e-197 638.0
TLS2_k127_6850854_8 P4 family phage plasmid primase K06919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005137 520.0
TLS2_k127_6850854_9 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007453 400.0
TLS2_k127_6852444_0 LVIVD repeat - - - 0.0 1672.0
TLS2_k127_6852444_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 6e-263 822.0
TLS2_k127_6852444_10 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 419.0
TLS2_k127_6852444_11 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 302.0
TLS2_k127_6852444_12 COG2267 Lysophospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 301.0
TLS2_k127_6852444_13 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000192 280.0
TLS2_k127_6852444_14 PFAM Uracil-DNA glycosylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001404 279.0
TLS2_k127_6852444_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001047 246.0
TLS2_k127_6852444_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003523 223.0
TLS2_k127_6852444_17 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000001053 215.0
TLS2_k127_6852444_18 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000006666 196.0
TLS2_k127_6852444_19 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000000000000000000000004315 189.0
TLS2_k127_6852444_2 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 5.401e-241 752.0
TLS2_k127_6852444_20 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000002632 193.0
TLS2_k127_6852444_21 PFAM Acetyltransferase (GNAT) family K03790 - 2.3.1.128 0.00000000000000004357 91.0
TLS2_k127_6852444_22 protein conserved in bacteria - - - 0.000000001671 71.0
TLS2_k127_6852444_23 Pfam:T4SC - - - 0.0001491 49.0
TLS2_k127_6852444_3 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 1.323e-211 670.0
TLS2_k127_6852444_4 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 588.0
TLS2_k127_6852444_5 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 534.0
TLS2_k127_6852444_6 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 538.0
TLS2_k127_6852444_7 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 470.0
TLS2_k127_6852444_8 Type II and III secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 471.0
TLS2_k127_6852444_9 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 432.0
TLS2_k127_6864812_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 2.716e-247 782.0
TLS2_k127_6864812_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 5.665e-241 752.0
TLS2_k127_6864812_10 PFAM Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.00000000000000000000000000000000000000000000000007649 193.0
TLS2_k127_6864812_11 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000007723 140.0
TLS2_k127_6864812_12 Protein conserved in bacteria - - - 0.00000000000000000000000000002601 125.0
TLS2_k127_6864812_13 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000000000000001016 123.0
TLS2_k127_6864812_14 3-beta hydroxysteroid dehydrogenase isomerase K21793 - - 0.00000000000008096 85.0
TLS2_k127_6864812_15 Sulfotransferase domain - - - 0.0007961 44.0
TLS2_k127_6864812_2 homoserine dehydrogenase K00003 - 1.1.1.3 4.856e-195 617.0
TLS2_k127_6864812_3 COG0303 Molybdopterin biosynthesis enzyme K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 486.0
TLS2_k127_6864812_4 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 321.0
TLS2_k127_6864812_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006828 319.0
TLS2_k127_6864812_6 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000158 290.0
TLS2_k127_6864812_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.000000000000000000000000000000000000000000000000000000000000005751 231.0
TLS2_k127_6864812_8 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000000000000000000000000000000000000000001049 222.0
TLS2_k127_6864812_9 COG0314 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000000001671 208.0
TLS2_k127_6911353_0 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1435.0
TLS2_k127_6911353_1 Bacterial protein of unknown function (DUF839) K07093 - - 2.42e-259 815.0
TLS2_k127_6911353_10 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 392.0
TLS2_k127_6911353_11 COG0437 Fe-S-cluster-containing hydrogenase components 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 393.0
TLS2_k127_6911353_12 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 377.0
TLS2_k127_6911353_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 382.0
TLS2_k127_6911353_14 DMSO reductase anchor subunit K21309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 346.0
TLS2_k127_6911353_15 endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 308.0
TLS2_k127_6911353_16 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 307.0
TLS2_k127_6911353_17 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 292.0
TLS2_k127_6911353_18 Phospholipase/Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003356 255.0
TLS2_k127_6911353_19 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000333 244.0
TLS2_k127_6911353_2 Carboxyl transferase domain - - - 8.493e-247 771.0
TLS2_k127_6911353_20 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001431 238.0
TLS2_k127_6911353_21 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000002328 210.0
TLS2_k127_6911353_22 endonuclease III K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000639 191.0
TLS2_k127_6911353_23 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000001179 181.0
TLS2_k127_6911353_24 - - - - 0.000000000000000000000000000000000000000000000001768 190.0
TLS2_k127_6911353_25 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000004876 171.0
TLS2_k127_6911353_26 Histidine kinase - - - 0.000000000000000000000000000000000000000000004377 180.0
TLS2_k127_6911353_27 bond formation protein, DsbB - - - 0.000000000000000000000000000000000000000000007358 169.0
TLS2_k127_6911353_28 Sel1-like repeats. K07126 - - 0.00000000000000000000000000000000000000005408 163.0
TLS2_k127_6911353_29 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.00000000000000000000000000000000162 139.0
TLS2_k127_6911353_3 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 578.0
TLS2_k127_6911353_30 lipopolysaccharide transport K04744,K09774 - - 0.000000000000000000007063 107.0
TLS2_k127_6911353_31 - - - - 0.00000000000000002384 93.0
TLS2_k127_6911353_32 resolvase domain protein - - - 0.00003726 47.0
TLS2_k127_6911353_4 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 549.0
TLS2_k127_6911353_5 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 523.0
TLS2_k127_6911353_6 fad dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 509.0
TLS2_k127_6911353_7 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 460.0
TLS2_k127_6911353_8 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 465.0
TLS2_k127_6911353_9 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 433.0
TLS2_k127_6915623_0 Adenylate and Guanylate cyclase catalytic domain - - - 2.183e-229 752.0
TLS2_k127_6915623_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006831 545.0
TLS2_k127_6915623_2 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 332.0
TLS2_k127_6915623_3 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 316.0
TLS2_k127_6915623_4 COG2931 RTX toxins and related Ca2 -binding proteins K01406,K07004 - 3.4.24.40 0.000000000000000000000000000000000000000000000000000000000000000000000000001602 280.0
TLS2_k127_6915623_5 COG0607 Rhodanese-related sulfurtransferase - - - 0.0000000000000000000000000000000000000000002306 164.0
TLS2_k127_6915623_6 - - - - 0.00000000000000000007464 92.0
TLS2_k127_6928205_0 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 595.0
TLS2_k127_6928205_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 553.0
TLS2_k127_6928205_2 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 308.0
TLS2_k127_6928205_3 NMT1/THI5 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 314.0
TLS2_k127_6928205_4 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000302 214.0
TLS2_k127_6928205_5 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000005681 193.0
TLS2_k127_6928205_6 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000001705 126.0
TLS2_k127_6940894_0 Thiamine pyrophosphate enzyme, central domain - - - 2.788e-274 854.0
TLS2_k127_6940894_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 1.471e-207 652.0
TLS2_k127_6940894_10 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000002123 245.0
TLS2_k127_6940894_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000003256 107.0
TLS2_k127_6940894_2 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein - - - 2.959e-203 646.0
TLS2_k127_6940894_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006075 557.0
TLS2_k127_6940894_4 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 325.0
TLS2_k127_6940894_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 305.0
TLS2_k127_6940894_6 protocatechuate 3,4-dioxygenase, beta subunit' K03381 - 1.13.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000001698 255.0
TLS2_k127_6940894_7 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000001084 241.0
TLS2_k127_6940894_8 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000004259 231.0
TLS2_k127_6940894_9 transport system, small permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000004228 230.0
TLS2_k127_6978759_0 COG0471 Di- and tricarboxylate transporters - - - 1.026e-236 746.0
TLS2_k127_6978759_1 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 567.0
TLS2_k127_6978759_10 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000003143 217.0
TLS2_k127_6978759_11 PIN domain - - - 0.00000000000000000000000000000000000000000000000000001154 194.0
TLS2_k127_6978759_12 RF-1 domain K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.00000000000000000000000000000000000000000000004076 174.0
TLS2_k127_6978759_13 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000002189 133.0
TLS2_k127_6978759_15 - - - - 0.0000000000000000000007129 111.0
TLS2_k127_6978759_16 - - - - 0.00000000000000000001047 93.0
TLS2_k127_6978759_17 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000002752 92.0
TLS2_k127_6978759_18 Acetyltransferase (GNAT) domain - - - 0.00000000000000003062 87.0
TLS2_k127_6978759_2 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005978 560.0
TLS2_k127_6978759_3 phosphogluconate dehydrogenase (decarboxylating) activity K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 341.0
TLS2_k127_6978759_4 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 306.0
TLS2_k127_6978759_5 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006189 302.0
TLS2_k127_6978759_6 Methyltransferase K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 304.0
TLS2_k127_6978759_7 ABC-type tungstate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 291.0
TLS2_k127_6978759_8 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000504 297.0
TLS2_k127_6978759_9 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000003282 235.0
TLS2_k127_7025726_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.96e-311 965.0
TLS2_k127_7025726_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.448e-241 755.0
TLS2_k127_7025726_10 Phenazine biosynthesis-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 317.0
TLS2_k127_7025726_11 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 308.0
TLS2_k127_7025726_12 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 303.0
TLS2_k127_7025726_13 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000002782 161.0
TLS2_k127_7025726_14 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000004385 158.0
TLS2_k127_7025726_15 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000000002618 155.0
TLS2_k127_7025726_16 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840 - 0.000000000000001863 82.0
TLS2_k127_7025726_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 613.0
TLS2_k127_7025726_3 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008488 553.0
TLS2_k127_7025726_4 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 488.0
TLS2_k127_7025726_5 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 492.0
TLS2_k127_7025726_6 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K04127,K11325,K21174 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 419.0
TLS2_k127_7025726_7 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 400.0
TLS2_k127_7025726_8 Protein of unknown function (DUF3095) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 370.0
TLS2_k127_7025726_9 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 338.0
TLS2_k127_7040632_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 7.757e-213 671.0
TLS2_k127_7040632_1 Ring hydroxylating alpha subunit (catalytic domain) K16319,K18074 - 1.14.12.1,1.14.12.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007008 519.0
TLS2_k127_7040632_10 rpsU-divergently transcribed protein K18587 - - 0.000000000000000000000000000000000000000000000000000000001833 211.0
TLS2_k127_7040632_11 Ring hydroxylating beta subunit K18075 - 1.14.12.15 0.000000000000000000000000000000000000000000442 168.0
TLS2_k127_7040632_12 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.00000000000000000000000000000000000001059 146.0
TLS2_k127_7040632_2 Alanine dehydrogenase/PNT, C-terminal domain K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 458.0
TLS2_k127_7040632_3 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 382.0
TLS2_k127_7040632_4 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000811 317.0
TLS2_k127_7040632_5 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000005268 258.0
TLS2_k127_7040632_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000003677 248.0
TLS2_k127_7040632_7 Diguanylate cyclase, GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008578 239.0
TLS2_k127_7040632_8 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000003407 230.0
TLS2_k127_7040632_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000008564 231.0
TLS2_k127_7128752_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 589.0
TLS2_k127_7128752_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 546.0
TLS2_k127_7128752_10 COG1530 Ribonucleases G and E K08300,K08301 - 3.1.26.12 0.0004205 51.0
TLS2_k127_7128752_2 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 435.0
TLS2_k127_7128752_3 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 337.0
TLS2_k127_7128752_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 307.0
TLS2_k127_7128752_5 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003477 251.0
TLS2_k127_7128752_6 Uncharacterised protein family (UPF0262) - - - 0.000000000000000000000000000000000000000000000000000000000001337 214.0
TLS2_k127_7128752_7 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.0000000000000000000000000000000000000000000000000000002442 200.0
TLS2_k127_7128752_8 Protein of unknown function (DUF2948) - - - 0.00000000000000000000000001705 116.0
TLS2_k127_7128752_9 PAS domain - - - 0.0000000000000000008554 96.0
TLS2_k127_7149391_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1124.0
TLS2_k127_7149391_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 9.516e-203 633.0
TLS2_k127_7149391_10 Methyltransferase type 12 - - - 0.00000006157 55.0
TLS2_k127_7149391_11 Adenylate cyclase - - - 0.00004129 50.0
TLS2_k127_7149391_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 555.0
TLS2_k127_7149391_3 Malonyl-CoA decarboxylase N-terminal domain K01578 - 4.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 538.0
TLS2_k127_7149391_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 504.0
TLS2_k127_7149391_5 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 484.0
TLS2_k127_7149391_6 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008159 345.0
TLS2_k127_7149391_7 Methyltransferase type 12 - - - 0.00000000000000000000000000000000000000000000000000000000000000000005997 237.0
TLS2_k127_7149391_8 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000001535 145.0
TLS2_k127_7149391_9 COGs COG0790 FOG TPR repeat SEL1 subfamily - - - 0.00000000000000000000000000006093 123.0
TLS2_k127_7199486_0 Cytochrome C and Quinol oxidase polypeptide I K02274,K15408 - 1.9.3.1 0.0 1187.0
TLS2_k127_7199486_1 Peptidase dimerisation domain K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 463.0
TLS2_k127_7199486_10 - - - - 0.000000004354 64.0
TLS2_k127_7199486_12 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.0000044 55.0
TLS2_k127_7199486_13 Bacterial protein of unknown function (DUF883) - - - 0.0002456 48.0
TLS2_k127_7199486_2 ubiquinol oxidase subunit K02297 - 1.10.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 351.0
TLS2_k127_7199486_3 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007244 265.0
TLS2_k127_7199486_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000001568 244.0
TLS2_k127_7199486_5 cytochrome C oxidase K02351 - - 0.000000000000000000000000000000000000000000000000009382 192.0
TLS2_k127_7199486_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000552 152.0
TLS2_k127_7199486_7 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000000000000001054 104.0
TLS2_k127_7199486_8 - - - - 0.00000000000000000005391 94.0
TLS2_k127_7199486_9 Protein of unknown function (DUF1328) - - - 0.000000000000003514 76.0
TLS2_k127_7225407_0 aminopeptidase K01262 - 3.4.11.9 4.635e-252 790.0
TLS2_k127_7225407_1 PFAM carboxyl transferase K13778 - 6.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 333.0
TLS2_k127_7226441_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 5.895e-265 833.0
TLS2_k127_7226441_1 N-terminal half of MaoC dehydratase - - - 1.279e-216 678.0
TLS2_k127_7226441_10 Alternative locus ID K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000001147 126.0
TLS2_k127_7226441_11 carboxymethylenebutenolidase activity K01061,K22249 - 3.1.1.45,3.1.1.76 0.000000000000000000000000005043 121.0
TLS2_k127_7226441_12 COG0784 FOG CheY-like receiver - - - 0.0006108 48.0
TLS2_k127_7226441_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007686 493.0
TLS2_k127_7226441_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 457.0
TLS2_k127_7226441_4 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006811 336.0
TLS2_k127_7226441_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005193 297.0
TLS2_k127_7226441_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000002083 267.0
TLS2_k127_7226441_7 haemagglutination activity domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000007019 263.0
TLS2_k127_7226441_8 - - - - 0.000000000000000000000000000000000000000000000000000005763 194.0
TLS2_k127_7226802_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 3.568e-260 822.0
TLS2_k127_7226802_1 Sulfatase - - - 2.584e-239 754.0
TLS2_k127_7226802_10 TIGRFAM ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 304.0
TLS2_k127_7226802_11 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 291.0
TLS2_k127_7226802_12 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 289.0
TLS2_k127_7226802_13 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001029 280.0
TLS2_k127_7226802_14 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005648 281.0
TLS2_k127_7226802_15 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000001938 266.0
TLS2_k127_7226802_16 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001408 293.0
TLS2_k127_7226802_17 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000001382 259.0
TLS2_k127_7226802_18 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004381 246.0
TLS2_k127_7226802_19 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000001809 233.0
TLS2_k127_7226802_2 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 523.0
TLS2_k127_7226802_20 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000001696 236.0
TLS2_k127_7226802_21 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000003884 213.0
TLS2_k127_7226802_22 Histidine kinase K07716 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000001283 218.0
TLS2_k127_7226802_23 adenylate kinase - - - 0.0000000000000000000000000000000000000000000000003416 184.0
TLS2_k127_7226802_24 helix_turn_helix, mercury resistance K19591 - - 0.000000000000000000000000000000000000000000002793 177.0
TLS2_k127_7226802_25 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000005019 163.0
TLS2_k127_7226802_26 COG0784 FOG CheY-like receiver - - - 0.0000000000000000000000000000000000000004165 158.0
TLS2_k127_7226802_27 MaoC like domain - - - 0.000000000000000000000000000000000004582 149.0
TLS2_k127_7226802_28 Response regulator receiver - - - 0.00000000000000000000000000000168 128.0
TLS2_k127_7226802_29 - - - - 0.00000000000000000000000008402 114.0
TLS2_k127_7226802_3 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 508.0
TLS2_k127_7226802_4 Cytochrome P450 K15629 - 1.11.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 466.0
TLS2_k127_7226802_5 NADH flavin oxidoreductase NADH oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009024 450.0
TLS2_k127_7226802_6 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005337 451.0
TLS2_k127_7226802_7 Enoyl-CoA hydratase/isomerase K08299 - 4.2.1.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009347 416.0
TLS2_k127_7226802_8 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 416.0
TLS2_k127_7226802_9 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 377.0
TLS2_k127_7275618_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 5.672e-301 930.0
TLS2_k127_7275618_1 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 6.936e-241 754.0
TLS2_k127_7275618_10 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 375.0
TLS2_k127_7275618_11 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 347.0
TLS2_k127_7275618_12 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 323.0
TLS2_k127_7275618_13 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 321.0
TLS2_k127_7275618_14 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 316.0
TLS2_k127_7275618_15 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000008179 286.0
TLS2_k127_7275618_16 Methyladenine glycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001405 266.0
TLS2_k127_7275618_17 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000000000000000001956 252.0
TLS2_k127_7275618_18 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001554 254.0
TLS2_k127_7275618_19 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003721 240.0
TLS2_k127_7275618_2 glutamate--cysteine ligase K01919 - 6.3.2.2 2.552e-206 650.0
TLS2_k127_7275618_20 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001266 246.0
TLS2_k127_7275618_21 SURF1-like protein K14998 - - 0.000000000000000000000000000000000000000000000000000000000000000008334 232.0
TLS2_k127_7275618_22 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.00000000000000000000000000000000000000000000000000000000000000005307 233.0
TLS2_k127_7275618_23 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000007172 212.0
TLS2_k127_7275618_24 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000001704 186.0
TLS2_k127_7275618_25 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000003006 206.0
TLS2_k127_7275618_26 Gram-negative porin K08720 - - 0.0000000000000000000000000000000000000000000000615 178.0
TLS2_k127_7275618_28 Domain of unknown function (DUF4411) - - - 0.000000000000000000000000000000000000000000006497 168.0
TLS2_k127_7275618_29 COG0451 Nucleoside-diphosphate-sugar epimerases K00091 - 1.1.1.219 0.000000000000000000000000000000000000001119 160.0
TLS2_k127_7275618_3 Zn-dependent proteases and their inactivated homologs K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 557.0
TLS2_k127_7275618_30 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000000000000003731 157.0
TLS2_k127_7275618_31 Nad-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000002014 148.0
TLS2_k127_7275618_32 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000000000001327 141.0
TLS2_k127_7275618_33 - - - - 0.0000000000000000000002672 100.0
TLS2_k127_7275618_34 IrrE N-terminal-like domain - - - 0.000000000005642 70.0
TLS2_k127_7275618_35 Alpha/beta hydrolase family - - - 0.00000000001147 77.0
TLS2_k127_7275618_36 Evidence 5 No homology to any previously reported sequences - - - 0.0001022 49.0
TLS2_k127_7275618_4 Threonine synthase N terminus K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 529.0
TLS2_k127_7275618_5 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 494.0
TLS2_k127_7275618_6 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 454.0
TLS2_k127_7275618_7 Cytochrome c oxidase subunit III K02276 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 427.0
TLS2_k127_7275618_8 helix_turn_helix gluconate operon transcriptional repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 392.0
TLS2_k127_7275618_9 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 387.0
TLS2_k127_7337722_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.815e-245 766.0
TLS2_k127_7337722_1 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 7.344e-206 651.0
TLS2_k127_7337722_10 CreA protein K05805 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000001477 229.0
TLS2_k127_7337722_11 nuclease activity K07062 - - 0.00000000000000000000000000000000000000000008689 164.0
TLS2_k127_7337722_12 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000003075 128.0
TLS2_k127_7337722_2 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K15738 - - 1.253e-195 640.0
TLS2_k127_7337722_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 545.0
TLS2_k127_7337722_4 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 509.0
TLS2_k127_7337722_5 ABC-type transport system, periplasmic component surface lipoprotein K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 492.0
TLS2_k127_7337722_6 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00322 - 1.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 477.0
TLS2_k127_7337722_7 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 458.0
TLS2_k127_7337722_8 COG0625 Glutathione S-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 383.0
TLS2_k127_7337722_9 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000007413 234.0
TLS2_k127_740685_0 aminopeptidase N K01256 - 3.4.11.2 3.772e-316 991.0
TLS2_k127_740685_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 629.0
TLS2_k127_740685_10 Aldolase/RraA K02553 - - 0.000000000000000000000000000000000000000000000000000000000000000000002674 242.0
TLS2_k127_740685_11 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000003463 247.0
TLS2_k127_740685_12 2Fe-2S -binding domain protein K03518,K07302,K19819 - 1.2.5.3,1.3.99.16,1.5.99.4 0.0000000000000000000000000000000000000000000000000000000008775 205.0
TLS2_k127_740685_13 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM-like protein K03519,K19185 - 1.2.5.3,1.5.99.14 0.000000000000000000000000000000000000000000000000000001228 214.0
TLS2_k127_740685_14 transcriptional regulator, IclR - - - 0.000000000000000000000000000000000000000000000009821 193.0
TLS2_k127_740685_15 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000002115 170.0
TLS2_k127_740685_16 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000123 135.0
TLS2_k127_740685_17 ANTAR - - - 0.0000000000000000000002621 106.0
TLS2_k127_740685_18 Domain of unknown function (DUF4168) - - - 0.00000002113 62.0
TLS2_k127_740685_2 Acyl-CoA dehydrogenase, C-terminal domain K04117 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 520.0
TLS2_k127_740685_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 440.0
TLS2_k127_740685_4 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 419.0
TLS2_k127_740685_5 rieske 2fe-2s - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 347.0
TLS2_k127_740685_6 aminopeptidase activity K18028 - 1.13.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 324.0
TLS2_k127_740685_7 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 299.0
TLS2_k127_740685_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 291.0
TLS2_k127_740685_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001537 267.0
TLS2_k127_7436838_0 PFAM Enoyl-CoA hydratase isomerase K07516 - 1.1.1.35 1.081e-292 913.0
TLS2_k127_7436838_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 512.0
TLS2_k127_7436838_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000001271 165.0
TLS2_k127_7436838_11 DNA repair protein MmcB-like - - - 0.00000000000000000000000000000000000000002131 157.0
TLS2_k127_7436838_2 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 503.0
TLS2_k127_7436838_3 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 468.0
TLS2_k127_7436838_4 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 443.0
TLS2_k127_7436838_5 Oxidoreductase K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 394.0
TLS2_k127_7436838_6 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008852 353.0
TLS2_k127_7436838_7 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006191 261.0
TLS2_k127_7436838_8 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000003323 254.0
TLS2_k127_7436838_9 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000007111 257.0
TLS2_k127_7459249_0 NADH:flavin oxidoreductase / NADH oxidase family K09461 - 1.14.13.40 9.502e-307 968.0
TLS2_k127_7459249_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 1.573e-296 936.0
TLS2_k127_7459249_10 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 549.0
TLS2_k127_7459249_11 COG3970 Fumarylacetoacetate (FAA) hydrolase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 504.0
TLS2_k127_7459249_12 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 474.0
TLS2_k127_7459249_13 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 443.0
TLS2_k127_7459249_14 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 441.0
TLS2_k127_7459249_15 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009535 423.0
TLS2_k127_7459249_16 Cache domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005879 409.0
TLS2_k127_7459249_17 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 386.0
TLS2_k127_7459249_18 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 357.0
TLS2_k127_7459249_19 Major Facilitator Superfamily K08167 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 363.0
TLS2_k127_7459249_2 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 2.889e-273 894.0
TLS2_k127_7459249_20 D-ala D-ala ligase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 363.0
TLS2_k127_7459249_21 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 333.0
TLS2_k127_7459249_22 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006109 322.0
TLS2_k127_7459249_23 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 321.0
TLS2_k127_7459249_24 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 319.0
TLS2_k127_7459249_25 response regulator K13246 - 3.1.4.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 293.0
TLS2_k127_7459249_26 WHG domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 283.0
TLS2_k127_7459249_27 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000022 272.0
TLS2_k127_7459249_28 Asp/Glu/Hydantoin racemase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001145 262.0
TLS2_k127_7459249_29 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007463 265.0
TLS2_k127_7459249_3 PFAM AMP-dependent synthetase K01895 - 6.2.1.1 3.705e-237 751.0
TLS2_k127_7459249_30 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000008345 254.0
TLS2_k127_7459249_31 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000002273 249.0
TLS2_k127_7459249_32 PFAM Dimethylmenaquinone methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002185 236.0
TLS2_k127_7459249_33 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001096 231.0
TLS2_k127_7459249_34 Protein of unknown function (DUF2889) - - - 0.00000000000000000000000000000000000000000000000001737 184.0
TLS2_k127_7459249_35 Protein of unknown function (DUF2852) - - - 0.0000000000000000000000000000000000004122 147.0
TLS2_k127_7459249_36 PFAM Cupin 2 conserved barrel domain protein K21700 - - 0.0000000000000000000000000003722 116.0
TLS2_k127_7459249_37 COG2825 Outer membrane protein - - - 0.000000000000000000000005582 107.0
TLS2_k127_7459249_38 Sel1-like repeats. K07126 - - 0.000000008183 68.0
TLS2_k127_7459249_39 histidine kinase A domain protein - - - 0.000000008193 66.0
TLS2_k127_7459249_4 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 595.0
TLS2_k127_7459249_5 lysine 2,3-aminomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 581.0
TLS2_k127_7459249_6 GAF domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 591.0
TLS2_k127_7459249_7 Aldo/keto reductase family K05882 - 1.1.1.91 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 551.0
TLS2_k127_7459249_8 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 537.0
TLS2_k127_7459249_9 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 551.0
TLS2_k127_7463994_0 Precorrin-3B K05934,K13541 - 2.1.1.131,3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 553.0
TLS2_k127_7463994_1 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007787 427.0
TLS2_k127_7463994_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 353.0
TLS2_k127_7463994_3 Precorrin-6y C5,15-methyltransferase K00595 - 2.1.1.132 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 295.0
TLS2_k127_7463994_4 Precorrin-2 K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 293.0
TLS2_k127_7463994_5 Acetyl xylan esterase (AXE1) K06889,K07397 - - 0.00000000000000000000000000000000000000000000000000000000000000000008716 241.0
TLS2_k127_7463994_6 Precorrin-6x reductase CbiJ/CobK K05895 - 1.3.1.106,1.3.1.54 0.0000000000000000000000000000000000000000000000000000000000000001506 233.0
TLS2_k127_7463994_7 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.00000000000000000000000000000000000000000000000000000000000001549 222.0
TLS2_k127_7463994_8 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.000000000000000000000000000000000007831 143.0
TLS2_k127_7463994_9 spore germination - - - 0.00000000000001217 89.0
TLS2_k127_81231_0 HELICc2 K03722 - 3.6.4.12 2.2e-322 1013.0
TLS2_k127_81231_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.3e-261 824.0
TLS2_k127_81231_10 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 365.0
TLS2_k127_81231_11 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 361.0
TLS2_k127_81231_12 ZIP Zinc transporter K07238 GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015086,GO:0015087,GO:0015093,GO:0015318,GO:0015684,GO:0015691,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0034755,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071421,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903874 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006557 330.0
TLS2_k127_81231_13 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 331.0
TLS2_k127_81231_14 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001505 259.0
TLS2_k127_81231_15 Protein of unknown function (DUF1194) - - - 0.0000000000000000000000000000000000000000000000000000000000000001314 229.0
TLS2_k127_81231_16 peroxiredoxin activity K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000000000000000173 214.0
TLS2_k127_81231_17 protein conserved in bacteria K09921 - - 0.00000000000000000000000000000000000000000000000000000000002129 213.0
TLS2_k127_81231_18 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000000000000000000000000000000001322 209.0
TLS2_k127_81231_19 PFAM Mo-dependent nitrogenase - - - 0.0000000000000000000000000000000000006868 146.0
TLS2_k127_81231_2 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 2.068e-238 761.0
TLS2_k127_81231_20 thioesterase - - - 0.0000000000000000000000001293 111.0
TLS2_k127_81231_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 605.0
TLS2_k127_81231_4 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007435 581.0
TLS2_k127_81231_5 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008313 550.0
TLS2_k127_81231_6 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009259 546.0
TLS2_k127_81231_7 cobalamin synthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 451.0
TLS2_k127_81231_8 C-terminal domain of 1-Cys peroxiredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 384.0
TLS2_k127_81231_9 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 376.0
TLS2_k127_814020_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1187.0
TLS2_k127_814020_1 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 3.865e-264 830.0
TLS2_k127_814020_10 oxidase, subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 468.0
TLS2_k127_814020_11 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 446.0
TLS2_k127_814020_12 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 444.0
TLS2_k127_814020_13 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003435 439.0
TLS2_k127_814020_14 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 443.0
TLS2_k127_814020_15 PFAM AMP-dependent synthetase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 442.0
TLS2_k127_814020_16 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 409.0
TLS2_k127_814020_17 Belongs to the beta-ketoacyl-ACP synthases family K05551,K09458 - 2.3.1.179,2.3.1.235,2.3.1.260 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 402.0
TLS2_k127_814020_18 citrate synthase K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 386.0
TLS2_k127_814020_19 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 399.0
TLS2_k127_814020_2 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 2.456e-246 778.0
TLS2_k127_814020_20 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 382.0
TLS2_k127_814020_21 o-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001199 280.0
TLS2_k127_814020_22 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000002913 265.0
TLS2_k127_814020_23 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001161 267.0
TLS2_k127_814020_24 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004872 248.0
TLS2_k127_814020_25 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008533 248.0
TLS2_k127_814020_26 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003742 238.0
TLS2_k127_814020_27 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000001443 243.0
TLS2_k127_814020_28 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007303 226.0
TLS2_k127_814020_29 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000004977 213.0
TLS2_k127_814020_3 ATP dependent DNA ligase C terminal region K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.474e-219 700.0
TLS2_k127_814020_30 Rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000000000000000004984 198.0
TLS2_k127_814020_31 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000009466 199.0
TLS2_k127_814020_32 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000000000000000000000001656 190.0
TLS2_k127_814020_33 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000000002048 188.0
TLS2_k127_814020_34 Conserved hypothetical protein (Lin0512_fam) - - - 0.000000000000000000000000000000000000000000004354 168.0
TLS2_k127_814020_35 Conserved hypothetical protein (Lin0512_fam) - - - 0.00000000000000000000000000000000000000000002291 166.0
TLS2_k127_814020_36 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000001891 167.0
TLS2_k127_814020_37 PAS domain - - - 0.0000000000000000000000000000000000000885 148.0
TLS2_k127_814020_38 ABC-type transport system, permease components - - - 0.0000000000000000000000000000000000003242 149.0
TLS2_k127_814020_39 surface antigen - - - 0.000000000000000000000000000000000004142 154.0
TLS2_k127_814020_4 oxidase subunit I K00425 - 1.10.3.14 5.116e-202 639.0
TLS2_k127_814020_40 Transcriptional regulators - - - 0.00000000000000000000000000000000002024 140.0
TLS2_k127_814020_41 Protein of unknown function (DUF962) - - - 0.0000000000000000000000000000000002037 138.0
TLS2_k127_814020_42 Universal stress protein - - - 0.00000000000000000000000000000002552 138.0
TLS2_k127_814020_43 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000003639 126.0
TLS2_k127_814020_44 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain - - - 0.000000000000000001027 95.0
TLS2_k127_814020_5 AMP-binding enzyme C-terminal domain K04116 - - 1.419e-199 636.0
TLS2_k127_814020_6 COG0044 Dihydroorotase and related cyclic amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 580.0
TLS2_k127_814020_7 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005537 541.0
TLS2_k127_814020_8 Surface antigen K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 529.0
TLS2_k127_814020_9 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 558.0
TLS2_k127_840244_0 PFAM ABC transporter K02471 - - 3.311e-215 687.0
TLS2_k127_840244_1 Glycosyl hydrolases family 15 K01178 - 3.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 333.0
TLS2_k127_840244_2 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 312.0
TLS2_k127_840244_3 Belongs to the CinA family - - - 0.00000000000000000000005661 99.0
TLS2_k127_86410_0 COG1138 Cytochrome c biogenesis factor K02198 - - 4.358e-288 901.0
TLS2_k127_86410_1 FtsX-like permease family K02004 - - 9.852e-278 883.0
TLS2_k127_86410_10 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 357.0
TLS2_k127_86410_11 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 338.0
TLS2_k127_86410_12 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 319.0
TLS2_k127_86410_13 Belongs to the BI1 family K06890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 305.0
TLS2_k127_86410_14 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006764 301.0
TLS2_k127_86410_15 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004307 282.0
TLS2_k127_86410_16 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002538 272.0
TLS2_k127_86410_17 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004859 266.0
TLS2_k127_86410_18 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001569 261.0
TLS2_k127_86410_19 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000001402 240.0
TLS2_k127_86410_2 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 521.0
TLS2_k127_86410_20 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000968 240.0
TLS2_k127_86410_21 COG4235 Cytochrome c biogenesis factor K02200 - - 0.00000000000000000000000000000000000000000000000000000000000002461 239.0
TLS2_k127_86410_22 periplasmic protein thiol disulfide K02199 - - 0.000000000000000000000000000000000000000000000000000000004906 206.0
TLS2_k127_86410_23 ATP dependent DNA ligase - - - 0.00000000000000000000000000000000000000000000000000000001473 203.0
TLS2_k127_86410_24 Bacterial transcriptional repressor C-terminal - - - 0.0000000000000000000000000000000000000000000000000000003344 200.0
TLS2_k127_86410_25 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000008891 198.0
TLS2_k127_86410_26 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000000000898 186.0
TLS2_k127_86410_27 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000001248 184.0
TLS2_k127_86410_28 Isochorismatase family - - - 0.0000000000000000000000000000000000000001541 160.0
TLS2_k127_86410_29 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 GO:0000287,GO:0000966,GO:0000967,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008312,GO:0008995,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0017151,GO:0019222,GO:0019439,GO:0019899,GO:0022607,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034655,GO:0034660,GO:0042254,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043462,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0046872,GO:0048519,GO:0050789,GO:0050790,GO:0051095,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051336,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902280 3.1.26.12 0.0000000000000000000000000000000000000002946 160.0
TLS2_k127_86410_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 513.0
TLS2_k127_86410_30 subunit of a heme lyase K02200 - - 0.00000000000000000000000000000000000004602 156.0
TLS2_k127_86410_31 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000000000000000000000000000103 153.0
TLS2_k127_86410_32 YGGT family K02221 - - 0.0000000000000000000000000000000006592 132.0
TLS2_k127_86410_33 COG1846 Transcriptional regulators - - - 0.00000000000000000000000002563 116.0
TLS2_k127_86410_34 Domain of unknown function (DUF4142) K08995 - - 0.0000000000000000000000001172 117.0
TLS2_k127_86410_35 ParB-like nuclease domain - - - 0.00000000000000000000005591 112.0
TLS2_k127_86410_36 Belongs to the UPF0235 family K09131 - - 0.000000000000000003866 88.0
TLS2_k127_86410_4 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009354 475.0
TLS2_k127_86410_5 COG0665 Glycine D-amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 458.0
TLS2_k127_86410_6 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 450.0
TLS2_k127_86410_7 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 450.0
TLS2_k127_86410_8 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 436.0
TLS2_k127_86410_9 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 394.0
TLS2_k127_890584_0 PFAM Aldehyde dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 556.0
TLS2_k127_890584_1 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 450.0
TLS2_k127_890584_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 396.0
TLS2_k127_890584_3 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 368.0
TLS2_k127_890584_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000007725 253.0
TLS2_k127_890584_5 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000594 245.0
TLS2_k127_890584_6 PFAM regulatory protein GntR HTH - - - 0.00000000000000000000000000000000000000000000000000000000000000003897 231.0
TLS2_k127_92694_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1463.0
TLS2_k127_92694_1 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006137 576.0
TLS2_k127_92694_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 352.0
TLS2_k127_92694_3 rRNA (guanine-N2-)-methyltransferase activity K15257 - - 0.00000000000000000000000000000000000000000000001203 191.0
TLS2_k127_92694_4 Aspartate tyrosine aromatic aminotransferase - - - 0.00000000000000001799 86.0
TLS2_k127_92694_5 Protein of unknown function (DUF3592) - - - 0.000000000001467 79.0
TLS2_k127_949786_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 1.388e-265 854.0
TLS2_k127_949786_1 FMN-dependent dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 450.0
TLS2_k127_949786_2 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001083 261.0
TLS2_k127_949786_3 Diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001788 246.0
TLS2_k127_949786_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000003208 200.0
TLS2_k127_949786_5 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000003586 194.0
TLS2_k127_950477_0 COG0402 Cytosine deaminase and related metal-dependent hydrolases K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 593.0
TLS2_k127_950477_1 peptidase M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007762 556.0
TLS2_k127_950477_2 Belongs to the CinA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 490.0
TLS2_k127_950477_3 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 406.0
TLS2_k127_950477_4 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 330.0
TLS2_k127_950477_5 AAA domain - - - 0.0000000000006644 80.0
TLS2_k127_969093_0 ABC transporter transmembrane region - - - 0.0 1789.0
TLS2_k127_969093_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1497.0
TLS2_k127_969093_10 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 573.0
TLS2_k127_969093_11 Cobaltochelatase CobS subunit N terminal K09882 - 6.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 561.0
TLS2_k127_969093_12 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 552.0
TLS2_k127_969093_13 Domain of unknown function DUF21 K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 492.0
TLS2_k127_969093_14 COG2309 Leucyl aminopeptidase (aminopeptidase T) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 487.0
TLS2_k127_969093_15 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006081 499.0
TLS2_k127_969093_16 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 484.0
TLS2_k127_969093_17 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 463.0
TLS2_k127_969093_18 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 443.0
TLS2_k127_969093_19 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 422.0
TLS2_k127_969093_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1290.0
TLS2_k127_969093_20 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003201 413.0
TLS2_k127_969093_21 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 404.0
TLS2_k127_969093_22 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 404.0
TLS2_k127_969093_23 Prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 391.0
TLS2_k127_969093_24 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 387.0
TLS2_k127_969093_25 Carbon-nitrogen hydrolase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 364.0
TLS2_k127_969093_26 Belongs to the 'phage' integrase family. XerC subfamily K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 348.0
TLS2_k127_969093_27 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 357.0
TLS2_k127_969093_28 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 344.0
TLS2_k127_969093_29 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 336.0
TLS2_k127_969093_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1224.0
TLS2_k127_969093_30 cell division K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000979 319.0
TLS2_k127_969093_31 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 304.0
TLS2_k127_969093_32 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001325 284.0
TLS2_k127_969093_33 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002553 287.0
TLS2_k127_969093_34 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000006341 271.0
TLS2_k127_969093_35 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000221 263.0
TLS2_k127_969093_36 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000000001318 261.0
TLS2_k127_969093_37 MOSC N-terminal beta barrel domain K07140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001521 251.0
TLS2_k127_969093_38 Alpha beta hydrolase K01055 - 3.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000009563 252.0
TLS2_k127_969093_39 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000004182 236.0
TLS2_k127_969093_4 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.078e-302 955.0
TLS2_k127_969093_40 NUDIX domain K03574 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000003174 215.0
TLS2_k127_969093_41 peptidylprolyl isomerase K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000004919 218.0
TLS2_k127_969093_42 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000000000005875 215.0
TLS2_k127_969093_43 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000428 212.0
TLS2_k127_969093_44 PFAM Methyltransferase type - - - 0.0000000000000000000000000000000000000000000000000000006018 199.0
TLS2_k127_969093_45 Domain of unknown function (DUF4115) K15539 - - 0.00000000000000000000000000000000000000000000000000009684 203.0
TLS2_k127_969093_46 nuclear chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000531 199.0
TLS2_k127_969093_47 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000115 190.0
TLS2_k127_969093_48 chorismate mutase - - - 0.000000000000000000000000000000000000000000000000008775 192.0
TLS2_k127_969093_49 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000319 166.0
TLS2_k127_969093_5 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 5.412e-240 763.0
TLS2_k127_969093_50 Cell division protein K09811 - - 0.000000000000000000000000000000000000000003089 175.0
TLS2_k127_969093_51 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000000000007144 163.0
TLS2_k127_969093_52 - - - - 0.000000000000000000000000000000000000001901 167.0
TLS2_k127_969093_53 Protein of unknown function (DUF1178) - - - 0.000000000000000000000000000000000000003857 150.0
TLS2_k127_969093_54 Uncharacterized protein conserved in bacteria (DUF2125) - - - 0.0000000000000000000000000000000000002403 153.0
TLS2_k127_969093_55 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000000000000745 134.0
TLS2_k127_969093_56 BolA-like protein K05527,K22066 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.0000000000000000000000000000001006 130.0
TLS2_k127_969093_57 zinc-ribbon domain - - - 0.0000000000000000000000000000003195 132.0
TLS2_k127_969093_58 Domain of unknown function (DUF4167) - - - 0.00000000000000000000000006554 114.0
TLS2_k127_969093_59 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000000001294 91.0
TLS2_k127_969093_6 Cobalamin biosynthesis protein CobT K09883 - 6.6.1.2 8.377e-239 767.0
TLS2_k127_969093_60 Cytochrome c - - - 0.0000000000000003054 84.0
TLS2_k127_969093_61 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.00000005827 63.0
TLS2_k127_969093_63 - - - - 0.0006651 43.0
TLS2_k127_969093_7 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 2.689e-221 701.0
TLS2_k127_969093_8 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 602.0
TLS2_k127_969093_9 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 566.0
TLS2_k127_974091_0 DNA helicase K03654 - 3.6.4.12 1.712e-236 748.0
TLS2_k127_974091_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 3.437e-214 686.0
TLS2_k127_974091_10 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007436 298.0
TLS2_k127_974091_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 292.0
TLS2_k127_974091_12 Dioxygenase K00448 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000000000006272 231.0
TLS2_k127_974091_13 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000009402 183.0
TLS2_k127_974091_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000785 159.0
TLS2_k127_974091_15 Ribonuclease B OB domain K03704 - - 0.000000000000000000000000002673 115.0
TLS2_k127_974091_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.662e-205 666.0
TLS2_k127_974091_3 Luciferase-like monooxygenase - - - 9.82e-198 628.0
TLS2_k127_974091_4 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006439 478.0
TLS2_k127_974091_5 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756,K01857 - 4.3.2.2,5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006715 456.0
TLS2_k127_974091_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 451.0
TLS2_k127_974091_7 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 385.0
TLS2_k127_974091_8 Protocatechuate 3,4-dioxygenase beta subunit N terminal K00449 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 341.0
TLS2_k127_974091_9 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 332.0
TLS2_k127_990528_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 2.572e-216 686.0
TLS2_k127_990528_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 7.081e-212 681.0
TLS2_k127_990528_10 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000001857 253.0
TLS2_k127_990528_11 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000001077 225.0
TLS2_k127_990528_12 decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000000000006131 195.0
TLS2_k127_990528_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000001411 147.0
TLS2_k127_990528_14 Tripartite ATP-independent periplasmic transporter dctq component - - - 0.000000000000000000000000000693 120.0
TLS2_k127_990528_15 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000006556 98.0
TLS2_k127_990528_2 AMP-binding enzyme K02182 - 6.2.1.48 2.445e-196 625.0
TLS2_k127_990528_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 537.0
TLS2_k127_990528_4 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101,K05713 - 1.13.11.16,1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 456.0
TLS2_k127_990528_5 FAD binding domain K18071 - 1.14.12.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 404.0
TLS2_k127_990528_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 400.0
TLS2_k127_990528_7 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 369.0
TLS2_k127_990528_8 FAD binding domain K18071 - 1.14.12.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 334.0
TLS2_k127_990528_9 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 328.0