Overview

ID MAG04031
Name TLS2_bin.8
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum UBA10199
Class UBA10199
Order DSSB01
Family DSSB01
Genus DATEDP01
Species
Assembly information
Completeness (%) 98.14
Contamination (%) 0.63
GC content (%) 60.0
N50 (bp) 14,628
Genome size (bp) 2,707,116

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2009

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_100981_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000909 444.0
TLS2_k127_100981_1 Domain of unknown function (DUF4301) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 345.0
TLS2_k127_100981_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K13775 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 289.0
TLS2_k127_100981_3 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000067 192.0
TLS2_k127_1022597_0 ABC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 410.0
TLS2_k127_1022597_1 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000002188 177.0
TLS2_k127_1022597_2 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000003347 113.0
TLS2_k127_1022597_3 energy transducer activity K03646,K03832 - - 0.00009557 54.0
TLS2_k127_111602_0 PFAM magnesium chelatase K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 520.0
TLS2_k127_111602_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 373.0
TLS2_k127_111602_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000007121 185.0
TLS2_k127_111602_3 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000002409 186.0
TLS2_k127_111602_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000243 181.0
TLS2_k127_111602_5 Sensor histidine kinase, HAMP domain-containing K07644 - 2.7.13.3 0.000000000000000000003102 109.0
TLS2_k127_111602_6 Tetratricopeptide repeat - - - 0.00000003857 64.0
TLS2_k127_1122167_0 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006993 412.0
TLS2_k127_113792_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.577e-291 908.0
TLS2_k127_113792_1 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 327.0
TLS2_k127_113792_2 PFAM aminotransferase, class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007227 286.0
TLS2_k127_113792_3 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000000002537 117.0
TLS2_k127_1151744_0 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000004483 228.0
TLS2_k127_1151744_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000248 232.0
TLS2_k127_1151744_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000004911 192.0
TLS2_k127_1151744_3 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000396 178.0
TLS2_k127_1151744_4 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000007878 180.0
TLS2_k127_1151744_5 Mitochondrial small ribosomal subunit Rsm22 - - - 0.00000000000000000000000000000000000393 151.0
TLS2_k127_1152146_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.914e-258 814.0
TLS2_k127_1152146_1 PFAM Phosphoglucomutase phosphomannomutase, alpha beta alpha domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 494.0
TLS2_k127_1152146_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000938 281.0
TLS2_k127_1152146_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000002157 239.0
TLS2_k127_1152146_4 Ferrous iron transport protein B K04759 - - 0.0000000000000000000000000000000000000001199 154.0
TLS2_k127_1152146_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000001319 127.0
TLS2_k127_1152146_6 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.00000000000000000000001356 114.0
TLS2_k127_1185230_0 4Fe-4S single cluster domain K06937 - - 2.144e-259 814.0
TLS2_k127_1185230_1 Belongs to the GbsR family - - - 0.00000000000000007492 88.0
TLS2_k127_1207404_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 3.957e-250 778.0
TLS2_k127_1207404_1 ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 605.0
TLS2_k127_1207404_2 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 548.0
TLS2_k127_1207404_3 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 496.0
TLS2_k127_1207404_4 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000859 191.0
TLS2_k127_1207827_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1157.0
TLS2_k127_1207827_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 7.677e-243 763.0
TLS2_k127_1207827_10 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 462.0
TLS2_k127_1207827_11 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 442.0
TLS2_k127_1207827_12 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 415.0
TLS2_k127_1207827_13 COG0454 Histone acetyltransferase HPA2 and related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 375.0
TLS2_k127_1207827_14 TIGRFAM Potassium uptake protein TrkH K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 366.0
TLS2_k127_1207827_15 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 356.0
TLS2_k127_1207827_16 Serine Threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 379.0
TLS2_k127_1207827_17 TIGRFAM PAS sensor protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 349.0
TLS2_k127_1207827_18 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 339.0
TLS2_k127_1207827_19 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 321.0
TLS2_k127_1207827_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 1.168e-217 688.0
TLS2_k127_1207827_20 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009454 325.0
TLS2_k127_1207827_21 Metal binding domain of Ada K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 310.0
TLS2_k127_1207827_22 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity K00821,K05830,K09251 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0033094,GO:0034641,GO:0036094,GO:0042402,GO:0042802,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901575 2.6.1.11,2.6.1.17,2.6.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 300.0
TLS2_k127_1207827_23 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002752 275.0
TLS2_k127_1207827_24 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000001234 271.0
TLS2_k127_1207827_25 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006913 278.0
TLS2_k127_1207827_26 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000001253 269.0
TLS2_k127_1207827_27 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000002215 242.0
TLS2_k127_1207827_28 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000001039 245.0
TLS2_k127_1207827_29 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000002127 240.0
TLS2_k127_1207827_3 FtsX-like permease family K02004 - - 8.855e-210 683.0
TLS2_k127_1207827_30 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000003519 240.0
TLS2_k127_1207827_31 Parallel beta-helix repeats K12287 - - 0.00000000000000000000000000000000000000000000000000000000000000000009746 256.0
TLS2_k127_1207827_32 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000007801 238.0
TLS2_k127_1207827_33 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000001001 224.0
TLS2_k127_1207827_34 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000001776 218.0
TLS2_k127_1207827_35 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000005695 201.0
TLS2_k127_1207827_36 PFAM TrkA-N domain protein K03499 - - 0.0000000000000000000000000000000000000000000000000000007932 218.0
TLS2_k127_1207827_37 Cytochrome c oxidase subunit III - - - 0.000000000000000000000000000000000000000000000000000002782 197.0
TLS2_k127_1207827_38 COG0454 Histone acetyltransferase HPA2 and related - - - 0.000000000000000000000000000000000000000000000000007368 199.0
TLS2_k127_1207827_39 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000002979 186.0
TLS2_k127_1207827_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 570.0
TLS2_k127_1207827_40 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000000000000000003319 198.0
TLS2_k127_1207827_41 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000006097 181.0
TLS2_k127_1207827_42 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000004914 179.0
TLS2_k127_1207827_43 PFAM Cyclic nucleotide-binding K10914 - - 0.0000000000000000000000000000000000000000000002017 177.0
TLS2_k127_1207827_44 PFAM Response regulator receiver domain - - - 0.00000000000000000000000000000000000000001468 160.0
TLS2_k127_1207827_45 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000002835 158.0
TLS2_k127_1207827_46 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000001806 152.0
TLS2_k127_1207827_47 ATPase (AAA superfamily) K06921 - - 0.000000000000000000000000000000000000002577 161.0
TLS2_k127_1207827_48 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000001312 158.0
TLS2_k127_1207827_49 Could be involved in septation K06412 - - 0.0000000000000000000000000000000000001576 144.0
TLS2_k127_1207827_5 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 559.0
TLS2_k127_1207827_50 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001672 139.0
TLS2_k127_1207827_51 guanyl-nucleotide exchange factor activity K20276,K21449 - - 0.000000000000000000000000000000009361 143.0
TLS2_k127_1207827_52 phosphorelay sensor kinase activity K01768 - 4.6.1.1 0.00000000000000000000000000000008961 143.0
TLS2_k127_1207827_53 cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.000000000000000000000000000001166 132.0
TLS2_k127_1207827_54 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000005773 124.0
TLS2_k127_1207827_55 MAPEG family - - - 0.0000000000000000000000000001853 118.0
TLS2_k127_1207827_56 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000006593 111.0
TLS2_k127_1207827_57 Belongs to the universal stress protein A family - - - 0.00000000000000000000000003267 120.0
TLS2_k127_1207827_58 Phosphate acyltransferases - - - 0.0000000000000000000000004823 114.0
TLS2_k127_1207827_59 PFAM response regulator receiver K07657 - - 0.000000000000000000000008699 106.0
TLS2_k127_1207827_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 546.0
TLS2_k127_1207827_60 COG3075 Anaerobic glycerol-3-phosphate dehydrogenase K00112 - 1.1.5.3 0.00000000000000000000002061 116.0
TLS2_k127_1207827_61 Predicted membrane protein (DUF2232) - - - 0.00000000000000000000002853 112.0
TLS2_k127_1207827_62 Protein of unknown function (DUF4013) - - - 0.000000000000000000000645 106.0
TLS2_k127_1207827_63 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.0000000000000000000009582 95.0
TLS2_k127_1207827_64 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000001891 99.0
TLS2_k127_1207827_65 - - - - 0.0000000000008659 75.0
TLS2_k127_1207827_66 nuclease activity K06218 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000001919 70.0
TLS2_k127_1207827_67 Endonuclease Exonuclease Phosphatase K07004 - - 0.00000000003621 75.0
TLS2_k127_1207827_68 toxin-antitoxin pair type II binding K08591,K19159 GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141 2.3.1.15 0.00000000008223 66.0
TLS2_k127_1207827_7 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 535.0
TLS2_k127_1207827_70 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.0000179 51.0
TLS2_k127_1207827_71 - - - - 0.00001791 49.0
TLS2_k127_1207827_73 Phospholipase, patatin family K07001 - - 0.0001718 54.0
TLS2_k127_1207827_74 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0005702 51.0
TLS2_k127_1207827_8 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 536.0
TLS2_k127_1207827_9 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 479.0
TLS2_k127_1212675_0 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 330.0
TLS2_k127_1212675_1 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000001218 175.0
TLS2_k127_1212675_2 ABC-type phosphate phosphonate transport system periplasmic component - - - 0.00000000348 70.0
TLS2_k127_1226622_0 Glycosyl transferase family, helical bundle domain K00756,K00758 - 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004561 385.0
TLS2_k127_1226622_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - - 0.000000000000000000000000000000000000000000000000000000000000001044 241.0
TLS2_k127_1226622_2 CBS domain K03699 - - 0.0000000000000000000000000000000000000000003172 171.0
TLS2_k127_1226622_3 UspA domain-containing protein - - - 0.00003716 57.0
TLS2_k127_1284553_0 Alpha-2-Macroglobulin K06894 - - 4.689e-194 661.0
TLS2_k127_1284553_1 PFAM TonB-dependent Receptor K16091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 495.0
TLS2_k127_1284553_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000005937 196.0
TLS2_k127_1284553_3 Ferritin-like domain K03594 - 1.16.3.1 0.000000000000000000000000000000000000000006369 158.0
TLS2_k127_1284553_4 Low molecular weight phosphatase family - - - 0.000000000000000000000000000000000001782 142.0
TLS2_k127_1284553_5 VanW like protein K18346 - - 0.0000000000000000000000000000002013 130.0
TLS2_k127_1284553_6 Stage II sporulation D domain protein K06381 - - 0.000000000000000000000000000009856 129.0
TLS2_k127_1284553_7 - - - - 0.00000000000000000000009556 104.0
TLS2_k127_1284553_8 Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - 0.000000000000000000005122 108.0
TLS2_k127_1284553_9 - - - - 0.00002576 56.0
TLS2_k127_1313327_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.312e-219 723.0
TLS2_k127_1334420_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000001107 226.0
TLS2_k127_1334420_1 - - - - 0.0000000000000000000000001796 115.0
TLS2_k127_1334420_2 CsbD-like - - - 0.000000000000000000002426 94.0
TLS2_k127_1334420_3 COG0517 FOG CBS domain - - - 0.0000000000000003263 85.0
TLS2_k127_1374288_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 3.276e-197 629.0
TLS2_k127_1374288_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 338.0
TLS2_k127_1374288_2 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 308.0
TLS2_k127_1374288_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 301.0
TLS2_k127_1374288_4 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008798 252.0
TLS2_k127_1374288_5 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000001342 245.0
TLS2_k127_1374288_6 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000149 227.0
TLS2_k127_1374288_7 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000001491 154.0
TLS2_k127_1378931_0 TRCF K03723 - - 5.657e-286 917.0
TLS2_k127_1378931_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000419 282.0
TLS2_k127_1378931_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000006023 230.0
TLS2_k127_1378931_3 peptidyl-prolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000001029 153.0
TLS2_k127_1378931_4 PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain K07443 - - 0.00000000000000000000005095 103.0
TLS2_k127_1378931_5 peptidylprolyl isomerase K07533 - 5.2.1.8 0.000000004072 68.0
TLS2_k127_1381651_0 surface antigen K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000001067 246.0
TLS2_k127_1381651_1 protein secretion K09800 - - 0.000000000000000000000000000000000000000000000000005891 209.0
TLS2_k127_1414650_0 Forkhead associated domain - - - 0.0000000000000000000000000000000000003975 154.0
TLS2_k127_1414650_1 Belongs to the ompA family - - - 0.000000000000000000000007133 117.0
TLS2_k127_1414650_2 Tetratricopeptide repeat - - - 0.00000000000000000000004685 113.0
TLS2_k127_1414650_3 GGDEF domain - - - 0.00000000000464 79.0
TLS2_k127_1414650_4 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000006373 68.0
TLS2_k127_1436541_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 546.0
TLS2_k127_1436541_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 365.0
TLS2_k127_1436541_2 ABC transporter, ATP-binding protein K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 303.0
TLS2_k127_1436541_3 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000001756 242.0
TLS2_k127_1436541_4 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000003884 237.0
TLS2_k127_1436541_5 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000006677 115.0
TLS2_k127_1436541_7 Protein of unknown function (DUF1566) - - - 0.000000000156 69.0
TLS2_k127_144654_0 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008807 258.0
TLS2_k127_144654_1 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000002524 237.0
TLS2_k127_144654_2 Photosynthesis system II assembly factor YCF48 - - - 0.0000000000000000001369 99.0
TLS2_k127_144654_3 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000003378 70.0
TLS2_k127_1471219_0 Glycoprotease family K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 327.0
TLS2_k127_1471219_1 Adventurous gliding motility protein R - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 302.0
TLS2_k127_1471219_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000008689 189.0
TLS2_k127_1471219_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000148 184.0
TLS2_k127_1471219_4 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206,K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000005695 171.0
TLS2_k127_1471219_5 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000001029 135.0
TLS2_k127_1471219_6 TIGRFAM tol-pal system protein YbgF - - - 0.0000000000000004212 90.0
TLS2_k127_1471219_7 PilZ domain K02676 - - 0.000001383 55.0
TLS2_k127_1479922_0 'glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1941.0
TLS2_k127_1479922_1 Flavin containing amine oxidoreductase K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 5.495e-206 651.0
TLS2_k127_1479922_2 PFAM ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 590.0
TLS2_k127_1479922_3 4Fe-4S single cluster domain of Ferredoxin I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 340.0
TLS2_k127_1479922_4 PFAM ABC transporter related K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 288.0
TLS2_k127_1479922_5 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000002431 181.0
TLS2_k127_1479922_6 Ion channel - - - 0.0000000000000000000004854 105.0
TLS2_k127_1479922_7 PFAM thioesterase superfamily K02614 - - 0.0000000000000025 83.0
TLS2_k127_1491702_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 2.713e-195 623.0
TLS2_k127_1491702_1 PFAM Prenyltransferase squalene oxidase K01852,K06045 - 4.2.1.129,5.4.99.17,5.4.99.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 582.0
TLS2_k127_1491702_10 Protein phosphatase 2C K20074 - 3.1.3.16 0.0000949 58.0
TLS2_k127_1491702_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006857 407.0
TLS2_k127_1491702_3 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003961 395.0
TLS2_k127_1491702_4 PFAM fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001366 282.0
TLS2_k127_1491702_5 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004055 250.0
TLS2_k127_1491702_6 Hit family K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000001033 213.0
TLS2_k127_1491702_7 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000005137 182.0
TLS2_k127_1491702_8 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000001623 157.0
TLS2_k127_1491702_9 Belongs to the bacterial histone-like protein family K05788 - - 0.000000000000000000000009764 113.0
TLS2_k127_149779_0 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005036 447.0
TLS2_k127_149779_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 428.0
TLS2_k127_149779_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 415.0
TLS2_k127_149779_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 408.0
TLS2_k127_149779_4 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000171 172.0
TLS2_k127_149779_5 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000002065 182.0
TLS2_k127_149779_6 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000005346 152.0
TLS2_k127_149779_7 Cysteine-rich domain - - - 0.0000000000000000000000000000000952 143.0
TLS2_k127_149779_9 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 0.0000000005742 69.0
TLS2_k127_1515046_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 543.0
TLS2_k127_1515046_1 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 432.0
TLS2_k127_1515046_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000001386 166.0
TLS2_k127_1515046_3 cytochrome c biogenesis protein - - - 0.00000000000000000000000000000000000000002547 174.0
TLS2_k127_1515046_4 GtrA-like protein K00995 - 2.7.8.5 0.0000000000000000000000000000000000000001696 158.0
TLS2_k127_1515046_5 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000000000003097 131.0
TLS2_k127_1515046_6 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000002366 124.0
TLS2_k127_1515046_7 Restriction endonuclease K07448 - - 0.000000000000000000081 96.0
TLS2_k127_1523079_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 300.0
TLS2_k127_1523079_1 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000005769 224.0
TLS2_k127_1523079_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000001109 201.0
TLS2_k127_1525254_0 succinate dehydrogenase or fumarate reductase, flavoprotein K00239 - 1.3.5.1,1.3.5.4 1.226e-313 979.0
TLS2_k127_1525254_1 Heat shock 70 kDa protein K04043 - - 5.673e-285 889.0
TLS2_k127_1525254_10 SCP-2 sterol transfer family - - - 0.0000000000000000000000000002571 117.0
TLS2_k127_1525254_11 membrane - - - 0.00000000000000000001934 95.0
TLS2_k127_1525254_12 Protein of unknown function (DUF2752) - - - 0.000000004898 63.0
TLS2_k127_1525254_13 Psort location CytoplasmicMembrane, score - - - 0.0000001309 60.0
TLS2_k127_1525254_14 - - - - 0.0006973 45.0
TLS2_k127_1525254_2 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007898 513.0
TLS2_k127_1525254_3 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 413.0
TLS2_k127_1525254_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 378.0
TLS2_k127_1525254_5 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 374.0
TLS2_k127_1525254_6 protein (some members contain a von Willebrand factor type A (vWA) domain - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006914 320.0
TLS2_k127_1525254_7 oxidoreductase activity K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 302.0
TLS2_k127_1525254_8 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.00000000000000000000000000000000000000000000000000000000004896 211.0
TLS2_k127_1525254_9 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000002839 158.0
TLS2_k127_1533826_0 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000115 161.0
TLS2_k127_1533826_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 0.000000000000000000000000000003593 129.0
TLS2_k127_1651185_0 COG1131 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007182 276.0
TLS2_k127_1651185_1 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000000000000000000000000007809 151.0
TLS2_k127_1651185_2 TIGRFAM HAD-superfamily subfamily IB hydrolase, TIGR01490 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000002585 131.0
TLS2_k127_1651185_3 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.000000000007069 66.0
TLS2_k127_1656447_0 - - - - 0.000000000000000000002156 102.0
TLS2_k127_1683638_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 4.743e-265 824.0
TLS2_k127_1683638_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K01719,K13542 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,4.1.1.37,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 617.0
TLS2_k127_1683638_2 NeuB family K03856,K04516 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 438.0
TLS2_k127_1683638_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000003952 138.0
TLS2_k127_1683638_4 Protein of unknown function (DUF507) - - - 0.00000000000000007252 85.0
TLS2_k127_1683638_5 - - - - 0.0000000000006062 82.0
TLS2_k127_1683638_6 Protein conserved in bacteria - - - 0.00000000002602 65.0
TLS2_k127_1683638_7 Protein of unknown function (DUF507) - - - 0.000004515 57.0
TLS2_k127_1729858_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 4.919e-200 650.0
TLS2_k127_1729858_1 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 586.0
TLS2_k127_1729858_10 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 369.0
TLS2_k127_1729858_11 quinone binding K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000713 367.0
TLS2_k127_1729858_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003146 304.0
TLS2_k127_1729858_13 Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000002404 236.0
TLS2_k127_1729858_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000003562 230.0
TLS2_k127_1729858_15 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000002063 226.0
TLS2_k127_1729858_16 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000004557 220.0
TLS2_k127_1729858_17 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000007372 201.0
TLS2_k127_1729858_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.0000000000000000000000000000000000000000000008395 173.0
TLS2_k127_1729858_19 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000005159 166.0
TLS2_k127_1729858_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 539.0
TLS2_k127_1729858_20 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000002025 163.0
TLS2_k127_1729858_21 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000002425 157.0
TLS2_k127_1729858_22 HAD-hyrolase-like - - - 0.000000000000000000000000000000000000008029 156.0
TLS2_k127_1729858_23 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00330 - 1.6.5.3 0.0000000000000000000000000000000000003343 146.0
TLS2_k127_1729858_24 TIGRFAM TIGR00725 family protein K06966 - 3.2.2.10 0.000000000000000000000000000000000004329 144.0
TLS2_k127_1729858_25 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000003609 117.0
TLS2_k127_1729858_26 PFAM NADH-ubiquinone plastoquinone oxidoreductase, chain 6 K00339 - 1.6.5.3 0.00000000000000000000001661 106.0
TLS2_k127_1729858_27 CbiX K03794 - 4.99.1.4 0.000000000000000000000145 101.0
TLS2_k127_1729858_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000001633 107.0
TLS2_k127_1729858_29 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000002107 107.0
TLS2_k127_1729858_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 535.0
TLS2_k127_1729858_30 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000001352 102.0
TLS2_k127_1729858_31 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000003996 81.0
TLS2_k127_1729858_32 - - - - 0.000005486 55.0
TLS2_k127_1729858_33 ABC-2 type transporter - - - 0.00002151 59.0
TLS2_k127_1729858_34 Belongs to the UPF0337 (CsbD) family - - - 0.0002916 46.0
TLS2_k127_1729858_35 HEAT repeats - - - 0.0003696 50.0
TLS2_k127_1729858_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 508.0
TLS2_k127_1729858_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 481.0
TLS2_k127_1729858_6 formate dehydrogenase (NAD+) activity K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 467.0
TLS2_k127_1729858_7 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 456.0
TLS2_k127_1729858_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 404.0
TLS2_k127_1729858_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 381.0
TLS2_k127_1744533_0 PFAM NAD dependent epimerase dehydratase family K01784,K08678 - 4.1.1.35,5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 323.0
TLS2_k127_1744533_1 -acetyltransferase K03830,K18816 - 2.3.1.82 0.000000000000000000000000000000000000000000905 164.0
TLS2_k127_1755269_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 1.386e-226 714.0
TLS2_k127_1755269_1 PFAM sigma-54 factor interaction domain-containing protein K02481,K07714,K10943 - - 0.000000000000000000000000000038 122.0
TLS2_k127_1755269_2 Parallel beta-helix repeat-containing protein - - - 0.000000000000539 82.0
TLS2_k127_1755269_3 von Willebrand factor type A domain K07114 - - 0.00002276 57.0
TLS2_k127_1755269_4 helix-turn-helix - - - 0.0002006 48.0
TLS2_k127_1755269_5 COG1413 FOG HEAT repeat K22221 - - 0.0009476 50.0
TLS2_k127_1823889_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.393e-201 648.0
TLS2_k127_1823889_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 566.0
TLS2_k127_1823889_2 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 421.0
TLS2_k127_1823889_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 372.0
TLS2_k127_1823889_4 Transcription factor zinc-finger K09981 - - 0.00000000000000000000001569 105.0
TLS2_k127_1823889_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000004519 93.0
TLS2_k127_1855540_0 COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit K14447 - 5.4.99.63 3.293e-289 900.0
TLS2_k127_1855540_1 Alcohol dehydrogenase GroES-like domain K00001,K14446,K17829 - 1.1.1.1,1.3.1.85,1.3.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 550.0
TLS2_k127_1918661_0 RDD family - - - 0.0000000000000000000000001864 113.0
TLS2_k127_1943388_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 5.923e-250 794.0
TLS2_k127_1943388_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 472.0
TLS2_k127_1943388_10 Belongs to the ompA family - - - 0.000000008345 69.0
TLS2_k127_1943388_11 Thrombospondin type 3 - - - 0.00000005627 67.0
TLS2_k127_1943388_2 Peptidase family M20/M25/M40 K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 338.0
TLS2_k127_1943388_3 PFAM Fibronectin type III domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 321.0
TLS2_k127_1943388_4 mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001618 285.0
TLS2_k127_1943388_5 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.000000000000000000000000000000000000000000000000000002106 205.0
TLS2_k127_1943388_6 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.000000000000000000000000000000000007877 145.0
TLS2_k127_1943388_7 Belongs to the bacterial histone-like protein family K05788 - - 0.00000000000000000000000000000000003218 138.0
TLS2_k127_1943388_8 metallopeptidase activity K06889 - - 0.0000000000000000000000000004656 134.0
TLS2_k127_1943388_9 Belongs to the ompA family K03286 - - 0.0000000000001495 84.0
TLS2_k127_1963467_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 481.0
TLS2_k127_1963467_1 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005979 259.0
TLS2_k127_1963467_2 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000001548 243.0
TLS2_k127_1963467_3 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.0000000003788 63.0
TLS2_k127_2004704_0 fatty acid synthase K00667,K00668 GO:0001676,GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0004315,GO:0004316,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016780,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0072330,GO:1900533,GO:1900535,GO:1901576 2.3.1.86 0.000000002894 71.0
TLS2_k127_2016680_0 TIGRFAM hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 463.0
TLS2_k127_2016680_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 440.0
TLS2_k127_2016680_2 Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities K00784 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016891,GO:0016893,GO:0016896,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000006424 264.0
TLS2_k127_2016680_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.000000000000000000000000000000000000002591 153.0
TLS2_k127_2016680_4 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000001335 107.0
TLS2_k127_2016680_5 terpene metabolic process K16218 GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0009987,GO:0010333,GO:0016829,GO:0016835,GO:0016838,GO:0042214,GO:0044237,GO:0044238,GO:0044255,GO:0071704 4.2.3.118 0.000000000008919 76.0
TLS2_k127_2022595_0 Domain of unknown function (DUF1707) - - - 0.00000008541 68.0
TLS2_k127_2022595_1 ABC transporter K01990,K21397 - - 0.00001187 61.0
TLS2_k127_2067563_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 5.062e-198 626.0
TLS2_k127_2067563_1 Riboflavin biosynthesis protein RibD K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 323.0
TLS2_k127_2067563_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000007413 207.0
TLS2_k127_2067563_3 TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000007124 179.0
TLS2_k127_2067563_4 Lumazine binding domain K00793 - 2.5.1.9 0.0000000000000000000000000000000000003639 144.0
TLS2_k127_2067563_5 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000002546 104.0
TLS2_k127_2067563_6 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000009005 81.0
TLS2_k127_2077550_0 PFAM Stage II sporulation K06381 - - 0.000000000000000000000000000000000000000000000000001198 197.0
TLS2_k127_2077550_1 PFAM NHL repeat - - - 0.00000000000000005273 89.0
TLS2_k127_2077550_2 pfam ammecr1 K09141 - - 0.00000000000000007662 90.0
TLS2_k127_2077550_3 Sulfotransferase family - - - 0.0001073 46.0
TLS2_k127_2088164_0 Uncharacterized protein conserved in bacteria (DUF2344) - - - 3.658e-217 704.0
TLS2_k127_2088164_1 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 566.0
TLS2_k127_2088164_10 Histidine kinase - - - 0.0000004489 52.0
TLS2_k127_2088164_11 Tetratricopeptide repeat - - - 0.000007815 54.0
TLS2_k127_2088164_2 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 484.0
TLS2_k127_2088164_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 387.0
TLS2_k127_2088164_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000827 381.0
TLS2_k127_2088164_5 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003147 274.0
TLS2_k127_2088164_6 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000008676 233.0
TLS2_k127_2088164_7 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000007517 134.0
TLS2_k127_2088164_8 cysteine-type peptidase activity K21471,K21473,K21687 - - 0.00000000000000000000000000002335 128.0
TLS2_k127_2088164_9 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000000000007939 117.0
TLS2_k127_2103576_0 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000001845 222.0
TLS2_k127_2103576_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000006877 162.0
TLS2_k127_2103576_2 ATP-dependent helicase deoxyribonuclease subunit B K16899 - 3.6.4.12 0.000000000000000174 94.0
TLS2_k127_2110973_0 DEAD/H associated K03724 - - 0.0 1471.0
TLS2_k127_2110973_1 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 397.0
TLS2_k127_2110973_2 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002725 285.0
TLS2_k127_2110973_3 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000001835 284.0
TLS2_k127_2110973_4 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000000000000000000003576 181.0
TLS2_k127_2110973_5 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000000003528 165.0
TLS2_k127_2110973_6 Membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.0000000000000000000000000000000000000004095 164.0
TLS2_k127_2110973_7 conserved protein (DUF2183) - - - 0.00000000000000000000000000000000000007168 154.0
TLS2_k127_2110973_8 Belongs to the UPF0250 family K09158 - - 0.0000000000000000000000006317 106.0
TLS2_k127_212168_0 threonine synthase activity K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 608.0
TLS2_k127_212168_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 363.0
TLS2_k127_212168_10 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000005839 68.0
TLS2_k127_212168_11 salt-induced outer membrane protein K07283 - - 0.0000004601 61.0
TLS2_k127_212168_12 histone H2A K63-linked ubiquitination - - - 0.0001879 56.0
TLS2_k127_212168_2 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 382.0
TLS2_k127_212168_3 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 349.0
TLS2_k127_212168_4 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 293.0
TLS2_k127_212168_5 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000695 223.0
TLS2_k127_212168_6 response to pH - - - 0.00000000000000000000000000000000000000000000007433 175.0
TLS2_k127_212168_7 TIGRFAM MoaD family protein K03636 - - 0.000000000000000000000000000000003021 130.0
TLS2_k127_212168_8 proteolysis K21140,K21147 - 2.7.7.80,2.8.1.11,3.13.1.6 0.0000000000000000000000000001078 123.0
TLS2_k127_212168_9 methionine transport K02071 - - 0.000000000000855 72.0
TLS2_k127_2148601_0 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000005116 224.0
TLS2_k127_2148601_1 Methyltransferase domain K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000000001169 214.0
TLS2_k127_2148601_3 NAD FAD-binding protein - - - 0.000000000000000000000000000275 122.0
TLS2_k127_2148601_4 Sulfatase-modifying factor enzyme 1 K20333 - - 0.0000000002919 64.0
TLS2_k127_2148601_5 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00001864 51.0
TLS2_k127_2158352_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 509.0
TLS2_k127_2158352_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.0000000000000000000000000000000000000000000000000002441 189.0
TLS2_k127_2158352_2 Recombinase zinc beta ribbon domain K06400 - - 0.0000002968 53.0
TLS2_k127_2158352_3 ParB domain protein nuclease K03497 - - 0.000001879 56.0
TLS2_k127_2186177_0 Belongs to the RtcB family K14415 - 6.5.1.3 7.412e-194 616.0
TLS2_k127_2186177_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 498.0
TLS2_k127_2186177_10 Diadenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000002293 228.0
TLS2_k127_2186177_11 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000000003037 225.0
TLS2_k127_2186177_12 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000203 221.0
TLS2_k127_2186177_13 cytochrome c biogenesis protein, transmembrane region K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000001062 224.0
TLS2_k127_2186177_14 Rhomboid family K02441 - - 0.00000000000000000000000000000000000000000000000000000006617 207.0
TLS2_k127_2186177_15 PGAP1-like protein - - - 0.000000000000000000000000000000000000000000000000000004352 199.0
TLS2_k127_2186177_16 ribosomal large subunit export from nucleus - - - 0.00000000000000000000000000000000000008499 148.0
TLS2_k127_2186177_17 PFAM Peptidase family M23 K21471 - - 0.00000000000000000000000000000000009136 140.0
TLS2_k127_2186177_18 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 - 2.4.2.1,2.4.2.2 0.0000000000000000000000001099 108.0
TLS2_k127_2186177_19 PFAM Archease protein family (DUF101 UPF0211) - - - 0.0000000000000000000004269 101.0
TLS2_k127_2186177_2 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 465.0
TLS2_k127_2186177_20 Virulence factor BrkB K07058 - - 0.0000000000000000004862 98.0
TLS2_k127_2186177_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 326.0
TLS2_k127_2186177_4 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009721 326.0
TLS2_k127_2186177_5 PFAM Glycosyl transferase, family 3 K00756,K00758 - 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 325.0
TLS2_k127_2186177_6 DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001016 282.0
TLS2_k127_2186177_7 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000892 247.0
TLS2_k127_2186177_8 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008774 239.0
TLS2_k127_2186177_9 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002732 245.0
TLS2_k127_2223436_0 Cytochrome b(N-terminal)/b6/petB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 414.0
TLS2_k127_2223436_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 342.0
TLS2_k127_2223436_2 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001016 276.0
TLS2_k127_2223436_3 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.000000000000000000000000000000000000000000000000000000000000000000251 235.0
TLS2_k127_2241510_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 447.0
TLS2_k127_2241510_1 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 443.0
TLS2_k127_2241510_2 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 366.0
TLS2_k127_2241510_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002349 272.0
TLS2_k127_2241510_4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000003413 207.0
TLS2_k127_2241510_5 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000001564 146.0
TLS2_k127_2241510_6 Belongs to the ArsC family K00537 - 1.20.4.1 0.00000000000000000000000000000000000008001 145.0
TLS2_k127_2241510_7 SMART serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000001253 117.0
TLS2_k127_2241510_8 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000001959 116.0
TLS2_k127_2241510_9 Belongs to the BolA IbaG family - - - 0.0000000000000000000002882 99.0
TLS2_k127_2282039_0 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 333.0
TLS2_k127_2282039_1 Cadherin repeats. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003647 276.0
TLS2_k127_2282039_10 protein N-acetylglucosaminyltransferase activity - - - 0.000000006935 69.0
TLS2_k127_2282039_11 HEAT repeat - - - 0.000001373 62.0
TLS2_k127_2282039_12 Peptidase C14 caspase catalytic subunit p20 - - - 0.0000124 56.0
TLS2_k127_2282039_13 - - - - 0.000595 50.0
TLS2_k127_2282039_2 antibiotic catabolic process K13277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000114 259.0
TLS2_k127_2282039_3 PIN domain K18828 - - 0.000000000000000000000000000000000000000000000002421 176.0
TLS2_k127_2282039_4 - K18829 - - 0.000000000000000000000001634 104.0
TLS2_k127_2282039_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000009528 93.0
TLS2_k127_2282039_6 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000003757 88.0
TLS2_k127_2282039_7 Response regulator receiver domain protein - - - 0.0000000001142 66.0
TLS2_k127_2282039_8 polysaccharide catabolic process K01179 - 3.2.1.4 0.00000000169 71.0
TLS2_k127_2282039_9 Response regulator receiver domain protein - - - 0.000000001708 69.0
TLS2_k127_2305994_0 Thrombospondin type 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000005927 255.0
TLS2_k127_2305994_1 Domain of unknown function (DUF4215) - - - 0.000000000000000000000000000000000000000000000000000000000000000001847 251.0
TLS2_k127_2305994_2 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000001243 117.0
TLS2_k127_2305994_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000003961 106.0
TLS2_k127_2305994_4 Forkhead associated domain - - - 0.00000000007273 68.0
TLS2_k127_2305994_5 deoxyhypusine monooxygenase activity - - - 0.00000018 67.0
TLS2_k127_2305994_6 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000001096 61.0
TLS2_k127_2319289_0 Belongs to the heme-copper respiratory oxidase family - - - 3.874e-229 737.0
TLS2_k127_2319289_1 PFAM FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 567.0
TLS2_k127_2319289_10 SNARE associated Golgi protein - - - 0.0000000846 56.0
TLS2_k127_2319289_11 - - - - 0.0000001432 59.0
TLS2_k127_2319289_2 Cytochrome c oxidase subunit K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008663 282.0
TLS2_k127_2319289_3 Rieske [2Fe-2S] domain K03886 - - 0.000000000000000000000000000000000000000000000000000000000561 206.0
TLS2_k127_2319289_4 cytochrome c oxidase K02862 - - 0.0000000000000000000000000000000000003643 156.0
TLS2_k127_2319289_5 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000002386 139.0
TLS2_k127_2319289_6 Belongs to the UPF0337 (CsbD) family - - - 0.00000000000000000000003226 100.0
TLS2_k127_2319289_7 - - - - 0.000000000000000000006128 96.0
TLS2_k127_2319289_8 BON domain - - - 0.0000000000000871 75.0
TLS2_k127_2319289_9 Protein of unknown function (DUF1328) - - - 0.0000000000005983 72.0
TLS2_k127_2325572_0 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K10824,K12372,K13892 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 3.6.3.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 324.0
TLS2_k127_2344877_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 1.271e-194 619.0
TLS2_k127_2344877_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 501.0
TLS2_k127_2344877_2 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 479.0
TLS2_k127_2344877_3 Inositol monophosphatase K01082,K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 287.0
TLS2_k127_2344877_4 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000002802 172.0
TLS2_k127_2344877_5 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000005722 172.0
TLS2_k127_2344877_6 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000000001411 133.0
TLS2_k127_2344877_7 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 0.00000000000000000000000000003663 128.0
TLS2_k127_2344877_8 nuclear chromosome segregation - - - 0.00000000000000000000000000723 124.0
TLS2_k127_2344877_9 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000002527 111.0
TLS2_k127_236427_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 2.185e-212 663.0
TLS2_k127_236427_1 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit K01844 - 5.4.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 501.0
TLS2_k127_236427_2 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 458.0
TLS2_k127_236427_3 Lysine 2,3-aminomutase K01843 - 5.4.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 448.0
TLS2_k127_236427_4 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 418.0
TLS2_k127_236427_5 alcohol dehydrogenase K18012 - 1.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 290.0
TLS2_k127_236427_6 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000127 153.0
TLS2_k127_236427_7 Archaea bacterial proteins of unknown function K06921 - - 0.00003153 47.0
TLS2_k127_236427_8 Archaea bacterial proteins of unknown function K06921 - - 0.0002626 45.0
TLS2_k127_237994_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576 380.0
TLS2_k127_237994_1 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 337.0
TLS2_k127_237994_10 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000005524 119.0
TLS2_k127_237994_2 MMPL family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006808 328.0
TLS2_k127_237994_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001814 286.0
TLS2_k127_237994_4 Glutamate-cysteine ligase K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002122 280.0
TLS2_k127_237994_5 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000003251 255.0
TLS2_k127_237994_6 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000003963 214.0
TLS2_k127_237994_7 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000008074 151.0
TLS2_k127_237994_8 PFAM small multidrug resistance protein K11741 - - 0.00000000000000000000000000000000001626 137.0
TLS2_k127_237994_9 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000000000698 136.0
TLS2_k127_2402144_0 1-Cys peroxiredoxin K11188 - 1.11.1.15,1.11.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004419 333.0
TLS2_k127_2402144_1 6-phosphogluconolactonase activity - - - 0.0000000000000000000000000000000000000000000000003001 192.0
TLS2_k127_2402144_2 malic enzyme K00029 - 1.1.1.40 0.0000000000000000000000000000000000001948 164.0
TLS2_k127_2402144_3 PFAM Integral membrane protein TerC K05794 - - 0.0000000000001901 72.0
TLS2_k127_2420321_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 410.0
TLS2_k127_2420321_1 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000000000000242 196.0
TLS2_k127_2420321_2 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.00000000000000000000000000000000000000000000000000001153 196.0
TLS2_k127_2420321_3 - - - - 0.0000005414 61.0
TLS2_k127_2439662_0 Homocysteine s-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 407.0
TLS2_k127_2439662_1 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 390.0
TLS2_k127_2439662_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 305.0
TLS2_k127_2439662_3 Protein of unknown function (DUF3050) - - - 0.000000000000000000000000000000000000000000000000000385 190.0
TLS2_k127_2439662_4 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000001634 172.0
TLS2_k127_2439662_5 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.0002385 49.0
TLS2_k127_2439662_6 antigen 17 - GO:0000226,GO:0001578,GO:0003341,GO:0003351,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0005929,GO:0005930,GO:0006928,GO:0006996,GO:0007010,GO:0007017,GO:0007018,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0032838,GO:0035082,GO:0042995,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044422,GO:0044424,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044447,GO:0044463,GO:0044464,GO:0044782,GO:0060271,GO:0070925,GO:0071840,GO:0097014,GO:0099568,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:1904158,GO:1990716 - 0.0002614 53.0
TLS2_k127_255908_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 0.00000000000000000000000002021 127.0
TLS2_k127_256880_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 1.356e-274 871.0
TLS2_k127_256880_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 4.968e-246 781.0
TLS2_k127_256880_10 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000004262 205.0
TLS2_k127_256880_11 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000005827 211.0
TLS2_k127_256880_12 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000001116 179.0
TLS2_k127_256880_13 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000002803 166.0
TLS2_k127_256880_14 electron transfer activity - - - 0.00000000000000000001675 99.0
TLS2_k127_256880_15 Outer membrane protein (OmpH-like) K06142 - - 0.000000000000000003819 91.0
TLS2_k127_256880_16 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000001015 78.0
TLS2_k127_256880_17 Belongs to the UPF0434 family K09791 - - 0.00000000001417 74.0
TLS2_k127_256880_18 FHA domain - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000008219 62.0
TLS2_k127_256880_19 - - - - 0.00003306 53.0
TLS2_k127_256880_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 590.0
TLS2_k127_256880_20 Glycosyl transferase family 2 - - - 0.0002199 52.0
TLS2_k127_256880_3 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009587 586.0
TLS2_k127_256880_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 553.0
TLS2_k127_256880_5 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 302.0
TLS2_k127_256880_6 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002624 273.0
TLS2_k127_256880_7 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000002854 218.0
TLS2_k127_256880_8 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000002985 223.0
TLS2_k127_256880_9 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000001999 216.0
TLS2_k127_261106_0 phosphatase K20074 - 3.1.3.16 0.00000000005441 77.0
TLS2_k127_261106_1 ATPase activity - - - 0.00000189 62.0
TLS2_k127_263152_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1111.0
TLS2_k127_263152_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005981 508.0
TLS2_k127_263152_10 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000001193 268.0
TLS2_k127_263152_11 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005609 261.0
TLS2_k127_263152_12 Glycosyl transferase K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002599 263.0
TLS2_k127_263152_13 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000908 223.0
TLS2_k127_263152_14 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000003074 216.0
TLS2_k127_263152_15 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000006753 217.0
TLS2_k127_263152_16 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000007684 194.0
TLS2_k127_263152_17 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000003658 186.0
TLS2_k127_263152_18 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.00000000000000000000000000000000000000000000000007393 185.0
TLS2_k127_263152_19 - - - - 0.0000000000000000000000000000000000000000000000001424 196.0
TLS2_k127_263152_2 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 431.0
TLS2_k127_263152_20 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000002968 171.0
TLS2_k127_263152_21 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000000000000000000005302 132.0
TLS2_k127_263152_22 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000623 142.0
TLS2_k127_263152_23 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000002952 136.0
TLS2_k127_263152_24 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000001818 129.0
TLS2_k127_263152_25 CAAX protease self-immunity K07052 - - 0.0000000000000000000003619 108.0
TLS2_k127_263152_26 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000008414 95.0
TLS2_k127_263152_27 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.0000000000000001641 79.0
TLS2_k127_263152_28 PFAM Glycosyl transferase family 2 - - - 0.00000000001258 67.0
TLS2_k127_263152_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 435.0
TLS2_k127_263152_4 ABC-type multidrug transport system ATPase and permease K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 432.0
TLS2_k127_263152_5 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 419.0
TLS2_k127_263152_6 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 301.0
TLS2_k127_263152_7 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 285.0
TLS2_k127_263152_8 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003585 278.0
TLS2_k127_263152_9 Uncharacterised nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006778 272.0
TLS2_k127_2651765_0 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 437.0
TLS2_k127_2651765_1 transferase activity, transferring glycosyl groups - - - 0.000000000000001517 79.0
TLS2_k127_2651765_2 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.000000002233 64.0
TLS2_k127_2661217_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 519.0
TLS2_k127_2661217_1 D-isomer specific 2-hydroxyacid dehydrogenase K03778 - 1.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 443.0
TLS2_k127_2661217_2 protein conserved in bacteria K09919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 314.0
TLS2_k127_2661217_3 Gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 318.0
TLS2_k127_2661217_4 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001801 265.0
TLS2_k127_2661217_5 PFAM Bacterial protein of - - - 0.000000000000000000000000000000000000000000000004906 188.0
TLS2_k127_2661217_6 FAD dependent oxidoreductase K07137 - - 0.000000000000000000000000000000000000000195 155.0
TLS2_k127_2661217_7 PFAM peptidase U32 K08303 - - 0.0000000000000004271 81.0
TLS2_k127_2661217_8 Phosphatase K20074 - 3.1.3.16 0.0009811 55.0
TLS2_k127_2664350_0 response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 376.0
TLS2_k127_2664350_1 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000072 264.0
TLS2_k127_2664350_2 TonB dependent receptor K16092 - - 0.0000000000000000000000000000000000000000000000000000286 208.0
TLS2_k127_2664350_3 PFAM conserved K02069 - - 0.00000000000000000000000000000000000000000000000003884 190.0
TLS2_k127_2664350_4 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 0.0000001543 62.0
TLS2_k127_2691966_0 CTP synthase N-terminus K01937 - 6.3.4.2 9.352e-233 731.0
TLS2_k127_2691966_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 514.0
TLS2_k127_2691966_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 512.0
TLS2_k127_2691966_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 371.0
TLS2_k127_2691966_4 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000002308 250.0
TLS2_k127_2691966_5 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000000000000000000000002212 172.0
TLS2_k127_2691966_6 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000000000004867 105.0
TLS2_k127_2691966_7 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000006552 96.0
TLS2_k127_2691966_8 system, fructose subfamily IIA component K02793 - 2.7.1.191 0.000000000000000000009171 97.0
TLS2_k127_273799_0 DNA polymerase A domain K02335 - 2.7.7.7 6.086e-265 843.0
TLS2_k127_273799_1 - - - - 0.00000000000000000000000000000000000000000000000002328 182.0
TLS2_k127_273799_10 COG NOG14552 non supervised orthologous group - - - 0.00000000000003507 72.0
TLS2_k127_273799_12 - - - - 0.00000000000279 70.0
TLS2_k127_273799_15 - - - - 0.000000001674 60.0
TLS2_k127_273799_17 Bacterial Ig-like domain (group 3) - - - 0.0000000282 68.0
TLS2_k127_273799_18 Protein of unknown function (DUF3341) - - - 0.0000000801 61.0
TLS2_k127_273799_2 - - - - 0.00000000000000000000000000004954 117.0
TLS2_k127_273799_20 - - - - 0.0000272 47.0
TLS2_k127_273799_3 - - - - 0.000000000000000000000001353 104.0
TLS2_k127_273799_4 - - - - 0.00000000000000003522 83.0
TLS2_k127_273799_5 - - - - 0.00000000000000005674 82.0
TLS2_k127_273799_6 - - - - 0.0000000000000006228 79.0
TLS2_k127_273799_7 - - - - 0.000000000000005922 77.0
TLS2_k127_273799_8 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000006637 87.0
TLS2_k127_2741141_0 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 395.0
TLS2_k127_2741141_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009224 327.0
TLS2_k127_2741141_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000007769 267.0
TLS2_k127_2749268_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.061e-246 782.0
TLS2_k127_2749268_1 Protein of unknown function, DUF255 K06888 - - 9.013e-196 637.0
TLS2_k127_2749268_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 573.0
TLS2_k127_2749268_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 530.0
TLS2_k127_2749268_4 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 441.0
TLS2_k127_2749268_5 oligoendopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 356.0
TLS2_k127_2749268_6 serine threonine protein phosphatase K20074 - 3.1.3.16 0.0000004882 66.0
TLS2_k127_2789438_0 PGAP1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001452 243.0
TLS2_k127_2789438_1 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.000000000000004721 77.0
TLS2_k127_2789438_2 Protein of unknown function (DUF3592) - - - 0.0000000008476 71.0
TLS2_k127_2792746_0 Aldehyde dehydrogenase family K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 578.0
TLS2_k127_2792746_1 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 509.0
TLS2_k127_2792746_10 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000000000000000000000007532 161.0
TLS2_k127_2792746_11 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05889,K12678 - 1.1.2.6 0.0000000000000000000000000000000003799 151.0
TLS2_k127_2792746_12 cell division K03586 GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944 - 0.0000002954 61.0
TLS2_k127_2792746_13 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) - - - 0.000005072 56.0
TLS2_k127_2792746_14 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.00002173 48.0
TLS2_k127_2792746_15 Protein tyrosine kinase K12132 - 2.7.11.1 0.0002892 54.0
TLS2_k127_2792746_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 449.0
TLS2_k127_2792746_3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 436.0
TLS2_k127_2792746_4 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 372.0
TLS2_k127_2792746_5 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 347.0
TLS2_k127_2792746_6 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 340.0
TLS2_k127_2792746_7 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007157 324.0
TLS2_k127_2792746_8 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 349.0
TLS2_k127_2792746_9 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001207 284.0
TLS2_k127_28053_0 Lytic transglycosylase catalytic K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006507 296.0
TLS2_k127_28053_1 similarity to GP 17427840 K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001206 269.0
TLS2_k127_28053_2 Two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000001814 267.0
TLS2_k127_28053_3 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000593 173.0
TLS2_k127_28053_4 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000004189 118.0
TLS2_k127_28053_5 to Ralstonia solanacearum ISRso14-transposase orfA protein SWALL Q8XGL4 (EMBL AL646083) (87 aa) fasta scores E() 2.1e-29, 93.1 id in 87 aa K07497 - - 0.0000000000000000000005891 98.0
TLS2_k127_2862205_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 6.221e-229 720.0
TLS2_k127_2862205_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 470.0
TLS2_k127_2862205_10 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K07081,K11782,K11784 - 1.21.98.1,4.2.1.151 0.000000000000000000000000000003602 130.0
TLS2_k127_2862205_11 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000001187 121.0
TLS2_k127_2862205_2 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 454.0
TLS2_k127_2862205_3 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009587 389.0
TLS2_k127_2862205_4 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 373.0
TLS2_k127_2862205_5 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000947 338.0
TLS2_k127_2862205_6 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009815 293.0
TLS2_k127_2862205_7 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000000000006447 188.0
TLS2_k127_2862205_8 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K20810 - 3.5.4.40 0.000000000000000000000000000000000000000000001763 186.0
TLS2_k127_2862205_9 Sulfatase-modifying factor enzyme 1 K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000001525 181.0
TLS2_k127_2865406_0 Domain of unknown function (DUF4126) - - - 0.00000000000000000000000000000000000000000000000001181 194.0
TLS2_k127_2865406_1 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000008723 159.0
TLS2_k127_2867413_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.543e-284 890.0
TLS2_k127_2867413_1 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 551.0
TLS2_k127_2867413_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 407.0
TLS2_k127_2867413_3 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000744 344.0
TLS2_k127_296412_0 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000607 58.0
TLS2_k127_296412_1 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.0006933 51.0
TLS2_k127_2973520_0 DNA Topoisomerase IV K02469 - 5.99.1.3 0.0 1048.0
TLS2_k127_2973520_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.658e-296 933.0
TLS2_k127_2973520_10 Two component transcriptional regulator, winged helix family K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009762 264.0
TLS2_k127_2973520_11 PBP superfamily domain K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007267 266.0
TLS2_k127_2973520_12 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000437 250.0
TLS2_k127_2973520_13 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000002827 201.0
TLS2_k127_2973520_14 Protein of unknown function (DUF520) K09767 - - 0.00000000000000000000000000000000000000000000001877 186.0
TLS2_k127_2973520_15 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000005346 164.0
TLS2_k127_2973520_16 nuclease activity - - - 0.00000000000000000000000000000000000008374 145.0
TLS2_k127_2973520_17 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000005734 134.0
TLS2_k127_2973520_18 Nitrogen regulatory protein P-II K02589 - - 0.00000000000000000000000000000009081 128.0
TLS2_k127_2973520_19 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000002247 126.0
TLS2_k127_2973520_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 493.0
TLS2_k127_2973520_20 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000005665 117.0
TLS2_k127_2973520_21 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000003431 104.0
TLS2_k127_2973520_22 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.00000000000000000002084 105.0
TLS2_k127_2973520_23 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000007361 95.0
TLS2_k127_2973520_24 Domain of unknown function (DUF1844) - - - 0.00000000000000001071 88.0
TLS2_k127_2973520_25 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K03769,K07533 - 5.2.1.8 0.000000000002057 79.0
TLS2_k127_2973520_26 protein trimerization K20543 - - 0.0000000000137 76.0
TLS2_k127_2973520_27 Bacterial antitoxin of type II TA system, VapB - - - 0.000000001279 62.0
TLS2_k127_2973520_28 Belongs to the P(II) protein family K04751 - - 0.000000003995 61.0
TLS2_k127_2973520_3 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 422.0
TLS2_k127_2973520_4 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 390.0
TLS2_k127_2973520_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 338.0
TLS2_k127_2973520_6 Phosphate transport system permease K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 321.0
TLS2_k127_2973520_7 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 312.0
TLS2_k127_2973520_8 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000179 268.0
TLS2_k127_2973520_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001009 284.0
TLS2_k127_303841_0 Aminoacyl-tRNA editing domain K01881 - 6.1.1.15 4.606e-209 664.0
TLS2_k127_303841_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 601.0
TLS2_k127_303841_10 repeat-containing protein - - - 0.0000006379 61.0
TLS2_k127_303841_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 398.0
TLS2_k127_303841_3 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004545 275.0
TLS2_k127_303841_4 Zinc dependent phospholipase C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001362 249.0
TLS2_k127_303841_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000003494 243.0
TLS2_k127_303841_6 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000203 217.0
TLS2_k127_303841_7 PFAM Haloacid dehalogenase domain protein hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000004458 172.0
TLS2_k127_303841_9 Memo-like protein K06990 - - 0.00000000000000000000000006825 111.0
TLS2_k127_3053451_0 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 541.0
TLS2_k127_3053451_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 469.0
TLS2_k127_3053451_10 Domain of unknown function (DUF202) K00389 - - 0.0000000000000000000006078 100.0
TLS2_k127_3053451_11 Protein of unknown function (DUF861) - - - 0.000000000000000000002045 100.0
TLS2_k127_3053451_12 Peptidase family M23 - - - 0.000000000000000904 89.0
TLS2_k127_3053451_13 - - - - 0.000000000000004878 89.0
TLS2_k127_3053451_14 regulator of chromosome condensation, RCC1 - - - 0.00000000001529 78.0
TLS2_k127_3053451_15 Belongs to the universal stress protein A family - - - 0.00000009407 63.0
TLS2_k127_3053451_16 helix_turn_helix, Lux Regulon - - - 0.0000005396 61.0
TLS2_k127_3053451_17 Parallel beta-helix repeats - - - 0.00002825 57.0
TLS2_k127_3053451_18 PKD domain protein - - - 0.0002592 54.0
TLS2_k127_3053451_19 PBS lyase HEAT-like repeat - - - 0.0002681 54.0
TLS2_k127_3053451_2 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000000000563 207.0
TLS2_k127_3053451_20 amine dehydrogenase activity - - - 0.0003256 53.0
TLS2_k127_3053451_3 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.000000000000000000000000000000000000000000000000001629 186.0
TLS2_k127_3053451_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000004372 165.0
TLS2_k127_3053451_5 Cadherin repeats. - - - 0.0000000000000000000000000000000000496 156.0
TLS2_k127_3053451_6 Sh3 type 3 domain protein K02450,K12132 - 2.7.11.1 0.00000000000000000000000000000001125 139.0
TLS2_k127_3053451_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000001221 130.0
TLS2_k127_3053451_8 - - - - 0.00000000000000000000003245 115.0
TLS2_k127_3053451_9 - - - - 0.0000000000000000000001954 115.0
TLS2_k127_3089827_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 5.953e-316 977.0
TLS2_k127_3089827_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 353.0
TLS2_k127_3089827_2 Beta-propeller repeat - - - 0.000000000000000000000000000007927 138.0
TLS2_k127_3089827_3 thiamine biosynthesis protein ThiS K03154 - - 0.00000003408 57.0
TLS2_k127_3229866_0 Acetyl propionyl-CoA carboxylase, alpha subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 507.0
TLS2_k127_323979_0 elongation factor Tu domain 2 protein K06207 - - 1.448e-283 881.0
TLS2_k127_323979_1 secondary active sulfate transmembrane transporter activity K06901 - - 6.28e-213 675.0
TLS2_k127_323979_10 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000001117 212.0
TLS2_k127_323979_11 Alpha beta hydrolase fold protein - - - 0.000000000000000000000000000000000000000000000000003718 201.0
TLS2_k127_323979_12 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000002146 152.0
TLS2_k127_323979_13 quinone binding - - - 0.00000000000000000000000000007143 130.0
TLS2_k127_323979_14 UV-endonuclease UvdE - - - 0.00000000000000000002178 99.0
TLS2_k127_323979_15 Protein of unknown function (DUF1232) - - - 0.00000000000000004444 89.0
TLS2_k127_323979_16 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000007848 87.0
TLS2_k127_323979_17 Tetratricopeptide repeat - - - 0.00000000000004427 85.0
TLS2_k127_323979_18 Dodecin K09165 - - 0.000000000002031 69.0
TLS2_k127_323979_19 - - - - 0.00000000000936 73.0
TLS2_k127_323979_2 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.606e-197 629.0
TLS2_k127_323979_20 Tetratricopeptide repeat protein - - - 0.0000007547 59.0
TLS2_k127_323979_21 - - - - 0.00005724 46.0
TLS2_k127_323979_22 - - - - 0.0001284 54.0
TLS2_k127_323979_23 EF hand - - - 0.0002429 52.0
TLS2_k127_323979_3 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 627.0
TLS2_k127_323979_4 HI0933 family K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000557 443.0
TLS2_k127_323979_5 amino acid-binding ACT domain protein K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 380.0
TLS2_k127_323979_6 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 306.0
TLS2_k127_323979_7 prephenate dehydrogenase K00220 - 1.3.1.12,1.3.1.43 0.0000000000000000000000000000000000000000000000000000000000008035 222.0
TLS2_k127_323979_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000005308 214.0
TLS2_k127_323979_9 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000009565 213.0
TLS2_k127_326838_0 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 513.0
TLS2_k127_326838_1 Bacterial extracellular solute-binding protein, family 7 K11688,K21395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002706 282.0
TLS2_k127_326838_2 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002247 252.0
TLS2_k127_326838_3 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000003896 194.0
TLS2_k127_326838_4 PIN domain - - - 0.00000000000000000000000000001558 122.0
TLS2_k127_326838_5 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.0000000000000000000000000001035 123.0
TLS2_k127_326838_6 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000002794 70.0
TLS2_k127_3277494_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 565.0
TLS2_k127_3305156_0 PrkA AAA domain K07180 - - 0.0 1034.0
TLS2_k127_3305156_1 SpoVR like protein K06415 - - 2.659e-210 665.0
TLS2_k127_3305156_10 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000004694 186.0
TLS2_k127_3305156_11 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000239 179.0
TLS2_k127_3305156_12 - - - - 0.000000000000000000000003819 109.0
TLS2_k127_3305156_13 Role in flagellar biosynthesis K02421 - - 0.0000000000000000000000071 111.0
TLS2_k127_3305156_14 Bacterial export proteins, family 3 K02420 - - 0.000000000000000000005958 94.0
TLS2_k127_3305156_15 peptidyl-tyrosine sulfation - - - 0.00000000000000000001928 98.0
TLS2_k127_3305156_16 YGGT family K02221 - - 0.00000000000000000005903 101.0
TLS2_k127_3305156_17 protein conserved in bacteria - - - 0.00000000000000000006252 91.0
TLS2_k127_3305156_18 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000001319 87.0
TLS2_k127_3305156_19 peptidyl-tyrosine sulfation - - - 0.0000000000000006542 87.0
TLS2_k127_3305156_2 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 505.0
TLS2_k127_3305156_20 COG1886 Flagellar motor switch type III secretory pathway protein K02416,K03225 - - 0.0000000000001515 78.0
TLS2_k127_3305156_21 Belongs to the UPF0235 family K09131 - - 0.0000000000002784 78.0
TLS2_k127_3305156_22 flagellar motor switch protein FliM K02416 - - 0.0000001064 63.0
TLS2_k127_3305156_3 sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 416.0
TLS2_k127_3305156_4 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 348.0
TLS2_k127_3305156_5 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 340.0
TLS2_k127_3305156_6 Type III secretion K03226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001392 278.0
TLS2_k127_3305156_7 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001521 261.0
TLS2_k127_3305156_8 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000002717 238.0
TLS2_k127_3305156_9 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000351 207.0
TLS2_k127_3309196_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 583.0
TLS2_k127_3309196_1 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 442.0
TLS2_k127_3309196_2 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 334.0
TLS2_k127_3309196_3 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001436 251.0
TLS2_k127_3309196_4 PFAM regulatory protein TetR K13770 - - 0.00000000000000000000000000000000000000000000000000000000000001953 220.0
TLS2_k127_3309196_5 radical SAM - - - 0.00000000000000000000000000000000000000000001887 179.0
TLS2_k127_3309196_6 Belongs to the ABC transporter superfamily K02068 - - 0.000000000000000000000000000000000000000009396 162.0
TLS2_k127_3309196_7 His Kinase A (phosphoacceptor) domain K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000009651 142.0
TLS2_k127_3309196_8 ABC transporter, substratebinding protein K02035 - - 0.000005097 59.0
TLS2_k127_3396168_0 dCMP deaminase activity K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000402 200.0
TLS2_k127_3396168_1 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000003002 164.0
TLS2_k127_3396168_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000009203 124.0
TLS2_k127_3396168_3 AAA domain - - - 0.0000000000000000000000000002709 127.0
TLS2_k127_3396168_4 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000001132 117.0
TLS2_k127_3396168_5 Putative zinc-finger - - - 0.00007329 54.0
TLS2_k127_3396168_6 Outer membrane efflux protein - - - 0.0004148 51.0
TLS2_k127_3422970_0 NGG1p interacting factor 3 K22391 - 3.5.4.16 0.00000000000000000000000000000000000000000000000005328 192.0
TLS2_k127_3422970_1 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.000000000000000000000000000000000000005811 160.0
TLS2_k127_3422970_2 response regulator, receiver - - - 0.0000000000000000000000001641 111.0
TLS2_k127_3422970_3 methyltransferase - - - 0.000005228 58.0
TLS2_k127_346374_0 Required for chromosome condensation and partitioning K03529 - - 9.929e-245 813.0
TLS2_k127_346374_1 electron transfer activity K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 492.0
TLS2_k127_3571125_0 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 518.0
TLS2_k127_3571125_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000001096 244.0
TLS2_k127_3571125_2 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 K03775 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 0.00000000000000000000000000006824 121.0
TLS2_k127_3571125_3 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.00000000000000000000000000009498 120.0
TLS2_k127_3571125_5 domain, Protein K14645 - - 0.0001781 50.0
TLS2_k127_3571125_6 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively K01243 - 3.2.2.9 0.0004547 51.0
TLS2_k127_3599942_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000478 353.0
TLS2_k127_3599942_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000001168 205.0
TLS2_k127_3599942_2 Domain of unknown function (DUF366) K09139 - - 0.000000000000000000000000000000000000000000000006793 178.0
TLS2_k127_3599942_3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000001352 151.0
TLS2_k127_3599942_4 PHB/PHA accumulation regulator DNA-binding domain - - - 0.0000000000000000000000000000000558 131.0
TLS2_k127_3599942_5 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000001415 121.0
TLS2_k127_3599942_6 mttA/Hcf106 family K03116 - - 0.000000000004022 68.0
TLS2_k127_3814717_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 410.0
TLS2_k127_3814717_1 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000001764 94.0
TLS2_k127_3814717_2 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000006141 74.0
TLS2_k127_382526_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 361.0
TLS2_k127_382526_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000005122 53.0
TLS2_k127_3872582_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 304.0
TLS2_k127_3872582_1 In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold. K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002986 270.0
TLS2_k127_3872582_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000021 225.0
TLS2_k127_3872582_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000001447 145.0
TLS2_k127_3872582_4 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000009001 77.0
TLS2_k127_3872582_5 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000002472 75.0
TLS2_k127_3872582_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000005044 58.0
TLS2_k127_3872582_8 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000003069 55.0
TLS2_k127_3872626_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 392.0
TLS2_k127_3872626_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000366 296.0
TLS2_k127_3872626_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000002011 234.0
TLS2_k127_3872626_3 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000001322 184.0
TLS2_k127_3872626_4 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000002206 174.0
TLS2_k127_3872626_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000009977 143.0
TLS2_k127_3872626_6 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000001574 121.0
TLS2_k127_3872626_7 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000002418 122.0
TLS2_k127_3872626_8 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000184 94.0
TLS2_k127_3872626_9 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000002472 75.0
TLS2_k127_3876335_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 461.0
TLS2_k127_3876335_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000008188 231.0
TLS2_k127_388214_0 UDP binding domain K02474,K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 540.0
TLS2_k127_388214_1 elongation factor G K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 555.0
TLS2_k127_388214_10 Mediates influx of magnesium ions K03284 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000005934 167.0
TLS2_k127_388214_11 Domain of unknown function (DUF4301) - - - 0.0000000000000000974 79.0
TLS2_k127_388214_13 - - - - 0.00003641 51.0
TLS2_k127_388214_2 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005526 354.0
TLS2_k127_388214_3 desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 331.0
TLS2_k127_388214_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004271 275.0
TLS2_k127_388214_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000168 246.0
TLS2_k127_388214_6 Transcriptional regulator, CarD family K07736 - - 0.00000000000000000000000000000000000000000000000000000000001878 211.0
TLS2_k127_388214_7 Bacterial phospho-glucose isomerase C-terminal SIS domain K15916 - 5.3.1.8,5.3.1.9 0.00000000000000000000000000000000000000000000000000000004695 208.0
TLS2_k127_388214_8 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000709 181.0
TLS2_k127_388214_9 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000000000002135 162.0
TLS2_k127_3883546_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.297e-284 897.0
TLS2_k127_3883546_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 453.0
TLS2_k127_3883546_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 319.0
TLS2_k127_3883546_3 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000001161 199.0
TLS2_k127_3885207_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009923 361.0
TLS2_k127_3885207_1 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008612 294.0
TLS2_k127_3885207_10 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000007384 126.0
TLS2_k127_3885207_11 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.00000000000000000000003388 112.0
TLS2_k127_3885207_12 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000001845 90.0
TLS2_k127_3885207_13 Protein of unknown function (DUF559) - - - 0.00000000000000449 80.0
TLS2_k127_3885207_14 - - - - 0.00000000000004554 78.0
TLS2_k127_3885207_15 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000006944 66.0
TLS2_k127_3885207_16 - - - - 0.00000000008937 72.0
TLS2_k127_3885207_17 CopG antitoxin of type II toxin-antitoxin system - - - 0.00008218 50.0
TLS2_k127_3885207_18 Peptidase M10A and M12B matrixin and adamalysin - - - 0.0003838 53.0
TLS2_k127_3885207_2 Glycoside hydrolase family 3 domain protein K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000004535 274.0
TLS2_k127_3885207_3 Binding-protein-dependent transport system inner membrane component K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002724 266.0
TLS2_k127_3885207_4 Metallo-beta-lactamase superfamily K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000004713 218.0
TLS2_k127_3885207_5 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000001235 218.0
TLS2_k127_3885207_6 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000004474 190.0
TLS2_k127_3885207_7 ATP-NAD kinase K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000008179 191.0
TLS2_k127_3885207_8 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000004285 171.0
TLS2_k127_3885207_9 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000001678 153.0
TLS2_k127_3905314_0 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 GO:0003674,GO:0005215,GO:0005372,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0006884,GO:0006950,GO:0006970,GO:0008150,GO:0008361,GO:0009628,GO:0009987,GO:0009992,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042044,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0050896,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 346.0
TLS2_k127_3905314_1 LssY C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000003172 229.0
TLS2_k127_3905314_2 - - - - 0.00000000000000000000000000000000000000004089 155.0
TLS2_k127_3905314_3 serine-type aminopeptidase activity - - - 0.0000000000000000000000000000000000001029 153.0
TLS2_k127_3905314_4 PFAM lipase class 3 K01046 - 3.1.1.3 0.00000000000000000000000000000001919 139.0
TLS2_k127_3910339_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007599 625.0
TLS2_k127_3910339_1 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 587.0
TLS2_k127_3910339_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 316.0
TLS2_k127_3910339_3 regulation of translation K03530 - - 0.0000000000000000000000000000000000001534 143.0
TLS2_k127_3910339_4 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.00000000000000000000000000000000004041 141.0
TLS2_k127_3910339_5 outer membrane efflux protein - - - 0.000008071 55.0
TLS2_k127_3926641_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1099.0
TLS2_k127_3926641_1 Type III secretion protein K03230 - - 6.346e-217 695.0
TLS2_k127_3926641_2 AAA ATPase, central domain protein K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 454.0
TLS2_k127_3926641_3 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 340.0
TLS2_k127_3926641_4 May be involved in recombinational repair of damaged DNA K03631 GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 319.0
TLS2_k127_3926641_5 Peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009967 284.0
TLS2_k127_3926641_6 protein phosphatase 2C domain protein K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000001159 244.0
TLS2_k127_3926641_7 Domain of unknown function (DUF1287) K09974 - - 0.000000000000000000000000000000000000000000000000000000000000000001856 232.0
TLS2_k127_3926641_8 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000007052 207.0
TLS2_k127_3926641_9 NAD FAD-binding protein K06954 - - 0.0000000000001079 81.0
TLS2_k127_393074_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601,K03797 - 3.1.11.6,3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 359.0
TLS2_k127_393074_1 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 346.0
TLS2_k127_393074_2 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000001503 177.0
TLS2_k127_393074_3 B12 binding domain - - - 0.000000000000000000000000000000000000000000002807 175.0
TLS2_k127_393074_4 Pkd domain containing protein - - - 0.000000000000000000386 100.0
TLS2_k127_393074_5 exodeoxyribonuclease VII activity K03602 - 3.1.11.6 0.000000002036 61.0
TLS2_k127_393074_6 Phosphoglycerate mutase family K08296 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564 - 0.00000003922 61.0
TLS2_k127_3948957_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 594.0
TLS2_k127_3948957_1 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 533.0
TLS2_k127_3948957_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006588 294.0
TLS2_k127_3948957_3 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000006145 161.0
TLS2_k127_3948957_4 domain, Protein K00703,K07082 - 2.4.1.21 0.000000000000000005723 91.0
TLS2_k127_3955282_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 9.519e-195 614.0
TLS2_k127_3955282_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 387.0
TLS2_k127_3955282_10 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000551 170.0
TLS2_k127_3955282_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 338.0
TLS2_k127_3955282_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 300.0
TLS2_k127_3955282_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 293.0
TLS2_k127_3955282_5 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002518 289.0
TLS2_k127_3955282_6 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000865 281.0
TLS2_k127_3955282_7 Choline/ethanolamine kinase K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000006617 273.0
TLS2_k127_3955282_8 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003111 284.0
TLS2_k127_3955282_9 Nucleotidyl transferase K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000007938 175.0
TLS2_k127_4022263_0 PFAM HypF finger K04656 - - 1.696e-263 831.0
TLS2_k127_4022263_1 Nickel-dependent hydrogenase - - - 1.795e-206 650.0
TLS2_k127_4022263_10 Hydrogenase maturation protease - - - 0.000000000000000000000000000000000002347 145.0
TLS2_k127_4022263_11 DnaJ molecular chaperone homology domain K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.0000000000000000000000000000004168 126.0
TLS2_k127_4022263_12 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000002041 125.0
TLS2_k127_4022263_13 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000003562 111.0
TLS2_k127_4022263_14 Helix-turn-helix XRE-family like proteins K21498 - - 0.0000000000000000000000002727 108.0
TLS2_k127_4022263_15 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000004238 108.0
TLS2_k127_4022263_16 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.0000000000000000000000006832 105.0
TLS2_k127_4022263_17 Hydrogenase/urease nickel incorporation, metallochaperone, hypA - - - 0.00000000000000000007823 91.0
TLS2_k127_4022263_18 Belongs to the peptidase S8 family - - - 0.00000000000341 77.0
TLS2_k127_4022263_19 - - - - 0.0000000003787 61.0
TLS2_k127_4022263_2 hydrogenase expression formation protein K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 542.0
TLS2_k127_4022263_20 COG3420 Nitrous oxidase accessory protein - - - 0.0003714 55.0
TLS2_k127_4022263_3 Aldo/keto reductase family K16950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 527.0
TLS2_k127_4022263_4 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 473.0
TLS2_k127_4022263_5 deaminase activity K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 451.0
TLS2_k127_4022263_6 coenzyme F420 hydrogenase activity K18007 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 406.0
TLS2_k127_4022263_7 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 332.0
TLS2_k127_4022263_8 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000001424 215.0
TLS2_k127_4022263_9 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000003711 170.0
TLS2_k127_4057104_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 576.0
TLS2_k127_4057104_1 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 491.0
TLS2_k127_4057104_10 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000001427 273.0
TLS2_k127_4057104_11 FlhB HrpN YscU SpaS Family K02401 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002367 263.0
TLS2_k127_4057104_12 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000004801 211.0
TLS2_k127_4057104_13 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000001342 218.0
TLS2_k127_4057104_14 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000001571 203.0
TLS2_k127_4057104_15 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000001272 199.0
TLS2_k127_4057104_16 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000007867 207.0
TLS2_k127_4057104_17 SAM-dependent RNA methyltransferase - - - 0.000000000000000000000000000000000000000000000000007762 190.0
TLS2_k127_4057104_18 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000001678 154.0
TLS2_k127_4057104_19 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000001723 155.0
TLS2_k127_4057104_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 479.0
TLS2_k127_4057104_20 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000008614 137.0
TLS2_k127_4057104_21 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000004856 130.0
TLS2_k127_4057104_22 YceI-like domain - - - 0.000000000000000000000000001143 123.0
TLS2_k127_4057104_23 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000003091 107.0
TLS2_k127_4057104_24 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749 - - 0.0000000000000002858 83.0
TLS2_k127_4057104_25 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000008222 84.0
TLS2_k127_4057104_26 COG1233 Phytoene dehydrogenase and related - - - 0.000000000000002233 89.0
TLS2_k127_4057104_27 Cytosol aminopeptidase family, N-terminal domain - - - 0.000000000000004969 81.0
TLS2_k127_4057104_28 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000001423 75.0
TLS2_k127_4057104_29 Protein of unknown function (DUF456) K09793 - - 0.0000000000005191 76.0
TLS2_k127_4057104_3 two component, sigma54 specific, transcriptional regulator, Fis family K07713,K07714,K07715 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 415.0
TLS2_k127_4057104_30 Outer membrane protein beta-barrel domain - - - 0.00007186 53.0
TLS2_k127_4057104_31 Acyltransferase K00655 - 2.3.1.51 0.0009492 54.0
TLS2_k127_4057104_4 AIR synthase related protein domain protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 382.0
TLS2_k127_4057104_5 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 367.0
TLS2_k127_4057104_6 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 368.0
TLS2_k127_4057104_7 pfam abc K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 350.0
TLS2_k127_4057104_8 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002091 287.0
TLS2_k127_4057104_9 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005161 299.0
TLS2_k127_4061336_0 Sulfite reductase K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 1.147e-284 894.0
TLS2_k127_4061336_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.176e-245 769.0
TLS2_k127_4061336_2 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 368.0
TLS2_k127_4061336_3 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 333.0
TLS2_k127_4061336_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018 - 1.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002319 281.0
TLS2_k127_4061336_5 Rhodanese Homology Domain - - - 0.00000000000000000000000000005168 125.0
TLS2_k127_4061336_6 - - - - 0.00000000000000000000000008473 115.0
TLS2_k127_4061336_7 Bacterial protein of unknown function (DUF937) - - - 0.00000000000001016 77.0
TLS2_k127_4061336_8 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - 0.0000002889 54.0
TLS2_k127_4061336_9 Bacterial protein of unknown function (DUF937) - - - 0.0008049 50.0
TLS2_k127_4095081_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 476.0
TLS2_k127_4095081_1 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 400.0
TLS2_k127_4095081_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 398.0
TLS2_k127_4095081_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000001114 203.0
TLS2_k127_4095081_4 Tetratricopeptide repeats - - - 0.000000000000000000000000000003602 130.0
TLS2_k127_4095081_5 PFAM helix-turn-helix domain protein - - - 0.0000000000000000001353 91.0
TLS2_k127_410821_0 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 368.0
TLS2_k127_410821_1 domain, Protein K01179,K07260,K13735 - 3.2.1.4,3.4.17.14 0.000000000000000000000001978 119.0
TLS2_k127_410821_2 Thrombospondin type 3 - - - 0.00000000000000000001652 107.0
TLS2_k127_410821_3 lipopolysaccharide metabolic process K08309,K19804 - - 0.00001562 57.0
TLS2_k127_4119761_0 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 1.24e-226 717.0
TLS2_k127_4119761_1 dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes K13356 - 1.2.1.84 3.265e-211 686.0
TLS2_k127_4119761_2 Domain of unknown function (DUF4172) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 477.0
TLS2_k127_4119761_3 epimerase dehydratase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 304.0
TLS2_k127_4119761_4 FAD dependent oxidoreductase K07137 - - 0.00000000000000000000000000000000000000000000000000000000000000001953 233.0
TLS2_k127_4119761_5 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000002548 128.0
TLS2_k127_4120741_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 1.075e-202 637.0
TLS2_k127_4120741_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 517.0
TLS2_k127_4120741_10 Capsular polysaccharide synthesis protein - - - 0.00000000000000000006804 100.0
TLS2_k127_4120741_11 Acetyltransferase (GNAT) domain K00657,K00663 - 2.3.1.57,2.3.1.82 0.00000000000000001626 93.0
TLS2_k127_4120741_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000002553 66.0
TLS2_k127_4120741_2 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 424.0
TLS2_k127_4120741_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 407.0
TLS2_k127_4120741_4 D-ala D-ala ligase N-terminus K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 307.0
TLS2_k127_4120741_5 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007815 253.0
TLS2_k127_4120741_6 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000002323 230.0
TLS2_k127_4120741_7 Uncharacterised protein family (UPF0093) K08973 - - 0.00000000000000000000000000000000000000006243 156.0
TLS2_k127_4120741_8 Essential cell division protein K03589 - - 0.000000000000000000000000002701 123.0
TLS2_k127_4120741_9 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000009704 121.0
TLS2_k127_4167594_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.87e-322 1020.0
TLS2_k127_4167594_1 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000001511 173.0
TLS2_k127_4167594_2 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000001189 136.0
TLS2_k127_4167594_3 PFAM Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000003132 107.0
TLS2_k127_4167594_4 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.000000000001084 76.0
TLS2_k127_4173706_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1226.0
TLS2_k127_4173706_1 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000005515 200.0
TLS2_k127_4173706_2 RNA-directed DNA polymerase (Reverse transcriptase) - - - 0.0000000000000000000000003745 110.0
TLS2_k127_4173706_3 Reverse transcriptase (RNA-dependent DNA polymerase) K00986 - 2.7.7.49 0.0000000000000000000000007866 109.0
TLS2_k127_4173706_4 23S rRNA-intervening sequence protein - - - 0.00000000000000000005391 94.0
TLS2_k127_4173706_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000001491 79.0
TLS2_k127_4173706_6 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.0000000004093 63.0
TLS2_k127_4173706_7 PFAM Sulphatase-modifying factor - - - 0.00004051 55.0
TLS2_k127_4173706_8 Sulfatase-modifying factor enzyme 1 - - - 0.000173 47.0
TLS2_k127_4191984_0 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 2.553e-262 838.0
TLS2_k127_4191984_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 531.0
TLS2_k127_4191984_2 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 396.0
TLS2_k127_4191984_3 Acyl CoA binding protein - - - 0.0000000000000000001475 90.0
TLS2_k127_4242569_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009434 496.0
TLS2_k127_4242569_1 Histidinol dehydrogenase K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 435.0
TLS2_k127_4242569_2 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 393.0
TLS2_k127_4242569_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000526 246.0
TLS2_k127_4242569_4 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000002173 197.0
TLS2_k127_4242569_5 methyltransferase - - - 0.000000000000000000000001653 113.0
TLS2_k127_426348_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 2.57e-221 700.0
TLS2_k127_426348_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003912 608.0
TLS2_k127_426348_10 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000002016 224.0
TLS2_k127_426348_11 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000001199 215.0
TLS2_k127_426348_12 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000001995 177.0
TLS2_k127_426348_13 TIGRFAM Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000001716 160.0
TLS2_k127_426348_14 PFAM Peptidase M22, glycoprotease K01409,K14742 - 2.3.1.234 0.000000000000000000000000000000002849 138.0
TLS2_k127_426348_16 Protein of unknown function (DUF465) K09794 - - 0.00009244 50.0
TLS2_k127_426348_17 repeat-containing protein - - - 0.0007574 51.0
TLS2_k127_426348_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007598 463.0
TLS2_k127_426348_3 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 441.0
TLS2_k127_426348_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 325.0
TLS2_k127_426348_5 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 319.0
TLS2_k127_426348_6 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004073 298.0
TLS2_k127_426348_7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004297 284.0
TLS2_k127_426348_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000002491 276.0
TLS2_k127_426348_9 e3 binding domain K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000033 242.0
TLS2_k127_4276291_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 4.128e-285 897.0
TLS2_k127_4276291_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 604.0
TLS2_k127_4276291_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 565.0
TLS2_k127_4276291_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 305.0
TLS2_k127_4276291_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000003573 98.0
TLS2_k127_4276291_5 RIO1 family K01090,K12132 - 2.7.11.1,3.1.3.16 0.000002731 53.0
TLS2_k127_437988_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 386.0
TLS2_k127_437988_1 Protein of unknown function, DUF547 - - - 0.00000000000000000000000000000000734 140.0
TLS2_k127_437988_2 Domain of unknown function (DUF4911) - - - 0.0000001183 56.0
TLS2_k127_437988_3 - - - - 0.00003284 48.0
TLS2_k127_4391396_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1140.0
TLS2_k127_4391396_1 TrkA-C domain K03455 - - 4.828e-249 788.0
TLS2_k127_4391396_10 macrolide-specific efflux protein K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 293.0
TLS2_k127_4391396_11 Bacterial trigger factor protein (TF) C-terminus K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003403 283.0
TLS2_k127_4391396_12 O-methyltransferase K21460 - 2.1.1.304 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008324 276.0
TLS2_k127_4391396_13 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009695 249.0
TLS2_k127_4391396_14 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000001161 236.0
TLS2_k127_4391396_15 FusA NodT family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002127 240.0
TLS2_k127_4391396_16 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000434 224.0
TLS2_k127_4391396_17 peroxiredoxin activity K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.00000000000000000000000000000000000000000000000000009907 190.0
TLS2_k127_4391396_18 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000008557 184.0
TLS2_k127_4391396_19 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000002615 196.0
TLS2_k127_4391396_2 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 3.712e-225 732.0
TLS2_k127_4391396_20 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000001505 188.0
TLS2_k127_4391396_21 - - - - 0.00000000000000000000000000000000000000001285 167.0
TLS2_k127_4391396_22 Oxidoreductase - - - 0.000000000000000000000000000000000005142 153.0
TLS2_k127_4391396_23 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000013 139.0
TLS2_k127_4391396_24 COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase - - - 0.000000000000000003842 98.0
TLS2_k127_4391396_25 Acts as a magnesium transporter K04767,K06213,K15986 - 3.6.1.1 0.0000000000001202 81.0
TLS2_k127_4391396_27 COG0668 Small-conductance mechanosensitive channel - - - 0.000000000004643 70.0
TLS2_k127_4391396_28 Thrombospondin type 3 repeat - - - 0.00000009232 64.0
TLS2_k127_4391396_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 610.0
TLS2_k127_4391396_30 - - - - 0.000002799 53.0
TLS2_k127_4391396_31 CsbD-like - - - 0.00001795 48.0
TLS2_k127_4391396_32 Phage integrase family - - - 0.0002316 45.0
TLS2_k127_4391396_4 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003724 473.0
TLS2_k127_4391396_5 domain protein K21029,K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 467.0
TLS2_k127_4391396_6 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007842 417.0
TLS2_k127_4391396_7 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 402.0
TLS2_k127_4391396_8 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 367.0
TLS2_k127_4391396_9 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 319.0
TLS2_k127_440522_0 Carboxyl transferase domain K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 3.72e-245 766.0
TLS2_k127_440522_1 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 605.0
TLS2_k127_440522_2 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 487.0
TLS2_k127_440522_3 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 432.0
TLS2_k127_440522_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.00000000000000000000000000000000000000001134 158.0
TLS2_k127_440522_5 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.00000000000000000000001457 102.0
TLS2_k127_440522_6 P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein - - - 0.000009392 54.0
TLS2_k127_4428372_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003195 273.0
TLS2_k127_4428372_1 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003387 271.0
TLS2_k127_4428372_2 Metallo-beta-lactamase superfamily K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000005895 259.0
TLS2_k127_4428372_3 COGs COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000004291 229.0
TLS2_k127_4428372_4 Zn-dependent hydrolase, glyoxylase - - - 0.0000000000000000000000000000000000000000004066 170.0
TLS2_k127_4428372_5 NUDIX domain - - - 0.00000000000000000000000000000000000000008843 157.0
TLS2_k127_4428372_6 Cysteine sulfinate desulfinase cysteine desulfurase K04487 - 2.8.1.7 0.000000008589 59.0
TLS2_k127_4552372_0 Shikimate dehydrogenase substrate binding domain K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000005889 227.0
TLS2_k127_4581040_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1213.0
TLS2_k127_4581040_1 Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 473.0
TLS2_k127_4581040_10 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 302.0
TLS2_k127_4581040_11 TolB amino-terminal domain K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006611 288.0
TLS2_k127_4581040_12 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009107 265.0
TLS2_k127_4581040_13 ATPase-coupled sulfate transmembrane transporter activity K02047 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000006435 253.0
TLS2_k127_4581040_14 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000003109 194.0
TLS2_k127_4581040_15 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000006271 181.0
TLS2_k127_4581040_16 PFAM MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000001919 179.0
TLS2_k127_4581040_17 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000005803 175.0
TLS2_k127_4581040_18 Ppx GppA K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000001048 171.0
TLS2_k127_4581040_19 Transcriptional regulator K13643 - - 0.0000000000000000000000000000000000000001475 154.0
TLS2_k127_4581040_2 Transketolase K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 376.0
TLS2_k127_4581040_20 Protein of unknown function (DUF3829) - - - 0.0000000000000000000000000000000000004295 154.0
TLS2_k127_4581040_21 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.00000000000000000000000000000005439 129.0
TLS2_k127_4581040_22 ATPase (AAA superfamily - - - 0.0000000000000000000000000000001463 128.0
TLS2_k127_4581040_23 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000000002899 132.0
TLS2_k127_4581040_24 Protein of unknown function (DUF3047) - - - 0.00000000000000000000002565 109.0
TLS2_k127_4581040_25 Ferric uptake regulator family K03711,K09825 GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141 - 0.000000000000000000000176 103.0
TLS2_k127_4581040_26 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000003796 89.0
TLS2_k127_4581040_27 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000005057 76.0
TLS2_k127_4581040_28 TonB C terminal K03832 - - 0.000009277 57.0
TLS2_k127_4581040_3 Acyl-CoA dehydrogenase, middle domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 369.0
TLS2_k127_4581040_4 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 362.0
TLS2_k127_4581040_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 374.0
TLS2_k127_4581040_6 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 347.0
TLS2_k127_4581040_7 Transketolase K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 330.0
TLS2_k127_4581040_8 Sulfate ABC transporter periplasmic sulfate-binding protein K02048 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 332.0
TLS2_k127_4581040_9 ATPase-coupled sulfate transmembrane transporter activity K02046,K02047 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007798 321.0
TLS2_k127_462585_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 1.333e-256 800.0
TLS2_k127_462585_1 carbamoyl transferase, NodU family K00612 - - 6.26e-256 801.0
TLS2_k127_462585_10 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002575 272.0
TLS2_k127_462585_11 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000005111 260.0
TLS2_k127_462585_12 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003891 251.0
TLS2_k127_462585_13 enoyl-CoA hydratase K13766,K15312 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000006633 245.0
TLS2_k127_462585_14 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000001715 230.0
TLS2_k127_462585_15 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000003138 211.0
TLS2_k127_462585_16 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000001458 217.0
TLS2_k127_462585_17 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000009327 202.0
TLS2_k127_462585_18 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000001309 196.0
TLS2_k127_462585_19 Fic/DOC family N-terminal - GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046983,GO:0070566,GO:0070733,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - 0.000000000000000000000000000000000000000000000000002586 188.0
TLS2_k127_462585_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 5.921e-216 692.0
TLS2_k127_462585_20 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - 0.0000000000000000000000000000000000000000001281 165.0
TLS2_k127_462585_21 Methyltransferase K15460 - 2.1.1.223 0.0000000000000000000000000000000000000000004056 167.0
TLS2_k127_462585_22 Telomere recombination K07566 - 2.7.7.87 0.000000000000000000000000000000003977 135.0
TLS2_k127_462585_23 Zincin-like metallopeptidase - - - 0.00000000000000000000000000001947 121.0
TLS2_k127_462585_24 - - - - 0.0000000000000000000000000001326 123.0
TLS2_k127_462585_25 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.0000000000000000006702 92.0
TLS2_k127_462585_26 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000003644 83.0
TLS2_k127_462585_27 - - - - 0.0000000000000007812 83.0
TLS2_k127_462585_28 - - - - 0.00000000000006973 72.0
TLS2_k127_462585_29 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009636,GO:0009987,GO:0010496,GO:0010497,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0030234,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0097237,GO:0098754,GO:0098772,GO:0098869,GO:1990748 - 0.000009669 59.0
TLS2_k127_462585_3 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 523.0
TLS2_k127_462585_4 Carbamoyl-phosphate synthetase large chain domain protein K01968 - 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006902 483.0
TLS2_k127_462585_5 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009761 376.0
TLS2_k127_462585_6 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003897 364.0
TLS2_k127_462585_7 HMGL-like K01640 GO:0003674,GO:0003824,GO:0004419,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 340.0
TLS2_k127_462585_8 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005018 339.0
TLS2_k127_462585_9 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 331.0
TLS2_k127_4647386_0 Mur ligase, middle domain K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 447.0
TLS2_k127_4647386_1 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 415.0
TLS2_k127_4647386_10 phosphoesterase DHHA1 - - - 0.00000000000000000000000000000000009052 143.0
TLS2_k127_4647386_11 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000003781 106.0
TLS2_k127_4647386_12 CAAX protease self-immunity K07052 - - 0.0000000000908 73.0
TLS2_k127_4647386_13 4Fe-4S binding domain K03616 - - 0.0000000001376 68.0
TLS2_k127_4647386_14 YceI-like domain - - - 0.0000000003249 69.0
TLS2_k127_4647386_15 Beta-propeller repeat - - - 0.000001684 57.0
TLS2_k127_4647386_2 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 413.0
TLS2_k127_4647386_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 348.0
TLS2_k127_4647386_4 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 341.0
TLS2_k127_4647386_5 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 302.0
TLS2_k127_4647386_6 PFAM Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006935 250.0
TLS2_k127_4647386_7 LD-carboxypeptidase K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000000000000006813 227.0
TLS2_k127_4647386_8 converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - 0.0000000000000000000000000000000000000000000000000000000000009856 215.0
TLS2_k127_4647386_9 Major intrinsic protein K02440 - - 0.000000000000000000000000000000000000000000000000000000000005235 231.0
TLS2_k127_4663596_0 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 388.0
TLS2_k127_4687652_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 1.106e-198 631.0
TLS2_k127_4687652_1 helicase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 579.0
TLS2_k127_4687652_10 polysaccharide export K01991 - - 0.000000006506 64.0
TLS2_k127_4687652_2 Glycosyl Transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 467.0
TLS2_k127_4687652_3 PFAM glycoside hydrolase family 39 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 437.0
TLS2_k127_4687652_4 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 304.0
TLS2_k127_4687652_6 Capsule assembly protein Wzi - - - 0.00000000000000000000000000000000000005044 162.0
TLS2_k127_4687652_7 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000168 136.0
TLS2_k127_4687652_8 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000001485 134.0
TLS2_k127_4687652_9 extracellular polysaccharide biosynthetic process K01153,K05789,K07011,K16554 - 3.1.21.3 0.00000000000000000000008457 111.0
TLS2_k127_4696394_0 acyl-CoA dehydrogenase K14448 - 1.3.8.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 548.0
TLS2_k127_4696394_1 N-terminal half of MaoC dehydratase K14449 - 4.2.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 433.0
TLS2_k127_4780494_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1332.0
TLS2_k127_4780494_1 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 1.187e-219 696.0
TLS2_k127_4780494_10 tRNA wobble cytosine modification - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009566 252.0
TLS2_k127_4780494_11 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000001222 192.0
TLS2_k127_4780494_12 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000131 138.0
TLS2_k127_4780494_13 Phosphodiester glycosidase - - - 0.0000000000000000000000000000004101 133.0
TLS2_k127_4780494_14 Universal stress protein family - - - 0.000000000000000000000000000002616 130.0
TLS2_k127_4780494_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000001656 96.0
TLS2_k127_4780494_16 Lactonase, 7-bladed beta-propeller - - - 0.0001539 53.0
TLS2_k127_4780494_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 5.525e-218 686.0
TLS2_k127_4780494_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 547.0
TLS2_k127_4780494_4 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005406 543.0
TLS2_k127_4780494_5 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 533.0
TLS2_k127_4780494_6 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 531.0
TLS2_k127_4780494_7 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 465.0
TLS2_k127_4780494_8 SPFH domain-Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 392.0
TLS2_k127_4780494_9 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 286.0
TLS2_k127_4790838_0 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 324.0
TLS2_k127_4790838_1 tigr02147 - - - 0.00000000000000000000000000000001068 137.0
TLS2_k127_4790838_2 PFAM Beta propeller domain K14475 - - 0.000000000000000000000002825 119.0
TLS2_k127_4790838_3 Protein of unknown function (DUF3494) - - - 0.0000000009938 63.0
TLS2_k127_4831697_0 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 292.0
TLS2_k127_4831697_1 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000001395 105.0
TLS2_k127_4831697_2 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000001767 113.0
TLS2_k127_4831697_3 Protein of unknown function (DUF3592) - - - 0.000000000000006385 81.0
TLS2_k127_4831697_4 guanyl-nucleotide exchange factor activity K01387,K07114,K12287 - 3.4.24.3 0.00000000000004467 85.0
TLS2_k127_4831697_5 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0000004852 53.0
TLS2_k127_490102_0 Protein of unknown function (DUF933) K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 467.0
TLS2_k127_490102_1 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 299.0
TLS2_k127_490102_2 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.00000000000000000000000000000000000000001029 164.0
TLS2_k127_490102_3 TPM domain K06872 - - 0.0000000000000000000000000000000000000003112 165.0
TLS2_k127_4922066_0 von Willebrand factor type A domain K07114 - - 0.0000000000000000000000000000000000000004686 168.0
TLS2_k127_5047073_0 TIGRFAM ATPase, FliI YscN family K02412,K03224 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 526.0
TLS2_k127_5047073_1 Belongs to the sigma-70 factor family K02405 - - 0.000000000000000000000000000000000000000002024 165.0
TLS2_k127_5047073_2 Secretory protein of YscJ/FliF family K03222 - - 0.0000000000000000000000000002942 126.0
TLS2_k127_5047073_3 flagellar assembly protein FliH K02411 - - 0.00000000000000000001653 100.0
TLS2_k127_5047073_4 YscO-like protein - - - 0.000000000006737 72.0
TLS2_k127_5047073_5 Tetratricopeptide repeat - - - 0.0000006321 57.0
TLS2_k127_5049682_0 PFAM Radical SAM K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 595.0
TLS2_k127_5049682_1 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 465.0
TLS2_k127_5049682_10 Protein conserved in bacteria K09986 - - 0.0000000000000005189 86.0
TLS2_k127_5049682_11 surface antigen K07278 - - 0.000000000000000701 87.0
TLS2_k127_5049682_12 - - - - 0.00000000000002891 75.0
TLS2_k127_5049682_13 Cytochrome oxidase complex assembly protein 1 - - - 0.00004505 55.0
TLS2_k127_5049682_2 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000643 363.0
TLS2_k127_5049682_3 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 339.0
TLS2_k127_5049682_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 320.0
TLS2_k127_5049682_5 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 304.0
TLS2_k127_5049682_6 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001313 261.0
TLS2_k127_5049682_7 PFAM DSBA oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000009691 201.0
TLS2_k127_5049682_8 OsmC-like protein K06889,K07397 - - 0.000000000000000000000000000000000000000002786 160.0
TLS2_k127_5049682_9 nUDIX hydrolase K03574,K03575 - 3.6.1.55 0.0000000000000000000000000006295 117.0
TLS2_k127_5050604_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006137 321.0
TLS2_k127_5050604_1 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002016 241.0
TLS2_k127_5050604_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000001721 121.0
TLS2_k127_5050604_3 Bacterial regulatory protein, Fis family K07713 - - 0.00000269 55.0
TLS2_k127_5053625_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 610.0
TLS2_k127_5053625_1 Glutaredoxin K05309 - 5.3.99.3 0.00000000000000000000000000000000000000000000000000000004325 204.0
TLS2_k127_5053625_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.00000000000000000000000000000000000000000000002056 181.0
TLS2_k127_5053625_3 Belongs to the BolA IbaG family K05527 - - 0.00000000000000000000000009198 109.0
TLS2_k127_5053625_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000004489 84.0
TLS2_k127_5102153_0 DeoC/LacD family aldolase K11645 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 567.0
TLS2_k127_5102153_1 Protein of unknown function (DUF1016) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 433.0
TLS2_k127_5102153_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01524,K07012 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 435.0
TLS2_k127_5102153_3 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 289.0
TLS2_k127_5102153_4 WYL domain K13573 - - 0.00000000000000000000000000000000000000000000000000000000000000000001473 245.0
TLS2_k127_5102153_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000259 241.0
TLS2_k127_5102153_6 Phosphoglycerate mutase family - - - 0.0000000000000000000006886 101.0
TLS2_k127_5102153_7 Tetratricopeptide repeat - - - 0.00000001729 65.0
TLS2_k127_5102153_8 CHAD - - - 0.000128 53.0
TLS2_k127_5107449_0 Bacterial regulatory protein, Fis family K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 330.0
TLS2_k127_5110132_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 556.0
TLS2_k127_5110132_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002908 277.0
TLS2_k127_5110132_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000052 255.0
TLS2_k127_5110132_3 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000000000000000001704 156.0
TLS2_k127_5110132_4 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.000000000000000000000000000000000000000004259 166.0
TLS2_k127_5110132_5 Membrane proteins related to metalloendopeptidases K06194 - - 0.00000000000000000000000000000000000001577 150.0
TLS2_k127_5110132_6 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000019 120.0
TLS2_k127_5110132_7 DoxX-like family - - - 0.0000000000000000000000000004311 121.0
TLS2_k127_5110132_8 PFAM Rhodanese domain protein - - - 0.0000000000000000000006735 99.0
TLS2_k127_5113320_0 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 421.0
TLS2_k127_5113320_1 Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007356 296.0
TLS2_k127_5113320_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000005677 262.0
TLS2_k127_5113320_3 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000001811 254.0
TLS2_k127_5113320_4 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000345 172.0
TLS2_k127_5113320_5 PAS domain - - - 0.0000000000000000000000000000000000000000007513 181.0
TLS2_k127_5113320_6 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000003706 121.0
TLS2_k127_5177501_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 7.494e-249 782.0
TLS2_k127_5177501_1 PFAM thiamine pyrophosphate protein TPP binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 461.0
TLS2_k127_5177501_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 436.0
TLS2_k127_5177501_3 PFAM ThiJ PfpI domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 297.0
TLS2_k127_5177501_4 Peroxiredoxin K13279,K20011 GO:0000003,GO:0000302,GO:0001890,GO:0001893,GO:0002237,GO:0002376,GO:0002520,GO:0003006,GO:0003674,GO:0003824,GO:0004601,GO:0004857,GO:0004866,GO:0004869,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005768,GO:0005769,GO:0005829,GO:0006355,GO:0006464,GO:0006807,GO:0006915,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0007275,GO:0007565,GO:0008022,GO:0008150,GO:0008152,GO:0008219,GO:0008284,GO:0008379,GO:0008785,GO:0009056,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009889,GO:0009892,GO:0009987,GO:0010033,GO:0010035,GO:0010466,GO:0010468,GO:0010556,GO:0010563,GO:0010605,GO:0010941,GO:0010951,GO:0012501,GO:0012505,GO:0016043,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0018158,GO:0018171,GO:0018193,GO:0018198,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0022414,GO:0030097,GO:0030099,GO:0030154,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0031326,GO:0031410,GO:0031974,GO:0031982,GO:0032268,GO:0032269,GO:0032496,GO:0032501,GO:0032502,GO:0032504,GO:0032991,GO:0033554,GO:0033673,GO:0033993,GO:0034599,GO:0034614,GO:0036211,GO:0042127,GO:0042221,GO:0042325,GO:0042326,GO:0042391,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0042802,GO:0042981,GO:0043027,GO:0043028,GO:0043066,GO:0043067,GO:0043069,GO:0043086,GO:0043154,GO:0043170,GO:0043207,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043281,GO:0043412,GO:0043523,GO:0043524,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0045861,GO:0045936,GO:0046677,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048608,GO:0048609,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051090,GO:0051091,GO:0051092,GO:0051171,GO:0051172,GO:0051174,GO:0051186,GO:0051187,GO:0051246,GO:0051248,GO:0051252,GO:0051336,GO:0051338,GO:0051346,GO:0051348,GO:0051704,GO:0051707,GO:0051716,GO:0051881,GO:0051920,GO:0052547,GO:0052548,GO:0055114,GO:0060135,GO:0060255,GO:0060548,GO:0061134,GO:0061135,GO:0061458,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070887,GO:0071704,GO:0071840,GO:0072593,GO:0080090,GO:0097237,GO:0097708,GO:0098754,GO:0098772,GO:0098869,GO:1901214,GO:1901215,GO:1901564,GO:1901700,GO:1901701,GO:1903506,GO:1990748,GO:2000112,GO:2000116,GO:2000117,GO:2001141 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008019 276.0
TLS2_k127_5177501_5 - - - - 0.0000000000000000000000000000000000000007275 168.0
TLS2_k127_5177501_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000007682 124.0
TLS2_k127_5177501_8 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K03294 - - 0.0006535 49.0
TLS2_k127_5252190_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.304e-236 747.0
TLS2_k127_5252190_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000007131 211.0
TLS2_k127_5252190_10 PFAM FecR protein K01387 - 3.4.24.3 0.00005315 56.0
TLS2_k127_5252190_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000632 162.0
TLS2_k127_5252190_3 Domain of unknown function (DUF309) K09763 - - 0.000000000000000000000000001643 126.0
TLS2_k127_5252190_4 Acid phosphatase homologues - - - 0.00000000000005634 81.0
TLS2_k127_5252190_5 PFAM Fibronectin type III domain - - - 0.0000000002696 74.0
TLS2_k127_5252190_6 PFAM phosphatidate cytidylyltransferase - - - 0.0000000002917 69.0
TLS2_k127_5252190_7 Protein of unknown function (DUF983) - - - 0.0000002179 58.0
TLS2_k127_5252190_8 Purple acid Phosphatase, N-terminal domain - - - 0.0000009576 63.0
TLS2_k127_5320582_0 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 441.0
TLS2_k127_5320582_1 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.0006943 52.0
TLS2_k127_5322328_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 440.0
TLS2_k127_5322328_1 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000009269 151.0
TLS2_k127_5341862_0 RelA SpoT domain protein K07816 - 2.7.6.5 0.0002343 56.0
TLS2_k127_5417626_0 Rod shape-determining protein K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 541.0
TLS2_k127_5417626_1 Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006548 342.0
TLS2_k127_5417626_2 Integral membrane protein - - - 0.000000000000000000000000000000000001294 150.0
TLS2_k127_5417626_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859,K07566 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,2.7.7.87 0.00000000000000000000000000000000003484 143.0
TLS2_k127_5417626_4 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000003637 146.0
TLS2_k127_5417626_5 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000002062 140.0
TLS2_k127_5417626_6 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000002135 81.0
TLS2_k127_5417626_7 peptidylprolyl isomerase K03770 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 0.0000000002508 72.0
TLS2_k127_543685_0 3-isopropylmalate dehydratase K01703,K17749 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 395.0
TLS2_k127_543685_1 Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001008 285.0
TLS2_k127_543685_2 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007543 278.0
TLS2_k127_543685_3 Acyl-protein synthetase, LuxE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006872 259.0
TLS2_k127_543685_4 belongs to the aldehyde dehydrogenase family K03400 - 1.2.1.50 0.000000000000000000000000000000000000000000000000000000000000000000003467 253.0
TLS2_k127_543685_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000001752 110.0
TLS2_k127_543685_6 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000295 69.0
TLS2_k127_5449437_0 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 1.439e-240 769.0
TLS2_k127_5449437_1 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 2.284e-240 755.0
TLS2_k127_5449437_2 Cytochrome c K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 567.0
TLS2_k127_5449437_3 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 492.0
TLS2_k127_5449437_4 Choloylglycine hydrolase K01442 - 3.5.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 418.0
TLS2_k127_5449437_5 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 398.0
TLS2_k127_5449437_6 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009484 257.0
TLS2_k127_5449437_7 exo-alpha-(2->6)-sialidase activity - - - 0.0000002944 63.0
TLS2_k127_5495199_0 YceG-like family K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000105 279.0
TLS2_k127_5495199_1 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000001812 102.0
TLS2_k127_5495199_2 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000002492 103.0
TLS2_k127_5495199_3 DcrB - - - 0.00008575 52.0
TLS2_k127_5527449_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1504.0
TLS2_k127_5527449_1 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 5.334e-210 667.0
TLS2_k127_5527449_10 Type II secretion system (T2SS), protein J K02459 - - 0.0000000000000000009851 94.0
TLS2_k127_5527449_11 type IV pilus modification protein PilV K02458 - - 0.000000000002257 75.0
TLS2_k127_5527449_12 general secretion pathway protein - - - 0.00000000004664 74.0
TLS2_k127_5527449_13 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.4.2.9 0.00000000461 58.0
TLS2_k127_5527449_14 Type II secretion system (T2SS), protein K K02460 - - 0.00000004236 65.0
TLS2_k127_5527449_15 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins - - - 0.0000001179 61.0
TLS2_k127_5527449_2 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 479.0
TLS2_k127_5527449_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 453.0
TLS2_k127_5527449_4 General secretion pathway protein F K02455,K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004798 409.0
TLS2_k127_5527449_5 Type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 372.0
TLS2_k127_5527449_6 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007599 347.0
TLS2_k127_5527449_7 Type IV pilus assembly protein PilM; K02461 - - 0.00000000000000000000000000000000000000000001534 181.0
TLS2_k127_5527449_8 PFAM type II secretion system protein G K02456 - - 0.00000000000000000000000000000000000003271 148.0
TLS2_k127_5527449_9 General secretion pathway protein C K02452 - - 0.00000000000000000001604 102.0
TLS2_k127_555821_0 Acyl-CoA dehydrogenase N terminal K09456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 512.0
TLS2_k127_555821_1 NmrA-like family K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004807 387.0
TLS2_k127_555821_2 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 339.0
TLS2_k127_555821_3 haloacid dehalogenase-like hydrolase K02203 - 2.7.1.39,3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000008424 262.0
TLS2_k127_555821_4 PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000004876 269.0
TLS2_k127_555821_5 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000002472 205.0
TLS2_k127_555821_6 - - - - 0.0000000000000005467 86.0
TLS2_k127_5563272_0 tail specific protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 532.0
TLS2_k127_5563272_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 518.0
TLS2_k127_5563272_10 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000196 98.0
TLS2_k127_5563272_11 Nucleotidyl transferase - - - 0.0000000000000000002114 97.0
TLS2_k127_5563272_12 Protein of unknown function (DUF1566) - - - 0.000000000003654 74.0
TLS2_k127_5563272_13 PFAM Haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000008425 70.0
TLS2_k127_5563272_14 Belongs to the peptidase S1B family - - - 0.000000567 61.0
TLS2_k127_5563272_15 - - - - 0.000004927 49.0
TLS2_k127_5563272_16 Conserved repeat domain - - - 0.00009391 54.0
TLS2_k127_5563272_2 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 485.0
TLS2_k127_5563272_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 431.0
TLS2_k127_5563272_4 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 371.0
TLS2_k127_5563272_5 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000697 250.0
TLS2_k127_5563272_6 TIGRFAM riboflavin biosynthesis protein RibF K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000003089 248.0
TLS2_k127_5563272_7 Belongs to the phosphoglycerate mutase family K02226,K22305 - 3.1.3.3,3.1.3.73 0.0000000000000000000000000000004652 130.0
TLS2_k127_5563272_8 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K01179 - 3.2.1.4 0.00000000000000000000000000001468 130.0
TLS2_k127_5563272_9 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000002063 103.0
TLS2_k127_5627192_0 Pectic acid lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 364.0
TLS2_k127_5627192_1 Pfam Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 348.0
TLS2_k127_5627192_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 327.0
TLS2_k127_5627192_3 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 308.0
TLS2_k127_5627192_4 uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 291.0
TLS2_k127_5627192_5 Predicted membrane protein (DUF2142) - - - 0.00000000000000000000000000000000000000000000000000000006196 224.0
TLS2_k127_5627192_6 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000002222 109.0
TLS2_k127_5627192_8 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.00000000000000000001405 104.0
TLS2_k127_5693577_0 Amidohydrolase family K20810 - 3.5.4.40 0.000000000000000000000000000000000000000000000000000005156 207.0
TLS2_k127_5693577_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000002424 189.0
TLS2_k127_5704033_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.656e-303 956.0
TLS2_k127_5704033_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 589.0
TLS2_k127_5704033_10 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.00000008707 60.0
TLS2_k127_5704033_2 Sodium/hydrogen exchanger family K11105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 504.0
TLS2_k127_5704033_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 418.0
TLS2_k127_5704033_4 PFAM methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 370.0
TLS2_k127_5704033_5 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001858 261.0
TLS2_k127_5704033_6 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000066 253.0
TLS2_k127_5704033_7 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000003499 177.0
TLS2_k127_5704033_8 Na Pi-cotransporter K03324 - - 0.0000000000000000000000000000000007615 134.0
TLS2_k127_5704033_9 RNA recognition motif - - - 0.00000000000000000000000002442 113.0
TLS2_k127_5732346_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 495.0
TLS2_k127_5732346_1 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 313.0
TLS2_k127_5732346_2 COG3264 Small-conductance mechanosensitive channel K22051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 305.0
TLS2_k127_5732346_3 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000001352 210.0
TLS2_k127_5732346_4 Carotenoid biosynthesis protein - - - 0.000000000000000000000000000000000000000000000001822 182.0
TLS2_k127_5732346_7 Thrombospondin type 3 - - - 0.000000000001066 80.0
TLS2_k127_5732346_8 alpha-L-arabinofuranosidase - - - 0.0002145 49.0
TLS2_k127_5734490_0 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 329.0
TLS2_k127_5734490_1 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000366 311.0
TLS2_k127_5734490_2 Catalyzes the synthesis of activated sulfate K00860,K00955 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001584 278.0
TLS2_k127_5734490_3 PFAM inositol monophosphatase - - - 0.000000000000000000000000000989 118.0
TLS2_k127_5734490_4 protein with SCP PR1 domains - - - 0.000000000000001333 86.0
TLS2_k127_5734490_5 Protein of unknown function (DUF2490) - - - 0.0001472 51.0
TLS2_k127_5833698_0 Tryptophan halogenase - - - 1.069e-196 629.0
TLS2_k127_5833698_1 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000001038 224.0
TLS2_k127_5833698_2 Bacterial extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000002077 202.0
TLS2_k127_5833698_3 DNA polymerase III K02341 - 2.7.7.7 0.0000000000000000007872 89.0
TLS2_k127_5873321_0 COG COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 1.988e-213 675.0
TLS2_k127_5873321_1 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 544.0
TLS2_k127_5873321_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 376.0
TLS2_k127_5873321_3 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009574 323.0
TLS2_k127_5873321_4 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000000008825 217.0
TLS2_k127_5873321_5 maF-like protein K03215,K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 2.1.1.190 0.00000000000000000000000000000000000000000001258 169.0
TLS2_k127_5873321_6 Protein of unknown function (DUF229) - - - 0.00000000000000000002083 108.0
TLS2_k127_5873321_7 Biotin-requiring enzyme - - - 0.00000000000007352 78.0
TLS2_k127_5873321_8 Outer membrane lipoprotein-sorting protein - - - 0.0000000003742 70.0
TLS2_k127_5899929_0 - - - - 0.0 1121.0
TLS2_k127_5899929_1 DNA photolyase activity K03716 - 4.1.99.14 0.000000000000000000000000000000000000000000000000000000000000000000000001419 258.0
TLS2_k127_5899929_2 chorismate binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000006072 251.0
TLS2_k127_5899929_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - 0.000000000000000000000000000000000000000000000000004709 188.0
TLS2_k127_5899929_4 Amino-transferase class IV K02619 - 4.1.3.38 0.0000000000000000000000000000001154 136.0
TLS2_k127_5899929_5 Psort location Cytoplasmic, score - - - 0.0001369 51.0
TLS2_k127_5899929_6 Nucleotidyl transferase AbiEii toxin, Type IV TA system K09144 - - 0.0002384 51.0
TLS2_k127_5927783_0 PFAM Glycosyl transferase, family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 3.135e-318 989.0
TLS2_k127_5927783_1 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006557 397.0
TLS2_k127_5927783_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 308.0
TLS2_k127_5927783_3 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009546 292.0
TLS2_k127_5927783_4 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000004698 236.0
TLS2_k127_5927783_5 Polymorphic membrane protein - - - 0.0000000000000000000000000000000000000003517 169.0
TLS2_k127_5927783_6 Bacterial regulatory proteins, tetR family K22041 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000003372 108.0
TLS2_k127_5927783_7 Belongs to the peptidase S26 family - - - 0.0000000007859 65.0
TLS2_k127_5927783_8 PFAM LIM, zinc-binding protein - - - 0.0000006108 60.0
TLS2_k127_593780_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 1.861e-198 624.0
TLS2_k127_593780_1 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 471.0
TLS2_k127_593780_2 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 385.0
TLS2_k127_593780_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 342.0
TLS2_k127_593780_4 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000001318 110.0
TLS2_k127_5961699_0 RNA polymerase I subunit A N-terminus K03046 - 2.7.7.6 0.0 2023.0
TLS2_k127_5961699_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1905.0
TLS2_k127_5961699_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 7.543e-305 949.0
TLS2_k127_5961699_3 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000002222 230.0
TLS2_k127_5961699_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000005085 231.0
TLS2_k127_5961699_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000002068 152.0
TLS2_k127_5961699_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000009576 83.0
TLS2_k127_5988043_0 pyruvate dehydrogenase (acetyl-transferring) activity K00163 - 1.2.4.1 0.0 1183.0
TLS2_k127_5988043_1 MMPL family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 378.0
TLS2_k127_5988043_2 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 317.0
TLS2_k127_5988043_3 Zinc-uptake complex component A periplasmic K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004216 274.0
TLS2_k127_5988043_4 Tfp pilus assembly protein FimV - - - 0.0000000000000000000000000000000000000000000000000000000004606 219.0
TLS2_k127_5988043_5 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000001562 153.0
TLS2_k127_5988043_6 PFAM ABC transporter K09817 - - 0.00000000000000000000000000000000001113 145.0
TLS2_k127_5988043_7 Biliverdin reductase A K00214 GO:0000166,GO:0003674,GO:0003824,GO:0004074,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006787,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0019439,GO:0033013,GO:0033015,GO:0034641,GO:0036094,GO:0042167,GO:0042168,GO:0042440,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046149,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575 1.3.1.24 0.00000000000000000000005506 112.0
TLS2_k127_5988043_8 DoxX K15977 - - 0.00000000000000000009725 94.0
TLS2_k127_6065238_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 465.0
TLS2_k127_6065238_1 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 323.0
TLS2_k127_6065238_2 Crossover junction endodeoxyribonuclease RuvC K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000000000000000000000000000000000000000000001035 184.0
TLS2_k127_6065238_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.000000000000000000000000000000000000000002223 162.0
TLS2_k127_6065238_4 RDD family - - - 0.000000009026 68.0
TLS2_k127_6065238_5 membrane protein domain - - - 0.0000001108 64.0
TLS2_k127_6065238_6 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000007137 57.0
TLS2_k127_607161_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 1.609e-238 753.0
TLS2_k127_607161_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 355.0
TLS2_k127_607161_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002661 281.0
TLS2_k127_607161_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000002253 109.0
TLS2_k127_607161_4 L,D-transpeptidase catalytic domain - - - 0.00000000000000000182 96.0
TLS2_k127_607161_5 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.00000000000000002172 89.0
TLS2_k127_607161_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000001505 67.0
TLS2_k127_6155064_0 magnesium ion homeostasis - - - 0.0000000000003462 72.0
TLS2_k127_6183192_0 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008251 512.0
TLS2_k127_6183192_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 461.0
TLS2_k127_6183192_10 Protein of unknown function - - - 0.00005455 56.0
TLS2_k127_6183192_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 392.0
TLS2_k127_6183192_3 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 352.0
TLS2_k127_6183192_4 SecD/SecF GG Motif K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000244 228.0
TLS2_k127_6183192_5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000000004437 194.0
TLS2_k127_6183192_6 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000001033 196.0
TLS2_k127_6183192_7 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.000000000000000000000002571 108.0
TLS2_k127_6183192_8 Family of unknown function (DUF5339) - - - 0.000000000000000004259 89.0
TLS2_k127_6183192_9 Inositol monophosphatase family K01082 - 3.1.3.7 0.0000000002832 64.0
TLS2_k127_6197315_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000007905 264.0
TLS2_k127_6197315_1 Urate oxidase N-terminal - - - 0.000000000000000006414 87.0
TLS2_k127_6208311_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005543 383.0
TLS2_k127_6208311_1 PFAM Binding-protein-dependent transport K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 338.0
TLS2_k127_6208311_10 Sirohaem biosynthesis protein central K02304 - 1.3.1.76,4.99.1.4 0.000000000007592 76.0
TLS2_k127_6208311_11 Amidohydrolase family - - - 0.0009976 49.0
TLS2_k127_6208311_2 Pfam:Methyltransf_26 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003055 309.0
TLS2_k127_6208311_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000285 177.0
TLS2_k127_6208311_4 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000001557 173.0
TLS2_k127_6208311_5 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K01838 - 5.4.2.6 0.000000000000000000000000000000000000000007284 164.0
TLS2_k127_6208311_6 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000003084 156.0
TLS2_k127_6208311_7 RNase_H superfamily K06877 - - 0.00000000000000000000000000000000000003892 150.0
TLS2_k127_6208311_8 TIGRFAM acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.0000000000000000000002313 113.0
TLS2_k127_6208311_9 Ferredoxin - - - 0.000000000000000004259 89.0
TLS2_k127_629866_0 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 318.0
TLS2_k127_629866_1 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001248 245.0
TLS2_k127_629866_2 Protein of unknown function (DUF3494) K11904 - - 0.0000000000000000000000000000000000000000000000000000000000000001078 246.0
TLS2_k127_629866_3 regulation of canonical Wnt signaling pathway involved in osteoblast differentiation - - - 0.00000000000000000000000000000000000000000000000000000001969 221.0
TLS2_k127_629866_4 PFAM thioesterase superfamily K18014 - 4.3.1.14 0.000000000000000000000000000000000000000001786 160.0
TLS2_k127_629866_5 Sulfatase-modifying factor enzyme 1 - - - 0.0001123 48.0
TLS2_k127_6302461_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1033.0
TLS2_k127_6302461_1 ABC transporter - - - 7.108e-259 808.0
TLS2_k127_6302461_10 Cytochrome C oxidase, cbb3-type, subunit III K02305 - - 0.0000000000000000008779 90.0
TLS2_k127_6302461_11 Radical SAM - - - 0.00000000000003073 81.0
TLS2_k127_6302461_12 Bacterial protein of unknown function (DUF883) - - - 0.00000009385 57.0
TLS2_k127_6302461_2 ATP-dependent helicase HrpB K03579 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 622.0
TLS2_k127_6302461_3 glutamate--cysteine ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 451.0
TLS2_k127_6302461_4 PFAM Succinylglutamate desuccinylase Aspartoacylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 406.0
TLS2_k127_6302461_5 VWA containing CoxE family protein K09989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 416.0
TLS2_k127_6302461_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 401.0
TLS2_k127_6302461_7 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 356.0
TLS2_k127_6302461_8 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000002978 136.0
TLS2_k127_6302461_9 PFAM Uncharacterised protein family UPF0047 - - - 0.000000000000000000009735 98.0
TLS2_k127_6311824_0 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008181 453.0
TLS2_k127_6311824_1 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 400.0
TLS2_k127_6311824_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000002817 235.0
TLS2_k127_6311824_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000001226 171.0
TLS2_k127_6311824_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000004584 144.0
TLS2_k127_6311824_5 Protein of unknown function (DUF971) K03593 - - 0.00000000000000000000004846 102.0
TLS2_k127_6311824_6 mannose-ethanolamine phosphotransferase activity - - - 0.00000001123 68.0
TLS2_k127_6311824_7 Alkaline phosphatase with broad substrate specificity K01077 - 3.1.3.1 0.000005041 59.0
TLS2_k127_6405801_0 TIGRFAM autotransporter-associated beta strand repeat protein - - - 0.00000000000000000000000000000000000000000000000001837 199.0
TLS2_k127_6405801_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06991 - - 0.000000000000000000000000000000000000000000009277 166.0
TLS2_k127_6405801_2 transposase activity - - - 0.000000000000000000000000004236 116.0
TLS2_k127_6405801_3 COG0625 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000003765 85.0
TLS2_k127_6501379_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005173 326.0
TLS2_k127_6501379_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008337 301.0
TLS2_k127_6501379_2 fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005746 272.0
TLS2_k127_6501379_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000003799 61.0
TLS2_k127_6591626_0 Aconitase family (aconitate hydratase) K01703 - 4.2.1.33,4.2.1.35 1.768e-218 685.0
TLS2_k127_6591626_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 461.0
TLS2_k127_6591626_2 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000005972 240.0
TLS2_k127_6591626_3 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000007941 196.0
TLS2_k127_6591626_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000002177 162.0
TLS2_k127_6591626_5 - - - - 0.00000000000000000000002943 104.0
TLS2_k127_6591626_6 acetoin utilization protein K04768 - - 0.0000000000000000002669 90.0
TLS2_k127_6604524_0 Carboxyl transferase domain - - - 1.306e-197 633.0
TLS2_k127_6604524_1 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 498.0
TLS2_k127_6604524_2 PFAM PemK-like protein K07171 - - 0.000001651 56.0
TLS2_k127_6614763_0 PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 354.0
TLS2_k127_6614763_1 CS domain K13993 - - 0.00000000000000000000000000000000001342 143.0
TLS2_k127_6697473_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.0 1214.0
TLS2_k127_6697473_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.554e-241 766.0
TLS2_k127_6697473_10 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000009255 235.0
TLS2_k127_6697473_11 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000006217 199.0
TLS2_k127_6697473_12 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000001399 181.0
TLS2_k127_6697473_13 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000000001491 135.0
TLS2_k127_6697473_14 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000002403 121.0
TLS2_k127_6697473_15 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000009526 121.0
TLS2_k127_6697473_16 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.00000000000000000000001598 114.0
TLS2_k127_6697473_17 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000007392 95.0
TLS2_k127_6697473_18 CoA-transferase family III - - - 0.000000000000004 81.0
TLS2_k127_6697473_19 Protein of unknown function (DUF503) K09764 - - 0.000000000000006968 78.0
TLS2_k127_6697473_2 Translation-initiation factor 2 K02519 - - 1.645e-237 759.0
TLS2_k127_6697473_20 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0001189 54.0
TLS2_k127_6697473_3 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 9.607e-225 706.0
TLS2_k127_6697473_4 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 8.74e-198 627.0
TLS2_k127_6697473_5 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 571.0
TLS2_k127_6697473_6 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 461.0
TLS2_k127_6697473_7 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 368.0
TLS2_k127_6697473_8 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007537 295.0
TLS2_k127_6697473_9 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000007148 241.0
TLS2_k127_6702575_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 315.0
TLS2_k127_6702575_1 NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003982 256.0
TLS2_k127_6702575_2 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000003654 220.0
TLS2_k127_6702575_3 helix_turn_helix, mercury resistance K22491 - - 0.000000000000000000000000000000000000000000000001843 186.0
TLS2_k127_6702575_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000006146 85.0
TLS2_k127_6702575_5 - - - - 0.0000000000328 64.0
TLS2_k127_6702575_6 Bacterial protein of unknown function (DUF883) - - - 0.0005712 47.0
TLS2_k127_6773961_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 4.18e-214 689.0
TLS2_k127_6773961_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.39e-202 647.0
TLS2_k127_6773961_2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 415.0
TLS2_k127_6773961_3 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 396.0
TLS2_k127_6779872_0 Glycosyl hydrolase family 65 central catalytic domain protein K00691,K05342 - 2.4.1.64,2.4.1.8 3.937e-305 957.0
TLS2_k127_6779872_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 518.0
TLS2_k127_6779872_10 Glycosyl transferase family, a/b domain K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000002758 157.0
TLS2_k127_6779872_11 YCII-related domain - - - 0.000000000000000000000000000000001814 134.0
TLS2_k127_6779872_12 oxidoreductase - - - 0.0000000000000000000000008666 112.0
TLS2_k127_6779872_13 helix_turn_helix, Lux Regulon - - - 0.0000000005978 72.0
TLS2_k127_6779872_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 424.0
TLS2_k127_6779872_3 belongs to the sigma-70 factor family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 420.0
TLS2_k127_6779872_4 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 344.0
TLS2_k127_6779872_5 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000006085 225.0
TLS2_k127_6779872_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000006788 225.0
TLS2_k127_6779872_7 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000002135 214.0
TLS2_k127_6779872_8 PFAM DGPFAETKE family protein - - - 0.0000000000000000000000000000000000000000000000000000000006665 203.0
TLS2_k127_6779872_9 Protein of unknown function (DUF1428) - - - 0.0000000000000000000000000000000000000000000000001114 181.0
TLS2_k127_6786066_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05889,K12678 - 1.1.2.6 0.0000000000000000000000000000000000000000000000008015 192.0
TLS2_k127_6790561_0 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 438.0
TLS2_k127_6790561_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000001212 190.0
TLS2_k127_6790561_2 - - - - 0.00000000000000000000000000000000000000000000000002218 198.0
TLS2_k127_6790561_3 - - - - 0.0000000000000000004702 90.0
TLS2_k127_6806238_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1030.0
TLS2_k127_6806238_1 DNA polymerase K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 615.0
TLS2_k127_6806238_10 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000001326 106.0
TLS2_k127_6806238_11 PFAM regulatory protein ArsR K03892 - - 0.0000000000000000000001482 101.0
TLS2_k127_6806238_12 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000005089 109.0
TLS2_k127_6806238_13 COG0607 Rhodanese-related sulfurtransferase - - - 0.000000000000000004752 94.0
TLS2_k127_6806238_14 - - - - 0.000000000006597 73.0
TLS2_k127_6806238_16 Lysylphosphatidylglycerol synthase TM region - - - 0.000000003999 68.0
TLS2_k127_6806238_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 602.0
TLS2_k127_6806238_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009864 580.0
TLS2_k127_6806238_4 RelA SpoT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001386 233.0
TLS2_k127_6806238_5 Quinolinate phosphoribosyl transferase, N-terminal domain K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000002215 250.0
TLS2_k127_6806238_6 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000008581 180.0
TLS2_k127_6806238_7 - - - - 0.000000000000000000000000000000001422 137.0
TLS2_k127_6806238_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.000000000000000000000000001573 114.0
TLS2_k127_6806238_9 COG2202 FOG PAS PAC domain - - - 0.0000000000000000000000002449 114.0
TLS2_k127_6815810_0 Protein tyrosine kinase - - - 0.00000000000000000000000000002315 137.0
TLS2_k127_6824090_0 PFAM ABC transporter related K15738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007066 552.0
TLS2_k127_6824090_1 to uniprot Q12382 Saccharomyces cerevisiae YOR311C HSD1 Endoplasmic reticulum (ER)-resident membrane protein overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation K16368 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576 2.7.1.174 0.00004703 54.0
TLS2_k127_6839084_0 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 443.0
TLS2_k127_6839084_1 COG0471 Di- and tricarboxylate K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 395.0
TLS2_k127_6839084_11 Fatty acid desaturase - - - 0.00000171 59.0
TLS2_k127_6839084_12 - - - - 0.0004827 43.0
TLS2_k127_6839084_2 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 363.0
TLS2_k127_6839084_3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 362.0
TLS2_k127_6839084_4 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002709 280.0
TLS2_k127_6839084_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000007641 201.0
TLS2_k127_6839084_6 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000007651 148.0
TLS2_k127_6839084_7 - - - - 0.000000000000000000004836 101.0
TLS2_k127_6839084_8 - - - - 0.0000000002075 66.0
TLS2_k127_6839084_9 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000004345 61.0
TLS2_k127_6843482_0 FAD binding domain of DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 595.0
TLS2_k127_6843482_1 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004329 579.0
TLS2_k127_6843482_2 epimerase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 542.0
TLS2_k127_6843482_3 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 436.0
TLS2_k127_6843482_4 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 437.0
TLS2_k127_6843482_5 Integral membrane protein TerC family K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 334.0
TLS2_k127_6843482_6 Rubrerythrin K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004835 278.0
TLS2_k127_6843482_7 Protein of unknown function, DUF393 - - - 0.00000000000000000000000000000000000000004978 157.0
TLS2_k127_6847846_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008367 569.0
TLS2_k127_6847846_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007302 513.0
TLS2_k127_6847846_10 MEKHLA domain - - - 0.000000000000000000000000000000000000000000425 167.0
TLS2_k127_6847846_11 COG0720 6-pyruvoyl-tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000001263 168.0
TLS2_k127_6847846_12 Iron-sulfur cluster assembly protein - - - 0.0000000000000000000000000000000002257 135.0
TLS2_k127_6847846_13 Ferredoxin, 2Fe-2S - - - 0.000000000000000000000000000000002147 131.0
TLS2_k127_6847846_14 Protein of unknown function (DUF1054) - - - 0.000000000000000000000004521 111.0
TLS2_k127_6847846_15 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000000003347 105.0
TLS2_k127_6847846_16 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000000001949 107.0
TLS2_k127_6847846_17 COG2146 Ferredoxin subunits of nitrite reductase and K00363 - 1.7.1.15 0.0000000000001878 77.0
TLS2_k127_6847846_2 TIGRFAM FeS assembly ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 397.0
TLS2_k127_6847846_3 FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 367.0
TLS2_k127_6847846_4 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005437 321.0
TLS2_k127_6847846_5 Phospholipase D. Active site motifs. K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000622 240.0
TLS2_k127_6847846_6 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000000000000000000006176 217.0
TLS2_k127_6847846_7 SUF system FeS assembly protein K04488 - - 0.00000000000000000000000000000000000000000000000000001673 197.0
TLS2_k127_6847846_8 PFAM cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000002482 184.0
TLS2_k127_6847846_9 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000285 177.0
TLS2_k127_6865813_0 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 410.0
TLS2_k127_6865813_1 Dehydrogenase E1 component K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 362.0
TLS2_k127_6865813_2 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002517 286.0
TLS2_k127_6865813_3 COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes K00627 - 2.3.1.12 0.00000000000000000000000000000001312 135.0
TLS2_k127_6865813_4 guanyl-nucleotide exchange factor activity - - - 0.00000000000000000000006616 112.0
TLS2_k127_6871309_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 2.464e-214 681.0
TLS2_k127_6871309_1 DNA topoisomerase VI subunit A K03166 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 582.0
TLS2_k127_6871309_2 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 484.0
TLS2_k127_6871309_3 Belongs to the DEAD box helicase family K05592,K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003859 447.0
TLS2_k127_6871309_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 286.0
TLS2_k127_6878573_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 316.0
TLS2_k127_6878573_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000002808 269.0
TLS2_k127_6878573_2 of the major facilitator superfamily K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002422 270.0
TLS2_k127_6878573_3 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000002074 196.0
TLS2_k127_6878573_4 Protein of unknown function (DUF420) K08976 - - 0.000000000000000000000000000000000002927 143.0
TLS2_k127_6878573_5 protein SCO1 SenC K07152 - - 0.000000000000000000000000000000000003394 154.0
TLS2_k127_6878573_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000006065 145.0
TLS2_k127_6886936_0 Fic/DOC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 462.0
TLS2_k127_6886936_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 472.0
TLS2_k127_6886936_2 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 317.0
TLS2_k127_6886936_3 - - - - 0.0000000000000000000000003441 114.0
TLS2_k127_6886936_4 tigr02147 - - - 0.000003766 56.0
TLS2_k127_689125_0 Tex-like protein N-terminal domain K06959 - - 2.039e-196 639.0
TLS2_k127_689125_1 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006317 550.0
TLS2_k127_689125_10 ATPase (AAA superfamily - - - 0.0000000000001318 72.0
TLS2_k127_689125_11 G-patch domain K13101,K13566 GO:0000375,GO:0000377,GO:0000398,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005681,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0031974,GO:0031981,GO:0032991,GO:0034641,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904 3.5.1.3 0.000000000006971 75.0
TLS2_k127_689125_12 Rhodanese Homology Domain - - - 0.00000000005674 72.0
TLS2_k127_689125_13 Protein of unknown function (DUF721) - - - 0.0000000000889 67.0
TLS2_k127_689125_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679,K01744 - 4.2.1.2,4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 510.0
TLS2_k127_689125_3 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007898 433.0
TLS2_k127_689125_4 Forkhead associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 386.0
TLS2_k127_689125_5 PFAM Methyltransferase type K15256 - - 0.00000000000000000000000000000000000000000000000000000000000000002295 230.0
TLS2_k127_689125_6 methylglyoxal synthase K01734 - 4.2.3.3 0.0000000000000000000000000000000000000000003803 162.0
TLS2_k127_689125_7 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000002184 117.0
TLS2_k127_689125_8 Belongs to the UPF0102 family K07460 - - 0.0000000000000000001321 94.0
TLS2_k127_689125_9 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000003323 97.0
TLS2_k127_6910431_0 3-keto-5-aminohexanoate cleavage protein K18013 - 2.3.1.247 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 334.0
TLS2_k127_6910431_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 317.0
TLS2_k127_6910431_2 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000009547 260.0
TLS2_k127_6910431_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000002692 222.0
TLS2_k127_6910431_4 Cellulose biosynthesis protein BcsQ K03496 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000003597 184.0
TLS2_k127_6910431_5 Periplasmic binding protein K07121 - - 0.0000000000000000000000000000000000000000001507 179.0
TLS2_k127_6910431_6 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000006425 148.0
TLS2_k127_6910431_7 Domain of unknown function (DUF4347) - - - 0.00001292 57.0
TLS2_k127_6924862_0 alcohol dehydrogenase K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 456.0
TLS2_k127_6924862_1 AAA domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004329 404.0
TLS2_k127_6924862_2 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000212 218.0
TLS2_k127_6924862_3 Protein of unknown function (DUF1579) - - - 0.000000000000000000000000000000004962 137.0
TLS2_k127_6924862_4 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.00000000000000008689 80.0
TLS2_k127_6946633_0 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 314.0
TLS2_k127_6946633_1 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000004796 230.0
TLS2_k127_6946633_2 Domain of unknown function (DUF4397) - - - 0.000000000000000003025 93.0
TLS2_k127_6946633_3 NACHT nucleoside triphosphatase - - - 0.00000000006121 68.0
TLS2_k127_695753_0 polyketide synthase - - - 5.255e-265 867.0
TLS2_k127_695753_1 Pfam:CPSase_L_chain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 478.0
TLS2_k127_695753_2 FabA-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 319.0
TLS2_k127_695753_3 Polyketide synthase modules and related proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 311.0
TLS2_k127_695753_4 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006629 263.0
TLS2_k127_695753_5 Sh3 type 3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000003928 251.0
TLS2_k127_695753_6 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000001043 244.0
TLS2_k127_695753_7 Outer membrane lipoprotein-sorting protein - - - 0.000000000000000000000000000000000000000000000000000000006609 207.0
TLS2_k127_695753_8 Biotin-requiring enzyme - - - 0.000000000000000001306 92.0
TLS2_k127_696835_0 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000001055 251.0
TLS2_k127_696835_1 peptide-methionine (S)-S-oxide reductase activity K07304,K07305,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000106 239.0
TLS2_k127_696835_2 COG3209 Rhs family protein - - - 0.00000005566 63.0
TLS2_k127_6970366_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.019e-278 868.0
TLS2_k127_6970366_1 Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 467.0
TLS2_k127_6970366_2 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 346.0
TLS2_k127_6970366_3 PFAM peptidase M16 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004099 289.0
TLS2_k127_6970366_4 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000002396 198.0
TLS2_k127_6970366_5 Ribbon-helix-helix domain - - - 0.00000000000000000003809 92.0
TLS2_k127_6974975_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 494.0
TLS2_k127_6974975_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 450.0
TLS2_k127_6974975_10 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000005005 146.0
TLS2_k127_6974975_11 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000214 125.0
TLS2_k127_6974975_12 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.000000000000000000000000008795 112.0
TLS2_k127_6974975_13 Protein of unknown function (DUF2752) - - - 0.00000000000000000001161 96.0
TLS2_k127_6974975_14 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000004927 93.0
TLS2_k127_6974975_15 - K07039 - - 0.000000000000000006278 91.0
TLS2_k127_6974975_16 Domain of unknown function (DUF4190) - - - 0.000000000000001126 86.0
TLS2_k127_6974975_17 - - - - 0.0000003982 61.0
TLS2_k127_6974975_2 Metallopeptidase family M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 372.0
TLS2_k127_6974975_3 Domain of unknown function (DUF4143) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 362.0
TLS2_k127_6974975_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 355.0
TLS2_k127_6974975_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 341.0
TLS2_k127_6974975_6 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000004678 273.0
TLS2_k127_6974975_7 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000007439 185.0
TLS2_k127_6974975_8 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000007078 169.0
TLS2_k127_6974975_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000004332 153.0
TLS2_k127_6976991_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0 1728.0
TLS2_k127_6976991_1 Psort location Cytoplasmic, score - - - 8.729e-203 644.0
TLS2_k127_6976991_2 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001243 289.0
TLS2_k127_6976991_3 lipoprotein localization to outer membrane K02004 - - 0.000000000000000000006487 104.0
TLS2_k127_6984365_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1047.0
TLS2_k127_6984365_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 541.0
TLS2_k127_6984365_10 Ribosomal protein S11 K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000006665 198.0
TLS2_k127_6984365_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000227 210.0
TLS2_k127_6984365_12 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000009755 174.0
TLS2_k127_6984365_13 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000007344 156.0
TLS2_k127_6984365_14 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000001791 157.0
TLS2_k127_6984365_15 Histidine kinase - - - 0.0000000000000000000000000000000000000005853 173.0
TLS2_k127_6984365_16 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000001024 153.0
TLS2_k127_6984365_17 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000002451 147.0
TLS2_k127_6984365_18 serine-type endopeptidase activity - - - 0.00000000000000000000000000000000000004365 150.0
TLS2_k127_6984365_19 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000006962 143.0
TLS2_k127_6984365_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 440.0
TLS2_k127_6984365_20 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000000000000000003511 128.0
TLS2_k127_6984365_21 Glutathione peroxidase - - - 0.0000000000000000000000000000000255 132.0
TLS2_k127_6984365_22 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000004401 112.0
TLS2_k127_6984365_23 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000000431 72.0
TLS2_k127_6984365_25 prohibitin homologues - - - 0.00002703 46.0
TLS2_k127_6984365_3 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 385.0
TLS2_k127_6984365_4 translation release factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 372.0
TLS2_k127_6984365_5 Methionine aminopeptidase K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 308.0
TLS2_k127_6984365_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 303.0
TLS2_k127_6984365_7 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 319.0
TLS2_k127_6984365_8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000669 284.0
TLS2_k127_6984365_9 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000621 293.0
TLS2_k127_70217_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 389.0
TLS2_k127_70217_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000853 193.0
TLS2_k127_70217_2 4Fe-4S single cluster domain of Ferredoxin I - - - 0.0000000000000000000000000000001616 124.0
TLS2_k127_70217_3 4Fe-4S double cluster binding domain K18979 - 1.17.99.6 0.000000000000000002097 89.0
TLS2_k127_70217_4 cytochrome complex assembly K02200,K04018,K19225,K20543,K21007 - 3.4.21.105 0.000000000005022 76.0
TLS2_k127_7067788_0 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 615.0
TLS2_k127_7067788_1 PFAM glycosyl transferase family 51 K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 372.0
TLS2_k127_7067788_10 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.00000000000000000000000000001546 126.0
TLS2_k127_7067788_11 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000001401 111.0
TLS2_k127_7067788_12 protein heterodimerization activity - - - 0.0000000000001414 73.0
TLS2_k127_7067788_13 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 - - 0.0000000003967 63.0
TLS2_k127_7067788_2 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 328.0
TLS2_k127_7067788_3 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 311.0
TLS2_k127_7067788_4 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000006666 225.0
TLS2_k127_7067788_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000001098 207.0
TLS2_k127_7067788_6 lipoyl(octanoyl) transferase activity K03644,K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181,2.8.1.8 0.00000000000000000000000000000000000000000000003348 177.0
TLS2_k127_7067788_7 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000009684 175.0
TLS2_k127_7067788_8 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.000000000000000000000000000000000000000001346 169.0
TLS2_k127_7067788_9 TPM domain - - - 0.0000000000000000000000000000001325 130.0
TLS2_k127_7071747_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.593e-238 749.0
TLS2_k127_7071747_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007291 479.0
TLS2_k127_7071747_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 383.0
TLS2_k127_7071747_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000001883 190.0
TLS2_k127_7071747_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000007446 151.0
TLS2_k127_7071747_5 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000003827 59.0
TLS2_k127_7081787_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 440.0
TLS2_k127_7081787_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009386 288.0
TLS2_k127_7081787_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000003752 209.0
TLS2_k127_7081787_3 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000000000000000000000000000000000000005284 190.0
TLS2_k127_7081787_4 Pfam Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000003246 123.0
TLS2_k127_7081787_5 response regulator - - - 0.00000000001597 76.0
TLS2_k127_7091914_0 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002884 290.0
TLS2_k127_7091914_1 Belongs to the peptidase M16 family K07263 - - 0.000000000000008905 76.0
TLS2_k127_7106356_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008258 591.0
TLS2_k127_7106356_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 364.0
TLS2_k127_7106356_10 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000002274 156.0
TLS2_k127_7106356_11 Reverse transcriptase-like K03469 - 3.1.26.4 0.00000000000000000000000000000000000005738 151.0
TLS2_k127_7106356_12 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000005835 142.0
TLS2_k127_7106356_13 Yqey-like protein K09117 - - 0.000000000000000000000000000000000002696 142.0
TLS2_k127_7106356_14 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000001129 93.0
TLS2_k127_7106356_15 C4-type zinc ribbon domain K07164 - - 0.00000000000000000001181 100.0
TLS2_k127_7106356_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 333.0
TLS2_k127_7106356_3 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012,K16180 - 2.8.1.6,5.4.99.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 319.0
TLS2_k127_7106356_4 zinc finger K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 317.0
TLS2_k127_7106356_5 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000005445 248.0
TLS2_k127_7106356_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003724 243.0
TLS2_k127_7106356_7 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000009992 221.0
TLS2_k127_7106356_8 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000006077 192.0
TLS2_k127_7106356_9 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000000000000000000000000000402 170.0
TLS2_k127_7154537_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1292.0
TLS2_k127_7154537_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 311.0
TLS2_k127_7154537_2 guanyl-nucleotide exchange factor activity K01179,K03929,K09612,K12287,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 0.000006713 57.0
TLS2_k127_7158042_0 ATP-dependent Clp protease, ATP-binding subunit ClpA K03694 - - 5.378e-304 956.0
TLS2_k127_7158042_1 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000001163 227.0
TLS2_k127_7158042_2 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000004338 179.0
TLS2_k127_7158042_3 HicB family - - - 0.000000000000000000000000000000002035 133.0
TLS2_k127_7158042_4 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000002465 131.0
TLS2_k127_7158042_5 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K19746 - 1.4.99.6 0.0000000000000000000000004312 115.0
TLS2_k127_7158042_6 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000906 76.0
TLS2_k127_7262578_0 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 9.776e-263 821.0
TLS2_k127_7262578_1 PGAP1-like protein - - - 0.000000000000000000000000002514 117.0
TLS2_k127_7262578_2 Rrf2 family - - - 0.0000000000000000000477 95.0
TLS2_k127_7262578_3 domain, Protein - - - 0.0000000000000000005667 102.0
TLS2_k127_7262578_4 Thioesterase superfamily - - - 0.0000000000002052 77.0
TLS2_k127_7262578_5 Pregnancy-associated plasma protein-A - - - 0.00000001111 68.0
TLS2_k127_7277111_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009117 495.0
TLS2_k127_7277111_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009983 293.0
TLS2_k127_7277111_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002365 278.0
TLS2_k127_7277111_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000000000000000001341 159.0
TLS2_k127_7278209_0 PFAM glycosyl transferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 1.544e-244 776.0
TLS2_k127_7278209_1 COG3387 Glucoamylase and related glycosyl K01178 - 3.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 544.0
TLS2_k127_7278209_2 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 332.0
TLS2_k127_7278209_3 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000001938 235.0
TLS2_k127_7278209_4 endonuclease III K07457 - - 0.00000000000000000000000000000000000000388 154.0
TLS2_k127_7278209_5 iron-sulfur cluster assembly K07400,K13628 - - 0.000000000000000000000001589 111.0
TLS2_k127_7278209_6 Belongs to the peptidase M16 family K07263 - - 0.000000000000000002344 87.0
TLS2_k127_7278209_7 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000002665 57.0
TLS2_k127_7280603_0 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000001808 108.0
TLS2_k127_7280603_1 cyclic nucleotide-gated ion channel activity K21867 - - 0.0000000000000001309 95.0
TLS2_k127_7291997_0 aminoacyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003245 419.0
TLS2_k127_7291997_1 Domain of unknown function (DUF4382) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001762 268.0
TLS2_k127_7291997_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000673 233.0
TLS2_k127_7291997_3 Belongs to the pseudouridine synthase RsuA family K06178,K06182 - 5.4.99.21,5.4.99.22 0.0000000000000000000000000000000000000000000000000003065 199.0
TLS2_k127_7291997_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000004786 181.0
TLS2_k127_7291997_5 Tetratricopeptide repeat - - - 0.000255 56.0
TLS2_k127_7322462_0 Circularly permuted ATP-grasp type 2 - - - 7.327e-244 760.0
TLS2_k127_7322462_1 succinylglutamate desuccinylase K06987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 455.0
TLS2_k127_7322462_11 Acetyltransferase (GNAT) domain - - - 0.00000000003497 68.0
TLS2_k127_7322462_12 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000002526 55.0
TLS2_k127_7322462_13 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000001773 55.0
TLS2_k127_7322462_2 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 323.0
TLS2_k127_7322462_3 Desuccinylase aspartoacylase K06987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 321.0
TLS2_k127_7322462_4 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000001036 252.0
TLS2_k127_7322462_5 Bacterial transglutaminase-like N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000004013 245.0
TLS2_k127_7322462_6 chlorophyll binding - - - 0.000000000000000000000000000000000000000000000000000008192 203.0
TLS2_k127_7322462_7 Pyridoxamine 5'-phosphate oxidase like - - - 0.00000000000000000000000000000000000000000000000008394 182.0
TLS2_k127_7322462_8 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000002495 144.0
TLS2_k127_7322462_9 G-D-S-L family lipolytic protein - - - 0.000000000000007237 87.0
TLS2_k127_7328013_0 7TM-HD extracellular K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 461.0
TLS2_k127_7328013_1 translation release factor activity K02836 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 380.0
TLS2_k127_7328013_10 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K00887,K00901 - 2.7.1.107,2.7.1.66 0.0000000000000002662 86.0
TLS2_k127_7328013_11 Metallo-peptidase family M12B Reprolysin-like - - - 0.000000009692 64.0
TLS2_k127_7328013_2 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 370.0
TLS2_k127_7328013_3 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007295 313.0
TLS2_k127_7328013_4 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 299.0
TLS2_k127_7328013_5 NAD dependent epimerase/dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001974 270.0
TLS2_k127_7328013_6 Lytic transglycosylase - - - 0.000000000000000000000000000000000000000003913 164.0
TLS2_k127_7328013_7 Uncharacterised protein family UPF0047 - - - 0.00000000000000000009967 95.0
TLS2_k127_7328013_8 GTP binding K03977 GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000002198 85.0
TLS2_k127_7328013_9 Cell surface protein - - - 0.000000000000000002764 99.0
TLS2_k127_7329504_0 CoA-binding K09181 - - 0.0 1028.0
TLS2_k127_7329504_1 protein synonym multiple resistance and pH homeostasis protein A K05565 - - 5.816e-233 743.0
TLS2_k127_7329504_10 Belongs to the universal stress protein A family - - - 0.00000000000000007595 91.0
TLS2_k127_7329504_11 Multiple resistance and pH regulation protein F K05570 - - 0.0000000000000000876 83.0
TLS2_k127_7329504_12 Glutamine amidotransferase class-I - - - 0.0000000000000005292 87.0
TLS2_k127_7329504_2 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005838 526.0
TLS2_k127_7329504_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 368.0
TLS2_k127_7329504_4 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000003217 223.0
TLS2_k127_7329504_5 Pfam:PNPOx_C K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000004309 211.0
TLS2_k127_7329504_6 Na+/H+ ion antiporter subunit K05569 - - 0.00000000000000000000000000000000000000000002328 166.0
TLS2_k127_7329504_7 Na H antiporter, MnhB K05566 - - 0.0000000000000000000000000000000003495 143.0
TLS2_k127_7329504_8 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05560,K05567 - - 0.000000000000000000000000000000005825 130.0
TLS2_k127_7329504_9 Na+/H+ antiporter subunit K05571 - - 0.000000000000000000000000001066 116.0
TLS2_k127_7331637_0 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 287.0
TLS2_k127_7331637_1 A G-specific K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002145 269.0
TLS2_k127_7331637_2 PFAM Squalene phytoene synthase K02291,K21678,K21679 - 2.5.1.103,2.5.1.32,2.5.1.99,4.2.3.156 0.0000000000000000000000000000000000000000000000000000000000000000000000000005453 270.0
TLS2_k127_7331637_3 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000001922 226.0
TLS2_k127_7331637_4 GMP synthase (glutamine-hydrolyzing) activity K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000002299 184.0
TLS2_k127_7331637_5 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.00000000000000000000000000000000000000001758 166.0
TLS2_k127_7331637_6 Flavin reductase like domain - - - 0.0000000000000000000000000000000006346 137.0
TLS2_k127_7331637_7 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000003262 135.0
TLS2_k127_7331637_8 Flavin containing amine oxidoreductase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000005028 105.0
TLS2_k127_7356213_0 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001546 268.0
TLS2_k127_7356213_1 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000001896 207.0
TLS2_k127_7356213_2 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000001802 211.0
TLS2_k127_7356213_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000004732 172.0
TLS2_k127_7356213_4 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000002584 134.0
TLS2_k127_7356213_5 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000002231 124.0
TLS2_k127_7356213_6 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000002083 105.0
TLS2_k127_742498_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1243.0
TLS2_k127_742498_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000001124 231.0
TLS2_k127_742498_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000434 184.0
TLS2_k127_742498_3 protein involved in response to NO K07234 - - 0.00000000000000000000000000000000003673 149.0
TLS2_k127_742498_4 histidine kinase A domain protein - - - 0.000000000000000000299 100.0
TLS2_k127_742498_5 MlaC protein K07323 - - 0.0002231 46.0
TLS2_k127_742498_6 protein related to plant photosystem II stability assembly factor - - - 0.0009976 49.0
TLS2_k127_7426769_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 569.0
TLS2_k127_7426769_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 558.0
TLS2_k127_7426769_10 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - 0.0002535 50.0
TLS2_k127_7426769_2 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 548.0
TLS2_k127_7426769_3 ABC-type phosphate phosphonate transport system periplasmic component K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 451.0
TLS2_k127_7426769_4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 450.0
TLS2_k127_7426769_5 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 383.0
TLS2_k127_7426769_6 TIGRFAM phosphonate ABC transporter, inner membrane subunit K02042 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 364.0
TLS2_k127_7426769_7 Binding-protein-dependent transport system inner membrane component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 328.0
TLS2_k127_7426769_8 TIGRFAM metallophosphoesterase, MG_246 BB_0505 family K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 300.0
TLS2_k127_7426769_9 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000002252 117.0
TLS2_k127_7448811_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003311 266.0
TLS2_k127_7448811_1 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000002206 113.0
TLS2_k127_7448811_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000003992 76.0
TLS2_k127_763908_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 7.776e-221 696.0
TLS2_k127_763908_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 3.269e-194 628.0
TLS2_k127_763908_10 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004233 257.0
TLS2_k127_763908_11 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000001097 231.0
TLS2_k127_763908_12 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000003513 220.0
TLS2_k127_763908_13 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds K01666 - 4.1.3.39 0.000000000000000000000000000000000000000000000008537 185.0
TLS2_k127_763908_14 OmpA family - - - 0.000000000000000000000000000000000000000000496 174.0
TLS2_k127_763908_15 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000001441 144.0
TLS2_k127_763908_16 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000001112 132.0
TLS2_k127_763908_17 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds K01666 - 4.1.3.39 0.00000000000000000002361 106.0
TLS2_k127_763908_18 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.000000000000000000146 104.0
TLS2_k127_763908_19 - - - - 0.0000000000000000005062 92.0
TLS2_k127_763908_2 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 569.0
TLS2_k127_763908_20 - - - - 0.00005899 51.0
TLS2_k127_763908_3 Aminotransferase class I and II K10206,K14261 GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 556.0
TLS2_k127_763908_4 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 574.0
TLS2_k127_763908_5 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 467.0
TLS2_k127_763908_6 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 446.0
TLS2_k127_763908_7 PFAM Homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 438.0
TLS2_k127_763908_8 LAO AO transport system ATPase K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 288.0
TLS2_k127_763908_9 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003077 272.0
TLS2_k127_765657_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000151 121.0
TLS2_k127_794043_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07712,K07714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 441.0
TLS2_k127_794043_1 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000001137 238.0
TLS2_k127_794043_2 ZIP Zinc transporter K07238,K11021,K16267 - - 0.000000000000000000000000000000000000000000000000004438 205.0
TLS2_k127_794043_3 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000436 156.0
TLS2_k127_794043_4 Phosphomethylpyrimidine kinase K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000001162 119.0
TLS2_k127_794043_5 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.000000000000000000005831 106.0
TLS2_k127_794043_6 Amino-transferase class IV K00826,K02619 - 2.6.1.42,4.1.3.38 0.0000000000000316 75.0
TLS2_k127_794043_7 Radical SAM domain protein - - - 0.00000000001972 66.0
TLS2_k127_800155_0 O-acyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003664 249.0
TLS2_k127_800155_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002197 253.0
TLS2_k127_800155_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.000000000000000000000000000000000000000000000000000000000000000008196 246.0
TLS2_k127_800155_3 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.0000000000000000000000000000000000000000000000000000000004093 206.0
TLS2_k127_800155_4 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000003911 194.0
TLS2_k127_800155_5 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000001382 168.0
TLS2_k127_800155_6 MlaC protein K07323 - - 0.000000000000000000006887 102.0
TLS2_k127_829608_0 Methionine synthase K00548 - 2.1.1.13 0.0 1342.0
TLS2_k127_829608_1 converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - 2.454e-244 767.0
TLS2_k127_829608_2 Belongs to the serpin family K13963 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 355.0
TLS2_k127_829608_3 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001286 276.0
TLS2_k127_829608_4 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000001921 182.0
TLS2_k127_829608_5 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000001097 155.0
TLS2_k127_829608_6 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.0000000000000000000000000000248 128.0
TLS2_k127_853557_0 2-Nitropropane dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 598.0
TLS2_k127_853557_1 Acyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 388.0
TLS2_k127_854055_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.071e-247 769.0
TLS2_k127_854055_1 ATP synthase alpha/beta chain, C terminal domain K02111 - 3.6.3.14 3.365e-243 759.0
TLS2_k127_854055_2 plasmid maintenance K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 297.0
TLS2_k127_854055_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001156 252.0
TLS2_k127_854055_4 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002081 251.0
TLS2_k127_854055_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000001674 119.0
TLS2_k127_854055_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000007885 113.0
TLS2_k127_854055_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000005586 92.0
TLS2_k127_854055_8 ATP synthase B/B' CF(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000007645 93.0
TLS2_k127_854055_9 ATP synthase B/B' CF(0) K02109 - - 0.0001254 50.0
TLS2_k127_868787_0 DoxX-like family - - - 0.00000000000000000000000000001129 122.0
TLS2_k127_868787_1 Platelet-activating factor acetylhydrolase, isoform II - - - 0.00000000004644 75.0
TLS2_k127_868787_2 Fatty acid desaturase - - - 0.0000005352 53.0
TLS2_k127_868787_3 ORF located using Blastx COG2801 - - - 0.00008419 48.0
TLS2_k127_868787_4 amine dehydrogenase activity - - - 0.00009728 45.0
TLS2_k127_935571_0 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1078.0
TLS2_k127_935571_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 568.0
TLS2_k127_935571_10 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000001876 190.0
TLS2_k127_935571_11 MafB19-like deaminase - - - 0.000000000000000000000000000000000000000000001571 172.0
TLS2_k127_935571_12 ApaG domain K06195 - - 0.00000000000000000000000000000000000000000002597 165.0
TLS2_k127_935571_13 OsmC-like protein - - - 0.00000000000000000000000000000000000000000299 166.0
TLS2_k127_935571_14 phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000009395 170.0
TLS2_k127_935571_15 DNA mismatch repair protein MutT K01515 - 3.6.1.13 0.0000000000000000000000000000000000000002271 156.0
TLS2_k127_935571_16 DUF218 domain - - - 0.00000000000000000000000000000000002056 143.0
TLS2_k127_935571_17 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000002571 138.0
TLS2_k127_935571_18 RF-1 domain - - - 0.0000000000000000000000000000401 121.0
TLS2_k127_935571_19 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000001477 99.0
TLS2_k127_935571_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 503.0
TLS2_k127_935571_3 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006088 317.0
TLS2_k127_935571_4 Peptidase C26 K01658,K01664 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 303.0
TLS2_k127_935571_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 287.0
TLS2_k127_935571_6 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001258 277.0
TLS2_k127_935571_7 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007804 261.0
TLS2_k127_935571_8 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000002326 259.0
TLS2_k127_935571_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000001026 182.0
TLS2_k127_999881_0 Ferrous iron transport protein B K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 515.0
TLS2_k127_999881_1 Peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 488.0
TLS2_k127_999881_10 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.000000000000000000000000000001612 129.0
TLS2_k127_999881_11 histidine kinase - - - 0.000000000000000001235 94.0
TLS2_k127_999881_12 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000003223 91.0
TLS2_k127_999881_13 Helix-turn-helix domain - - - 0.00000000000008382 76.0
TLS2_k127_999881_14 FeoA K04758 - - 0.000000000003615 70.0
TLS2_k127_999881_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 378.0
TLS2_k127_999881_3 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 294.0
TLS2_k127_999881_4 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004214 293.0
TLS2_k127_999881_5 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006224 269.0
TLS2_k127_999881_6 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000789 250.0
TLS2_k127_999881_7 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000004473 161.0
TLS2_k127_999881_8 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14 0.00000000000000000000000000000000000000001105 156.0
TLS2_k127_999881_9 Peptidase family M48 - - - 0.00000000000000000000000000000002697 136.0