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Overview

ID MAG04032
Name TLS2_bin.9
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Woeseiales
Family Woeseiaceae
Genus IDS-8
Species
Assembly information
Completeness (%) 96.04
Contamination (%) 2.07
GC content (%) 62.0
N50 (bp) 23,750
Genome size (bp) 4,087,436

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3518

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1010079_0 His Kinase A (phosphoacceptor) domain - - - 1.592e-232 730.0
TLS2_k127_1010079_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 506.0
TLS2_k127_1010079_10 transcriptional regulator, XRE family - - - 0.00000000000000000005144 93.0
TLS2_k127_1010079_11 Fic/DOC family - - - 0.00000000000002088 75.0
TLS2_k127_1010079_12 Domain of unknown function (DUF5122) beta-propeller - - - 0.000123 48.0
TLS2_k127_1010079_2 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007475 431.0
TLS2_k127_1010079_3 Pfam:HipA_N K07154 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 432.0
TLS2_k127_1010079_4 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 299.0
TLS2_k127_1010079_5 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 295.0
TLS2_k127_1010079_6 GntR family transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002563 258.0
TLS2_k127_1010079_7 Outer membrane protein beta-barrel family - - - 0.0000000000000000000000000000000000000000000000000000001311 199.0
TLS2_k127_1010079_8 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000003114 194.0
TLS2_k127_1010079_9 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000005483 181.0
TLS2_k127_1031625_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 502.0
TLS2_k127_1031625_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009148 252.0
TLS2_k127_1031625_2 Protein of unknown function (DUF2914) - - - 0.000000000000000000000009633 113.0
TLS2_k127_1031625_3 RQC domain - - - 0.000000000005319 68.0
TLS2_k127_1031625_4 Probable zinc-ribbon domain - - - 0.000000005574 58.0
TLS2_k127_1031625_5 RQC domain - - - 0.0008835 45.0
TLS2_k127_1033233_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1046.0
TLS2_k127_1033233_1 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004981 593.0
TLS2_k127_1033233_10 TIGRFAM Cytochrome c-type biogenesis protein CcmI K02200 - - 0.0000000000000000000000000000000000000003957 162.0
TLS2_k127_1033233_11 TIGRFAM periplasmic protein K02199 - - 0.000000000000000000000000000000401 124.0
TLS2_k127_1033233_12 subunit of a heme lyase K02200 - - 0.00000000000000000000000000002008 124.0
TLS2_k127_1033233_13 Protein of unknown function (DUF3108) - - - 0.0000000000000004646 88.0
TLS2_k127_1033233_14 - - - - 0.000001407 53.0
TLS2_k127_1033233_2 PFAM Pyridoxal-dependent decarboxylase conserved domain K01580,K13745 - 4.1.1.15,4.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 506.0
TLS2_k127_1033233_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 466.0
TLS2_k127_1033233_4 COG0665 Glycine D-amino acid oxidases (deaminating) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 435.0
TLS2_k127_1033233_5 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 396.0
TLS2_k127_1033233_6 cytochrome p450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 326.0
TLS2_k127_1033233_7 membrane protein, terc - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 282.0
TLS2_k127_1033233_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000003192 207.0
TLS2_k127_1033233_9 Domain of unknown function (DUF374) - - - 0.00000000000000000000000000000000000000000002006 173.0
TLS2_k127_1041540_0 sodium proton antiporter - - - 2.237e-215 677.0
TLS2_k127_1041540_1 PFAM D-aminoacylase, C-terminal region K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 565.0
TLS2_k127_1041540_2 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 452.0
TLS2_k127_1041540_3 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 427.0
TLS2_k127_1041540_4 Belongs to the arginase family K01476 - 3.5.3.1 0.0000000000000000000000000014 124.0
TLS2_k127_1041540_5 ester cyclase - - - 0.0000000000000000000002405 100.0
TLS2_k127_1049419_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 0.0 1137.0
TLS2_k127_1049419_1 Prolyl oligopeptidase, N-terminal beta-propeller domain - - - 2.328e-258 812.0
TLS2_k127_1049419_10 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 490.0
TLS2_k127_1049419_11 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 454.0
TLS2_k127_1049419_12 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 416.0
TLS2_k127_1049419_13 Belongs to the ABC transporter superfamily K02031,K02032 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 417.0
TLS2_k127_1049419_14 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 392.0
TLS2_k127_1049419_15 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 390.0
TLS2_k127_1049419_16 transporter, permease K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 357.0
TLS2_k127_1049419_17 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 340.0
TLS2_k127_1049419_18 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009464 346.0
TLS2_k127_1049419_19 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K15582 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 320.0
TLS2_k127_1049419_2 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 5.402e-254 798.0
TLS2_k127_1049419_20 abc transporter atp-binding protein K09697 - 3.6.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 305.0
TLS2_k127_1049419_21 permease K09696 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002297 282.0
TLS2_k127_1049419_22 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000001024 238.0
TLS2_k127_1049419_23 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000009681 235.0
TLS2_k127_1049419_24 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000000000002282 216.0
TLS2_k127_1049419_25 cytochrome - - - 0.00000000000000000000000000000000000000000002678 171.0
TLS2_k127_1049419_26 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000008259 100.0
TLS2_k127_1049419_27 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000002431 74.0
TLS2_k127_1049419_28 identical protein binding - GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00002267 57.0
TLS2_k127_1049419_3 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 2.069e-240 751.0
TLS2_k127_1049419_4 2-methylcitrate dehydratase K01720 - 4.2.1.79 3.39e-221 694.0
TLS2_k127_1049419_5 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 9.101e-207 663.0
TLS2_k127_1049419_6 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 9.541e-196 624.0
TLS2_k127_1049419_7 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 515.0
TLS2_k127_1049419_8 Belongs to the citrate synthase family K01659 - 2.3.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 503.0
TLS2_k127_1049419_9 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007917 503.0
TLS2_k127_1059912_0 response regulator receiver K02487,K06596 - - 0.0 1065.0
TLS2_k127_1059912_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.292e-274 860.0
TLS2_k127_1059912_10 Type IV pili methyl-accepting chemotaxis transducer N-term K02660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 427.0
TLS2_k127_1059912_11 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 415.0
TLS2_k127_1059912_12 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 390.0
TLS2_k127_1059912_13 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 385.0
TLS2_k127_1059912_14 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 389.0
TLS2_k127_1059912_15 TonB-dependent Receptor Plug K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 392.0
TLS2_k127_1059912_16 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 375.0
TLS2_k127_1059912_17 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 334.0
TLS2_k127_1059912_18 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 299.0
TLS2_k127_1059912_19 Protein of unknown function, DUF484 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 297.0
TLS2_k127_1059912_2 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 9.466e-204 639.0
TLS2_k127_1059912_20 adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000002611 256.0
TLS2_k127_1059912_21 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000004242 243.0
TLS2_k127_1059912_22 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002605 242.0
TLS2_k127_1059912_23 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000477 231.0
TLS2_k127_1059912_24 Periplasmic binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000007305 233.0
TLS2_k127_1059912_25 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000000000000000000000003256 228.0
TLS2_k127_1059912_26 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000003628 223.0
TLS2_k127_1059912_27 response regulator receiver K02657 - - 0.000000000000000000000000000000000000000000000000000000000002881 211.0
TLS2_k127_1059912_28 Required for insertion of 4Fe-4S clusters K15724 - - 0.00000000000000000000000000000000000000000000000000005283 190.0
TLS2_k127_1059912_29 response regulator receiver K02658 - - 0.000000000000000000000000000000000000000000003008 167.0
TLS2_k127_1059912_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 571.0
TLS2_k127_1059912_30 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000006529 169.0
TLS2_k127_1059912_31 Amidohydrolase family - - - 0.000000000000000000000000000000000000000009455 176.0
TLS2_k127_1059912_32 PFAM conserved K08973 - - 0.000000000000000000000000000000000000001192 151.0
TLS2_k127_1059912_33 Two component signalling adaptor domain K02659 - - 0.000000000000000000000000000000000006184 143.0
TLS2_k127_1059912_34 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000001673 138.0
TLS2_k127_1059912_35 - - - - 0.000000000000000000000000000000002315 129.0
TLS2_k127_1059912_36 Membrane protein required for beta-lactamase induction K03807 - - 0.0000000000000000000000000000002082 139.0
TLS2_k127_1059912_37 N-acetylglucosaminylinositol deacetylase activity - - - 0.000000000000000000000000003467 121.0
TLS2_k127_1059912_38 - - - - 0.00000000000000000000000001652 118.0
TLS2_k127_1059912_39 Two component signalling adaptor domain K06598 - - 0.00000000000000000004644 96.0
TLS2_k127_1059912_4 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 538.0
TLS2_k127_1059912_41 Cysteine-rich CPXCG - - - 0.000000000666 66.0
TLS2_k127_1059912_42 amidohydrolase - - - 0.0000002361 64.0
TLS2_k127_1059912_5 permease protein K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 499.0
TLS2_k127_1059912_6 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 435.0
TLS2_k127_1059912_7 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 424.0
TLS2_k127_1059912_8 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 415.0
TLS2_k127_1059912_9 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 421.0
TLS2_k127_1098025_0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 2.111e-259 814.0
TLS2_k127_1098025_1 Reduces the stability of FtsZ polymers in the presence of ATP K06916 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 358.0
TLS2_k127_1098025_2 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000011 228.0
TLS2_k127_1098025_3 MarR family transcriptional regulator - - - 0.000000000000000000000000000000000000000000003188 169.0
TLS2_k127_1107001_0 Protein involved in poly(beta-D-mannuronate) lyase activity - - - 2.149e-289 909.0
TLS2_k127_1107001_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 9.593e-211 662.0
TLS2_k127_1107001_10 Iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009757 289.0
TLS2_k127_1107001_11 Stealth protein CR2, conserved region 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001883 304.0
TLS2_k127_1107001_12 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001195 261.0
TLS2_k127_1107001_13 phosphomannomutase K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000135 251.0
TLS2_k127_1107001_14 - - - - 0.000000000000000000000000000000000000000000000000000005249 199.0
TLS2_k127_1107001_15 COG0463 Glycosyltransferases involved in cell wall biogenesis K16698 - - 0.00000000000000000000000000000000000000000000000000001481 198.0
TLS2_k127_1107001_16 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000008562 192.0
TLS2_k127_1107001_17 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000006 164.0
TLS2_k127_1107001_2 Phosphoenolpyruvate phosphomutase K01841 - 5.4.2.9 3.826e-210 663.0
TLS2_k127_1107001_20 Polysaccharide biosynthesis/export protein - - - 0.00000000000000000000000006402 109.0
TLS2_k127_1107001_21 LICD family K02011,K07271,K19872 - - 0.00000000000000000000000081 122.0
TLS2_k127_1107001_22 Tetratricopeptide repeat - - - 0.000000000001122 81.0
TLS2_k127_1107001_23 - - - - 0.000000000001454 80.0
TLS2_k127_1107001_24 Tetratricopeptide repeat - - - 0.000006954 59.0
TLS2_k127_1107001_3 Polysaccharide biosynthesis protein K17716 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 592.0
TLS2_k127_1107001_4 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 552.0
TLS2_k127_1107001_5 PFAM thiamine pyrophosphate protein domain protein TPP-binding K09459 - 4.1.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 436.0
TLS2_k127_1107001_6 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 406.0
TLS2_k127_1107001_7 Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 419.0
TLS2_k127_1107001_8 glycosyl transferase K13007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 368.0
TLS2_k127_1107001_9 epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 331.0
TLS2_k127_1112236_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.0 1420.0
TLS2_k127_1112236_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 2.041e-215 679.0
TLS2_k127_1112236_2 PFAM PhoH family protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 414.0
TLS2_k127_1112236_3 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004643 287.0
TLS2_k127_1112236_4 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000000000000000000000002521 209.0
TLS2_k127_1112236_5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000003805 156.0
TLS2_k127_1146683_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007704 481.0
TLS2_k127_1146683_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 305.0
TLS2_k127_1146683_2 AMP-dependent synthetase - - - 0.00000000103 61.0
TLS2_k127_1149697_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1146.0
TLS2_k127_1149697_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1024.0
TLS2_k127_1149697_10 NUDIX domain K08310 - 3.6.1.67 0.0000000000000000000000000002074 125.0
TLS2_k127_1149697_11 Regulatory protein, FmdB family - - - 0.000000000000000000000000292 109.0
TLS2_k127_1149697_12 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.000000000000000000000001768 103.0
TLS2_k127_1149697_13 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000004918 108.0
TLS2_k127_1149697_14 - - - - 0.0000000342 56.0
TLS2_k127_1149697_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.285e-258 809.0
TLS2_k127_1149697_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 560.0
TLS2_k127_1149697_4 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 557.0
TLS2_k127_1149697_5 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000706 317.0
TLS2_k127_1149697_6 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000000000002312 218.0
TLS2_k127_1149697_7 Belongs to the CinA family K03743 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159 3.5.1.42 0.00000000000000000000000000000000000000000512 164.0
TLS2_k127_1149697_8 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000007916 166.0
TLS2_k127_1149697_9 Modulates RecA activity K03565 - - 0.000000000000000000000000000000003391 134.0
TLS2_k127_1152351_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 3.491e-279 865.0
TLS2_k127_1152351_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.604e-231 726.0
TLS2_k127_1152351_10 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000007687 207.0
TLS2_k127_1152351_11 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000001144 192.0
TLS2_k127_1152351_12 Hemerythrin - - - 0.00000000000000000000000000000000000000000000000001813 184.0
TLS2_k127_1152351_13 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000000000193 179.0
TLS2_k127_1152351_14 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.0000000000000000000000000000000000000000000000008543 175.0
TLS2_k127_1152351_15 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.00000000000000000000000000000000000000000001249 169.0
TLS2_k127_1152351_16 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.0000000000000000000000000000000000000000004157 171.0
TLS2_k127_1152351_17 DoxX K15977 - - 0.000000000000000000000000000000000000001618 159.0
TLS2_k127_1152351_18 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000005656 126.0
TLS2_k127_1152351_19 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters K03557 - - 0.000000000000000000005776 96.0
TLS2_k127_1152351_2 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 2.391e-230 719.0
TLS2_k127_1152351_20 Protein of unknown function (DUF3426) - - - 0.00001904 58.0
TLS2_k127_1152351_21 Protein of unknown function (DUF3426) - - - 0.0002295 54.0
TLS2_k127_1152351_3 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 2.677e-208 659.0
TLS2_k127_1152351_4 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 598.0
TLS2_k127_1152351_5 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 560.0
TLS2_k127_1152351_6 Oxidoreductase molybdopterin binding domain K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 401.0
TLS2_k127_1152351_7 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000941 392.0
TLS2_k127_1152351_8 'Molybdopterin K03750 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 338.0
TLS2_k127_1152351_9 Met-10+ like-protein K02687 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001735 288.0
TLS2_k127_1229950_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 8.993e-314 975.0
TLS2_k127_1229950_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 1.096e-294 917.0
TLS2_k127_1229950_10 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008235 536.0
TLS2_k127_1229950_11 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 484.0
TLS2_k127_1229950_12 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 475.0
TLS2_k127_1229950_13 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 445.0
TLS2_k127_1229950_14 Arabinose 5-phosphate isomerase K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 423.0
TLS2_k127_1229950_15 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008499 368.0
TLS2_k127_1229950_16 ABC transporter ATP-binding protein K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 346.0
TLS2_k127_1229950_17 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005246 302.0
TLS2_k127_1229950_18 antiporter K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 293.0
TLS2_k127_1229950_19 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain K04691,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002253 259.0
TLS2_k127_1229950_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.885e-243 758.0
TLS2_k127_1229950_20 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000246 253.0
TLS2_k127_1229950_21 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000004316 259.0
TLS2_k127_1229950_22 TraB family K09973 - - 0.0000000000000000000000000000000000000000000000000000000003669 215.0
TLS2_k127_1229950_23 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.000000000000000000000000000000000000000000000000000000002293 208.0
TLS2_k127_1229950_24 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000006803 191.0
TLS2_k127_1229950_25 PFAM peptidase S16 lon domain protein K07157 - - 0.0000000000000000000000000000000000000000000000000007864 190.0
TLS2_k127_1229950_26 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 0.00000000000000000000000000000000000000001411 166.0
TLS2_k127_1229950_27 Sigma 54 modulation protein K05808 - - 0.00000000000000000000000000000000000002069 147.0
TLS2_k127_1229950_28 PTS fructose transporter subunit IIA K02806 - - 0.0000000000000000000000000000000003945 137.0
TLS2_k127_1229950_29 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000000001441 108.0
TLS2_k127_1229950_3 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 9.628e-203 639.0
TLS2_k127_1229950_30 Belongs to the BolA IbaG family - - - 0.0000000000000000000013 101.0
TLS2_k127_1229950_31 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.0000002051 59.0
TLS2_k127_1229950_32 - - - - 0.0000044 55.0
TLS2_k127_1229950_33 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.00001472 55.0
TLS2_k127_1229950_4 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.639e-194 612.0
TLS2_k127_1229950_5 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008451 578.0
TLS2_k127_1229950_6 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 572.0
TLS2_k127_1229950_7 protein conserved in bacteria K09989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 560.0
TLS2_k127_1229950_8 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 552.0
TLS2_k127_1229950_9 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 541.0
TLS2_k127_1259617_0 receptor - - - 1.035e-259 823.0
TLS2_k127_1259617_1 COG0457 FOG TPR repeat - - - 5.664e-225 716.0
TLS2_k127_1259617_2 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 470.0
TLS2_k127_1259617_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 375.0
TLS2_k127_1259617_4 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002436 286.0
TLS2_k127_1277395_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 539.0
TLS2_k127_1277395_1 Domain of unknown function (DUF4154) - - - 0.0000000000000000000001694 108.0
TLS2_k127_1277395_2 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00000000001028 74.0
TLS2_k127_1315997_0 Colicin V production protein K03558 - - 0.00000000000000000000000002432 115.0
TLS2_k127_1315997_1 Sporulation related domain K03749 - - 0.000000000004853 74.0
TLS2_k127_1315997_2 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0001643 45.0
TLS2_k127_1319985_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1157.0
TLS2_k127_1407238_0 Sulfatase - - - 1.611e-219 693.0
TLS2_k127_1407238_1 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 449.0
TLS2_k127_1407238_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 291.0
TLS2_k127_1407238_3 DsrE/DsrF-like family - - - 0.0000000000000000000000000000000000000000000000000000000000008152 213.0
TLS2_k127_1407238_4 COG3279 Response regulator of the LytR AlgR family - - - 0.00000000000000000009155 94.0
TLS2_k127_1407238_5 peptidyl-tyrosine sulfation - - - 0.0000000000000000009281 100.0
TLS2_k127_1407238_6 protein kinase activity - - - 0.00000000000003835 85.0
TLS2_k127_1444922_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - 4.883e-223 741.0
TLS2_k127_1444922_1 Drug exporters of the RND superfamily - - - 0.000000000000000000000000000000000000000000000000006736 189.0
TLS2_k127_1444922_2 PIN domain - - - 0.000000000000000000007235 97.0
TLS2_k127_1444922_3 - - - - 0.0000000000005724 75.0
TLS2_k127_1444922_4 - K07339 - - 0.0000000000007203 71.0
TLS2_k127_1444922_5 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000008616 54.0
TLS2_k127_1444922_6 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.0002532 48.0
TLS2_k127_1444922_7 transcriptional regulator K07727 - - 0.0007209 48.0
TLS2_k127_1444922_8 Coagulation factor 5/8 C-terminal domain, discoidin domain - - - 0.0008 48.0
TLS2_k127_1451191_0 PFAM response regulator receiver K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 480.0
TLS2_k127_1451191_1 Fis family transcriptional regulator K10941 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 440.0
TLS2_k127_1451191_10 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.000408 43.0
TLS2_k127_1451191_11 SpoVT / AbrB like domain - - - 0.0009014 46.0
TLS2_k127_1451191_2 The M ring may be actively involved in energy transduction K02409 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 420.0
TLS2_k127_1451191_3 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 343.0
TLS2_k127_1451191_4 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 348.0
TLS2_k127_1451191_5 Histidine kinase K10942 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002345 260.0
TLS2_k127_1451191_6 flagellar protein FliS K02422 - - 0.000000000000000000000000000005043 134.0
TLS2_k127_1451191_7 PFAM Flagellar hook-basal body complex protein FliE K02408 - - 0.00000000000000000003046 97.0
TLS2_k127_1451191_8 PIN domain - - - 0.000000000000009259 81.0
TLS2_k127_1451191_9 TIGRFAM flagellar hook-associated protein 3 K02397 - - 0.000000001158 59.0
TLS2_k127_1471172_0 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 469.0
TLS2_k127_1471172_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 375.0
TLS2_k127_1471172_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 378.0
TLS2_k127_1471172_3 Domain of unknown function (DUF4168) - - - 0.00000001153 63.0
TLS2_k127_1493192_0 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K15022 - 1.17.1.10 1.264e-282 880.0
TLS2_k127_1493192_1 Peptidase inhibitor I9 - - - 2.263e-274 878.0
TLS2_k127_1493192_10 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 429.0
TLS2_k127_1493192_11 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009175 405.0
TLS2_k127_1493192_12 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 407.0
TLS2_k127_1493192_13 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005045 376.0
TLS2_k127_1493192_14 ApbE family K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 316.0
TLS2_k127_1493192_15 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 306.0
TLS2_k127_1493192_16 beta-keto acid cleavage enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001135 254.0
TLS2_k127_1493192_17 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000001339 239.0
TLS2_k127_1493192_18 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000002355 217.0
TLS2_k127_1493192_19 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000009883 147.0
TLS2_k127_1493192_2 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 4.136e-265 827.0
TLS2_k127_1493192_20 Thioredoxin-like - - - 0.00000000000000000000000000000000000482 142.0
TLS2_k127_1493192_21 DNA-templated transcription, initiation K03088,K03091 - - 0.000000000000000000000000000000001366 138.0
TLS2_k127_1493192_22 Lipid A Biosynthesis - - - 0.00000000000000000000000000006354 126.0
TLS2_k127_1493192_23 Domain of unknown function (DUF4266) - - - 0.0000000000000000000005847 97.0
TLS2_k127_1493192_24 - - - - 0.0000000000000001362 84.0
TLS2_k127_1493192_25 - - - - 0.000000000001437 76.0
TLS2_k127_1493192_26 FecR protein K07165 - - 0.0004836 51.0
TLS2_k127_1493192_3 Nitrite reductase K15864 - 1.7.2.1,1.7.99.1 2.974e-262 838.0
TLS2_k127_1493192_4 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K12980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 531.0
TLS2_k127_1493192_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008966 474.0
TLS2_k127_1493192_6 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 466.0
TLS2_k127_1493192_7 TonB-dependent heme hemoglobin receptor K16087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 466.0
TLS2_k127_1493192_8 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 454.0
TLS2_k127_1493192_9 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 437.0
TLS2_k127_1527379_0 Domain of unknown function DUF87 - - - 3.8e-261 827.0
TLS2_k127_1527379_1 Angiotensin-converting enzyme K01283 - 3.4.15.1 3.313e-225 712.0
TLS2_k127_1527379_2 TIGRFAM amino acid peptide transporter (Peptide H symporter), bacterial K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 392.0
TLS2_k127_1527379_3 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 308.0
TLS2_k127_1527379_4 Serine protease inhibitor - - - 0.000000000000000000000000000000000000000000000000000000000000277 224.0
TLS2_k127_1527379_5 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000000000000000000000000000000002541 207.0
TLS2_k127_1542166_0 Tryptophan halogenase K14266 - 1.14.19.9 6.735e-216 685.0
TLS2_k127_1542166_1 A domain family that is part of the cupin metalloenzyme superfamily. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 512.0
TLS2_k127_1542166_2 Tryptophan halogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 462.0
TLS2_k127_1542166_3 SapC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 288.0
TLS2_k127_155369_0 peptidase M48, Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 400.0
TLS2_k127_155369_1 beta' subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 304.0
TLS2_k127_15743_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 466.0
TLS2_k127_15743_1 CoA-transferase family III K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 446.0
TLS2_k127_15743_10 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 304.0
TLS2_k127_15743_11 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 325.0
TLS2_k127_15743_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002741 289.0
TLS2_k127_15743_13 Ceramidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008748 267.0
TLS2_k127_15743_14 transport system, ATPase component K02013,K05776 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000009036 266.0
TLS2_k127_15743_15 D-arabinono-1,4-lactone oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005499 269.0
TLS2_k127_15743_16 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007053 255.0
TLS2_k127_15743_17 PFAM Surface antigen K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000002431 247.0
TLS2_k127_15743_18 Protein of unknown function (DUF819) - - - 0.0000000000000000000000000000000000000000000000000000000000000008368 233.0
TLS2_k127_15743_19 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000000000000000000000000000000000000000000000000000004568 211.0
TLS2_k127_15743_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 438.0
TLS2_k127_15743_20 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000005087 192.0
TLS2_k127_15743_21 CBS domain - - - 0.0000000000000000000000000000000000000000000000002128 181.0
TLS2_k127_15743_22 - - - - 0.000000000000000000000000000000000001352 146.0
TLS2_k127_15743_23 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000008819 138.0
TLS2_k127_15743_25 Outer membrane protein, 28 kDa K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000004761 139.0
TLS2_k127_15743_26 - - - - 0.000000000000000000000000000001195 134.0
TLS2_k127_15743_27 GIY-YIG catalytic domain K07461 - - 0.00000000000000000001472 96.0
TLS2_k127_15743_28 protein conserved in bacteria - - - 0.00000000000000000003053 99.0
TLS2_k127_15743_29 - - - - 0.000000000001436 78.0
TLS2_k127_15743_3 antibiotic catabolic process K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 413.0
TLS2_k127_15743_30 Nuclease-related domain - - - 0.000000000002371 76.0
TLS2_k127_15743_31 Beta-lactamase enzyme family - - - 0.00000000004435 67.0
TLS2_k127_15743_33 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0008313 49.0
TLS2_k127_15743_4 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 417.0
TLS2_k127_15743_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 384.0
TLS2_k127_15743_6 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 379.0
TLS2_k127_15743_7 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 364.0
TLS2_k127_15743_8 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 352.0
TLS2_k127_15743_9 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 354.0
TLS2_k127_1582357_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 2.714e-236 753.0
TLS2_k127_1582357_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 600.0
TLS2_k127_1582357_10 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000000000004033 132.0
TLS2_k127_1582357_11 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.0000000000000009529 77.0
TLS2_k127_1582357_12 membrane - - - 0.00000000000397 77.0
TLS2_k127_1582357_13 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000005922 70.0
TLS2_k127_1582357_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 326.0
TLS2_k127_1582357_3 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008137 280.0
TLS2_k127_1582357_4 Zeta toxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000001335 239.0
TLS2_k127_1582357_5 (FHA) domain - - - 0.00000000000000000000000000000000000000000000000000000000000001165 226.0
TLS2_k127_1582357_6 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000007435 216.0
TLS2_k127_1582357_7 metal-binding protein - - - 0.0000000000000000000000000000000000000000000000000000001771 202.0
TLS2_k127_1582357_8 binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000000000002095 174.0
TLS2_k127_1582357_9 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000001888 175.0
TLS2_k127_1650911_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2191.0
TLS2_k127_1650911_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000139 233.0
TLS2_k127_1650911_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000008941 225.0
TLS2_k127_1693808_0 Belongs to the Orn Lys Arg decarboxylase class-II family K00928,K12526 - 2.7.2.4,4.1.1.20 6.824e-293 923.0
TLS2_k127_1693808_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 7.835e-264 823.0
TLS2_k127_1693808_10 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013,K15509 - 1.1.1.23,1.1.1.308 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 445.0
TLS2_k127_1693808_11 histidinol-phosphatase activity K01089 - 3.1.3.15,4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 434.0
TLS2_k127_1693808_12 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 425.0
TLS2_k127_1693808_13 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 419.0
TLS2_k127_1693808_14 MotA TolQ ExbB proton channel family protein K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 421.0
TLS2_k127_1693808_15 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 372.0
TLS2_k127_1693808_16 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 356.0
TLS2_k127_1693808_17 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 324.0
TLS2_k127_1693808_18 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 320.0
TLS2_k127_1693808_19 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008466 285.0
TLS2_k127_1693808_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.089e-206 653.0
TLS2_k127_1693808_20 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001047 283.0
TLS2_k127_1693808_21 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000002084 272.0
TLS2_k127_1693808_22 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000005111 260.0
TLS2_k127_1693808_23 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000001743 237.0
TLS2_k127_1693808_24 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000777 214.0
TLS2_k127_1693808_25 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000002099 235.0
TLS2_k127_1693808_26 Protein of unknown function (DUF3450) - - - 0.000000000000000000000000000000000000000000000000000000000194 212.0
TLS2_k127_1693808_27 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000002575 208.0
TLS2_k127_1693808_28 MotA/TolQ/ExbB proton channel family K03561 - - 0.000000000000000000000000000000000000000000000000000002522 201.0
TLS2_k127_1693808_29 biopolymer transport protein K03559 - - 0.00000000000000000000000000000000000000000000000001772 182.0
TLS2_k127_1693808_3 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 586.0
TLS2_k127_1693808_30 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000000000000000000000000000000000000000000414 170.0
TLS2_k127_1693808_31 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000000000000079 150.0
TLS2_k127_1693808_32 protein, YerC YecD - - - 0.0000000000000000000000000689 112.0
TLS2_k127_1693808_33 Histidine biosynthesis bifunctional protein HisIE K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.0000000000000002456 90.0
TLS2_k127_1693808_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007542 586.0
TLS2_k127_1693808_5 cystathionine K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 514.0
TLS2_k127_1693808_6 glycolate oxidase subunit GlcD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 511.0
TLS2_k127_1693808_7 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 490.0
TLS2_k127_1693808_8 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 449.0
TLS2_k127_1693808_9 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008687 447.0
TLS2_k127_171667_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.507e-297 925.0
TLS2_k127_171667_1 Amidohydrolase family - - - 2.015e-218 691.0
TLS2_k127_171667_10 MerR HTH family regulatory protein K18997 - - 0.00000000000000000000003598 102.0
TLS2_k127_171667_11 Diguanylate cyclase - - - 0.00007439 46.0
TLS2_k127_171667_2 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 364.0
TLS2_k127_171667_3 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 361.0
TLS2_k127_171667_4 DnaJ-class molecular chaperone K05516 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 363.0
TLS2_k127_171667_5 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 306.0
TLS2_k127_171667_6 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 301.0
TLS2_k127_171667_7 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000002828 228.0
TLS2_k127_171667_8 Transglycosylase associated protein - - - 0.000000000000000000000000000001926 122.0
TLS2_k127_171667_9 Domain of unknown function (DUF4398) - - - 0.00000000000000000000000000007103 121.0
TLS2_k127_1737809_0 Tryptophan halogenase K14266 - 1.14.19.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 497.0
TLS2_k127_1737809_1 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 494.0
TLS2_k127_1737809_2 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.0000000000000000000000000000000000000000001073 168.0
TLS2_k127_1737809_3 threonine efflux protein - - - 0.0001682 46.0
TLS2_k127_174822_0 L-arabinose isomerase C-terminal domain K01804 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.3.1.4 6.508e-235 747.0
TLS2_k127_174822_1 PFAM FGGY family of carbohydrate kinases, N-terminal domain - - - 1.068e-206 655.0
TLS2_k127_174822_2 C-terminal of Glycosyl hydrolases family 43 K06113 - 3.2.1.99 3.487e-205 659.0
TLS2_k127_174822_3 Class II Aldolase and Adducin N-terminal domain K03077 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 377.0
TLS2_k127_174822_4 FCD - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004204 269.0
TLS2_k127_174822_5 HAD-hyrolase-like K01838 - 5.4.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000009326 243.0
TLS2_k127_1798365_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 444.0
TLS2_k127_1798365_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 355.0
TLS2_k127_1798365_2 Protein of unknown function (DUF1232) - - - 0.0000000000000000000000000000000003135 138.0
TLS2_k127_1798365_3 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000002595 95.0
TLS2_k127_1799710_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 4.622e-317 979.0
TLS2_k127_1799710_1 Transfers the fatty acyl group on membrane lipoproteins K03820 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 372.0
TLS2_k127_1799710_2 PFAM CBS domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001315 282.0
TLS2_k127_1892486_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 590.0
TLS2_k127_1892486_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008219 506.0
TLS2_k127_1892486_10 NifU-like N terminal domain - - - 0.0000000005308 65.0
TLS2_k127_1892486_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 420.0
TLS2_k127_1892486_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 382.0
TLS2_k127_1892486_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 331.0
TLS2_k127_1892486_5 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 326.0
TLS2_k127_1892486_6 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000000000000000000000000000000000002291 267.0
TLS2_k127_1892486_7 Belongs to the HesB IscA family K05997,K13628 - - 0.000000000000000000000000000000000000000008073 160.0
TLS2_k127_1892486_8 Preprotein translocase, YajC subunit K03210 - - 0.00000000000000000000000000001312 121.0
TLS2_k127_1892486_9 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000007403 113.0
TLS2_k127_1902055_0 ABC transporter K06147,K06148 - - 4.952e-266 831.0
TLS2_k127_1902055_1 Spermine/spermidine synthase domain K00797 - 2.5.1.16 5.074e-254 809.0
TLS2_k127_1902055_10 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 434.0
TLS2_k127_1902055_11 Belongs to the prokaryotic GSH synthase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 425.0
TLS2_k127_1902055_12 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006785 413.0
TLS2_k127_1902055_13 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004879 419.0
TLS2_k127_1902055_14 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 385.0
TLS2_k127_1902055_15 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009313 319.0
TLS2_k127_1902055_16 DUF1704 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000816 326.0
TLS2_k127_1902055_17 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 309.0
TLS2_k127_1902055_18 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007153 279.0
TLS2_k127_1902055_19 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003914 274.0
TLS2_k127_1902055_2 Protease II K01354 - 3.4.21.83 5.459e-239 757.0
TLS2_k127_1902055_20 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002214 252.0
TLS2_k127_1902055_21 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002796 253.0
TLS2_k127_1902055_22 COG2199 FOG GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000003182 224.0
TLS2_k127_1902055_23 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000006093 206.0
TLS2_k127_1902055_24 universal stress protein K14055 - - 0.000000000000000000000000000000000000000000002874 175.0
TLS2_k127_1902055_25 Protein of unknown function (DUF3187) - - - 0.0000000000000000000000000000000000005878 152.0
TLS2_k127_1902055_26 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000394 123.0
TLS2_k127_1902055_27 Protein required for attachment to host cells - - - 0.000000000000002895 83.0
TLS2_k127_1902055_29 - - - - 0.00000000000005355 79.0
TLS2_k127_1902055_3 Peptidase m28 - - - 6.838e-196 640.0
TLS2_k127_1902055_4 ABC-type transport system, involved in lipoprotein release, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 607.0
TLS2_k127_1902055_5 COG0793 Periplasmic protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 578.0
TLS2_k127_1902055_6 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 576.0
TLS2_k127_1902055_7 Peptidase dimerisation domain K01439,K13049 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 544.0
TLS2_k127_1902055_8 Glutathione S-transferase, C-terminal domain K07393 - 1.8.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 476.0
TLS2_k127_1902055_9 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 466.0
TLS2_k127_191137_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 1.177e-300 936.0
TLS2_k127_191137_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001057 278.0
TLS2_k127_1997787_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0 1176.0
TLS2_k127_1997787_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.438e-294 911.0
TLS2_k127_1997787_10 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000471 360.0
TLS2_k127_1997787_11 N-formylglutamate amidohydrolase K01458,K01479 - 3.5.1.68,3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001338 285.0
TLS2_k127_1997787_12 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004507 269.0
TLS2_k127_1997787_13 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells K03649 - 3.2.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000004293 263.0
TLS2_k127_1997787_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004832 256.0
TLS2_k127_1997787_15 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000002116 249.0
TLS2_k127_1997787_16 phosphoribosyltransferase K07101 - - 0.000000000000000000000000000000000000000000000000000000000000000000001923 240.0
TLS2_k127_1997787_17 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000003366 250.0
TLS2_k127_1997787_18 histidine utilization repressor K05836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000199 240.0
TLS2_k127_1997787_19 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000004729 214.0
TLS2_k127_1997787_2 TrkA-N domain K03455 - - 1.209e-271 850.0
TLS2_k127_1997787_20 EthD domain - - - 0.0000000000000000000000000000000000000000000000000000165 190.0
TLS2_k127_1997787_21 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000001462 192.0
TLS2_k127_1997787_22 Major facilitator superfamily K07552 - - 0.0000000000000000000000000000000000000000000005946 181.0
TLS2_k127_1997787_23 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000000000000000007358 169.0
TLS2_k127_1997787_24 Acetyltransferase (GNAT) domain K22441 - 2.3.1.57 0.0000000000000000000000000000000000000000001611 166.0
TLS2_k127_1997787_25 cytochrome - - - 0.0000000000000000000000004671 108.0
TLS2_k127_1997787_26 Predicted integral membrane protein (DUF2269) - - - 0.000000000000000000005855 98.0
TLS2_k127_1997787_3 Mo-co oxidoreductase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 604.0
TLS2_k127_1997787_4 Na H antiporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 574.0
TLS2_k127_1997787_5 Belongs to the thiolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 562.0
TLS2_k127_1997787_6 histidine ammonia-lyase activity K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 567.0
TLS2_k127_1997787_7 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 480.0
TLS2_k127_1997787_8 COG3202 ATP ADP translocase K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 454.0
TLS2_k127_1997787_9 Amidohydrolase family K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 398.0
TLS2_k127_2033140_0 Carbon starvation protein K06200 - - 0.0 1118.0
TLS2_k127_2033140_1 Di-haem cytochrome c peroxidase K00428 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 6.13e-280 922.0
TLS2_k127_2033140_10 small protein - - - 0.00000000000000000000001902 104.0
TLS2_k127_2033140_11 Type II transport protein GspH K08084 - - 0.000000000000000000000297 104.0
TLS2_k127_2033140_12 Type II transport protein GspH K08084 - - 0.0000000000000005467 86.0
TLS2_k127_2033140_13 COG4967 Tfp pilus assembly protein PilV - - - 0.000000000000001118 83.0
TLS2_k127_2033140_14 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03425 GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000005232 70.0
TLS2_k127_2033140_15 AI-2E family transporter - - - 0.00000000001651 66.0
TLS2_k127_2033140_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000231 64.0
TLS2_k127_2033140_17 Type IV Pilus-assembly protein W K02672 - - 0.00000004015 64.0
TLS2_k127_2033140_18 Phage integrase family - - - 0.000002702 50.0
TLS2_k127_2033140_19 rhs family - - - 0.00000805 61.0
TLS2_k127_2033140_2 amino acid K03294 - - 1.63e-242 756.0
TLS2_k127_2033140_21 Type IV pilus assembly protein PilX C-term K02673 - - 0.0005726 51.0
TLS2_k127_2033140_3 membrane protein, terc - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 8.955e-210 664.0
TLS2_k127_2033140_4 Sodium:dicarboxylate symporter family K03309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005889 376.0
TLS2_k127_2033140_5 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 340.0
TLS2_k127_2033140_6 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000000000000000000000001998 232.0
TLS2_k127_2033140_7 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000003356 223.0
TLS2_k127_2033140_8 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000000000000007121 175.0
TLS2_k127_2033140_9 belongs to the Fur family K09826 - - 0.00000000000000000000000000000000000003892 150.0
TLS2_k127_2038998_0 TIGRFAM RHS repeat-associated core domain-containing protein, YD repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008885 426.0
TLS2_k127_2045088_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1620.0
TLS2_k127_2045088_1 Heat shock 70 kDa protein K04043 - - 1.469e-320 990.0
TLS2_k127_2045088_10 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 501.0
TLS2_k127_2045088_11 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006585 485.0
TLS2_k127_2045088_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 471.0
TLS2_k127_2045088_13 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 316.0
TLS2_k127_2045088_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 307.0
TLS2_k127_2045088_15 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 291.0
TLS2_k127_2045088_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001829 282.0
TLS2_k127_2045088_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000448 258.0
TLS2_k127_2045088_18 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000005379 237.0
TLS2_k127_2045088_19 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000005658 240.0
TLS2_k127_2045088_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.634e-292 912.0
TLS2_k127_2045088_20 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000002993 236.0
TLS2_k127_2045088_21 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000001641 201.0
TLS2_k127_2045088_22 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000000000000000003038 179.0
TLS2_k127_2045088_23 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000002342 193.0
TLS2_k127_2045088_24 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000000000004609 151.0
TLS2_k127_2045088_25 preprotein translocase K03075 - - 0.00000000000000000001285 98.0
TLS2_k127_2045088_26 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000006312 57.0
TLS2_k127_2045088_3 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 4.452e-284 885.0
TLS2_k127_2045088_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 2.545e-249 772.0
TLS2_k127_2045088_5 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 1.928e-243 772.0
TLS2_k127_2045088_6 NADH ubiquinone oxidoreductase subunit K00342 - 1.6.5.3 9.93e-215 677.0
TLS2_k127_2045088_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.504e-206 650.0
TLS2_k127_2045088_8 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 533.0
TLS2_k127_2045088_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 519.0
TLS2_k127_2047832_0 OPT oligopeptide transporter protein - - - 2.294e-288 899.0
TLS2_k127_2047832_1 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.647e-238 747.0
TLS2_k127_2047832_2 TonB dependent receptor - - - 3e-222 715.0
TLS2_k127_2047832_3 COG0471 Di- and tricarboxylate transporters K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006511 523.0
TLS2_k127_2047832_4 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 497.0
TLS2_k127_2047832_5 NADP-dependent oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 362.0
TLS2_k127_2047832_6 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000006524 206.0
TLS2_k127_2047832_7 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.00000000000000000000000000000000000000000000000004713 184.0
TLS2_k127_2047832_8 Glutaredoxin K03386 - 1.11.1.15 0.000000000000000000000000001267 113.0
TLS2_k127_2047832_9 Domain of unknown function (DUF4437) - - - 0.00003488 53.0
TLS2_k127_2053412_0 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 289.0
TLS2_k127_2053412_1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000002165 214.0
TLS2_k127_2053412_2 COG1051 ADP-ribose pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000007434 207.0
TLS2_k127_2053412_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000009132 141.0
TLS2_k127_2058027_0 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 451.0
TLS2_k127_2058027_1 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000001796 141.0
TLS2_k127_2058027_2 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000000000000004379 139.0
TLS2_k127_2058027_3 copG family - - - 0.000000000000000000007122 94.0
TLS2_k127_2085165_0 Lipoprotein releasing system transmembrane protein K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005931 426.0
TLS2_k127_2085165_1 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 362.0
TLS2_k127_2085165_2 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004145 283.0
TLS2_k127_2085165_3 Protein conserved in bacteria K09928 - - 0.00000000000004352 74.0
TLS2_k127_2085165_4 - - - - 0.0000000000002244 76.0
TLS2_k127_2092391_0 Single-stranded-DNA-specific exonuclease K07462 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 549.0
TLS2_k127_2092391_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 524.0
TLS2_k127_2092391_10 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.000000000000000006907 86.0
TLS2_k127_2092391_11 Protein conserved in bacteria - - - 0.000000000002674 78.0
TLS2_k127_2092391_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 335.0
TLS2_k127_2092391_3 Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs K06176 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 321.0
TLS2_k127_2092391_4 RNA polymerase sigma factor RpoS K03087 GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006705 311.0
TLS2_k127_2092391_5 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006631 257.0
TLS2_k127_2092391_6 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000001329 257.0
TLS2_k127_2092391_7 peptidase K06194 - - 0.000000000000000000000000000000000000000000000001486 190.0
TLS2_k127_2092391_8 Smr protein - - - 0.000000000000000000000000000000000000002478 154.0
TLS2_k127_2092391_9 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000363 106.0
TLS2_k127_2093138_0 Zn-dependent peptidases K07263 - - 0.0 1030.0
TLS2_k127_2093138_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K20034 - 6.2.1.44 1.205e-228 719.0
TLS2_k127_2093138_10 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019,K18335 - 1.1.1.30 0.0000000000000000000000000000000000000008649 158.0
TLS2_k127_2093138_11 membrane - - - 0.0000000000000000000000000002657 134.0
TLS2_k127_2093138_12 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.0000000000000000000003642 105.0
TLS2_k127_2093138_13 YKOF-related Family - - - 0.00000000000000000118 87.0
TLS2_k127_2093138_14 Phosphotransferase enzyme family K07251 - 2.7.1.89 0.0000000000002978 80.0
TLS2_k127_2093138_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.916e-225 725.0
TLS2_k127_2093138_3 Sodium/hydrogen exchanger family - - - 9.899e-204 640.0
TLS2_k127_2093138_4 TonB-dependent receptor plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 605.0
TLS2_k127_2093138_5 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 406.0
TLS2_k127_2093138_6 Acyl-CoA thioesterase K10805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 368.0
TLS2_k127_2093138_7 Nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000000000000004687 205.0
TLS2_k127_2093138_8 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000006142 175.0
TLS2_k127_2093138_9 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000000000000000002318 159.0
TLS2_k127_209481_0 Outer membrane protein beta-barrel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007462 576.0
TLS2_k127_209481_1 protein methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003321 282.0
TLS2_k127_209481_2 Helix-turn-helix domain, rpiR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002436 271.0
TLS2_k127_209481_3 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001593 269.0
TLS2_k127_209481_4 Forkhead associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000845 219.0
TLS2_k127_209481_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000001037 190.0
TLS2_k127_209481_6 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.00000000000000000000000000000000000000006323 155.0
TLS2_k127_2107648_0 His Kinase A (phosphoacceptor) domain - - - 2.844e-200 678.0
TLS2_k127_2107648_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 294.0
TLS2_k127_2107648_2 protein conserved in bacteria - - - 0.000000000000000000000000000000000000005584 156.0
TLS2_k127_2111616_0 COG2217 Cation transport ATPase K17686 - 3.6.3.54 0.0 1025.0
TLS2_k127_2111616_1 Copper-binding protein - - - 3.556e-286 887.0
TLS2_k127_2111616_10 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000006105 137.0
TLS2_k127_2111616_11 Protein of unknown function (DUF3703) - - - 0.00000000000000000000000000002911 121.0
TLS2_k127_2111616_12 Metal-sensitive transcriptional repressor K21600 - - 0.0000000000000000000000000003639 120.0
TLS2_k127_2111616_2 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 470.0
TLS2_k127_2111616_3 Copper resistance K07233 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 321.0
TLS2_k127_2111616_4 nuclear chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002794 300.0
TLS2_k127_2111616_5 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003265 260.0
TLS2_k127_2111616_6 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000001939 219.0
TLS2_k127_2111616_7 - - - - 0.0000000000000000000000000000000000000000000001604 171.0
TLS2_k127_2111616_8 - - - - 0.00000000000000000000000000000000000000003452 160.0
TLS2_k127_2111616_9 Uncharacterized ACR, COG1678 - - - 0.0000000000000000000000000000000000008517 147.0
TLS2_k127_2119668_0 TonB-dependent siderophore receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007748 483.0
TLS2_k127_2120613_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1105.0
TLS2_k127_2120613_1 DALR_2 K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 584.0
TLS2_k127_2120613_2 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000007103 239.0
TLS2_k127_2120613_3 DNA polymerase III delta subunit K02340 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0000000000000000000000000000000000000000000000008303 179.0
TLS2_k127_2120613_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000002451 115.0
TLS2_k127_2120613_5 Trm112p-like protein - - - 0.0000000000000000004486 91.0
TLS2_k127_2120613_6 - - - - 0.000000000000001806 85.0
TLS2_k127_2120613_7 MerC mercury resistance protein - - - 0.000000000000002581 81.0
TLS2_k127_2120613_8 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000000008147 82.0
TLS2_k127_213488_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 619.0
TLS2_k127_213488_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 515.0
TLS2_k127_213488_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481,K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 504.0
TLS2_k127_213488_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0019538,GO:0032991,GO:0036211,GO:0042709,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0046777,GO:0071704,GO:1901564,GO:1902494 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 433.0
TLS2_k127_213488_4 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 384.0
TLS2_k127_213488_5 Histidine kinase K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 383.0
TLS2_k127_213488_6 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000002793 264.0
TLS2_k127_213488_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000000000001511 216.0
TLS2_k127_213488_8 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.00000000000000000000000000000000000000000000000000002573 191.0
TLS2_k127_213488_9 RES - - - 0.00000009774 59.0
TLS2_k127_2147659_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005137 610.0
TLS2_k127_2147659_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 593.0
TLS2_k127_2147659_10 Glycosyl Transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007684 253.0
TLS2_k127_2147659_11 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000002287 216.0
TLS2_k127_2147659_12 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000003428 222.0
TLS2_k127_2147659_13 HupE / UreJ protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000002055 184.0
TLS2_k127_2147659_14 PFAM methyltransferase - - - 0.00000000000000000000000000000000000004842 152.0
TLS2_k127_2147659_15 peptidyl-prolyl isomerase K03770 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 0.00000000000000000000001778 110.0
TLS2_k127_2147659_2 Belongs to the GPI family K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 544.0
TLS2_k127_2147659_3 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007353 528.0
TLS2_k127_2147659_4 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 521.0
TLS2_k127_2147659_5 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K11102 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 509.0
TLS2_k127_2147659_6 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 458.0
TLS2_k127_2147659_7 Capsule assembly protein Wzi - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 401.0
TLS2_k127_2147659_8 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 374.0
TLS2_k127_2147659_9 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342,K14159 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000736 272.0
TLS2_k127_2158650_0 TrkA-C domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 371.0
TLS2_k127_2158650_1 Trehalose utilisation - - - 0.00000000000000000000000000000000000000000000000009868 189.0
TLS2_k127_2158650_2 protein involved in outer membrane biogenesis K07290 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - 0.0000000000000000000006244 111.0
TLS2_k127_2158650_3 MlaA lipoprotein K04754 - - 0.0000000000001837 75.0
TLS2_k127_217545_0 Efflux pump membrane transporter K03296,K18138 - - 0.0 1221.0
TLS2_k127_217545_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006147 552.0
TLS2_k127_217545_10 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 294.0
TLS2_k127_217545_11 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003452 252.0
TLS2_k127_217545_12 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000004197 259.0
TLS2_k127_217545_13 BetI-type transcriptional repressor, C-terminal - - - 0.00000000000000000000000000000000000000000000000000000000156 206.0
TLS2_k127_217545_14 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000007048 177.0
TLS2_k127_217545_15 protein conserved in bacteria K09984 - - 0.000000000000000000000000000000000000000000000001533 175.0
TLS2_k127_217545_16 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000007442 171.0
TLS2_k127_217545_17 Transcriptional regulator - - - 0.00000000000000000000008663 104.0
TLS2_k127_217545_2 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 525.0
TLS2_k127_217545_3 Methyltransferase K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 490.0
TLS2_k127_217545_4 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007594 499.0
TLS2_k127_217545_5 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007731 464.0
TLS2_k127_217545_6 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 475.0
TLS2_k127_217545_7 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 414.0
TLS2_k127_217545_8 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 353.0
TLS2_k127_217545_9 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009699 334.0
TLS2_k127_2177011_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 536.0
TLS2_k127_2177011_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 529.0
TLS2_k127_2177011_10 - - - - 0.00001083 51.0
TLS2_k127_2177011_2 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 405.0
TLS2_k127_2177011_3 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 409.0
TLS2_k127_2177011_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000003376 239.0
TLS2_k127_2177011_5 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000004475 207.0
TLS2_k127_2177011_6 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000009265 181.0
TLS2_k127_2177011_7 Cytotoxic translational repressor of toxin-antitoxin stability system - - - 0.00000000000000000000000000000000000009949 144.0
TLS2_k127_2177011_8 Helix-turn-helix XRE-family like proteins K07726 - - 0.000000000000000000000000000000000001927 139.0
TLS2_k127_2177011_9 Cupin domain - - - 0.0000000000000000000000000000006534 133.0
TLS2_k127_2212194_0 cAMP biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 354.0
TLS2_k127_2289728_0 IS66 C-terminal element - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 329.0
TLS2_k127_2289728_1 Wzt C-terminal domain K09691 - - 0.000000000000000000000000000000000000000000000000000000001045 205.0
TLS2_k127_2445373_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1032.0
TLS2_k127_2445373_1 ABC transporter K15738 - - 7.603e-245 772.0
TLS2_k127_2445373_10 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000003654 217.0
TLS2_k127_2445373_11 MafB19-like deaminase K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000000000000004587 217.0
TLS2_k127_2445373_12 of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000000000000004737 221.0
TLS2_k127_2445373_13 PFAM OsmC family protein K04063 - - 0.000000000000000000000000000000000000000000000000000000000007426 210.0
TLS2_k127_2445373_14 Putative tRNA binding domain K06878 - - 0.00000000000000000000000000000000000000000000004732 172.0
TLS2_k127_2445373_15 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000002642 157.0
TLS2_k127_2445373_16 cellular manganese ion homeostasis - - - 0.000000000000000000000000000000000000001768 152.0
TLS2_k127_2445373_17 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000001212 143.0
TLS2_k127_2445373_18 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000000000001747 132.0
TLS2_k127_2445373_19 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000001304 133.0
TLS2_k127_2445373_2 Sodium:dicarboxylate symporter family K06956 GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009315 539.0
TLS2_k127_2445373_20 SlyX K03745 - - 0.000001623 52.0
TLS2_k127_2445373_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 477.0
TLS2_k127_2445373_4 Splits dipeptides with a prolyl residue in the C- terminal position K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 451.0
TLS2_k127_2445373_5 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 294.0
TLS2_k127_2445373_6 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005273 281.0
TLS2_k127_2445373_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006903 259.0
TLS2_k127_2445373_8 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003713 253.0
TLS2_k127_2445373_9 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000006442 237.0
TLS2_k127_2530867_0 Bacterial regulatory helix-turn-helix protein, lysR family K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000002279 233.0
TLS2_k127_2530867_1 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000005179 173.0
TLS2_k127_2530867_2 - - - - 0.00000005442 63.0
TLS2_k127_2530867_3 Uncharacterized ACR, COG1399 K07040 - - 0.000002182 57.0
TLS2_k127_2603693_0 DNA ligase K01971 - 6.5.1.1 1.623e-313 980.0
TLS2_k127_2603693_1 Aldehyde dehydrogenase family K00128 - 1.2.1.3 3.162e-201 638.0
TLS2_k127_2603693_10 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000001049 175.0
TLS2_k127_2603693_11 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000472 157.0
TLS2_k127_2603693_12 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000000004451 145.0
TLS2_k127_2603693_13 MgtC family K07507 - - 0.000000000000000000000000000001422 128.0
TLS2_k127_2603693_14 Protein involved in outer membrane biogenesis - - - 0.000000000000000000000000009045 120.0
TLS2_k127_2603693_15 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000001391 105.0
TLS2_k127_2603693_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 575.0
TLS2_k127_2603693_3 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 491.0
TLS2_k127_2603693_4 KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007766 448.0
TLS2_k127_2603693_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007913 373.0
TLS2_k127_2603693_6 alpha,alpha-trehalose-phosphate synthase K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 346.0
TLS2_k127_2603693_7 two-component system sensor protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 346.0
TLS2_k127_2603693_8 DJ-1/PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004819 270.0
TLS2_k127_2603693_9 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002081 251.0
TLS2_k127_268401_0 short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 510.0
TLS2_k127_268401_1 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 471.0
TLS2_k127_268401_10 Multidrug Resistance protein K03297 - - 0.000000000000000000002514 104.0
TLS2_k127_268401_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 450.0
TLS2_k127_268401_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 392.0
TLS2_k127_268401_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000243 239.0
TLS2_k127_268401_5 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000006256 214.0
TLS2_k127_268401_6 Domain of unknown function (DUF4401) - - - 0.0000000000000000000000000000000000000000000000005565 190.0
TLS2_k127_268401_7 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000006831 177.0
TLS2_k127_268401_8 GDYXXLXY protein - - - 0.0000000000000000000000000000000008052 136.0
TLS2_k127_268401_9 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000001295 130.0
TLS2_k127_2694355_0 PFAM Glycosyl transferase family 2 K03669 - - 1.74e-238 764.0
TLS2_k127_2694355_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 8.24e-206 652.0
TLS2_k127_2694355_2 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 594.0
TLS2_k127_2694355_3 RNA-metabolising metallo-beta-lactamase K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 571.0
TLS2_k127_2694355_4 alcohol dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 446.0
TLS2_k127_2694355_5 PFAM Mg2 transporter protein CorA family protein K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 411.0
TLS2_k127_2694355_6 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 367.0
TLS2_k127_2694355_7 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000005787 111.0
TLS2_k127_2694355_8 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000003208 100.0
TLS2_k127_2694355_9 general secretion pathway protein D K02453 - - 0.000000005748 63.0
TLS2_k127_2698549_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1183.0
TLS2_k127_2698549_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1120.0
TLS2_k127_2698549_10 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 505.0
TLS2_k127_2698549_11 Aminotransferase class-V K14287 - 2.6.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 492.0
TLS2_k127_2698549_12 Belongs to the class I fructose-bisphosphate aldolase family K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 439.0
TLS2_k127_2698549_13 FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 360.0
TLS2_k127_2698549_14 PFAM ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 352.0
TLS2_k127_2698549_15 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 340.0
TLS2_k127_2698549_16 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 320.0
TLS2_k127_2698549_17 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 325.0
TLS2_k127_2698549_18 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 298.0
TLS2_k127_2698549_19 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001686 287.0
TLS2_k127_2698549_2 TIGRFAM FeS assembly protein SufB K09014 - - 2.865e-265 830.0
TLS2_k127_2698549_20 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006391 279.0
TLS2_k127_2698549_21 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004242 274.0
TLS2_k127_2698549_22 Carbon-nitrogen hydrolase K11206,K13566 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050152,GO:0071944,GO:0106008 3.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001017 278.0
TLS2_k127_2698549_23 FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005385 282.0
TLS2_k127_2698549_24 TIGRFAM FeS assembly SUF system protein SufT - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001218 260.0
TLS2_k127_2698549_25 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005893 256.0
TLS2_k127_2698549_26 Phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001955 260.0
TLS2_k127_2698549_27 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000001188 248.0
TLS2_k127_2698549_28 Peroxiredoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000003172 212.0
TLS2_k127_2698549_29 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000002402 220.0
TLS2_k127_2698549_3 Dehydrogenase K00294 GO:0003674,GO:0003824,GO:0003842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006536,GO:0006560,GO:0006562,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009507,GO:0009536,GO:0009628,GO:0009651,GO:0009987,GO:0010133,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019752,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0055114,GO:0071704,GO:0072593,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.88 7.526e-201 641.0
TLS2_k127_2698549_30 Bacterial SH3 domain homologues K07184 - - 0.0000000000000000000000000000000000000000000000000000000001414 213.0
TLS2_k127_2698549_31 PFAM VacJ family lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000289 209.0
TLS2_k127_2698549_32 PFAM Amino acid-binding ACT K03567 - - 0.00000000000000000000000000000000000000000000000000000003653 203.0
TLS2_k127_2698549_33 Protein of unknown function (DUF938) - - - 0.000000000000000000000000000000000000000000000000000007476 195.0
TLS2_k127_2698549_34 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000004606 188.0
TLS2_k127_2698549_35 Scavenger mRNA decapping enzyme C-term binding K02503 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - 0.00000000000000000000000000000000000000000000009174 170.0
TLS2_k127_2698549_36 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000003093 165.0
TLS2_k127_2698549_37 PFAM Phosphoglycerate mutase K08296 - - 0.0000000000000000000000000000000000000003928 155.0
TLS2_k127_2698549_38 TIGRFAM SUF system FeS K04488 - - 0.0000000000000000000000000000000000000009563 156.0
TLS2_k127_2698549_39 ABC-type transport system involved in resistance to organic solvents auxiliary component K07323 - - 0.000000000000000000000000000000000000002478 154.0
TLS2_k127_2698549_4 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 543.0
TLS2_k127_2698549_40 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000001881 146.0
TLS2_k127_2698549_41 transcriptional regulator - - - 0.00000000000000000000000000000000003962 139.0
TLS2_k127_2698549_42 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.000000000000000000000002343 110.0
TLS2_k127_2698549_43 - - - - 0.000000000000009763 85.0
TLS2_k127_2698549_44 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00000000005285 63.0
TLS2_k127_2698549_45 NTP binding protein (Contains STAS domain) K07122 - - 0.000000001202 65.0
TLS2_k127_2698549_5 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 537.0
TLS2_k127_2698549_6 L-Serine dehydratase K01752 - 4.3.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 537.0
TLS2_k127_2698549_7 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 534.0
TLS2_k127_2698549_8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 531.0
TLS2_k127_2698549_9 COG0616 Periplasmic serine proteases (ClpP class) K04773 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 513.0
TLS2_k127_2722814_0 Outer membrane receptor K02014 - - 1.56e-318 991.0
TLS2_k127_2722814_1 COG1541 Coenzyme F390 synthetase - - - 1.588e-220 690.0
TLS2_k127_2722814_10 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 503.0
TLS2_k127_2722814_11 saccharopine dehydrogenase activity K00290 - 1.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 438.0
TLS2_k127_2722814_12 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005872 410.0
TLS2_k127_2722814_13 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 366.0
TLS2_k127_2722814_14 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 358.0
TLS2_k127_2722814_15 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 339.0
TLS2_k127_2722814_16 transcriptional regulator K02624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 341.0
TLS2_k127_2722814_17 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 314.0
TLS2_k127_2722814_18 COG2513 PEP phosphonomutase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 312.0
TLS2_k127_2722814_19 PFAM MazG nucleotide pyrophosphohydrolase K04765 - 3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 304.0
TLS2_k127_2722814_2 Belongs to the malate synthase family K01638 - 2.3.3.9 4.039e-216 683.0
TLS2_k127_2722814_20 uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 292.0
TLS2_k127_2722814_21 Histidine kinase K07637 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 295.0
TLS2_k127_2722814_22 citrate synthase K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001148 284.0
TLS2_k127_2722814_23 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000248 277.0
TLS2_k127_2722814_24 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000003022 219.0
TLS2_k127_2722814_25 Alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000001621 218.0
TLS2_k127_2722814_26 COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000002303 206.0
TLS2_k127_2722814_27 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000001706 196.0
TLS2_k127_2722814_28 NAD(P)H-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000003089 177.0
TLS2_k127_2722814_29 HDOD domain - - - 0.00000000000000000000000000000000000000002342 165.0
TLS2_k127_2722814_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 7.615e-216 690.0
TLS2_k127_2722814_30 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000000009973 150.0
TLS2_k127_2722814_31 DNA mismatch repair protein MutT - - - 0.000000000000000000000000000000000000001798 156.0
TLS2_k127_2722814_32 Outer membrane lipoprotein - - - 0.000000000000000000000003687 113.0
TLS2_k127_2722814_34 Belongs to the SAICAR synthetase family K01923,K01945 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.0004981 44.0
TLS2_k127_2722814_4 Aldehyde dehydrogenase family K00128 - 1.2.1.3 7.547e-215 679.0
TLS2_k127_2722814_5 Isocitrate K00031 GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 1.11e-197 626.0
TLS2_k127_2722814_6 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 607.0
TLS2_k127_2722814_7 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 606.0
TLS2_k127_2722814_8 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 587.0
TLS2_k127_2722814_9 E COG0620 Methionine synthase II (cobalamin-independent) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009241 523.0
TLS2_k127_2738006_0 Outer membrane receptor proteins mostly Fe transport - - - 1.023e-268 856.0
TLS2_k127_2738006_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 6.47e-258 805.0
TLS2_k127_2738006_10 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 336.0
TLS2_k127_2738006_11 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 327.0
TLS2_k127_2738006_12 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009675 278.0
TLS2_k127_2738006_13 COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000000000000000000000000000000000000004913 241.0
TLS2_k127_2738006_14 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000002899 196.0
TLS2_k127_2738006_15 Tripartite ATP-independent periplasmic transporter, DctQ - - - 0.000000000000000000000000000000000000000000000005879 177.0
TLS2_k127_2738006_16 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685,K01708 - 4.2.1.42,4.2.1.7 0.0000000003301 65.0
TLS2_k127_2738006_2 Glucuronate isomerase K01812 - 5.3.1.12 5.366e-222 696.0
TLS2_k127_2738006_3 pectate lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 599.0
TLS2_k127_2738006_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 557.0
TLS2_k127_2738006_5 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 494.0
TLS2_k127_2738006_6 Mannitol dehydrogenase K00040 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 1.1.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005119 515.0
TLS2_k127_2738006_7 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate K01815 - 5.3.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002696 458.0
TLS2_k127_2738006_8 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K21395 GO:0003674,GO:0005488,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0030246,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 415.0
TLS2_k127_2738006_9 lacI family K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 396.0
TLS2_k127_2742280_0 peptidase M24B, X-Pro dipeptidase aminopeptidase K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 575.0
TLS2_k127_2742280_1 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008656 373.0
TLS2_k127_2742280_10 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000556 100.0
TLS2_k127_2742280_11 Belongs to the UPF0149 family K09895 - - 0.000000000000000000001352 102.0
TLS2_k127_2742280_12 TIGRFAM TIGR02449 family protein K09892 - - 0.000000000001419 70.0
TLS2_k127_2742280_13 Squalene epoxidase K18800 - - 0.0000000005043 68.0
TLS2_k127_2742280_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007656 356.0
TLS2_k127_2742280_3 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 284.0
TLS2_k127_2742280_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003057 275.0
TLS2_k127_2742280_5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000000000000000000004169 241.0
TLS2_k127_2742280_6 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000000000003596 222.0
TLS2_k127_2742280_7 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000001618 205.0
TLS2_k127_2742280_8 salt-induced outer membrane protein K07283 - - 0.00000000000000000000000000000000000000000000004374 181.0
TLS2_k127_2742280_9 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000000000000000001132 141.0
TLS2_k127_2743220_0 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 513.0
TLS2_k127_2743220_1 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 415.0
TLS2_k127_2743220_2 ribonuclease BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 347.0
TLS2_k127_2743220_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000003547 226.0
TLS2_k127_2743220_4 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 - - 0.0000000000000000000000000000000000000000006929 167.0
TLS2_k127_2743220_5 Protein of unknown function (DUF615) K09889 - - 0.00000000000000000001558 98.0
TLS2_k127_2745917_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1673.0
TLS2_k127_2745917_1 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 3.466e-253 790.0
TLS2_k127_2745917_10 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000002917 204.0
TLS2_k127_2745917_11 Redoxin - - - 0.00000000000000000000000000000000000000000001008 173.0
TLS2_k127_2745917_12 luxr family transcriptional regulator - - - 0.00000000000000000000000000000000000000000001252 174.0
TLS2_k127_2745917_13 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000002212 130.0
TLS2_k127_2745917_14 Thioesterase superfamily - - - 0.00000000000005938 78.0
TLS2_k127_2745917_15 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000002902 61.0
TLS2_k127_2745917_16 Sel1-like repeats. - - - 0.00008498 53.0
TLS2_k127_2745917_2 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 6.56e-247 786.0
TLS2_k127_2745917_3 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 581.0
TLS2_k127_2745917_4 Acyl-CoA dehydrogenase, middle domain K00253 - 1.3.8.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 571.0
TLS2_k127_2745917_5 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 485.0
TLS2_k127_2745917_6 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008508 399.0
TLS2_k127_2745917_7 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008635 299.0
TLS2_k127_2745917_8 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003984 252.0
TLS2_k127_2745917_9 Enoyl-CoA hydratase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000006405 236.0
TLS2_k127_28043_0 Glycosyl hydrolases family 31 K01811 - 3.2.1.177 7.048e-310 967.0
TLS2_k127_28043_1 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 527.0
TLS2_k127_28043_2 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000000000000000000001033 189.0
TLS2_k127_28043_3 - - - - 0.000000000000000000000000000000008005 135.0
TLS2_k127_28043_4 molecular chaperone K05516 - - 0.0000000000000000001616 89.0
TLS2_k127_28043_5 Protein of unknown function (DUF3307) - - - 0.00000000000000001072 93.0
TLS2_k127_28043_6 SatD family (SatD) - - - 0.00000000002282 76.0
TLS2_k127_28043_7 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000004067 69.0
TLS2_k127_28043_8 Protein of unknown function (DUF3096) - - - 0.00000001045 59.0
TLS2_k127_2809556_0 Catalyzes the NAD( )-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non- methylotrophic organisms K00122 - 1.17.1.9 3.138e-206 647.0
TLS2_k127_2809556_1 receptor - - - 1.176e-202 661.0
TLS2_k127_2809556_10 - - - - 0.0000000000000000000000000000000000000000000000000000186 195.0
TLS2_k127_2809556_11 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000005613 194.0
TLS2_k127_2809556_12 Cytochrome c K08738 - - 0.000000000000000000000000000000001134 135.0
TLS2_k127_2809556_14 - - - - 0.00000000000000005732 86.0
TLS2_k127_2809556_15 - - - - 0.00000000000001793 85.0
TLS2_k127_2809556_16 Metallo-beta-lactamase superfamily - - - 0.00000000002012 69.0
TLS2_k127_2809556_17 Ca2 -binding protein (EF-Hand superfamily - - - 0.0000006028 59.0
TLS2_k127_2809556_2 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 1.383e-200 630.0
TLS2_k127_2809556_3 Monoamine oxidase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 563.0
TLS2_k127_2809556_4 xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 487.0
TLS2_k127_2809556_5 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 365.0
TLS2_k127_2809556_6 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004753 370.0
TLS2_k127_2809556_7 cytochrome b561 K12262 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007314 266.0
TLS2_k127_2809556_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000853 220.0
TLS2_k127_2809556_9 Translation Initiation Inhibitor YjgF Family - - - 0.00000000000000000000000000000000000000000000000000000000001535 210.0
TLS2_k127_2830515_0 Glutamate synthase K00265 GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 0.0 1364.0
TLS2_k127_2830515_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 600.0
TLS2_k127_2830515_10 Exodeoxyribonuclease IX - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 295.0
TLS2_k127_2830515_11 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003113 280.0
TLS2_k127_2830515_12 PFAM Bacterial protein of - - - 0.00000000000000000000000000000000000000000000004739 180.0
TLS2_k127_2830515_13 NADP transhydrogenase K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000003411 159.0
TLS2_k127_2830515_14 - - - - 0.00000000000009527 81.0
TLS2_k127_2830515_15 Late embryogenesis abundant protein - - - 0.0000171 55.0
TLS2_k127_2830515_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 599.0
TLS2_k127_2830515_3 Sodium alanine symporter K03310 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 569.0
TLS2_k127_2830515_4 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 531.0
TLS2_k127_2830515_5 COG0520 Selenocysteine lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 522.0
TLS2_k127_2830515_6 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 437.0
TLS2_k127_2830515_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 389.0
TLS2_k127_2830515_8 multidrug K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 361.0
TLS2_k127_2830515_9 PFAM HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 291.0
TLS2_k127_2856250_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1048.0
TLS2_k127_2856250_1 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 2.066e-266 831.0
TLS2_k127_2856250_10 Peptidase inhibitor I9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 595.0
TLS2_k127_2856250_11 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 537.0
TLS2_k127_2856250_12 Sodium alanine symporter K03310 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 538.0
TLS2_k127_2856250_13 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 511.0
TLS2_k127_2856250_14 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 488.0
TLS2_k127_2856250_15 response regulator receiver K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 449.0
TLS2_k127_2856250_16 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 445.0
TLS2_k127_2856250_17 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 439.0
TLS2_k127_2856250_18 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 419.0
TLS2_k127_2856250_19 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 413.0
TLS2_k127_2856250_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 5.553e-253 794.0
TLS2_k127_2856250_20 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 390.0
TLS2_k127_2856250_21 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 387.0
TLS2_k127_2856250_22 Belongs to the DapA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 363.0
TLS2_k127_2856250_23 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 378.0
TLS2_k127_2856250_24 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008389 359.0
TLS2_k127_2856250_25 PFAM Endonuclease Exonuclease phosphatase K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 343.0
TLS2_k127_2856250_26 Belongs to the D-alanine--D-alanine ligase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 320.0
TLS2_k127_2856250_27 Integral membrane protein TerC family K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 315.0
TLS2_k127_2856250_28 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 322.0
TLS2_k127_2856250_29 Catalyzes the synthesis of activated sulfate K00860,K00958 - 2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 319.0
TLS2_k127_2856250_3 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.491e-217 689.0
TLS2_k127_2856250_30 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 313.0
TLS2_k127_2856250_31 Lysin motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 316.0
TLS2_k127_2856250_32 regulator K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 297.0
TLS2_k127_2856250_33 D-aminopeptidase K16203 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 300.0
TLS2_k127_2856250_34 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 296.0
TLS2_k127_2856250_35 Bacterial capsule synthesis protein PGA_cap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 295.0
TLS2_k127_2856250_36 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002544 283.0
TLS2_k127_2856250_37 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000482 278.0
TLS2_k127_2856250_38 DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000173 265.0
TLS2_k127_2856250_39 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002923 251.0
TLS2_k127_2856250_4 peptidase K01414 - 3.4.24.70 1.271e-211 679.0
TLS2_k127_2856250_40 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000002468 228.0
TLS2_k127_2856250_41 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000002455 220.0
TLS2_k127_2856250_42 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000001201 220.0
TLS2_k127_2856250_43 Protein of unknown function (DUF3450) - - - 0.00000000000000000000000000000000000000000000000000000000006321 214.0
TLS2_k127_2856250_44 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000003074 213.0
TLS2_k127_2856250_45 Biopolymer transport protein ExbD/TolR - - - 0.000000000000000000000000000000000000000000000000000003063 193.0
TLS2_k127_2856250_46 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000006222 192.0
TLS2_k127_2856250_47 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000003627 177.0
TLS2_k127_2856250_48 Belongs to the Smg family K03747 - - 0.00000000000000000000000000000000000000000000004693 173.0
TLS2_k127_2856250_49 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000003637 166.0
TLS2_k127_2856250_5 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.1e-209 674.0
TLS2_k127_2856250_50 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000001815 163.0
TLS2_k127_2856250_51 Sporulation related domain - - - 0.00000000000000000000000000000000006934 141.0
TLS2_k127_2856250_52 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000004874 139.0
TLS2_k127_2856250_53 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000003443 130.0
TLS2_k127_2856250_54 Domain of unknown function (DUF4390) - - - 0.000000000000000000000000000003082 127.0
TLS2_k127_2856250_55 Biopolymer transport protein ExbD/TolR K03559 - - 0.000000000000000000000000000007761 123.0
TLS2_k127_2856250_56 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000001834 116.0
TLS2_k127_2856250_57 RNA-binding - - - 0.0000000000000000000000002609 111.0
TLS2_k127_2856250_58 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000002405 92.0
TLS2_k127_2856250_59 - - - - 0.0000000000000000004393 93.0
TLS2_k127_2856250_6 Radical SAM superfamily K01843 - 5.4.3.2 1.79e-203 642.0
TLS2_k127_2856250_61 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000006153 68.0
TLS2_k127_2856250_62 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000249 72.0
TLS2_k127_2856250_63 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03425 GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000008269 66.0
TLS2_k127_2856250_64 Protein of unknown function (DUF3379) - - - 0.000000001118 69.0
TLS2_k127_2856250_65 Psort location CytoplasmicMembrane, score 9.46 - - - 0.000002012 57.0
TLS2_k127_2856250_7 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 5.376e-201 631.0
TLS2_k127_2856250_8 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 620.0
TLS2_k127_2856250_9 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 571.0
TLS2_k127_2866144_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006376 590.0
TLS2_k127_2866144_1 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 563.0
TLS2_k127_2866144_10 Forkhead associated domain - - - 0.000000000139 75.0
TLS2_k127_2866144_11 - - - - 0.0003809 48.0
TLS2_k127_2866144_2 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 454.0
TLS2_k127_2866144_3 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 412.0
TLS2_k127_2866144_4 protease with the C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 318.0
TLS2_k127_2866144_5 - - - - 0.0000000000000000000000000000000000000000000000000000000006048 210.0
TLS2_k127_2866144_6 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000000000000000005443 169.0
TLS2_k127_2866144_7 Protein of unknown function (DUF1249) K09920 - - 0.000000000000000000000000002045 119.0
TLS2_k127_2866144_8 - - - - 0.0000000000000000000001981 106.0
TLS2_k127_2866144_9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772 2.7.11.33,2.7.4.28 0.000000000000000000227 89.0
TLS2_k127_2870077_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 4.322e-210 665.0
TLS2_k127_2870077_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822,K00833 - 2.6.1.18,2.6.1.62 8.073e-199 628.0
TLS2_k127_2870077_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256 - 2.6.1.113 3.937e-194 616.0
TLS2_k127_2870077_3 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 492.0
TLS2_k127_2870077_4 Belongs to the arginase family K01479,K01480,K12255 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11,3.5.3.7,3.5.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 454.0
TLS2_k127_2870077_5 Methylenetetrahydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 288.0
TLS2_k127_2870077_6 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000256 225.0
TLS2_k127_2872964_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 4.135e-228 737.0
TLS2_k127_2872964_1 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006239 603.0
TLS2_k127_2872964_10 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004873 269.0
TLS2_k127_2872964_11 sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000004881 206.0
TLS2_k127_2872964_12 COG1309 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000001922 194.0
TLS2_k127_2872964_13 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000004838 190.0
TLS2_k127_2872964_14 Glycosyl hydrolase family 12 - - - 0.00000000000000000000000000000000000000000000009761 181.0
TLS2_k127_2872964_15 Carbon-nitrogen hydrolase K03820 - - 0.00000000000000000000000000000000000000008518 162.0
TLS2_k127_2872964_16 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000000000000003168 154.0
TLS2_k127_2872964_17 CHRD domain - - - 0.0000000000000000000000001123 113.0
TLS2_k127_2872964_18 Tetratricopeptide repeat - - - 0.0000000000000000000000004262 118.0
TLS2_k127_2872964_19 alpha beta - - - 0.0000000000000000000000004542 121.0
TLS2_k127_2872964_2 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004679 554.0
TLS2_k127_2872964_20 DsrE/DsrF-like family - - - 0.00000000000000000006695 91.0
TLS2_k127_2872964_21 Integrase - - - 0.000000000000006194 77.0
TLS2_k127_2872964_22 - - - - 0.0000000000000844 74.0
TLS2_k127_2872964_24 - - - - 0.000002119 53.0
TLS2_k127_2872964_25 PFAM amidohydrolase - - - 0.0000107 54.0
TLS2_k127_2872964_26 Amidohydrolase family - - - 0.00004269 48.0
TLS2_k127_2872964_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 481.0
TLS2_k127_2872964_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 388.0
TLS2_k127_2872964_5 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007329 377.0
TLS2_k127_2872964_6 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 358.0
TLS2_k127_2872964_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 351.0
TLS2_k127_2872964_8 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 334.0
TLS2_k127_2872964_9 3-demethylubiquinone-9 3-methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 287.0
TLS2_k127_2875649_0 von Willebrand factor, type A K11912 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001539 262.0
TLS2_k127_2875649_1 response regulator K07776 - - 0.0000000000000000000000000000000000000000001166 160.0
TLS2_k127_2875649_2 - - - - 0.0000000000000000000000000000000000001737 147.0
TLS2_k127_2875649_3 Phage shock protein A K03615,K03969,K09749,K21471 - - 0.00000000000000000000000002385 115.0
TLS2_k127_2888380_0 modulator of DNA gyrase K03568 - - 3.718e-206 651.0
TLS2_k127_2888380_1 TIGRFAM ribonuclease, Rne Rng family K08301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 589.0
TLS2_k127_2888380_10 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000001906 164.0
TLS2_k127_2888380_11 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000000003532 148.0
TLS2_k127_2888380_12 Protein of unknown function (DUF615) K09889 - - 0.000000000000000000004836 101.0
TLS2_k127_2888380_13 Trm112p-like protein - - - 0.000000000000000005032 87.0
TLS2_k127_2888380_14 modulator of DNA gyrase K03592 - - 0.0000003329 55.0
TLS2_k127_2888380_15 MerC mercury resistance protein - - - 0.0001665 45.0
TLS2_k127_2888380_2 TIGRFAM TIGR02099 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 415.0
TLS2_k127_2888380_3 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 378.0
TLS2_k127_2888380_4 Type II secretory pathway component ExeA K02450,K12283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 317.0
TLS2_k127_2888380_5 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 292.0
TLS2_k127_2888380_6 DNA polymerase III, delta subunit K02340 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 296.0
TLS2_k127_2888380_7 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000008828 231.0
TLS2_k127_2888380_8 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000000000000000002065 235.0
TLS2_k127_2888380_9 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000008634 184.0
TLS2_k127_2910404_0 dienelactone hydrolase - - - 4.093e-257 820.0
TLS2_k127_2910404_1 COG2303 Choline dehydrogenase and related flavoproteins - - - 7.542e-243 761.0
TLS2_k127_2910404_10 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000177 179.0
TLS2_k127_2910404_11 nitric oxide dioxygenase activity - - - 0.0000000000000000000000000000003611 126.0
TLS2_k127_2910404_12 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000002405 101.0
TLS2_k127_2910404_13 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000003831 84.0
TLS2_k127_2910404_14 Thioredoxin-like - - - 0.000000000000735 78.0
TLS2_k127_2910404_15 Cytochrome C' - - - 0.000000000007915 72.0
TLS2_k127_2910404_2 transporter K08369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 605.0
TLS2_k127_2910404_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 500.0
TLS2_k127_2910404_4 Trehalose utilisation K09992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 303.0
TLS2_k127_2910404_5 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) K01126,K10716 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000005343 276.0
TLS2_k127_2910404_6 Copper type II ascorbate-dependent monooxygenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005669 263.0
TLS2_k127_2910404_7 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000001419 202.0
TLS2_k127_2910404_8 - - - - 0.00000000000000000000000000000000000000000000000000000001986 215.0
TLS2_k127_2910404_9 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000003964 191.0
TLS2_k127_2916608_0 thiolester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 617.0
TLS2_k127_2916608_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000001084 134.0
TLS2_k127_2932813_0 DNA topological change K03168 - 5.99.1.2 8.211e-236 754.0
TLS2_k127_2932813_1 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 423.0
TLS2_k127_2932813_2 Oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 370.0
TLS2_k127_2932813_3 Ankyrin repeat - - - 0.0000000000000000000000000000009115 130.0
TLS2_k127_2940314_0 TonB-dependent receptor K02014 - - 0.0 1132.0
TLS2_k127_2940314_1 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.0 1054.0
TLS2_k127_2940314_10 COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 588.0
TLS2_k127_2940314_11 peptidase M48, Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 505.0
TLS2_k127_2940314_12 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 477.0
TLS2_k127_2940314_13 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family K03317 GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 467.0
TLS2_k127_2940314_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 365.0
TLS2_k127_2940314_15 oxidase, subunit K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 346.0
TLS2_k127_2940314_16 Cytochrome c oxidase subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000001244 219.0
TLS2_k127_2940314_17 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000008916 208.0
TLS2_k127_2940314_18 enzyme of the cupin superfamily K06995 - - 0.0000000000000000000000000000000000000000000000000000002154 199.0
TLS2_k127_2940314_19 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000001463 201.0
TLS2_k127_2940314_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 6.693e-310 959.0
TLS2_k127_2940314_20 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000007714 163.0
TLS2_k127_2940314_21 oxidase, subunit IV - - - 0.000000000000000000000000000000000004443 139.0
TLS2_k127_2940314_22 Sigma-70, region 4 - - - 0.00000000000000000000000006705 113.0
TLS2_k127_2940314_3 Domain of unknown function (DUF5117) - - - 5.981e-280 886.0
TLS2_k127_2940314_4 Oligopeptidase F K08602 - - 7.807e-250 788.0
TLS2_k127_2940314_5 Amidohydrolase family - - - 2.909e-248 779.0
TLS2_k127_2940314_6 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit K00316 - 1.5.99.6 1.312e-244 772.0
TLS2_k127_2940314_7 Sulfotransferase domain - - - 1.574e-225 709.0
TLS2_k127_2940314_8 Na+/H+ antiporter family - - - 1.685e-200 633.0
TLS2_k127_2940314_9 Tryptophan halogenase K14266 - 1.14.19.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 602.0
TLS2_k127_2942529_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1297.0
TLS2_k127_2942529_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.995e-211 664.0
TLS2_k127_2942529_10 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.00000000000000000000000000000000002291 139.0
TLS2_k127_2942529_11 RDD family - - - 0.000000000000000000000000000004142 130.0
TLS2_k127_2942529_2 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 593.0
TLS2_k127_2942529_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 524.0
TLS2_k127_2942529_4 PFAM transglutaminase domain protein K22452 - 2.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 467.0
TLS2_k127_2942529_5 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 362.0
TLS2_k127_2942529_6 Permease YjgP YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006915 283.0
TLS2_k127_2942529_7 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001427 248.0
TLS2_k127_2942529_8 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002257 237.0
TLS2_k127_2942529_9 Permease YjgP YjgQ K11720 - - 0.000000000000000000000000000000000000000000000000000000004193 213.0
TLS2_k127_2959555_0 RNase_H superfamily - - - 0.0 1040.0
TLS2_k127_2959555_1 heme binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 314.0
TLS2_k127_2959555_2 Alanine acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000213 254.0
TLS2_k127_2959555_3 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000001918 231.0
TLS2_k127_2959555_4 Acetyltransferase (GNAT) domain K00663 - 2.3.1.82 0.00000000000000000000000000000000000000000000000000000000001495 211.0
TLS2_k127_2959555_5 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000364 111.0
TLS2_k127_2959555_6 belongs to the sigma-70 factor family, ECF subfamily K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000001925 92.0
TLS2_k127_2959555_7 - - - - 0.0000000000000006512 84.0
TLS2_k127_2959555_8 HEAT repeats - - - 0.000000000000002684 86.0
TLS2_k127_2959555_9 methyltransferase activity - - - 0.0000000006215 63.0
TLS2_k127_300989_0 Patched family K07003 - - 1.227e-254 806.0
TLS2_k127_300989_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007642 576.0
TLS2_k127_300989_10 iron-regulated membrane protein - - - 0.0008789 47.0
TLS2_k127_300989_2 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 553.0
TLS2_k127_300989_3 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 539.0
TLS2_k127_300989_4 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000866 271.0
TLS2_k127_300989_5 TonB-dependent siderophore receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000004204 213.0
TLS2_k127_300989_6 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000008903 168.0
TLS2_k127_300989_7 PFAM glutathione-dependent formaldehyde-activating GFA - - - 0.0000000000000000000000000000000000003485 144.0
TLS2_k127_300989_8 TonB-dependent siderophore receptor K02014 - - 0.0000000000000000002056 93.0
TLS2_k127_300989_9 bis(5'-adenosyl)-triphosphatase activity K02503 - - 0.0000000000000000144 87.0
TLS2_k127_3058401_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 435.0
TLS2_k127_3058401_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 312.0
TLS2_k127_3058401_2 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003055 267.0
TLS2_k127_3058401_3 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000002579 186.0
TLS2_k127_3058401_4 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000005931 160.0
TLS2_k127_3058401_5 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000006865 149.0
TLS2_k127_3058401_6 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000002396 123.0
TLS2_k127_3058401_7 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000001341 68.0
TLS2_k127_3060403_0 ABC transporter - - - 6.848e-283 880.0
TLS2_k127_3060403_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.437e-204 643.0
TLS2_k127_3060403_10 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 0.00000000000000000000000000000000000001089 145.0
TLS2_k127_3060403_11 - - - - 0.00000000000000000000000000000000001363 145.0
TLS2_k127_3060403_12 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000009547 130.0
TLS2_k127_3060403_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 486.0
TLS2_k127_3060403_3 PFAM histone deacetylase superfamily K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 418.0
TLS2_k127_3060403_4 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 373.0
TLS2_k127_3060403_5 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004965 274.0
TLS2_k127_3060403_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000000000006668 226.0
TLS2_k127_3060403_7 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000001545 227.0
TLS2_k127_3060403_8 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000002669 207.0
TLS2_k127_3060403_9 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 0.000000000000000000000000000000000000000001609 162.0
TLS2_k127_3070535_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.0 1097.0
TLS2_k127_3070535_1 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 0.0 1013.0
TLS2_k127_3070535_10 glycosyl hydrolase of K09955 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 597.0
TLS2_k127_3070535_11 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005736 573.0
TLS2_k127_3070535_12 ABC-type sugar transport system periplasmic component K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 557.0
TLS2_k127_3070535_13 Xylulose kinase K00854 - 2.7.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 529.0
TLS2_k127_3070535_14 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 477.0
TLS2_k127_3070535_15 Converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 462.0
TLS2_k127_3070535_16 GguC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 444.0
TLS2_k127_3070535_17 Hypothetical methyltransferase K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 403.0
TLS2_k127_3070535_18 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 409.0
TLS2_k127_3070535_19 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 423.0
TLS2_k127_3070535_2 symporter activity K03307 - - 2.921e-277 862.0
TLS2_k127_3070535_20 Belongs to the glycosyl hydrolase 43 family K06113 - 3.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 400.0
TLS2_k127_3070535_21 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 383.0
TLS2_k127_3070535_22 Cupin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 379.0
TLS2_k127_3070535_23 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002673 372.0
TLS2_k127_3070535_24 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 356.0
TLS2_k127_3070535_25 gntR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 345.0
TLS2_k127_3070535_26 TonB-dependent Receptor Plug Domain - - - 0.0000000000000000000000000000000000000000000000000000000000003788 215.0
TLS2_k127_3070535_27 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000009177 201.0
TLS2_k127_3070535_28 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000532 177.0
TLS2_k127_3070535_29 low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000002227 171.0
TLS2_k127_3070535_3 MacB-like periplasmic core domain - - - 3.572e-246 786.0
TLS2_k127_3070535_30 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000002336 163.0
TLS2_k127_3070535_31 efflux transmembrane transporter activity - - - 0.000000001566 64.0
TLS2_k127_3070535_4 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 3.704e-246 769.0
TLS2_k127_3070535_5 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 1.394e-222 700.0
TLS2_k127_3070535_6 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 2.332e-218 684.0
TLS2_k127_3070535_7 Dehydrogenase K13877 - 1.2.1.26 5.045e-205 650.0
TLS2_k127_3070535_8 MacB-like periplasmic core domain - - - 3.157e-194 634.0
TLS2_k127_3070535_9 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 623.0
TLS2_k127_3085697_0 Carboxypeptidase regulatory-like domain - - - 0.0 1162.0
TLS2_k127_3085697_1 dihydroorotase - - - 7.916e-252 783.0
TLS2_k127_3085697_10 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 371.0
TLS2_k127_3085697_11 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 292.0
TLS2_k127_3085697_12 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000000000000000000000000000002699 225.0
TLS2_k127_3085697_13 Acid phosphatase - - - 0.0000000000000000000000000000000000000000000000915 181.0
TLS2_k127_3085697_14 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000000007955 133.0
TLS2_k127_3085697_2 uracil, thiamine, allantoin K03457 - - 8.512e-233 729.0
TLS2_k127_3085697_3 Dihydroorotate dehydrogenase - - - 3.575e-225 704.0
TLS2_k127_3085697_4 TonB-dependent Receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 591.0
TLS2_k127_3085697_5 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K17722 - 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006187 555.0
TLS2_k127_3085697_6 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009032,GO:0009116,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0033554,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072527,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 484.0
TLS2_k127_3085697_7 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 479.0
TLS2_k127_3085697_8 nucleoside K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 441.0
TLS2_k127_3085697_9 Inosine-uridine preferring nucleoside hydrolase K01239,K01250 - 3.2.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 413.0
TLS2_k127_3103810_0 TonB dependent receptor - - - 0.0 1075.0
TLS2_k127_3103810_1 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 586.0
TLS2_k127_3103810_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000009176 147.0
TLS2_k127_3103810_11 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000001046 120.0
TLS2_k127_3103810_12 acetyltransferase - - - 0.000000000000000000000000005975 116.0
TLS2_k127_3103810_13 Phosphoglycerate mutase family - - - 0.000000000000000000000001344 111.0
TLS2_k127_3103810_2 peptidase, M16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 435.0
TLS2_k127_3103810_3 Belongs to the prokaryotic GSH synthase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 418.0
TLS2_k127_3103810_4 DUF1704 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 332.0
TLS2_k127_3103810_5 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006917 264.0
TLS2_k127_3103810_6 Serine phosphatase RsbU, regulator of sigma subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000372 233.0
TLS2_k127_3103810_7 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000008101 205.0
TLS2_k127_3103810_8 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000002525 169.0
TLS2_k127_3103810_9 Protein of unknown function (DUF3187) - - - 0.000000000000000000000000000000000000001244 160.0
TLS2_k127_3116969_0 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 591.0
TLS2_k127_3116969_1 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 497.0
TLS2_k127_3116969_10 Prokaryotic N-terminal methylation motif K10924 - - 0.00000001036 64.0
TLS2_k127_3116969_11 - - - - 0.000001603 57.0
TLS2_k127_3116969_2 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 406.0
TLS2_k127_3116969_3 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 384.0
TLS2_k127_3116969_4 Histidine-specific methyltransferase, SAM-dependent K18911 - 2.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 351.0
TLS2_k127_3116969_5 PFAM AsmA family protein K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006882 357.0
TLS2_k127_3116969_6 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000009269 162.0
TLS2_k127_3116969_7 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000000000002615 145.0
TLS2_k127_3116969_8 Putative adhesin - - - 0.000000000000000000000000004481 123.0
TLS2_k127_3116969_9 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000002838 93.0
TLS2_k127_3125405_0 ATPases involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 348.0
TLS2_k127_3125405_1 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009428 323.0
TLS2_k127_3125405_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 319.0
TLS2_k127_3125405_3 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000001553 175.0
TLS2_k127_3125405_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000001616 128.0
TLS2_k127_3125405_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000002711 78.0
TLS2_k127_3125405_6 ATP synthase K02116 - - 0.0000000003052 68.0
TLS2_k127_3184818_0 Pilus formation protein N terminal region K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 498.0
TLS2_k127_3184818_1 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 428.0
TLS2_k127_3184818_2 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.0000000000000000000000000000000000000000000000000000000000001223 222.0
TLS2_k127_3196744_0 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005431 480.0
TLS2_k127_3196744_1 COG0471 Di- and tricarboxylate transporters - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005205 486.0
TLS2_k127_3196744_2 Peptidase family M20/M25/M40 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 396.0
TLS2_k127_3196744_3 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 358.0
TLS2_k127_3196744_4 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000002615 257.0
TLS2_k127_3196744_5 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000001177 193.0
TLS2_k127_3196744_6 Protein of unknown function (DUF1318) - - - 0.000000000000000000000000000000000000000000000006465 179.0
TLS2_k127_3245534_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009506 267.0
TLS2_k127_3245534_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07662 - - 0.00000000000000000000000000000000000000000000000000000000000006314 224.0
TLS2_k127_3245534_2 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000118 211.0
TLS2_k127_3245534_3 - - - - 0.000000000583 71.0
TLS2_k127_3245534_4 LTXXQ motif family protein - - - 0.0002601 51.0
TLS2_k127_3262112_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 566.0
TLS2_k127_3262112_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004669 529.0
TLS2_k127_3262112_2 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 425.0
TLS2_k127_3262112_3 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 294.0
TLS2_k127_3262112_4 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007537 271.0
TLS2_k127_3262112_5 PFAM MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005358 266.0
TLS2_k127_3262112_6 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000163 255.0
TLS2_k127_3262112_7 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.00000000000000000000000000000000000000000001924 169.0
TLS2_k127_3262112_8 COG0848 Biopolymer transport protein K03559 - - 0.00000000000000000000000000000000000002346 151.0
TLS2_k127_3276520_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1131.0
TLS2_k127_3276520_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 1.232e-221 698.0
TLS2_k127_3276520_10 type I secretion outer membrane protein, TolC K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 305.0
TLS2_k127_3276520_11 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000005553 194.0
TLS2_k127_3276520_12 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852,K00856,K10710,K22026 - 2.7.1.15,2.7.1.20,2.7.1.213,2.7.1.218,2.7.1.73 0.0000000000000000000000000000000000000000000794 171.0
TLS2_k127_3276520_13 PIN domain - - - 0.000000000000000000000000000000000000000007998 158.0
TLS2_k127_3276520_14 SMART Rhodanese domain protein - - - 0.00000000000000000000000001893 111.0
TLS2_k127_3276520_15 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000000000000000004061 102.0
TLS2_k127_3276520_2 Sugar phosphate permease K02445 - - 4.32e-196 620.0
TLS2_k127_3276520_3 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008047 533.0
TLS2_k127_3276520_4 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 529.0
TLS2_k127_3276520_5 3-phytase (Myo-inositol-hexaphosphate 3-phosphohydrolase) K01083 - 3.1.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 509.0
TLS2_k127_3276520_6 3-Deoxy-D-manno-octulosonic-acid transferase K02527 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 406.0
TLS2_k127_3276520_7 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 399.0
TLS2_k127_3276520_8 acid phosphatase K14379 - 3.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 376.0
TLS2_k127_3276520_9 COG0209 Ribonucleotide reductase, alpha subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 304.0
TLS2_k127_3345591_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 603.0
TLS2_k127_3345591_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 302.0
TLS2_k127_3345591_2 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000004162 276.0
TLS2_k127_3345591_3 enzyme of heme biosynthesis K02498 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000636 272.0
TLS2_k127_3345591_4 Response regulator of the LytR AlgR family K08083 - - 0.00000000000000000000000000000000000000000000000000000000000000000002843 243.0
TLS2_k127_3345591_5 involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000001375 222.0
TLS2_k127_3345591_6 Protein of unknown function, DUF484 K09921 - - 0.000000000000000000000000000000000000000000000001458 182.0
TLS2_k127_3345591_7 PFAM Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.00000000000000000000000000000006567 138.0
TLS2_k127_3345591_8 HemX, putative uroporphyrinogen-III C-methyltransferase K02496 - 2.1.1.107 0.00000000000000000000000000000006939 141.0
TLS2_k127_3345591_9 Domain of unknown function (DUF4124) - - - 0.0000000007439 66.0
TLS2_k127_3348906_0 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000572 384.0
TLS2_k127_3348906_1 FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 304.0
TLS2_k127_3348906_2 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000001566 203.0
TLS2_k127_3348906_3 Cytochrome b5-like Heme/Steroid binding domain - - - 0.00000000000000000000000000000000000008012 145.0
TLS2_k127_3348906_4 Universal stress protein - - - 0.0000000000000004524 89.0
TLS2_k127_3383198_0 glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 567.0
TLS2_k127_3383198_1 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 344.0
TLS2_k127_3383198_10 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000001568 197.0
TLS2_k127_3383198_11 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000000000000000007463 173.0
TLS2_k127_3383198_12 Arc-like DNA binding domain K21495 - - 0.0000000000000000000000000000001572 126.0
TLS2_k127_3383198_13 Belongs to the 'phage' integrase family - - - 0.00000000000007092 79.0
TLS2_k127_3383198_14 Metallophosphoesterase - - - 0.0000000002066 69.0
TLS2_k127_3383198_15 Protein of unknown function DUF86 - - - 0.0000000003092 62.0
TLS2_k127_3383198_16 Nucleotidyltransferase domain K07075 - - 0.00000001201 57.0
TLS2_k127_3383198_17 FAD binding domain - - - 0.0000001772 54.0
TLS2_k127_3383198_18 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00005111 55.0
TLS2_k127_3383198_19 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00008936 55.0
TLS2_k127_3383198_2 Pirin K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 331.0
TLS2_k127_3383198_20 - - - - 0.0006163 49.0
TLS2_k127_3383198_21 amine dehydrogenase activity - - - 0.0006811 46.0
TLS2_k127_3383198_3 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 309.0
TLS2_k127_3383198_4 Domain of unknown function (DUF4172) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001073 253.0
TLS2_k127_3383198_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.000000000000000000000000000000000000000000000000000000000000000005407 227.0
TLS2_k127_3383198_6 protocatechuate 3,4-dioxygenase K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000001213 230.0
TLS2_k127_3383198_7 Response regulator of the LytR AlgR family - - - 0.000000000000000000000000000000000000000000000000000004216 202.0
TLS2_k127_3383198_8 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000002729 211.0
TLS2_k127_3383198_9 signal transduction protein with a C-terminal ATPase domain K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000003455 196.0
TLS2_k127_3420879_0 receptor K16091 - - 2.751e-220 710.0
TLS2_k127_3420879_1 cellulose binding - - - 5.774e-214 671.0
TLS2_k127_3420879_10 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000008481 212.0
TLS2_k127_3420879_11 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000001056 156.0
TLS2_k127_3420879_12 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000004846 154.0
TLS2_k127_3420879_14 NmrA-like family - - - 0.0000000000000000000000002934 123.0
TLS2_k127_3420879_15 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000005135 122.0
TLS2_k127_3420879_16 BFD-like [2Fe-2S] binding domain - - - 0.000000000002633 70.0
TLS2_k127_3420879_17 Methionine biosynthesis protein MetW - - - 0.000000000003619 73.0
TLS2_k127_3420879_18 PFAM Uncharacterised protein family (UPF0104) K07027 - - 0.00006822 54.0
TLS2_k127_3420879_2 response regulator receiver K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 588.0
TLS2_k127_3420879_3 acetoacetate metabolism regulatory protein AtoC K07714 K07715 GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 514.0
TLS2_k127_3420879_4 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006923 409.0
TLS2_k127_3420879_5 involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 393.0
TLS2_k127_3420879_6 Short-chain dehydrogenase reductase sdr K00046 - 1.1.1.69 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 317.0
TLS2_k127_3420879_7 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006774 296.0
TLS2_k127_3420879_8 Iron-storage protein K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000001666 235.0
TLS2_k127_3420879_9 cAMP biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000001032 233.0
TLS2_k127_3435637_0 COG0471 Di- and tricarboxylate transporters - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005639 413.0
TLS2_k127_3435637_1 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 304.0
TLS2_k127_3435637_2 Methylenetetrahydrofolate reductase - - - 0.0000000000000000000000000000000000000000000005724 177.0
TLS2_k127_3438387_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008011 352.0
TLS2_k127_3438387_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 302.0
TLS2_k127_3438387_2 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000001008 205.0
TLS2_k127_3438387_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000003324 142.0
TLS2_k127_3438387_4 - - - - 0.00000000000000000000000009719 121.0
TLS2_k127_3438387_5 Cytochrome c - - - 0.0000000000008858 80.0
TLS2_k127_3444210_0 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 610.0
TLS2_k127_3444210_1 saccharopine dehydrogenase activity K00290 - 1.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 415.0
TLS2_k127_3515333_0 Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006502 551.0
TLS2_k127_3515333_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001156 252.0
TLS2_k127_3515333_2 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000000000002297 208.0
TLS2_k127_3515333_3 at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) K04752 - - 0.00000000000000000000000000000000000000000000000005702 194.0
TLS2_k127_3515333_4 cytochrome - - - 0.0000000000000000000000001229 112.0
TLS2_k127_3515333_5 Membrane fusogenic activity K09806 - - 0.00000000000000000001759 98.0
TLS2_k127_3515333_6 Ammonium transporter K03320 - - 0.0000000000000000007464 88.0
TLS2_k127_3537552_0 TonB dependent receptor - - - 1.098e-300 941.0
TLS2_k127_3537552_1 COG0457 FOG TPR repeat - - - 3.636e-241 763.0
TLS2_k127_3537552_10 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 491.0
TLS2_k127_3537552_11 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 468.0
TLS2_k127_3537552_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 462.0
TLS2_k127_3537552_13 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 417.0
TLS2_k127_3537552_14 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 413.0
TLS2_k127_3537552_15 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 407.0
TLS2_k127_3537552_16 Tetratricopeptide repeat K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 372.0
TLS2_k127_3537552_17 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009774 284.0
TLS2_k127_3537552_18 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001586 284.0
TLS2_k127_3537552_19 Von willebrand factor, type a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000403 287.0
TLS2_k127_3537552_2 von Willebrand factor type A domain - - - 2.727e-232 783.0
TLS2_k127_3537552_20 Domain of Unknown Function (DUF1206) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004666 271.0
TLS2_k127_3537552_21 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001407 266.0
TLS2_k127_3537552_22 xylanase chitin deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007159 253.0
TLS2_k127_3537552_23 PFAM O-methyltransferase, family 3 K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000008697 234.0
TLS2_k127_3537552_24 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000000000000000000000000001551 241.0
TLS2_k127_3537552_25 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000000000000000000000000000000000000000000000000003047 227.0
TLS2_k127_3537552_26 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000002203 215.0
TLS2_k127_3537552_27 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000007093 176.0
TLS2_k127_3537552_28 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000002363 173.0
TLS2_k127_3537552_29 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K03796 - - 0.000000000000000000000000000000000000000000001458 175.0
TLS2_k127_3537552_3 Putative glucoamylase K01183 - 3.2.1.14 1.287e-223 715.0
TLS2_k127_3537552_30 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000005106 161.0
TLS2_k127_3537552_31 COG1413 FOG HEAT repeat - - - 0.0000000000000000000000000000000001027 147.0
TLS2_k127_3537552_32 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000000000000000000000000001059 131.0
TLS2_k127_3537552_33 - - - - 0.00000000000000000000000000000001344 144.0
TLS2_k127_3537552_34 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000004862 117.0
TLS2_k127_3537552_36 - - - - 0.00000000000000000000001296 109.0
TLS2_k127_3537552_37 - - - - 0.000000000001308 78.0
TLS2_k127_3537552_38 Alpha/beta hydrolase family - - - 0.000000000008344 67.0
TLS2_k127_3537552_39 Domain of unknown function (DUF4412) - - - 0.0000002647 61.0
TLS2_k127_3537552_4 Belongs to the cysteine synthase cystathionine beta- synthase family - - - 7.462e-217 683.0
TLS2_k127_3537552_40 Transglutaminase-like superfamily - - - 0.0000003483 64.0
TLS2_k127_3537552_41 - - - - 0.0000008253 62.0
TLS2_k127_3537552_42 Helix-turn-helix XRE-family like proteins - - - 0.00002399 50.0
TLS2_k127_3537552_5 carboxylic ester hydrolase activity - - - 2.092e-213 697.0
TLS2_k127_3537552_6 TrkA-N domain - - - 3.033e-212 674.0
TLS2_k127_3537552_7 oxidoreductase K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 564.0
TLS2_k127_3537552_8 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009013 545.0
TLS2_k127_3537552_9 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 519.0
TLS2_k127_360866_0 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 511.0
TLS2_k127_360866_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 457.0
TLS2_k127_360866_2 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008446 401.0
TLS2_k127_360866_3 Haem-NO-binding - - - 0.00000000000000000000000000000000000000000000000000000009785 204.0
TLS2_k127_360866_4 MASE1 - - - 0.0000000000000000000000000000000000000000000000000000575 205.0
TLS2_k127_360866_5 Low affinity iron permease - - - 0.00000000000000000000000000000000000000000000000003984 181.0
TLS2_k127_360866_7 Diguanylate cyclase - - - 0.00000000000000000000000001075 125.0
TLS2_k127_3671422_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 555.0
TLS2_k127_3671422_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008272 496.0
TLS2_k127_3671422_2 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006819 339.0
TLS2_k127_3671422_3 cAMP phosphodiesterases class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002744 278.0
TLS2_k127_3671422_4 phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002164 279.0
TLS2_k127_3671422_5 transport system permease component - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000967 149.0
TLS2_k127_3671422_6 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000003172 136.0
TLS2_k127_3687292_0 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 6.046e-297 929.0
TLS2_k127_3687292_1 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 397.0
TLS2_k127_3687292_10 PRC-barrel domain - - - 0.00000000000000003286 88.0
TLS2_k127_3687292_11 Polymer-forming cytoskeletal - - - 0.00000000000009095 77.0
TLS2_k127_3687292_12 Diguanylate cyclase - - - 0.0000000000008787 72.0
TLS2_k127_3687292_13 Chromosome partitioning protein ParA - - - 0.0000000002333 67.0
TLS2_k127_3687292_14 - - - - 0.0000000291 61.0
TLS2_k127_3687292_15 cheY-homologous receiver domain - - - 0.0000009684 56.0
TLS2_k127_3687292_16 Entericidin EcnA/B family - - - 0.00004682 47.0
TLS2_k127_3687292_2 ZIP Zinc transporter K07238 GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015086,GO:0015087,GO:0015093,GO:0015318,GO:0015684,GO:0015691,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0034755,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071421,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903874 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 361.0
TLS2_k127_3687292_3 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001509 265.0
TLS2_k127_3687292_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002355 256.0
TLS2_k127_3687292_5 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000001733 201.0
TLS2_k127_3687292_6 Belongs to the UPF0337 (CsbD) family - - - 0.0000000000000000000007701 96.0
TLS2_k127_3687292_7 Polymer-forming cytoskeletal - - - 0.0000000000000000000008584 102.0
TLS2_k127_3687292_8 Proteolipid membrane potential modulator - - - 0.000000000000000000002595 95.0
TLS2_k127_3687292_9 UPF0391 membrane protein - - - 0.000000000000000004928 85.0
TLS2_k127_369213_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 5.815e-266 847.0
TLS2_k127_369213_1 COG0471 Di- and tricarboxylate transporters - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 606.0
TLS2_k127_369213_10 Belongs to the TrpC family K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000008015 169.0
TLS2_k127_369213_11 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000004941 125.0
TLS2_k127_369213_12 Putative prokaryotic signal transducing protein - - - 0.00000000000000000006367 93.0
TLS2_k127_369213_13 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0006375 52.0
TLS2_k127_369213_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 448.0
TLS2_k127_369213_3 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 389.0
TLS2_k127_369213_4 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001922 274.0
TLS2_k127_369213_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000003489 264.0
TLS2_k127_369213_6 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000009181 245.0
TLS2_k127_369213_7 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000000004971 202.0
TLS2_k127_369213_8 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000002763 196.0
TLS2_k127_369213_9 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018 - 1.1.1.29 0.00000000000000000000000000000000000000000000000007637 183.0
TLS2_k127_3699109_0 COG3209 Rhs family protein - - - 0.0 1253.0
TLS2_k127_3699109_1 FtsX-like permease family K02004 - - 4.028e-200 651.0
TLS2_k127_3699109_2 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000013 246.0
TLS2_k127_3699109_3 COG1943 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000003204 221.0
TLS2_k127_3699109_4 Belongs to the Nudix hydrolase family K01518 - 3.6.1.17 0.0000000000000000000000000000000000000000000000005467 178.0
TLS2_k127_3699109_5 - - - - 0.00003012 50.0
TLS2_k127_371391_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 6.147e-232 731.0
TLS2_k127_371391_1 Protein tyrosine kinase - - - 5.624e-218 703.0
TLS2_k127_371391_10 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000007199 236.0
TLS2_k127_371391_11 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000000000000000000000000000000000000000000000000000001836 223.0
TLS2_k127_371391_12 Belongs to the DnaA family. HdA subfamily K10763 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000001315 186.0
TLS2_k127_371391_13 PFAM CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.00000000000000000000000000000000000000000000005399 181.0
TLS2_k127_371391_14 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000002507 153.0
TLS2_k127_371391_15 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.00000000000000000000000000000000000005034 143.0
TLS2_k127_371391_16 protein conserved in bacteria K09938 - - 0.000000000000000000000000000000000001322 154.0
TLS2_k127_371391_17 arsenate reductase K00537 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 0.0000000000000000000000000000002523 127.0
TLS2_k127_371391_18 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000005533 116.0
TLS2_k127_371391_19 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000354 97.0
TLS2_k127_371391_2 PFAM Type II secretion system protein E - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007713 527.0
TLS2_k127_371391_3 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 445.0
TLS2_k127_371391_4 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 439.0
TLS2_k127_371391_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 439.0
TLS2_k127_371391_6 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 347.0
TLS2_k127_371391_7 Belongs to the WrbA family K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006862 271.0
TLS2_k127_371391_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009085 273.0
TLS2_k127_371391_9 Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000003361 263.0
TLS2_k127_3723184_0 Phosphoenolpyruvate phosphomutase - - - 3.794e-199 628.0
TLS2_k127_3723184_1 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004411,GO:0005488,GO:0005506,GO:0005575,GO:0006082,GO:0006355,GO:0006520,GO:0006558,GO:0006559,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0019219,GO:0019222,GO:0019439,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051213,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 607.0
TLS2_k127_3723184_2 Transcriptional regulator, XRE family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 472.0
TLS2_k127_3723184_3 Fumarylacetoacetate (FAA) hydrolase K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 447.0
TLS2_k127_3723184_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K10617 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004489 273.0
TLS2_k127_3723184_5 at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) K04752 - - 0.000000000000000000000000000000000000000000000000000007031 191.0
TLS2_k127_3723184_6 Protein involved in outer membrane biogenesis - - - 0.000000000000000000000000000000000000000000004136 177.0
TLS2_k127_3723184_7 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000002323 126.0
TLS2_k127_3733107_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 6.359e-246 778.0
TLS2_k127_3733107_1 TIGRFAM penicillin-binding protein, 1A K05366 - 2.4.1.129,3.4.16.4 1.136e-220 713.0
TLS2_k127_3733107_10 PFAM YicC-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005626 272.0
TLS2_k127_3733107_11 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000004226 231.0
TLS2_k127_3733107_12 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000002899 209.0
TLS2_k127_3733107_13 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000000000000000000001942 205.0
TLS2_k127_3733107_14 Pilus assembly protein PilO K02664 - - 0.000000000000000000000000000000000000000000000000000001242 199.0
TLS2_k127_3733107_15 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000003206 192.0
TLS2_k127_3733107_16 endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000001857 175.0
TLS2_k127_3733107_17 PFAM Fimbrial assembly K02663 - - 0.000000000000000000000000000000000000000000003109 170.0
TLS2_k127_3733107_18 pilus assembly protein PilP K02665 - - 0.0000000000000000000000000000000000000000002183 165.0
TLS2_k127_3733107_19 mRNA catabolic process - - - 0.000000000000000000000000000000000000000007287 167.0
TLS2_k127_3733107_2 type IV pilus secretin PilQ K02666 - - 6.365e-201 649.0
TLS2_k127_3733107_20 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000000000009811 128.0
TLS2_k127_3733107_21 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000003931 101.0
TLS2_k127_3733107_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.521e-195 621.0
TLS2_k127_3733107_4 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 486.0
TLS2_k127_3733107_5 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 467.0
TLS2_k127_3733107_6 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 407.0
TLS2_k127_3733107_7 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 389.0
TLS2_k127_3733107_8 Pilus assembly protein K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 374.0
TLS2_k127_3733107_9 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 353.0
TLS2_k127_3734032_0 phosphomannomutase K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 577.0
TLS2_k127_3734032_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000003175 203.0
TLS2_k127_3744765_0 Carboxypeptidase regulatory-like domain - - - 1.999e-247 781.0
TLS2_k127_3744765_1 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005503 560.0
TLS2_k127_3744765_2 FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 456.0
TLS2_k127_3744765_3 cytochrome C family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 362.0
TLS2_k127_3744765_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000009778 138.0
TLS2_k127_3744765_5 Cytochrome b5-like Heme/Steroid binding domain - - - 0.0000000000000000000000000000000009349 136.0
TLS2_k127_3744765_6 Cytochrome c - - - 0.0000000000000000000000000000001206 136.0
TLS2_k127_3744765_7 MMPL family K07003 - - 0.0000000000000000000009324 97.0
TLS2_k127_3761105_0 PFAM Aldehyde oxidase xanthine dehydrogenase, molybdopterin binding K07303 - 1.3.99.16 2.575e-308 962.0
TLS2_k127_3761105_1 Glucoamylase and related glycosyl hydrolases - - - 5.091e-238 752.0
TLS2_k127_3761105_10 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000002163 241.0
TLS2_k127_3761105_11 Glucokinase K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000006009 220.0
TLS2_k127_3761105_12 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000007301 201.0
TLS2_k127_3761105_13 thiolester hydrolase activity K06889,K07000 - - 0.00000000000000000000000000000000000000000001671 168.0
TLS2_k127_3761105_14 Cupin domain - - - 0.00000000000000000000000000000000000000000007671 162.0
TLS2_k127_3761105_15 Putative stress-induced transcription regulator - - - 0.00000000000000000000000000000002171 134.0
TLS2_k127_3761105_16 methylated DNA-protein cysteine methyltransferase K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 - 0.00000000000000000000000000008736 120.0
TLS2_k127_3761105_17 lactoylglutathione lyase activity - - - 0.0000000000000000000000000004406 118.0
TLS2_k127_3761105_18 small protein containing a coiled-coil domain - - - 0.0000000000003057 72.0
TLS2_k127_3761105_2 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 4.004e-230 738.0
TLS2_k127_3761105_3 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 541.0
TLS2_k127_3761105_4 Domain of unknown function (DUF697) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 480.0
TLS2_k127_3761105_5 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 GO:0003674,GO:0003824,GO:0003825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034637,GO:0035251,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 480.0
TLS2_k127_3761105_6 TIGRFAM phenazine biosynthesis protein PhzF family K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 392.0
TLS2_k127_3761105_7 50S ribosome-binding GTPase K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 362.0
TLS2_k127_3761105_8 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 323.0
TLS2_k127_3761105_9 Belongs to the UPF0176 family K07146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 305.0
TLS2_k127_3798536_0 DEAD DEAH box K03724 - - 0.0 1729.0
TLS2_k127_3798536_1 Hydrophobe Amphiphile Efflux-1 (HAE1) K03296,K18138,K18299 - - 0.0 1656.0
TLS2_k127_3798536_10 - - - - 5.588e-234 747.0
TLS2_k127_3798536_11 AbgT putative transporter family K12942 - - 5.14e-229 719.0
TLS2_k127_3798536_12 Transmembrane secretion effector - - - 4.797e-203 649.0
TLS2_k127_3798536_13 Cytosol aminopeptidase family, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 611.0
TLS2_k127_3798536_14 COG1473 Metal-dependent amidase aminoacylase carboxypeptidase K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 601.0
TLS2_k127_3798536_15 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 595.0
TLS2_k127_3798536_16 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009368 588.0
TLS2_k127_3798536_17 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 566.0
TLS2_k127_3798536_18 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 562.0
TLS2_k127_3798536_19 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008198 548.0
TLS2_k127_3798536_2 Glycosyl hydrolase family 65, N-terminal domain K15923 - 3.2.1.51 0.0 1276.0
TLS2_k127_3798536_20 Domain of unknown function (DUF3333) K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 522.0
TLS2_k127_3798536_21 formamidase K01455 - 3.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 516.0
TLS2_k127_3798536_22 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 502.0
TLS2_k127_3798536_23 Proline racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 491.0
TLS2_k127_3798536_24 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 489.0
TLS2_k127_3798536_25 COG0226 ABC-type phosphate transport system, periplasmic component K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 467.0
TLS2_k127_3798536_26 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 469.0
TLS2_k127_3798536_27 Belongs to the LDH2 MDH2 oxidoreductase family K13574,K13609 - 1.5.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009765 440.0
TLS2_k127_3798536_28 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008727 426.0
TLS2_k127_3798536_29 PFAM Na Picotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 433.0
TLS2_k127_3798536_3 Domain of unknown function (DUF3362) - - - 0.0 1197.0
TLS2_k127_3798536_30 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 413.0
TLS2_k127_3798536_31 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 402.0
TLS2_k127_3798536_32 PFAM LysR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 397.0
TLS2_k127_3798536_33 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006153 398.0
TLS2_k127_3798536_34 Capsule assembly protein Wzi - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 384.0
TLS2_k127_3798536_35 imidazolonepropionase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 353.0
TLS2_k127_3798536_36 PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 329.0
TLS2_k127_3798536_37 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004547 327.0
TLS2_k127_3798536_38 heptosyltransferase K02849 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 319.0
TLS2_k127_3798536_39 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 295.0
TLS2_k127_3798536_4 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0 1064.0
TLS2_k127_3798536_40 Putative neutral zinc metallopeptidase K06973 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 286.0
TLS2_k127_3798536_41 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001054 278.0
TLS2_k127_3798536_42 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002219 277.0
TLS2_k127_3798536_43 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000551 271.0
TLS2_k127_3798536_44 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002297 270.0
TLS2_k127_3798536_45 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000572 272.0
TLS2_k127_3798536_46 Rhodanese Homology Domain K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000007853 265.0
TLS2_k127_3798536_47 polysaccharide catabolic process K03478 - 3.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000006564 259.0
TLS2_k127_3798536_48 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009296 259.0
TLS2_k127_3798536_49 efflux protein, MATE family K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000053 261.0
TLS2_k127_3798536_5 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 9.895e-320 1002.0
TLS2_k127_3798536_50 Belongs to the UPF0502 family K09915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000272 245.0
TLS2_k127_3798536_51 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005413 243.0
TLS2_k127_3798536_52 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000005743 237.0
TLS2_k127_3798536_53 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000006733 218.0
TLS2_k127_3798536_54 phosphate regulon transcriptional regulatory protein PhoB K07657 GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000008023 211.0
TLS2_k127_3798536_55 Glycosyl hydrolase family 46 K01233 - 3.2.1.132 0.0000000000000000000000000000000000000000000000000000000004197 207.0
TLS2_k127_3798536_57 short chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000335 194.0
TLS2_k127_3798536_58 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000001757 200.0
TLS2_k127_3798536_59 - - - - 0.00000000000000000000000000000000000000000000000003655 184.0
TLS2_k127_3798536_6 peptidase S9B dipeptidylpeptidase IV domain protein - - - 4.607e-292 915.0
TLS2_k127_3798536_60 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000002574 183.0
TLS2_k127_3798536_61 Alkaline phosphatase homologues K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000001197 186.0
TLS2_k127_3798536_62 YCII-related domain - - - 0.0000000000000000000000000000000000000000005382 160.0
TLS2_k127_3798536_63 Predicted membrane protein (DUF2243) - - - 0.0000000000000000000000000000000000000000008362 164.0
TLS2_k127_3798536_64 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000004638 146.0
TLS2_k127_3798536_65 PRC-barrel domain - - - 0.00000000000000000000000000000000006938 136.0
TLS2_k127_3798536_66 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000001891 114.0
TLS2_k127_3798536_67 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000383 99.0
TLS2_k127_3798536_68 - - - - 0.0000000000000001093 88.0
TLS2_k127_3798536_69 MgtE intracellular N domain - - - 0.000000000000001458 87.0
TLS2_k127_3798536_7 X-Pro dipeptidyl-peptidase (S15 family) - - - 1.053e-273 855.0
TLS2_k127_3798536_71 His Kinase A (phosphoacceptor) domain - - - 0.00000000000436 72.0
TLS2_k127_3798536_72 Protein kinase domain K12132 - 2.7.11.1 0.0000000001603 74.0
TLS2_k127_3798536_73 Cyclase dehydrase - - - 0.0000000003735 64.0
TLS2_k127_3798536_74 - - - - 0.000000003803 64.0
TLS2_k127_3798536_75 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0000001382 55.0
TLS2_k127_3798536_76 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000001513 59.0
TLS2_k127_3798536_78 Putative peptidoglycan binding domain - - - 0.0005772 49.0
TLS2_k127_3798536_8 Bacterial protein of unknown function (DUF885) - - - 3.813e-243 767.0
TLS2_k127_3798536_9 ABC transporter K06147 - - 1.221e-242 764.0
TLS2_k127_3800897_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 556.0
TLS2_k127_3800897_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 547.0
TLS2_k127_3800897_10 Glutamyl-tRNA amidotransferase K09117 - - 0.00000000000000000000000000000000000000000001538 168.0
TLS2_k127_3800897_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000009613 165.0
TLS2_k127_3800897_12 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000000000000000000000000000000000001983 155.0
TLS2_k127_3800897_13 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.000000000000000000000000000000000000001954 154.0
TLS2_k127_3800897_14 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000005872 106.0
TLS2_k127_3800897_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 428.0
TLS2_k127_3800897_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 401.0
TLS2_k127_3800897_4 Belongs to the peptidase S1C family K04691,K04771,K04772 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 378.0
TLS2_k127_3800897_5 PFAM Lytic K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 373.0
TLS2_k127_3800897_6 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 332.0
TLS2_k127_3800897_7 KR domain K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 292.0
TLS2_k127_3800897_8 Putative aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 291.0
TLS2_k127_3800897_9 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000002301 257.0
TLS2_k127_3818526_0 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 287.0
TLS2_k127_3818526_1 Belongs to the UPF0178 family K09768 - - 0.000000000000000000000000000000000000000000000000000000000000009116 234.0
TLS2_k127_3818526_2 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000009983 206.0
TLS2_k127_3818526_3 Berberine and berberine like - - - 0.000000000000000000000000000000000001104 147.0
TLS2_k127_3818972_0 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 553.0
TLS2_k127_3818972_1 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 517.0
TLS2_k127_3818972_10 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000001167 175.0
TLS2_k127_3818972_11 - - - - 0.0000000000000000000000000000000000000000003535 181.0
TLS2_k127_3818972_12 Cyclase dehydrase - - - 0.000000000000000000000000000000000000000003453 160.0
TLS2_k127_3818972_13 Acetyltransferase, GNAT K06977 - - 0.0000000000000000000000000000000000000008119 153.0
TLS2_k127_3818972_14 Belongs to the UPF0125 (RnfH) family K09801 - - 0.00000000000000000000001961 103.0
TLS2_k127_3818972_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.000000000000000000114 94.0
TLS2_k127_3818972_2 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 520.0
TLS2_k127_3818972_3 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 486.0
TLS2_k127_3818972_4 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 460.0
TLS2_k127_3818972_5 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009214 380.0
TLS2_k127_3818972_6 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000007351 258.0
TLS2_k127_3818972_7 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000001455 239.0
TLS2_k127_3818972_8 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000001335 217.0
TLS2_k127_3818972_9 transcription elongation factor GreA GreB K06140 - - 0.00000000000000000000000000000000000000000000000000000001547 202.0
TLS2_k127_3835727_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 6.649e-227 721.0
TLS2_k127_3835727_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 476.0
TLS2_k127_3835727_10 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000002895 170.0
TLS2_k127_3835727_11 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000002115 167.0
TLS2_k127_3835727_12 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000001535 163.0
TLS2_k127_3835727_13 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000002059 158.0
TLS2_k127_3835727_14 - - - - 0.00000000000000000000000000000002969 133.0
TLS2_k127_3835727_15 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000005926 129.0
TLS2_k127_3835727_16 Methyltransferase domain - - - 0.000000000000000000000000000000416 133.0
TLS2_k127_3835727_17 MAPEG family - - - 0.0000000000000000000000001906 111.0
TLS2_k127_3835727_18 Domain of unknown function (DUF1705) - - - 0.000000000000000000000006445 119.0
TLS2_k127_3835727_19 Glycosyl transferase family 2 K07011 - - 0.000000000000000000001896 106.0
TLS2_k127_3835727_2 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 335.0
TLS2_k127_3835727_20 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000002312 100.0
TLS2_k127_3835727_21 Polysaccharide deacetylase - - - 0.000000000000000001543 97.0
TLS2_k127_3835727_22 PFAM Bacterial transferase hexapeptide (three repeats) - - - 0.000000000000001995 87.0
TLS2_k127_3835727_23 Glycosyltransferase like family 2 - - - 0.000000000000004025 88.0
TLS2_k127_3835727_24 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000001228 76.0
TLS2_k127_3835727_25 Uncharacterized conserved protein (DUF2304) K09153 - - 0.00000003783 62.0
TLS2_k127_3835727_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001165 235.0
TLS2_k127_3835727_4 Glycosyltransferase, group 2 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000201 223.0
TLS2_k127_3835727_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000002273 221.0
TLS2_k127_3835727_6 - - - - 0.000000000000000000000000000000000000000000000000000000002675 225.0
TLS2_k127_3835727_7 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000001266 215.0
TLS2_k127_3835727_8 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000002275 202.0
TLS2_k127_3835727_9 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000003422 191.0
TLS2_k127_3845493_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009186 558.0
TLS2_k127_3845493_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 481.0
TLS2_k127_3845493_10 Ribosomal protein L36 K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000003401 75.0
TLS2_k127_3845493_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 311.0
TLS2_k127_3845493_3 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000006772 234.0
TLS2_k127_3845493_4 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000179 228.0
TLS2_k127_3845493_5 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000000000000000000000003185 187.0
TLS2_k127_3845493_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000001901 178.0
TLS2_k127_3845493_7 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000002274 168.0
TLS2_k127_3845493_8 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000003706 166.0
TLS2_k127_3845493_9 Ribosomal protein L30 K02907 - - 0.0000000000000002388 85.0
TLS2_k127_3865838_0 COG4962 Flp pilus assembly protein, ATPase CpaF K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 594.0
TLS2_k127_3865838_1 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 338.0
TLS2_k127_3865838_2 Type II secretion system (T2SS), protein F K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 301.0
TLS2_k127_3865838_3 regulator of chromosome condensation, RCC1 - - - 0.00000000000000000000000000000000000000000000007158 181.0
TLS2_k127_3865838_4 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000002973 165.0
TLS2_k127_387551_0 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 475.0
TLS2_k127_387551_1 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 433.0
TLS2_k127_387551_10 - - - - 0.000000099 62.0
TLS2_k127_387551_2 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 386.0
TLS2_k127_387551_3 COG4942 Membrane-bound metallopeptidase - GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000003207 258.0
TLS2_k127_387551_4 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000000000001231 213.0
TLS2_k127_387551_5 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321 - 0.0000000000000000000000000000000000000000004393 168.0
TLS2_k127_387551_6 YCII-related domain - - - 0.0000000000000000000000000000000009994 132.0
TLS2_k127_387551_7 Rhodanese-related sulfurtransferase - - - 0.00000000000000000000000000052 118.0
TLS2_k127_387551_8 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000007082 108.0
TLS2_k127_387551_9 TIGRFAM flagellar hook-associated protein 3 K02397 - - 0.000000001158 59.0
TLS2_k127_3892255_0 Belongs to the helicase family. UvrD subfamily K03582 - 3.1.11.5 1.972e-224 735.0
TLS2_k127_3892255_1 3-hydroxyacyl-coa dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.44e-208 669.0
TLS2_k127_3892255_10 Glycerophosphoryl diester phosphodiesterase family K01126 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 321.0
TLS2_k127_3892255_11 exonuclease activity K16899 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 336.0
TLS2_k127_3892255_12 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 306.0
TLS2_k127_3892255_13 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006227 277.0
TLS2_k127_3892255_14 PFAM Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003551 268.0
TLS2_k127_3892255_15 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000001374 234.0
TLS2_k127_3892255_16 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000000000000000000000009135 233.0
TLS2_k127_3892255_17 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000000000000000000000000001662 207.0
TLS2_k127_3892255_18 Pilus assembly protein PilZ K02676 - - 0.0000000000000000000000000000000000000000000004492 177.0
TLS2_k127_3892255_19 - - - - 0.000000000000000000000000000000000000000001276 167.0
TLS2_k127_3892255_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 585.0
TLS2_k127_3892255_20 DNA polymerase III, delta' K02341 - 2.7.7.7 0.000000000000000000000000000000000000004654 159.0
TLS2_k127_3892255_21 - - - - 0.000000000000000000000000000000000000007434 154.0
TLS2_k127_3892255_22 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000000000003839 126.0
TLS2_k127_3892255_23 Type II secretion system (T2SS), protein J - - - 0.0000000000000000000000000000004787 135.0
TLS2_k127_3892255_24 membrane protein (homolog of Drosophila rhomboid) - - - 0.000000000000000000000000000001731 128.0
TLS2_k127_3892255_25 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.000000000000000000000000006465 125.0
TLS2_k127_3892255_26 Type II transport protein GspH K02457 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000000000000003624 100.0
TLS2_k127_3892255_27 YfaZ precursor - - - 0.0000000000000000001907 97.0
TLS2_k127_3892255_28 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02462 - - 0.00000000000000001575 91.0
TLS2_k127_3892255_29 Type II secretion system (T2SS), protein I K02458 - - 0.00000000000000003291 87.0
TLS2_k127_3892255_3 L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 471.0
TLS2_k127_3892255_30 PRC-barrel domain - - - 0.000000000000002448 85.0
TLS2_k127_3892255_31 MTH538 TIR-like domain (DUF1863) - - - 0.000000000002389 73.0
TLS2_k127_3892255_32 type II secretion system protein N K02463 - - 0.000001558 58.0
TLS2_k127_3892255_33 Outer membrane lipoprotein-sorting protein - - - 0.00004708 53.0
TLS2_k127_3892255_34 ATP binding - - - 0.0002646 46.0
TLS2_k127_3892255_4 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 448.0
TLS2_k127_3892255_5 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 434.0
TLS2_k127_3892255_6 malonyl CoA-acyl carrier protein transacylase K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 357.0
TLS2_k127_3892255_7 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 355.0
TLS2_k127_3892255_8 electron transfer flavoprotein beta subunit K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 332.0
TLS2_k127_3892255_9 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 331.0
TLS2_k127_389268_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1212.0
TLS2_k127_389268_1 Dehydrogenase E1 component K00164 GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 0.0 1105.0
TLS2_k127_389268_10 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 475.0
TLS2_k127_389268_11 Involved in the TonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 458.0
TLS2_k127_389268_12 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 456.0
TLS2_k127_389268_13 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 444.0
TLS2_k127_389268_14 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 437.0
TLS2_k127_389268_15 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 419.0
TLS2_k127_389268_16 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 390.0
TLS2_k127_389268_17 protein conserved in bacteria (DUF2333) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007453 374.0
TLS2_k127_389268_18 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000976 345.0
TLS2_k127_389268_19 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 331.0
TLS2_k127_389268_2 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 2.791e-265 827.0
TLS2_k127_389268_20 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008338 347.0
TLS2_k127_389268_21 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 319.0
TLS2_k127_389268_22 Preprotein translocase subunit TatD K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 309.0
TLS2_k127_389268_23 Protein of unknown function (DUF1538) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009774 263.0
TLS2_k127_389268_24 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003729 250.0
TLS2_k127_389268_25 PFAM MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000007241 242.0
TLS2_k127_389268_26 Protein of unknown function (DUF1538) - - - 0.000000000000000000000000000000000000000000000000000000000000000000007996 249.0
TLS2_k127_389268_27 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000321 237.0
TLS2_k127_389268_28 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000004323 220.0
TLS2_k127_389268_29 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000001022 214.0
TLS2_k127_389268_3 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 2.829e-253 806.0
TLS2_k127_389268_30 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000003356 184.0
TLS2_k127_389268_31 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000008848 171.0
TLS2_k127_389268_32 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000000000000000000007564 170.0
TLS2_k127_389268_33 Belongs to the P(II) protein family - - - 0.00000000000000000000000000000000000000001651 160.0
TLS2_k127_389268_34 Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000000000000000006054 155.0
TLS2_k127_389268_35 PFAM Class I peptide chain release factor K15034 - - 0.0000000000000000000000000000000000000004928 157.0
TLS2_k127_389268_36 - - - - 0.000000000000000000000000000000000000003213 155.0
TLS2_k127_389268_37 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000002827 148.0
TLS2_k127_389268_39 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000003481 141.0
TLS2_k127_389268_4 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000875 621.0
TLS2_k127_389268_40 Tol-Pal system-associated acyl-CoA thioesterase K07107 - - 0.0000000000000000000000000000000009043 136.0
TLS2_k127_389268_41 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.000000000000000000000000000000363 129.0
TLS2_k127_389268_42 COG3474 Cytochrome c2 K08738 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0016020,GO:0044237,GO:0044464,GO:0071944 - 0.0000000000000000000000000000005998 133.0
TLS2_k127_389268_43 - - - - 0.00000000000000000000001336 110.0
TLS2_k127_389268_44 TonB C terminal K03646 - - 0.0000000000000000000001906 109.0
TLS2_k127_389268_45 protein acetylation - - - 0.0000000000000000000004997 100.0
TLS2_k127_389268_46 N-formylglutamate amidohydrolase - - - 0.0000000000000000000006078 100.0
TLS2_k127_389268_47 NERD domain protein - - - 0.000000000000000005864 91.0
TLS2_k127_389268_48 Immunity protein 32 - - - 0.0000000000126 67.0
TLS2_k127_389268_49 - - - - 0.000000001963 66.0
TLS2_k127_389268_5 COG1473 Metal-dependent amidase aminoacylase carboxypeptidase K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 601.0
TLS2_k127_389268_50 - - - - 0.0000003712 55.0
TLS2_k127_389268_51 CAAX protease self-immunity K07052 - - 0.0004279 51.0
TLS2_k127_389268_6 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 600.0
TLS2_k127_389268_7 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 574.0
TLS2_k127_389268_8 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 519.0
TLS2_k127_389268_9 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 503.0
TLS2_k127_3899697_0 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 478.0
TLS2_k127_3899697_1 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 356.0
TLS2_k127_3899697_2 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000006897 113.0
TLS2_k127_3908226_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0 1526.0
TLS2_k127_3908226_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1031.0
TLS2_k127_3908226_10 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 415.0
TLS2_k127_3908226_11 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007653 415.0
TLS2_k127_3908226_12 succinylglutamate desuccinylase aspartoacylase K06987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005199 384.0
TLS2_k127_3908226_13 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005708 293.0
TLS2_k127_3908226_14 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000252 287.0
TLS2_k127_3908226_15 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003014 238.0
TLS2_k127_3908226_16 PFAM Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000001503 230.0
TLS2_k127_3908226_17 Cysteine dioxygenase type I - - - 0.000000000000000000000000000000000000000000000000000000003492 204.0
TLS2_k127_3908226_18 protein conserved in archaea - - - 0.0000000000000000000000000000000000000000000000000000001152 198.0
TLS2_k127_3908226_19 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000058 182.0
TLS2_k127_3908226_2 HipA-like C-terminal domain K07154 - 2.7.11.1 6.748e-251 778.0
TLS2_k127_3908226_20 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.00000000000000000000000000000000000000000000000001931 183.0
TLS2_k127_3908226_21 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000001009 168.0
TLS2_k127_3908226_22 TIGRFAM Type VI secretion system, FHA K11913 - - 0.000000000000000000000000000000000000000000001084 181.0
TLS2_k127_3908226_23 type IV pilus biogenesis stability protein PilW K02656 - - 0.000000000000000000000000000000000000000002176 166.0
TLS2_k127_3908226_24 Domain of unknown function (DUF1820) - - - 0.0000000000000000000000000000000000000002771 154.0
TLS2_k127_3908226_25 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000000128 144.0
TLS2_k127_3908226_26 Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis K15539 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.000000000000000000009348 102.0
TLS2_k127_3908226_3 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.141e-246 771.0
TLS2_k127_3908226_4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 5.209e-229 718.0
TLS2_k127_3908226_5 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 563.0
TLS2_k127_3908226_6 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 528.0
TLS2_k127_3908226_7 Belongs to the RimK family K05844 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 476.0
TLS2_k127_3908226_8 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 444.0
TLS2_k127_3908226_9 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 435.0
TLS2_k127_3926666_0 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 625.0
TLS2_k127_3926666_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 531.0
TLS2_k127_3926666_2 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004871 281.0
TLS2_k127_3926666_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000007428 163.0
TLS2_k127_3926666_4 Type IV minor pilin ComP, DNA uptake sequence receptor K02655 - - 0.000000000000000000257 93.0
TLS2_k127_3926666_5 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000000000003679 86.0
TLS2_k127_3960410_0 COG0339 Zn-dependent oligopeptidases K01284 GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.5 0.0 1041.0
TLS2_k127_3960410_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit K00316 - 1.5.99.6 0.00000000000000000000000000000000000000000000000000009059 192.0
TLS2_k127_3960410_2 - - - - 0.000000000000000000000000000133 119.0
TLS2_k127_3966514_0 MacB-like periplasmic core domain - - - 3.21e-290 914.0
TLS2_k127_3966514_1 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 539.0
TLS2_k127_3966514_10 SnoaL-like domain - - - 0.0000000000001643 78.0
TLS2_k127_3966514_11 toxic component of a K07065 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000004529 75.0
TLS2_k127_3966514_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 524.0
TLS2_k127_3966514_3 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 424.0
TLS2_k127_3966514_4 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 333.0
TLS2_k127_3966514_5 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 331.0
TLS2_k127_3966514_6 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000004586 230.0
TLS2_k127_3966514_7 - - - - 0.000000000000000000000000000000000000006035 155.0
TLS2_k127_3966514_8 Protein of unknown function (DUF2975) - - - 0.000000000000000000000000000000000000007982 151.0
TLS2_k127_3966514_9 Cro/C1-type HTH DNA-binding domain - - - 0.00000000000000000000000001963 110.0
TLS2_k127_3980371_0 cytochrome C family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 330.0
TLS2_k127_3980371_1 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.0000000000000000000000000000000000000000001646 182.0
TLS2_k127_4062494_0 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004608 275.0
TLS2_k127_4062494_1 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003347 244.0
TLS2_k127_4062494_2 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000002765 218.0
TLS2_k127_4062494_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001556 191.0
TLS2_k127_4062494_4 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000000000000008515 152.0
TLS2_k127_4062494_5 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000000000802 148.0
TLS2_k127_4062494_6 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000002189 115.0
TLS2_k127_4062494_7 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast K02881 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000004998 64.0
TLS2_k127_407349_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 4.316e-201 662.0
TLS2_k127_407349_1 Alcohol dehydrogenase GroES-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 607.0
TLS2_k127_407349_10 mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 343.0
TLS2_k127_407349_11 membrane protein (homolog of Drosophila rhomboid) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 316.0
TLS2_k127_407349_12 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 293.0
TLS2_k127_407349_13 Belongs to the Dps family - - - 0.00000000000000000000000000000000000000000000000000000000000973 220.0
TLS2_k127_407349_14 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000001873 176.0
TLS2_k127_407349_15 Rho termination factor - - - 0.000000000000000000000000000002117 122.0
TLS2_k127_407349_2 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 580.0
TLS2_k127_407349_3 aminotransferase class I and II K14261 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 477.0
TLS2_k127_407349_4 ABC transporter K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005854 466.0
TLS2_k127_407349_5 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 483.0
TLS2_k127_407349_6 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 424.0
TLS2_k127_407349_7 transport, permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 404.0
TLS2_k127_407349_8 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 361.0
TLS2_k127_407349_9 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 357.0
TLS2_k127_4075204_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1017.0
TLS2_k127_4075204_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.299e-303 943.0
TLS2_k127_4075204_10 ECF sigma factor - - - 0.00000000000000000000000000000000000000001799 163.0
TLS2_k127_4075204_11 Tfp pilus assembly protein FimV K08086 - - 0.00000000000000003235 96.0
TLS2_k127_4075204_12 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.000000000000005883 78.0
TLS2_k127_4075204_2 Cysteine-rich domain - - - 9.566e-207 651.0
TLS2_k127_4075204_3 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 537.0
TLS2_k127_4075204_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 377.0
TLS2_k127_4075204_5 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 319.0
TLS2_k127_4075204_6 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001083 267.0
TLS2_k127_4075204_7 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003175 261.0
TLS2_k127_4075204_8 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000001205 240.0
TLS2_k127_4075204_9 Involved in the tonB-independent uptake of proteins K03641,K10117 - - 0.0000000000000000000000000000000000000000000000000000000003402 222.0
TLS2_k127_4091266_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 0.0 1223.0
TLS2_k127_4091266_1 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 503.0
TLS2_k127_4091266_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 484.0
TLS2_k127_4091266_3 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 437.0
TLS2_k127_4091266_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 445.0
TLS2_k127_4091266_5 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000004222 222.0
TLS2_k127_4096098_0 serine threonine protein kinase K11912 - 2.7.11.1 4.031e-202 648.0
TLS2_k127_4096098_10 YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the K09780 - - 0.00000000000000000000000000000000001273 141.0
TLS2_k127_4096098_11 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000005371 126.0
TLS2_k127_4096098_13 OmpA-like transmembrane domain - - - 0.0000000001227 70.0
TLS2_k127_4096098_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 505.0
TLS2_k127_4096098_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 468.0
TLS2_k127_4096098_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 396.0
TLS2_k127_4096098_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007469 383.0
TLS2_k127_4096098_6 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 376.0
TLS2_k127_4096098_7 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 319.0
TLS2_k127_4096098_8 abc transporter atp-binding protein K02003 - - 0.000000000000000000000000000000000000000000000000000000000000002257 231.0
TLS2_k127_4096098_9 regulatory protein LysR - - - 0.00000000000000000000000000000000000000000000000000000000000005986 224.0
TLS2_k127_4100373_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 7.125e-196 621.0
TLS2_k127_4100373_1 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 523.0
TLS2_k127_4100373_10 Histidine kinase K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 345.0
TLS2_k127_4100373_11 lactate racemase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 340.0
TLS2_k127_4100373_12 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005647 329.0
TLS2_k127_4100373_13 transferase activity, transferring glycosyl groups K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009708 306.0
TLS2_k127_4100373_14 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 316.0
TLS2_k127_4100373_15 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002992 276.0
TLS2_k127_4100373_16 Hexapeptide repeat of succinyl-transferase K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000001333 261.0
TLS2_k127_4100373_17 PFAM ExsB family protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001363 273.0
TLS2_k127_4100373_18 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001064 269.0
TLS2_k127_4100373_19 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001956 256.0
TLS2_k127_4100373_2 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003103 485.0
TLS2_k127_4100373_20 Arylsulfotransferase (ASST) - - - 0.00000000000000000000000000000000000000000000000000000000000000002 241.0
TLS2_k127_4100373_21 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000002884 222.0
TLS2_k127_4100373_22 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000008739 222.0
TLS2_k127_4100373_23 AMP-binding enzyme K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000003584 178.0
TLS2_k127_4100373_24 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000007957 156.0
TLS2_k127_4100373_25 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000001144 135.0
TLS2_k127_4100373_26 homoserine kinase activity - - - 0.000000000000000000000000000003235 140.0
TLS2_k127_4100373_27 Membrane protein involved in the export of O-antigen and teichoic - - - 0.0000000000000000000000001602 120.0
TLS2_k127_4100373_28 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000002232 109.0
TLS2_k127_4100373_29 - - - - 0.000000000000000000003582 94.0
TLS2_k127_4100373_3 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 481.0
TLS2_k127_4100373_30 Sulfotransferase family - - - 0.000000000000003664 86.0
TLS2_k127_4100373_31 - - - - 0.00000000000009752 75.0
TLS2_k127_4100373_32 - - - - 0.000000005287 59.0
TLS2_k127_4100373_33 Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin K18843 - - 0.0000004763 53.0
TLS2_k127_4100373_34 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0001538 53.0
TLS2_k127_4100373_4 PFAM NAD dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000765 436.0
TLS2_k127_4100373_5 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 440.0
TLS2_k127_4100373_6 Oxidoreductase family, NAD-binding Rossmann fold K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 381.0
TLS2_k127_4100373_7 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 376.0
TLS2_k127_4100373_8 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 364.0
TLS2_k127_4100373_9 UDP-N-acetylglucosamine 2-epimerase K01791,K13019 - 5.1.3.14,5.1.3.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 350.0
TLS2_k127_4157123_0 TonB dependent receptor K02014 - - 7.081e-240 774.0
TLS2_k127_4157123_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008974 329.0
TLS2_k127_4157123_2 endonuclease activity - - - 0.00002496 49.0
TLS2_k127_4181338_0 Tfp pilus assembly protein tip-associated adhesin PilY1 K02674 - - 0.0 1152.0
TLS2_k127_4181338_1 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 2.172e-275 874.0
TLS2_k127_4181338_10 COG3103 SH3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004364 272.0
TLS2_k127_4181338_11 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007722 246.0
TLS2_k127_4181338_12 Eukaryotic integral membrane protein (DUF1751) K09650 - 3.4.21.105 0.00000000000000000000000000000000000000000000000000000000000000002255 231.0
TLS2_k127_4181338_13 pilus assembly protein PilW K02672 - - 0.000000000000000000000000000000000000000000000000000000001092 218.0
TLS2_k127_4181338_14 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000000000000000000001657 187.0
TLS2_k127_4181338_15 proteolysis - - - 0.00000000000000000000000000000000000000000000003472 181.0
TLS2_k127_4181338_16 LemA family - - - 0.0000000000000000000000000000000000000000000005114 172.0
TLS2_k127_4181338_17 MOSC domain - - - 0.0000000000000000000000000000000000000000009258 165.0
TLS2_k127_4181338_18 ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000004513 164.0
TLS2_k127_4181338_19 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000003958 146.0
TLS2_k127_4181338_2 Concanavalin A-like lectin/glucanases superfamily - - - 4.845e-274 866.0
TLS2_k127_4181338_20 COG4968 Tfp pilus assembly protein PilE K02655 - - 0.000000000000000000000000000004207 125.0
TLS2_k127_4181338_21 TIGRFAM type IV pilus modification protein PilV K02671 - - 0.00000000000000000000000000003653 122.0
TLS2_k127_4181338_22 Domain of unknown function (DUF4266) - - - 0.000000000000000000000000264 106.0
TLS2_k127_4181338_23 Type II transport protein GspH K08084 - - 0.000000000000000000000001299 111.0
TLS2_k127_4181338_24 Pilus assembly protein PilX K02673 - - 0.000000000000000000000008472 108.0
TLS2_k127_4181338_26 N2227 K19787 - 2.1.1.22 0.00000001123 68.0
TLS2_k127_4181338_3 enoyl-CoA hydratase K07516 - 1.1.1.35 5.04e-227 724.0
TLS2_k127_4181338_4 - - - - 6.707e-223 703.0
TLS2_k127_4181338_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 482.0
TLS2_k127_4181338_6 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 422.0
TLS2_k127_4181338_7 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 425.0
TLS2_k127_4181338_8 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 314.0
TLS2_k127_4181338_9 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 288.0
TLS2_k127_4193316_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 3.474e-263 829.0
TLS2_k127_4193316_1 xaa-pro aminopeptidase - - - 1.262e-212 669.0
TLS2_k127_4193316_10 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005896 359.0
TLS2_k127_4193316_11 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 338.0
TLS2_k127_4193316_12 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 320.0
TLS2_k127_4193316_13 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 316.0
TLS2_k127_4193316_14 COG3023 Negative regulator of beta-lactamase expression K01447,K03806,K11066 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 295.0
TLS2_k127_4193316_15 thiolester hydrolase activity K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000194 293.0
TLS2_k127_4193316_16 PFAM Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001275 245.0
TLS2_k127_4193316_17 - - - - 0.000000000000000000000000000000000000000000000000000000007231 211.0
TLS2_k127_4193316_18 Protein of unknown function (DUF4199) - - - 0.0000000000000000000000000000000000000000000000000002428 191.0
TLS2_k127_4193316_19 ECF sigma factor - - - 0.000000000000000000000000000000000000000000393 164.0
TLS2_k127_4193316_2 Belongs to the EPSP synthase family. MurA subfamily K00790 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 602.0
TLS2_k127_4193316_20 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000001055 157.0
TLS2_k127_4193316_21 transcriptional regulator - - - 0.00000000000000000000000000000000000000005958 166.0
TLS2_k127_4193316_22 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000001188 161.0
TLS2_k127_4193316_23 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000000000000000000000000000000000000001205 151.0
TLS2_k127_4193316_24 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000005845 149.0
TLS2_k127_4193316_25 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000000000006027 149.0
TLS2_k127_4193316_26 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000002002 133.0
TLS2_k127_4193316_27 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000001607 131.0
TLS2_k127_4193316_28 Belongs to the mandelate racemase muconate lactonizing enzyme family K19802 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 0.00000000000000000000000000915 116.0
TLS2_k127_4193316_29 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000003197 97.0
TLS2_k127_4193316_3 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 542.0
TLS2_k127_4193316_30 Helix-turn-helix domain K07726 - - 0.000000000000000000002015 96.0
TLS2_k127_4193316_31 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.00000000000000000035 90.0
TLS2_k127_4193316_32 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.00000000001709 74.0
TLS2_k127_4193316_33 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.0000000000967 65.0
TLS2_k127_4193316_34 YCII-related domain - - - 0.0000000001811 71.0
TLS2_k127_4193316_35 - - - - 0.0000003356 60.0
TLS2_k127_4193316_36 TonB-dependent receptor - - - 0.0005712 47.0
TLS2_k127_4193316_37 LD-carboxypeptidase K01297 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.4.17.13 0.0006339 46.0
TLS2_k127_4193316_4 BT1 family K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005828 537.0
TLS2_k127_4193316_5 COG0402 Cytosine deaminase and related metal-dependent hydrolases K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008508 497.0
TLS2_k127_4193316_6 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 466.0
TLS2_k127_4193316_7 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 433.0
TLS2_k127_4193316_8 FAD linked oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 412.0
TLS2_k127_4193316_9 deacetylase K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 381.0
TLS2_k127_4224803_0 TonB dependent receptor - - - 3.844e-234 746.0
TLS2_k127_4224803_1 amidohydrolase K01468 - 3.5.2.7 3.619e-215 685.0
TLS2_k127_4224803_2 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 591.0
TLS2_k127_4224803_3 Belongs to the DapA family K01714,K21062 - 3.5.4.22,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 422.0
TLS2_k127_4224803_4 Belongs to the proline racemase family K12658 - 5.1.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000005134 250.0
TLS2_k127_4224803_5 FCD - - - 0.000000000000000000000000000000000000000000000000000000729 200.0
TLS2_k127_4241753_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 3.678e-266 827.0
TLS2_k127_4241753_1 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000007642 161.0
TLS2_k127_4241753_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000002087 151.0
TLS2_k127_4249774_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.111e-284 888.0
TLS2_k127_4249774_1 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 462.0
TLS2_k127_4249774_10 Part of a membrane complex involved in electron transport K03616 - - 0.000000000000000000000000000000000000000000000000008436 186.0
TLS2_k127_4249774_11 Part of a membrane complex involved in electron transport K03612 - - 0.0000000000000000000000000000000000000000000001113 188.0
TLS2_k127_4249774_12 Domain of unknown function (DUF1841) - - - 0.0000000000000000000000000000000000004379 153.0
TLS2_k127_4249774_13 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000004021 135.0
TLS2_k127_4249774_2 Belongs to the UPF0276 family K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 377.0
TLS2_k127_4249774_3 Domain of unknown function (DUF4143) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 372.0
TLS2_k127_4249774_4 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 365.0
TLS2_k127_4249774_5 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008067 321.0
TLS2_k127_4249774_6 Part of a membrane complex involved in electron transport K03617 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001456 261.0
TLS2_k127_4249774_7 Putative DNA-binding domain K09929 - - 0.0000000000000000000000000000000000000000000000000000000000000000001347 239.0
TLS2_k127_4249774_8 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000000000000000000009491 231.0
TLS2_k127_4249774_9 DoxX K15977 - - 0.000000000000000000000000000000000000000000000000000000004183 205.0
TLS2_k127_4267585_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 1.919e-265 833.0
TLS2_k127_4267585_1 peptidase M20 - - - 1.06e-200 640.0
TLS2_k127_4267585_10 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 309.0
TLS2_k127_4267585_11 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004152 287.0
TLS2_k127_4267585_12 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005487 295.0
TLS2_k127_4267585_13 Putative member of DMT superfamily (DUF486) K09922 - - 0.000000000000000000000000000000000000000000000000000000004642 201.0
TLS2_k127_4267585_14 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000001439 208.0
TLS2_k127_4267585_15 COG2030 Acyl dehydratase - - - 0.000000000000000000000000000000000000000000002394 171.0
TLS2_k127_4267585_16 helix_turn_helix ASNC type K03719 - - 0.00000000000000000000000000000000000000006604 155.0
TLS2_k127_4267585_17 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000512 153.0
TLS2_k127_4267585_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000008749 147.0
TLS2_k127_4267585_19 - - - - 0.00000000000000000000000000000002664 126.0
TLS2_k127_4267585_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 9.231e-195 623.0
TLS2_k127_4267585_20 Redoxin - - - 0.00000000000000000000000000001321 125.0
TLS2_k127_4267585_21 Protein of unknown function (DUF2905) - - - 0.000000000000000000000007657 102.0
TLS2_k127_4267585_22 - - - - 0.0000000000000000005062 92.0
TLS2_k127_4267585_23 Dodecin K09165 - - 0.000000000000000003646 86.0
TLS2_k127_4267585_3 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 572.0
TLS2_k127_4267585_4 sodium proton antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 561.0
TLS2_k127_4267585_5 PFAM D-aminoacylase, C-terminal region K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000827 566.0
TLS2_k127_4267585_6 4-hydroxyphenylpyruvate dioxygenase K00457 - 1.13.11.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 499.0
TLS2_k127_4267585_7 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 405.0
TLS2_k127_4267585_8 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 388.0
TLS2_k127_4267585_9 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008645 379.0
TLS2_k127_439901_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.792e-200 632.0
TLS2_k127_439901_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.331e-195 626.0
TLS2_k127_439901_10 ATP ADP translocase K03301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 364.0
TLS2_k127_439901_11 PFAM Polyphosphate kinase 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 351.0
TLS2_k127_439901_12 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 345.0
TLS2_k127_439901_13 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 332.0
TLS2_k127_439901_14 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 323.0
TLS2_k127_439901_15 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 317.0
TLS2_k127_439901_16 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 311.0
TLS2_k127_439901_17 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 302.0
TLS2_k127_439901_18 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004847 285.0
TLS2_k127_439901_19 COG1428 Deoxynucleoside kinases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000137 261.0
TLS2_k127_439901_2 N-terminal domain of (some) glycogen debranching enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 622.0
TLS2_k127_439901_20 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006729 263.0
TLS2_k127_439901_21 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003156 241.0
TLS2_k127_439901_22 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000415 227.0
TLS2_k127_439901_23 Glycosyl transferase family group 2 K00694,K01210 - 2.4.1.12,3.2.1.58 0.000000000000000000000000000000000000000000000000000000001642 224.0
TLS2_k127_439901_24 Permease YjgP YjgQ K11720 - - 0.0000000000000000000000000000000000000000000000000000001265 209.0
TLS2_k127_439901_25 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000000000001463 182.0
TLS2_k127_439901_26 Protein of unknown function (DUF2799) - - - 0.0000000000000000000000000000000000009523 147.0
TLS2_k127_439901_27 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000007251 137.0
TLS2_k127_439901_28 RDD family - - - 0.000000000000000000000000000000003617 132.0
TLS2_k127_439901_29 ATPase or kinase K06925 - - 0.000000000000000000000000000002313 138.0
TLS2_k127_439901_3 Calx-beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 600.0
TLS2_k127_439901_30 MAPEG family - - - 0.000000000000000000000000001046 121.0
TLS2_k127_439901_31 positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0000000000000000000002882 96.0
TLS2_k127_439901_32 - - - - 0.00000000000000529 82.0
TLS2_k127_439901_33 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000002067 66.0
TLS2_k127_439901_34 BON domain - - - 0.00000000493 62.0
TLS2_k127_439901_35 permease K07091 - - 0.0000001568 54.0
TLS2_k127_439901_36 Recombinase - - - 0.0003575 48.0
TLS2_k127_439901_4 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009918 552.0
TLS2_k127_439901_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 509.0
TLS2_k127_439901_6 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 482.0
TLS2_k127_439901_7 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 477.0
TLS2_k127_439901_8 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 444.0
TLS2_k127_439901_9 Cell wall hydrolase autolysin K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 405.0
TLS2_k127_4443816_0 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000021 148.0
TLS2_k127_4443816_1 Pfam cytochrome c - - - 0.000000000000000000000000000000000001248 147.0
TLS2_k127_444464_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.0 1253.0
TLS2_k127_444464_1 Mandelate racemase muconate lactonizing enzyme K08323 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575 4.2.1.8 3.01e-237 737.0
TLS2_k127_444464_10 Plasmid maintenance protein CcdB K19163 - - 0.00000000003129 70.0
TLS2_k127_444464_11 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid K19164 - - 0.00000003243 59.0
TLS2_k127_444464_2 Belongs to the glycosyl hydrolase 43 family K01198,K01209 - 3.2.1.37,3.2.1.55 1.74e-220 749.0
TLS2_k127_444464_3 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 511.0
TLS2_k127_444464_4 GntP family permease K03299,K06156 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 468.0
TLS2_k127_444464_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 464.0
TLS2_k127_444464_6 Glycosyl hydrolase family 10 K01181 - 3.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 455.0
TLS2_k127_444464_7 PFAM helix-turn-helix domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 338.0
TLS2_k127_444464_8 histidine kinase HAMP region domain protein K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000008324 206.0
TLS2_k127_444464_9 - - - - 0.0000000000000000002549 94.0
TLS2_k127_4474704_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 4.278e-306 948.0
TLS2_k127_4474704_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 4.575e-217 683.0
TLS2_k127_4474704_10 PFAM Anti sigma-E protein RseA K03597 - - 0.00001405 51.0
TLS2_k127_4474704_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 524.0
TLS2_k127_4474704_3 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 417.0
TLS2_k127_4474704_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002784 255.0
TLS2_k127_4474704_5 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000191 154.0
TLS2_k127_4474704_6 succinate dehydrogenase K00242 - - 0.0000000000000000000000000000003956 132.0
TLS2_k127_4474704_7 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.0000000000000000000000000001294 119.0
TLS2_k127_4474704_8 An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH K00240,K09159 GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 1.3.5.1,1.3.5.4 0.00000000001861 68.0
TLS2_k127_4474704_9 Protein of unknown function (DUF1674) - - - 0.0000005163 55.0
TLS2_k127_4664614_0 ADP-glyceromanno-heptose 6-epimerase activity K01784,K12454 - 5.1.3.10,5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 495.0
TLS2_k127_4664614_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 331.0
TLS2_k127_4664614_2 3-demethylubiquinone-9 3-O-methyltransferase activity K00694,K11936,K20541 - 2.4.1.12 0.0000000000000000000000000000000007061 144.0
TLS2_k127_4693683_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 5.161e-220 692.0
TLS2_k127_4693683_1 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005123 287.0
TLS2_k127_4693683_2 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000001018 252.0
TLS2_k127_4693683_3 COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA K06169 - - 0.00000000000000000000000000000000000000000000000000000000000003952 226.0
TLS2_k127_4693683_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000003548 194.0
TLS2_k127_4693683_5 - - - - 0.0000000000009922 73.0
TLS2_k127_4693683_7 - - - - 0.0007427 42.0
TLS2_k127_4698476_0 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 322.0
TLS2_k127_4698476_1 Tryptophan-rich sensory protein K05770 - - 0.00000000000000000000000000000000000000000000000000000000000000366 221.0
TLS2_k127_4698476_2 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000000000000000009569 198.0
TLS2_k127_4698476_3 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000002308 179.0
TLS2_k127_4698476_4 Putative prokaryotic signal transducing protein - - - 0.000000000000000000000000000000000000004016 153.0
TLS2_k127_4698476_5 - - - - 0.00000000006788 66.0
TLS2_k127_4698483_0 histidine kinase HAMP region domain protein K07716 - 2.7.13.3 0.0 1752.0
TLS2_k127_4698483_1 Outer membrane receptor - - - 0.00000002266 63.0
TLS2_k127_4726102_0 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 516.0
TLS2_k127_4726102_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000007377 176.0
TLS2_k127_4726102_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000002805 82.0
TLS2_k127_4735923_0 Amidohydrolase family - - - 0.0 1374.0
TLS2_k127_4735923_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06158 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 3.089e-226 721.0
TLS2_k127_4735923_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009934 606.0
TLS2_k127_4735923_3 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 496.0
TLS2_k127_4735923_4 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 443.0
TLS2_k127_4735923_5 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 382.0
TLS2_k127_4735923_6 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003712 280.0
TLS2_k127_4735923_7 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000003315 193.0
TLS2_k127_4735923_8 PFAM Peptidase S41 - - - 0.00003999 49.0
TLS2_k127_4744277_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 590.0
TLS2_k127_4744277_1 Glycosyl Hydrolase Family 88 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 353.0
TLS2_k127_4744277_2 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007574 270.0
TLS2_k127_4744277_3 - - - - 0.0000000000000000000000000005539 126.0
TLS2_k127_4744277_4 PIN domain K07065 - - 0.0000000000000000000432 91.0
TLS2_k127_4744277_5 Belongs to the 'phage' integrase family - - - 0.0000000000000000001287 91.0
TLS2_k127_4746342_0 Belongs to the glycosyl hydrolase 31 family K01811,K18820 - 2.4.1.161,3.2.1.177 0.0 1356.0
TLS2_k127_4746342_1 GMC oxidoreductase - - - 1.913e-282 875.0
TLS2_k127_4746342_10 Gluconate 2-dehydrogenase subunit 3 - - - 0.0000000000000000000000000000000000000000000000000000000000001071 218.0
TLS2_k127_4746342_2 Bacterial protein of unknown function (DUF885) - - - 4.414e-245 773.0
TLS2_k127_4746342_3 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 587.0
TLS2_k127_4746342_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K21624 GO:0000287,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0016597,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0031406,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043200,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046872,GO:0050896,GO:0051716,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:1901564,GO:1901605,GO:1901698,GO:1901699,GO:1901700,GO:1901701 4.2.1.171 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 514.0
TLS2_k127_4746342_5 Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 359.0
TLS2_k127_4746342_6 Belongs to the proline racemase family K12658 - 5.1.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 342.0
TLS2_k127_4746342_7 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 344.0
TLS2_k127_4746342_8 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003254 254.0
TLS2_k127_4746342_9 Protein of unknown function (DUF2959) - - - 0.00000000000000000000000000000000000000000000000000000000000000000005657 240.0
TLS2_k127_4765646_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0 1183.0
TLS2_k127_4765646_1 TonB-dependent receptor - - - 6.573e-219 714.0
TLS2_k127_4765646_10 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000003534 200.0
TLS2_k127_4765646_11 Domain of unknown function (DUF4382) - - - 0.00000000000000000000000001298 120.0
TLS2_k127_4765646_12 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0001242 44.0
TLS2_k127_4765646_2 Dehydrogenase - - - 1.51e-207 657.0
TLS2_k127_4765646_3 Alpha-L-arabinofuranosidase C-terminus K01209 - 3.2.1.55 4.665e-195 621.0
TLS2_k127_4765646_4 succinyl-diaminopimelate desuccinylase activity K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006446 464.0
TLS2_k127_4765646_5 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 412.0
TLS2_k127_4765646_6 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 414.0
TLS2_k127_4765646_7 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 308.0
TLS2_k127_4765646_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000001186 220.0
TLS2_k127_4765646_9 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000001469 213.0
TLS2_k127_4782176_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 377.0
TLS2_k127_4782176_1 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K00857,K01920,K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.21,6.3.2.3,6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 324.0
TLS2_k127_4782176_2 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007592 282.0
TLS2_k127_4782176_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000002647 276.0
TLS2_k127_4782176_4 Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001386 259.0
TLS2_k127_4782176_5 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000793 222.0
TLS2_k127_4782176_6 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000002198 217.0
TLS2_k127_4782176_7 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.0000000000000000000000000000000000000000000000000000001332 211.0
TLS2_k127_4782176_8 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000004293 96.0
TLS2_k127_4788607_0 self proteolysis K03466,K06196,K12132 - 2.7.11.1 6.168e-205 664.0
TLS2_k127_4788607_1 Bacterial regulatory helix-turn-helix proteins, AraC family - - - 0.000000000000000000000000000000000000000000001312 175.0
TLS2_k127_479901_0 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008118 592.0
TLS2_k127_479901_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 451.0
TLS2_k127_479901_2 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004626 317.0
TLS2_k127_479901_3 dehydratase - - - 0.00000000000000000000000000000000000000000008095 163.0
TLS2_k127_4817862_0 AP endonuclease 2 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 603.0
TLS2_k127_4817862_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 496.0
TLS2_k127_4817862_2 Nucleoside H+ symporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 448.0
TLS2_k127_4817862_3 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 397.0
TLS2_k127_4817862_4 COG2303 Choline dehydrogenase and related flavoproteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 384.0
TLS2_k127_4817862_5 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002981 260.0
TLS2_k127_4817862_6 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000001986 217.0
TLS2_k127_4823153_0 PFAM NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1441.0
TLS2_k127_4823153_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 346.0
TLS2_k127_4823153_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 312.0
TLS2_k127_4823153_3 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000006579 54.0
TLS2_k127_4876518_0 amine dehydrogenase activity - - - 8.098e-316 996.0
TLS2_k127_4876518_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 2.785e-291 914.0
TLS2_k127_4876518_10 Zn-dependent dipeptidase, microsomal dipeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 296.0
TLS2_k127_4876518_11 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000911 273.0
TLS2_k127_4876518_12 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000003434 189.0
TLS2_k127_4876518_13 - - - - 0.00000000000000000000000000000000000000000000000007841 189.0
TLS2_k127_4876518_14 Protease prsW family - - - 0.0000000000000000000000000000000000000000000003407 181.0
TLS2_k127_4876518_15 transcriptional K05799 - - 0.0000000000000000000000000000000000024 149.0
TLS2_k127_4876518_16 Cold shock protein domain K03704 - - 0.00000000000000000000000000000009864 124.0
TLS2_k127_4876518_17 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000001035 128.0
TLS2_k127_4876518_18 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000506 124.0
TLS2_k127_4876518_19 PFAM sigma-70 region 2 domain protein K03088 - - 0.0000000000000000000000000000007053 128.0
TLS2_k127_4876518_2 PFAM peptidase S45 penicillin amidase K07116 - 3.5.1.97 2.203e-264 836.0
TLS2_k127_4876518_20 STAS domain - - - 0.00000000001397 69.0
TLS2_k127_4876518_21 stage II sporulation protein E K07315 - 3.1.3.3 0.000000001518 66.0
TLS2_k127_4876518_3 acid phosphatase K14379 - 3.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 559.0
TLS2_k127_4876518_4 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 549.0
TLS2_k127_4876518_5 COG5265 ABC-type transport system involved in Fe-S cluster assembly permease and ATPase components K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007154 403.0
TLS2_k127_4876518_6 Outer membrane receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 383.0
TLS2_k127_4876518_7 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005717 374.0
TLS2_k127_4876518_8 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 347.0
TLS2_k127_4876518_9 Protein phosphatase 2C domain K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 310.0
TLS2_k127_4919035_0 chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003447 276.0
TLS2_k127_4919035_1 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000004138 174.0
TLS2_k127_4925638_0 amine dehydrogenase activity K17285 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 513.0
TLS2_k127_4925638_1 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.000000000000000000000000000000000000000000000000000000000000000006658 229.0
TLS2_k127_4925638_2 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000000000000001577 218.0
TLS2_k127_4952004_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 3.891e-198 626.0
TLS2_k127_4952004_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 593.0
TLS2_k127_4952004_2 including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 484.0
TLS2_k127_4952004_3 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 447.0
TLS2_k127_4952004_4 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000006502 285.0
TLS2_k127_4952004_5 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000001957 220.0
TLS2_k127_4952004_6 - - - - 0.000000000000000000000000000000003248 136.0
TLS2_k127_4952004_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000001422 138.0
TLS2_k127_496835_0 Beta-lactamase - - - 6.666e-225 715.0
TLS2_k127_496835_1 Amidohydrolase family K06015 - 3.5.1.81 5.308e-218 690.0
TLS2_k127_496835_2 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 489.0
TLS2_k127_496835_3 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008834 321.0
TLS2_k127_496835_4 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 309.0
TLS2_k127_496835_5 transcriptional regulator - - - 0.0000004763 53.0
TLS2_k127_4969972_0 sodium:proton antiporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006425 458.0
TLS2_k127_4969972_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 423.0
TLS2_k127_4969972_2 Leukotriene A4 hydrolase, C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007386 399.0
TLS2_k127_4969972_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000792 396.0
TLS2_k127_4969972_4 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 335.0
TLS2_k127_4969972_5 - - - - 0.00000000000000001338 83.0
TLS2_k127_4970614_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 3.612e-285 886.0
TLS2_k127_4970614_1 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008335 491.0
TLS2_k127_4970614_10 PFAM EAL domain K21025 - - 0.0000000000000000006671 91.0
TLS2_k127_4970614_11 COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor) K02398 - - 0.00000002341 59.0
TLS2_k127_4970614_12 Flagellar biosynthesis type III secretory pathway chaperone K02399 - - 0.0001093 52.0
TLS2_k127_4970614_2 Flagellar hook protein FlgE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 466.0
TLS2_k127_4970614_3 basal body rod protein K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 399.0
TLS2_k127_4970614_4 flagellar basal body K02391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003476 272.0
TLS2_k127_4970614_5 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.000000000000000000000000000000000000000000000000000000003944 213.0
TLS2_k127_4970614_6 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.00000000000000000000000000000000000000000000000004442 186.0
TLS2_k127_4970614_7 Belongs to the flagella basal body rod proteins family K02388 - - 0.00000000000000000000000000000000000000001105 161.0
TLS2_k127_4970614_8 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.0000000000000000000000000000000000000000508 163.0
TLS2_k127_4970614_9 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.0000000000000000000000000000002016 132.0
TLS2_k127_4977121_0 glucose sorbosone K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 538.0
TLS2_k127_4977121_1 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000007517 220.0
TLS2_k127_4977121_2 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000004329 183.0
TLS2_k127_4977121_3 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon K03524 GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 0.0000000000000000000000000000000003639 139.0
TLS2_k127_4977121_4 DNA-binding transcription factor activity K03892 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000002165 114.0
TLS2_k127_4992109_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 546.0
TLS2_k127_4992109_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 406.0
TLS2_k127_5024071_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 588.0
TLS2_k127_5024071_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000008789 243.0
TLS2_k127_5024071_2 Cytochrome C1 family K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000004147 229.0
TLS2_k127_5024071_3 Trypsin K04691 - - 0.000000000000000000000000005975 117.0
TLS2_k127_511397_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1277.0
TLS2_k127_511397_1 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 4.267e-256 806.0
TLS2_k127_511397_10 Na H antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 496.0
TLS2_k127_511397_11 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 503.0
TLS2_k127_511397_12 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 441.0
TLS2_k127_511397_13 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 395.0
TLS2_k127_511397_14 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 392.0
TLS2_k127_511397_15 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 389.0
TLS2_k127_511397_16 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 377.0
TLS2_k127_511397_17 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 317.0
TLS2_k127_511397_18 epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000691 312.0
TLS2_k127_511397_19 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase K16165 - 3.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 301.0
TLS2_k127_511397_2 amidohydrolase K12941 - - 4.657e-230 722.0
TLS2_k127_511397_20 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001069 284.0
TLS2_k127_511397_21 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001198 280.0
TLS2_k127_511397_22 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009875 279.0
TLS2_k127_511397_23 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001024 281.0
TLS2_k127_511397_24 Threonyl and Alanyl tRNA synthetase second additional domain K07050 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008035 271.0
TLS2_k127_511397_25 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003787 262.0
TLS2_k127_511397_26 Peptidase_C39 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005951 248.0
TLS2_k127_511397_27 Thioesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000001971 231.0
TLS2_k127_511397_28 Outer membrane protein beta-barrel domain - - - 0.000000000000000000199 97.0
TLS2_k127_511397_29 Cytochrome C' - - - 0.00000000000000003178 88.0
TLS2_k127_511397_3 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.086e-207 660.0
TLS2_k127_511397_30 Tryptophan halogenase K14266 - 1.14.19.9 0.0000000000000000753 83.0
TLS2_k127_511397_31 - - - - 0.00000000000001444 79.0
TLS2_k127_511397_4 Tryptophan halogenase K14266 - 1.14.19.9 2.944e-203 646.0
TLS2_k127_511397_5 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 6.368e-196 635.0
TLS2_k127_511397_6 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 570.0
TLS2_k127_511397_7 Na H antiporter K03315 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 562.0
TLS2_k127_511397_8 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009261 542.0
TLS2_k127_511397_9 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 510.0
TLS2_k127_5124319_0 Hsp90 protein K04079 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - 1.09e-249 784.0
TLS2_k127_5124319_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 2.229e-238 769.0
TLS2_k127_5124319_10 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 440.0
TLS2_k127_5124319_11 twitching motility protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 427.0
TLS2_k127_5124319_12 Transcriptional regulator K06714,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 434.0
TLS2_k127_5124319_13 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 407.0
TLS2_k127_5124319_14 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 392.0
TLS2_k127_5124319_15 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 390.0
TLS2_k127_5124319_16 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 369.0
TLS2_k127_5124319_17 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 338.0
TLS2_k127_5124319_18 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 333.0
TLS2_k127_5124319_19 Lipid A biosynthesis K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005181 282.0
TLS2_k127_5124319_2 Domain of unknown function (DUF4478) K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 617.0
TLS2_k127_5124319_20 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000001045 269.0
TLS2_k127_5124319_21 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001661 255.0
TLS2_k127_5124319_22 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000001845 227.0
TLS2_k127_5124319_23 abc transporter atp-binding protein K05847 GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337 - 0.000000000000000000000000000000000000000000000000000000000000004157 225.0
TLS2_k127_5124319_24 transport system, ATPase component K02013,K05776 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.34 0.00000000000000000000000000000000000000000000000000001434 197.0
TLS2_k127_5124319_25 PFAM Methionine sulfoxide reductase B K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000001247 189.0
TLS2_k127_5124319_26 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000001877 187.0
TLS2_k127_5124319_27 Phosphoserine phosphatase - - - 0.0000000000000000000000000000000000000000000000007716 181.0
TLS2_k127_5124319_28 alpha beta - - - 0.000000000000000000000000000000000000000000000002701 183.0
TLS2_k127_5124319_29 RIO1 family K11211 - 2.7.1.166 0.00000000000000000000000000000000000000000000006439 179.0
TLS2_k127_5124319_3 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 565.0
TLS2_k127_5124319_30 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000001623 162.0
TLS2_k127_5124319_31 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000004025 154.0
TLS2_k127_5124319_32 integral membrane protein K02221 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000001627 150.0
TLS2_k127_5124319_34 Belongs to the bacterial histone-like protein family - - - 0.000000000000000000000000000000009958 132.0
TLS2_k127_5124319_35 in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon K13634 - - 0.000000000000000000000000001568 115.0
TLS2_k127_5124319_36 Domain of unknown function (DUF4426) - - - 0.000000000000000000000002177 108.0
TLS2_k127_5124319_37 Zinc-finger domain - - - 0.00000000000000000000001242 102.0
TLS2_k127_5124319_38 NADH ubiquinone oxidoreductase 41 kD complex I subunit - - - 0.000000000000005373 87.0
TLS2_k127_5124319_39 PFAM Integral membrane protein TerC K05794 - - 0.000000000000005922 77.0
TLS2_k127_5124319_4 PFAM Aminotransferase class-III K00819 - 2.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 557.0
TLS2_k127_5124319_40 SH3 domain protein K07184 - - 0.0002371 51.0
TLS2_k127_5124319_5 twitching motility protein K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 542.0
TLS2_k127_5124319_6 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 546.0
TLS2_k127_5124319_7 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 511.0
TLS2_k127_5124319_8 MatE - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006862,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015215,GO:0015230,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0034220,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0044610,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 514.0
TLS2_k127_5124319_9 M COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) K05845,K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 443.0
TLS2_k127_5141913_0 Tetratricopeptide repeat - - - 1.356e-222 722.0
TLS2_k127_5141913_1 Acyltransferase - - - 1.166e-216 690.0
TLS2_k127_5141913_10 - - - - 0.00000000000000000000000000000000000000000000000000000002905 201.0
TLS2_k127_5141913_11 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000002957 198.0
TLS2_k127_5141913_12 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000000000001793 190.0
TLS2_k127_5141913_13 Biopolymer transport protein ExbD/TolR - - - 0.000000000000000000000000000000000000002003 152.0
TLS2_k127_5141913_14 Biopolymer transport protein ExbD/TolR - - - 0.0000000000000000000000000000000001167 138.0
TLS2_k127_5141913_15 Tetratricopeptide repeat - - - 0.000000000000000000000001935 113.0
TLS2_k127_5141913_16 - - - - 0.000000000000000004497 89.0
TLS2_k127_5141913_2 Transcriptional regulator, XRE family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006805 540.0
TLS2_k127_5141913_3 Zn-dependent protease with chaperone function K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 480.0
TLS2_k127_5141913_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007223 416.0
TLS2_k127_5141913_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 335.0
TLS2_k127_5141913_6 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001848 267.0
TLS2_k127_5141913_7 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001148 267.0
TLS2_k127_5141913_8 AAA-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000001177 250.0
TLS2_k127_5141913_9 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000002358 215.0
TLS2_k127_5343340_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1337.0
TLS2_k127_5343340_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.697e-255 797.0
TLS2_k127_5343340_10 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 331.0
TLS2_k127_5343340_11 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 314.0
TLS2_k127_5343340_12 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 297.0
TLS2_k127_5343340_13 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003622 279.0
TLS2_k127_5343340_14 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001691 267.0
TLS2_k127_5343340_15 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000009263 219.0
TLS2_k127_5343340_16 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.000000000000000000000000000000000000000000000006563 182.0
TLS2_k127_5343340_17 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59 0.0000000000000000000000000000000000000000001078 164.0
TLS2_k127_5343340_18 Belongs to the skp family K06142 - - 0.0000000000000000000000000000005669 128.0
TLS2_k127_5343340_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 1.14e-199 655.0
TLS2_k127_5343340_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 453.0
TLS2_k127_5343340_4 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 441.0
TLS2_k127_5343340_5 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 413.0
TLS2_k127_5343340_6 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 360.0
TLS2_k127_5343340_7 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 353.0
TLS2_k127_5343340_8 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 329.0
TLS2_k127_5343340_9 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 334.0
TLS2_k127_5364997_0 Domain of unknown function (DUF1974) K06445 - - 1.642e-280 887.0
TLS2_k127_5364997_1 Hydroxymethylglutaryl-coenzyme A reductase K00054 - 1.1.1.88 5.758e-214 687.0
TLS2_k127_5364997_10 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 320.0
TLS2_k127_5364997_11 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 323.0
TLS2_k127_5364997_12 GHMP kinases N terminal domain K01597 - 4.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 302.0
TLS2_k127_5364997_13 NUDIX domain K01823 GO:0003674,GO:0003824,GO:0004452,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0019637,GO:0033554,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046490,GO:0050896,GO:0051716,GO:0071704,GO:0090407,GO:1901576 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000009553 228.0
TLS2_k127_5364997_14 PFAM PspA IM30 family protein K03969 GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000004002 229.0
TLS2_k127_5364997_15 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000002173 224.0
TLS2_k127_5364997_16 receiver - - - 0.0000000000000000000000000000000000000000000000000000003844 210.0
TLS2_k127_5364997_17 GHMP kinases N terminal domain K00938 - 2.7.4.2 0.00000000000000000000000000000000000000000004181 175.0
TLS2_k127_5364997_18 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.0000000000000000000000000000000000000000001391 162.0
TLS2_k127_5364997_19 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000000000000001387 155.0
TLS2_k127_5364997_2 synthase K01641,K15311 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 565.0
TLS2_k127_5364997_20 - K01992 - - 0.00000000000000000000000000003653 129.0
TLS2_k127_5364997_21 PspC domain - - - 0.000000000000000000000702 99.0
TLS2_k127_5364997_22 Type II secretion system protein B K02451 - - 0.000000000000001518 85.0
TLS2_k127_5364997_23 Phage shock protein B K03970 - - 0.00000000002376 66.0
TLS2_k127_5364997_24 Domain of unknown function (DUF4286) - - - 0.00000000005701 75.0
TLS2_k127_5364997_25 PspC domain K03973 - - 0.000000008137 60.0
TLS2_k127_5364997_26 - - - - 0.0000004591 56.0
TLS2_k127_5364997_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 475.0
TLS2_k127_5364997_4 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 442.0
TLS2_k127_5364997_5 sensor diguanylate cyclase phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 443.0
TLS2_k127_5364997_6 (ABC) transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 397.0
TLS2_k127_5364997_7 ATPase associated with various cellular activities, AAA_5 K03974 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005658 398.0
TLS2_k127_5364997_8 abc transporter atp-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 367.0
TLS2_k127_5364997_9 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 345.0
TLS2_k127_5422234_0 Bacterial DNA polymerase III alpha subunit K14162 - 2.7.7.7 0.0 1274.0
TLS2_k127_5422234_1 PFAM Type II secretion system protein E K02454 - - 1.35e-208 660.0
TLS2_k127_5422234_2 secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 551.0
TLS2_k127_5422234_3 General secretion pathway protein K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 427.0
TLS2_k127_5422234_4 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001542 296.0
TLS2_k127_5422234_5 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000005013 271.0
TLS2_k127_5422234_6 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053,K14160 - - 0.000000000000000000000000000000000000000000000006377 181.0
TLS2_k127_5422234_7 Type II secretion system protein C - - - 0.0000000000000000002666 90.0
TLS2_k127_5422234_8 (Lipo)protein - - - 0.0005502 47.0
TLS2_k127_5448184_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 1.128e-291 913.0
TLS2_k127_5448184_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 1.442e-198 631.0
TLS2_k127_5448184_2 PFAM TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000681 588.0
TLS2_k127_5448184_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 590.0
TLS2_k127_5448184_4 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.000000000000000000000000000000000000000000005669 169.0
TLS2_k127_5453048_0 - - - - 0.0 1059.0
TLS2_k127_5453048_1 TonB dependent receptor K02014 - - 1.268e-304 958.0
TLS2_k127_5453048_10 Amino-transferase class IV K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 490.0
TLS2_k127_5453048_11 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006481 471.0
TLS2_k127_5453048_12 Sulfotransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008459 471.0
TLS2_k127_5453048_13 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 453.0
TLS2_k127_5453048_14 PFAM Na H antiporter MnhB subunit-related protein K05566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 429.0
TLS2_k127_5453048_15 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 447.0
TLS2_k127_5453048_16 ABC transporter substrate-binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005855 410.0
TLS2_k127_5453048_17 Signal transduction histidine kinase K07643,K07645 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007154 420.0
TLS2_k127_5453048_18 Sigma factor regulator FecR K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 346.0
TLS2_k127_5453048_19 UTRA K03710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 341.0
TLS2_k127_5453048_2 TonB dependent receptor - - - 3.479e-270 853.0
TLS2_k127_5453048_20 HpcH/HpaI aldolase/citrate lyase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 337.0
TLS2_k127_5453048_21 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 306.0
TLS2_k127_5453048_22 endonuclease activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004525 262.0
TLS2_k127_5453048_23 PFAM NADH-ubiquinone oxidoreductase chain 4L K05567 - - 0.0000000000000000000000000000000000000000000001439 172.0
TLS2_k127_5453048_24 GGDEF domain - - - 0.000000000000000000000000000000000000000006621 174.0
TLS2_k127_5453048_25 peptide ABC transporter substrate-binding protein K07165 - - 0.00000000000000000000000000000000000000001929 167.0
TLS2_k127_5453048_26 PFAM cation antiporter K05569 - - 0.00000000000000000000000000000000000312 142.0
TLS2_k127_5453048_27 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.00000000000000000000000000000000000463 139.0
TLS2_k127_5453048_28 secreted protein - - - 0.00000000000000000000000000006829 124.0
TLS2_k127_5453048_29 PFAM multiple resistance and pH regulation protein F K05570 - - 0.0000000000000000000000000002561 116.0
TLS2_k127_5453048_3 Glycosyl hydrolase family 20, catalytic domain K12373 - 3.2.1.52 1.629e-230 739.0
TLS2_k127_5453048_30 Bacterial OB fold (BOF) protein - - - 0.00000000000000000000000006387 112.0
TLS2_k127_5453048_31 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000002544 92.0
TLS2_k127_5453048_32 Lipid A 3-O-deacylase (PagL) - - - 0.00004146 55.0
TLS2_k127_5453048_4 peptidase - - - 1.149e-229 737.0
TLS2_k127_5453048_5 Proton-conducting membrane transporter K05568 - - 3.156e-206 656.0
TLS2_k127_5453048_6 PTS system, glucose subfamily, IIA K11189 - - 3.45e-203 663.0
TLS2_k127_5453048_7 Phosphotransferase system, EIIC K02803,K02804 - 2.7.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 615.0
TLS2_k127_5453048_8 Trehalase K01194 - 3.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 607.0
TLS2_k127_5453048_9 COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 593.0
TLS2_k127_5525224_0 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 293.0
TLS2_k127_5525224_1 COG3104 Dipeptide tripeptide permease K03305 - - 0.000000000000000000000000000000000000000000000000000000003922 203.0
TLS2_k127_5525224_2 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000000000003015 189.0
TLS2_k127_5525224_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03425 GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000005245 71.0
TLS2_k127_5525224_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000142 68.0
TLS2_k127_5560751_0 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 294.0
TLS2_k127_5560751_1 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002211 280.0
TLS2_k127_5560751_2 Outer membrane protein protective antigen OMA87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009822 249.0
TLS2_k127_5560751_3 Eukaryotic-type carbonic anhydrase K01674 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000006724 237.0
TLS2_k127_5560751_4 Porin subfamily - - - 0.000000000000000000000000000000000000000000000000000001509 208.0
TLS2_k127_5560751_5 long-chain fatty acid transport protein - - - 0.0000000000000000000000000000000000003068 153.0
TLS2_k127_5560751_6 Transcriptional regulator - - - 0.00000000000000001778 94.0
TLS2_k127_5560751_7 protein involved in outer membrane biogenesis K07290 - - 0.00000000807 67.0
TLS2_k127_5560751_8 Protein of unknown function (DUF1214) - - - 0.0000004408 51.0
TLS2_k127_5617964_0 Peptidase M16 - - - 0.0 1095.0
TLS2_k127_5617964_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 1.06e-213 676.0
TLS2_k127_5617964_2 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 555.0
TLS2_k127_5617964_3 PFAM ABC transporter transmembrane region K06021,K13409,K20344 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009637 482.0
TLS2_k127_5617964_4 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 460.0
TLS2_k127_5617964_5 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 362.0
TLS2_k127_5617964_6 - - - - 0.000000000000000000000000000000000000016 152.0
TLS2_k127_5617964_7 - - - - 0.000000000000000000000000000000000005087 145.0
TLS2_k127_5617964_8 Secretion protein K13408 - - 0.00000000000000000000000000000000001893 152.0
TLS2_k127_5622451_0 Acetolactate synthase K01652 - 2.2.1.6 1.013e-293 912.0
TLS2_k127_5622451_1 Isocitrate dehydrogenase - - - 6.747e-221 692.0
TLS2_k127_5622451_10 acetolactate synthase, small K01653 - 2.2.1.6 0.000000000000000000000000000000000000001287 154.0
TLS2_k127_5622451_11 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000001973 143.0
TLS2_k127_5622451_12 Belongs to the ompA family - - - 0.000000000000000000000001889 116.0
TLS2_k127_5622451_13 ABC-type multidrug transport system ATPase component - - - 0.000002616 60.0
TLS2_k127_5622451_2 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 564.0
TLS2_k127_5622451_3 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 466.0
TLS2_k127_5622451_4 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 351.0
TLS2_k127_5622451_5 COG0811 Biopolymer transport proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 314.0
TLS2_k127_5622451_6 Secreted protein, containing von Willebrand factor (VWF) type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 312.0
TLS2_k127_5622451_7 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007785 311.0
TLS2_k127_5622451_8 involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005716 251.0
TLS2_k127_5622451_9 - - - - 0.00000000000000000000000000000000000000000000504 181.0
TLS2_k127_5654075_0 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 535.0
TLS2_k127_5654075_1 negative regulation of protein lipidation K19294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 519.0
TLS2_k127_5654075_10 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008429 254.0
TLS2_k127_5654075_11 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000008022 139.0
TLS2_k127_5654075_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000002424 112.0
TLS2_k127_5654075_13 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.00000000000000000005229 92.0
TLS2_k127_5654075_14 coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000002262 91.0
TLS2_k127_5654075_15 - - - - 0.000000000000005733 87.0
TLS2_k127_5654075_16 Fibronectin type 3 domain - - - 0.000000000002258 77.0
TLS2_k127_5654075_17 - - - - 0.00000000003517 75.0
TLS2_k127_5654075_18 Fibronectin type 3 domain - - - 0.00000002118 64.0
TLS2_k127_5654075_2 Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA K21782 GO:0003674,GO:0003824,GO:0003995,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249,GO:0055114 1.3.8.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008 422.0
TLS2_k127_5654075_3 PFAM ABC transporter related K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 356.0
TLS2_k127_5654075_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 344.0
TLS2_k127_5654075_5 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 310.0
TLS2_k127_5654075_6 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005358 289.0
TLS2_k127_5654075_7 Polysaccharide pyruvyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000858 293.0
TLS2_k127_5654075_8 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000003268 266.0
TLS2_k127_5654075_9 Cupin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001228 258.0
TLS2_k127_5665789_0 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 294.0
TLS2_k127_5665789_1 Belongs to the UPF0178 family K09768 - - 0.0000000000000005317 78.0
TLS2_k127_5665789_2 C-terminal domain of CHU protein family - - - 0.000000009533 64.0
TLS2_k127_5673465_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1008.0
TLS2_k127_5673465_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 7.516e-268 834.0
TLS2_k127_5673465_10 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000006642 223.0
TLS2_k127_5673465_11 MerR family regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000001202 201.0
TLS2_k127_5673465_12 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000000000006569 181.0
TLS2_k127_5673465_13 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000001345 160.0
TLS2_k127_5673465_14 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.0000000000000000000000000000000000000000006031 159.0
TLS2_k127_5673465_15 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000002679 87.0
TLS2_k127_5673465_16 competence protein ComEA K02237 - - 0.00000000000000001548 85.0
TLS2_k127_5673465_17 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000004252 62.0
TLS2_k127_5673465_2 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 6.703e-230 736.0
TLS2_k127_5673465_3 leucine-zipper of insertion element IS481 K07497 - - 1.794e-199 627.0
TLS2_k127_5673465_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009377 526.0
TLS2_k127_5673465_5 COG0436 Aspartate tyrosine aromatic aminotransferase K00812,K12252 - 2.6.1.1,2.6.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 492.0
TLS2_k127_5673465_6 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 438.0
TLS2_k127_5673465_7 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 367.0
TLS2_k127_5673465_8 Transcriptional regulator K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009977 258.0
TLS2_k127_5673465_9 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005455 261.0
TLS2_k127_5677028_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 8.094e-312 974.0
TLS2_k127_5677028_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 533.0
TLS2_k127_5677028_2 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000000000000001016 211.0
TLS2_k127_5677028_3 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000005506 202.0
TLS2_k127_5685344_0 serine-type peptidase activity K01990,K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 511.0
TLS2_k127_5685344_1 ECF sigma factor - - - 0.000000000000000000000000000000000000000003549 161.0
TLS2_k127_5685344_2 Recombinase - - - 0.00000000000002016 80.0
TLS2_k127_5685344_3 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000002326 55.0
TLS2_k127_5726728_0 TonB-dependent receptor - - - 0.0 1170.0
TLS2_k127_5726728_1 COG1472 Beta-glucosidase-related glycosidases K05349 - 3.2.1.21 3.132e-279 885.0
TLS2_k127_5726728_10 - - - - 0.000000000002367 70.0
TLS2_k127_5726728_11 Outer membrane receptor - - - 0.00000000002627 67.0
TLS2_k127_5726728_12 PFAM Proprotein convertase P-domain - - - 0.0000002511 56.0
TLS2_k127_5726728_2 Tryptophan halogenase K14266 - 1.14.19.9 1.972e-229 723.0
TLS2_k127_5726728_3 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000804 608.0
TLS2_k127_5726728_4 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 552.0
TLS2_k127_5726728_5 transcriptional regulator K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 458.0
TLS2_k127_5726728_6 Glycosyl hydrolases family 2, TIM barrel domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 460.0
TLS2_k127_5726728_7 SapC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002173 281.0
TLS2_k127_5726728_8 - - - - 0.00000000000000000004264 93.0
TLS2_k127_5726728_9 Protein of unknown function (DUF3185) - - - 0.000000000000002375 81.0
TLS2_k127_5741740_0 Tryptophan halogenase K14266 - 1.14.19.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 501.0
TLS2_k127_5741740_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 364.0
TLS2_k127_5741740_2 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 376.0
TLS2_k127_5741740_3 Tryptophan halogenase K14266 - 1.14.19.9 0.000000000000000000000000000000000000000000000000000005305 194.0
TLS2_k127_5741740_4 - - - - 0.0000000000000000000000000000000000000000000001495 190.0
TLS2_k127_5741740_6 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.00000000000000000000000018 123.0
TLS2_k127_5741740_7 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000002136 116.0
TLS2_k127_5773111_0 Cellulase N-terminal ig-like domain - - - 0.0 1082.0
TLS2_k127_5773111_1 transcription factor jumonji - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 473.0
TLS2_k127_5773111_2 PFAM SMP-30 Gluconolaconase K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004943 448.0
TLS2_k127_5773111_3 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 352.0
TLS2_k127_5773111_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000004848 205.0
TLS2_k127_5773111_5 Transcription elongation factor, GreA/GreB, C-term K04760 - - 0.000000000000000000000000000000000008768 142.0
TLS2_k127_5773111_6 Domains in Na-Ca exchangers and integrin-beta4 - - - 0.00000000000000000000009006 116.0
TLS2_k127_5781258_0 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 2.806e-263 824.0
TLS2_k127_5781258_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 4.421e-214 670.0
TLS2_k127_5781258_10 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 376.0
TLS2_k127_5781258_11 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008877 373.0
TLS2_k127_5781258_12 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 372.0
TLS2_k127_5781258_13 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 339.0
TLS2_k127_5781258_14 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 338.0
TLS2_k127_5781258_15 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 334.0
TLS2_k127_5781258_16 PFAM LppC K07121 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 328.0
TLS2_k127_5781258_17 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009769 286.0
TLS2_k127_5781258_18 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271,K12961 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007619 273.0
TLS2_k127_5781258_19 PFAM Glutathione S-transferase K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001089 273.0
TLS2_k127_5781258_2 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 621.0
TLS2_k127_5781258_20 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000577 273.0
TLS2_k127_5781258_21 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000000000000000000000000000000001291 215.0
TLS2_k127_5781258_22 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.0000000000000000000000000000000000000000006215 169.0
TLS2_k127_5781258_23 stringent starvation protein b K03600 - - 0.00000000000000000000000000000000006528 138.0
TLS2_k127_5781258_24 LppC putative lipoprotein - - - 0.00000000000000000000000000000002154 128.0
TLS2_k127_5781258_25 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000009797 110.0
TLS2_k127_5781258_26 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000000007389 84.0
TLS2_k127_5781258_3 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 600.0
TLS2_k127_5781258_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 516.0
TLS2_k127_5781258_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 506.0
TLS2_k127_5781258_6 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 453.0
TLS2_k127_5781258_7 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 408.0
TLS2_k127_5781258_8 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 404.0
TLS2_k127_5781258_9 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 396.0
TLS2_k127_5806816_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 9.146e-249 772.0
TLS2_k127_5806816_1 Phospholipase D. Active site motifs. K01115 - 3.1.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 563.0
TLS2_k127_5806816_11 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000001822 61.0
TLS2_k127_5806816_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 392.0
TLS2_k127_5806816_3 Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000003922 200.0
TLS2_k127_5806816_4 COG0515 Serine threonine protein kinase K08282,K11916,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000002223 197.0
TLS2_k127_5806816_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000000000000000000000000000000001394 165.0
TLS2_k127_5806816_6 Protein of unknown function (DUF3618) - - - 0.000000000000000000000000000000000000000006538 166.0
TLS2_k127_5806816_7 17 kDa surface antigen - - - 0.000000000000000000000000000000203 128.0
TLS2_k127_5806816_8 - - - - 0.000000000000000006675 91.0
TLS2_k127_5806816_9 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00000000001211 73.0
TLS2_k127_5807611_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0 1566.0
TLS2_k127_5807611_1 MaoC like domain K02618 - 1.2.1.91,3.3.2.12 2.401e-277 869.0
TLS2_k127_5807611_10 Phytoene dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009236 527.0
TLS2_k127_5807611_11 COG1233 Phytoene dehydrogenase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 502.0
TLS2_k127_5807611_12 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 495.0
TLS2_k127_5807611_13 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007429 459.0
TLS2_k127_5807611_14 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 437.0
TLS2_k127_5807611_15 glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 434.0
TLS2_k127_5807611_16 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00479 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 422.0
TLS2_k127_5807611_17 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 417.0
TLS2_k127_5807611_18 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 417.0
TLS2_k127_5807611_19 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 360.0
TLS2_k127_5807611_2 COG0457 FOG TPR repeat - - - 6.184e-229 721.0
TLS2_k127_5807611_20 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 364.0
TLS2_k127_5807611_21 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 357.0
TLS2_k127_5807611_22 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 334.0
TLS2_k127_5807611_23 Oxidoreductase FAD-binding domain K02613 GO:0000166,GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007501 322.0
TLS2_k127_5807611_24 phenylacetic acid degradation operon negative regulatory protein K02616 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010124,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010817,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019748,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043170,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098754,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007907 316.0
TLS2_k127_5807611_25 phenylacetic acid K02611 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007269 297.0
TLS2_k127_5807611_26 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 286.0
TLS2_k127_5807611_27 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000002216 266.0
TLS2_k127_5807611_28 COG1392 Phosphate transport regulator (distant homolog of PhoU) K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004211 255.0
TLS2_k127_5807611_29 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000005104 246.0
TLS2_k127_5807611_3 Na H antiporter - - - 6.424e-213 680.0
TLS2_k127_5807611_30 universal stress protein K14055 - - 0.0000000000000000000000000000000000000000000000000000000000004261 222.0
TLS2_k127_5807611_31 HlyD family secretion protein K01993 - - 0.0000000000000000000000000000000000000000000000000000000000008677 223.0
TLS2_k127_5807611_32 EVE domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000003887 213.0
TLS2_k127_5807611_33 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000000000000000000000000000000003349 198.0
TLS2_k127_5807611_34 metal-sulfur cluster biosynthetic enzyme K02612 GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000000000000000000000000000000009154 192.0
TLS2_k127_5807611_35 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000000000532 177.0
TLS2_k127_5807611_36 Phenylacetate-CoA oxygenase K02610 GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000001601 158.0
TLS2_k127_5807611_37 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000001057 158.0
TLS2_k127_5807611_38 phenylacetic acid degradation protein K02614 - - 0.000000000000000000000000000000000000002049 152.0
TLS2_k127_5807611_39 Bacterial transcriptional regulator - - - 0.000000000000000000000000000000000000006059 155.0
TLS2_k127_5807611_4 belongs to the aldehyde dehydrogenase family K09472 - 1.2.1.99 4.772e-211 666.0
TLS2_k127_5807611_40 threonine efflux protein - - - 0.0001847 45.0
TLS2_k127_5807611_5 COG1042 Acyl-CoA synthetase (NDP forming) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 605.0
TLS2_k127_5807611_6 catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP K00647 - 2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 589.0
TLS2_k127_5807611_7 Domain of unknown function (DUF4153) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 569.0
TLS2_k127_5807611_8 TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit K02609 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 530.0
TLS2_k127_5807611_9 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 529.0
TLS2_k127_5815793_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1146.0
TLS2_k127_5815793_1 peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007559 289.0
TLS2_k127_5815793_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000001374 205.0
TLS2_k127_5815793_3 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000001682 131.0
TLS2_k127_5815793_4 - - - - 0.0000000000000002231 85.0
TLS2_k127_5863606_0 Methionine synthase K00548 - 2.1.1.13 0.0 1641.0
TLS2_k127_5863606_1 TonB-dependent receptor K02014 - - 0.0 1425.0
TLS2_k127_5863606_10 cystathionine K01758 - 4.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 561.0
TLS2_k127_5863606_11 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 540.0
TLS2_k127_5863606_12 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 518.0
TLS2_k127_5863606_13 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 507.0
TLS2_k127_5863606_14 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 503.0
TLS2_k127_5863606_15 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000907 461.0
TLS2_k127_5863606_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 459.0
TLS2_k127_5863606_17 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 447.0
TLS2_k127_5863606_18 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 449.0
TLS2_k127_5863606_19 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 458.0
TLS2_k127_5863606_2 Carbohydrate phosphorylase K00688 GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 2.5e-323 1008.0
TLS2_k127_5863606_20 Belongs to the peptidase S11 family K07258 GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 412.0
TLS2_k127_5863606_21 FAD binding domain K00486 - 1.14.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 419.0
TLS2_k127_5863606_22 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 396.0
TLS2_k127_5863606_23 FAD dependent oxidoreductase K00285,K21060 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 406.0
TLS2_k127_5863606_24 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 383.0
TLS2_k127_5863606_25 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 366.0
TLS2_k127_5863606_26 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 350.0
TLS2_k127_5863606_27 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 347.0
TLS2_k127_5863606_28 related to Ser Thr protein kinases K07102 GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 340.0
TLS2_k127_5863606_29 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.6.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 316.0
TLS2_k127_5863606_3 Protein of unknown function, DUF255 K06888 - - 2.86e-255 805.0
TLS2_k127_5863606_30 lytic murein transglycosylase B K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001426 296.0
TLS2_k127_5863606_31 3-hydroxyanthranilic acid dioxygenase K00452 - 1.13.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001756 274.0
TLS2_k127_5863606_32 Domain of unknown function (DUF1905) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004349 264.0
TLS2_k127_5863606_33 Cell shape-determining protein K03570 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005676 266.0
TLS2_k127_5863606_34 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000004979 260.0
TLS2_k127_5863606_35 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000000001027 256.0
TLS2_k127_5863606_36 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003279 249.0
TLS2_k127_5863606_37 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000001588 248.0
TLS2_k127_5863606_38 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000000008245 230.0
TLS2_k127_5863606_39 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000001081 228.0
TLS2_k127_5863606_4 alanine symporter K03310 - - 4.125e-235 737.0
TLS2_k127_5863606_40 PFAM Acetyltransferase (GNAT) family K03395 - 2.3.1.60 0.000000000000000000000000000000000000000000000000000000000000000137 225.0
TLS2_k127_5863606_41 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000002557 238.0
TLS2_k127_5863606_42 Uncharacterized protein conserved in bacteria (DUF2200) - - - 0.00000000000000000000000000000000000000000000000000000000000005716 218.0
TLS2_k127_5863606_43 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.0000000000000000000000000000000000000000000000000000000002358 215.0
TLS2_k127_5863606_44 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.000000000000000000000000000000000000000000000000000000006344 217.0
TLS2_k127_5863606_45 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000086 209.0
TLS2_k127_5863606_46 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000002326 213.0
TLS2_k127_5863606_47 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000002481 202.0
TLS2_k127_5863606_48 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000001554 195.0
TLS2_k127_5863606_49 translation initiation inhibitor, yjgF family K15067 - 3.5.99.5 0.000000000000000000000000000000000000000000000000001701 186.0
TLS2_k127_5863606_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.027e-207 655.0
TLS2_k127_5863606_50 PFAM ApaG domain protein K06195 - - 0.000000000000000000000000000000000000000000000000002905 184.0
TLS2_k127_5863606_51 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000000000000000000000000007828 180.0
TLS2_k127_5863606_52 Protein of unknown function (DUF962) - - - 0.0000000000000000000000000000000000000000000003296 170.0
TLS2_k127_5863606_53 Large family of predicted nucleotide-binding domains - - - 0.000000000000000000000000000000000000000001212 159.0
TLS2_k127_5863606_54 Bacterial PH domain K08981 - - 0.0000000000000000000000000000000000001645 160.0
TLS2_k127_5863606_55 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 - - 0.000000000000000000000000000000000001057 151.0
TLS2_k127_5863606_56 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000002796 138.0
TLS2_k127_5863606_57 Cupin domain - - - 0.0000000000000000000000000000000004624 134.0
TLS2_k127_5863606_58 acetyltransferase - - - 0.000000000000000000000000000006211 124.0
TLS2_k127_5863606_59 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - 0.00000000000000000000000000001284 127.0
TLS2_k127_5863606_6 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.409e-204 649.0
TLS2_k127_5863606_60 Protein of unknown function (DUF3775) - - - 0.000000000000000000000000000936 123.0
TLS2_k127_5863606_61 Bacterial PH domain K09167 - - 0.000000000000000000000009207 107.0
TLS2_k127_5863606_62 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000002607 102.0
TLS2_k127_5863606_63 transcriptional regulator K07172 - - 0.000000000000000000000249 100.0
TLS2_k127_5863606_64 - - - - 0.0000000000000000000007743 103.0
TLS2_k127_5863606_66 Belongs to the UPF0250 family K09158 - - 0.000000000000001374 89.0
TLS2_k127_5863606_7 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 2.977e-202 647.0
TLS2_k127_5863606_8 Cystathionine beta-synthase K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 589.0
TLS2_k127_5863606_9 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 569.0
TLS2_k127_5907675_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.308e-290 910.0
TLS2_k127_5907675_1 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 574.0
TLS2_k127_5907675_10 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 344.0
TLS2_k127_5907675_11 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 285.0
TLS2_k127_5907675_12 Conserved hypothetical protein 698 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000108 246.0
TLS2_k127_5907675_13 Belongs to the peptidase S51 family - - - 0.000000000000000000000000000000000000000000001045 177.0
TLS2_k127_5907675_14 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor K00404 - 1.9.3.1 0.0000000000000000000000000000000000004065 143.0
TLS2_k127_5907675_15 Acetyltransferase (GNAT) domain K03817 - - 0.000000000000000000000000000000006089 135.0
TLS2_k127_5907675_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 567.0
TLS2_k127_5907675_3 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007964 552.0
TLS2_k127_5907675_4 Belongs to the glycosyl hydrolase 57 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003881 544.0
TLS2_k127_5907675_5 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 533.0
TLS2_k127_5907675_6 Dehydrogenase K00101 - 1.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 496.0
TLS2_k127_5907675_7 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 453.0
TLS2_k127_5907675_8 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 393.0
TLS2_k127_5907675_9 Putative esterase K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 377.0
TLS2_k127_5911847_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1141.0
TLS2_k127_5911847_1 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002186 259.0
TLS2_k127_5911847_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000001583 161.0
TLS2_k127_5911847_3 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.000000000000000000000000000000000000000004696 161.0
TLS2_k127_5960805_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003088 265.0
TLS2_k127_5960805_1 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000006613 152.0
TLS2_k127_59742_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.647e-276 858.0
TLS2_k127_59742_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 6.971e-250 791.0
TLS2_k127_59742_10 Competence protein - - - 0.0000000000000000000000000000000000000001121 161.0
TLS2_k127_59742_11 SURF1-like protein K14998 - - 0.00000000000000000000000000000000000265 148.0
TLS2_k127_59742_12 signal sequence binding - - - 0.00000000000000000000002111 109.0
TLS2_k127_59742_2 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 394.0
TLS2_k127_59742_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 381.0
TLS2_k127_59742_4 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 332.0
TLS2_k127_59742_5 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 314.0
TLS2_k127_59742_6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.00000000000000000000000000000000000000000000000000000002016 210.0
TLS2_k127_59742_7 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000000313 183.0
TLS2_k127_59742_8 endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000004328 176.0
TLS2_k127_59742_9 cytochrome c oxidase assembly protein K02258 - - 0.00000000000000000000000000000000000000000000003105 178.0
TLS2_k127_5977267_0 Belongs to the ClpA ClpB family K03694 - - 1.457e-321 997.0
TLS2_k127_5977267_1 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000008257 144.0
TLS2_k127_5977267_2 Type II secretion system protein C - - - 0.00000000000000000000000000000003688 136.0
TLS2_k127_5991453_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 7.132e-292 922.0
TLS2_k127_5991453_1 Belongs to the glycosyl hydrolase 13 family K21575 - 3.2.1.135 1.503e-236 746.0
TLS2_k127_5991453_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.000000000000000000000000000000000000000000000004435 177.0
TLS2_k127_5991453_11 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000002212 130.0
TLS2_k127_5991453_12 SnoaL-like domain - - - 0.00000000000000000009916 96.0
TLS2_k127_5991453_2 Tryptophan halogenase K14266 - 1.14.19.9 2.977e-215 678.0
TLS2_k127_5991453_3 PFAM major facilitator superfamily MFS_1 K16211 - - 3.844e-212 676.0
TLS2_k127_5991453_4 alpha amylase, catalytic - - - 1.042e-210 670.0
TLS2_k127_5991453_5 transcriptional K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 419.0
TLS2_k127_5991453_6 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 312.0
TLS2_k127_5991453_7 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007741 308.0
TLS2_k127_5991453_8 CorA-like Mg2+ transporter protein K03284,K16074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001998 287.0
TLS2_k127_5991453_9 Activator of Hsp90 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004357 259.0
TLS2_k127_5992848_0 TonB dependent receptor K02014 - - 1.29e-241 781.0
TLS2_k127_5992848_1 PFAM peptidase M24 K01271 - 3.4.13.9 2.381e-202 638.0
TLS2_k127_5992848_2 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 443.0
TLS2_k127_5992848_3 DNA mediated transformation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 447.0
TLS2_k127_5992848_4 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 293.0
TLS2_k127_5992848_5 Exopolysaccharide synthesis ExoD - - - 0.0000000000000000000000000000000000000000000000000000000000000004882 227.0
TLS2_k127_5992848_6 NIPSNAP - - - 0.0000000000000000000000000000000000000000001393 164.0
TLS2_k127_6017043_0 Succinyl-CoA ligase like flavodoxin domain K09181 - - 0.0 1264.0
TLS2_k127_6017043_1 cation transport ATPase - - - 0.0 1142.0
TLS2_k127_6017043_10 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 607.0
TLS2_k127_6017043_11 Receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 456.0
TLS2_k127_6017043_12 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005717 432.0
TLS2_k127_6017043_13 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 389.0
TLS2_k127_6017043_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 376.0
TLS2_k127_6017043_15 Outer membrane lipoprotein-sorting protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 334.0
TLS2_k127_6017043_16 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 334.0
TLS2_k127_6017043_17 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009181 330.0
TLS2_k127_6017043_18 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 324.0
TLS2_k127_6017043_19 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 308.0
TLS2_k127_6017043_2 Required for chromosome condensation and partitioning K03529 - - 0.0 1094.0
TLS2_k127_6017043_20 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005708 304.0
TLS2_k127_6017043_21 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 314.0
TLS2_k127_6017043_22 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005839 294.0
TLS2_k127_6017043_23 KR domain - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000104 283.0
TLS2_k127_6017043_24 hydrolase of the alpha beta-hydrolase fold K07019 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001622 289.0
TLS2_k127_6017043_25 Belongs to the SUA5 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009784 278.0
TLS2_k127_6017043_26 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000002376 270.0
TLS2_k127_6017043_27 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000251 260.0
TLS2_k127_6017043_28 cytochrome C oxidase K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005992 265.0
TLS2_k127_6017043_29 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.00000000000000000000000000000000000000000000000000000000000000000005216 244.0
TLS2_k127_6017043_3 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1034.0
TLS2_k127_6017043_30 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000691 240.0
TLS2_k127_6017043_31 PIN domain - - - 0.000000000000000000000000000000000000000000000000000000000000002381 223.0
TLS2_k127_6017043_32 Phosphoglycolate phosphatase K22292 - 3.1.3.105 0.00000000000000000000000000000000000000000000000000000000007786 212.0
TLS2_k127_6017043_33 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression K06204 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000032 188.0
TLS2_k127_6017043_34 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000001505 182.0
TLS2_k127_6017043_35 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000001859 174.0
TLS2_k127_6017043_36 sister chromatid segregation - - - 0.00000000000000000000000000000000000000000000372 174.0
TLS2_k127_6017043_37 - - - - 0.0000000000000000000000000000000000000000009384 169.0
TLS2_k127_6017043_38 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000002166 159.0
TLS2_k127_6017043_39 YCII-related domain K05527,K09780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000002128 151.0
TLS2_k127_6017043_4 FtsX-like permease family K02004 - - 1.617e-303 953.0
TLS2_k127_6017043_40 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000000000000000000000000916 150.0
TLS2_k127_6017043_41 sister chromatid segregation - - - 0.00000000000000000000000000000000000047 153.0
TLS2_k127_6017043_42 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000002595 127.0
TLS2_k127_6017043_43 Yip1 domain - - - 0.00000000000000000000000000002262 125.0
TLS2_k127_6017043_44 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000002273 115.0
TLS2_k127_6017043_45 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000000414 113.0
TLS2_k127_6017043_46 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins K03528 - - 0.000000000000000000000001727 111.0
TLS2_k127_6017043_47 Belongs to the BolA IbaG family K05527 - - 0.00000000000000000000005478 103.0
TLS2_k127_6017043_48 synthesis repressor, PhaR - - - 0.00000000000000000000007766 107.0
TLS2_k127_6017043_49 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000006918 109.0
TLS2_k127_6017043_5 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.738e-302 948.0
TLS2_k127_6017043_50 Methyltransferase domain - - - 0.000000000000000003987 94.0
TLS2_k127_6017043_51 SnoaL-like domain - - - 0.00006941 51.0
TLS2_k127_6017043_6 Sterol-sensing domain of SREBP cleavage-activation K07003 - - 5.193e-291 914.0
TLS2_k127_6017043_7 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 5.482e-255 804.0
TLS2_k127_6017043_8 efflux transmembrane transporter activity - - - 2.684e-231 742.0
TLS2_k127_6017043_9 Participates in both transcription termination and antitermination K02600 - - 1.862e-222 699.0
TLS2_k127_6034499_0 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 622.0
TLS2_k127_6034499_1 beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 316.0
TLS2_k127_6034499_2 OmpA-like transmembrane domain - - - 0.000000000000000000002851 102.0
TLS2_k127_6034499_3 Methionine biosynthesis protein MetW - - - 0.0001627 48.0
TLS2_k127_6050294_0 Cytochrome C and Quinol oxidase polypeptide I K04561 - 1.7.2.5 4.305e-266 822.0
TLS2_k127_6050294_1 sorbosone dehydrogenase - - - 9.227e-231 728.0
TLS2_k127_6050294_10 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000766 373.0
TLS2_k127_6050294_11 Belongs to the mandelate racemase muconate lactonizing enzyme family K19802 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 362.0
TLS2_k127_6050294_12 Zn-dependent protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 361.0
TLS2_k127_6050294_13 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 351.0
TLS2_k127_6050294_14 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 307.0
TLS2_k127_6050294_15 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 304.0
TLS2_k127_6050294_16 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 317.0
TLS2_k127_6050294_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006222 282.0
TLS2_k127_6050294_18 HAD superfamily, subfamily IIIB (Acid phosphatase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001151 280.0
TLS2_k127_6050294_19 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001624 283.0
TLS2_k127_6050294_2 Nitric oxide reductase activation protein K02448 - - 2.178e-226 720.0
TLS2_k127_6050294_20 Extradiol ring-cleavage dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000017 273.0
TLS2_k127_6050294_21 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000001793 243.0
TLS2_k127_6050294_22 PFAM MOSC domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000009516 241.0
TLS2_k127_6050294_24 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003702 229.0
TLS2_k127_6050294_25 Putative general bacterial porin - - - 0.00000000000000000000000000000000000000000000000000000000000001274 226.0
TLS2_k127_6050294_26 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000004952 208.0
TLS2_k127_6050294_27 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.0000000000000000000000000000000000000000000000000000000005948 208.0
TLS2_k127_6050294_28 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000098 202.0
TLS2_k127_6050294_29 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000000000000000000000000008538 200.0
TLS2_k127_6050294_3 PQQ enzyme repeat K00117 - 1.1.5.2 1.266e-214 694.0
TLS2_k127_6050294_30 membrane - - - 0.00000000000000000000000000000000000000000000000000008251 190.0
TLS2_k127_6050294_31 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000002962 188.0
TLS2_k127_6050294_32 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000000000000001599 167.0
TLS2_k127_6050294_33 - - - - 0.0000000000000000000000000000000000000009613 151.0
TLS2_k127_6050294_34 - - - - 0.00000000000000000000000000000000001328 140.0
TLS2_k127_6050294_35 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000000000000005559 133.0
TLS2_k127_6050294_36 - - - - 0.0000000000000000000000000000002768 131.0
TLS2_k127_6050294_37 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000004607 129.0
TLS2_k127_6050294_38 PIN domain - - - 0.000000000000000000000000000001675 124.0
TLS2_k127_6050294_39 MOSC domain K07140 - - 0.000000000000000000000000002664 118.0
TLS2_k127_6050294_4 RESPONSE REGULATOR receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 562.0
TLS2_k127_6050294_40 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000006193 117.0
TLS2_k127_6050294_41 Protein of unknown function (DUF4019) - - - 0.0000000000000000000000000133 118.0
TLS2_k127_6050294_42 Uncharacterized protein conserved in bacteria (DUF2200) - - - 0.00000000000000000000002387 102.0
TLS2_k127_6050294_43 Pfam:HipA_N - - - 0.000000000000000000000141 102.0
TLS2_k127_6050294_44 - - GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - 0.00000000000000000008906 91.0
TLS2_k127_6050294_46 Type III secretion system lipoprotein chaperone (YscW) K09914 - - 0.00000000000002615 83.0
TLS2_k127_6050294_48 - - - - 0.00000000001337 76.0
TLS2_k127_6050294_49 - - - - 0.00000004681 63.0
TLS2_k127_6050294_5 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 557.0
TLS2_k127_6050294_50 serine threonine-protein kinase K08836,K08837 GO:0000132,GO:0000226,GO:0000278,GO:0000281,GO:0000902,GO:0000910,GO:0001775,GO:0001932,GO:0001934,GO:0001952,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002682,GO:0002685,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005819,GO:0005856,GO:0005886,GO:0005938,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006950,GO:0006955,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007052,GO:0007088,GO:0007091,GO:0007154,GO:0007155,GO:0007159,GO:0007163,GO:0007165,GO:0007346,GO:0008150,GO:0008152,GO:0008283,GO:0009653,GO:0009893,GO:0009987,GO:0010033,GO:0010562,GO:0010564,GO:0010604,GO:0010638,GO:0010799,GO:0010800,GO:0010810,GO:0010941,GO:0010942,GO:0010965,GO:0012505,GO:0012506,GO:0015630,GO:0016020,GO:0016043,GO:0016192,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019220,GO:0019222,GO:0019538,GO:0022402,GO:0022610,GO:0023014,GO:0023052,GO:0030010,GO:0030029,GO:0030036,GO:0030141,GO:0030155,GO:0030334,GO:0030659,GO:0030667,GO:0030865,GO:0030866,GO:0031056,GO:0031058,GO:0031090,GO:0031098,GO:0031122,GO:0031252,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031410,GO:0031982,GO:0032147,GO:0032153,GO:0032154,GO:0032155,GO:0032268,GO:0032270,GO:0032502,GO:0032879,GO:0032940,GO:0032989,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0033127,GO:0033129,GO:0033554,GO:0033674,GO:0034097,GO:0034612,GO:0035556,GO:0035579,GO:0036211,GO:0036230,GO:0040001,GO:0040012,GO:0042119,GO:0042221,GO:0042325,GO:0042327,GO:0042581,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043299,GO:0043312,GO:0043412,GO:0043549,GO:0044087,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044770,GO:0044772,GO:0044784,GO:0045055,GO:0045321,GO:0045859,GO:0045860,GO:0045937,GO:0046777,GO:0046903,GO:0046983,GO:0048471,GO:0048518,GO:0048522,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051233,GO:0051234,GO:0051246,GO:0051247,GO:0051270,GO:0051293,GO:0051294,GO:0051301,GO:0051338,GO:0051347,GO:0051640,GO:0051641,GO:0051649,GO:0051653,GO:0051656,GO:0051716,GO:0051726,GO:0051783,GO:0051893,GO:0051983,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0070486,GO:0070887,GO:0071310,GO:0071345,GO:0071356,GO:0071593,GO:0071704,GO:0071840,GO:0071944,GO:0072686,GO:0080090,GO:0090109,GO:0097435,GO:0097708,GO:0098588,GO:0098590,GO:0098609,GO:0098805,GO:0099503,GO:0099568,GO:0140096,GO:1901564,GO:1901888,GO:1902275,GO:1902850,GO:1903047,GO:1903391,GO:1905269,GO:1905818,GO:1990023,GO:2000145,GO:2000401,GO:2001252 2.7.11.1 0.0000006275 54.0
TLS2_k127_6050294_51 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00009995 54.0
TLS2_k127_6050294_52 Protein kinase domain K12132 - 2.7.11.1 0.0001427 48.0
TLS2_k127_6050294_6 PFAM ATPase associated with various cellular activities K04748 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004719 450.0
TLS2_k127_6050294_7 Mechanosensitive ion channel K16053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 423.0
TLS2_k127_6050294_8 COG2010 Cytochrome c, mono- and diheme variants K02305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 406.0
TLS2_k127_6050294_9 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 376.0
TLS2_k127_6090394_0 Polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008479 483.0
TLS2_k127_6090394_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000000000000000000000000000001637 191.0
TLS2_k127_6090394_2 OHCU decarboxylase - - - 0.000000000000000000000000000000000000000005498 162.0
TLS2_k127_6090394_3 Allantoicase repeat K01477 - 3.5.3.4 0.000000000000000000000000004501 111.0
TLS2_k127_6090394_4 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000000001587 78.0
TLS2_k127_6090394_5 Urate oxidase N-terminal - - - 0.0000000000001418 72.0
TLS2_k127_612171_0 PFAM Tannase and feruloyl esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 502.0
TLS2_k127_612171_1 Membrane-bound lytic murein transglycosylase B K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 488.0
TLS2_k127_612171_10 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 313.0
TLS2_k127_612171_11 Phosphate-selective porin O and P K07221 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000172 286.0
TLS2_k127_612171_12 Domain of unknown function (DUF4974) K07165 - - 0.00000000000000000000000000000000000000000000000000000000000000000001241 253.0
TLS2_k127_612171_13 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000001543 233.0
TLS2_k127_612171_14 - - - - 0.000000000000000000000000000000000000000000000000506 183.0
TLS2_k127_612171_15 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog K03088 - - 0.00000000000000000000000000000000000000003078 160.0
TLS2_k127_612171_16 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000002568 123.0
TLS2_k127_612171_17 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000005824 94.0
TLS2_k127_612171_18 FAD linked oxidase domain protein - - - 0.000000000000004033 79.0
TLS2_k127_612171_2 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009616 498.0
TLS2_k127_612171_3 Bacterial extracellular solute-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 453.0
TLS2_k127_612171_4 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 416.0
TLS2_k127_612171_5 ATPase activity K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 404.0
TLS2_k127_612171_6 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 419.0
TLS2_k127_612171_7 Sulfate ABC transporter, inner membrane subunit CysW K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 357.0
TLS2_k127_612171_8 Sulfate ABC transporter inner membrane subunit CysT K02046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 341.0
TLS2_k127_612171_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 309.0
TLS2_k127_6148702_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 1.231e-280 877.0
TLS2_k127_6148702_1 Helicase K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 589.0
TLS2_k127_6148702_10 PFAM GTP-binding signal recognition particle SRP54 G- domain K02404 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004216 289.0
TLS2_k127_6148702_11 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000143 273.0
TLS2_k127_6148702_12 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002358 270.0
TLS2_k127_6148702_13 Flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008537 249.0
TLS2_k127_6148702_14 Role in flagellar biosynthesis K02421 - - 0.0000000000000000000000000000000000000000000000000000000000007704 218.0
TLS2_k127_6148702_15 Putative porin - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000656 195.0
TLS2_k127_6148702_16 Disulfide bond formation protein DsbB - - - 0.0000000000000000000000000000000000000000000000004615 180.0
TLS2_k127_6148702_17 PFAM Flagellar assembly protein FliH K02411 - - 0.0000000000000000000000000000000000000000000002909 175.0
TLS2_k127_6148702_18 TIGRFAM Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000007215 182.0
TLS2_k127_6148702_19 Universal bacterial protein YeaZ K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 - 0.000000000000000000000000000000000000002051 159.0
TLS2_k127_6148702_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 594.0
TLS2_k127_6148702_20 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.00000000000000000000000000000000002991 147.0
TLS2_k127_6148702_21 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 - - 0.00000000000000000000000000007835 119.0
TLS2_k127_6148702_22 Role in flagellar biosynthesis K02420 - - 0.0000000000000000000000000005813 115.0
TLS2_k127_6148702_23 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.00000000000000000000002242 106.0
TLS2_k127_6148702_24 PFAM Flagellar hook-length control protein K02414 - - 0.00000000000000000005052 104.0
TLS2_k127_6148702_25 Flagellar biosynthesis protein, FliO K02418 - - 0.000000000000001323 84.0
TLS2_k127_6148702_26 PilZ domain - - - 0.00000000003807 72.0
TLS2_k127_6148702_27 flagellar K02413 - - 0.0000000001456 68.0
TLS2_k127_6148702_28 chemotaxis, protein - - - 0.0000009415 57.0
TLS2_k127_6148702_29 sigma54 specific, transcriptional regulator, Fis family K10941 - - 0.000009652 51.0
TLS2_k127_6148702_3 COG1157 Flagellar biosynthesis type III secretory pathway ATPase K02412 GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 571.0
TLS2_k127_6148702_30 Apolipoprotein B receptor - GO:0003674,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006810,GO:0006897,GO:0006898,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016192,GO:0030228,GO:0030229,GO:0032501,GO:0034381,GO:0034447,GO:0038024,GO:0044237,GO:0044238,GO:0044255,GO:0044464,GO:0046486,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071704,GO:0071944,GO:0097006,GO:0098657 - 0.0002798 45.0
TLS2_k127_6148702_4 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 468.0
TLS2_k127_6148702_5 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 373.0
TLS2_k127_6148702_6 sigma54 specific, transcriptional regulator, Fis family K10941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 362.0
TLS2_k127_6148702_7 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 338.0
TLS2_k127_6148702_8 MotA/TolQ/ExbB proton channel family K02556 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 316.0
TLS2_k127_6148702_9 Belongs to the ParA family K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008958 284.0
TLS2_k127_6150538_0 Pro-apoptotic serine protease - - - 7.244e-246 792.0
TLS2_k127_6150538_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 9.005e-235 739.0
TLS2_k127_6150538_10 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000007776 172.0
TLS2_k127_6150538_2 Bacterial protein of unknown function (DUF885) - - - 5.114e-213 679.0
TLS2_k127_6150538_3 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 577.0
TLS2_k127_6150538_4 7 transmembrane helices usually fused to an inactive transglutaminase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 487.0
TLS2_k127_6150538_5 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 479.0
TLS2_k127_6150538_6 TIGRFAM alpha-L-glutamate ligase-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 385.0
TLS2_k127_6150538_7 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K18800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002885 255.0
TLS2_k127_6150538_8 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000002266 194.0
TLS2_k127_6150538_9 Glutathione-dependent formaldehyde-activating GFA - - - 0.000000000000000000000000000000000000000000000002204 176.0
TLS2_k127_6155482_0 COG0457 FOG TPR repeat - - - 1.724e-232 753.0
TLS2_k127_6155482_1 phosphoribosylamine-glycine ligase activity K01945,K01955 - 6.3.4.13,6.3.5.5 2.804e-204 642.0
TLS2_k127_6155482_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 379.0
TLS2_k127_6155482_11 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 357.0
TLS2_k127_6155482_12 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006951 307.0
TLS2_k127_6155482_13 PAS domain K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009228 288.0
TLS2_k127_6155482_14 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000009644 202.0
TLS2_k127_6155482_15 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000003026 216.0
TLS2_k127_6155482_16 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000001384 215.0
TLS2_k127_6155482_17 universal stress protein K14055 - - 0.0000000000000000000000000000000000000000000000000000984 198.0
TLS2_k127_6155482_18 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.0000000000000000000001058 98.0
TLS2_k127_6155482_19 EF-hand domain pair - - - 0.00000000006788 66.0
TLS2_k127_6155482_2 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 6.267e-202 648.0
TLS2_k127_6155482_3 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 580.0
TLS2_k127_6155482_4 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 533.0
TLS2_k127_6155482_5 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 535.0
TLS2_k127_6155482_6 DoxX-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 466.0
TLS2_k127_6155482_7 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K21053 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000662 434.0
TLS2_k127_6155482_8 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 433.0
TLS2_k127_6155482_9 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 417.0
TLS2_k127_6175401_0 DNA helicase K03654 - 3.6.4.12 3.455e-243 775.0
TLS2_k127_6175401_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 324.0
TLS2_k127_6175401_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 329.0
TLS2_k127_6175401_3 RarD protein K05786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 323.0
TLS2_k127_6175401_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001592 270.0
TLS2_k127_6175401_5 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000001526 220.0
TLS2_k127_6175401_6 Domain of unknown function (DUF1993) K09983 - - 0.0000000000000000000000000000000000000000000000000000001149 201.0
TLS2_k127_6175401_7 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000006825 53.0
TLS2_k127_6195057_0 Amidohydrolase family - - - 3.43e-237 746.0
TLS2_k127_6195057_1 receptor - - - 1.151e-206 661.0
TLS2_k127_6195057_2 Beta-L-arabinofuranosidase, GH127 K09955 - - 0.000000000000000000000000000000000000000003391 160.0
TLS2_k127_619565_0 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 572.0
TLS2_k127_619565_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006668 281.0
TLS2_k127_619565_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001444 287.0
TLS2_k127_619565_3 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000007197 249.0
TLS2_k127_619565_4 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.000000000000000000000000000000000000000003329 156.0
TLS2_k127_6312080_0 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 485.0
TLS2_k127_6312080_1 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 308.0
TLS2_k127_6312080_2 Serine aminopeptidase, S33 - - - 0.000000000006979 68.0
TLS2_k127_6345003_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.474e-301 936.0
TLS2_k127_6345003_1 TIGRFAM glutaminyl-tRNA synthetase K01886 - 6.1.1.18 4.273e-234 737.0
TLS2_k127_6345003_10 MoaC family K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000007587 198.0
TLS2_k127_6345003_11 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000002078 183.0
TLS2_k127_6345003_12 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000002795 179.0
TLS2_k127_6345003_13 Belongs to the Fur family K09823 - - 0.00000000000000000000000000000000000000000000000399 197.0
TLS2_k127_6345003_14 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase - - - 0.0000000000000000000000000000000000000000000002798 175.0
TLS2_k127_6345003_15 Belongs to the glycosyl hydrolase 2 family K01195 GO:0003674,GO:0003824,GO:0004553,GO:0004566,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016054,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0019389,GO:0019391,GO:0019752,GO:0022607,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658 3.2.1.31 0.00000000000000000000000000000000000000000001555 162.0
TLS2_k127_6345003_16 cheY-homologous receiver domain - - - 0.000000000000000000000000198 124.0
TLS2_k127_6345003_17 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000002 94.0
TLS2_k127_6345003_18 Molybdopterin K03636 - - 0.0000000000000009818 83.0
TLS2_k127_6345003_2 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 529.0
TLS2_k127_6345003_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 401.0
TLS2_k127_6345003_4 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 378.0
TLS2_k127_6345003_5 Acyl-CoA dehydrogenase, middle domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004681 379.0
TLS2_k127_6345003_6 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 360.0
TLS2_k127_6345003_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000003183 241.0
TLS2_k127_6345003_8 XdhC and CoxI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000008826 247.0
TLS2_k127_6345003_9 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000003811 220.0
TLS2_k127_6402334_0 Maltogenic Amylase, C-terminal domain K01187 - 3.2.1.20 2.897e-220 692.0
TLS2_k127_6495194_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 2.887e-286 899.0
TLS2_k127_6495194_1 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005593 578.0
TLS2_k127_6495194_10 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000000000000000000000000000000000000000001251 169.0
TLS2_k127_6495194_11 cheY-homologous receiver domain - - - 0.000000000000000000000453 112.0
TLS2_k127_6495194_12 VanZ like family - - - 0.000000003467 63.0
TLS2_k127_6495194_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 571.0
TLS2_k127_6495194_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 505.0
TLS2_k127_6495194_4 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 453.0
TLS2_k127_6495194_5 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000715 406.0
TLS2_k127_6495194_6 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007045 380.0
TLS2_k127_6495194_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 306.0
TLS2_k127_6495194_8 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000004035 263.0
TLS2_k127_6495194_9 Belongs to the BI1 family K06890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001606 249.0
TLS2_k127_6510254_0 TonB dependent receptor - - - 1.739e-265 845.0
TLS2_k127_6510254_1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00366,K00381,K00392 GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363 1.7.7.1,1.8.1.2,1.8.7.1 3.384e-228 719.0
TLS2_k127_6510254_10 Belongs to the PAPS reductase family. CysH subfamily K00390 GO:0000103,GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019379,GO:0019419,GO:0044237,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 321.0
TLS2_k127_6510254_11 KaiB K08481 - - 0.00000000000000000000000000000000004367 138.0
TLS2_k127_6510254_2 Pfam:KaiC K08482 - - 7.632e-215 682.0
TLS2_k127_6510254_3 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component K00380 - 1.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 524.0
TLS2_k127_6510254_4 Glycosyl hydrolases family 43 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 496.0
TLS2_k127_6510254_5 Bacterial regulatory helix-turn-helix protein, lysR family K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 387.0
TLS2_k127_6510254_6 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 397.0
TLS2_k127_6510254_7 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 398.0
TLS2_k127_6510254_8 Glutaredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 343.0
TLS2_k127_6510254_9 Transcriptional regulator K13634 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 333.0
TLS2_k127_6550389_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 1.472e-291 920.0
TLS2_k127_6550389_1 Methionine aminopeptidase K01265 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 407.0
TLS2_k127_6550389_2 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 383.0
TLS2_k127_6550389_3 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002293 284.0
TLS2_k127_6550389_4 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000001047 184.0
TLS2_k127_6550389_5 Belongs to the ArsC family - - - 0.000000000000000000000000000000000008365 139.0
TLS2_k127_6551865_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1264.0
TLS2_k127_6551865_1 PGAP1-like protein - - - 8.943e-274 848.0
TLS2_k127_6551865_10 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 439.0
TLS2_k127_6551865_11 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 436.0
TLS2_k127_6551865_12 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 374.0
TLS2_k127_6551865_13 COG2367 Beta-lactamase class A K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006357 364.0
TLS2_k127_6551865_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 318.0
TLS2_k127_6551865_15 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 296.0
TLS2_k127_6551865_16 PFAM Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007854 287.0
TLS2_k127_6551865_17 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000006636 257.0
TLS2_k127_6551865_18 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004762 243.0
TLS2_k127_6551865_19 M61 glycyl aminopeptidase - - - 0.00000000000000000000000004059 115.0
TLS2_k127_6551865_2 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - 2.214e-211 671.0
TLS2_k127_6551865_20 PRC-barrel domain - - - 0.00005494 51.0
TLS2_k127_6551865_3 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 1.395e-202 649.0
TLS2_k127_6551865_4 (ABC) transporter, permease K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 610.0
TLS2_k127_6551865_5 C4-dicarboxylate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 586.0
TLS2_k127_6551865_6 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 573.0
TLS2_k127_6551865_7 COG0339 Zn-dependent oligopeptidases K01284 GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 494.0
TLS2_k127_6551865_8 membrane K07148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 426.0
TLS2_k127_6551865_9 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 424.0
TLS2_k127_6585379_0 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004738 472.0
TLS2_k127_6585379_1 UPF0126 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009521 263.0
TLS2_k127_6585379_2 YaeQ - - - 0.0000000000000000000000000000000000003962 141.0
TLS2_k127_6585379_3 Rnk N-terminus K06140 - - 0.000000000000000000000000000000003706 136.0
TLS2_k127_6585379_4 - - - - 0.00000000001989 65.0
TLS2_k127_6623087_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1045.0
TLS2_k127_6623087_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 2.127e-217 691.0
TLS2_k127_6623087_10 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 424.0
TLS2_k127_6623087_11 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 331.0
TLS2_k127_6623087_12 overlaps another CDS with the same product name - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 308.0
TLS2_k127_6623087_13 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005903 286.0
TLS2_k127_6623087_14 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000157 278.0
TLS2_k127_6623087_15 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004946 274.0
TLS2_k127_6623087_16 endonuclease activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007131 261.0
TLS2_k127_6623087_17 pfkB family carbohydrate kinase K16328 - 2.7.1.83 0.000000000000000000000000000000000000000000000000000000007458 210.0
TLS2_k127_6623087_18 - - - - 0.00000000000000000000000000000000000000000000000000000007367 207.0
TLS2_k127_6623087_19 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000213 203.0
TLS2_k127_6623087_2 oxidase subunit K00425 - 1.10.3.14 1.552e-206 651.0
TLS2_k127_6623087_20 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000000000000008096 196.0
TLS2_k127_6623087_21 Domain of unknown function (DUF4281) - - - 0.000000000000000000000000000000000000000003923 160.0
TLS2_k127_6623087_22 Domain of unknown function (DUF4389) - - - 0.0000000000000000000001767 106.0
TLS2_k127_6623087_23 - - - - 0.000000000000000000003413 98.0
TLS2_k127_6623087_25 COGs COG5616 integral membrane protein - - - 0.00000000008205 72.0
TLS2_k127_6623087_26 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000001689 67.0
TLS2_k127_6623087_27 - - - - 0.0000001547 53.0
TLS2_k127_6623087_28 Ribosomal protein L7/L12 C-terminal domain - - - 0.000001563 54.0
TLS2_k127_6623087_3 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 610.0
TLS2_k127_6623087_4 PQQ-like domain K00114,K17760 - 1.1.2.8,1.1.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 548.0
TLS2_k127_6623087_5 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003012 514.0
TLS2_k127_6623087_6 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 472.0
TLS2_k127_6623087_7 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000351 474.0
TLS2_k127_6623087_8 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 470.0
TLS2_k127_6623087_9 oxidase, subunit K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 447.0
TLS2_k127_6647046_0 TonB-dependent receptor - - - 1.303e-205 675.0
TLS2_k127_6647046_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.205e-203 640.0
TLS2_k127_6647046_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 381.0
TLS2_k127_6647046_11 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 372.0
TLS2_k127_6647046_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 368.0
TLS2_k127_6647046_13 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009015 326.0
TLS2_k127_6647046_14 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 323.0
TLS2_k127_6647046_15 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07663 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 318.0
TLS2_k127_6647046_16 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 317.0
TLS2_k127_6647046_17 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008789 296.0
TLS2_k127_6647046_18 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002554 276.0
TLS2_k127_6647046_19 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002211 270.0
TLS2_k127_6647046_2 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 3.712e-196 626.0
TLS2_k127_6647046_20 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001132 259.0
TLS2_k127_6647046_21 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000005958 263.0
TLS2_k127_6647046_22 protein conserved in bacteria K09797 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000153 256.0
TLS2_k127_6647046_23 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000001641 247.0
TLS2_k127_6647046_24 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000517 237.0
TLS2_k127_6647046_25 Belongs to the Nudix hydrolase family K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000001665 234.0
TLS2_k127_6647046_26 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000186 232.0
TLS2_k127_6647046_27 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000007432 208.0
TLS2_k127_6647046_28 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000006025 194.0
TLS2_k127_6647046_29 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000000000000000000000000000009096 196.0
TLS2_k127_6647046_3 Acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 609.0
TLS2_k127_6647046_30 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000003638 177.0
TLS2_k127_6647046_31 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000001451 164.0
TLS2_k127_6647046_32 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000003888 134.0
TLS2_k127_6647046_33 Protein of unknown function (DUF3465) - - - 0.000000000000000000000000000000001131 134.0
TLS2_k127_6647046_34 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.00000000000000000000000000000001251 139.0
TLS2_k127_6647046_35 Sterol-binding domain protein K03690 - - 0.000000000000000000000000000001178 128.0
TLS2_k127_6647046_36 there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc K02913 - - 0.0000000000000000000002504 96.0
TLS2_k127_6647046_37 Protein of unknown function (DUF962) - - - 0.000000000000000000001893 102.0
TLS2_k127_6647046_38 - - - - 0.0000000000000000001055 92.0
TLS2_k127_6647046_39 Domain of unknown function (DUF4124) - - - 0.00000000000000008218 89.0
TLS2_k127_6647046_4 Acetyl-coenzyme A transporter 1 K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 515.0
TLS2_k127_6647046_5 oxidoreductase activity K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 524.0
TLS2_k127_6647046_6 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 472.0
TLS2_k127_6647046_7 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 438.0
TLS2_k127_6647046_8 COG0534 Na -driven multidrug efflux pump - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 402.0
TLS2_k127_6647046_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009112 406.0
TLS2_k127_6716798_0 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 529.0
TLS2_k127_6716798_1 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 498.0
TLS2_k127_6716798_2 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000005535 227.0
TLS2_k127_6716798_3 UPF0391 membrane protein - - - 0.0000000000000001362 84.0
TLS2_k127_6737267_0 Dehydrogenase K00114 - 1.1.2.8 0.0 1017.0
TLS2_k127_6737267_1 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 431.0
TLS2_k127_6737267_10 Cytochrome c mono- and diheme variants - - - 0.00000000000000000000000000000001117 133.0
TLS2_k127_6737267_11 - - - - 0.00000000000000000003006 104.0
TLS2_k127_6737267_12 - K16258 - - 0.00000000000000001356 92.0
TLS2_k127_6737267_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008753 282.0
TLS2_k127_6737267_3 SMART extracellular solute-binding protein, family 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006947 281.0
TLS2_k127_6737267_4 von Willebrand factor (vWF) type A domain K16257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007573 257.0
TLS2_k127_6737267_5 PFAM Sulphur oxidation protein SoxZ K17226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001028 252.0
TLS2_k127_6737267_6 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000002461 233.0
TLS2_k127_6737267_7 von Willebrand factor (vWF) type A domain K16259 - - 0.0000000000000000000000000000000000000000000000000000000000000003718 234.0
TLS2_k127_6737267_8 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000001451 216.0
TLS2_k127_6737267_9 - K16256 - - 0.000000000000000000000000000000000001533 152.0
TLS2_k127_6760250_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1275.0
TLS2_k127_6760250_1 Diguanylate cyclase - - - 1.806e-201 657.0
TLS2_k127_6760250_10 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000777 265.0
TLS2_k127_6760250_11 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000000000000000000000008739 235.0
TLS2_k127_6760250_12 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000003371 228.0
TLS2_k127_6760250_13 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000001837 154.0
TLS2_k127_6760250_14 - - - - 0.00000000000000000000000005171 113.0
TLS2_k127_6760250_15 DnaK suppressor protein K06204 - - 0.000000000000000000000000143 110.0
TLS2_k127_6760250_16 Methyltransferase domain - - - 0.0000000000000000000000003726 109.0
TLS2_k127_6760250_17 Methyltransferase domain - - - 0.0000000000000000001219 93.0
TLS2_k127_6760250_18 Fe-S protein K06938 - - 0.000000002674 60.0
TLS2_k127_6760250_19 bacterial OsmY and nodulation domain K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.0000009244 56.0
TLS2_k127_6760250_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009736 505.0
TLS2_k127_6760250_3 chaperone-mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 492.0
TLS2_k127_6760250_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 428.0
TLS2_k127_6760250_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 396.0
TLS2_k127_6760250_6 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 347.0
TLS2_k127_6760250_7 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 313.0
TLS2_k127_6760250_8 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 300.0
TLS2_k127_6760250_9 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis K03683 GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002357 282.0
TLS2_k127_6790042_0 Cytochrome c-type biogenesis protein CcmF C-terminal - - - 3.949e-242 766.0
TLS2_k127_6790042_1 Alpha-amylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 522.0
TLS2_k127_6790042_10 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.0000000000000000009571 94.0
TLS2_k127_6790042_11 Forkhead associated domain - - - 0.00000000000001666 86.0
TLS2_k127_6790042_12 SMART AAA ATPase K02450 - - 0.00000002357 66.0
TLS2_k127_6790042_13 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.000005945 49.0
TLS2_k127_6790042_2 Chromate K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 516.0
TLS2_k127_6790042_3 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 329.0
TLS2_k127_6790042_4 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 313.0
TLS2_k127_6790042_5 thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007547 281.0
TLS2_k127_6790042_6 PFAM alpha amylase, catalytic K05343 GO:0000023,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0005991,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009311,GO:0009987,GO:0015980,GO:0016160,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0046872,GO:0047471,GO:0055114,GO:0071704 3.2.1.1,5.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000009291 254.0
TLS2_k127_6790042_7 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000003023 228.0
TLS2_k127_6790042_8 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678 - 0.00000000000000000000000000000000000000001701 162.0
TLS2_k127_6790042_9 COG0526 Thiol-disulfide isomerase and thioredoxins K02199 - - 0.000000000000000000000000000000000003804 146.0
TLS2_k127_6812832_0 Efflux pump membrane transporter K03296,K18138 - - 0.0 1256.0
TLS2_k127_6812832_1 Amidohydrolase K07045 - - 7.525e-217 682.0
TLS2_k127_6812832_10 fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 382.0
TLS2_k127_6812832_11 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 323.0
TLS2_k127_6812832_12 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 312.0
TLS2_k127_6812832_13 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000009563 256.0
TLS2_k127_6812832_14 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006766 245.0
TLS2_k127_6812832_15 PFAM Ribonuclease BN-like family K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000156 247.0
TLS2_k127_6812832_16 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000002298 209.0
TLS2_k127_6812832_17 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000000000000009484 206.0
TLS2_k127_6812832_18 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000114 209.0
TLS2_k127_6812832_19 PFAM ATP-binding region, ATPase-like histidine kinase A-like - - - 0.000000000000000000000000000000000000000000007871 182.0
TLS2_k127_6812832_2 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 1.496e-209 678.0
TLS2_k127_6812832_20 diguanylate cyclase - - - 0.000000000000000000000000000000000000000006032 168.0
TLS2_k127_6812832_21 Proteolipid membrane potential modulator - - - 0.00000000000000000000324 94.0
TLS2_k127_6812832_22 periplasmic or secreted lipoprotein - - - 0.00000000000000000004083 102.0
TLS2_k127_6812832_23 PFAM PRC-barrel domain protein - - - 0.000000000000000002705 91.0
TLS2_k127_6812832_24 UPF0391 membrane protein - - - 0.00000000000000005256 84.0
TLS2_k127_6812832_25 PRC-barrel domain - - - 0.000000000000007433 81.0
TLS2_k127_6812832_27 - - - - 0.0000001551 58.0
TLS2_k127_6812832_28 Protein of unknown function (DUF1328) - - - 0.0000002157 54.0
TLS2_k127_6812832_3 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007677 591.0
TLS2_k127_6812832_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 531.0
TLS2_k127_6812832_5 COG0659 Sulfate permease and related transporters (MFS superfamily) K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 490.0
TLS2_k127_6812832_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 479.0
TLS2_k127_6812832_7 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 457.0
TLS2_k127_6812832_8 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004798 437.0
TLS2_k127_6812832_9 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 398.0
TLS2_k127_6828436_0 Hydantoinase/oxoprolinase N-terminal region K01469 - 3.5.2.9 0.0 1324.0
TLS2_k127_6828436_1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00124,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 523.0
TLS2_k127_6828436_10 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 352.0
TLS2_k127_6828436_11 COG0616 Periplasmic serine proteases (ClpP class) K04774 GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0016020,GO:0019538,GO:0043170,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 328.0
TLS2_k127_6828436_12 L,D-transpeptidase catalytic domain K16291 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 316.0
TLS2_k127_6828436_13 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 314.0
TLS2_k127_6828436_14 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001436 278.0
TLS2_k127_6828436_15 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000238 256.0
TLS2_k127_6828436_16 Oxygen tolerance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003116 265.0
TLS2_k127_6828436_17 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007747 251.0
TLS2_k127_6828436_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000002901 242.0
TLS2_k127_6828436_19 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000004444 243.0
TLS2_k127_6828436_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 505.0
TLS2_k127_6828436_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000002073 236.0
TLS2_k127_6828436_21 Phage tail sheath C-terminal domain K06907 - - 0.000000000000000000000000000000000000000000000000000000000001053 229.0
TLS2_k127_6828436_22 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000001375 200.0
TLS2_k127_6828436_23 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.00000000000000000000000000000000000000000000000796 186.0
TLS2_k127_6828436_24 Thioredoxin-like [2Fe-2S] ferredoxin K00127 - - 0.0000000000000000000000000000000000000000000003546 171.0
TLS2_k127_6828436_25 Domain of unknown function (DUF4381) - - - 0.00000000000000000000000000002276 123.0
TLS2_k127_6828436_26 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000002215 117.0
TLS2_k127_6828436_27 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.00000000000000000000454 100.0
TLS2_k127_6828436_3 Peptidase family S58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 491.0
TLS2_k127_6828436_4 Aspartate tyrosine aromatic aminotransferase K00813,K00832 - 2.6.1.1,2.6.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 437.0
TLS2_k127_6828436_5 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 443.0
TLS2_k127_6828436_6 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007798 422.0
TLS2_k127_6828436_7 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K11928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005357 438.0
TLS2_k127_6828436_8 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 394.0
TLS2_k127_6828436_9 Zn-dependent hydrolases including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 354.0
TLS2_k127_6830731_0 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 394.0
TLS2_k127_6830731_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005334 319.0
TLS2_k127_6830731_2 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000001723 164.0
TLS2_k127_6830731_3 NlpE N-terminal domain - - - 0.00000000000000000000000000001192 121.0
TLS2_k127_6867978_0 Cellobiose phosphorylase K00702,K13688,K18675 - 2.4.1.20,2.4.1.280 0.0 1995.0
TLS2_k127_6867978_1 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 613.0
TLS2_k127_6867978_10 Universal stress protein family - - - 0.00000000000308 77.0
TLS2_k127_6867978_2 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685 - 4.2.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 544.0
TLS2_k127_6867978_3 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 391.0
TLS2_k127_6867978_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000009944 263.0
TLS2_k127_6867978_5 Bacterial transcriptional repressor C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004676 260.0
TLS2_k127_6867978_6 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005616 277.0
TLS2_k127_6867978_7 Peptidase family M23 K21472 - - 0.000000000000000000000000000000000000000000000000000000000000000000002388 255.0
TLS2_k127_6867978_8 Protein of unknown function (DUF1761) - - - 0.000000000000000000000000000000000000000006952 158.0
TLS2_k127_6867978_9 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000005274 141.0
TLS2_k127_6941133_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 2.174e-321 1002.0
TLS2_k127_6941133_1 Outer membrane receptor - - - 1.526e-244 774.0
TLS2_k127_6941133_2 HNH endonuclease - - - 0.0008692 46.0
TLS2_k127_6950071_0 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 380.0
TLS2_k127_6950071_1 Domain of unknown function (DUF4383) - - - 0.00000000000000000000000000000000000000000000000000000000003151 208.0
TLS2_k127_6985516_0 Zinc carboxypeptidase - - - 6.565e-234 755.0
TLS2_k127_6985516_1 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 554.0
TLS2_k127_6985516_2 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001065 265.0
TLS2_k127_6985516_3 Belongs to the MtfA family K09933 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000001193 257.0
TLS2_k127_6985516_4 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000001621 209.0
TLS2_k127_6985516_5 alpha-glucosidase K01187 - 3.2.1.20 0.000000000000000000000000001047 115.0
TLS2_k127_6985516_6 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000002959 75.0
TLS2_k127_6985516_7 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 GO:0003674,GO:0003824,GO:0004620,GO:0004630,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008081,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016298,GO:0016740,GO:0016772,GO:0016780,GO:0016787,GO:0016788,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - 0.000000000005143 71.0
TLS2_k127_703398_0 glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 503.0
TLS2_k127_703398_1 Glutamine K07010 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 323.0
TLS2_k127_703398_2 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004511 283.0
TLS2_k127_703398_3 maleylacetoacetate isomerase K01801 - 5.2.1.4 0.00000000000000000000000000000000000000000000000000000000000001615 229.0
TLS2_k127_7055181_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 4.205e-274 867.0
TLS2_k127_7055181_1 hydrolase family 2, sugar binding K05970 - 3.1.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 601.0
TLS2_k127_7055181_2 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 394.0
TLS2_k127_7055181_3 - - - - 0.000000000000000000000000000001824 124.0
TLS2_k127_7055181_4 Endoglucanase K01179 - 3.2.1.4 0.000000000000000000000001988 103.0
TLS2_k127_7145257_0 aldehyde-lyase activity K01621 - 4.1.2.22,4.1.2.9 0.0 1270.0
TLS2_k127_7145257_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1129.0
TLS2_k127_7145257_10 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 325.0
TLS2_k127_7145257_11 Lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006782 316.0
TLS2_k127_7145257_12 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 312.0
TLS2_k127_7145257_13 Esterase PHB depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 291.0
TLS2_k127_7145257_14 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009266 269.0
TLS2_k127_7145257_15 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000005124 252.0
TLS2_k127_7145257_16 regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000000000000000000000001349 237.0
TLS2_k127_7145257_17 EcsC protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003822 243.0
TLS2_k127_7145257_18 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000002986 206.0
TLS2_k127_7145257_19 cytochrome - - - 0.000000000000000000000000000000000000000000000000003005 188.0
TLS2_k127_7145257_2 TonB dependent receptor - - - 0.0 1089.0
TLS2_k127_7145257_20 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000000002484 183.0
TLS2_k127_7145257_21 Thiol disulfide interchange protein K03673 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000001438 161.0
TLS2_k127_7145257_22 - - - - 0.00000000000000000000000000009876 132.0
TLS2_k127_7145257_23 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.000000000000003436 78.0
TLS2_k127_7145257_24 - - - - 0.0000013 58.0
TLS2_k127_7145257_3 receptor K02014 - - 2.814e-281 882.0
TLS2_k127_7145257_4 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 618.0
TLS2_k127_7145257_5 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 552.0
TLS2_k127_7145257_6 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 509.0
TLS2_k127_7145257_7 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 491.0
TLS2_k127_7145257_8 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 374.0
TLS2_k127_7145257_9 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 331.0
TLS2_k127_7174930_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1442.0
TLS2_k127_7174930_1 Peptidase family M49 - - - 5.557e-215 683.0
TLS2_k127_7174930_2 COG1533 DNA repair photolyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 362.0
TLS2_k127_7174930_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 317.0
TLS2_k127_7174930_4 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009985 313.0
TLS2_k127_7174930_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 292.0
TLS2_k127_7174930_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000001737 190.0
TLS2_k127_7174930_7 R COG0457 FOG TPR repeat - - - 0.0008167 52.0
TLS2_k127_7222977_0 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 4.702e-239 758.0
TLS2_k127_7222977_1 Sodium:sulfate symporter transmembrane region - - - 2.054e-210 685.0
TLS2_k127_7222977_2 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 549.0
TLS2_k127_7222977_3 Pyridine nucleotide-disulphide oxidoreductase K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 405.0
TLS2_k127_7222977_4 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 385.0
TLS2_k127_7222977_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 295.0
TLS2_k127_7222977_6 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000002486 105.0
TLS2_k127_7232962_0 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 503.0
TLS2_k127_7232962_1 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 477.0
TLS2_k127_7232962_2 Histidine-specific methyltransferase, SAM-dependent K18911 - 2.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 349.0
TLS2_k127_7232962_3 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000009056 180.0
TLS2_k127_7232962_4 Reprolysin (M12B) family zinc metalloprotease - - - 0.00000000000000000000000000000000000000000000002009 193.0
TLS2_k127_7232962_5 Phage integrase family - - - 0.00000000000000000000000000000000000000000000002277 172.0
TLS2_k127_7283547_0 Activates fatty acids by binding to coenzyme A K01897 - 6.2.1.3 2.473e-221 701.0
TLS2_k127_7283547_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 497.0
TLS2_k127_7283547_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 327.0
TLS2_k127_7283547_3 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000001653 222.0
TLS2_k127_7283547_4 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.000000000000000000000309 100.0
TLS2_k127_7305328_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 595.0
TLS2_k127_7305328_1 homocysteine K00297,K00547 GO:0003674,GO:0003824,GO:0005488,GO:0006575,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008270,GO:0008757,GO:0008898,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033477,GO:0033554,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901564 1.5.1.20,2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007201 311.0
TLS2_k127_7305328_2 Endonuclease Exonuclease Phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000001278 228.0
TLS2_k127_7319769_0 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 529.0
TLS2_k127_7319769_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000003003 233.0
TLS2_k127_7319769_2 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000003099 109.0
TLS2_k127_7319769_3 Pfam MotA TolQ ExbB proton channel family - - - 0.0001475 44.0
TLS2_k127_734699_0 Belongs to the flagella basal body rod proteins family K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 497.0
TLS2_k127_734699_1 Belongs to the bacterial flagellin family K02397 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 346.0
TLS2_k127_734699_2 Flagellar rod assembly protein muramidase FlgJ K02395 - - 0.000000000000000000000000000000000000000000000000000000000000000002083 240.0
TLS2_k127_7419821_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 1.249e-277 865.0
TLS2_k127_7419821_1 Peptidase dimerisation domain - - - 8.939e-248 774.0
TLS2_k127_7419821_10 (ABC) transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 365.0
TLS2_k127_7419821_11 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 366.0
TLS2_k127_7419821_12 Integral membrane sensor signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 320.0
TLS2_k127_7419821_13 Thrombospondin type 3 repeat K03286 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001495 274.0
TLS2_k127_7419821_14 Asp/Glu/Hydantoin racemase - - - 0.0000000000000000000000000000000000000000000000000000000000002162 219.0
TLS2_k127_7419821_15 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000007707 217.0
TLS2_k127_7419821_16 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000001347 202.0
TLS2_k127_7419821_17 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000003581 171.0
TLS2_k127_7419821_18 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20866 - 3.1.3.10 0.0000000000000000000000000000000004892 138.0
TLS2_k127_7419821_19 Domain of unknown function (DUF4340) - - - 0.0000000000000000000000000001763 131.0
TLS2_k127_7419821_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.682e-238 751.0
TLS2_k127_7419821_20 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000309 114.0
TLS2_k127_7419821_21 Belongs to the bacterial solute-binding protein 9 family K15727 - - 0.000000003229 70.0
TLS2_k127_7419821_3 Peptidase family M28 - - - 7.51e-201 647.0
TLS2_k127_7419821_4 ABC-type uncharacterized transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 542.0
TLS2_k127_7419821_5 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004592 452.0
TLS2_k127_7419821_6 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 436.0
TLS2_k127_7419821_7 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 409.0
TLS2_k127_7419821_8 geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 387.0
TLS2_k127_7419821_9 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 382.0
TLS2_k127_75086_0 TonB-dependent receptor - - - 7.842e-253 799.0
TLS2_k127_75086_1 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004064 276.0
TLS2_k127_75086_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000936 266.0
TLS2_k127_75086_3 E COG0620 Methionine synthase II (cobalamin-independent) - - - 0.000000000000000000000000000000002607 138.0
TLS2_k127_758241_0 Belongs to the heme-copper respiratory oxidase family K15408 - 1.9.3.1 0.0 1023.0
TLS2_k127_758241_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008978 628.0
TLS2_k127_758241_2 PFAM sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 533.0
TLS2_k127_758241_3 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005795 286.0
TLS2_k127_758241_4 phospholipid-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000593 237.0
TLS2_k127_758241_5 Predicted membrane protein (DUF2231) - - - 0.0000000000000000000000000000000000000000000000001817 181.0
TLS2_k127_758241_6 Uncharacterised protein family (UPF0093) - - - 0.000000000000000000000000000000000000000005902 162.0
TLS2_k127_758241_7 - - - - 0.000000000000000009693 87.0
TLS2_k127_759691_0 Vitamin K epoxide reductase family - - - 0.0 1026.0
TLS2_k127_759691_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 4.885e-279 878.0
TLS2_k127_759691_10 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 379.0
TLS2_k127_759691_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000486 299.0
TLS2_k127_759691_12 Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) K09880 - 3.1.3.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008953 274.0
TLS2_k127_759691_13 D-amino acid dehydrogenase K00285 - 1.4.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003648 283.0
TLS2_k127_759691_14 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 GO:0000096,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0010309,GO:0016491,GO:0016701,GO:0016702,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051213,GO:0055114,GO:0071704,GO:1901564,GO:1901605 1.13.11.53,1.13.11.54 0.00000000000000000000000000000000000000000000000000000000000000000000002998 246.0
TLS2_k127_759691_15 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.000000000000000000000000000000000000000000000000000000000629 203.0
TLS2_k127_759691_16 L-2,4-diaminobutyric acid acetyltransferase K06718 - 2.3.1.178 0.00000000000000000000000000000000000000000000000000003399 195.0
TLS2_k127_759691_17 Protein of unknown function (DUF3014) - - - 0.00000000000000000000000000000000000000000000000000006411 196.0
TLS2_k127_759691_18 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) K08964,K22130 - 4.1.1.104,4.2.1.109 0.000000000000000000000000000000000000000000000000003475 193.0
TLS2_k127_759691_19 universal stress protein K14055 - - 0.00000000000000000000000000000000000000000002086 174.0
TLS2_k127_759691_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.254e-274 876.0
TLS2_k127_759691_20 COG1846 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000005414 165.0
TLS2_k127_759691_21 Pyridoxamine 5'-phosphate oxidase like - - - 0.000000000000000000000000000000003332 138.0
TLS2_k127_759691_22 - - - - 0.00000000000000000000000000002443 127.0
TLS2_k127_759691_24 Universal stress protein family - - - 0.00000000000005183 83.0
TLS2_k127_759691_25 HupE / UreJ protein - - - 0.0000000000003048 77.0
TLS2_k127_759691_26 ChaB K06197 - - 0.0005579 50.0
TLS2_k127_759691_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 605.0
TLS2_k127_759691_4 ACT domain K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 580.0
TLS2_k127_759691_5 Dehydrogenase K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 562.0
TLS2_k127_759691_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00836 - 2.6.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 530.0
TLS2_k127_759691_7 Multidrug DMT transporter permease K10674 - 1.14.11.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 419.0
TLS2_k127_759691_8 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 421.0
TLS2_k127_759691_9 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 390.0
TLS2_k127_805820_0 TonB dependent receptor K02014 - - 4.327e-262 835.0
TLS2_k127_805820_1 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 2.325e-221 708.0
TLS2_k127_805820_10 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 489.0
TLS2_k127_805820_11 protein conserved in bacteria K16514 GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 5.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 491.0
TLS2_k127_805820_12 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 489.0
TLS2_k127_805820_13 PFAM amidohydrolase 2 K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 479.0
TLS2_k127_805820_14 Major Facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 479.0
TLS2_k127_805820_15 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 421.0
TLS2_k127_805820_16 transcriptional regulator K16516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 366.0
TLS2_k127_805820_17 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 347.0
TLS2_k127_805820_18 COG0684 Demethylmenaquinone methyltransferase K10218 - 4.1.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 323.0
TLS2_k127_805820_19 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 321.0
TLS2_k127_805820_2 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 3.322e-213 674.0
TLS2_k127_805820_20 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002309 282.0
TLS2_k127_805820_21 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000713 275.0
TLS2_k127_805820_22 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008061 267.0
TLS2_k127_805820_23 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000000808 205.0
TLS2_k127_805820_24 COG3209 Rhs family protein - - - 0.0000000000000000000000000000000000000000000000000003293 193.0
TLS2_k127_805820_25 PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - 0.0000000000000000000000000000000000002472 144.0
TLS2_k127_805820_26 - - - - 0.0000000000000000000007986 102.0
TLS2_k127_805820_27 Glycine zipper 2TM domain K06077 - - 0.000000000000000000002749 99.0
TLS2_k127_805820_28 PFAM regulatory protein MarR - - - 0.0000000000000000006716 94.0
TLS2_k127_805820_29 Sigma-70, region 4 K03088 GO:0000988,GO:0000990,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000001907 84.0
TLS2_k127_805820_3 AMP-binding enzyme K12508 - 6.2.1.34 3.493e-205 655.0
TLS2_k127_805820_30 Alpha beta hydrolase - - - 0.0000001602 63.0
TLS2_k127_805820_31 Protein of unknown function (DUF3018) - - - 0.00001663 51.0
TLS2_k127_805820_32 Belongs to the glycosyl hydrolase 3 family K05349 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009057,GO:0009251,GO:0015926,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044042,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901575 3.2.1.21 0.0009906 45.0
TLS2_k127_805820_4 metal-dependent hydrolase of the TIM-barrel fold K03392,K10220 - 4.1.1.45,4.2.1.83 1.612e-200 627.0
TLS2_k127_805820_5 Catalyzes the formation of protocatechuate from 4-hydroxybenzoate K00481 - 1.14.13.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007632 599.0
TLS2_k127_805820_6 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008045 573.0
TLS2_k127_805820_7 dehydrogenases and related proteins K10219 - 1.1.1.312 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 536.0
TLS2_k127_805820_8 Thiol disulfide Interchange Protein K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 552.0
TLS2_k127_805820_9 metal-dependent hydrolase of the TIM-barrel fold K10221 - 3.1.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 506.0
TLS2_k127_81263_0 Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs K15257 GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016740,GO:0016741,GO:0016765,GO:0022607,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 318.0
TLS2_k127_81263_1 Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) K15256 GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000006188 241.0
TLS2_k127_81263_2 Belongs to the GbsR family - - - 0.0000000000000000000000000000000000000000000000000000000000001846 216.0
TLS2_k127_81263_3 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.0000000000000000000000000000000000000000000000001666 181.0
TLS2_k127_81263_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000006671 86.0
TLS2_k127_81263_5 - - - - 0.00000003488 55.0
TLS2_k127_81263_6 ChrR Cupin-like domain - - - 0.0004584 47.0
TLS2_k127_821773_0 His Kinase A (phosphoacceptor) domain - - - 5.399e-207 696.0
TLS2_k127_821773_1 DNA polymerase type-B family K02336 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006725 613.0
TLS2_k127_821773_10 Copper homeostasis K06079 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0010810,GO:0016020,GO:0019867,GO:0030155,GO:0030312,GO:0030313,GO:0031975,GO:0042802,GO:0044462,GO:0044464,GO:0050789,GO:0065007,GO:0071944 - 0.000321 51.0
TLS2_k127_821773_2 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 295.0
TLS2_k127_821773_3 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005134 257.0
TLS2_k127_821773_4 Lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000008045 227.0
TLS2_k127_821773_5 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000000000000000000000001438 198.0
TLS2_k127_821773_6 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000000000000000000000000000000000001848 183.0
TLS2_k127_821773_7 bis(5'-adenosyl)-triphosphatase activity K02503 - - 0.00000000000000000000000000000000000009188 150.0
TLS2_k127_821773_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000001854 145.0
TLS2_k127_821773_9 Endoribonuclease L-PSP - - - 0.000000000000000006603 95.0
TLS2_k127_876135_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 555.0
TLS2_k127_876135_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 491.0
TLS2_k127_876135_10 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000009226 176.0
TLS2_k127_876135_11 PFAM electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000004307 143.0
TLS2_k127_876135_12 Copper chaperone PCu(A)C K09796 - - 0.00000000003972 74.0
TLS2_k127_876135_2 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 325.0
TLS2_k127_876135_3 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 311.0
TLS2_k127_876135_4 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 301.0
TLS2_k127_876135_5 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 291.0
TLS2_k127_876135_6 FimV C-terminal K08086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008374 304.0
TLS2_k127_876135_7 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000004976 254.0
TLS2_k127_876135_8 GAF domain-containing protein K08968 - 1.8.4.14 0.000000000000000000000000000000000000000000000000000004117 195.0
TLS2_k127_876135_9 PFAM EAL domain K21025 - - 0.0000000000000000000000000000000000000000000000000004275 205.0
TLS2_k127_9128_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009597 492.0
TLS2_k127_9128_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 411.0
TLS2_k127_9128_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009177 286.0
TLS2_k127_9128_3 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003198 278.0
TLS2_k127_9128_4 Ribosomal RNA adenine dimethylase - - - 0.0000000000000000000000000000000000000000000000000004369 190.0
TLS2_k127_9128_5 - - - - 0.000000000000000000000000000000000000000000000001633 190.0
TLS2_k127_9128_7 MASE1 - - - 0.000000000000000000000000000005679 136.0
TLS2_k127_9128_8 COG3279 Response regulator of the LytR AlgR family K02477 - - 0.00000000000000000000000003599 119.0
TLS2_k127_9128_9 PAS fold - - - 0.000000001999 70.0
TLS2_k127_942421_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 7.563e-294 907.0
TLS2_k127_942795_0 Immune inhibitor A peptidase M6 K09607 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - 2.607e-199 634.0
TLS2_k127_942795_1 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 608.0
TLS2_k127_942795_10 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 291.0
TLS2_k127_942795_11 HipA N-terminal domain K07154 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 290.0
TLS2_k127_942795_12 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 285.0
TLS2_k127_942795_13 Metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006909 245.0
TLS2_k127_942795_14 Plasmid pRiA4b ORF-3-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000004459 228.0
TLS2_k127_942795_15 COG3209 Rhs family protein - - - 0.00000000000000000000000000000000000000000000000000000000001076 223.0
TLS2_k127_942795_16 - - - - 0.0000000000000000000000000000000000000000000000000000002259 208.0
TLS2_k127_942795_17 B-1 B cell differentiation - - - 0.0000000000000000000000000000000005097 145.0
TLS2_k127_942795_19 Transglycosylase associated protein - - - 0.000000000000000000000000001611 113.0
TLS2_k127_942795_2 Astacin (Peptidase family M12A) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 478.0
TLS2_k127_942795_20 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000004501 111.0
TLS2_k127_942795_21 Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000008835 106.0
TLS2_k127_942795_22 - - - - 0.00000000000000000001176 94.0
TLS2_k127_942795_23 Helix-turn-helix domain - - - 0.0000000000000000004493 88.0
TLS2_k127_942795_25 Conserved Protein - - - 0.00000000000001206 83.0
TLS2_k127_942795_26 Protein of unknown function DUF86 - - - 0.0000000000001323 76.0
TLS2_k127_942795_27 Peptidoglycan-binding domain 1 protein - - - 0.0000000000004866 72.0
TLS2_k127_942795_28 Astacin (Peptidase family M12A) - - - 0.000000000009593 68.0
TLS2_k127_942795_29 phosphoesterases, related to the Icc protein - - - 0.0000000003749 65.0
TLS2_k127_942795_3 Phage tail sheath protein subtilisin-like domain K06907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 461.0
TLS2_k127_942795_30 Protein of unknown function (DUF502) - - - 0.0000000005974 62.0
TLS2_k127_942795_31 - - - - 0.000000004202 59.0
TLS2_k127_942795_32 Tetratricopeptide repeats - - - 0.00000001358 59.0
TLS2_k127_942795_34 Calcineurin-like phosphoesterase superfamily domain - - - 0.00001744 53.0
TLS2_k127_942795_35 Peptidoglycan-binding domain 1 protein - - - 0.00002283 49.0
TLS2_k127_942795_36 Protein of unknown function DUF86 - - - 0.00003538 47.0
TLS2_k127_942795_4 transcription regulator containing HTH domain K18831 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 422.0
TLS2_k127_942795_5 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 417.0
TLS2_k127_942795_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 396.0
TLS2_k127_942795_7 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 362.0
TLS2_k127_942795_8 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 350.0
TLS2_k127_942795_9 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 357.0
TLS2_k127_946245_0 TonB-dependent Receptor Plug Domain - - - 0.0 1247.0
TLS2_k127_946245_1 Tryptophan halogenase - - - 2.173e-212 670.0
TLS2_k127_946245_2 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 454.0
TLS2_k127_955485_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1283.0
TLS2_k127_955485_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 2.476e-304 948.0
TLS2_k127_955485_10 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000003972 248.0
TLS2_k127_955485_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000001785 246.0
TLS2_k127_955485_12 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772,K19696 - 2.4.2.28,2.4.2.44 0.0000000000000000000000000000000000000000000000000000000000000000000002511 246.0
TLS2_k127_955485_13 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000004623 223.0
TLS2_k127_955485_14 Involved in DNA repair and RecF pathway recombination K03584 GO:0008150,GO:0009314,GO:0009628,GO:0050896 - 0.000000000000000000000000000000000000000000000000209 185.0
TLS2_k127_955485_15 PFAM MucB RseB K03598 - - 0.000000000000000000000000000000000000000000009337 175.0
TLS2_k127_955485_16 Belongs to the GcvT family K06980 - - 0.000000000000000000000000000000009601 141.0
TLS2_k127_955485_17 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.0000000000000000000000000000005555 129.0
TLS2_k127_955485_18 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000142 121.0
TLS2_k127_955485_19 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000001301 113.0
TLS2_k127_955485_2 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.503e-292 913.0
TLS2_k127_955485_20 Diguanylate cyclase - - - 0.000000000000001758 87.0
TLS2_k127_955485_21 An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH K00240,K09159 GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 1.3.5.1,1.3.5.4 0.0000000000002782 72.0
TLS2_k127_955485_22 Domain of unknown function (DUF4845) - - - 0.0000000000003006 76.0
TLS2_k127_955485_23 PFAM glutaredoxin 2 - - - 0.000000000001458 71.0
TLS2_k127_955485_24 Peptidoglycan-binding protein, CsiV - - - 0.00000000002605 74.0
TLS2_k127_955485_25 UPF0369 protein C6orf57 homolog - GO:0008150,GO:0022603,GO:0050789,GO:0050793,GO:0051239,GO:0065007,GO:0090175,GO:1905330,GO:2000026,GO:2000027 - 0.0000006053 55.0
TLS2_k127_955485_26 An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E K03597 GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.00006177 53.0
TLS2_k127_955485_27 Positive regulator of sigma(E), RseC/MucC K03803 GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0001219 51.0
TLS2_k127_955485_3 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 454.0
TLS2_k127_955485_4 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 417.0
TLS2_k127_955485_5 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 365.0
TLS2_k127_955485_6 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 367.0
TLS2_k127_955485_7 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 315.0
TLS2_k127_955485_8 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009236 304.0
TLS2_k127_955485_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003815 255.0
TLS2_k127_96272_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 2134.0
TLS2_k127_96272_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 342.0
TLS2_k127_96272_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005699 245.0
TLS2_k127_96272_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000008119 201.0
TLS2_k127_96272_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000004011 160.0
TLS2_k127_97785_0 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 298.0
TLS2_k127_97785_1 - - - - 0.00000000000000000000000003261 110.0
TLS2_k127_99617_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 538.0
TLS2_k127_99617_1 signal transduction histidine kinase K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 322.0
TLS2_k127_99617_2 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000006592 190.0
TLS2_k127_99617_3 Domain of unknown function (DUF4124) - - - 0.000000000000000003253 92.0
TLS2_k127_999096_0 DNA ligase (ATP) activity K01971 - 6.5.1.1 8.183e-265 840.0
TLS2_k127_999096_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 415.0
TLS2_k127_999096_10 endonuclease activity - - - 0.00002496 49.0
TLS2_k127_999096_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 293.0
TLS2_k127_999096_3 TPR repeat - - - 0.000000000000000000000000000000000000000000001359 175.0
TLS2_k127_999096_4 methyltransferase activity - - - 0.00000000000000000000000000000000000000000002439 169.0
TLS2_k127_999096_5 peptidase - - - 0.000000000000000000000000000001553 134.0
TLS2_k127_999096_6 CcdB protein K19163 - - 0.0000000000000005515 83.0
TLS2_k127_999096_7 Peptidoglycan-binding domain 1 protein - - - 0.00000000004353 69.0
TLS2_k127_999096_8 Domain of unknown function (DUF4404) - - - 0.000000004842 61.0