logo

Overview

ID MAG04046
Name TLS3_bin.23
Sample SMP0105
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Burkholderiaceae
Genus
Species
Assembly information
Completeness (%) 75.29
Contamination (%) 2.57
GC content (%) 65.0
N50 (bp) 5,369
Genome size (bp) 2,283,619

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2445

Gene name Description KEGG GOs EC E-value Score Sequence
TLS3_k127_1007424_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 3.508e-209 665.0
TLS3_k127_1007424_1 ABC-type Fe3 transport system, periplasmic component - - - 2.048e-194 617.0
TLS3_k127_1007424_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 607.0
TLS3_k127_1007424_3 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 489.0
TLS3_k127_1007424_4 phosphoserine phosphatase K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 288.0
TLS3_k127_1007424_5 Polyhydroxyalkanoate synthesis repressor PhaR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004452 276.0
TLS3_k127_1007424_6 Glutathione S-transferase, N-terminal domain K11208 - - 0.000000000000000000000000000000000000001275 155.0
TLS3_k127_1007424_7 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000003033 142.0
TLS3_k127_1009069_0 KR domain K00034 - 1.1.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 293.0
TLS3_k127_1009069_1 NAD dependent epimerase/dehydratase family K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000002294 260.0
TLS3_k127_1009069_2 Aminotransferase class-III K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000000001124 240.0
TLS3_k127_1014506_0 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 308.0
TLS3_k127_1014506_1 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004416 242.0
TLS3_k127_1014506_2 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000001674 227.0
TLS3_k127_1014506_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000002722 219.0
TLS3_k127_1014506_4 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.0000000000000000000000000000000000000000000000000002532 189.0
TLS3_k127_1014506_5 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000000000000001312 164.0
TLS3_k127_1014506_6 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000000000001408 146.0
TLS3_k127_1014506_7 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000008305 128.0
TLS3_k127_1014506_8 Ribosomal L29 protein K02904 - - 0.000000000000005526 79.0
TLS3_k127_1035815_0 Sigma-54 interaction domain K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 522.0
TLS3_k127_1035815_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 384.0
TLS3_k127_1035815_2 His Kinase A (phosphoacceptor) domain K02668,K10125 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 355.0
TLS3_k127_1035815_3 Cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004747 246.0
TLS3_k127_1036349_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 382.0
TLS3_k127_1036349_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 340.0
TLS3_k127_1036349_2 - - - - 0.00000000000000000004786 96.0
TLS3_k127_1046960_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 347.0
TLS3_k127_1046960_1 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 329.0
TLS3_k127_1046960_2 glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000001884 123.0
TLS3_k127_1046960_3 Protein of unknown function (DUF2905) - - - 0.000000000000001569 78.0
TLS3_k127_1046960_4 Major facilitator superfamily K08225 - - 0.00001734 49.0
TLS3_k127_1052523_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.166e-206 648.0
TLS3_k127_1052523_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 409.0
TLS3_k127_1052523_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 403.0
TLS3_k127_1052523_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000003905 247.0
TLS3_k127_1052523_4 Protein of unknown function (DUF2868) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003817 244.0
TLS3_k127_1052523_5 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000006779 208.0
TLS3_k127_1052523_6 - - - - 0.00000000000000008031 88.0
TLS3_k127_1052523_7 Belongs to the UPF0337 (CsbD) family - - - 0.000000000594 62.0
TLS3_k127_1053417_0 Dehydrogenase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 520.0
TLS3_k127_1053417_1 Proteasome subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008014 276.0
TLS3_k127_1053417_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007289 268.0
TLS3_k127_1054292_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 1.489e-317 989.0
TLS3_k127_1054292_1 Molecular chaperone. Has ATPase activity K04079 - - 1.455e-290 903.0
TLS3_k127_1054292_10 Part of a membrane complex involved in electron transport K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000036 231.0
TLS3_k127_1054292_11 glycosylase K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000000000000006346 203.0
TLS3_k127_1054292_12 Domain of unknown function (DUF1841) - - - 0.000000000000000000000000000000000000000000000000000001571 195.0
TLS3_k127_1054292_13 Protein of unknown function (DUF1631) - - - 0.0000000000000000000000000000000000000000000000000519 203.0
TLS3_k127_1054292_14 Copper resistance protein D - - - 0.00000000000000000000000000000001496 134.0
TLS3_k127_1054292_15 Protein of unknown function (DUF1631) - - - 0.00000000000000000000000000006273 135.0
TLS3_k127_1054292_16 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000004171 114.0
TLS3_k127_1054292_17 PFAM Cytochrome c, class I - - - 0.00000000000000000000000002484 111.0
TLS3_k127_1054292_18 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000002993 104.0
TLS3_k127_1054292_2 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 2.758e-229 726.0
TLS3_k127_1054292_3 VWA domain containing CoxE-like protein K09989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 568.0
TLS3_k127_1054292_4 ATPase (AAA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 492.0
TLS3_k127_1054292_5 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 319.0
TLS3_k127_1054292_6 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 330.0
TLS3_k127_1054292_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 286.0
TLS3_k127_1054292_8 Spermidine synthase K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000004369 276.0
TLS3_k127_1054292_9 TIGRFAM phenazine biosynthesis protein PhzF family K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000009486 253.0
TLS3_k127_1056766_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 1.103e-302 941.0
TLS3_k127_1056766_1 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 524.0
TLS3_k127_1056766_2 Protein of unknown function (DUF3025) - - - 0.0000000000000000000000000000000000000000000000000000000000002574 220.0
TLS3_k127_1056880_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 5.346e-294 921.0
TLS3_k127_1056880_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 8.182e-223 702.0
TLS3_k127_1056880_10 Smr protein MutS2 - - - 0.00000000000000000000000000000000000000000000000000000000000000001825 240.0
TLS3_k127_1056880_11 Belongs to the P(II) protein family K04751,K04752 - - 0.00000000000000000000000000000000000000000000000000000002834 198.0
TLS3_k127_1056880_12 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000007541 194.0
TLS3_k127_1056880_13 Histidine kinase - - - 0.0000000000000000000832 103.0
TLS3_k127_1056880_14 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000009638 51.0
TLS3_k127_1056880_2 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 8.112e-216 686.0
TLS3_k127_1056880_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 531.0
TLS3_k127_1056880_4 Peptidogalycan biosysnthesis/recognition K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007891 463.0
TLS3_k127_1056880_5 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 286.0
TLS3_k127_1056880_6 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006942 273.0
TLS3_k127_1056880_7 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006251 271.0
TLS3_k127_1056880_8 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001062 248.0
TLS3_k127_1056880_9 EamA-like transporter family K15268 - - 0.000000000000000000000000000000000000000000000000000000000000000000007427 244.0
TLS3_k127_106260_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1403.0
TLS3_k127_106260_1 PFAM ATP-binding region, ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 336.0
TLS3_k127_106260_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000006212 219.0
TLS3_k127_1069917_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 558.0
TLS3_k127_1069917_1 NADPH quinone oxidoreductase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 451.0
TLS3_k127_1069917_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000003365 198.0
TLS3_k127_1074233_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 359.0
TLS3_k127_1074233_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000001253 197.0
TLS3_k127_1074233_2 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.0000000000000000000000000000000000000000000002862 181.0
TLS3_k127_1102972_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 4.461e-198 630.0
TLS3_k127_1102972_1 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 337.0
TLS3_k127_1102972_2 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000008732 110.0
TLS3_k127_1107614_0 Sodium:sulfate symporter transmembrane region K11106,K14445 - - 1.76e-205 648.0
TLS3_k127_1107614_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K17837 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 321.0
TLS3_k127_1107614_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000005937 176.0
TLS3_k127_1107614_3 - - - - 0.0000000000000000000000007529 108.0
TLS3_k127_1108292_0 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 551.0
TLS3_k127_1108292_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 476.0
TLS3_k127_1108292_2 Sporulation related domain K03749 - - 0.000000000000000000000002086 113.0
TLS3_k127_1108292_3 membrane protein, required for colicin V production K03558 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - 0.0000000000000000002353 100.0
TLS3_k127_1108292_4 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000007372 71.0
TLS3_k127_1111923_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 5.195e-218 687.0
TLS3_k127_1111923_1 PFAM NUDIX hydrolase K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000006545 207.0
TLS3_k127_1111923_2 peptidase M48, Ste24p - - - 0.0000000000000000000000000000000000000000000241 172.0
TLS3_k127_1111923_3 - - - - 0.0000000000000000000000000000000000000007505 157.0
TLS3_k127_1111923_4 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000000000000000004349 124.0
TLS3_k127_1111923_5 Belongs to the UPF0145 family - - - 0.00002085 49.0
TLS3_k127_1138020_0 Cysteine-rich domain - - - 1.879e-204 648.0
TLS3_k127_1138020_1 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 496.0
TLS3_k127_1138020_10 Protein of unknown function (DUF3501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001821 250.0
TLS3_k127_1138020_11 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000006526 239.0
TLS3_k127_1138020_12 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000000121 206.0
TLS3_k127_1138020_13 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000000000006157 138.0
TLS3_k127_1138020_14 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000006389 128.0
TLS3_k127_1138020_15 Putative prokaryotic signal transducing protein - - - 0.0000000000000000000000000004871 116.0
TLS3_k127_1138020_16 TM2 domain - - - 0.0000000000000000000006281 102.0
TLS3_k127_1138020_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 451.0
TLS3_k127_1138020_3 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 321.0
TLS3_k127_1138020_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001008 285.0
TLS3_k127_1138020_5 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003267 265.0
TLS3_k127_1138020_6 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002913 268.0
TLS3_k127_1138020_7 PFAM Acyl-CoA dehydrogenase N terminal, Acyl-CoA dehydrogenase, C-terminal domain, Acyl-CoA dehydrogenase, middle domain, Acyl-CoA dehydrogenase, N-terminal domain K20035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002497 264.0
TLS3_k127_1138020_8 PFAM NUDIX hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004832 256.0
TLS3_k127_1138020_9 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000001486 256.0
TLS3_k127_1142983_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 338.0
TLS3_k127_1142983_1 Ribonuclease, BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005485 320.0
TLS3_k127_1142983_2 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003534 275.0
TLS3_k127_1142983_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001583 262.0
TLS3_k127_1142983_4 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.0000000000000000004713 88.0
TLS3_k127_1146172_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 479.0
TLS3_k127_1146172_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001337 241.0
TLS3_k127_1146172_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000002905 184.0
TLS3_k127_1146172_3 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000000000308 104.0
TLS3_k127_115421_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 460.0
TLS3_k127_115421_1 Proton-conducting membrane transporter - - - 0.000000000000000000000000000000000000000007817 158.0
TLS3_k127_115421_2 PFAM CopG domain protein DNA-binding domain protein - - - 0.00000000000000000009195 90.0
TLS3_k127_1158735_0 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 369.0
TLS3_k127_1158735_1 LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 347.0
TLS3_k127_1158735_2 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006055 259.0
TLS3_k127_1158735_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000001094 252.0
TLS3_k127_1158735_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000006727 207.0
TLS3_k127_1158735_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000005852 211.0
TLS3_k127_1158735_6 Belongs to the Smg family K03747 - - 0.00000000000000000000000000000000000000001112 161.0
TLS3_k127_1168821_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 1.43e-293 912.0
TLS3_k127_1168821_1 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 3.663e-226 713.0
TLS3_k127_1168821_2 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 474.0
TLS3_k127_1168821_3 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000000000001686 143.0
TLS3_k127_1168821_4 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 0.0000000000000000000000000000000002928 132.0
TLS3_k127_1175957_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1170.0
TLS3_k127_1175957_1 Selenocysteine synthase N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 505.0
TLS3_k127_1175957_2 Formate dehydrogenase N, transmembrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 473.0
TLS3_k127_1175957_3 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000158 288.0
TLS3_k127_1175957_4 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006014 254.0
TLS3_k127_1175957_5 Necessary for formate dehydrogenase activity K02380 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009353 251.0
TLS3_k127_1197212_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005915 512.0
TLS3_k127_1197212_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000000000001528 187.0
TLS3_k127_1197212_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000227 106.0
TLS3_k127_1208814_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 545.0
TLS3_k127_1221456_0 rod shape-determining protein MreD K03571 - - 0.000000000000000000000000000000000000000000000000000000000000000005589 235.0
TLS3_k127_1221456_1 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000004771 224.0
TLS3_k127_1221456_2 - - - - 0.0000000000009751 69.0
TLS3_k127_1245475_0 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 537.0
TLS3_k127_1245475_1 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 329.0
TLS3_k127_1245475_2 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 304.0
TLS3_k127_1245475_3 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000004122 243.0
TLS3_k127_1245475_4 Shikimate kinase K00851 - 2.7.1.12 0.000000000000000000000000000000000000000000000000000001254 202.0
TLS3_k127_125361_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.611e-270 837.0
TLS3_k127_125361_1 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 415.0
TLS3_k127_125361_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 385.0
TLS3_k127_125361_3 membrane K08972 - - 0.00000000000000000000000000000000003865 138.0
TLS3_k127_1276815_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006133 429.0
TLS3_k127_1276815_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006774 364.0
TLS3_k127_128494_0 Protein of unknown function (DUF3570) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007863 333.0
TLS3_k127_128494_1 Redoxin - - - 0.00000000000000000000000000000000000000000000000006271 181.0
TLS3_k127_128494_2 Domain of unknown function (DUF4266) - - - 0.00000000000000003765 85.0
TLS3_k127_128494_3 ApbE family K03734 - 2.7.1.180 0.0000000000000002486 81.0
TLS3_k127_128525_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.915e-251 779.0
TLS3_k127_128525_1 SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 K00240 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 426.0
TLS3_k127_128525_2 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000000001205 97.0
TLS3_k127_1292237_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 475.0
TLS3_k127_1292237_1 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.000000000000000000000000000000000000000000000000000000000183 221.0
TLS3_k127_1292237_2 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000739 103.0
TLS3_k127_1292237_3 Belongs to the transcriptional regulatory Fis family K03557 - - 0.0000000000000000000001826 103.0
TLS3_k127_1335214_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 1.944e-268 836.0
TLS3_k127_1335214_1 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 310.0
TLS3_k127_1335214_2 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000009721 108.0
TLS3_k127_1335214_3 Protein of unknown function (DUF721) - - - 0.000007568 55.0
TLS3_k127_1346703_0 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 351.0
TLS3_k127_1346703_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001211 279.0
TLS3_k127_1346703_2 Major facilitator superfamily K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000003236 238.0
TLS3_k127_1346703_3 - - - - 0.000000000000000009943 92.0
TLS3_k127_1383576_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 1.022e-233 732.0
TLS3_k127_1383576_1 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 459.0
TLS3_k127_1383576_2 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 420.0
TLS3_k127_1383576_3 PFAM Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 323.0
TLS3_k127_1383576_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000003269 183.0
TLS3_k127_1383576_5 protein conserved in bacteria K09790 - - 0.0000000000000000000000000000000000001957 145.0
TLS3_k127_1383576_6 Domain of unknown function (DUF4112) - - - 0.00000000000000000000000000001317 122.0
TLS3_k127_1383576_7 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000001761 53.0
TLS3_k127_1400697_0 glutamate--cysteine ligase K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 616.0
TLS3_k127_1400697_1 ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 532.0
TLS3_k127_1400697_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 471.0
TLS3_k127_1400697_3 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 392.0
TLS3_k127_1400697_4 pts system fructose subfamily IIa component K02821 - 2.7.1.194 0.00000000000000000000000000000000000001026 149.0
TLS3_k127_1400697_5 phosphocarrier, HPr family K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000006838 117.0
TLS3_k127_1468254_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.282e-225 717.0
TLS3_k127_1501755_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 5.281e-279 868.0
TLS3_k127_1501755_1 Belongs to the phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 356.0
TLS3_k127_1501755_2 Protein of unknown function (DUF3224) - - - 0.00000000000000000000000000000000000000000000000003987 182.0
TLS3_k127_15051_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 553.0
TLS3_k127_15051_1 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006229 266.0
TLS3_k127_15051_2 Bacterial protein of unknown function (DUF924) - - - 0.00000000000000000000000000000000000000000000000000001473 196.0
TLS3_k127_151558_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 293.0
TLS3_k127_151558_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003217 277.0
TLS3_k127_151558_2 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.00000000000000000000000000000000006037 136.0
TLS3_k127_1525793_0 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 596.0
TLS3_k127_1525793_1 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000001864 121.0
TLS3_k127_1525793_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00001591 47.0
TLS3_k127_1529789_0 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 2.56e-247 781.0
TLS3_k127_1529789_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 404.0
TLS3_k127_15446_0 Mo-co oxidoreductase dimerisation domain K05301 - 1.8.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 565.0
TLS3_k127_15446_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000001901 113.0
TLS3_k127_1550_0 PFAM PhoH family protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 428.0
TLS3_k127_1550_1 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000007559 134.0
TLS3_k127_1550_2 Domain of unknown function (DUF5117) - - - 0.00000000000000000000000000000003894 132.0
TLS3_k127_1584308_0 Beta propeller domain - - - 1.053e-225 711.0
TLS3_k127_1584308_1 Type I phosphodiesterase / nucleotide pyrophosphatase K19670 - 3.11.1.2 0.00003744 48.0
TLS3_k127_1593100_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 393.0
TLS3_k127_1593100_1 PFAM conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 352.0
TLS3_k127_1593100_2 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002849 230.0
TLS3_k127_1593100_3 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661,K07536 - 4.1.3.36 0.000000000000000000003302 93.0
TLS3_k127_1613463_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 453.0
TLS3_k127_1613463_1 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 391.0
TLS3_k127_1613463_2 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002988 261.0
TLS3_k127_1613463_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000002135 250.0
TLS3_k127_1613463_4 Yqey-like protein - - - 0.00000000000000000000000000000000000000000000000006242 182.0
TLS3_k127_1613463_5 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000001678 145.0
TLS3_k127_1613463_6 Chalcone isomerase-like - - - 0.000000000000000000000000000000000003239 140.0
TLS3_k127_1613463_7 Ribosomal protein S21 K02970 - - 0.00000000000000000000000000000006093 126.0
TLS3_k127_1644927_0 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000001415 235.0
TLS3_k127_1644927_1 DNA polymerase III, delta' K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000004485 220.0
TLS3_k127_1644927_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000001124 109.0
TLS3_k127_1707713_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 488.0
TLS3_k127_1707713_1 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000001904 119.0
TLS3_k127_1707713_2 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000000005767 78.0
TLS3_k127_1707713_3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme - - - 0.000000008034 66.0
TLS3_k127_1715471_0 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000000000000004182 235.0
TLS3_k127_1715471_1 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000009362 227.0
TLS3_k127_1715471_2 Bacterial protein of unknown function (DUF883) - - - 0.000000000000000000001912 97.0
TLS3_k127_1725926_0 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 360.0
TLS3_k127_1725926_1 histone deacetylase - - - 0.000000000000000000000000000005662 119.0
TLS3_k127_1729644_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006278 548.0
TLS3_k127_1729644_1 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006694 368.0
TLS3_k127_1729644_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005995 314.0
TLS3_k127_1729644_3 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000000000000000000000000000000004062 213.0
TLS3_k127_1729644_4 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000000000000000322 134.0
TLS3_k127_1729644_5 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000009167 59.0
TLS3_k127_1729644_6 membrane K08985 - - 0.0000005689 59.0
TLS3_k127_1731562_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.141e-247 784.0
TLS3_k127_1731562_1 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 467.0
TLS3_k127_1731562_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 424.0
TLS3_k127_1731562_3 cell division K09812 - - 0.0000000000000000000000000000000000000000000000000004186 192.0
TLS3_k127_1731562_4 Methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000000006066 198.0
TLS3_k127_1731562_5 phosphohistidine phosphatase K08296 - - 0.000000000000000000000000000000000000000000000002407 177.0
TLS3_k127_1731562_6 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000003884 57.0
TLS3_k127_1738398_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 3.419e-237 750.0
TLS3_k127_1738398_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 483.0
TLS3_k127_1738398_2 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 477.0
TLS3_k127_1738398_3 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032,K13892,K13896 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000002892 139.0
TLS3_k127_1738398_4 ABC-type dipeptide transport system, periplasmic component - - - 0.000000000000000000000000000003713 122.0
TLS3_k127_1753454_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 6.361e-197 626.0
TLS3_k127_1753454_1 Sodium Bile acid symporter family K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 552.0
TLS3_k127_1753454_2 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 525.0
TLS3_k127_1753454_3 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 491.0
TLS3_k127_1753454_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 317.0
TLS3_k127_1753454_5 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000000003552 233.0
TLS3_k127_1753454_6 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000139 176.0
TLS3_k127_1753454_7 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000004648 131.0
TLS3_k127_1758740_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.191e-209 663.0
TLS3_k127_1758740_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007932 471.0
TLS3_k127_1758740_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000236 52.0
TLS3_k127_1766707_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.252e-252 785.0
TLS3_k127_1766707_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 446.0
TLS3_k127_1766707_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 362.0
TLS3_k127_1766707_3 Peptidase M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 311.0
TLS3_k127_1766707_4 Dioxygenase K00449 - 1.13.11.3 0.000000000000000000000000000000000000007807 153.0
TLS3_k127_1766707_5 Nucleoside H+ symporter K05820 - - 0.00000000000000000007857 92.0
TLS3_k127_1766707_6 Entericidin EcnA/B family - - - 0.000000618 51.0
TLS3_k127_1767828_0 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 294.0
TLS3_k127_1767828_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004486 279.0
TLS3_k127_1767828_2 response to antibiotic - - - 0.00000000000000000000000000000000000000000000000000000000000000000001402 250.0
TLS3_k127_1767828_3 Protein of unknown function (DUF3299) K09950 - - 0.0000000000000000000000000000004435 124.0
TLS3_k127_1789477_0 Outer membrane usher protein K07347 - - 0.00000000000000000000000006911 121.0
TLS3_k127_1789477_1 Spore Coat Protein U domain - - - 0.000000000004748 73.0
TLS3_k127_1803629_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1038.0
TLS3_k127_1803629_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.93e-251 795.0
TLS3_k127_1803629_10 Circularly permuted ATP-grasp type 2 - - - 0.00002678 49.0
TLS3_k127_1803629_2 KR domain K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 386.0
TLS3_k127_1803629_3 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 374.0
TLS3_k127_1803629_4 Belongs to the MtfA family K09933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008719 281.0
TLS3_k127_1803629_5 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000003645 187.0
TLS3_k127_1803629_6 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000008948 177.0
TLS3_k127_1803629_7 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000000000005041 133.0
TLS3_k127_1803629_8 Circularly permuted ATP-grasp type 2 - - - 0.00000000000000002211 86.0
TLS3_k127_1803629_9 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000001769 77.0
TLS3_k127_1810673_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 588.0
TLS3_k127_1810673_1 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007816 539.0
TLS3_k127_1810673_2 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 395.0
TLS3_k127_1810673_3 ThiF family K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 362.0
TLS3_k127_1810673_4 PFAM regulatory protein TetR K05501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006864 258.0
TLS3_k127_1810673_5 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003119 266.0
TLS3_k127_1815232_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 2.721e-246 769.0
TLS3_k127_1825270_0 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004141 502.0
TLS3_k127_1825270_1 Threonine synthase N terminus K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001259 279.0
TLS3_k127_1825270_2 PFAM molybdopterin biosynthesis MoaE K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000000000000000002442 228.0
TLS3_k127_1825270_3 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000000000000000000000000000000000000000000000003268 180.0
TLS3_k127_1825270_4 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000006359 121.0
TLS3_k127_1825270_5 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000000009784 102.0
TLS3_k127_1827443_0 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 566.0
TLS3_k127_1851003_0 Dynamin family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 580.0
TLS3_k127_1859740_0 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 413.0
TLS3_k127_1859740_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000005588 208.0
TLS3_k127_1859740_2 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.000000000000000000008631 93.0
TLS3_k127_1883430_0 general secretion pathway protein G K02456 - - 0.000000000000000000000000000000000000000000000005428 173.0
TLS3_k127_1883430_1 general secretion pathway protein K02457 - - 0.000000000000000000002579 102.0
TLS3_k127_1883430_2 General secretion pathway protein I K02458 - - 0.00000000000000000001245 97.0
TLS3_k127_1883430_3 general secretion pathway protein K02459 - - 0.00000000000001022 83.0
TLS3_k127_1883430_4 general secretion pathway protein K K02460 - - 0.0000003475 60.0
TLS3_k127_1888703_0 CoA-transferase family III - - - 2.638e-217 679.0
TLS3_k127_1888703_1 Acetyl-CoA acetyltransferase - - - 7.04e-201 631.0
TLS3_k127_1888703_2 ABC transporter K02028,K02029,K09972,K10004,K10010 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003729 286.0
TLS3_k127_1888703_3 Transcriptional regulator K02624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005711 256.0
TLS3_k127_1888703_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000911 263.0
TLS3_k127_1888703_5 belongs to the bacterial solute-binding protein 3 family K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009787 255.0
TLS3_k127_1888703_6 ABC-type amino acid transport system, permease component K02029 - - 0.00000000000000000000000000000000000000002338 160.0
TLS3_k127_1888703_7 Binding-protein-dependent transport system inner membrane component K02029 - - 0.00000000000000000000000000000000002715 151.0
TLS3_k127_1888703_8 PFAM 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.0000000006675 66.0
TLS3_k127_1888703_9 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0003852 45.0
TLS3_k127_1893437_0 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 513.0
TLS3_k127_1893437_1 fumarylacetoacetate (FAA) hydrolase K16171 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 505.0
TLS3_k127_1893437_2 PFAM L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 360.0
TLS3_k127_1893437_3 PFAM oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000922 355.0
TLS3_k127_1893437_4 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 333.0
TLS3_k127_1893437_5 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 332.0
TLS3_k127_1893437_6 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 302.0
TLS3_k127_1893437_7 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000005095 192.0
TLS3_k127_1893437_8 - - - - 0.0000000000000000000000006203 113.0
TLS3_k127_1893437_9 Protein of unknown function (DUF3108) - - - 0.00000000000000003205 93.0
TLS3_k127_1896810_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 4.281e-223 700.0
TLS3_k127_1896810_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002794 580.0
TLS3_k127_1896810_10 Elongation Factor G, domain II K02355 - - 0.000001612 50.0
TLS3_k127_1896810_2 PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 544.0
TLS3_k127_1896810_3 polyphosphate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 392.0
TLS3_k127_1896810_4 Transcriptional regulatory protein, C terminal K02483,K07666,K07774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 353.0
TLS3_k127_1896810_5 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001002 281.0
TLS3_k127_1896810_6 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000002754 256.0
TLS3_k127_1896810_7 Protein of unknown function (DUF2889) - - - 0.000000000000000000000000000000000000000000000000000000005139 204.0
TLS3_k127_1896810_8 Modulates RecA activity K03565 - - 0.0000000000000000000000000003325 123.0
TLS3_k127_1896810_9 Cold shock K03704 - - 0.000000000000000000000000001536 113.0
TLS3_k127_1918588_0 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 580.0
TLS3_k127_1918588_1 hydroxypyruvate reductase K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 513.0
TLS3_k127_1918588_2 ABC-type polar amino acid transport system, ATPase component K10004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 416.0
TLS3_k127_1918588_3 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 434.0
TLS3_k127_1918588_4 Extracellular solute-binding protein family 3 K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 324.0
TLS3_k127_1918588_5 Binding-protein-dependent transport system inner membrane component K10002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008127 323.0
TLS3_k127_1918588_6 Binding-protein-dependent transport system inner membrane component K02029,K10003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004439 319.0
TLS3_k127_1918588_7 Transketolase, thiamine diphosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000006337 239.0
TLS3_k127_1920240_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 561.0
TLS3_k127_1920240_1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 525.0
TLS3_k127_1920240_2 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004261 279.0
TLS3_k127_1920240_3 Nucleoside H+ symporter K05820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006041 254.0
TLS3_k127_1920240_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000000000000000000000242 216.0
TLS3_k127_1920240_5 Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers K06955 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000008952 216.0
TLS3_k127_1920240_6 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000008089 96.0
TLS3_k127_192111_0 D-amino acid K00285 - 1.4.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 505.0
TLS3_k127_192111_1 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 468.0
TLS3_k127_192111_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 448.0
TLS3_k127_192111_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000005923 207.0
TLS3_k127_192111_4 Cytochrome K08738 - - 0.0000000000000000000000000000006084 124.0
TLS3_k127_1929426_0 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 330.0
TLS3_k127_1929426_1 Peptidase family M23 K21472 - - 0.000000000000000000000000000000000000000000000000000000000000005243 221.0
TLS3_k127_1929426_2 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000003258 124.0
TLS3_k127_193468_0 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001017 261.0
TLS3_k127_193468_1 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000616 203.0
TLS3_k127_193468_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000000000000000000000002351 175.0
TLS3_k127_193468_3 MAPEG family - - - 0.000000000000000000000000000000000000009896 150.0
TLS3_k127_1945681_0 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 488.0
TLS3_k127_1945681_1 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006108 387.0
TLS3_k127_1945681_2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000006886 156.0
TLS3_k127_1945681_3 Lipopolysaccharide assembly protein A domain K08992 - - 0.00000000001153 70.0
TLS3_k127_1953152_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.978e-238 752.0
TLS3_k127_1953152_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008506 584.0
TLS3_k127_1953152_10 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.00000000000000000000000000001255 126.0
TLS3_k127_1953152_11 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine K00950 - 2.7.6.3 0.0000000000000000000000000005323 116.0
TLS3_k127_1953152_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 442.0
TLS3_k127_1953152_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 419.0
TLS3_k127_1953152_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006769 415.0
TLS3_k127_1953152_5 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 411.0
TLS3_k127_1953152_6 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 341.0
TLS3_k127_1953152_7 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 291.0
TLS3_k127_1953152_8 Cytochrome B561 - - - 0.00000000000000000000000000000000000000000000001259 181.0
TLS3_k127_1953152_9 PFAM Cytochrome C - - - 0.00000000000000000000000000000000000004858 148.0
TLS3_k127_1961822_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 611.0
TLS3_k127_1961822_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 586.0
TLS3_k127_1961822_2 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 569.0
TLS3_k127_1961822_3 UDP binding domain K02474 - - 0.000000000003325 68.0
TLS3_k127_1982871_0 ABC transporter transmembrane region K18889 - - 2.491e-239 757.0
TLS3_k127_1982871_1 ABC transporter transmembrane region K18890 - - 1.2e-228 728.0
TLS3_k127_1982871_2 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 309.0
TLS3_k127_1982871_3 periplasmic protein - - - 0.000000000000000000000000000000000000000000000000001023 203.0
TLS3_k127_1982871_4 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.000000000000000000000000000000000000000000000003256 184.0
TLS3_k127_1987080_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 7.99e-247 776.0
TLS3_k127_1987080_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000001943 253.0
TLS3_k127_1987080_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000001425 169.0
TLS3_k127_2008451_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.426e-277 863.0
TLS3_k127_2008451_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.733e-240 749.0
TLS3_k127_2008451_2 oligoketide cyclase lipid transport protein - - - 0.0000000000000000000000000000000000002213 146.0
TLS3_k127_2008451_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000002251 135.0
TLS3_k127_2008451_4 Domain of unknown function (DUF4124) - - - 0.000000000000000000002709 104.0
TLS3_k127_2008451_5 Belongs to the UPF0125 (RnfH) family K09801 - - 0.00000000000000002087 85.0
TLS3_k127_2008451_6 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000004302 63.0
TLS3_k127_2021306_0 Soluble lytic murein K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008781 294.0
TLS3_k127_2021306_1 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000000005921 179.0
TLS3_k127_2041688_0 Orn/Lys/Arg decarboxylase, C-terminal domain K01583 - 4.1.1.19 1.165e-268 834.0
TLS3_k127_2041688_1 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 421.0
TLS3_k127_2042280_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.801e-281 870.0
TLS3_k127_2042280_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 585.0
TLS3_k127_2042280_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000009467 140.0
TLS3_k127_2042280_3 membrane - - - 0.00000000000000000000000000006634 124.0
TLS3_k127_2042280_4 - - - - 0.000000000000004712 79.0
TLS3_k127_2072452_0 TIGRFAM TRAP dicarboxylate transporter, DctP subunit K21395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 473.0
TLS3_k127_2072452_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009707 271.0
TLS3_k127_2072452_2 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000005925 183.0
TLS3_k127_2072452_3 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000002016 177.0
TLS3_k127_2079927_0 TRAP transporter, 4TM 12TM fusion protein' - - - 1.33e-218 695.0
TLS3_k127_2079927_1 NMT1-like family K07080 - - 0.0000000000000000000000000004759 115.0
TLS3_k127_2079927_2 - - - - 0.000000000000000000989 89.0
TLS3_k127_2133829_0 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000108 249.0
TLS3_k127_2133829_1 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000478 112.0
TLS3_k127_2133829_2 Flagellar protein YcgR - - - 0.00000000000000007727 90.0
TLS3_k127_214510_0 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715,K07534 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 419.0
TLS3_k127_214510_1 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000001049 159.0
TLS3_k127_2198899_0 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 340.0
TLS3_k127_2198899_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006068 272.0
TLS3_k127_2198899_2 Periplasmic binding protein K02016,K06858 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001736 268.0
TLS3_k127_2198899_3 Biopolymer transport K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002002 257.0
TLS3_k127_2198899_4 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000002101 172.0
TLS3_k127_2198899_5 Biopolymer transport protein, ExbD K03559 - - 0.00000000000000000000000000000000002388 149.0
TLS3_k127_220072_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007632 335.0
TLS3_k127_220072_1 molybdopterin K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000003916 207.0
TLS3_k127_220072_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000012 162.0
TLS3_k127_2202716_0 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 334.0
TLS3_k127_2202716_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 303.0
TLS3_k127_2202716_2 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 298.0
TLS3_k127_2205603_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 395.0
TLS3_k127_2205603_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K03601,K04564 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 360.0
TLS3_k127_2205603_2 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000009325 172.0
TLS3_k127_2205603_3 Isocitrate/isopropylmalate dehydrogenase K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 0.0000000000000000008615 86.0
TLS3_k127_2205603_4 MotA/TolQ/ExbB proton channel family K03561 - - 0.0000000000003683 70.0
TLS3_k127_2213150_0 PGAP1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 399.0
TLS3_k127_2213150_1 - - - - 0.0000000000002415 73.0
TLS3_k127_2213150_2 Response regulator receiver - - - 0.0000004489 52.0
TLS3_k127_2218178_0 PFAM Inner membrane CreD family protein K06143 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 426.0
TLS3_k127_2218178_1 Permease YjgP YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 355.0
TLS3_k127_2218178_2 Permease YjgP YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 343.0
TLS3_k127_2218178_3 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 315.0
TLS3_k127_2218178_4 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000000000000000000000000001633 134.0
TLS3_k127_2218178_5 - - - - 0.0000000000000000000000000000003863 124.0
TLS3_k127_2238358_0 Homoserine dehydrogenase, NAD binding domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009227 604.0
TLS3_k127_2238358_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 475.0
TLS3_k127_228_0 Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 537.0
TLS3_k127_228_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03669 - - 0.000000000000000000000000000000000000000000000000000000000000000004415 235.0
TLS3_k127_228097_0 ribonuclease, Rne Rng family K08301 - - 1.521e-225 709.0
TLS3_k127_228097_1 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009411 478.0
TLS3_k127_228097_2 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005537 277.0
TLS3_k127_228097_3 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000007116 225.0
TLS3_k127_228097_4 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000000000000000005504 189.0
TLS3_k127_228097_5 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000000005692 171.0
TLS3_k127_228097_6 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000003818 162.0
TLS3_k127_2320370_0 COG0339 Zn-dependent oligopeptidases K01284 GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.5 6.537e-210 668.0
TLS3_k127_2325590_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 544.0
TLS3_k127_2325590_1 von Willebrand factor type A domain K07114 - - 0.00000000000000000000000001483 120.0
TLS3_k127_2333938_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 537.0
TLS3_k127_2333938_1 demethylmenaquinone methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 360.0
TLS3_k127_2333938_2 Belongs to the DapA family K01714 - 4.3.3.7 0.000000000000000000000000000122 115.0
TLS3_k127_2341215_0 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 612.0
TLS3_k127_2341215_1 Transcriptional regulator, LysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 326.0
TLS3_k127_2341215_2 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005225 248.0
TLS3_k127_2341215_3 PFAM Patatin K07001 - - 0.0000000000000000000000001319 109.0
TLS3_k127_2392593_0 helicase K03722 - 3.6.4.12 4.12e-196 632.0
TLS3_k127_2392593_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 348.0
TLS3_k127_2392593_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005834 285.0
TLS3_k127_2392593_3 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000008869 233.0
TLS3_k127_2392593_4 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000002393 102.0
TLS3_k127_2392593_5 Protein of unknown function (DUF465) - - - 0.00000000009717 64.0
TLS3_k127_240145_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 538.0
TLS3_k127_240145_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 336.0
TLS3_k127_2418173_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007645 379.0
TLS3_k127_2418173_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 369.0
TLS3_k127_2418173_2 helix_turn_helix, Lux Regulon K13041 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 295.0
TLS3_k127_2418173_3 Peptidase family M3 K01414 - 3.4.24.70 0.000000000000000000000000000000000000000000000000000000137 199.0
TLS3_k127_245385_0 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005349 259.0
TLS3_k127_245385_1 2-phosphosulfolactate phosphatase activity K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.0000000000000000000000000000000000000000000000000000000006517 209.0
TLS3_k127_2485683_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 4.609e-207 653.0
TLS3_k127_2485683_1 His Kinase A (phosphoacceptor) domain - - - 1.236e-205 678.0
TLS3_k127_2485683_2 TRAP transporter solute receptor, TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 450.0
TLS3_k127_2485683_3 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 438.0
TLS3_k127_2485683_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 418.0
TLS3_k127_2485683_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 321.0
TLS3_k127_2485683_6 Transcriptional regulatory protein, C terminal K07659 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009442 298.0
TLS3_k127_2485683_7 cytochrome c5 - - - 0.000000000000000000000000000000000000000000006231 177.0
TLS3_k127_2485683_8 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000007143 156.0
TLS3_k127_2485683_9 - - - - 0.00000008285 55.0
TLS3_k127_2493707_0 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 466.0
TLS3_k127_2493707_1 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000918 339.0
TLS3_k127_2498762_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000002405 183.0
TLS3_k127_2498762_1 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000478 166.0
TLS3_k127_2498762_2 PFAM GYD family protein - - - 0.00000000000000000000000000003905 121.0
TLS3_k127_2498762_3 Cold shock protein K03704 - - 0.0000002859 51.0
TLS3_k127_2552851_0 Belongs to the DapB family K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 360.0
TLS3_k127_2552851_1 2-Keto-4-pentenoate hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 320.0
TLS3_k127_2552851_2 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000000000000004115 164.0
TLS3_k127_2552851_3 acetyltransferase - - - 0.000000000000000000000000000000000000000001399 168.0
TLS3_k127_2552851_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000009872 152.0
TLS3_k127_2552851_5 - - - - 0.000000000000000000000000000001195 134.0
TLS3_k127_2552851_6 Bacterial PH domain - - - 0.00000000000000000000000001586 117.0
TLS3_k127_2552851_7 - - - - 0.00000000000000000000005738 104.0
TLS3_k127_25631_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 530.0
TLS3_k127_25631_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001047 267.0
TLS3_k127_25631_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000001315 237.0
TLS3_k127_2585721_0 Domain of unknown function (DUF4131) K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 333.0
TLS3_k127_2585721_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 295.0
TLS3_k127_2585721_2 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001403 279.0
TLS3_k127_2585721_3 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003504 246.0
TLS3_k127_2585721_4 protein conserved in bacteria K09928 - - 0.00000000000000000000000000000000000000000000000000003427 192.0
TLS3_k127_2587451_0 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K02660 - - 2.894e-215 693.0
TLS3_k127_2587451_1 Histidine kinase K02487,K06596 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 469.0
TLS3_k127_2587451_2 cheY-homologous receiver domain K02657 - - 0.000000000000000000000000000000000000000000000000000000000007056 212.0
TLS3_k127_2587451_3 cheY-homologous receiver domain K02658 - - 0.000000000000000000000000000000000000000000000000000000254 196.0
TLS3_k127_2587451_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000008444 166.0
TLS3_k127_2587451_5 Rubredoxin - - - 0.000000000000000000000000000003926 120.0
TLS3_k127_2587451_6 Two component signalling adaptor domain K02659 - - 0.000000000000000000000000000086 122.0
TLS3_k127_2587451_7 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway K01845 - 5.4.3.8 0.000000000000000002814 85.0
TLS3_k127_2594335_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 534.0
TLS3_k127_2594335_1 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 475.0
TLS3_k127_2594335_2 GntR family transcriptional regulator K03710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 339.0
TLS3_k127_2594335_3 Belongs to the citrate synthase family K01659 - 2.3.3.5 0.000000005139 57.0
TLS3_k127_2609572_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 498.0
TLS3_k127_2609572_1 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000004537 236.0
TLS3_k127_2610507_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 4.001e-199 632.0
TLS3_k127_2610507_1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K03825 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 - 0.0000000000000000000000000000002934 127.0
TLS3_k127_2615955_0 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides K00364 - 1.7.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 542.0
TLS3_k127_2615955_1 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 372.0
TLS3_k127_2615955_2 PFAM cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000001214 235.0
TLS3_k127_2615955_3 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000000000000001033 231.0
TLS3_k127_2615955_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000002368 227.0
TLS3_k127_2617819_0 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000003538 214.0
TLS3_k127_2617819_1 3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein) - - - 0.00000000000102 75.0
TLS3_k127_2617819_2 AMP-binding enzyme - - - 0.00000000001205 67.0
TLS3_k127_2617819_3 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000555 63.0
TLS3_k127_2620287_0 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 492.0
TLS3_k127_2620287_1 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 301.0
TLS3_k127_2620287_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000437 142.0
TLS3_k127_2623825_0 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 436.0
TLS3_k127_2623825_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000001028 179.0
TLS3_k127_2633706_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 3.491e-198 623.0
TLS3_k127_2633706_1 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 494.0
TLS3_k127_264156_0 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 319.0
TLS3_k127_264156_1 Diguanylate cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000001779 179.0
TLS3_k127_264156_2 Histidine kinase - - - 0.0000000000000002009 84.0
TLS3_k127_2644647_0 Aminotransferase K14261 - - 4.67e-220 689.0
TLS3_k127_2644647_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 610.0
TLS3_k127_2644647_2 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 390.0
TLS3_k127_2644647_3 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001872 257.0
TLS3_k127_2644647_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000005646 227.0
TLS3_k127_2644647_5 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000000000000000001581 153.0
TLS3_k127_2644711_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 504.0
TLS3_k127_2644711_1 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 389.0
TLS3_k127_2644711_2 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000004467 217.0
TLS3_k127_2647643_0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 366.0
TLS3_k127_2647643_1 FR47-like protein - - - 0.000000000000000000000000000000000000000000000000000129 196.0
TLS3_k127_2650844_0 Bacterial periplasmic substrate-binding proteins K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003596 287.0
TLS3_k127_2650844_1 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004302 268.0
TLS3_k127_2650844_2 amino acid ABC transporter K02029 - - 0.0000000000000000000000005607 106.0
TLS3_k127_2656938_0 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008178 608.0
TLS3_k127_2656938_1 3-hydroxyacyl-coa dehydrogenase K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 547.0
TLS3_k127_2656938_2 Limonene-1,2-epoxide hydrolase catalytic domain - - - 0.0000000000000000000000000000000000001581 146.0
TLS3_k127_2656938_3 Enoyl-CoA hydratase - - - 0.0001734 48.0
TLS3_k127_2657785_0 Short chain fatty acid transporter K02106 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 603.0
TLS3_k127_2657785_1 Efflux transporter, outer membrane factor lipoprotein, NodT family K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 336.0
TLS3_k127_2657785_2 efflux pump K18138,K18146 - - 0.000000000000000000000000000000000000000000000000000000000000000000644 232.0
TLS3_k127_2657785_3 DsrE/DsrF-like family K09004 - - 0.00000000000000000000000000000000000003611 149.0
TLS3_k127_2657785_4 NUDIX domain - - - 0.0000000000000000000002625 99.0
TLS3_k127_2682009_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019058,GO:0019068,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0044183,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0061077,GO:0097159,GO:0097367,GO:0101031,GO:1901265,GO:1901363,GO:1990220 - 0.0000000000000000000000000000000000000000000000499 169.0
TLS3_k127_2682009_1 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000000000000001214 165.0
TLS3_k127_2682009_2 CRISPR system CASCADE complex protein CasE K19126 - - 0.0001485 52.0
TLS3_k127_2689894_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 525.0
TLS3_k127_2689894_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007558 336.0
TLS3_k127_2689894_2 Belongs to the frataxin family K06202 - - 0.00000000000000000000000000008382 118.0
TLS3_k127_269163_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005345 580.0
TLS3_k127_269163_1 formate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 311.0
TLS3_k127_269163_2 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004786 276.0
TLS3_k127_269163_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001283 263.0
TLS3_k127_269163_4 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000003781 194.0
TLS3_k127_269163_5 NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.0000000000000000000000000000000000000000000000002724 188.0
TLS3_k127_2705799_0 helicase superfamily c-terminal domain K03724 - - 0.0 1017.0
TLS3_k127_2705799_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 3.945e-306 947.0
TLS3_k127_2705799_10 PFAM SWIB MDM2 domain protein - - - 0.0000000000000000000000000000000000002249 146.0
TLS3_k127_2705799_11 - - - - 0.00000000000000000006276 92.0
TLS3_k127_2705799_2 Catalyzes the ATP-dependent formation of a phosphodiester at the site of a single strand break in duplex DNA K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 6.044e-217 685.0
TLS3_k127_2705799_3 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 609.0
TLS3_k127_2705799_4 Exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 492.0
TLS3_k127_2705799_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 425.0
TLS3_k127_2705799_6 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 388.0
TLS3_k127_2705799_7 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005275 266.0
TLS3_k127_2705799_8 RES - - - 0.0000000000000000000000000000000000000000003803 162.0
TLS3_k127_2705799_9 PFAM NUDIX hydrolase K08310 - 3.6.1.67 0.0000000000000000000000000000000000000000009221 162.0
TLS3_k127_2707107_0 UDP-galactopyranose mutase K01854 - 5.4.99.9 5.969e-208 653.0
TLS3_k127_2707107_1 Ureidoglycolate lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004001 359.0
TLS3_k127_2707107_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 319.0
TLS3_k127_2707107_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 325.0
TLS3_k127_2707107_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 298.0
TLS3_k127_2707107_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002195 231.0
TLS3_k127_2707107_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000002958 207.0
TLS3_k127_2707107_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000009203 57.0
TLS3_k127_2707696_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.596e-249 774.0
TLS3_k127_2707696_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 4.115e-226 705.0
TLS3_k127_2707696_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 339.0
TLS3_k127_2707696_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000002833 201.0
TLS3_k127_2732631_0 E3 component of 2-oxoglutarate dehydrogenase complex K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 7.015e-230 719.0
TLS3_k127_2732631_1 AFG1-like ATPase K06916 - - 0.00000000000000000000000000000000000000000000000000000000000000000001619 234.0
TLS3_k127_2732631_2 PspC domain - - - 0.0000000000000001177 80.0
TLS3_k127_274563_0 type I phosphodiesterase nucleotide pyrophosphatase K19670 - 3.11.1.2 1.243e-194 614.0
TLS3_k127_274563_1 belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 524.0
TLS3_k127_274563_2 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005479 239.0
TLS3_k127_2757782_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 530.0
TLS3_k127_2757782_1 ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 391.0
TLS3_k127_2757782_2 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000007472 259.0
TLS3_k127_2757782_3 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.000000000000000000000000000000000000000000000000000000000607 207.0
TLS3_k127_2757782_4 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.00000000000000000000000000000000000002034 153.0
TLS3_k127_2757782_5 seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing K05808 - - 0.0000000000000000000000000000002098 132.0
TLS3_k127_2757782_6 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000000000000000000000000046 121.0
TLS3_k127_2757782_7 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000007525 49.0
TLS3_k127_2775836_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 4.754e-236 754.0
TLS3_k127_2775836_1 LysR family K04761 - - 0.000000000000000000000000000000000000000000000000003759 190.0
TLS3_k127_2775836_2 endoribonuclease K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000002625 168.0
TLS3_k127_27896_0 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008644 450.0
TLS3_k127_27896_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008289 388.0
TLS3_k127_27896_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 347.0
TLS3_k127_27896_3 AMP-binding enzyme C-terminal domain K18661 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007397 345.0
TLS3_k127_27896_4 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000281 252.0
TLS3_k127_2795944_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009655 396.0
TLS3_k127_2795944_1 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 345.0
TLS3_k127_2795944_10 - - - - 0.00000000009101 70.0
TLS3_k127_2795944_2 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 308.0
TLS3_k127_2795944_3 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005033 271.0
TLS3_k127_2795944_4 PFAM VanZ family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001192 274.0
TLS3_k127_2795944_5 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000004217 263.0
TLS3_k127_2795944_6 Serine aminopeptidase, S33 K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000002935 232.0
TLS3_k127_2795944_7 Ferredoxin - - - 0.000000000000000000000000000000000000000002223 162.0
TLS3_k127_2795944_8 Belongs to the UPF0250 family K09158 - - 0.00000000000000000000000000000004175 127.0
TLS3_k127_2795944_9 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000000000000000003757 113.0
TLS3_k127_2798212_0 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 442.0
TLS3_k127_2798212_1 short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 370.0
TLS3_k127_2798212_2 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000000000000000000000000000000000001726 164.0
TLS3_k127_2804643_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 8.326e-252 794.0
TLS3_k127_2804643_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 466.0
TLS3_k127_2804643_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000002371 155.0
TLS3_k127_2804643_3 Nitrous oxide-stimulated promoter - - - 0.00000000000000000000000000000157 127.0
TLS3_k127_2813451_0 PFAM Pyruvate carboxyltransferase K01640 GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 425.0
TLS3_k127_2813451_1 d-isomer specific 2-hydroxyacid dehydrogenase, nad-binding K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 299.0
TLS3_k127_2813451_2 type 4 fimbrial biogenesis K02672 - - 0.0000000000000000000000000000000000000000000000003546 189.0
TLS3_k127_2813451_3 type IV pilus modification protein PilV - - - 0.000000000000000000000000000000000007733 143.0
TLS3_k127_2813451_4 Type IV pilus assembly protein PilE K02655 - - 0.0000000000000000000000000000006137 130.0
TLS3_k127_2813451_5 carboxylase K01965,K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.3,6.4.1.4 0.000000000000000000000000001634 113.0
TLS3_k127_2813451_6 Pilus assembly protein PilX - - - 0.0000000000000000000004411 110.0
TLS3_k127_2813451_7 Type II transport protein GspH K08084 - - 0.00000000000000000002022 97.0
TLS3_k127_2813451_8 Neisseria PilC beta-propeller domain K02674 - - 0.0000000002001 66.0
TLS3_k127_2820845_0 Zinc-binding dehydrogenase K19745 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 424.0
TLS3_k127_2820845_1 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 412.0
TLS3_k127_2820845_2 PFAM EAL domain, GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000959 364.0
TLS3_k127_2820845_3 Flavin containing amine oxidoreductase K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 347.0
TLS3_k127_2820845_4 amino acid K03294,K19540 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003826 284.0
TLS3_k127_2820845_5 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000971 270.0
TLS3_k127_2820845_6 Protein of unknown function (DUF3429) - - - 0.000000000000385 76.0
TLS3_k127_2827595_0 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 333.0
TLS3_k127_2827595_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000001854 156.0
TLS3_k127_2827595_2 - - - - 0.0000000000000000000000000000000000001233 151.0
TLS3_k127_2827595_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000005179 100.0
TLS3_k127_2830533_0 Belongs to the peptidase S8 family K14645 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 326.0
TLS3_k127_2830533_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002033 269.0
TLS3_k127_2830533_2 membrane protein (homolog of Drosophila rhomboid) - - - 0.0000004804 57.0
TLS3_k127_2835702_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 3.546e-196 623.0
TLS3_k127_2835702_1 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000001562 184.0
TLS3_k127_2842889_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 3.043e-225 715.0
TLS3_k127_2842889_1 Tartrate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 1.086e-210 658.0
TLS3_k127_2842889_2 TRAP transporter solute receptor TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 402.0
TLS3_k127_2842889_3 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 401.0
TLS3_k127_2856446_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008279 456.0
TLS3_k127_2856446_1 phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 400.0
TLS3_k127_2856446_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 325.0
TLS3_k127_2856446_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000003493 244.0
TLS3_k127_2856446_4 lipase activity - - - 0.000000000000000000000000000000000000000000000000000000294 205.0
TLS3_k127_2856446_5 Sodium calcium - - - 0.0000000000000000000000001641 108.0
TLS3_k127_2863572_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 307.0
TLS3_k127_2863572_1 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 303.0
TLS3_k127_2863572_2 Ribosomal RNA adenine dimethylases K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002571 281.0
TLS3_k127_2863572_3 Metal-dependent hydrolase K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000001663 243.0
TLS3_k127_2863572_4 Lactoylglutathione lyase K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000002482 216.0
TLS3_k127_2863572_5 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000006218 78.0
TLS3_k127_2868968_0 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 434.0
TLS3_k127_2868968_1 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000001044 234.0
TLS3_k127_2868968_2 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000005807 168.0
TLS3_k127_2882595_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.89e-197 631.0
TLS3_k127_2882595_1 PFAM peptidase M3A and M3B thimet oligopeptidase F K01414 - 3.4.24.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 515.0
TLS3_k127_2882595_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000006205 225.0
TLS3_k127_2882595_3 Domain of unknown function (DUF4124) - - - 0.0000000000000000000000000000000004647 137.0
TLS3_k127_2882595_4 PFAM Glutaredoxin - - - 0.0000000000000000000000000000006141 131.0
TLS3_k127_2882595_5 BRO family, N-terminal domain K07741 - - 0.000009139 55.0
TLS3_k127_2883897_0 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 575.0
TLS3_k127_2883897_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 436.0
TLS3_k127_2883897_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005462 254.0
TLS3_k127_2883897_3 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000001316 195.0
TLS3_k127_2883897_4 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000002958 99.0
TLS3_k127_2893305_0 general secretion pathway protein D K02453 - - 2.138e-194 626.0
TLS3_k127_2893305_1 General Secretory Pathway K02463 - - 0.0000002514 55.0
TLS3_k127_2939226_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 417.0
TLS3_k127_2939226_1 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 311.0
TLS3_k127_2939226_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001638 267.0
TLS3_k127_2976785_0 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00347 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 490.0
TLS3_k127_2976785_1 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 476.0
TLS3_k127_2976785_2 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00349 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000002371 261.0
TLS3_k127_2976785_3 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00348 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000001055 219.0
TLS3_k127_2976785_4 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00350 - 1.6.5.8 0.0000000000000000000000000000000000000000000003939 169.0
TLS3_k127_2976785_5 Ferredoxin K05337 - - 0.000000000000000000000000000000005689 129.0
TLS3_k127_2993702_0 Belongs to the UPF0061 (SELO) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 590.0
TLS3_k127_2993702_1 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000004045 114.0
TLS3_k127_2993702_2 AMP-binding enzyme C-terminal domain K20034 - 6.2.1.44 0.00003019 51.0
TLS3_k127_3010072_0 o-acetylhomoserine K01740 - 2.5.1.49 2.892e-218 685.0
TLS3_k127_3010072_1 PFAM FAD binding domain, FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 582.0
TLS3_k127_3010072_2 UPF0761 membrane protein K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 317.0
TLS3_k127_3010072_3 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008362 282.0
TLS3_k127_3010072_4 Belongs to the WrbA family K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009881 271.0
TLS3_k127_3010072_5 membrane - - - 0.00000000000000000000002722 104.0
TLS3_k127_3010072_6 - - - - 0.000000000000000004109 94.0
TLS3_k127_3023254_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 434.0
TLS3_k127_3023254_1 AAA domain K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 401.0
TLS3_k127_3023254_2 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 293.0
TLS3_k127_3023254_3 3-demethylubiquinone-9 3-methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000002397 238.0
TLS3_k127_3023254_4 AzlC protein - - - 0.0000000000000000000000000000000000000000339 164.0
TLS3_k127_3023254_5 (Lipo)protein - - - 0.00000000000000000000000008615 111.0
TLS3_k127_3023254_6 Branched-chain amino acid transport protein (AzlD) - - - 0.00000000000000000005268 93.0
TLS3_k127_3067977_0 PFAM type I phosphodiesterase nucleotide pyrophosphatase K19670 - 3.11.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 615.0
TLS3_k127_3067977_1 TIGRFAM 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 491.0
TLS3_k127_3067977_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 468.0
TLS3_k127_3067977_3 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006922 340.0
TLS3_k127_3067977_4 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 293.0
TLS3_k127_3067977_5 permease K02011 - - 0.000000000000000000000000000000000005386 146.0
TLS3_k127_3072941_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 584.0
TLS3_k127_3072941_1 COG0457 FOG TPR repeat - - - 0.00009971 50.0
TLS3_k127_3081285_0 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 0.0 1083.0
TLS3_k127_3081285_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 488.0
TLS3_k127_3081285_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000000123 181.0
TLS3_k127_3081285_3 sister chromatid segregation - - - 0.00000000000000000000000000000004118 134.0
TLS3_k127_319492_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 585.0
TLS3_k127_319492_1 COG1226 Kef-type K transport systems K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005951 248.0
TLS3_k127_319492_2 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000646 231.0
TLS3_k127_319492_3 - - - - 0.000000000000002489 79.0
TLS3_k127_319492_4 Rho termination factor, N-terminal domain - - - 0.000000000414 61.0
TLS3_k127_319706_0 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.903e-214 679.0
TLS3_k127_319706_1 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 596.0
TLS3_k127_319706_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 458.0
TLS3_k127_319706_3 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 381.0
TLS3_k127_319706_4 ABC-type Fe3 transport system permease component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 377.0
TLS3_k127_319706_5 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.00000000000000001193 85.0
TLS3_k127_320365_0 Mo-co oxidoreductase dimerisation domain K17225 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 335.0
TLS3_k127_320365_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000008395 151.0
TLS3_k127_320365_2 PFAM CBS domain containing protein - - - 0.0000000000000000000001921 103.0
TLS3_k127_3268603_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007666 469.0
TLS3_k127_3268603_1 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.0000000000000000003599 89.0
TLS3_k127_3279596_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 545.0
TLS3_k127_3279596_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000144 277.0
TLS3_k127_3279596_2 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000002095 184.0
TLS3_k127_3279596_3 protein conserved in bacteria - - - 0.00008544 47.0
TLS3_k127_3283337_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.748e-195 618.0
TLS3_k127_3283337_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 497.0
TLS3_k127_3283337_2 membrane - - - 0.00000000000000001884 91.0
TLS3_k127_3283337_3 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit K21393 - - 0.00000000001938 64.0
TLS3_k127_3302152_0 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 457.0
TLS3_k127_3302152_1 Proton-conducting membrane transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006657 252.0
TLS3_k127_3399152_0 ABC-type sugar transport system, periplasmic component K05813 - - 1.469e-236 739.0
TLS3_k127_3399152_1 ATPases associated with a variety of cellular activities K05816,K10111,K10112 - 3.6.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 490.0
TLS3_k127_3399152_10 Pilus retraction K02669,K12203 - - 0.000000000000000000000003579 104.0
TLS3_k127_3399152_2 PFAM binding-protein-dependent transport systems inner membrane component K05814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 468.0
TLS3_k127_3399152_3 probably responsible for the translocation of the substrate across the membrane K02026,K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005724 454.0
TLS3_k127_3399152_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 352.0
TLS3_k127_3399152_5 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 338.0
TLS3_k127_3399152_6 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002381 277.0
TLS3_k127_3399152_7 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000002439 263.0
TLS3_k127_3399152_8 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000000008665 219.0
TLS3_k127_3399152_9 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.00000000000000000000000000000001222 136.0
TLS3_k127_340337_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 9.639e-230 713.0
TLS3_k127_340337_1 CoA-transferase family III K18289 - 2.8.3.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003436 594.0
TLS3_k127_340337_2 N-terminal half of MaoC dehydratase K09709,K18291 - 4.2.1.153,4.2.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 320.0
TLS3_k127_340337_3 MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000004682 237.0
TLS3_k127_340337_4 (GMC) oxidoreductase K00108 - 1.1.99.1 0.0000000000001466 70.0
TLS3_k127_3452111_0 Elongation factor SelB, winged helix - - - 0.0000000000000000000000000000000000000000005335 161.0
TLS3_k127_3452111_1 DsrE/DsrF-like family - - - 0.00000000000000000001018 96.0
TLS3_k127_3452111_2 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000001962 90.0
TLS3_k127_3452111_3 Translation elongation factor K03833 GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 - 0.000008958 57.0
TLS3_k127_3452596_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.065e-282 874.0
TLS3_k127_3452596_1 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 362.0
TLS3_k127_3452596_2 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 331.0
TLS3_k127_3452596_3 Domain of unknown function (DUF4845) - - - 0.000000000000000000000074 102.0
TLS3_k127_3455856_0 Bifunctional enoyl-CoA hydratase phosphate acetyltransferase K00625,K00634 - 2.3.1.19,2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 524.0
TLS3_k127_3455856_1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 316.0
TLS3_k127_3466360_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02504,K02652 - - 1.859e-249 781.0
TLS3_k127_3466360_1 type II secretion system protein K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 564.0
TLS3_k127_3466360_2 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 454.0
TLS3_k127_3466360_3 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 394.0
TLS3_k127_3466360_4 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 354.0
TLS3_k127_3466360_5 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000000000001145 199.0
TLS3_k127_3466360_6 dephospho-CoA kinase activity - - - 0.0000000000001051 72.0
TLS3_k127_3466360_7 - - - - 0.000134 44.0
TLS3_k127_3474032_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 475.0
TLS3_k127_3474032_1 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000001388 173.0
TLS3_k127_3474032_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.000000000000006638 75.0
TLS3_k127_3492972_0 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 2.235e-242 755.0
TLS3_k127_3492972_1 ABC transporter K02065 - - 0.00000000000000005802 83.0
TLS3_k127_3495755_0 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 480.0
TLS3_k127_3495755_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 449.0
TLS3_k127_3495755_2 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000462 257.0
TLS3_k127_3495755_3 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000416 236.0
TLS3_k127_3495755_4 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000004404 184.0
TLS3_k127_3495755_5 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.000000000000000000005291 94.0
TLS3_k127_3501052_0 ABC-type phosphate phosphonate transport system permease component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 390.0
TLS3_k127_3501052_1 ABC-type phosphate phosphonate transport system permease component K02042 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 348.0
TLS3_k127_3501052_2 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 331.0
TLS3_k127_3521083_0 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 391.0
TLS3_k127_3521083_1 cytochrome c oxidase, cbb3-type, subunit II K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 338.0
TLS3_k127_3521083_2 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.00000000000000000000000000000000000000000000000001318 181.0
TLS3_k127_3521083_3 Cbb3-type cytochrome oxidase K00407 - - 0.00000001782 63.0
TLS3_k127_3524428_0 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 1.088e-198 628.0
TLS3_k127_3524428_1 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 476.0
TLS3_k127_3524428_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 398.0
TLS3_k127_3524428_3 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244,K19743 - 1.4.1.1,1.5.1.1,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 347.0
TLS3_k127_3524428_4 Chromate resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 294.0
TLS3_k127_3524428_5 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000000000000000000000000000000008255 184.0
TLS3_k127_3524428_6 PFAM Glutathione S-transferase domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000838 187.0
TLS3_k127_3524428_7 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000004829 159.0
TLS3_k127_3533432_0 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 430.0
TLS3_k127_3533432_1 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000000009651 221.0
TLS3_k127_3540021_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 601.0
TLS3_k127_3540021_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 339.0
TLS3_k127_3540021_2 Forms part of the polypeptide exit tunnel K02926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003113 257.0
TLS3_k127_3540021_3 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000001337 193.0
TLS3_k127_3550356_0 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 593.0
TLS3_k127_3550356_1 Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5- (5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 415.0
TLS3_k127_3550356_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.0000000000000000000000000000000000003524 147.0
TLS3_k127_3550356_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000000003354 97.0
TLS3_k127_3550356_12 Histidine biosynthesis bifunctional protein hisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000265 95.0
TLS3_k127_3550356_13 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000001267 85.0
TLS3_k127_3550356_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 409.0
TLS3_k127_3550356_3 Thioredoxin-like K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 355.0
TLS3_k127_3550356_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005415 333.0
TLS3_k127_3550356_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 302.0
TLS3_k127_3550356_6 Belongs to the peptidase S1C family K04691,K04772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002655 266.0
TLS3_k127_3550356_7 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000000001632 192.0
TLS3_k127_3550356_8 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000000000000000000265 181.0
TLS3_k127_3550356_9 Psort location Extracellular, score K07126 - - 0.0000000000000000000000000000000000000000000001181 175.0
TLS3_k127_3556136_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1086.0
TLS3_k127_3577815_0 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K04652 GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010467,GO:0016151,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 374.0
TLS3_k127_3577815_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0000000000000000000000000000000000000000000002729 171.0
TLS3_k127_3577815_2 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000003531 138.0
TLS3_k127_3577815_3 Nickel-dependent hydrogenase - - - 0.000000000000001298 80.0
TLS3_k127_359827_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000665 354.0
TLS3_k127_359827_1 Lecithin:cholesterol acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006279 284.0
TLS3_k127_359827_2 Peptidoglycan-binding domain 1 protein K02450,K03791,K17733 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000943 283.0
TLS3_k127_3603328_0 Carbohydrate phosphorylase K00688,K16153 - 2.4.1.1,2.4.1.11 2.463e-213 677.0
TLS3_k127_3603328_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 495.0
TLS3_k127_3603328_2 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 398.0
TLS3_k127_3603328_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 305.0
TLS3_k127_3603328_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000001889 203.0
TLS3_k127_3603328_5 peptidase S1 and S6, chymotrypsin Hap - - - 0.00000000000001022 83.0
TLS3_k127_3604300_0 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 591.0
TLS3_k127_3604300_1 DinB family - - - 0.0000000000000000000000000000000000000000000000000004107 194.0
TLS3_k127_3604300_2 Belongs to the ABC transporter superfamily K02031,K16202 - - 0.0000000000001051 72.0
TLS3_k127_3607946_0 Phosphoenolpyruvate hydrolase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 455.0
TLS3_k127_3607946_1 Flotillin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 390.0
TLS3_k127_3626684_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1746.0
TLS3_k127_3626684_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 8.513e-257 816.0
TLS3_k127_3626684_2 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 442.0
TLS3_k127_3626684_3 DNA polymerase III, epsilon subunit K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 389.0
TLS3_k127_3626684_4 Hydrolases of the alpha beta superfamily K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005668 325.0
TLS3_k127_3626684_5 Nuclear protein SET K07117 - - 0.0000000000000000000000000000000000000000000000000000000000958 209.0
TLS3_k127_3626684_6 Domain of unknown function (DUF1993) K09983 - - 0.000000000000000000000000000000000000000000000000000000007723 207.0
TLS3_k127_3626684_7 - - - - 0.0000000000000000000000000000000000000001977 162.0
TLS3_k127_3626684_8 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000005807 166.0
TLS3_k127_3626684_9 Sigma-70, region 4 K03088 - - 0.000000003721 57.0
TLS3_k127_3636341_0 DNA helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 332.0
TLS3_k127_3636341_1 AsmA family K07289,K07290 - - 0.0000000000000000000000000003996 123.0
TLS3_k127_3636341_2 - - - - 0.0000002088 55.0
TLS3_k127_3639421_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001895 276.0
TLS3_k127_3642139_0 PFAM aminotransferase class I and II K00832 - 2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 574.0
TLS3_k127_3642139_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 334.0
TLS3_k127_3642139_2 HNH nucleases - - - 0.00000000000000000000000000000000000000000000001738 181.0
TLS3_k127_3642139_3 phosphoglycerate mutase - - - 0.0000000000000000000000000000001297 131.0
TLS3_k127_3649256_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 340.0
TLS3_k127_3649256_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 297.0
TLS3_k127_3649261_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 341.0
TLS3_k127_3649261_1 Alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 319.0
TLS3_k127_3649261_10 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.000000000000000000000000000000000000000000000000000000000000834 218.0
TLS3_k127_3649261_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K04756 - - 0.000000000000000000000000000000000000000000000000000000000001071 214.0
TLS3_k127_3649261_12 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000002473 182.0
TLS3_k127_3649261_13 PFAM Hemerythrin HHE cation binding domain protein K07216 - - 0.00003529 49.0
TLS3_k127_3649261_2 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 317.0
TLS3_k127_3649261_3 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 319.0
TLS3_k127_3649261_4 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 297.0
TLS3_k127_3649261_5 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 297.0
TLS3_k127_3649261_6 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001517 282.0
TLS3_k127_3649261_7 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 K22132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002206 265.0
TLS3_k127_3649261_8 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000172 242.0
TLS3_k127_3649261_9 of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000002313 229.0
TLS3_k127_3664675_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003261 261.0
TLS3_k127_3664675_1 PFAM HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000003718 185.0
TLS3_k127_3664675_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000005791 111.0
TLS3_k127_3664675_3 B12 binding domain - - - 0.000000000000000000000009157 104.0
TLS3_k127_3667366_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 2.48e-231 724.0
TLS3_k127_3667366_1 single-stranded-DNA-specific exonuclease RecJ K07462 - - 1.646e-210 668.0
TLS3_k127_3667366_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 535.0
TLS3_k127_3667366_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001442 269.0
TLS3_k127_3667366_4 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.000000000000000000000000000000000000000001984 163.0
TLS3_k127_3667366_5 NUDIX domain - - - 0.00000000000000000000000000000000000002605 154.0
TLS3_k127_3667366_6 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000927 128.0
TLS3_k127_3667366_7 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000006187 100.0
TLS3_k127_366907_0 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 573.0
TLS3_k127_366907_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 396.0
TLS3_k127_366907_2 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000002153 219.0
TLS3_k127_366907_3 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000003168 162.0
TLS3_k127_366907_4 Protein of unknown function DUF72 - - - 0.0000000000000000000000000001374 115.0
TLS3_k127_3669134_0 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000005187 260.0
TLS3_k127_3669134_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000066 250.0
TLS3_k127_3669134_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000001697 244.0
TLS3_k127_3681063_0 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 461.0
TLS3_k127_3681063_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 387.0
TLS3_k127_3681063_2 - - - - 0.0000000000000000000000000000000002677 144.0
TLS3_k127_3688947_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 4.093e-245 761.0
TLS3_k127_3688947_1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 467.0
TLS3_k127_3704435_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005487 496.0
TLS3_k127_3704435_1 Tfp pilus assembly protein, tip-associated adhesin PilY1 K02674 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 324.0
TLS3_k127_3704435_2 TIGRFAM prepilin-type N-terminal cleavage methylation domain K02655 - - 0.0000000000000000000006281 102.0
TLS3_k127_3704435_3 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000002144 85.0
TLS3_k127_3704435_4 Predicted membrane protein (DUF2061) - - - 0.000000000000008453 78.0
TLS3_k127_3709495_0 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway K00351 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 563.0
TLS3_k127_3709495_1 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00350 - 1.6.5.8 0.0000000000000000000000000000000000000000000000007536 176.0
TLS3_k127_3715530_0 Atp-dependent helicase K03578 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 460.0
TLS3_k127_3715530_1 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 415.0
TLS3_k127_3718783_0 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 492.0
TLS3_k127_3718783_1 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000001222 194.0
TLS3_k127_3741689_0 Periplasmic domain of Sensor histidine kinase RisS K07638 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 403.0
TLS3_k127_3741689_1 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000000000006532 210.0
TLS3_k127_3741689_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567,GO:0071704,GO:1901576 2.7.7.60 0.00000000000000000000000000000000000000000000000000000004687 205.0
TLS3_k127_3741689_3 response regulator K02483,K07659 - - 0.00000000000000000000000000000000000000000000000000009089 187.0
TLS3_k127_3741996_0 CoA-binding domain protein K09181 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 492.0
TLS3_k127_3789084_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 545.0
TLS3_k127_3789084_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 477.0
TLS3_k127_3789084_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000006772 234.0
TLS3_k127_3789084_3 Tetratricopeptide repeat K02656 - - 0.0000000000000000000000000000000000000000000000000000000000002477 220.0
TLS3_k127_3789084_4 Helix-turn-helix domain K15539 - - 0.000000000000000000000000008085 122.0
TLS3_k127_3799224_0 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 527.0
TLS3_k127_3799224_1 HDOD domain - - - 0.00000000000003106 85.0
TLS3_k127_3799882_0 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006169 266.0
TLS3_k127_3799882_1 Pfam:Pyridox_oxidase K07006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000211 256.0
TLS3_k127_3799882_2 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000000000000000000000000000007473 138.0
TLS3_k127_3810673_0 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 516.0
TLS3_k127_3810673_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 500.0
TLS3_k127_3810673_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 346.0
TLS3_k127_3810673_3 Acetyltransferase (GNAT) domain K03829 - - 0.00000000000000000000000000000000000000000000000000000000000000001315 227.0
TLS3_k127_3810673_4 GCN5-related N-acetyl-transferase K02346,K06975 - 2.7.7.7 0.00000000000000000000001626 104.0
TLS3_k127_3810673_5 Glycosyl transferase family 2 - - - 0.00000000000000001446 83.0
TLS3_k127_3817074_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 423.0
TLS3_k127_3817074_1 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000474 213.0
TLS3_k127_3817074_2 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000000003044 169.0
TLS3_k127_3818298_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 583.0
TLS3_k127_3818298_1 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000006617 236.0
TLS3_k127_3818298_2 binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000000000000000000000000003974 204.0
TLS3_k127_3818298_3 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000000000000000000000000000000000000003385 199.0
TLS3_k127_3818298_4 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000000000000000001651 151.0
TLS3_k127_3818298_5 Binds single-stranded DNA at the primosome assembly site (PAS) - - - 0.0000000000000006226 83.0
TLS3_k127_3823783_0 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009959 446.0
TLS3_k127_3823783_1 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 295.0
TLS3_k127_3823783_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002965 276.0
TLS3_k127_3845212_0 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 413.0
TLS3_k127_3845212_1 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 325.0
TLS3_k127_3845212_2 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000004057 237.0
TLS3_k127_3865642_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 575.0
TLS3_k127_3865642_1 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 435.0
TLS3_k127_3865642_2 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 362.0
TLS3_k127_3865771_0 Phenylacetic acid degradation protein PaaY K02617 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 294.0
TLS3_k127_3865771_1 phenylacetic acid degradation protein paaN - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003355 249.0
TLS3_k127_3865771_2 Protein of unknown function (DUF2783) - - - 0.000000000000000009543 84.0
TLS3_k127_3865771_3 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 0.00000000000001494 75.0
TLS3_k127_387903_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 442.0
TLS3_k127_387903_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006641 390.0
TLS3_k127_387903_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000171 156.0
TLS3_k127_387903_3 Domain of unknown function (DUF1850) - - - 0.000000000000000000000000000000001215 135.0
TLS3_k127_387903_4 Protein of unknown function (DUF2892) - - - 0.00000000000000000000001104 101.0
TLS3_k127_387903_5 Metal-sensitive transcriptional repressor - - - 0.00000000000000008165 85.0
TLS3_k127_3887615_0 Glycosyl hydrolase 36 superfamily, catalytic domain - - - 0.0 2712.0
TLS3_k127_3902483_0 Aldolase K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 406.0
TLS3_k127_3902483_1 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008384 267.0
TLS3_k127_3902483_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000006934 240.0
TLS3_k127_3902483_3 Protein of unknown function (DUF2799) - - - 0.00000000000000000000000000000002788 135.0
TLS3_k127_3935181_0 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 416.0
TLS3_k127_3935181_1 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000001917 201.0
TLS3_k127_395774_0 type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 489.0
TLS3_k127_395774_1 type II secretion system protein K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007218 336.0
TLS3_k127_395774_2 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009783 309.0
TLS3_k127_395774_3 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000002384 98.0
TLS3_k127_3969327_0 FAD linked oxidases, C-terminal domain K00102,K03777 - 1.1.2.4,1.1.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 514.0
TLS3_k127_3969327_1 Adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000003347 246.0
TLS3_k127_3970813_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 368.0
TLS3_k127_3970813_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007059 366.0
TLS3_k127_3970813_2 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000001172 254.0
TLS3_k127_3970813_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000005152 222.0
TLS3_k127_3970813_4 Putative member of DMT superfamily (DUF486) K09922 - - 0.000000000000000000000000000000000000000000000000000000000002312 210.0
TLS3_k127_3970813_5 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000000000001839 209.0
TLS3_k127_3970813_6 DoxX - - - 0.00000000000000000000000000000000000000000218 160.0
TLS3_k127_3970813_7 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053,K14160 - - 0.0000000000000000000000000000000000001809 159.0
TLS3_k127_3970813_8 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000003598 125.0
TLS3_k127_3970813_9 - - - - 0.000000000000000006742 84.0
TLS3_k127_3977551_0 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 552.0
TLS3_k127_3977551_1 very-long-chain-acyl-CoA dehydrogenase activity K17880,K18817 - 2.7.1.119,2.7.1.163 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 351.0
TLS3_k127_3977551_2 phosphatase activity - - - 0.00000000000000000000000000000000000000002972 156.0
TLS3_k127_4005323_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 588.0
TLS3_k127_4005323_1 Pfam:UPF0118 - - - 0.00000000000000000000002242 106.0
TLS3_k127_4008876_0 Lecithin:cholesterol acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 392.0
TLS3_k127_4008876_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 346.0
TLS3_k127_4008876_2 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.0000000000182 64.0
TLS3_k127_4011264_0 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 415.0
TLS3_k127_4011264_1 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000001978 201.0
TLS3_k127_412581_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1278.0
TLS3_k127_412581_1 Aminotransferase K14287 - 2.6.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 504.0
TLS3_k127_412581_10 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000001075 180.0
TLS3_k127_412581_11 transcriptional - - - 0.0000000000000000000000000000000000000000000002389 169.0
TLS3_k127_412581_12 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000000000000000000005656 166.0
TLS3_k127_412581_13 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.0000000000000000000000000000000000001045 157.0
TLS3_k127_412581_14 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000000007289 98.0
TLS3_k127_412581_15 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.00000002132 58.0
TLS3_k127_412581_2 PFAM peptidase M14, carboxypeptidase A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 456.0
TLS3_k127_412581_3 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007828 434.0
TLS3_k127_412581_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 368.0
TLS3_k127_412581_5 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 309.0
TLS3_k127_412581_6 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001786 279.0
TLS3_k127_412581_7 protein-L-isoaspartate O-methyltransferase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000001477 226.0
TLS3_k127_412581_8 peptidase K06194 - - 0.0000000000000000000000000000000000000000000000000000004504 208.0
TLS3_k127_412581_9 protein conserved in bacteria K09966 - - 0.000000000000000000000000000000000000000000000000001358 191.0
TLS3_k127_4135914_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 3.608e-204 644.0
TLS3_k127_4135914_1 Biopterin-dependent aromatic amino acid hydroxylase K00500 GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016714,GO:0055114 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000745 449.0
TLS3_k127_4135914_2 Tannase and feruloyl esterase - - - 0.00000000000000000000000000000000000000000000000000000000001819 226.0
TLS3_k127_4135914_3 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000007618 122.0
TLS3_k127_4142224_0 Sigma factor regulator FecR K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 372.0
TLS3_k127_4142224_1 UTRA K03710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 322.0
TLS3_k127_4142224_2 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000004299 173.0
TLS3_k127_4144258_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000131 175.0
TLS3_k127_4144258_1 - - - - 0.0000000000000000000000000000008044 126.0
TLS3_k127_4144258_2 Phosphopantetheine attachment site K02078 - - 0.000000000000000000001167 96.0
TLS3_k127_4144258_3 membrane - - - 0.00000000009759 68.0
TLS3_k127_4155187_0 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 387.0
TLS3_k127_4155187_1 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.00000000000000000000000000000000005736 139.0
TLS3_k127_4218364_0 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 460.0
TLS3_k127_4218364_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 450.0
TLS3_k127_4218364_2 Belongs to the ABC transporter superfamily K02031,K16202 - - 0.00000000014 72.0
TLS3_k127_423637_0 2-aminobenzoate-CoA ligase K08295 - 6.2.1.32 2.364e-219 696.0
TLS3_k127_423637_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 3.224e-217 686.0
TLS3_k127_423637_2 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 439.0
TLS3_k127_423637_3 depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001055 249.0
TLS3_k127_423637_4 Outer membrane protein (porin) K03285 - - 0.00000000000000000000000000000000000000000000000000008793 199.0
TLS3_k127_423637_5 nucleotidyltransferase activity - - - 0.000000000000000000000000006906 119.0
TLS3_k127_423637_6 Gram-negative porin - - - 0.000000000006809 69.0
TLS3_k127_423637_7 pathogenesis - - - 0.00004399 53.0
TLS3_k127_423637_8 - - - - 0.0009013 48.0
TLS3_k127_4303534_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 448.0
TLS3_k127_4303534_1 40-residue YVTN family beta-propeller repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 398.0
TLS3_k127_4303534_10 Phasin protein - - - 0.00000000000000000000000000000000000001143 152.0
TLS3_k127_4303534_2 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 399.0
TLS3_k127_4303534_3 Fatty acid hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 369.0
TLS3_k127_4303534_4 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004656 356.0
TLS3_k127_4303534_5 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 348.0
TLS3_k127_4303534_6 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 317.0
TLS3_k127_4303534_7 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 310.0
TLS3_k127_4303534_8 Drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008268 297.0
TLS3_k127_4303534_9 PFAM thioesterase superfamily protein K07107 - - 0.00000000000000000000000000000000000000000000000000003979 201.0
TLS3_k127_4307078_0 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 370.0
TLS3_k127_4307078_1 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 339.0
TLS3_k127_4307078_2 PFAM PsiF repeat protein - - - 0.0000000000000000004419 91.0
TLS3_k127_4307078_3 PFAM peptidase S16 lon domain protein K07157 - - 0.00000000000000007073 80.0
TLS3_k127_4307078_4 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000001105 72.0
TLS3_k127_4310080_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 7.249e-195 612.0
TLS3_k127_4310080_1 Heavy-metal-associated domain K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008539 496.0
TLS3_k127_4310080_2 TIGRFAM cytochrome oxidase maturation protein, cbb3-type - - - 0.000004406 51.0
TLS3_k127_4311740_0 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 1.362e-207 656.0
TLS3_k127_4311740_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 608.0
TLS3_k127_4311740_2 Bacterial protein of unknown function (Gcw_chp) - - - 0.0000000000000000000000000000000000000000000000000000000000000005925 228.0
TLS3_k127_4311740_3 Belongs to the P(II) protein family K04751,K04752 - - 0.00000000000000000000000000000000000000000000000000000000000544 211.0
TLS3_k127_4311740_4 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000002078 164.0
TLS3_k127_4311740_5 PRC-barrel domain - - - 0.000000000000000000000000000000004415 143.0
TLS3_k127_4311740_6 Membrane fusogenic activity K09806 - - 0.000000000000000001705 88.0
TLS3_k127_4311740_8 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00004219 56.0
TLS3_k127_4318013_0 Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA K00219,K09461 - 1.14.13.40,1.3.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 370.0
TLS3_k127_4318013_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005422 298.0
TLS3_k127_4318013_2 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000004202 174.0
TLS3_k127_4318013_3 PFAM LemA K03744 - - 0.00000000000000000000000006375 113.0
TLS3_k127_4321563_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 563.0
TLS3_k127_4321563_1 D-amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 466.0
TLS3_k127_4321563_2 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 330.0
TLS3_k127_4321563_3 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000006243 218.0
TLS3_k127_4321563_4 YaeQ - - - 0.00000000000000000000000000000000000000000000000000000000001214 211.0
TLS3_k127_4321563_5 membrane - - - 0.00000000000000000000000000000000000006105 145.0
TLS3_k127_432568_0 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 600.0
TLS3_k127_432568_1 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 386.0
TLS3_k127_432568_2 FAD dependent oxidoreductase K00244,K13796 - 1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 376.0
TLS3_k127_432568_3 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007761 339.0
TLS3_k127_432568_4 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 323.0
TLS3_k127_432568_5 Thioesterase superfamily protein K10806 - - 0.0000000000000000000000000000000000000000000000000000007549 200.0
TLS3_k127_432568_6 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000007364 180.0
TLS3_k127_4333633_0 TspO/MBR family K05770 - - 0.00000000000000000000000000000000000000000000000000000009152 199.0
TLS3_k127_4333633_1 PFAM Acetyltransferase (GNAT) family K00657 - 2.3.1.57 0.0000000000000000000000000000000000000000000000000002936 191.0
TLS3_k127_4333633_2 - - - - 0.0000000000000000000000000001033 126.0
TLS3_k127_4333633_3 - - - - 0.00000000000000000000000142 113.0
TLS3_k127_4351628_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 440.0
TLS3_k127_4351628_1 Belongs to the 'phage' integrase family - - - 0.0000000002039 64.0
TLS3_k127_4358577_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.136e-247 771.0
TLS3_k127_4358577_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 509.0
TLS3_k127_4358577_2 Ami_2 - - - 0.0009866 50.0
TLS3_k127_4358905_0 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006063 516.0
TLS3_k127_4358905_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 414.0
TLS3_k127_4358905_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 342.0
TLS3_k127_4369108_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 366.0
TLS3_k127_4369108_1 dihydroorotate dehydrogenase activity K00226 - 1.3.98.1 0.00000000000000000000000000000000000000000000000000001294 199.0
TLS3_k127_4374365_0 Belongs to the GcvT family K00315,K19191 - 1.5.3.19,1.5.8.4 0.0 1208.0
TLS3_k127_4374365_1 Aldehyde dehydrogenase family - - - 2.071e-199 635.0
TLS3_k127_4374365_2 Iron-containing alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 531.0
TLS3_k127_4374365_3 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 492.0
TLS3_k127_4374365_4 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 449.0
TLS3_k127_4374365_5 Peptidase C26 K01658,K07010 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 336.0
TLS3_k127_4374365_6 CHRD domain - - - 0.0000000000000000000000000000000000000000000000154 176.0
TLS3_k127_4375305_0 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 475.0
TLS3_k127_4375305_1 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020,K00042 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006573,GO:0006574,GO:0006807,GO:0008150,GO:0008152,GO:0008442,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 450.0
TLS3_k127_4375305_2 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000002306 222.0
TLS3_k127_4375305_3 Putative zinc-finger - - - 0.00000002468 57.0
TLS3_k127_4375305_4 Phosphoesterase - - - 0.00000007365 56.0
TLS3_k127_4378146_0 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006953 371.0
TLS3_k127_4378146_1 Belongs to the HpcH HpaI aldolase family K00979,K02510 - 2.7.7.38,4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001054 284.0
TLS3_k127_4378146_2 Domain of unknown function (DUF1932) K00020 - 1.1.1.31 0.0000000000000000000000000000000000000008464 160.0
TLS3_k127_4378146_3 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000006282 77.0
TLS3_k127_4383204_0 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 2.691e-239 759.0
TLS3_k127_4383204_1 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000000000008184 196.0
TLS3_k127_4383204_2 Enoyl-CoA hydratase carnithine racemase K13766,K15312 - 4.2.1.18 0.0000000000000000006789 88.0
TLS3_k127_4387650_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 7.896e-313 968.0
TLS3_k127_4387650_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000006489 53.0
TLS3_k127_4393163_0 peptidase M24 K01262 - 3.4.11.9 2.547e-265 829.0
TLS3_k127_4393163_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 458.0
TLS3_k127_4393163_2 heavy metal translocating P-type ATPase K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000003857 179.0
TLS3_k127_4393163_3 Phage late control gene D protein (GPD) K11904 - - 0.000000000000000000003672 100.0
TLS3_k127_4393163_4 - - - - 0.000000000000000005618 90.0
TLS3_k127_4396650_0 COG1840 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 401.0
TLS3_k127_4396650_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 400.0
TLS3_k127_4396650_2 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001162 276.0
TLS3_k127_4396650_3 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000726 110.0
TLS3_k127_4399972_0 ABC transporter K06020 - 3.6.3.25 2.504e-291 901.0
TLS3_k127_4399972_1 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 574.0
TLS3_k127_4399972_2 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 352.0
TLS3_k127_4399972_3 elongation factor G K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001256 252.0
TLS3_k127_4399972_4 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000001296 242.0
TLS3_k127_4399972_5 GCN5-related N-acetyl-transferase K06975 - - 0.0000000000000000000007049 110.0
TLS3_k127_4412479_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 1.346e-287 894.0
TLS3_k127_4412479_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 4.15e-217 679.0
TLS3_k127_4412479_10 nitrogen regulatory protein P-II - - - 0.000000000000000000000000000000005086 131.0
TLS3_k127_4412479_11 Fe-S assembly protein IscX - GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - 0.00000000000000000000000002534 109.0
TLS3_k127_4412479_2 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002796 244.0
TLS3_k127_4412479_3 permease K07086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006613 246.0
TLS3_k127_4412479_4 transcriptional regulator, Rrf2 family K13643 - - 0.0000000000000000000000000000000000000000000000000000000000000000008441 231.0
TLS3_k127_4412479_5 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000000000000000000002859 186.0
TLS3_k127_4412479_6 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000000000000000000002239 179.0
TLS3_k127_4412479_7 ferredoxin, 2Fe-2S type K04755 - - 0.000000000000000000000000000000000000000000000002545 174.0
TLS3_k127_4412479_8 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000000000311 168.0
TLS3_k127_4412479_9 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.000000000000000000000000000000000001196 139.0
TLS3_k127_4416295_0 PFAM heat shock protein DnaJ domain protein K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 370.0
TLS3_k127_4416295_1 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000001117 224.0
TLS3_k127_4416295_2 Belongs to the carbohydrate kinase PfkB family - - - 0.0000000000000000000000000000000000000000000000000000000006676 212.0
TLS3_k127_4421738_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 411.0
TLS3_k127_4421738_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009023 336.0
TLS3_k127_4421738_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002345 246.0
TLS3_k127_4421738_3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00001262 49.0
TLS3_k127_4432169_0 Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05559 - - 2.531e-313 986.0
TLS3_k127_4432169_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 473.0
TLS3_k127_4432169_10 Copper chaperone PCu(A)C K09796 - - 0.0000000000000000000000000000001511 134.0
TLS3_k127_4432169_11 PFAM multiple resistance and pH regulation protein F K05563 - - 0.000000000000000000000000105 108.0
TLS3_k127_4432169_12 heavy metal translocating P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000002121 61.0
TLS3_k127_4432169_2 Proton-conducting membrane transporter K00342,K05561,K05568 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 447.0
TLS3_k127_4432169_3 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 420.0
TLS3_k127_4432169_4 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 413.0
TLS3_k127_4432169_5 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004967 287.0
TLS3_k127_4432169_6 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000588 236.0
TLS3_k127_4432169_7 Na+/H+ ion antiporter subunit - - - 0.000000000000000000000000000000000000000005495 160.0
TLS3_k127_4432169_8 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05560 - - 0.0000000000000000000000000000000000001126 149.0
TLS3_k127_4432169_9 COG1320 Multisubunit Na H antiporter, MnhG subunit K05564 - - 0.00000000000000000000000000000004457 132.0
TLS3_k127_4446801_0 Carbon-nitrogen hydrolase K01501 - 3.5.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 394.0
TLS3_k127_4446801_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K15942 - 2.1.1.288 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 368.0
TLS3_k127_4446801_2 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 314.0
TLS3_k127_4446801_3 RIO1 family K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000005789 228.0
TLS3_k127_4446947_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 409.0
TLS3_k127_4446947_1 AMP-binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005368 377.0
TLS3_k127_4450618_0 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 364.0
TLS3_k127_4450618_1 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000001682 226.0
TLS3_k127_4450618_2 - - - - 0.0000000000000000000000002655 115.0
TLS3_k127_4450618_3 - - - - 0.00000000000008635 71.0
TLS3_k127_4453525_0 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.0000000000000001144 79.0
TLS3_k127_4453525_1 helix_turn_helix, Lux Regulon - - - 0.0001807 53.0
TLS3_k127_4477226_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 512.0
TLS3_k127_4477226_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000004872 183.0
TLS3_k127_4486160_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 425.0
TLS3_k127_4499692_0 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005711 578.0
TLS3_k127_4499692_1 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000008879 179.0
TLS3_k127_4508200_0 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 492.0
TLS3_k127_4508200_1 Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 355.0
TLS3_k127_4508200_2 Domain of unknown function (DUF3473) - - - 0.0000000000000000000000000000000000000000009384 169.0
TLS3_k127_4508200_3 TIGRFAM PEP-CTERM system associated protein - - - 0.000000000000000000000000003023 123.0
TLS3_k127_4513811_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 2.97e-204 652.0
TLS3_k127_4513811_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000005965 209.0
TLS3_k127_4526545_0 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 371.0
TLS3_k127_4526545_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000819 334.0
TLS3_k127_4526545_2 dehydratase - - - 0.000002205 50.0
TLS3_k127_4546915_0 PFAM TadE family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 312.0
TLS3_k127_4546915_1 COG3745 Flp pilus assembly protein CpaB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003161 280.0
TLS3_k127_4546915_2 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001763 273.0
TLS3_k127_4546915_3 Belongs to the GSP D family - - - 0.0000000000000000000000000000000000000000000000000005534 195.0
TLS3_k127_4546915_4 - - - - 0.0000000000000000000000000000000000000003573 161.0
TLS3_k127_4546915_5 - - - - 0.00000000000000000000000006704 110.0
TLS3_k127_4570869_0 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 395.0
TLS3_k127_4570869_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000008289 181.0
TLS3_k127_4573195_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1549.0
TLS3_k127_4573195_1 Nitric oxide reductase large subunit K04561 - 1.7.2.5 0.0 1272.0
TLS3_k127_4573195_10 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 558.0
TLS3_k127_4573195_11 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 529.0
TLS3_k127_4573195_12 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 535.0
TLS3_k127_4573195_13 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 420.0
TLS3_k127_4573195_14 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 407.0
TLS3_k127_4573195_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005514 383.0
TLS3_k127_4573195_16 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001023 276.0
TLS3_k127_4573195_17 Universal stress protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000186 237.0
TLS3_k127_4573195_18 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000004357 182.0
TLS3_k127_4573195_19 Uncharacterized protein conserved in bacteria (DUF2219) - - - 0.0000000000000000000000000000000000000000000006201 185.0
TLS3_k127_4573195_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0 1034.0
TLS3_k127_4573195_20 Invasion gene expression up-regulator, SirB - - - 0.000000000000000000000000000000000000002552 151.0
TLS3_k127_4573195_21 response regulator, receiver - - - 0.00000000000000000000000000000000000002195 149.0
TLS3_k127_4573195_22 - - - - 0.0000000000000000000000000000000001271 139.0
TLS3_k127_4573195_23 Transcriptional regulator K18301 - - 0.00000000000000000002415 100.0
TLS3_k127_4573195_24 - - - - 0.000000000000000001008 87.0
TLS3_k127_4573195_26 - - - - 0.00000000000005757 77.0
TLS3_k127_4573195_27 MgtC family K07507 - - 0.00000000009722 66.0
TLS3_k127_4573195_3 AAA ATPase domain - - - 0.0 1032.0
TLS3_k127_4573195_4 Multicopper oxidase K00368 - 1.7.2.1 2.523e-278 863.0
TLS3_k127_4573195_5 Ubiquinone biosynthesis protein K03688 - - 5.327e-247 774.0
TLS3_k127_4573195_6 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 5.515e-233 728.0
TLS3_k127_4573195_7 protein involved in response to NO K07234 - - 2.322e-203 640.0
TLS3_k127_4573195_8 Peptidase dimerisation domain - - - 2.026e-201 638.0
TLS3_k127_4573195_9 cysteine synthase K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 586.0
TLS3_k127_457374_0 OsmC-like protein K06889,K07397 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 444.0
TLS3_k127_457374_1 KR domain K00059,K00076 - 1.1.1.100,1.1.1.159 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005058 359.0
TLS3_k127_457374_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000965 86.0
TLS3_k127_4581609_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 2.334e-219 688.0
TLS3_k127_4581609_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000003558 237.0
TLS3_k127_4581609_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000009629 233.0
TLS3_k127_460957_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 3.44e-240 749.0
TLS3_k127_460957_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 5.203e-198 621.0
TLS3_k127_460957_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 385.0
TLS3_k127_460957_3 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 306.0
TLS3_k127_460957_4 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000298 253.0
TLS3_k127_460957_5 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000002823 226.0
TLS3_k127_460957_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000009605 220.0
TLS3_k127_460957_7 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000005815 137.0
TLS3_k127_460957_8 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000006288 111.0
TLS3_k127_4617728_0 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 0.0 1548.0
TLS3_k127_4617728_1 Alpha-amylase domain K01187 - 3.2.1.20 0.0 1487.0
TLS3_k127_4617728_2 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1111.0
TLS3_k127_4617728_3 trehalohydrolase K01236 - 3.2.1.141 9.716e-225 719.0
TLS3_k127_4617728_4 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 531.0
TLS3_k127_4617728_5 PFAM Conserved TM helix repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002683 255.0
TLS3_k127_4617728_6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 0.00000000000000000000000000000000000000004035 154.0
TLS3_k127_4655749_0 PFAM 6-phosphogluconate dehydrogenase NAD-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 389.0
TLS3_k127_4655749_1 Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 359.0
TLS3_k127_4655749_2 5-dehydro-2-deoxygluconokinase K03338 - 2.7.1.92 0.000000000000000000000000000004234 124.0
TLS3_k127_4658408_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1981.0
TLS3_k127_4664340_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009485 384.0
TLS3_k127_4664340_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003917 351.0
TLS3_k127_4664340_2 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000001838 209.0
TLS3_k127_4664340_3 chemotaxis K00575 - 2.1.1.80 0.00001349 47.0
TLS3_k127_4677876_0 Circadian K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000747 550.0
TLS3_k127_4677876_1 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000000000000000000000000000008688 206.0
TLS3_k127_4677876_2 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000007239 135.0
TLS3_k127_4687102_0 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 9.02e-255 796.0
TLS3_k127_4687102_1 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000001044 135.0
TLS3_k127_4687102_2 KTSC domain - - - 0.000000000000000000000000000003892 124.0
TLS3_k127_4700683_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005502 617.0
TLS3_k127_4700683_1 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 495.0
TLS3_k127_4746128_0 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.0 1260.0
TLS3_k127_4746128_1 PFAM aminotransferase, class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 592.0
TLS3_k127_4746128_2 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 370.0
TLS3_k127_4746128_3 COG1178 ABC-type Fe3 transport system, permease component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005257 259.0
TLS3_k127_4746128_4 spore germination - - - 0.000000000000000000000000000000000000000000000000000000000000004452 227.0
TLS3_k127_4746128_5 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000003972 112.0
TLS3_k127_4778982_0 Phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 548.0
TLS3_k127_4778982_1 Cys/Met metabolism PLP-dependent enzyme K01760 - 4.4.1.8 0.00004461 47.0
TLS3_k127_4781821_0 Belongs to the GMC oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005357 418.0
TLS3_k127_4781821_1 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004357 277.0
TLS3_k127_4856499_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K09461 - 1.14.13.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 539.0
TLS3_k127_4867468_0 Protein of unknown function - - - 3.435e-248 814.0
TLS3_k127_4867468_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 1.852e-214 674.0
TLS3_k127_4867468_2 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 361.0
TLS3_k127_4889012_0 Aldo keto K00011 - 1.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 286.0
TLS3_k127_4889012_1 PepSY-associated TM region - - - 0.000000000000000000000000000000000000000000001993 179.0
TLS3_k127_4889012_2 Protein of unknown function (DUF3072) - - - 0.000000000000000000000000009627 112.0
TLS3_k127_4900397_0 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006102 441.0
TLS3_k127_4900397_1 ABC transporter K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000008432 265.0
TLS3_k127_4916051_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 380.0
TLS3_k127_4916051_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.000000000000000000000000000000000000002824 149.0
TLS3_k127_4935778_0 DNA helicase K03654 - 3.6.4.12 3.424e-277 859.0
TLS3_k127_4935778_1 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 337.0
TLS3_k127_4935778_2 Pentapeptide repeats (9 copies) - - - 0.00000000000000000000000003726 112.0
TLS3_k127_4935778_3 - - - - 0.00000000000000000000003934 107.0
TLS3_k127_4935778_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000003605 98.0
TLS3_k127_4935778_5 Protein of unknown function (DUF3788) - - - 0.0000000000000004766 84.0
TLS3_k127_4935778_6 ISXO2-like transposase domain K07488 - - 0.0000000001602 61.0
TLS3_k127_4956447_0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 298.0
TLS3_k127_4956447_1 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 300.0
TLS3_k127_4956447_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000001635 92.0
TLS3_k127_4972454_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 7.225e-210 664.0
TLS3_k127_4972454_1 Sodium:solute symporter family K14392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 613.0
TLS3_k127_4972454_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007862 369.0
TLS3_k127_4972454_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 372.0
TLS3_k127_4972454_4 import inner membrane translocase, subunit Tim44 - - - 0.0000000000000000000000000000000000000000000000000006759 196.0
TLS3_k127_4972454_5 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000001681 173.0
TLS3_k127_4972454_6 - - - - 0.000000000000000000000000000000000000000003895 167.0
TLS3_k127_4972454_7 SCP-2 sterol transfer family K03690 - - 0.00000000000000000000000000000002863 133.0
TLS3_k127_4980904_0 Calx-beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 302.0
TLS3_k127_4980904_1 Tetratricopeptide repeat - - - 0.0000000002415 73.0
TLS3_k127_500514_0 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 428.0
TLS3_k127_500514_1 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 371.0
TLS3_k127_500514_2 Dehydrogenase K00043 - 1.1.1.61 0.0000000000000000756 82.0
TLS3_k127_500514_3 Extracellular ligand-binding receptor K01999 - - 0.0000168 47.0
TLS3_k127_506201_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004719 421.0
TLS3_k127_506201_1 fumarylacetoacetate (FAA) hydrolase K16165 - 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000001727 227.0
TLS3_k127_5078070_0 Transglycosylase SLT domain K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 422.0
TLS3_k127_5078070_1 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 316.0
TLS3_k127_5139469_0 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 435.0
TLS3_k127_5139469_1 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000001192 224.0
TLS3_k127_5139469_2 Flagellar regulatory protein FleQ - - - 0.0000000000000000000000000000785 120.0
TLS3_k127_5139469_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000002328 87.0
TLS3_k127_5164764_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008856 397.0
TLS3_k127_5164764_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 305.0
TLS3_k127_5164764_2 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000008087 210.0
TLS3_k127_5164764_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000001258 117.0
TLS3_k127_5167350_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 5.334e-205 643.0
TLS3_k127_5167350_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 440.0
TLS3_k127_5167350_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000002657 213.0
TLS3_k127_5167350_11 rieske 2fe-2s - - - 0.000000000000000000000000000000000001003 142.0
TLS3_k127_5167350_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000005926 138.0
TLS3_k127_5167350_13 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000000009247 131.0
TLS3_k127_5167350_14 Ribosomal L32p protein family K02911 - - 0.000000000000000000000000002573 112.0
TLS3_k127_5167350_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 430.0
TLS3_k127_5167350_3 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 397.0
TLS3_k127_5167350_4 malonyl CoA-acyl carrier protein transacylase K00645,K15355 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 381.0
TLS3_k127_5167350_5 reductase K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 342.0
TLS3_k127_5167350_6 HAD hydrolase, family IA, variant K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000003726 246.0
TLS3_k127_5167350_7 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000001548 229.0
TLS3_k127_5167350_8 Uroporphyrin-iii c tetrapyrrole (Corrin porphyrin) methyltransferase K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000003342 241.0
TLS3_k127_5167350_9 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000001341 220.0
TLS3_k127_5173371_0 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 619.0
TLS3_k127_5173371_1 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 609.0
TLS3_k127_5173371_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000006011 174.0
TLS3_k127_5173371_11 Uroporphyrinogen III synthase HEM4 K02496,K13543 - 2.1.1.107,4.2.1.75 0.00000000000000000000001077 110.0
TLS3_k127_5173371_2 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 473.0
TLS3_k127_5173371_3 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 437.0
TLS3_k127_5173371_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 371.0
TLS3_k127_5173371_5 LytTr DNA-binding domain K08083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004382 269.0
TLS3_k127_5173371_6 Tripartite ATP-independent periplasmic transporter DctQ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004135 242.0
TLS3_k127_5173371_7 HemY protein N-terminus K02498 - - 0.00000000000000000000000000000000000000000000000000000000000000000001899 248.0
TLS3_k127_5173371_8 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000002716 227.0
TLS3_k127_5173371_9 HemX, putative uroporphyrinogen-III C-methyltransferase K02496,K13543 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000005461 189.0
TLS3_k127_5174818_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 2.754e-264 821.0
TLS3_k127_5174818_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.358e-208 653.0
TLS3_k127_5174818_2 ABC-type branched-chain amino acid transport K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 500.0
TLS3_k127_5174818_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 381.0
TLS3_k127_5174818_4 membrane-bound metal-dependent K07038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 368.0
TLS3_k127_5174818_5 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 355.0
TLS3_k127_5174818_6 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 306.0
TLS3_k127_5174818_7 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000000000000005109 147.0
TLS3_k127_5174818_8 Protein of unknown function (DUF541) - - - 0.00000000000000000000000000000033 132.0
TLS3_k127_5176091_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1420.0
TLS3_k127_5176091_1 - - - - 0.000000000000000000000000000000000000003092 162.0
TLS3_k127_5177472_0 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 492.0
TLS3_k127_5177472_1 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 398.0
TLS3_k127_5177472_2 amidohydrolase K01451 - 3.5.1.32 0.000000000000000000000000000000000000000000000003427 173.0
TLS3_k127_5177472_3 Universal stress protein - - - 0.00000000000000000002356 100.0
TLS3_k127_5177472_4 - - - - 0.000000000000000009399 90.0
TLS3_k127_5177472_5 - - - - 0.0000000479 60.0
TLS3_k127_5184322_0 O-Methyltransferase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002155 271.0
TLS3_k127_5184322_1 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000007943 255.0
TLS3_k127_5184322_2 rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000003183 160.0
TLS3_k127_5184322_3 TIGRFAM type I secretion outer membrane protein, TolC family K12340 - - 0.00000000000000000004384 100.0
TLS3_k127_5185771_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 427.0
TLS3_k127_5185771_1 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 317.0
TLS3_k127_5185771_2 GTP-binding protein K06207 - - 0.0000000000000000000000000000000000000003687 149.0
TLS3_k127_5185771_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000006704 151.0
TLS3_k127_5192300_0 Quinone oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 385.0
TLS3_k127_5192300_1 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000000000000000000000000000000000000000000000000002255 212.0
TLS3_k127_5192300_2 ATPases involved in chromosome partitioning K03496 - - 0.0000957 46.0
TLS3_k127_5197393_0 TIGRFAM maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 300.0
TLS3_k127_5197393_1 Lytic murein transglycosylase B K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002697 274.0
TLS3_k127_5197393_2 DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000001896 220.0
TLS3_k127_5197393_3 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000009861 215.0
TLS3_k127_5211075_0 Aminotransferase class-III K00819 - 2.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 520.0
TLS3_k127_5211075_1 Amidinotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002115 301.0
TLS3_k127_5211075_2 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000000000000000000003084 173.0
TLS3_k127_5218210_0 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002394 258.0
TLS3_k127_5218210_1 COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding) K01849,K20907 - 5.4.99.2,5.4.99.64 0.000000000000000000000000000000000000000001535 157.0
TLS3_k127_5218210_3 MaoC like domain K17865 GO:0003674,GO:0003824,GO:0003859,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0071704 4.2.1.55 0.0000004293 59.0
TLS3_k127_5218478_0 Sigma-54 interaction domain K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 4.158e-219 690.0
TLS3_k127_5218478_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 299.0
TLS3_k127_5218478_2 Histidine kinase K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001486 264.0
TLS3_k127_5218478_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007278 252.0
TLS3_k127_5219775_0 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 454.0
TLS3_k127_5219775_1 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009672 302.0
TLS3_k127_5219775_2 Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008048 281.0
TLS3_k127_5219775_3 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000000000000000001225 178.0
TLS3_k127_5238395_0 ABC transporter K15738 - - 4.119e-195 626.0
TLS3_k127_5238395_1 nitric oxide reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 288.0
TLS3_k127_5238395_2 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005251 268.0
TLS3_k127_5238395_3 COG1309 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000002057 218.0
TLS3_k127_5238395_4 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000001572 181.0
TLS3_k127_5238395_5 PFAM Thioredoxin K00384 - 1.8.1.9 0.000000000000000000000003004 108.0
TLS3_k127_5238395_6 Alpha/beta hydrolase family - - - 0.000000000000000003163 86.0
TLS3_k127_5238395_7 Glycine zipper - - - 0.0000000003836 65.0
TLS3_k127_5242276_0 Belongs to the ClpA ClpB family K03694 - - 2.059e-301 934.0
TLS3_k127_5242276_1 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 1.181e-234 729.0
TLS3_k127_5242276_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000007066 158.0
TLS3_k127_5242276_3 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000000000001765 138.0
TLS3_k127_5263425_0 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001046 249.0
TLS3_k127_5263425_1 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000455 235.0
TLS3_k127_5263425_2 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000001682 214.0
TLS3_k127_5263425_3 redox protein regulator of disulfide bond formation K07397 - - 0.000000000000000000000000000000000000000000000000000005815 193.0
TLS3_k127_5263425_4 - - - - 0.00000000000000000000000000000000000000000000000000001187 200.0
TLS3_k127_5263425_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000235 122.0
TLS3_k127_5267826_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 5.485e-213 668.0
TLS3_k127_5267826_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006999 275.0
TLS3_k127_5269254_0 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 5.751e-245 759.0
TLS3_k127_5269254_1 Glycosyl hydrolase 36 superfamily, catalytic domain - - - 5.377e-219 699.0
TLS3_k127_5269254_2 Aminotransferase class-III K00823 - 2.6.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008693 593.0
TLS3_k127_5269254_3 amidohydrolase K01451 - 3.5.1.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 569.0
TLS3_k127_5269254_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 429.0
TLS3_k127_5269254_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 416.0
TLS3_k127_5299813_0 carboxylase K01969 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 507.0
TLS3_k127_5299813_1 Sugar (and other) transporter K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 456.0
TLS3_k127_5301663_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008995 594.0
TLS3_k127_5301663_1 THUMP domain K07444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 401.0
TLS3_k127_5301663_2 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000149 218.0
TLS3_k127_5301663_3 PFAM conserved K08973 - - 0.0000000000000000000000000000000000000000000003279 171.0
TLS3_k127_5301663_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000001969 160.0
TLS3_k127_5301663_5 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000863 143.0
TLS3_k127_5301663_6 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000003151 115.0
TLS3_k127_5301663_7 heat shock protein binding - - - 0.000000000000001895 78.0
TLS3_k127_5307519_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.091e-245 762.0
TLS3_k127_5307519_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 387.0
TLS3_k127_5307519_2 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000008947 183.0
TLS3_k127_5307519_3 there appears to be two types of ribosomal proteins L31 in bacterial genomes K02909 - - 0.00000000000000000000000000000004325 130.0
TLS3_k127_5343039_0 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000001022 194.0
TLS3_k127_5343039_1 TIR domain - - - 0.0000000000000000000000000000000000000000009041 169.0
TLS3_k127_5343039_2 PASTA K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000006806 88.0
TLS3_k127_5343039_3 aldo keto reductase K19265 - - 0.00000000000003474 73.0
TLS3_k127_5343039_4 serine-type endopeptidase activity - - - 0.0000000003437 71.0
TLS3_k127_5351513_0 Uncharacterized protein conserved in bacteria (DUF2090) K03338 - 2.7.1.92 2.411e-206 666.0
TLS3_k127_5351513_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 427.0
TLS3_k127_5351513_2 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 326.0
TLS3_k127_5351513_3 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 304.0
TLS3_k127_5351513_4 PFAM 6-phosphogluconate dehydrogenase NAD-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002135 275.0
TLS3_k127_5351513_5 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000006991 239.0
TLS3_k127_5351513_6 Sugar isomerase (SIS) - - - 0.00000000000000000000000000000000000000000000000000000000000001158 232.0
TLS3_k127_5351513_7 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.0008381 44.0
TLS3_k127_5371139_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000247 292.0
TLS3_k127_5371139_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006211 251.0
TLS3_k127_5371139_2 Acyl-CoA dehydrogenase, middle domain K00252 - 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000002196 214.0
TLS3_k127_5371139_3 acetylesterase activity - - - 0.00000000000000000000000000000000000000000000000006474 180.0
TLS3_k127_5384122_0 Cyclohexanecarboxylate-CoA ligase K04116,K12507 - - 1.228e-225 710.0
TLS3_k127_5384122_1 4-hydroxyphenylacetate K00483,K14534 - 1.14.14.9,4.2.1.120,5.3.3.3 4e-218 688.0
TLS3_k127_5384122_10 Forkhead associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002256 236.0
TLS3_k127_5384122_11 Hemerythrin - - - 0.000000000000000000000000000000000000000000000001815 179.0
TLS3_k127_5384122_12 COG1335 Amidases related to nicotinamidase - - - 0.0000000000000000000000000000000000000000000004076 175.0
TLS3_k127_5384122_13 Short-chain dehydrogenase reductase (SDR) K00059 - 1.1.1.100 0.00000000000000000000000002086 109.0
TLS3_k127_5384122_14 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000003039 109.0
TLS3_k127_5384122_15 MazG-like family - - - 0.00000000000000000000001019 110.0
TLS3_k127_5384122_16 Cytochrome c K17223 - - 0.000000000000000000005461 109.0
TLS3_k127_5384122_2 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 5.25e-199 632.0
TLS3_k127_5384122_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 538.0
TLS3_k127_5384122_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 503.0
TLS3_k127_5384122_5 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 454.0
TLS3_k127_5384122_6 Saccharopine dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005564 428.0
TLS3_k127_5384122_7 Trypsin-like peptidase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004704 424.0
TLS3_k127_5384122_8 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 310.0
TLS3_k127_5384122_9 Type ii and iii secretion system protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006197 274.0
TLS3_k127_5398468_0 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.0000000000000000000000000000000000000000000007088 184.0
TLS3_k127_5400625_0 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 411.0
TLS3_k127_5400625_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000247 275.0
TLS3_k127_5400625_2 Belongs to the Dps family - - - 0.000000000000000000000000000000000000000000000000000000000000000001865 236.0
TLS3_k127_5447391_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 2.914e-217 689.0
TLS3_k127_5447391_1 Acyl-CoA dehydrogenase, C-terminal domain K19966 - 3.13.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 566.0
TLS3_k127_5447391_2 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 565.0
TLS3_k127_5447391_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009964 409.0
TLS3_k127_5447391_4 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.00000000000000000000000000000000000001187 150.0
TLS3_k127_5447391_5 CoA-transferase family III - - - 0.0000000000000000000000000000000009817 132.0
TLS3_k127_5507453_0 AcrB/AcrD/AcrF family K03296,K18138,K18902 - - 3.273e-298 925.0
TLS3_k127_5507453_1 AAA ATPase domain - - - 4.601e-293 924.0
TLS3_k127_5507453_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 405.0
TLS3_k127_5507453_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006976 378.0
TLS3_k127_5507453_4 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001022 242.0
TLS3_k127_5507453_5 Peptidase M15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000008386 235.0
TLS3_k127_5507453_6 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000000000018 143.0
TLS3_k127_5519769_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 334.0
TLS3_k127_5519769_1 PFAM regulatory protein TetR K03577 - - 0.000000000000000000000000000000000000000000000000007569 186.0
TLS3_k127_5519769_2 Efflux pump membrane transporter K03296,K18138 - - 0.000007018 51.0
TLS3_k127_5540197_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 484.0
TLS3_k127_5540197_1 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005002 355.0
TLS3_k127_5540197_10 Integral membrane protein (DUF2244) - - - 0.00000000000000000000000000344 117.0
TLS3_k127_5540197_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 345.0
TLS3_k127_5540197_3 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000514 248.0
TLS3_k127_5540197_4 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000000000005772 224.0
TLS3_k127_5540197_5 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000007971 207.0
TLS3_k127_5540197_6 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.0000000000000000000000000000000000000000000000000000002417 199.0
TLS3_k127_5540197_7 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000000002568 166.0
TLS3_k127_5540197_8 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000001327 141.0
TLS3_k127_5540197_9 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000000000000005277 134.0
TLS3_k127_5594188_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.036e-265 824.0
TLS3_k127_5594188_1 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007894 504.0
TLS3_k127_5594188_2 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 323.0
TLS3_k127_5594188_3 Phosphoglycolate phosphatase K22292 - 3.1.3.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004044 280.0
TLS3_k127_5594188_4 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000000000000000000000000000000001407 222.0
TLS3_k127_5594188_5 Belongs to the DEAD box helicase family K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.000000000000000000000000000001973 125.0
TLS3_k127_5607809_0 phenylacetic acid degradation protein paaN - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 516.0
TLS3_k127_5607809_1 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 338.0
TLS3_k127_5616037_0 Integrase core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 415.0
TLS3_k127_5616037_1 Transposase - - - 0.000000000000000000000000000000000000003285 147.0
TLS3_k127_5616037_2 Domain of unknown function (DUF892) - - - 0.00000004449 59.0
TLS3_k127_5619115_0 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000001178 142.0
TLS3_k127_5619115_1 Prolyl oligopeptidase family - - - 0.00000000000000000000000000004345 116.0
TLS3_k127_5626865_0 Putative transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 507.0
TLS3_k127_5626865_1 phage integrase domain protein SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 346.0
TLS3_k127_5626865_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000001266 201.0
TLS3_k127_5674179_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 563.0
TLS3_k127_5674179_1 succinate dehydrogenase, hydrophobic membrane anchor protein K00242 - - 0.00000000000000000000000000000000004197 141.0
TLS3_k127_5674179_2 Succinate dehydrogenase cytochrome b556 subunit K00241 - - 0.0000000000000000000000000000009402 126.0
TLS3_k127_5680581_0 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 550.0
TLS3_k127_5680581_1 ABC-type phosphate phosphonate transport system periplasmic component K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 486.0
TLS3_k127_5680581_10 Belongs to the BolA IbaG family K05527 - - 0.00000000000000000000000009614 109.0
TLS3_k127_5680581_11 Dodecin K09165 - - 0.00000000000000000001176 94.0
TLS3_k127_5680581_12 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000001282 91.0
TLS3_k127_5680581_2 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007864 419.0
TLS3_k127_5680581_3 Belongs to the carbohydrate kinase PfkB family K00882,K00917,K16370 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 2.7.1.11,2.7.1.144,2.7.1.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 346.0
TLS3_k127_5680581_4 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 303.0
TLS3_k127_5680581_5 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000001398 244.0
TLS3_k127_5680581_6 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003723 244.0
TLS3_k127_5680581_7 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000007772 182.0
TLS3_k127_5680581_8 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - - 0.000000000000000000000000000000000000000000000001294 179.0
TLS3_k127_5680581_9 Pilin (bacterial filament) K02650 - - 0.00000000000000000000000000000000000000000005194 166.0
TLS3_k127_5683976_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 559.0
TLS3_k127_5683976_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005111 525.0
TLS3_k127_5683976_2 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 455.0
TLS3_k127_5683976_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 445.0
TLS3_k127_5683976_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 320.0
TLS3_k127_5683976_5 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 297.0
TLS3_k127_5683976_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000006249 240.0
TLS3_k127_5683976_7 cellulase activity - - - 0.0000000000000000000000001677 123.0
TLS3_k127_5683976_8 sister chromatid segregation - - - 0.0000000000002614 74.0
TLS3_k127_5722699_0 ABC-type branched-chain amino acid transport systems periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 507.0
TLS3_k127_5722699_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 377.0
TLS3_k127_5722699_2 Histidine kinase K20975 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 340.0
TLS3_k127_5722699_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006215 331.0
TLS3_k127_5722699_4 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000002315 199.0
TLS3_k127_5722699_5 - - - - 0.0000000000000000000000000000000000000000003923 169.0
TLS3_k127_5722699_6 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000162 143.0
TLS3_k127_5722699_7 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000004636 131.0
TLS3_k127_5722699_8 Transcriptional Regulator, AraC family - - - 0.00000000000000077 80.0
TLS3_k127_5734108_0 integrase core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000009475 244.0
TLS3_k127_5734108_1 IstB-like ATP binding protein - - - 0.0000000000000000000000000000001434 132.0
TLS3_k127_5734108_2 - - - - 0.00000000002064 70.0
TLS3_k127_575576_0 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 3.084e-205 642.0
TLS3_k127_575576_1 dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000504 369.0
TLS3_k127_575576_2 transposase K07491 - - 0.0000000000000000000000000000000000000000000000000000000001591 211.0
TLS3_k127_5834437_0 type II secretion system protein E K02454,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 535.0
TLS3_k127_5874534_0 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 380.0
TLS3_k127_5874534_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 321.0
TLS3_k127_5874534_2 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000000001591 110.0
TLS3_k127_5874534_3 - - - - 0.0000000000000000000000004086 107.0
TLS3_k127_5908019_0 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 438.0
TLS3_k127_5908019_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004728 385.0
TLS3_k127_5908019_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 315.0
TLS3_k127_5908019_3 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 291.0
TLS3_k127_5908019_4 Anabaena sensory rhodopsin transducer - - - 0.00000000000000000000000000000000000000000000000000000000003781 209.0
TLS3_k127_5908019_5 COG4635 Flavodoxin K00230 - 1.3.5.3 0.000000000000000000000000000000000000006752 156.0
TLS3_k127_5908019_6 CoA binding domain K09181 - - 0.000000000000000000000000001637 122.0
TLS3_k127_6025286_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 449.0
TLS3_k127_6025286_1 Isocitrate lyase K01637 - 4.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 418.0
TLS3_k127_6025286_2 Belongs to the 5'-nucleotidase family K01081,K11751 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006213,GO:0006259,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007155,GO:0007159,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009164,GO:0009166,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019362,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0022610,GO:0031974,GO:0031981,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046135,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0072524,GO:0072527,GO:0072529,GO:0090304,GO:0098609,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 423.0
TLS3_k127_6025286_3 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 - - 0.000000000000000000000000000000000000000000000000004816 195.0
TLS3_k127_6025302_0 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 1.297e-223 700.0
TLS3_k127_6025302_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 350.0
TLS3_k127_6025302_2 Thioesterase-like superfamily K07107 - - 0.0000000000000000006866 90.0
TLS3_k127_6025315_0 RNB K01147 - 3.1.13.1 6.165e-216 693.0
TLS3_k127_6025315_1 COG0810 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.00000000000000000000000000000000000000000000000000000000000002128 225.0
TLS3_k127_6025315_2 Aminoacyl-tRNA editing domain - - - 0.0000000000000000000000000000000000000002834 155.0
TLS3_k127_6025315_3 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000004212 68.0
TLS3_k127_6037930_0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 542.0
TLS3_k127_6046711_0 amp-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 417.0
TLS3_k127_6046711_1 single-stranded DNA 5'-3' exodeoxyribonuclease activity - - - 0.00000000000001221 76.0
TLS3_k127_6048293_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.642e-230 727.0
TLS3_k127_6048293_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 312.0
TLS3_k127_6048293_2 PFAM L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000002701 229.0
TLS3_k127_6048293_3 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000000000000009216 200.0
TLS3_k127_6048293_4 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000178 188.0
TLS3_k127_6048293_5 Pfam Periplasmic binding protein - - - 0.00000000000000000000000000000000000000000006293 162.0
TLS3_k127_6048293_6 Sporulation related domain - - - 0.00000000000000000000000000000000004459 143.0
TLS3_k127_6051849_0 Type II/IV secretion system protein K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 460.0
TLS3_k127_6051849_1 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 407.0
TLS3_k127_6051849_2 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 302.0
TLS3_k127_6051849_3 COG0436 Aspartate tyrosine aromatic aminotransferase K14261,K14267 - 2.6.1.17 0.00000000003128 64.0
TLS3_k127_6056833_0 5'-nucleotidase, C-terminal domain K11751,K17224 - 3.1.3.5,3.6.1.45 6.122e-294 916.0
TLS3_k127_6056833_1 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 351.0
TLS3_k127_6056833_2 Cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000000000000000000000001757 229.0
TLS3_k127_6056833_3 Sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000000000000000000000000006435 201.0
TLS3_k127_6056833_4 Sulphur oxidation protein SoxZ K17227 - - 0.000000000000000000000000000000000000000203 151.0
TLS3_k127_6056833_5 Thioredoxin-like - - - 0.0000000000000000000000000000000000792 139.0
TLS3_k127_6056833_6 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000001777 101.0
TLS3_k127_6057110_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1294.0
TLS3_k127_6057110_1 E1-E2 ATPase K17686 - 3.6.3.54 0.0 1014.0
TLS3_k127_6057110_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 517.0
TLS3_k127_6057110_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 441.0
TLS3_k127_6057110_4 PFAM Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 317.0
TLS3_k127_6057110_5 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000000000000000000000000000000000003909 165.0
TLS3_k127_6057110_6 helix_turn_helix, mercury resistance K08365 - - 0.000000000000000000000000000003499 132.0
TLS3_k127_6057110_7 Copper binding periplasmic protein CusF - - - 0.000000000000000000003788 97.0
TLS3_k127_6060757_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 1.576e-261 820.0
TLS3_k127_6077207_0 helix_turn_helix, Lux Regulon K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 589.0
TLS3_k127_6077207_1 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005593 424.0
TLS3_k127_6077207_2 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 382.0
TLS3_k127_6077207_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009512 249.0
TLS3_k127_6077207_4 LemA family - - - 0.0000000000000000000000000000000000000000000005827 171.0
TLS3_k127_6081895_0 LUD domain K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 525.0
TLS3_k127_6081895_1 Cysteine-rich domain K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 383.0
TLS3_k127_6081895_2 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 382.0
TLS3_k127_6081895_3 Belongs to the peptidase S11 family K07262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007557 321.0
TLS3_k127_6081895_4 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000003987 111.0
TLS3_k127_6089087_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 457.0
TLS3_k127_6089087_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 444.0
TLS3_k127_6093531_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.653e-313 968.0
TLS3_k127_6093531_1 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 1.244e-269 840.0
TLS3_k127_6093531_2 ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 372.0
TLS3_k127_6098504_0 Atp-dependent helicase K03578 - 3.6.4.13 4.368e-301 942.0
TLS3_k127_6098504_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions - - - 0.000000000000000000000000000006426 126.0
TLS3_k127_6110839_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 450.0
TLS3_k127_6110839_1 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005721 435.0
TLS3_k127_6110839_2 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000001896 272.0
TLS3_k127_6110839_3 Pfam Sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000001917 206.0
TLS3_k127_6110839_4 Flagellar regulatory protein FleQ - - - 0.000000000000000000000008283 104.0
TLS3_k127_6115926_0 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K13896,K15583 - - 6.235e-195 618.0
TLS3_k127_6115926_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 539.0
TLS3_k127_6115926_2 RNA polymerase K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 284.0
TLS3_k127_6115926_3 - - - - 0.00000000000000000000000000000000000000000000001092 180.0
TLS3_k127_6115926_4 PFAM RDD domain containing protein - - - 0.000000000000000000000000008251 115.0
TLS3_k127_6115926_5 Protein of unknown function (DUF3106) - - - 0.00000000000000000000002453 110.0
TLS3_k127_6115926_6 Protein of unknown function (DUF3619) - - - 0.00000000000000001167 90.0
TLS3_k127_6126360_0 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 319.0
TLS3_k127_6126360_1 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009467 246.0
TLS3_k127_6126360_2 PFAM AMP-dependent synthetase and ligase K18661 - - 0.00000000005041 63.0
TLS3_k127_6129754_0 Glycosyl transferase family 21 K00694 - 2.4.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 327.0
TLS3_k127_6129754_1 Glycosyl hydrolases family 8 K20542 - 3.2.1.4 0.00000000000000000000000000000000000000000000002917 181.0
TLS3_k127_6129754_2 Diguanylate cyclase - - - 0.0001108 53.0
TLS3_k127_6143019_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 8.803e-254 790.0
TLS3_k127_6143019_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 454.0
TLS3_k127_6143019_2 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000002771 222.0
TLS3_k127_6143019_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000003457 134.0
TLS3_k127_6151564_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 2.605e-286 898.0
TLS3_k127_6151564_1 Sigma-54 factor interaction domain-containing protein - - - 1.276e-195 619.0
TLS3_k127_6151564_10 PFAM glycosyl transferase group 1 K02844,K14335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007136 342.0
TLS3_k127_6151564_11 Glutaredoxin-family domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 314.0
TLS3_k127_6151564_12 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004819 270.0
TLS3_k127_6151564_13 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001936 277.0
TLS3_k127_6151564_14 Uncharacterized protein conserved in bacteria (DUF2334) K06986 - - 0.000000000000000000000000000000000000000000000000000000003817 215.0
TLS3_k127_6151564_15 HAD-hyrolase-like - - - 0.00000000000000000000000000000000000000000000000000000001822 206.0
TLS3_k127_6151564_16 PFAM PRC-barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000004394 187.0
TLS3_k127_6151564_17 Domain of unknown function (DUF2383) - - - 0.000000000000000000000000000000000000000000000001286 189.0
TLS3_k127_6151564_18 Pfam Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000001617 180.0
TLS3_k127_6151564_19 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000003713 168.0
TLS3_k127_6151564_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.903e-194 617.0
TLS3_k127_6151564_20 OmpA-like transmembrane domain - - - 0.0000000000000000000000000000000000001002 151.0
TLS3_k127_6151564_21 Transglycosylase associated protein - - - 0.000000000000000000000000000000000005284 138.0
TLS3_k127_6151564_22 COG3040 Bacterial lipocalin K03098 - - 0.00000000000000000000000000000004081 136.0
TLS3_k127_6151564_23 - - - - 0.000000000000000000000000000001109 129.0
TLS3_k127_6151564_24 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000248 119.0
TLS3_k127_6151564_25 BON domain K04065 - - 0.00000000000000000000000164 107.0
TLS3_k127_6151564_26 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000000000002216 117.0
TLS3_k127_6151564_27 PRC-barrel domain - - - 0.0000000000000000000001962 109.0
TLS3_k127_6151564_28 PFAM zinc finger, DksA TraR C4-type - - - 0.000000000000000000009936 96.0
TLS3_k127_6151564_29 - - - - 0.00000000000000000002269 95.0
TLS3_k127_6151564_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 612.0
TLS3_k127_6151564_30 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000008532 95.0
TLS3_k127_6151564_31 Histidine kinase - - - 0.00000000000000289 85.0
TLS3_k127_6151564_33 bacterial OsmY and nodulation domain - - - 0.000000001196 68.0
TLS3_k127_6151564_34 - - - - 0.000000005198 66.0
TLS3_k127_6151564_35 - - - - 0.0000001777 56.0
TLS3_k127_6151564_36 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.0000002883 58.0
TLS3_k127_6151564_4 Dead deah box helicase domain protein K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 546.0
TLS3_k127_6151564_5 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 468.0
TLS3_k127_6151564_6 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 477.0
TLS3_k127_6151564_7 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 403.0
TLS3_k127_6151564_8 Phospholipase D Active site motif K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 372.0
TLS3_k127_6151564_9 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008363 342.0
TLS3_k127_6151569_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 481.0
TLS3_k127_6151569_1 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 355.0
TLS3_k127_6151569_2 Domain of unknown function (DUF3329) K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 291.0
TLS3_k127_6151569_3 - - - - 0.0000000000000000000004711 111.0
TLS3_k127_6151569_4 - - - - 0.000000000000433 75.0
TLS3_k127_6155144_0 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 475.0
TLS3_k127_6155144_1 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 359.0
TLS3_k127_6158594_0 DNA ligase K01971 - 6.5.1.1 2.663e-251 789.0
TLS3_k127_6158594_1 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 473.0
TLS3_k127_6158594_2 Major facilitator superfamily MFS_1 K02445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 394.0
TLS3_k127_6158594_3 Belongs to the HpcH HpaI aldolase family K01644,K08691 - 4.1.3.24,4.1.3.25,4.1.3.34 0.0000000000000000000000004165 109.0
TLS3_k127_6160109_0 abc transporter atp-binding protein K06147 - - 3.745e-306 948.0
TLS3_k127_6160109_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009796 508.0
TLS3_k127_6160109_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 391.0
TLS3_k127_6160109_3 Glyoxalase-like domain K04750 - - 0.00000000000000000000000000000000000000000000000000000000000005004 218.0
TLS3_k127_6160109_4 ATP-independent chaperone mediated protein folding - - - 0.00000000000000000000000000000000000000003078 160.0
TLS3_k127_6160109_6 Protein of unknown function (DUF4236) - - - 0.000000000000000005732 96.0
TLS3_k127_6168315_0 Mandelate racemase muconate lactonizing enzyme K01706 - 4.2.1.40 7.776e-236 735.0
TLS3_k127_6168315_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 337.0
TLS3_k127_6168315_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005496 338.0
TLS3_k127_6168315_3 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000003008 186.0
TLS3_k127_6168315_4 Prolyl oligopeptidase, N-terminal beta-propeller domain - - - 0.00000000000000000000000000000000000000000002395 164.0
TLS3_k127_6168315_5 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000000011 59.0
TLS3_k127_6182124_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0 1308.0
TLS3_k127_6182124_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0 1126.0
TLS3_k127_6182124_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 3.856e-204 641.0
TLS3_k127_6182124_3 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 531.0
TLS3_k127_6182124_4 ornithine cyclodeaminase K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004881 276.0
TLS3_k127_6182124_5 SOS response associated peptidase (SRAP) - - - 0.0000000000000000000000000000000000000000000000001135 187.0
TLS3_k127_6182124_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000000000000005466 117.0
TLS3_k127_6182124_7 - - - - 0.00000003771 58.0
TLS3_k127_6182805_0 - K07341 - - 0.000000000000000000000000000000000000006683 149.0
TLS3_k127_6182805_1 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000004573 122.0
TLS3_k127_6183385_0 AMP-binding enzyme K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 351.0
TLS3_k127_6183385_1 PFAM molybdopterin oxidoreductase Fe4S4 region K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009732 292.0
TLS3_k127_6183385_3 Protein of unknown function (DUF3455) - - - 0.0000000000000000000001003 106.0
TLS3_k127_6183385_4 formate dehydrogenase K00123 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050896,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:1902494 1.17.1.9 0.0000000000000002395 78.0
TLS3_k127_6189253_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004224 466.0
TLS3_k127_6189253_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 360.0
TLS3_k127_6189253_2 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 323.0
TLS3_k127_6189253_3 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000007627 200.0
TLS3_k127_6189253_4 Transcriptional regulator, GntR family - - - 0.000000000000000000000000000000000000000000000000003185 190.0
TLS3_k127_6189253_5 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000625 108.0
TLS3_k127_6195217_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 5.789e-309 966.0
TLS3_k127_6197645_0 Non-ribosomal peptide synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 524.0
TLS3_k127_6197645_1 carbamoyl transferase, NodU family K00612,K16035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006641 514.0
TLS3_k127_6197645_2 Phosphopantetheine attachment site - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 482.0
TLS3_k127_6197645_3 PFAM MbtH domain protein K05375,K09190 - - 0.00000000000000000000000000000000000000000000000000000000007427 210.0
TLS3_k127_6199202_0 Protein of unknown function (DUF2891) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 386.0
TLS3_k127_6199202_1 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.000000000000000000000000000000000000000000000000000000003553 209.0
TLS3_k127_620638_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 553.0
TLS3_k127_620638_1 phospholipase K01058 - 3.1.1.32,3.1.1.4 0.0000000000000000003495 87.0
TLS3_k127_6208880_0 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 336.0
TLS3_k127_6208880_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 335.0
TLS3_k127_6208880_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 329.0
TLS3_k127_6213528_0 Malonate decarboxylase, alpha subunit, transporter K01026 - 2.8.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 405.0
TLS3_k127_6213528_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000001778 219.0
TLS3_k127_6245227_0 Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 487.0
TLS3_k127_6245227_1 GTP cyclohydrolase K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 372.0
TLS3_k127_6245227_2 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000003108 235.0
TLS3_k127_6245227_3 PFAM BLUF domain protein - - - 0.00000000000000000000000000000000000000000000000000000000002085 208.0
TLS3_k127_6245227_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000005373 193.0
TLS3_k127_6245227_5 Nuclease (SNase domain protein) - - - 0.000000000000000000000000000000000000000000000006345 177.0
TLS3_k127_6245227_6 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000001018 137.0
TLS3_k127_6245227_7 - - - - 0.00000000000000000000000000000008357 127.0
TLS3_k127_6245227_8 - - - - 0.00000000000000000005984 95.0
TLS3_k127_6257263_0 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 369.0
TLS3_k127_6257263_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001782 273.0
TLS3_k127_6257263_2 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000007227 172.0
TLS3_k127_6277199_0 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 315.0
TLS3_k127_6277199_1 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000847 287.0
TLS3_k127_6277199_2 ATPase (AAA K06923 - - 0.0000000000000000000000000000000000000000000000000000000000002511 214.0
TLS3_k127_6277199_3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000000004721 87.0
TLS3_k127_6279421_0 RNA polymerase sigma factor RpoH K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 310.0
TLS3_k127_6279421_1 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000001105 118.0
TLS3_k127_6291782_0 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 569.0
TLS3_k127_6291782_1 Domain of unknown function (DUF4154) - - - 0.00000000000000000000000000000000002431 143.0
TLS3_k127_6330334_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 2.804e-199 632.0
TLS3_k127_6330334_1 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000001185 111.0
TLS3_k127_6435551_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 5.978e-198 621.0
TLS3_k127_6435551_1 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000624 243.0
TLS3_k127_6463305_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 601.0
TLS3_k127_6463305_1 DNA polymerase III (Delta subunit) K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 370.0
TLS3_k127_6463305_2 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.00000000000000000000000000000000003559 151.0
TLS3_k127_6480848_0 Glutaredoxin K03599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 369.0
TLS3_k127_6480848_1 Cytochrome C1 K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006294 261.0
TLS3_k127_6480848_2 Stringent starvation protein B K03600 - - 0.000000000000000000000000000000000000000000009854 167.0
TLS3_k127_6480848_3 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000002168 81.0
TLS3_k127_6480848_4 - - - - 0.0001944 45.0
TLS3_k127_6526568_0 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006224 403.0
TLS3_k127_6526568_1 beta-lactamase - - - 0.000000000000000000001602 105.0
TLS3_k127_654401_0 Pyridoxal-phosphate dependent enzyme K01697,K01738 - 2.5.1.47,4.2.1.22 7.299e-220 689.0
TLS3_k127_654401_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760,K01761 - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 1.004e-197 638.0
TLS3_k127_654401_10 HIT family hydrolase K02503 - - 0.000000000000000000000008088 107.0
TLS3_k127_654401_11 Hemerythrin HHE cation binding domain - - - 0.00000000000001646 75.0
TLS3_k127_654401_12 PEP-CTERM motif - - - 0.0009972 45.0
TLS3_k127_654401_2 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 416.0
TLS3_k127_654401_3 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 391.0
TLS3_k127_654401_4 Acyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 357.0
TLS3_k127_654401_5 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 314.0
TLS3_k127_654401_6 sulfur dioxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 287.0
TLS3_k127_654401_7 Uncharacterized conserved protein (DUF2183) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001982 261.0
TLS3_k127_654401_8 glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000229 213.0
TLS3_k127_654401_9 PEP-CTERM motif - - - 0.000000000000000000000000001852 117.0
TLS3_k127_6645885_0 protease with the C-terminal PDZ - - - 9.992e-213 676.0
TLS3_k127_6645885_1 Protein of unknown function, DUF599 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 317.0
TLS3_k127_6645885_2 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine K03648 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000195 260.0
TLS3_k127_6645885_3 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.00000000000000000000001147 100.0
TLS3_k127_6645885_4 - - - - 0.0009008 48.0
TLS3_k127_6668896_0 DDE (Asp,Asp,Glu) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 552.0
TLS3_k127_6668896_1 - - - - 0.000000000000000000000000573 108.0
TLS3_k127_6675650_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1285.0
TLS3_k127_6675650_1 fumarate reductase respiratory complex transmembrane subunit K00246 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 327.0
TLS3_k127_6675650_2 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 293.0
TLS3_k127_6675650_3 Fumarate reductase flavoprotein C-term K00244 - 1.3.5.4 0.00000003341 56.0
TLS3_k127_6682401_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1693.0
TLS3_k127_6682401_1 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 550.0
TLS3_k127_6682401_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 403.0
TLS3_k127_6682401_3 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003796 259.0
TLS3_k127_6682401_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000002629 235.0
TLS3_k127_6682401_5 Rhomboid family K19225 - 3.4.21.105 0.0000000000000000001949 93.0
TLS3_k127_6891586_0 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001175 267.0
TLS3_k127_6891586_1 Pyrimidine operon attenuation protein uracil phosphoribosyltransferase K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000116 188.0
TLS3_k127_6891586_2 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000004305 139.0
TLS3_k127_6891586_3 PFAM DNA photolyase, FAD-binding K01669 - 4.1.99.3 0.000000000001433 72.0
TLS3_k127_6891586_4 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000001666 68.0
TLS3_k127_6893290_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 569.0
TLS3_k127_6893290_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 509.0
TLS3_k127_6893290_2 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 284.0
TLS3_k127_6893290_3 MOSC N-terminal beta barrel domain K07140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007375 278.0
TLS3_k127_6893290_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000004895 256.0
TLS3_k127_6893290_5 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007116 247.0
TLS3_k127_6893290_6 Protein of unknown function (DUF418) K07148 - - 0.0000000000000000000000000000000000000000000001216 183.0
TLS3_k127_6896069_0 PFAM AAA ATPase central domain protein K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 435.0
TLS3_k127_6896069_1 ABC-2 family transporter protein K09696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 300.0
TLS3_k127_6896069_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 298.0
TLS3_k127_6896069_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000005538 190.0
TLS3_k127_6896069_4 abc transporter atp-binding protein K09697 - 3.6.3.7 0.000000000000000000000000000000000008244 138.0
TLS3_k127_6896069_5 Type IV pilus biogenesis stability protein PilW - - - 0.0000000000000000000000000000068 129.0
TLS3_k127_6898694_0 FAD linked oxidase domain protein - - - 2.458e-258 807.0
TLS3_k127_6898694_1 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008018 375.0
TLS3_k127_6899288_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 8.396e-309 952.0
TLS3_k127_6899288_1 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 407.0
TLS3_k127_6899288_2 Threonyl alanyl tRNA synthetase K07050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 320.0
TLS3_k127_6899288_3 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 303.0
TLS3_k127_6899288_4 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000191 209.0
TLS3_k127_6903771_0 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015,K00090 - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000005371 157.0
TLS3_k127_6903771_1 acyl-coA-binding protein - - - 0.00000000000000000000000000000005233 130.0
TLS3_k127_6903771_2 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000009296 119.0
TLS3_k127_6903771_3 polyhydroxyalkanoic acid - - - 0.000000000000002322 80.0
TLS3_k127_6906573_0 MltA specific insert domain K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 400.0
TLS3_k127_6906573_1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000000003292 217.0
TLS3_k127_6906573_2 protein affecting Mg2 Co2 transport K06195 - - 0.000000000000000000000000000000000000000000000000000749 186.0
TLS3_k127_6906573_3 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family - - - 0.000000000000004975 76.0
TLS3_k127_6907264_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009623 421.0
TLS3_k127_6907264_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000006343 266.0
TLS3_k127_6907264_2 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000002717 200.0
TLS3_k127_6907264_3 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.0000000000000000000000168 108.0
TLS3_k127_6907264_4 - - - - 0.00004098 46.0
TLS3_k127_6921863_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008182 593.0
TLS3_k127_6921863_1 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009772 247.0
TLS3_k127_6928817_0 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 416.0
TLS3_k127_6928817_1 PFAM regulatory protein, MerR K22491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 287.0
TLS3_k127_6928817_2 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002852 256.0
TLS3_k127_6928817_3 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000000000000000000000741 208.0
TLS3_k127_6928817_4 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000005402 205.0
TLS3_k127_6928817_5 Domain of unknown function (DUF378) K09779 - - 0.000000000000006194 77.0
TLS3_k127_6934750_0 Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway K03181 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009273,GO:0009987,GO:0016043,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0022607,GO:0032787,GO:0042546,GO:0043436,GO:0043648,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0072330,GO:1901576 4.1.3.40 0.00000000000000000000000000000000000002339 150.0
TLS3_k127_6934750_1 thiosulfate sulfurtransferase activity - - - 0.0000000000000000000000005302 106.0
TLS3_k127_6946316_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006046 299.0
TLS3_k127_6946316_1 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000002818 218.0
TLS3_k127_6946316_2 2-phosphosulfolactate phosphatase activity K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.0000000000000000000000000000000000000000000000000000000007236 209.0
TLS3_k127_6946316_3 Alpha beta hydrolase - - - 0.0003166 44.0
TLS3_k127_6946316_4 electron transfer activity K03737,K05337 - 1.2.7.1 0.0007189 53.0
TLS3_k127_6952806_0 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 563.0
TLS3_k127_6952806_1 Belongs to the HypD family K04654 - - 0.000000000000000000000000000000000000000000000000000000000003522 213.0
TLS3_k127_6952806_2 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000000000000006394 106.0
TLS3_k127_6954384_0 Belongs to the ABC transporter superfamily K02031,K16202 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 475.0
TLS3_k127_6954384_1 DoxX K15977 - - 0.00000000000000000000000000006498 120.0
TLS3_k127_6954384_2 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.00000000000000000000000001799 118.0
TLS3_k127_6967348_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 4.583e-216 679.0
TLS3_k127_6967348_1 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 370.0
TLS3_k127_6967348_2 Tricorn protease C1 domain K03797 - 3.4.21.102 0.00000000000000000000000000000000004235 151.0
TLS3_k127_6967348_3 Protein of unknown function (DUF3618) - - - 0.0000000000000000000000000000000007713 142.0
TLS3_k127_6967348_4 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000000000000000000009841 112.0
TLS3_k127_6967348_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000007853 98.0
TLS3_k127_6967348_6 - - - - 0.0000000000001091 79.0
TLS3_k127_6970832_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008381 597.0
TLS3_k127_6970832_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 444.0
TLS3_k127_6970832_2 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000001322 203.0
TLS3_k127_6970832_3 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000008399 143.0
TLS3_k127_6973208_0 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 392.0
TLS3_k127_6973208_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005049 285.0
TLS3_k127_6973208_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003207 273.0
TLS3_k127_6973208_3 Rhodanese-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003159 228.0
TLS3_k127_6973208_4 HlyD membrane-fusion protein of T1SS K13408 - - 0.000000000000004287 83.0
TLS3_k127_6986318_0 - - - - 0.000000000000000000000000000000000000000000000000000007296 195.0
TLS3_k127_6986318_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000002386 169.0
TLS3_k127_6988240_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 548.0
TLS3_k127_6988240_1 HAD-superfamily hydrolase, subfamily IB, PSPase-like - - - 0.000000000000000000000000000000000000000000000000000000000000001647 225.0
TLS3_k127_6988240_2 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000145 203.0
TLS3_k127_6988240_3 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000003739 154.0
TLS3_k127_6988240_4 Belongs to the DnaA family K10763 - - 0.0000000000000000000000000000000001643 135.0
TLS3_k127_7000944_0 LysM domain K08086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 439.0
TLS3_k127_7000944_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005936 304.0
TLS3_k127_7000944_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004676 266.0
TLS3_k127_7000944_3 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000002354 65.0
TLS3_k127_7001243_0 His Kinase A (phospho-acceptor) domain - - - 0.0 1181.0
TLS3_k127_7001243_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1145.0
TLS3_k127_7001243_2 Exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 591.0
TLS3_k127_7001243_3 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 411.0
TLS3_k127_7001243_4 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000004028 225.0
TLS3_k127_7001243_5 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000001659 156.0
TLS3_k127_7001243_6 - - - - 0.00000000000614 72.0
TLS3_k127_7001823_0 Tripartite tricarboxylate transporter TctA family K07793 - - 4.429e-215 682.0
TLS3_k127_7001823_1 Ammonia monooxygenase K07120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 333.0
TLS3_k127_7001823_2 PFAM Tripartite tricarboxylate transporter family receptor K07795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 292.0
TLS3_k127_7001823_3 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000009215 107.0
TLS3_k127_7001823_4 Tripartite tricarboxylate transporter TctB family - - - 0.000000000000000000002045 100.0
TLS3_k127_7004842_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 429.0
TLS3_k127_7004842_1 Cupin domain - - - 0.00000000000000000000000000000000000000000001289 168.0
TLS3_k127_7004842_2 Histidine kinase K20974 - 2.7.13.3 0.0000000000000000001671 92.0
TLS3_k127_7008718_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008143 314.0
TLS3_k127_7008718_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.00000000000000000000000000000000000000000000000000006949 188.0
TLS3_k127_7008718_2 ANTAR K22010 - - 0.00000000000000000000000000000000000000000000001204 178.0
TLS3_k127_7008718_3 - - - - 0.00000000000007352 78.0
TLS3_k127_7061250_0 Calcineurin-like phosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000006705 211.0
TLS3_k127_7061250_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.00000000000000000000000000000000000000000001089 167.0
TLS3_k127_7061250_2 TraB family K09973 - - 0.0000000000000000000000000000000000000000004125 168.0
TLS3_k127_7065307_0 Glycine-zipper domain - - - 0.00000000000000000000000000000000000009597 149.0
TLS3_k127_7065307_1 MgtC family K07507 - - 0.00000000000000000000806 95.0
TLS3_k127_7065307_2 - - - - 0.0000000000000000000242 98.0
TLS3_k127_7075350_0 AAA domain K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 543.0
TLS3_k127_7075350_1 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 345.0
TLS3_k127_7078743_0 Putative citrate transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 411.0
TLS3_k127_7078743_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00090 - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 343.0
TLS3_k127_7095922_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 557.0
TLS3_k127_7095922_1 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002109 293.0
TLS3_k127_7095922_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000009603 87.0
TLS3_k127_7104406_0 2-methylcitrate dehydratase K01720 - 4.2.1.79 1.592e-232 730.0
TLS3_k127_7104406_1 also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity K01659 - 2.3.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 310.0
TLS3_k127_7104406_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000003602 207.0
TLS3_k127_7108988_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 381.0
TLS3_k127_7108988_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 358.0
TLS3_k127_71124_0 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000229 273.0
TLS3_k127_71124_1 Protein of unknown function (DUF3426) - - - 0.000000000000000000008122 104.0
TLS3_k127_7129956_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 518.0
TLS3_k127_7129956_1 DNA helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 308.0
TLS3_k127_7141459_0 Outer membrane receptor proteins mostly Fe transport - - - 0.0 1049.0
TLS3_k127_7141459_1 Belongs to the IlvD Edd family K01690 - 4.2.1.12 8.388e-312 966.0
TLS3_k127_7141459_2 Common central domain of tyrosinase K00505 - 1.14.18.1 9.315e-204 646.0
TLS3_k127_7141459_3 Belongs to the bacterial glucokinase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 437.0
TLS3_k127_7141459_4 Aldolase K01625 - 4.1.2.14,4.1.3.42 0.00000000000000000000000000000000000000000000000000000000000000000000000001613 266.0
TLS3_k127_7141459_5 6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000007366 246.0
TLS3_k127_7141459_6 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000000000000000000000000000001448 206.0
TLS3_k127_7141459_7 Excalibur calcium-binding domain - - - 0.0000000000000000000000000000003764 127.0
TLS3_k127_7141459_8 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000001029 115.0
TLS3_k127_7141459_9 - - - - 0.0000000000000000000000005668 111.0
TLS3_k127_715455_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 547.0
TLS3_k127_715455_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003278 326.0
TLS3_k127_715455_2 negative regulator of sigma E activity K03598 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003046 259.0
TLS3_k127_715455_3 Anti sigma-E protein RseA, N-terminal domain K03597 - - 0.0000000000000008472 87.0
TLS3_k127_7171494_0 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 318.0
TLS3_k127_7171494_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009511 308.0
TLS3_k127_7171494_2 Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 288.0
TLS3_k127_7171494_3 Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02403 - - 0.00000000000000000000000000000004047 128.0
TLS3_k127_7171494_4 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.0000000000000000000000000005279 124.0
TLS3_k127_7171494_5 Flagellar protein FliT K02423 - - 0.000000002486 64.0
TLS3_k127_7179579_0 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 504.0
TLS3_k127_7179579_1 Haem-degrading K11477 - - 0.00000000000000000000000000000000000000000000000000007947 190.0
TLS3_k127_7179579_2 DUF218 domain - - - 0.0000000000000000000000000000000000000000000008858 174.0
TLS3_k127_7210791_0 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 289.0
TLS3_k127_7210791_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000003471 216.0
TLS3_k127_7210791_2 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA K02517 - 2.3.1.241 0.000000000000000000000000000000000008132 138.0
TLS3_k127_7224141_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 5.723e-249 778.0
TLS3_k127_7243860_0 acyl-CoA dehydrogenase - - - 2.823e-281 880.0
TLS3_k127_7243860_1 3-hydroxyacyl-coa dehydrogenase K07516 - 1.1.1.35 9.599e-220 687.0
TLS3_k127_7243860_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001834 282.0
TLS3_k127_7243860_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000003485 231.0
TLS3_k127_7243860_4 PFAM DoxX family protein K15977 - - 0.0000000000000000000002958 98.0
TLS3_k127_7259647_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 293.0
TLS3_k127_7259647_1 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000009303 125.0
TLS3_k127_7269416_0 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 393.0
TLS3_k127_7269416_1 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000922 247.0
TLS3_k127_7269416_2 Sodium hydrogen exchanger K11105 - - 0.0000000000000000000000000007214 121.0
TLS3_k127_7292396_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 4.83e-232 728.0
TLS3_k127_7292396_1 Belongs to the transcriptional regulatory Fis family K03557 - - 0.0000000000856 62.0
TLS3_k127_7292396_2 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0002688 44.0
TLS3_k127_7296106_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 507.0
TLS3_k127_7296106_1 PFAM Aldehyde dehydrogenase family K00128,K00131,K00146,K00151,K10217 - 1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.60,1.2.1.85,1.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 480.0
TLS3_k127_7296106_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 399.0
TLS3_k127_7306354_0 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001236 267.0
TLS3_k127_7306354_1 SMART Transport-associated and nodulation region - - - 0.0000000000000000000000000000000000000000000005886 178.0
TLS3_k127_7306354_2 LppC putative lipoprotein K07121 - - 0.0000000000000000000000000000000000000000007788 171.0
TLS3_k127_7306354_3 Peptidase family M48 - - - 0.00000000000000000000000000000000000000002425 157.0
TLS3_k127_7306354_4 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000000001618 124.0
TLS3_k127_73091_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 475.0
TLS3_k127_73091_1 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000002 213.0
TLS3_k127_73091_2 PFAM aminotransferase class I and II K14267 - 2.6.1.17 0.00000000000000000000000000000000000000000000000000000000009741 207.0
TLS3_k127_7333305_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 3.173e-254 794.0
TLS3_k127_7333305_1 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000003118 229.0
TLS3_k127_7333305_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481,K02667 - - 0.00000006238 55.0
TLS3_k127_7361604_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 587.0
TLS3_k127_7361604_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 355.0
TLS3_k127_7361604_2 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 354.0
TLS3_k127_7361604_3 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000000000000000000004161 215.0
TLS3_k127_7361604_4 Required for insertion of 4Fe-4S clusters K15724 - - 0.0000000000000000000000000000000000000000000000000000000004717 205.0
TLS3_k127_7361604_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000001244 93.0
TLS3_k127_7361604_6 phosphatidylethanolamine-binding protein K06910 - - 0.0003978 48.0
TLS3_k127_7384177_0 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 584.0
TLS3_k127_7384177_1 Transport of potassium into the cell K03549 - - 0.0000000000000000000000000000000000000000000000000000000000000001944 227.0
TLS3_k127_7398980_0 DNA ligase K01971 - 6.5.1.1 0.0 1240.0
TLS3_k127_7398980_1 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 306.0
TLS3_k127_7398980_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000001576 228.0
TLS3_k127_7413161_0 Belongs to the peptidase M16 family K07263 - - 8.244e-240 757.0
TLS3_k127_7413161_1 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000001584 235.0
TLS3_k127_7413161_2 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000007121 175.0
TLS3_k127_7413161_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000005649 165.0
TLS3_k127_747181_0 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 396.0
TLS3_k127_747181_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 334.0
TLS3_k127_747181_2 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000000000000000000001617 219.0
TLS3_k127_747181_3 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000003431 52.0
TLS3_k127_7484537_0 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004399 269.0
TLS3_k127_7484537_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006435 254.0
TLS3_k127_7484537_2 PFAM EAL domain, GGDEF domain - - - 0.00000000000000000000000000000000005322 141.0
TLS3_k127_7484537_4 PFAM GGDEF domain containing protein - - - 0.0007768 49.0
TLS3_k127_7500569_0 receptor K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001686 276.0
TLS3_k127_7500569_1 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - 0.000000000000000000002513 100.0
TLS3_k127_7500569_2 - - - - 0.000695 46.0
TLS3_k127_7567175_0 Cobalamin biosynthesis protein CobW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 509.0
TLS3_k127_7567175_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007428 352.0
TLS3_k127_7567175_2 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000002654 238.0
TLS3_k127_7567175_3 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000003497 233.0
TLS3_k127_7567175_4 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000005908 182.0
TLS3_k127_7567175_5 Protein of unknown function (DUF3299) K09950 - - 0.000000000000000000000001469 108.0
TLS3_k127_7567175_6 - - - - 0.000000000006227 76.0
TLS3_k127_7595833_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 316.0
TLS3_k127_7595833_1 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004196 271.0
TLS3_k127_7648065_0 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 597.0
TLS3_k127_7648065_1 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 514.0
TLS3_k127_7648065_2 Dehydrogenase K00285 - 1.4.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 486.0
TLS3_k127_7648065_3 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 406.0
TLS3_k127_7648065_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.0000000000000000000000000000000000000000000000000000000000000000000008902 253.0
TLS3_k127_7648065_5 Tripartite ATP-independent periplasmic transporter DctQ component - - - 0.000000000000000000000000000000004354 134.0
TLS3_k127_7658131_0 CRP FNR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003504 263.0
TLS3_k127_7658131_1 AI-2E family transporter - - - 0.0000000000000000000000000000000000000003194 150.0
TLS3_k127_7658131_2 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000001782 151.0
TLS3_k127_7658131_3 Transcriptional regulatory protein, C terminal K07666 - - 0.000000000000000000000000000000001964 132.0
TLS3_k127_7663235_0 TIGRFAM chorismate mutase domain of proteobacterial P-protein, clade 2 K01713,K14170 - 4.2.1.51,4.2.1.91,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 466.0
TLS3_k127_7663235_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000008747 225.0
TLS3_k127_7748538_0 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 599.0
TLS3_k127_7748538_1 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 576.0
TLS3_k127_7748538_10 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00001591 47.0
TLS3_k127_7748538_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 424.0
TLS3_k127_7748538_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 355.0
TLS3_k127_7748538_4 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 344.0
TLS3_k127_7748538_5 branched-chain amino acid K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 298.0
TLS3_k127_7748538_6 PFAM peptidase U61, LD-carboxypeptidase A K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004244 285.0
TLS3_k127_7748538_7 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000000007614 236.0
TLS3_k127_7748538_8 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000548 208.0
TLS3_k127_7748538_9 Tetratricopeptide repeat - - - 0.000000000000000000000003192 117.0
TLS3_k127_7755266_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 4.519e-197 619.0
TLS3_k127_7755266_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 409.0
TLS3_k127_7755266_2 NlpB/DapX lipoprotein K07287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 372.0
TLS3_k127_7755266_3 PFAM Cupin 4 family protein K18850 - 1.14.11.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008655 358.0
TLS3_k127_7755266_4 beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005692 254.0
TLS3_k127_7755266_5 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.00000000000000000000000000000000000000000000000000000000006175 209.0
TLS3_k127_7755266_6 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000001121 201.0
TLS3_k127_7755266_7 peptidyl-prolyl K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000008788 165.0
TLS3_k127_7757954_0 Riboflavin synthase K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000003628 244.0
TLS3_k127_7757954_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000258 213.0
TLS3_k127_7757954_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000001801 147.0
TLS3_k127_7765369_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.068e-288 900.0
TLS3_k127_7765369_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 311.0
TLS3_k127_7765369_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000002845 181.0
TLS3_k127_7772068_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 572.0
TLS3_k127_7772068_1 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 481.0
TLS3_k127_7772068_2 Bacterial protein of unknown function (DUF922) - - - 0.0003805 51.0
TLS3_k127_7775295_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 439.0
TLS3_k127_7775295_1 PFAM ATP-binding region, ATPase domain protein K07641 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 428.0
TLS3_k127_7775295_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 313.0
TLS3_k127_7775295_3 Transcriptional regulatory protein, C terminal K07663 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004832 281.0
TLS3_k127_7775295_4 response regulator - - - 0.0000000000000000000000000000000000000000000000001277 185.0
TLS3_k127_7775295_5 GGDEF domain - - - 0.00000000000000000000000000000000000000000003442 176.0
TLS3_k127_7775295_6 - - - - 0.000000000000000002513 94.0
TLS3_k127_7775295_7 Domain of unknown function (DUF1840) - - - 0.000000000000000004927 89.0
TLS3_k127_7784391_0 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 325.0
TLS3_k127_7784391_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000003934 205.0
TLS3_k127_7784391_2 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000008177 203.0
TLS3_k127_7804507_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 394.0
TLS3_k127_7804507_1 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000002094 186.0
TLS3_k127_7804507_2 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000007854 181.0
TLS3_k127_7806543_0 Dehydrogenase E1 component K00164 - 1.2.4.2 3.177e-218 681.0
TLS3_k127_7806543_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 309.0
TLS3_k127_7809685_0 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 325.0
TLS3_k127_7809685_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000002904 113.0
TLS3_k127_7809685_2 Major facilitator Superfamily - - - 0.00002839 55.0
TLS3_k127_7814117_0 Hemolysin III K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007258 319.0
TLS3_k127_7814117_1 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 313.0
TLS3_k127_7814117_2 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000005519 220.0
TLS3_k127_7814117_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000004054 173.0
TLS3_k127_7814117_4 Helix-turn-helix - - - 0.0000000000000000000000000000019 127.0
TLS3_k127_7814238_0 peptidylprolyl isomerase K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 490.0
TLS3_k127_7814238_1 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA K06917 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 402.0
TLS3_k127_7814238_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000976 366.0
TLS3_k127_7814238_3 PFAM lipolytic protein G-D-S-L family K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000006864 239.0
TLS3_k127_7814238_4 ABC-type transport system involved in lysophospholipase L1 biosynthesis ATPase component K02003 - - 0.000000000000000000000000000000000000000002137 161.0
TLS3_k127_7814238_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000000000001001 156.0
TLS3_k127_7815916_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.228e-252 794.0
TLS3_k127_7815916_1 ABC-type dipeptide transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 341.0
TLS3_k127_7815916_2 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000003935 95.0
TLS3_k127_7822811_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 312.0
TLS3_k127_7824181_0 Metal-dependent amidase aminoacylase carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 566.0
TLS3_k127_7824181_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 497.0
TLS3_k127_7824181_2 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 480.0
TLS3_k127_7824181_3 Extracellular solute-binding protein, family 5 middle family protein K02035 - - 0.00000000000000000000000000000000000000000000000000000000000005682 216.0
TLS3_k127_7834897_0 AcrB/AcrD/AcrF family K07787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 300.0
TLS3_k127_7834897_1 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.000000000000000000000000000000000001331 153.0
TLS3_k127_7841004_0 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 294.0
TLS3_k127_7841004_1 Fatty acid desaturase K00496 - 1.14.15.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000009389 270.0
TLS3_k127_7841004_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002075 261.0
TLS3_k127_7841004_3 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.000000000000000000000002375 103.0
TLS3_k127_7845723_0 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 422.0
TLS3_k127_7845723_1 protein conserved in bacteria K09790 - - 0.00000000000000000000000000000000000523 142.0
TLS3_k127_7845723_2 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000003731 124.0
TLS3_k127_7845723_3 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000006495 104.0
TLS3_k127_7852343_0 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 1.633e-253 786.0
TLS3_k127_7852343_1 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000000000002571 193.0
TLS3_k127_7852343_2 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000002136 157.0
TLS3_k127_7862198_0 Glycosyl transferases group 1 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 411.0
TLS3_k127_7862198_1 UDP binding domain K00066 - 1.1.1.132 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 340.0
TLS3_k127_7865453_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 6.039e-252 784.0
TLS3_k127_7865453_1 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.000001105 51.0
TLS3_k127_7871524_0 homolog of phage Mu protein gp47 - - - 0.0 1122.0
TLS3_k127_7871524_1 Domain of unknown function (DUF4157) - - - 1.021e-308 963.0
TLS3_k127_7871524_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002775 284.0
TLS3_k127_7871524_11 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000000000000000000000004591 228.0
TLS3_k127_7871524_12 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000229 235.0
TLS3_k127_7871524_13 Protein of unknown function (DUF4255) - - - 0.000000000000000000000000000000000000000000000000000000000004992 219.0
TLS3_k127_7871524_14 PFAM Peptidoglycan-binding - - - 0.00000000000000000000000000000000000000000000000000000000225 207.0
TLS3_k127_7871524_15 Phage baseplate assembly protein W K06903 - - 0.000000000000000000000000000000000000000000000000000000004862 201.0
TLS3_k127_7871524_16 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000000000001197 197.0
TLS3_k127_7871524_17 - - - - 0.00000000000000000000000000000000000000000005283 162.0
TLS3_k127_7871524_18 PAAR motif - - - 0.00000000000000000000000000000000000001454 150.0
TLS3_k127_7871524_19 - - - - 0.00000000000000000000000000006738 126.0
TLS3_k127_7871524_2 Phage tail sheath protein K06907 - - 3.38e-232 741.0
TLS3_k127_7871524_20 - - - - 0.0000000000000000000002039 103.0
TLS3_k127_7871524_3 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 630.0
TLS3_k127_7871524_4 Phage protein D K06905 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 551.0
TLS3_k127_7871524_5 Baseplate J-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008138 457.0
TLS3_k127_7871524_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 446.0
TLS3_k127_7871524_7 Tail protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 378.0
TLS3_k127_7871524_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 295.0
TLS3_k127_7871524_9 Rhs Element Vgr Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002315 283.0
TLS3_k127_7886970_0 acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 560.0
TLS3_k127_7886970_1 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 507.0
TLS3_k127_7886970_2 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.13.11.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004909 387.0
TLS3_k127_7886970_3 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 287.0
TLS3_k127_7886970_4 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K09461 - 1.14.13.40 0.0000000000000000000000000000000000000000000000001283 185.0
TLS3_k127_7886970_5 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000002842 177.0
TLS3_k127_7914361_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.377e-289 891.0
TLS3_k127_7914361_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.445e-279 862.0
TLS3_k127_7914361_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 486.0
TLS3_k127_7914361_3 TonB-dependent receptor plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 375.0
TLS3_k127_7914361_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000000000000000000000007266 178.0
TLS3_k127_7914361_5 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000009697 130.0
TLS3_k127_7931687_0 signal transduction protein containing EAL and modified HD-GYP domains - - - 0.0000000000000000000000000000000000001784 156.0
TLS3_k127_7931687_1 DNA topoisomerase iii K03169 - 5.99.1.2 0.0000000000000000000000000000006076 127.0
TLS3_k127_7931687_2 Protein of unknown function (DUF2905) - - - 0.000000000000000000000000179 106.0
TLS3_k127_7936011_0 Domain of unknown function (DUF4398) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006369 284.0
TLS3_k127_7936011_1 Domain of unknown function (DUF4398) - - - 0.000000003071 65.0
TLS3_k127_7947633_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.929e-203 644.0
TLS3_k127_7947633_1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 419.0
TLS3_k127_7947633_2 phosphoribosyltransferase K07101 - - 0.0000000000000000000000000000000000000000000000000000000006889 207.0
TLS3_k127_7965687_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 5.128e-204 644.0
TLS3_k127_7965687_1 Phenylacetate-CoA oxygenase subunit PaaA K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 576.0
TLS3_k127_7965687_10 Phenylacetate-CoA oxygenase subunit PaaB K02610 - - 0.00000000000000000000000000000000000000000000000000002059 189.0
TLS3_k127_7965687_11 phenylacetic acid degradation protein K02614 - - 0.000000000000000000000000000000000000000000000000007836 184.0
TLS3_k127_7965687_12 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.000000000003112 75.0
TLS3_k127_7965687_2 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 571.0
TLS3_k127_7965687_3 Belongs to the thiolase family K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008018 563.0
TLS3_k127_7965687_4 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 K02613 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006082 501.0
TLS3_k127_7965687_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 444.0
TLS3_k127_7965687_6 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 340.0
TLS3_k127_7965687_7 Pfam:DUF59 K02612 - - 0.000000000000000000000000000000000000000000000000000000000000000001933 233.0
TLS3_k127_7965687_8 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000001036 226.0
TLS3_k127_7965687_9 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000004975 218.0
TLS3_k127_7978393_0 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 496.0
TLS3_k127_7978393_1 Belongs to the HypD family K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 484.0
TLS3_k127_7980422_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 584.0
TLS3_k127_7980422_1 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000000000000000000000000000000000000000001288 182.0
TLS3_k127_7980422_2 Tetratricopeptide repeat K02200 - - 0.00000000000000000000001526 113.0
TLS3_k127_7991536_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 2.937e-205 658.0
TLS3_k127_7991536_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 517.0
TLS3_k127_7991536_2 Outer membrane receptor proteins mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000002446 224.0
TLS3_k127_7991536_3 TonB family K03832 - - 0.000000000000000000000007892 108.0
TLS3_k127_7991536_4 PFAM Cytochrome c, class I - - - 0.0000000000000000000008495 96.0
TLS3_k127_7991536_5 Belongs to the UPF0235 family K09131 - - 0.0000000000000000156 87.0
TLS3_k127_8039950_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 370.0
TLS3_k127_8039950_1 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003613 269.0
TLS3_k127_8039950_2 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007806 273.0
TLS3_k127_8039950_3 - - - - 0.000000000000000000001443 96.0
TLS3_k127_8044389_0 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 2.819e-288 898.0
TLS3_k127_8044389_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03669 - - 1.06e-199 636.0
TLS3_k127_8044389_2 Cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001581 264.0
TLS3_k127_8044389_3 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000001266 201.0
TLS3_k127_8044389_4 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000001036 186.0
TLS3_k127_8088445_0 Bacterial pre-peptidase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 485.0
TLS3_k127_8088445_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 355.0
TLS3_k127_8088445_2 - - - - 0.00000000000000000000000000000000000004249 146.0
TLS3_k127_8089368_0 Fumarate reductase flavoprotein C-term K00244 - 1.3.5.4 3.322e-306 945.0
TLS3_k127_8089368_1 fumarate reductase respiratory complex transmembrane subunit K00246 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 329.0
TLS3_k127_8089368_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 316.0
TLS3_k127_8100195_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 577.0
TLS3_k127_8100195_1 Histidine kinase K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000211 297.0
TLS3_k127_8100195_2 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001744 238.0
TLS3_k127_8100195_3 Transglycosylase associated protein - - - 0.000000000000000000000000000000000000008738 146.0
TLS3_k127_8100195_4 Endoribonuclease L-PSP - - - 0.000000000000000000000000473 105.0
TLS3_k127_8114385_0 Divalent heavy-metal cations transporter K16267 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002328 273.0
TLS3_k127_8114385_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000124 226.0
TLS3_k127_8114385_2 COG0412 Dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000008899 191.0
TLS3_k127_8154056_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 426.0
TLS3_k127_8169071_0 IG-like fold at C-terminal of FixG, putative oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 591.0
TLS3_k127_8169071_1 HemN C-terminal domain - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 490.0
TLS3_k127_8169071_2 Bacterial regulatory proteins, crp family K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000928 352.0
TLS3_k127_8169071_3 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.00000000000000000000000117 104.0
TLS3_k127_8169071_4 - - - - 0.00000000000000000000000164 107.0
TLS3_k127_8169071_5 FixH family K09926 - - 0.000000000000000000008271 104.0
TLS3_k127_8185134_0 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 329.0
TLS3_k127_8185134_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000002298 243.0
TLS3_k127_8185134_2 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000002241 229.0
TLS3_k127_8185134_3 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000003338 189.0
TLS3_k127_8185134_4 Peptidase dimerisation domain - - - 0.00000000000000000000000000008275 116.0
TLS3_k127_8185183_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 534.0
TLS3_k127_8185183_1 COG0464 ATPases of the AAA class - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 454.0
TLS3_k127_8185183_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 419.0
TLS3_k127_8185183_3 abc transporter K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 307.0
TLS3_k127_8185183_4 His Kinase A (phosphoacceptor) domain - - - 0.00000001467 68.0
TLS3_k127_8185183_5 Histidine kinase - - - 0.0003199 53.0
TLS3_k127_820039_0 Orn Lys Arg decarboxylase K01582,K01584 - 4.1.1.18,4.1.1.19 0.0 1226.0
TLS3_k127_820039_1 cell septum assembly - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004677 262.0
TLS3_k127_8224623_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 9.465e-211 672.0
TLS3_k127_8224623_1 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 597.0
TLS3_k127_8224623_2 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005197 401.0
TLS3_k127_8224623_3 PGAP1-like protein - - - 0.0000000000000000000000000000000000000000512 166.0
TLS3_k127_8226353_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009084 521.0
TLS3_k127_8226353_1 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 382.0
TLS3_k127_8226353_2 Aerotolerance regulator N-terminal K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007083 317.0
TLS3_k127_8226353_3 peptidase S1 and S6, chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008829 279.0
TLS3_k127_8226353_4 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000001799 151.0
TLS3_k127_8328662_0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000001355 263.0
TLS3_k127_8328662_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000001137 173.0
TLS3_k127_8328662_2 LppC putative lipoprotein K07121 - - 0.0000000000002545 82.0
TLS3_k127_8339636_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 477.0
TLS3_k127_8343926_0 Acyclic terpene utilisation family protein AtuA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 446.0
TLS3_k127_8343926_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 343.0
TLS3_k127_8343926_2 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 336.0
TLS3_k127_8343926_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000008497 229.0
TLS3_k127_8343926_4 - - - - 0.000000000000000000000000000000000000001319 150.0
TLS3_k127_8343926_5 TRAP transporter solute receptor TAXI family K07080 - - 0.00000000000000000000001424 110.0
TLS3_k127_8412945_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 432.0
TLS3_k127_8412945_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000003829 269.0
TLS3_k127_8412945_2 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000037 190.0
TLS3_k127_8542581_0 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 421.0
TLS3_k127_8542581_1 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000003203 229.0
TLS3_k127_862288_0 Asparagine synthase K01953 - 6.3.5.4 8.519e-208 653.0
TLS3_k127_862288_1 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000001965 85.0
TLS3_k127_871692_0 PFAM Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 594.0
TLS3_k127_871692_1 Protein of unknown function, DUF480 K09915 - - 0.0000000000000000000000000000000000000000000000000000000000000000009876 234.0
TLS3_k127_871692_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000499 169.0
TLS3_k127_876317_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.618e-239 754.0
TLS3_k127_876317_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 8.208e-198 622.0
TLS3_k127_876317_2 COG0569 K transport systems, NAD-binding component K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 556.0
TLS3_k127_876317_3 Tripartite ATP-independent periplasmic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008726 336.0
TLS3_k127_876317_4 Regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001553 280.0
TLS3_k127_876317_5 Histidine kinase - - - 0.000000000000000000000000008733 111.0
TLS3_k127_876996_0 Glycosyl hydrolases family 2, sugar binding domain K01190 - 3.2.1.23 0.0 1007.0
TLS3_k127_876996_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.58e-292 908.0
TLS3_k127_876996_2 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 447.0
TLS3_k127_876996_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002809 271.0
TLS3_k127_876996_4 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000000000000000000000002547 198.0
TLS3_k127_881224_0 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007029 256.0
TLS3_k127_881224_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000004983 227.0
TLS3_k127_881224_2 general stress protein 26 - - - 0.00000000000000000000000000000000000000000000000000002452 206.0
TLS3_k127_881224_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000002712 173.0
TLS3_k127_881224_4 - - - - 0.000000000000000000000000000000000000006139 151.0
TLS3_k127_881224_5 - - - - 0.000000000000000000000000008611 109.0
TLS3_k127_881224_6 Cupin 2, conserved barrel domain protein K21700 - - 0.00000000000000000000005942 103.0
TLS3_k127_881224_7 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000003046 97.0
TLS3_k127_881224_8 Histidine kinase - - - 0.0000000001142 74.0
TLS3_k127_883070_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 387.0
TLS3_k127_883070_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 327.0
TLS3_k127_883070_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000004564 233.0
TLS3_k127_883070_3 SpoU rRNA Methylase family K03437 - - 0.000000000000000000000000000000000000000000000000000001215 203.0
TLS3_k127_883070_4 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000002367 70.0
TLS3_k127_886908_0 Belongs to the peptidase S8 family - - - 9.999e-220 704.0
TLS3_k127_886908_1 Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000000000000000000000000000000000008395 228.0
TLS3_k127_886908_2 Domain of unknown function (DUF4440) - - - 0.000000000000000000000001589 105.0
TLS3_k127_886908_3 LysM domain - - - 0.0000000000000000000002038 106.0
TLS3_k127_886908_4 Astacin (Peptidase family M12A) - - - 0.0000002692 53.0
TLS3_k127_886908_5 Calcium/calmodulin dependent protein kinase II association domain - - - 0.0002447 49.0
TLS3_k127_888247_0 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 2.614e-208 669.0
TLS3_k127_888247_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 376.0
TLS3_k127_888247_2 signal peptide protein - - - 0.000000000000000000000000000000000000000000001085 171.0
TLS3_k127_888247_3 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000001239 167.0
TLS3_k127_891338_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 425.0
TLS3_k127_891338_1 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 339.0
TLS3_k127_891338_2 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 318.0
TLS3_k127_891338_3 CHAT domain - - - 0.000000000000000000000000000000000000000000000000004358 182.0
TLS3_k127_905719_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 496.0
TLS3_k127_905719_1 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000000002024 141.0
TLS3_k127_905719_2 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000002608 75.0
TLS3_k127_905719_3 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000002409 63.0
TLS3_k127_908479_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1349.0
TLS3_k127_908479_1 surface antigen (D15) K07278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 425.0
TLS3_k127_908479_2 protein conserved in bacteria K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 438.0
TLS3_k127_908479_3 Conserved TM helix - - - 0.00000000000004525 77.0
TLS3_k127_912464_0 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 338.0
TLS3_k127_912464_1 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000002322 222.0
TLS3_k127_912464_2 cell division K03586 GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944 - 0.000000001669 66.0
TLS3_k127_923954_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008718 353.0
TLS3_k127_923954_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 321.0
TLS3_k127_923954_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000603 271.0
TLS3_k127_923954_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000001393 93.0
TLS3_k127_924953_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 1.439e-299 938.0
TLS3_k127_924953_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 4.09e-262 823.0
TLS3_k127_924953_10 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000005583 179.0
TLS3_k127_924953_11 Belongs to the skp family K06142 - - 0.00003714 49.0
TLS3_k127_924953_2 Metallopeptidase family M24 K01265 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 463.0
TLS3_k127_924953_3 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 435.0
TLS3_k127_924953_4 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 423.0
TLS3_k127_924953_5 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003999 417.0
TLS3_k127_924953_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009527 389.0
TLS3_k127_924953_7 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 377.0
TLS3_k127_924953_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 312.0
TLS3_k127_924953_9 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000121 278.0
TLS3_k127_932021_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007878 567.0
TLS3_k127_932021_1 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000625 314.0
TLS3_k127_932021_2 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000000000000000000000127 162.0
TLS3_k127_932021_3 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000009978 123.0
TLS3_k127_932141_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 1.463e-319 997.0
TLS3_k127_932141_1 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 337.0
TLS3_k127_932141_2 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 309.0
TLS3_k127_932141_3 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 310.0
TLS3_k127_932141_4 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000002104 197.0
TLS3_k127_932141_5 Phospholipid methyltransferase - - - 0.00000000000000000000000000000008456 132.0
TLS3_k127_932141_6 - - - - 0.0000000000000133 82.0
TLS3_k127_932141_7 ligase activity K01469,K01473 - 3.5.2.14,3.5.2.9 0.00001226 58.0
TLS3_k127_934547_0 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 6.12e-264 817.0
TLS3_k127_934547_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 551.0
TLS3_k127_934547_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 350.0
TLS3_k127_934547_3 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000001939 246.0
TLS3_k127_934547_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000009887 233.0
TLS3_k127_934547_5 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000008797 184.0
TLS3_k127_934547_6 - - - - 0.000000000000000000000000000000000000000000005278 169.0
TLS3_k127_940126_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 450.0
TLS3_k127_940126_1 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 351.0
TLS3_k127_940126_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 294.0
TLS3_k127_940126_3 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004473 265.0
TLS3_k127_940126_4 Domain of unknown function (DUF3329) K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000001938 213.0
TLS3_k127_943126_0 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 578.0
TLS3_k127_943126_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 320.0
TLS3_k127_943126_2 Belongs to the UPF0307 family K09889 - - 0.0000000000000000000000000000000000000000205 158.0
TLS3_k127_948342_0 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 424.0
TLS3_k127_948342_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000002018 134.0
TLS3_k127_948342_2 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.000000000000000000001167 96.0
TLS3_k127_951198_0 Acyl-CoA dehydrogenase, C-terminal domain K00253 - 1.3.8.4 8.987e-213 667.0
TLS3_k127_951198_1 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000000000000002332 186.0
TLS3_k127_951198_2 Lysine exporter protein (LYSE YGGA) - - - 0.0000000000000000000000000000000002684 136.0
TLS3_k127_951198_3 ASCH - - - 0.000000000000000000000000000165 128.0
TLS3_k127_951198_4 acetyltransferase - - - 0.00000000000000000000000006759 120.0
TLS3_k127_951198_5 - - - - 0.000000000000005618 82.0
TLS3_k127_951198_6 Thioesterase superfamily - - - 0.0002559 44.0
TLS3_k127_954841_0 efflux pump K18138 - - 1.534e-199 630.0
TLS3_k127_954841_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 356.0
TLS3_k127_955860_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006095 463.0
TLS3_k127_955860_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000006729 244.0
TLS3_k127_955860_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000004877 228.0
TLS3_k127_955860_3 Riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000003464 195.0
TLS3_k127_964274_0 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009077 375.0
TLS3_k127_964274_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 314.0
TLS3_k127_964274_2 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000007494 220.0
TLS3_k127_964274_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000002084 93.0
TLS3_k127_965463_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1127.0
TLS3_k127_965463_1 Methylmalonyl-CoA mutase K01848 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 5.4.99.2 1.516e-227 717.0
TLS3_k127_965463_10 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.000000000000000000000000000000004507 134.0
TLS3_k127_965463_11 - - - - 0.00005972 45.0
TLS3_k127_965463_2 LysR substrate binding domain K13634 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 381.0
TLS3_k127_965463_3 semialdehyde reductase K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 368.0
TLS3_k127_965463_4 esterase K01432 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 325.0
TLS3_k127_965463_5 Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 317.0
TLS3_k127_965463_6 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 290.0
TLS3_k127_965463_7 Electron transfer DM13 - - - 0.00000000000000000000000000000000000000000000000000000000002517 209.0
TLS3_k127_965463_8 B12 binding domain K01849 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0036094,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901363,GO:1901564 5.4.99.2 0.00000000000000000000000000000000000000000000001594 178.0
TLS3_k127_965463_9 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000009673 167.0
TLS3_k127_97127_0 Aldo/keto reductase family K00011 - 1.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 327.0
TLS3_k127_97127_1 PepSY-associated TM region - - - 0.000000000000000000000000000000000000000003152 169.0
TLS3_k127_97127_2 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.0000000000000000000000000005049 122.0
TLS3_k127_97127_3 Protein of unknown function (DUF3072) - - - 0.0000000000001675 72.0
TLS3_k127_971529_0 PFAM Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002225 276.0
TLS3_k127_971529_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000000000000000000000000000000000000000000000000000000000000048 217.0
TLS3_k127_971529_2 - - - - 0.000002709 52.0
TLS3_k127_973776_0 3-oxoacid CoA-transferase, A subunit K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 384.0
TLS3_k127_973776_1 transferase K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 353.0
TLS3_k127_973776_2 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000003887 143.0
TLS3_k127_973776_3 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.0000000000007919 71.0
TLS3_k127_976693_0 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 603.0
TLS3_k127_976693_1 Activates fatty acids by binding to coenzyme A K00666,K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 399.0
TLS3_k127_976693_2 acyl-CoA dehydrogenase - - - 0.0000000000000000000000001621 109.0
TLS3_k127_980298_0 alcohol dehydrogenase K00043,K13954 - 1.1.1.1,1.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 475.0
TLS3_k127_980298_1 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000007517 66.0
TLS3_k127_98866_0 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005436 275.0
TLS3_k127_98866_1 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000003357 176.0
TLS3_k127_98866_2 membrane - - - 0.000000000007872 72.0
TLS3_k127_99427_0 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 301.0
TLS3_k127_99427_1 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000000000000000000000001823 173.0
TLS3_k127_99427_2 Protein of unknown function (DUF2459) - - - 0.000000000000000000000000000000000000000000007259 175.0
TLS3_k127_99427_3 G8 - - - 0.00000000000000000000000000000000000000003227 166.0
TLS3_k127_998645_0 ABC transporter C-terminal domain K06158 - - 2.033e-202 641.0