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Overview

ID MAG04054
Name TLS3_bin.37
Sample SMP0105
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Rhodocyclaceae
Genus Fen-999
Species
Assembly information
Completeness (%) 73.56
Contamination (%) 3.86
GC content (%) 64.0
N50 (bp) 6,557
Genome size (bp) 2,374,060

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2557

Gene name Description KEGG GOs EC E-value Score Sequence
TLS3_k127_1007300_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 9.952e-298 928.0
TLS3_k127_1007300_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 6.331e-250 781.0
TLS3_k127_1007300_2 Ferredoxin - - - 0.000000000000000000000000000000000002327 143.0
TLS3_k127_1007300_3 Rop-like - - - 0.00000000000000005637 81.0
TLS3_k127_1019259_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0 1100.0
TLS3_k127_1019259_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 606.0
TLS3_k127_1019259_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000163 238.0
TLS3_k127_1019259_3 Belongs to the glycosyl hydrolase 57 family K22451 - 2.4.1.25 0.00000000000000000000000000000001718 132.0
TLS3_k127_1021460_0 carbonic anhydrase K01674 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 398.0
TLS3_k127_1021460_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 335.0
TLS3_k127_1021460_2 A G-specific K03575 - - 0.0000000000000000000000000000000000000006547 153.0
TLS3_k127_1044022_0 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 569.0
TLS3_k127_1044022_1 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009972 407.0
TLS3_k127_1044022_2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 376.0
TLS3_k127_1044022_3 COG0079 Histidinol-phosphate aromatic aminotransferase and cobyric acid decarboxylase K02225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 327.0
TLS3_k127_1044022_4 Phasin protein - - - 0.00000000000000000000000000000000000000000000000000000001035 203.0
TLS3_k127_1048353_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.347e-225 702.0
TLS3_k127_1048353_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 584.0
TLS3_k127_1048353_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003823 273.0
TLS3_k127_1048353_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000000000000000313 206.0
TLS3_k127_1048353_4 Ribosomal protein L35 K02916 - - 0.0000000000000000000002097 99.0
TLS3_k127_1048970_0 PFAM Beta-ketoacyl synthase, N-terminal - - - 0.0 1476.0
TLS3_k127_1048970_1 Beta-ketoacyl synthase, N-terminal domain - - - 0.0 1420.0
TLS3_k127_1048970_10 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 333.0
TLS3_k127_1048970_11 synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 340.0
TLS3_k127_1048970_12 stress-induced mitochondrial fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 291.0
TLS3_k127_1048970_13 Catalyzes the synthesis of activated sulfate K00860,K00958 - 2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000002745 263.0
TLS3_k127_1048970_14 regulator - - - 0.00000000000000000000000000000000000000000000000000000000002761 207.0
TLS3_k127_1048970_15 4'-phosphopantetheinyl transferase superfamily K00997,K06133 - 2.7.8.7 0.00000000000000000000000000000000000000000000593 171.0
TLS3_k127_1048970_16 Domain of unknown function (DUF697) - - - 0.00000000000000000000000000000000000005194 148.0
TLS3_k127_1048970_17 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000000000000000000004421 139.0
TLS3_k127_1048970_18 HNH nucleases K07451 - - 0.00000000000000000000000000000001338 136.0
TLS3_k127_1048970_19 protein domain associated with - - - 0.000000000000000000000000000000258 131.0
TLS3_k127_1048970_2 Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - 0.0 1299.0
TLS3_k127_1048970_20 Bacterial extracellular solute-binding proteins, family 3 K02030 - - 0.000000000000000000004673 102.0
TLS3_k127_1048970_21 Phosphopantetheine attachment site - - - 0.00000000000000000758 87.0
TLS3_k127_1048970_22 - - - - 0.00000000004853 74.0
TLS3_k127_1048970_23 Branched-chain amino acid ABC transporter, substrate-binding protein K01999 - - 0.000000001895 70.0
TLS3_k127_1048970_24 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000002678 61.0
TLS3_k127_1048970_25 - - - - 0.00000007305 55.0
TLS3_k127_1048970_26 protein conserved in bacteria K19166 - - 0.00004129 48.0
TLS3_k127_1048970_3 acyl transferase domain K16128 - - 0.0 1288.0
TLS3_k127_1048970_4 PFAM short-chain dehydrogenase reductase SDR - - - 6.907e-311 1004.0
TLS3_k127_1048970_5 synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000746 599.0
TLS3_k127_1048970_6 PFAM Acyl-CoA dehydrogenase, C-terminal domain K06445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 462.0
TLS3_k127_1048970_7 phosphopantetheine binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 432.0
TLS3_k127_1048970_8 Cyclic peptide transporter K06160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 438.0
TLS3_k127_1048970_9 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 400.0
TLS3_k127_1053637_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 499.0
TLS3_k127_1053637_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 427.0
TLS3_k127_1053637_2 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004385 287.0
TLS3_k127_1053637_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001957 284.0
TLS3_k127_1053637_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002878 251.0
TLS3_k127_1053637_5 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000001689 163.0
TLS3_k127_10558_0 Respiratory-chain NADH dehydrogenase 51 Kd subunit K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 516.0
TLS3_k127_10558_1 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000003325 209.0
TLS3_k127_1086385_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 569.0
TLS3_k127_1086385_1 - - - - 0.000000000000008873 79.0
TLS3_k127_110546_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 300.0
TLS3_k127_110546_1 Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000002811 248.0
TLS3_k127_110546_2 COG1538 Outer membrane protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007317 251.0
TLS3_k127_110546_3 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000000000003865 142.0
TLS3_k127_110546_4 Tfp pilus assembly protein FimV - - - 0.00000000000000002604 96.0
TLS3_k127_1113360_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 6.792e-254 797.0
TLS3_k127_1113360_1 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008747 510.0
TLS3_k127_1113360_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006907 474.0
TLS3_k127_1113360_3 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 447.0
TLS3_k127_1113360_4 enzyme of heme biosynthesis K02498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 331.0
TLS3_k127_1113360_5 HemX, putative uroporphyrinogen-III C-methyltransferase K02496 - 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 319.0
TLS3_k127_1113360_6 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001997 282.0
TLS3_k127_1141211_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 4.548e-298 923.0
TLS3_k127_1141211_1 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007897 316.0
TLS3_k127_1141211_2 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005056 268.0
TLS3_k127_1141211_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000001987 134.0
TLS3_k127_1141211_4 PFAM regulatory protein LuxR - - - 0.0000000000444 73.0
TLS3_k127_1153826_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1356.0
TLS3_k127_1153826_1 Formate dehydrogenase N, transmembrane K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000495 539.0
TLS3_k127_1153826_2 Prokaryotic cytochrome b561 K00127 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005122 349.0
TLS3_k127_1153826_3 Necessary for formate dehydrogenase activity K02380 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 293.0
TLS3_k127_1153826_4 molybdopterin oxidoreductase fe4s4 region K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000001591 258.0
TLS3_k127_1153826_5 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.000000000001662 79.0
TLS3_k127_1179862_0 ABC transporter K06158 - - 4.389e-317 975.0
TLS3_k127_1179862_1 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 2.869e-289 898.0
TLS3_k127_1179862_2 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000255 285.0
TLS3_k127_1179862_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004615 271.0
TLS3_k127_1179862_4 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000009134 274.0
TLS3_k127_1179862_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000002054 258.0
TLS3_k127_1179862_6 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000001119 215.0
TLS3_k127_1206556_0 Helix-turn-helix type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 369.0
TLS3_k127_1206556_1 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 360.0
TLS3_k127_1206556_10 Protein of unknown function (DUF465) - - - 0.00000000000000002249 84.0
TLS3_k127_1206556_11 Chemoreceptor zinc-binding domain - - - 0.00000000000002811 83.0
TLS3_k127_1206556_12 Protein of unknown function (DUF3617) - - - 0.0000002364 63.0
TLS3_k127_1206556_2 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 335.0
TLS3_k127_1206556_3 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001307 252.0
TLS3_k127_1206556_4 Cobalt transport protein K02008 - - 0.000000000000000000000000000000000000000000000000000000000000142 222.0
TLS3_k127_1206556_5 Pfam Pyridoxamine 5'-phosphate K07226 - - 0.00000000000000000000000000000000000000003078 160.0
TLS3_k127_1206556_6 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.000000000000000000000000000000000000008264 159.0
TLS3_k127_1206556_7 - - - - 0.000000000000000000000000000001388 127.0
TLS3_k127_1206556_8 Ni,Fe-hydrogenase I large subunit - - - 0.0000000000000000000000001657 116.0
TLS3_k127_1206556_9 PFAM PhnA protein K06193 - - 0.000000000000000000008741 91.0
TLS3_k127_1214667_0 Glucose sorbosone K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 578.0
TLS3_k127_1214667_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001204 269.0
TLS3_k127_1214667_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000001696 222.0
TLS3_k127_1214667_4 Dodecin K09165 - - 0.0000000000000000000000001509 107.0
TLS3_k127_1234467_0 DNA topoisomerase III K03169 - 5.99.1.2 4.338e-254 796.0
TLS3_k127_1234467_1 - - - - 0.0000000000000000000002447 105.0
TLS3_k127_1234467_2 Lysin motif - - - 0.000000000000000008223 86.0
TLS3_k127_1240218_0 Periplasmic binding protein K01999 - - 2.099e-255 792.0
TLS3_k127_1240218_1 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 482.0
TLS3_k127_1240218_2 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002422 292.0
TLS3_k127_1240218_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000001953 126.0
TLS3_k127_1291013_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1054.0
TLS3_k127_1291013_1 COG1960 Acyl-CoA dehydrogenases K20035 - - 4.509e-268 836.0
TLS3_k127_1291013_2 Exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 1.636e-210 666.0
TLS3_k127_1291013_3 Electron transfer flavoprotein alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 466.0
TLS3_k127_1291013_4 Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 415.0
TLS3_k127_1291013_5 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007623 380.0
TLS3_k127_1291013_6 Cobalt uptake substrate-specific transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000001653 239.0
TLS3_k127_1291013_7 'signal transduction protein - - - 0.00000000000000000000000000000000000000000000000000000000000008129 225.0
TLS3_k127_1291013_8 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000417 223.0
TLS3_k127_1291013_9 Protein of unknown function (DUF1631) - - - 0.000004593 55.0
TLS3_k127_1317336_0 DnaJ molecular chaperone homology domain K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 456.0
TLS3_k127_1317336_1 PFAM alpha beta hydrolase fold K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 421.0
TLS3_k127_1317336_2 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 328.0
TLS3_k127_1317336_3 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 301.0
TLS3_k127_1317336_4 cell septum assembly - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 304.0
TLS3_k127_1317336_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000429 261.0
TLS3_k127_1317336_6 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000004684 233.0
TLS3_k127_1317336_7 MerR HTH family regulatory protein K18997 - - 0.0000000000000000000000000000003863 124.0
TLS3_k127_1317336_8 Belongs to the ompA family K03286 - - 0.0000000000000000000000000002728 115.0
TLS3_k127_1317336_9 BON domain - - - 0.00000000000000000000002578 104.0
TLS3_k127_133874_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.0 1103.0
TLS3_k127_133874_1 Malic enzyme, NAD binding domain K00027,K00029 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40 0.0 1030.0
TLS3_k127_133874_2 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 284.0
TLS3_k127_133874_3 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000002489 153.0
TLS3_k127_1341900_0 Hsp33 protein K04083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 325.0
TLS3_k127_1341900_1 PFAM Spermine synthase K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 311.0
TLS3_k127_1341900_2 Belongs to the ArsC family K00537 - 1.20.4.1 0.0000000000000009667 78.0
TLS3_k127_1422469_0 MASE1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 562.0
TLS3_k127_1422469_1 PFAM regulatory protein LuxR K13041 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007439 261.0
TLS3_k127_1422469_2 Na H antiporter, MnhB K05566 - - 0.00000000000000000000000000000000000000000000000000000000000000008232 228.0
TLS3_k127_1422469_3 Na H antiporter, MnhB K05566 - - 0.0000000000000000000000000000000000000000000000000000000000000002203 231.0
TLS3_k127_1422469_4 COG1863 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000000000000003482 225.0
TLS3_k127_1422469_5 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000009297 215.0
TLS3_k127_1422469_6 COG1006 Multisubunit Na H antiporter, MnhC subunit K05567 - - 0.0000000000000000000000000000000000000000006458 167.0
TLS3_k127_1422469_7 monovalent cation:proton antiporter activity K05571 - - 0.000000000000000000000000000000159 132.0
TLS3_k127_1422469_8 Proton-conducting membrane transporter - - - 0.000000000000000000000000000002316 129.0
TLS3_k127_1422469_9 Multiple resistance and pH regulation protein F K05570 - - 0.0000000000000000000000000009545 122.0
TLS3_k127_1478020_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 1.77e-241 758.0
TLS3_k127_1544825_0 B12 binding domain - - - 1.903e-286 887.0
TLS3_k127_1544825_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 402.0
TLS3_k127_1544825_2 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000006005 254.0
TLS3_k127_1544825_3 HPP family K07168 - - 0.00000000000000000000000000000000000000005253 162.0
TLS3_k127_1544825_4 HHE cation binding domain K07216 - - 0.0000000000000000000000000000000000005405 147.0
TLS3_k127_1544825_5 AAA ATPase domain - - - 0.000003873 57.0
TLS3_k127_1570539_0 Histidine kinase - - - 1.355e-298 966.0
TLS3_k127_1570539_1 Aldehyde dehydrogenase family K00130,K09472,K12254 - 1.2.1.54,1.2.1.8,1.2.1.99 4.749e-238 745.0
TLS3_k127_1570539_10 cheY-homologous receiver domain K03413 - - 0.000000000008041 66.0
TLS3_k127_1570539_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 6.835e-235 736.0
TLS3_k127_1570539_3 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.451e-223 702.0
TLS3_k127_1570539_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 621.0
TLS3_k127_1570539_5 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 572.0
TLS3_k127_1570539_6 glutamine synthetase K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009721 524.0
TLS3_k127_1570539_7 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 489.0
TLS3_k127_1570539_8 long-chain fatty acid transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000007228 227.0
TLS3_k127_1570539_9 - - - - 0.000000000000000000000000000000000000000000000004104 184.0
TLS3_k127_1651013_0 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 332.0
TLS3_k127_1651013_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002296 288.0
TLS3_k127_1651013_2 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000006237 201.0
TLS3_k127_1651013_3 - - - - 0.00000000000000000000000000000000006528 138.0
TLS3_k127_1651013_4 AMP-binding enzyme K01912 - 6.2.1.30 0.000000000197 61.0
TLS3_k127_1740377_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 4.778e-254 793.0
TLS3_k127_1740377_1 argininosuccinate lyase K01755 - 4.3.2.1 1.116e-240 749.0
TLS3_k127_1740377_2 alginate biosynthesis protein AlgZ FimS K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 306.0
TLS3_k127_1740377_3 Alginate biosynthesis regulatory protein AlgR K08083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005009 279.0
TLS3_k127_1740377_4 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000002335 203.0
TLS3_k127_1745035_0 Belongs to the thiolase family K00626 - 2.3.1.9 6.552e-195 611.0
TLS3_k127_1745035_1 chemotaxis K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 377.0
TLS3_k127_1745035_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 341.0
TLS3_k127_1745035_3 diol metabolic process K01724 - 4.2.1.96 0.00000000000000000000000000000483 123.0
TLS3_k127_1745035_4 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.00000000000000138 76.0
TLS3_k127_174515_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 2.245e-235 743.0
TLS3_k127_174515_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 539.0
TLS3_k127_174515_2 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 457.0
TLS3_k127_174515_3 protein, hemolysin III K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 299.0
TLS3_k127_174515_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family K00569 - 2.1.1.67 0.00000000000000000000000000000000000000000000000000000000000000000000000004261 256.0
TLS3_k127_174515_5 - - - - 0.000000000000000000505 87.0
TLS3_k127_174515_6 Protein of unknown function (DUF3096) - - - 0.000005493 53.0
TLS3_k127_1745345_0 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0 1069.0
TLS3_k127_1745345_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 612.0
TLS3_k127_1745345_10 Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000000000003531 134.0
TLS3_k127_1745345_2 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 562.0
TLS3_k127_1745345_3 Ubiquinone biosynthesis hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 482.0
TLS3_k127_1745345_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 284.0
TLS3_k127_1745345_5 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 286.0
TLS3_k127_1745345_6 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001096 273.0
TLS3_k127_1745345_7 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000000000000000000000004034 227.0
TLS3_k127_1745345_8 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000000000002262 205.0
TLS3_k127_1745345_9 TonB C terminal K03646 - - 0.00000000000000000000000000000000000000000000000001823 191.0
TLS3_k127_1750285_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008838 542.0
TLS3_k127_1750285_1 TonB C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006151 266.0
TLS3_k127_1750285_2 UbiH UbiF VisC COQ6 family K03185 - - 0.0000000000000000000000000000000000000000000000003747 177.0
TLS3_k127_1750285_3 PFAM RES domain - - - 0.000000000000000000000000000000000000000000005176 175.0
TLS3_k127_1750285_4 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000005587 151.0
TLS3_k127_1750285_5 Belongs to the transcriptional regulatory Fis family K03557 - - 0.00000000000000000000000004454 119.0
TLS3_k127_1750285_6 Protein of unknown function (DUF2384) - - - 0.0000000000000000000006033 102.0
TLS3_k127_176717_0 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 599.0
TLS3_k127_176717_1 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 518.0
TLS3_k127_176717_10 PFAM SlyX family protein K03745 - - 0.0000000000000004262 83.0
TLS3_k127_176717_11 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000001772 68.0
TLS3_k127_176717_2 Thioredoxin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 344.0
TLS3_k127_176717_3 low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000003668 246.0
TLS3_k127_176717_4 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000002269 235.0
TLS3_k127_176717_5 PFAM Endonuclease exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000002564 221.0
TLS3_k127_176717_6 Thioredoxin domain - - - 0.0000000000000000000000000000000002247 133.0
TLS3_k127_176717_7 transcriptional regulators K03892 - - 0.000000000000000000000000000000001048 133.0
TLS3_k127_176717_8 - - - - 0.00000000000000000000000000005311 118.0
TLS3_k127_176717_9 - - - - 0.000000000000000006068 88.0
TLS3_k127_1772172_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 7.723e-306 942.0
TLS3_k127_1772172_1 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 2.447e-204 640.0
TLS3_k127_1772172_2 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 381.0
TLS3_k127_1772172_3 Hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 358.0
TLS3_k127_1772172_4 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000000000000000000000000006336 194.0
TLS3_k127_1772172_5 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000000003576 164.0
TLS3_k127_1772172_6 [NiFe]-hydrogenase assembly, chaperone, HybE - - - 0.00000000000000000000000000000000008049 141.0
TLS3_k127_1772172_7 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000000000000008436 106.0
TLS3_k127_1772172_8 HupF/HypC family K04653 - - 0.000000000000000003196 93.0
TLS3_k127_1772172_9 hydrogenase expression formation protein HypE K04655 - - 0.0000000001615 65.0
TLS3_k127_1775294_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.57e-270 843.0
TLS3_k127_1775294_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 1.728e-234 730.0
TLS3_k127_1775294_10 HAD-superfamily hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 303.0
TLS3_k127_1775294_11 Uroporphyrin-III C tetrapyrrole K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 294.0
TLS3_k127_1775294_12 Sigma E regulatory protein, MucB RseB K03598 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002483 284.0
TLS3_k127_1775294_13 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001171 264.0
TLS3_k127_1775294_14 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000005815 137.0
TLS3_k127_1775294_15 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000000000002164 118.0
TLS3_k127_1775294_16 Glutaredoxin-like domain (DUF836) - - - 0.000000000000000000000000004501 111.0
TLS3_k127_1775294_17 metal-binding, possibly nucleic acid-binding protein K07040 - - 0.00000000000000000000000003128 114.0
TLS3_k127_1775294_18 PFAM Anti sigma-E protein RseA K03597 - - 0.0000000001486 69.0
TLS3_k127_1775294_19 Positive regulator of sigma(E), RseC/MucC - - - 0.00000001188 64.0
TLS3_k127_1775294_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 4.071e-213 677.0
TLS3_k127_1775294_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 484.0
TLS3_k127_1775294_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 479.0
TLS3_k127_1775294_5 signal peptide peptidase K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 438.0
TLS3_k127_1775294_6 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 433.0
TLS3_k127_1775294_7 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 426.0
TLS3_k127_1775294_8 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007391 359.0
TLS3_k127_1775294_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007771 324.0
TLS3_k127_1791731_0 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 376.0
TLS3_k127_1791731_1 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 331.0
TLS3_k127_1791731_2 ABC transporter permease K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003986 241.0
TLS3_k127_1842207_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 4.976e-241 751.0
TLS3_k127_1842207_1 Ferrous iron transport protein B K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 438.0
TLS3_k127_1842207_2 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000000000000000001115 166.0
TLS3_k127_1842207_3 Protein of unknown function (DUF1161) - - - 0.00000000000000001406 84.0
TLS3_k127_184221_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 3.471e-320 992.0
TLS3_k127_184221_1 Flagellar biosynthesis regulator FlhF K02404 - - 0.00000000000000000000000000000000000000000000000000000000000000007333 232.0
TLS3_k127_1862555_0 ABC-type Fe3 transport system, permease component K02011 - - 3.291e-225 711.0
TLS3_k127_1862555_1 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 513.0
TLS3_k127_1862555_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 508.0
TLS3_k127_1862555_3 NLP P60 protein - - - 0.000000000000000000000000000000000000000000000000002018 186.0
TLS3_k127_19011_0 SIR2-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 384.0
TLS3_k127_19011_1 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) K05951 - 2.4.2.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 378.0
TLS3_k127_19011_3 - - - - 0.0000000000000000000007749 97.0
TLS3_k127_191483_0 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 3.187e-213 664.0
TLS3_k127_191483_1 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 545.0
TLS3_k127_191483_2 Dipeptidyl-peptidase 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 472.0
TLS3_k127_191483_3 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000000000000000000000006069 231.0
TLS3_k127_1937911_0 Belongs to the ClpA ClpB family K03694 - - 2.189e-314 969.0
TLS3_k127_1941285_0 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005915 529.0
TLS3_k127_1941285_1 Protein of unknown function (DUF2863) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 462.0
TLS3_k127_1941285_2 Tex-like protein N-terminal domain K06959 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 345.0
TLS3_k127_1941285_3 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000879 233.0
TLS3_k127_1941285_4 Protein of unknown function DUF47 K07220 - - 0.0000006148 62.0
TLS3_k127_1943164_0 transposase IS116 IS110 IS902 family K07486 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 370.0
TLS3_k127_1943164_1 Transposase, Mutator family K07493 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 353.0
TLS3_k127_1943164_2 Bacterial dnaA protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007282 273.0
TLS3_k127_1943164_3 DNA replication protein - - - 0.0000000000000000000004433 111.0
TLS3_k127_1943164_4 COG4584 Transposase and inactivated derivatives - - - 0.0000000000004959 69.0
TLS3_k127_1943164_5 Integrase core domain - - - 0.000000009582 61.0
TLS3_k127_1944034_0 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 403.0
TLS3_k127_1944034_1 COG0564 Pseudouridylate synthases, 23S RNA-specific K06175 - 5.4.99.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 327.0
TLS3_k127_1944034_2 cytochrome complex assembly K02200 - - 0.0000000000000000000009853 101.0
TLS3_k127_1944034_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000971 95.0
TLS3_k127_1944034_4 Glycine zipper 2TM domain - - - 0.000000000005747 72.0
TLS3_k127_1982012_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 2.763e-234 736.0
TLS3_k127_1982012_1 Protein of unknown function (DUF3301) - - - 0.00000000000000000000000007999 110.0
TLS3_k127_1982012_2 - - - - 0.0000000000000005846 79.0
TLS3_k127_19832_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 6.685e-307 944.0
TLS3_k127_19832_1 carboxylase K01965 - 6.4.1.3 4.348e-303 939.0
TLS3_k127_19832_2 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.000000000000000000000000000000000000000000001831 168.0
TLS3_k127_1997568_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 1.135e-223 700.0
TLS3_k127_1997568_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 420.0
TLS3_k127_1997568_2 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 392.0
TLS3_k127_1997568_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 337.0
TLS3_k127_1997568_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000008771 245.0
TLS3_k127_2008102_0 Belongs to the glycosyl hydrolase 43 family K01218,K19551 - 3.2.1.78,4.2.2.10,4.2.2.2 8.803e-202 636.0
TLS3_k127_2008102_1 ADP-ribosyl- dinitrogen reductase hydrolase K05521 - 3.2.2.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 396.0
TLS3_k127_2008102_2 NmrA-like family K19267 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000001358 264.0
TLS3_k127_2008102_3 SIR2-like domain - - - 0.0000000000000000000000000000000000000000000000000001301 188.0
TLS3_k127_2008102_4 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000004823 183.0
TLS3_k127_2008102_5 PFAM Hemerythrin HHE cation binding domain protein - - - 0.000000000000000000000000000000000001631 148.0
TLS3_k127_201590_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007946 599.0
TLS3_k127_201590_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 326.0
TLS3_k127_201590_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000196 152.0
TLS3_k127_201965_0 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 555.0
TLS3_k127_201965_1 Drug resistance transporter Bcr CflA subfamily K07552 - - 0.0000000000000000000000000000000000000000000000000000000003101 208.0
TLS3_k127_201965_2 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000001626 161.0
TLS3_k127_201965_3 Transcriptional regulator - - - 0.0000000000000000000003579 96.0
TLS3_k127_2019981_0 Radical SAM K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 591.0
TLS3_k127_2019981_1 Transport of potassium into the cell K03549 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 536.0
TLS3_k127_202828_0 Domain of unknown function DUF21 K03699 - - 2.567e-207 653.0
TLS3_k127_202828_1 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 533.0
TLS3_k127_202828_2 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005125 469.0
TLS3_k127_202828_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009687 413.0
TLS3_k127_202828_4 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000002809 195.0
TLS3_k127_202828_5 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000002571 138.0
TLS3_k127_202828_6 PFAM Cytochrome c, class I K08738 - - 0.000000000000000000000006132 108.0
TLS3_k127_2104816_0 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 518.0
TLS3_k127_2104816_1 Peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 393.0
TLS3_k127_2104816_2 Domain of unknown function (DUF4398) - - - 0.000000000000000000000000000001512 126.0
TLS3_k127_2109593_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 469.0
TLS3_k127_2109593_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 379.0
TLS3_k127_2109593_2 cytochrome - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001418 267.0
TLS3_k127_2109593_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000001903 231.0
TLS3_k127_2109593_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000007208 213.0
TLS3_k127_2109593_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000001561 64.0
TLS3_k127_2131686_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.089e-219 689.0
TLS3_k127_2131686_1 Endonuclease Exonuclease Phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 525.0
TLS3_k127_2131686_10 Uncharacterized ACR, COG1993 - - - 0.000000000000000000000000000000000000000000000001418 175.0
TLS3_k127_2131686_11 - - - - 0.0000000000000000000000000000000000000000187 157.0
TLS3_k127_2131686_12 Ethylbenzene dehydrogenase - - - 0.000000000000000000000000000000000000003659 152.0
TLS3_k127_2131686_13 Protein of unknown function (DUF2789) - - - 0.0000000000000000006732 100.0
TLS3_k127_2131686_2 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009257 511.0
TLS3_k127_2131686_3 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 489.0
TLS3_k127_2131686_4 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 319.0
TLS3_k127_2131686_5 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000006998 228.0
TLS3_k127_2131686_6 Belongs to the pseudouridine synthase RsuA family K06183 - 5.4.99.19 0.000000000000000000000000000000000000000000000000000000000008797 209.0
TLS3_k127_2131686_7 Secreted repeat of unknown function - - - 0.0000000000000000000000000000000000000000000000000000000002247 205.0
TLS3_k127_2131686_8 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000009399 220.0
TLS3_k127_2131686_9 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000000000000000000000000000000003489 192.0
TLS3_k127_214019_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 5.96e-237 740.0
TLS3_k127_214019_1 exodeoxyribonuclease iii K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 424.0
TLS3_k127_214019_2 Bacterial protein of unknown function (DUF883) - - - 0.000000000000000000000000000000008731 130.0
TLS3_k127_214019_3 NlpC/P60 family - - - 0.00000000000000000000000007692 109.0
TLS3_k127_214019_4 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000000000000001388 107.0
TLS3_k127_214019_5 YqjK-like protein - - - 0.0000000001107 68.0
TLS3_k127_214019_6 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000002709 52.0
TLS3_k127_21677_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - 0.0 1125.0
TLS3_k127_21677_1 SMART beta-lactamase domain protein K01120 - 3.1.4.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002939 272.0
TLS3_k127_21677_2 phosphohistidine phosphatase, SixA K08296 - - 0.000000000000000000000000000000000000000000000001052 185.0
TLS3_k127_21677_3 Pilin (bacterial filament) K02650 - - 0.0000000000000000000000000000000008 135.0
TLS3_k127_21677_4 Pilin (bacterial filament) K02650 - - 0.0000000000000000000000000000001179 130.0
TLS3_k127_21677_5 CHAD domain K01768 - 4.6.1.1 0.00000000000000006903 85.0
TLS3_k127_2175338_0 AAA domain K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 611.0
TLS3_k127_2175338_1 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 513.0
TLS3_k127_2175338_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 353.0
TLS3_k127_2175338_3 - - - - 0.00000000000000000000000000005393 122.0
TLS3_k127_2175338_4 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.000000000000000000000001941 102.0
TLS3_k127_2194106_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 1.129e-242 758.0
TLS3_k127_2194106_1 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 569.0
TLS3_k127_2194106_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 521.0
TLS3_k127_2194106_3 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 349.0
TLS3_k127_2194106_4 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000006441 259.0
TLS3_k127_2194106_5 D-ala D-ala ligase N-terminus K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000001443 201.0
TLS3_k127_2208385_0 UDP binding domain - - - 5.402e-231 720.0
TLS3_k127_2208385_1 COG1450 Type II secretory pathway, component PulD K02453 - - 1.243e-222 712.0
TLS3_k127_2208385_10 General secretion pathway protein F K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 470.0
TLS3_k127_2208385_11 homoserine dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 440.0
TLS3_k127_2208385_12 Glucose-1-phosphate cytidylyltransferase K00978,K15669 - 2.7.7.33,2.7.7.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 419.0
TLS3_k127_2208385_13 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 415.0
TLS3_k127_2208385_14 Polysaccharide chain length determinant protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 422.0
TLS3_k127_2208385_15 serine acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 398.0
TLS3_k127_2208385_16 SMART AAA ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 386.0
TLS3_k127_2208385_17 Domain of unknown function (DUF3473) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 362.0
TLS3_k127_2208385_18 Putative collagen-binding domain of a collagenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009763 367.0
TLS3_k127_2208385_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006644 327.0
TLS3_k127_2208385_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 8.551e-218 680.0
TLS3_k127_2208385_20 COG1596 Periplasmic protein involved in polysaccharide export K01991 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 317.0
TLS3_k127_2208385_21 AAA domain K08252,K16692 - 2.7.10.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 309.0
TLS3_k127_2208385_22 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 293.0
TLS3_k127_2208385_23 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002156 274.0
TLS3_k127_2208385_24 Type II secretion system (T2SS), protein K K02460 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002387 270.0
TLS3_k127_2208385_25 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005231 258.0
TLS3_k127_2208385_26 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005499 269.0
TLS3_k127_2208385_27 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001041 251.0
TLS3_k127_2208385_28 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000007031 233.0
TLS3_k127_2208385_29 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000002229 239.0
TLS3_k127_2208385_3 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 5.345e-200 634.0
TLS3_k127_2208385_30 general secretion pathway protein G K02456 - - 0.000000000000000000000000000000000000000000000000000000000000008129 221.0
TLS3_k127_2208385_31 Rrf2 family transcriptional regulator, iron-sulfur cluster assembly K13643 - - 0.00000000000000000000000000000000000000000000000000000000000005004 218.0
TLS3_k127_2208385_32 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000003733 223.0
TLS3_k127_2208385_33 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K00067,K01790 - 1.1.1.133,5.1.3.13 0.000000000000000000000000000000000000000000000000000000000003374 213.0
TLS3_k127_2208385_34 polysaccharide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000008956 228.0
TLS3_k127_2208385_35 TIGRFAM PEP-CTERM system associated protein - - - 0.00000000000000000000000000000000000000000000000000000000001251 226.0
TLS3_k127_2208385_36 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000002254 220.0
TLS3_k127_2208385_37 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000000009464 187.0
TLS3_k127_2208385_38 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000000000000000000000001302 189.0
TLS3_k127_2208385_39 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000001024 150.0
TLS3_k127_2208385_4 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 584.0
TLS3_k127_2208385_40 Type II secretion system (T2SS), protein N K02463 - - 0.0000000000000000000000000000000002937 142.0
TLS3_k127_2208385_41 Type II secretion system (T2SS), protein I K02458 - - 0.000000000000000000000000000002664 124.0
TLS3_k127_2208385_42 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000008118 124.0
TLS3_k127_2208385_43 Type II secretion system (T2SS), protein J K02459 - - 0.0000000000000000000002243 108.0
TLS3_k127_2208385_44 O-Antigen Polymerase - - - 0.0000000000000000004812 100.0
TLS3_k127_2208385_45 Prokaryotic N-terminal methylation motif K02457 - - 0.000000000000001256 83.0
TLS3_k127_2208385_46 PFAM Di-glucose binding within endoplasmic reticulum - - - 0.0000000000005813 80.0
TLS3_k127_2208385_47 General secretion pathway protein L K02461 - - 0.00000000004132 75.0
TLS3_k127_2208385_48 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0006457,GO:0008150,GO:0009987 - 0.000000003282 57.0
TLS3_k127_2208385_49 Polysaccharide pyruvyl transferase - - - 0.000000007836 68.0
TLS3_k127_2208385_5 Male sterility protein K02473 - 5.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 564.0
TLS3_k127_2208385_50 Aminoglycoside phosphotransferase - - - 0.000001142 61.0
TLS3_k127_2208385_51 Type II secretion system protein C K02452 - - 0.0001112 53.0
TLS3_k127_2208385_6 Male sterility protein K01709 - 4.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 557.0
TLS3_k127_2208385_7 COG2148 Sugar transferases involved in lipopolysaccharide synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 542.0
TLS3_k127_2208385_8 PFAM aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 537.0
TLS3_k127_2208385_9 Cysteine desulfurase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 509.0
TLS3_k127_2236029_0 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002932 268.0
TLS3_k127_2236029_1 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000000000000000000000000000001115 178.0
TLS3_k127_2236029_2 TfoX N-terminal domain - - - 0.000000000000000000000000000000000001016 147.0
TLS3_k127_2236029_3 - - - - 0.000000000000000000000000001431 116.0
TLS3_k127_2236029_4 - - - - 0.0000000000001936 76.0
TLS3_k127_2248024_0 His Kinase A (phosphoacceptor) domain - - - 7.516e-268 834.0
TLS3_k127_2248024_1 indolepyruvate ferredoxin oxidoreductase K04090 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 514.0
TLS3_k127_2248024_2 cheY-homologous receiver domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 416.0
TLS3_k127_2248024_3 5''-nucleotidase K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000002928 162.0
TLS3_k127_225381_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 5.149e-315 974.0
TLS3_k127_225381_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.048e-281 870.0
TLS3_k127_225381_10 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000001266 170.0
TLS3_k127_225381_11 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000000000001247 148.0
TLS3_k127_225381_12 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000001271 73.0
TLS3_k127_225381_13 ATP synthase I chain K02116 - - 0.0000000002711 66.0
TLS3_k127_225381_2 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 1.628e-277 863.0
TLS3_k127_225381_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 453.0
TLS3_k127_225381_4 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 417.0
TLS3_k127_225381_5 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 391.0
TLS3_k127_225381_6 ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 347.0
TLS3_k127_225381_7 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000000000000002283 233.0
TLS3_k127_225381_8 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000000000000000002032 212.0
TLS3_k127_225381_9 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000001406 192.0
TLS3_k127_2272762_0 mechanosensitive K05802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 477.0
TLS3_k127_2272762_1 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004456 319.0
TLS3_k127_2272762_2 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000000000000000000006132 143.0
TLS3_k127_2272762_3 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000000000000004128 110.0
TLS3_k127_2272762_4 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000003588 85.0
TLS3_k127_2308174_0 N-6 DNA methylase K03427 - 2.1.1.72 7.661e-244 758.0
TLS3_k127_2308174_1 This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation K02591 - 1.18.6.1 1.084e-234 729.0
TLS3_k127_2308174_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009935 459.0
TLS3_k127_2308174_3 Dinitrogenase iron-molybdenum cofactor, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 317.0
TLS3_k127_2308174_4 nitrogen fixation K02593 - - 0.000000000000000000000000000000001655 130.0
TLS3_k127_2308174_5 4Fe-4S binding domain - - - 0.00000000000000000000000002955 112.0
TLS3_k127_2311023_0 Butirosin biosynthesis protein H, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 512.0
TLS3_k127_2311023_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 512.0
TLS3_k127_2311023_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 327.0
TLS3_k127_233948_0 von Willebrand factor (vWF) type A domain K02448 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 521.0
TLS3_k127_233948_1 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 467.0
TLS3_k127_233948_2 4Fe-4S dicluster domain K16887 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006262 334.0
TLS3_k127_233948_3 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.000000000000000000000000000000000000000000000000000000000000000000267 240.0
TLS3_k127_233948_4 response regulator receiver K13041 - - 0.0000000000000000000000000000000000000000000000000007354 190.0
TLS3_k127_233948_5 - - - - 0.0000000000000000000000000000000000000000001014 162.0
TLS3_k127_233948_7 Sulfate transporter antisigma-factor antagonist STAS K03321 - - 0.000000000000000000000000000000000000001857 167.0
TLS3_k127_233948_8 CbbQ/NirQ/NorQ C-terminal K04748 - - 0.000000000000001036 78.0
TLS3_k127_2397829_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000004496 221.0
TLS3_k127_2397829_1 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.000000000000000000000000000000000000000000000000000007955 196.0
TLS3_k127_2397829_2 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000005133 116.0
TLS3_k127_2397829_3 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.00000000000000000000001289 105.0
TLS3_k127_2414160_0 4Fe-4S dicluster domain K02573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 425.0
TLS3_k127_2414160_1 TIGRFAM ferredoxin-type protein, NapH MauN family K02574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 421.0
TLS3_k127_2414160_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 376.0
TLS3_k127_2414160_3 cytochrome c-type protein K02569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 309.0
TLS3_k127_2414160_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002018 265.0
TLS3_k127_2414160_5 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB K02568 - - 0.00000000000000000000000000000002607 131.0
TLS3_k127_2414160_6 - - - - 0.00000000000000000000000000000002673 130.0
TLS3_k127_2414160_7 Cytochrome c K08738 - - 0.000000000000000000000001668 108.0
TLS3_k127_24245_0 Protein of unknown function (DUF1631) - - - 0.000000000000000000000000000000000002538 148.0
TLS3_k127_24245_1 Protein of unknown function (DUF3617) - - - 0.0000000000000001375 89.0
TLS3_k127_2439915_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1978.0
TLS3_k127_2439915_1 Part of a membrane complex involved in electron transport K03615 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 401.0
TLS3_k127_2458418_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.0 1567.0
TLS3_k127_2458418_1 Protein of unknown function - - - 0.0 1146.0
TLS3_k127_2458418_10 Domain of unknown function (DUF3369) - - - 0.000000000000000000000000000000000000000000000000000000000003872 226.0
TLS3_k127_2458418_11 Etoposide-induced protein 2.4 (EI24) - - - 0.0000000000000000000000000000000000000175 153.0
TLS3_k127_2458418_12 - - - - 0.00003554 49.0
TLS3_k127_2458418_2 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1045.0
TLS3_k127_2458418_3 glutaminyl-tRNA K01886 - 6.1.1.18 1.128e-267 836.0
TLS3_k127_2458418_4 modulator of DNA gyrase K03568 - - 3.322e-216 680.0
TLS3_k127_2458418_5 Elements of external origin K07494 - - 4.017e-213 664.0
TLS3_k127_2458418_6 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 376.0
TLS3_k127_2458418_7 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 366.0
TLS3_k127_2458418_8 Molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006688 297.0
TLS3_k127_2458418_9 response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001437 233.0
TLS3_k127_247748_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 468.0
TLS3_k127_247748_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006758 326.0
TLS3_k127_2487092_0 UPF0313 protein - - - 0.0 1086.0
TLS3_k127_2487092_1 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 297.0
TLS3_k127_2487092_2 DsrC like protein - - - 0.000000000000000000000000000000000000000002208 157.0
TLS3_k127_2487092_3 - - - - 0.000000000000000000000006164 104.0
TLS3_k127_2487092_4 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000008783 79.0
TLS3_k127_249191_0 AMP-binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 498.0
TLS3_k127_249191_1 AMP-binding enzyme - - - 0.000000000000000002153 94.0
TLS3_k127_249191_2 membrane - - - 0.0000000000001056 72.0
TLS3_k127_254919_0 RND efflux system, outer membrane lipoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 421.0
TLS3_k127_254919_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 402.0
TLS3_k127_257318_0 Dynamin family - - - 8.02e-203 652.0
TLS3_k127_257318_1 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 591.0
TLS3_k127_257318_10 methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000005917 212.0
TLS3_k127_257318_11 Ferredoxin - - - 0.0000000000000000000000000000000000000000004047 158.0
TLS3_k127_257318_12 VanZ like family - - - 0.00000000000000001095 87.0
TLS3_k127_257318_2 Peptidase M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 520.0
TLS3_k127_257318_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 470.0
TLS3_k127_257318_4 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 331.0
TLS3_k127_257318_5 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 304.0
TLS3_k127_257318_6 TIGRFAM cell division ATP-binding protein FtsE K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005395 277.0
TLS3_k127_257318_7 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000004094 256.0
TLS3_k127_257318_8 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005225 269.0
TLS3_k127_257318_9 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000001696 220.0
TLS3_k127_2577650_0 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 - - 6.559e-243 764.0
TLS3_k127_2577650_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 432.0
TLS3_k127_2577650_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 363.0
TLS3_k127_2577650_3 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 313.0
TLS3_k127_2577650_4 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 - 1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001513 278.0
TLS3_k127_2577650_5 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002265 274.0
TLS3_k127_2577650_6 - - - - 0.0000000000000000916 83.0
TLS3_k127_2585030_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 525.0
TLS3_k127_2585030_1 DNA segregation ATPase FtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003602 282.0
TLS3_k127_2585030_2 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000000000000002725 203.0
TLS3_k127_2585030_3 Smr protein MutS2 - - - 0.000000000000000000000000000000000000000000000000000008914 194.0
TLS3_k127_2594214_0 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 335.0
TLS3_k127_2594214_1 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004735 290.0
TLS3_k127_2594214_2 Biopolymer transport protein K03559 - - 0.00000000000000000000000000000000000000000000000000000009625 198.0
TLS3_k127_2594214_3 DnaJ molecular chaperone homology domain - - - 0.0000000000000002439 92.0
TLS3_k127_2594214_4 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000008591 62.0
TLS3_k127_2620879_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 491.0
TLS3_k127_2620879_1 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006516 481.0
TLS3_k127_2620879_2 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000000001883 206.0
TLS3_k127_2620879_3 Type 4 fimbrial biogenesis protein K02666 - - 0.00000000000000000000000000000000000000000000000003314 181.0
TLS3_k127_2625014_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 315.0
TLS3_k127_2625014_1 abc transporter K02003,K05685 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 321.0
TLS3_k127_2625014_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000001302 189.0
TLS3_k127_2634170_0 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 345.0
TLS3_k127_2634170_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007037 280.0
TLS3_k127_2634170_2 flavoprotein, PP_4765 family K07007 - - 0.0000000000000000006141 96.0
TLS3_k127_2638658_0 Belongs to the NifD NifK NifE NifN family K02587 - - 3.23e-262 813.0
TLS3_k127_2638658_1 Belongs to the NifD NifK NifE NifN family K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 525.0
TLS3_k127_2638658_10 Protein of unknown function (DUF2478) - - - 0.0000000000000000000000000000000000000000000007161 171.0
TLS3_k127_2638658_11 Ferredoxin - - - 0.00000000000000000000000000000000000002777 145.0
TLS3_k127_2638658_12 Transcriptional regulator K02019 - - 0.00000000000000000000000000000000004445 137.0
TLS3_k127_2638658_2 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 487.0
TLS3_k127_2638658_3 TIGRFAM molybdate ABC transporter K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 378.0
TLS3_k127_2638658_4 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 353.0
TLS3_k127_2638658_5 Nitrogen fixation protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003258 256.0
TLS3_k127_2638658_6 type III restriction protein res subunit K01153 - 3.1.21.3 0.00000000000000000000000000000000000000000000000000000000000000000000447 237.0
TLS3_k127_2638658_7 Pfam Dinitrogenase iron-molybdenum cofactor K02596 - - 0.0000000000000000000000000000000000000000000000000000000246 204.0
TLS3_k127_2638658_8 NifQ K15790 - - 0.0000000000000000000000000000000000000000000000082 179.0
TLS3_k127_2638658_9 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000001355 180.0
TLS3_k127_2644789_0 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000004157 246.0
TLS3_k127_2644789_1 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K14160 - - 0.00000000000000000000000000000000000000000000000000000000000002432 224.0
TLS3_k127_2644789_2 DNA polymerase involved in DNA repair K14161 - - 0.0000000000000000000000000000000000000000000007463 173.0
TLS3_k127_2665857_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1396.0
TLS3_k127_2665857_1 PFAM malic K00029 - 1.1.1.40 0.0 1017.0
TLS3_k127_2665857_10 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000401 148.0
TLS3_k127_2665857_2 Sulfatase - - - 1.919e-249 786.0
TLS3_k127_2665857_3 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 577.0
TLS3_k127_2665857_4 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 514.0
TLS3_k127_2665857_5 Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 299.0
TLS3_k127_2665857_6 Predicted membrane protein (DUF2238) K08984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002355 275.0
TLS3_k127_2665857_7 membrane protein, hemolysin III homolog K11068 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006772 267.0
TLS3_k127_2665857_8 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000009036 201.0
TLS3_k127_2665857_9 cytochrome - - - 0.000000000000000000000000000000000000005271 151.0
TLS3_k127_2668733_0 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 602.0
TLS3_k127_2668733_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 347.0
TLS3_k127_2668733_2 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 339.0
TLS3_k127_2668733_3 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 306.0
TLS3_k127_2668733_4 AAA domain K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 297.0
TLS3_k127_2668733_5 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000005219 230.0
TLS3_k127_2668733_6 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000004381 213.0
TLS3_k127_2668733_7 Single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.00000000000000000000000000000000009284 139.0
TLS3_k127_2672883_0 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily - - - 6.802e-287 899.0
TLS3_k127_2672883_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 590.0
TLS3_k127_2672883_10 Nuclear protein SET K07117 - - 0.00000000000000000000000000915 116.0
TLS3_k127_2672883_11 Hemerythrin-like metal-binding protein - - - 0.00000000000000000000001987 105.0
TLS3_k127_2672883_12 RNA-binding protein K14761 - - 0.00000000000000001023 84.0
TLS3_k127_2672883_13 Protein of unknown function (DUF1015) - - - 0.000000000000008945 75.0
TLS3_k127_2672883_2 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 566.0
TLS3_k127_2672883_3 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 343.0
TLS3_k127_2672883_4 DSBA Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 291.0
TLS3_k127_2672883_5 signal peptide protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 295.0
TLS3_k127_2672883_6 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006424 264.0
TLS3_k127_2672883_7 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000008989 171.0
TLS3_k127_2672883_8 protein with SCP PR1 domains - - - 0.0000000000000000000000000000000000000003371 156.0
TLS3_k127_2672883_9 Phosphate-starvation-inducible E - - - 0.000000000000000000000000005351 113.0
TLS3_k127_2676805_0 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 595.0
TLS3_k127_2676805_1 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 323.0
TLS3_k127_2676805_2 FMN_bind K03612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000316 276.0
TLS3_k127_2676805_3 Part of a membrane complex involved in electron transport K03615 - - 0.0000000000000000000000000000000000000000000000000000000000000002888 221.0
TLS3_k127_2676805_4 Part of a membrane complex involved in electron transport K03617 - - 0.0000000008855 61.0
TLS3_k127_2710624_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 512.0
TLS3_k127_2710624_1 Fe-S cluster K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 423.0
TLS3_k127_2710954_0 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 484.0
TLS3_k127_2710954_1 signal transduction protein containing EAL and modified HD-GYP - - - 0.0000000000000000000000000000000000000000000000000000002213 207.0
TLS3_k127_2710954_2 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.0000000000000000000000000000000000000000000000000000007587 198.0
TLS3_k127_2713723_0 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 578.0
TLS3_k127_2713723_1 ZIP Zinc transporter K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 424.0
TLS3_k127_2713723_2 Protein of unknown function (DUF2796) - - - 0.00000000000000000000000000000000000000000000000000000001412 203.0
TLS3_k127_2713723_3 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000002548 137.0
TLS3_k127_272104_0 Belongs to the DNA photolyase family K01669 - 4.1.99.3 3.655e-224 703.0
TLS3_k127_272104_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 556.0
TLS3_k127_272104_2 GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 521.0
TLS3_k127_272104_3 heat shock protein binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 510.0
TLS3_k127_272104_4 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 387.0
TLS3_k127_272104_5 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 373.0
TLS3_k127_272104_6 ferredoxin-NADP+ reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 336.0
TLS3_k127_272104_7 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000000004579 103.0
TLS3_k127_2735217_0 Ammonium Transporter Family K03320,K06580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 574.0
TLS3_k127_2735217_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007784 525.0
TLS3_k127_2735217_2 Methyl-transferase K18911 - 2.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000001874 260.0
TLS3_k127_2760568_0 AcrB/AcrD/AcrF family - - - 3.022e-320 989.0
TLS3_k127_2760568_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000002602 200.0
TLS3_k127_2766194_0 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 0.0 1345.0
TLS3_k127_2766194_1 Alkaline and neutral invertase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 435.0
TLS3_k127_277436_0 Bacterial protein of unknown function (DUF839) K07093 - - 3.732e-211 663.0
TLS3_k127_277436_1 SOS response associated peptidase (SRAP) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 368.0
TLS3_k127_277436_2 ThiS family K03636 - - 0.000000000000000000000000000002858 121.0
TLS3_k127_277436_3 protein related to plant photosystem II stability assembly factor - - - 0.00000000000000001052 82.0
TLS3_k127_277436_4 SNARE associated Golgi protein - - - 0.00000000000000002124 83.0
TLS3_k127_2788898_0 sulfatase - - - 9.68e-232 734.0
TLS3_k127_2788898_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 443.0
TLS3_k127_2788898_2 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009428 330.0
TLS3_k127_2788898_3 Sulfate transporter antisigma-factor antagonist STAS K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004576 285.0
TLS3_k127_2788898_4 Cobalamin adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000006649 250.0
TLS3_k127_2788898_5 - - - - 0.00000000000000000005805 94.0
TLS3_k127_2788898_6 Transcriptional regulatory protein, C terminal K07666 - - 0.00000000000005641 71.0
TLS3_k127_2820288_0 chemotaxis K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 385.0
TLS3_k127_2820288_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 311.0
TLS3_k127_2820288_2 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002611 240.0
TLS3_k127_2828905_0 amino acid K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 582.0
TLS3_k127_2828905_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs K05541 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 384.0
TLS3_k127_2828905_2 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000000002233 177.0
TLS3_k127_2828905_4 - - - - 0.0002336 46.0
TLS3_k127_2846296_0 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009511 486.0
TLS3_k127_2846296_1 Protein of unknown function (DUF1631) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 357.0
TLS3_k127_2864912_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 1.523e-296 921.0
TLS3_k127_2864912_1 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 434.0
TLS3_k127_2864912_2 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 392.0
TLS3_k127_2864912_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 378.0
TLS3_k127_2864912_4 Stress-induced protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 346.0
TLS3_k127_2864912_5 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 302.0
TLS3_k127_2864912_6 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 297.0
TLS3_k127_2864912_7 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000003997 105.0
TLS3_k127_2864912_8 pathogenesis - - - 0.00001565 51.0
TLS3_k127_2870468_0 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 528.0
TLS3_k127_2870468_1 epimerase dehydratase K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 494.0
TLS3_k127_2870468_2 COG0524 Sugar kinases, ribokinase family K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 487.0
TLS3_k127_2870468_3 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 391.0
TLS3_k127_2870468_4 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009877 364.0
TLS3_k127_2870468_5 acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000001077 207.0
TLS3_k127_2870468_6 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000007107 177.0
TLS3_k127_2870468_7 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.0000000000000000000000002866 109.0
TLS3_k127_2891844_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 7.994e-230 716.0
TLS3_k127_2891844_1 Domain of unknown function (DUF3391) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 413.0
TLS3_k127_2891844_2 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 345.0
TLS3_k127_2891844_3 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 329.0
TLS3_k127_2891844_4 coa-binding K06929 - - 0.000000000000000000000000000000000000000000000000004574 184.0
TLS3_k127_2891844_5 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 0.0000000003178 65.0
TLS3_k127_2891844_6 - - - - 0.0000000007859 65.0
TLS3_k127_2893693_0 Mandelate Racemase Muconate Lactonizing K01781,K20023,K20549 - 4.2.1.156,4.2.1.42,5.1.2.2,5.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 505.0
TLS3_k127_2893693_1 Bacterial regulatory helix-turn-helix protein, lysR family K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 368.0
TLS3_k127_2893693_2 Peptidogalycan biosysnthesis/recognition K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007493 341.0
TLS3_k127_2894534_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 4.38e-236 764.0
TLS3_k127_2894534_2 Protein of unknown function (DUF1631) - - - 0.000000155 57.0
TLS3_k127_289907_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0 1049.0
TLS3_k127_289907_1 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 4.071e-288 899.0
TLS3_k127_289907_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 7.241e-267 830.0
TLS3_k127_289907_3 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 2.94e-207 670.0
TLS3_k127_289907_4 AcyL-CoA dehydrogenase K06445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005934 589.0
TLS3_k127_289907_5 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000000000000000003442 192.0
TLS3_k127_289907_6 transcriptional - - - 0.00000000000000000000000000000000000000000000000000259 183.0
TLS3_k127_289907_7 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000000006228 176.0
TLS3_k127_289907_8 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000002799 72.0
TLS3_k127_2908914_0 Histidine kinase K07637 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 589.0
TLS3_k127_2908914_1 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress K05916,K07006,K21832 - 1.14.12.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006962 495.0
TLS3_k127_2908914_2 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 371.0
TLS3_k127_2908914_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 300.0
TLS3_k127_2908914_4 Class III cytochrome C family - - - 0.00000000000000000000000000009296 119.0
TLS3_k127_2908914_5 Propeptide PepSY amd peptidase M4 - - - 0.000000000000000000000000021 113.0
TLS3_k127_2909933_0 methyl-accepting chemotaxis protein K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 413.0
TLS3_k127_2909933_1 COG2202 FOG PAS PAC domain K03776 - - 0.0000000000000000000000000000007275 132.0
TLS3_k127_2966130_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1246.0
TLS3_k127_2966130_1 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008705 555.0
TLS3_k127_2966130_10 KTSC domain - - - 0.000000000000000000000000000000003882 129.0
TLS3_k127_2966130_11 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000001446 92.0
TLS3_k127_2966130_12 Protein of unknown function (DUF721) - - - 0.000000000000000005592 89.0
TLS3_k127_2966130_13 - - - - 0.00000003242 60.0
TLS3_k127_2966130_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 551.0
TLS3_k127_2966130_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 492.0
TLS3_k127_2966130_4 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009726 468.0
TLS3_k127_2966130_5 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 394.0
TLS3_k127_2966130_6 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 306.0
TLS3_k127_2966130_7 Class II aldolase adducin family protein K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 294.0
TLS3_k127_2966130_8 D-ala D-ala ligase N-terminus K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 288.0
TLS3_k127_2966130_9 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007116 255.0
TLS3_k127_2971695_0 NfeD-like C-terminal, partner-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 438.0
TLS3_k127_2971695_1 Protein of unknown function (DUF1223) - - - 0.000000000000000000000000000000000000000000000000000000000000000001963 251.0
TLS3_k127_2971695_2 prohibitin homologues - - - 0.000000000000000000000000000000000000000000007973 176.0
TLS3_k127_2972413_0 Domain related to MnhB subunit of Na+/H+ antiporter K05559 - - 0.0 1065.0
TLS3_k127_2972413_1 Periplasmic copper-binding protein (NosD) K07218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 544.0
TLS3_k127_2972413_2 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 453.0
TLS3_k127_2972413_3 LysR substrate binding domain K03717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 406.0
TLS3_k127_2972413_4 Belongs to the BI1 family K19416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008956 353.0
TLS3_k127_2972413_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 334.0
TLS3_k127_2972413_6 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000001014 204.0
TLS3_k127_2972413_7 histidine kinase, dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000004962 194.0
TLS3_k127_2983158_0 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001887 255.0
TLS3_k127_2983158_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006823 239.0
TLS3_k127_299760_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 0.0 1043.0
TLS3_k127_299760_1 Belongs to the ParA family K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008955 486.0
TLS3_k127_299760_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001379 228.0
TLS3_k127_299760_3 AAA ATPase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000002095 156.0
TLS3_k127_299760_4 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell K03608 - - 0.00000000000000000000000000000000000002478 147.0
TLS3_k127_3067663_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1266.0
TLS3_k127_3067663_1 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000083 355.0
TLS3_k127_3067663_2 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 307.0
TLS3_k127_3067663_3 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005199 251.0
TLS3_k127_3067663_4 NfeD-like C-terminal, partner-binding K07340 - - 0.0000000000000000000000000000000000000000000000002121 179.0
TLS3_k127_3067663_5 transport system periplasmic component K01989 - - 0.0000000000000000000000000000000000004367 152.0
TLS3_k127_3090321_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 2.366e-281 872.0
TLS3_k127_3090321_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 4.906e-197 621.0
TLS3_k127_3090321_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 322.0
TLS3_k127_3090321_3 Domain of unknown function (DUF1841) - - - 0.00000000000000000000000000000000000000000000000001131 183.0
TLS3_k127_3094679_0 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 304.0
TLS3_k127_3094679_1 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000121 282.0
TLS3_k127_3094679_2 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000108 187.0
TLS3_k127_3134261_0 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 365.0
TLS3_k127_3134261_1 NusG domain II - - - 0.000000000000000000000000000000000000000000001445 177.0
TLS3_k127_3134261_2 LysR substrate binding domain - - - 0.000000000000000000000000000000000001405 143.0
TLS3_k127_3134261_3 Tfp pilus assembly protein FimV - - - 0.00000000000000000001024 94.0
TLS3_k127_3135794_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 3.959e-251 783.0
TLS3_k127_314099_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1034.0
TLS3_k127_314099_1 GTP-binding protein TypA K06207 - - 3.617e-231 721.0
TLS3_k127_314099_2 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 466.0
TLS3_k127_314099_3 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 448.0
TLS3_k127_314099_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 411.0
TLS3_k127_314099_5 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 408.0
TLS3_k127_314099_6 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 356.0
TLS3_k127_314099_7 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000149 79.0
TLS3_k127_3158851_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 2.089e-314 971.0
TLS3_k127_3158851_1 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 1.284e-221 689.0
TLS3_k127_3158851_10 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.0000000000000000000000000001107 116.0
TLS3_k127_3158851_11 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000006394 84.0
TLS3_k127_3158851_2 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 3.475e-203 642.0
TLS3_k127_3158851_3 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 557.0
TLS3_k127_3158851_4 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 519.0
TLS3_k127_3158851_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 503.0
TLS3_k127_3158851_6 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005815 376.0
TLS3_k127_3158851_7 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000067 376.0
TLS3_k127_3158851_8 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000000000000000000000000004435 191.0
TLS3_k127_3158851_9 SpoIIAA-like - - - 0.00000000000000000000000000000000000000105 156.0
TLS3_k127_3204681_0 Protein of unknown function (DUF1615) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 482.0
TLS3_k127_3204681_1 Sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 418.0
TLS3_k127_3204681_2 depolymerase K05973 - 3.1.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 387.0
TLS3_k127_3204681_3 Beta-ketoacyl synthase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 347.0
TLS3_k127_3204681_4 NAD dependent epimerase/dehydratase family K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 347.0
TLS3_k127_3204681_5 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000479 254.0
TLS3_k127_3204681_6 dehydratase - - - 0.0000000000000000000000000000000000000000000000004305 191.0
TLS3_k127_3204681_7 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 0.00000000000232 67.0
TLS3_k127_3209994_0 Diguanylate cyclase - - - 5.809e-248 801.0
TLS3_k127_3209994_1 Periplasmic binding proteins and sugar binding domain of LacI family K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 332.0
TLS3_k127_3209994_2 Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000000000000000000001937 151.0
TLS3_k127_3209994_3 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.0007567 47.0
TLS3_k127_3234739_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 326.0
TLS3_k127_3234739_1 Type II secretion system (T2SS), protein G K02456 - - 0.0000000000000000000000000000000000000000000000000000000000000003366 223.0
TLS3_k127_3234739_2 Transglycosylase SLT domain K01185 - 3.2.1.17 0.00000000000000000000000000000000000000000000000001209 187.0
TLS3_k127_3234739_3 Type II secretion system (T2SS), protein F K02455 - - 0.000000000000000000000000000000000000000006418 162.0
TLS3_k127_3234739_4 Pfam Response regulator receiver - - - 0.00000000000000000000000007625 113.0
TLS3_k127_3309707_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.509e-203 644.0
TLS3_k127_3358311_0 Diguanylate cyclase - - - 3.426e-229 730.0
TLS3_k127_3358311_1 BAAT Acyl-CoA thioester hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 326.0
TLS3_k127_3358311_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009413 295.0
TLS3_k127_3358311_3 NADH flavin oxidoreductase NADH oxidase K10680 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 289.0
TLS3_k127_3358311_4 'signal transduction protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001443 296.0
TLS3_k127_3358311_5 Belongs to the UPF0502 family K09915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003174 268.0
TLS3_k127_3358311_6 translation initiation factor activity K03086 - - 0.0000000000000000002555 98.0
TLS3_k127_3358311_7 Protein of unknown function, DUF481 - - - 0.000000002999 68.0
TLS3_k127_339575_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007609 529.0
TLS3_k127_339575_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 490.0
TLS3_k127_339575_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009851 389.0
TLS3_k127_339575_3 riboflavin synthase, alpha K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 286.0
TLS3_k127_339575_4 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000000000000000000000000000000001446 211.0
TLS3_k127_339575_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000006721 202.0
TLS3_k127_339575_6 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000001306 191.0
TLS3_k127_339575_7 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000002915 166.0
TLS3_k127_339575_8 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.0000000000000000000000000000000000000003042 150.0
TLS3_k127_3449489_0 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 433.0
TLS3_k127_3449489_1 Glycosyltransferase like family 2 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 416.0
TLS3_k127_3449489_2 MltA-interacting protein MipA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000982 372.0
TLS3_k127_3449489_3 pteridine-dependent deoxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 356.0
TLS3_k127_3449489_4 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008801 359.0
TLS3_k127_3449489_5 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006554 341.0
TLS3_k127_3449489_6 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 320.0
TLS3_k127_3451824_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 1.707e-195 617.0
TLS3_k127_3451824_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006792 429.0
TLS3_k127_3451824_2 coenzyme F390 K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000009247 248.0
TLS3_k127_3451824_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000004909 224.0
TLS3_k127_3451824_4 preprotein translocase subunit YajC K03210 - - 0.00000000000000000000000000000000000000004453 155.0
TLS3_k127_3451824_5 GAF domain - - - 0.0000000000000000000000000000000003752 142.0
TLS3_k127_3451824_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000001665 59.0
TLS3_k127_345735_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 606.0
TLS3_k127_345735_1 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001011 268.0
TLS3_k127_3469211_0 Thioredoxin domain K03387 - - 9.153e-222 700.0
TLS3_k127_3469211_1 C-terminal domain of 1-Cys peroxiredoxin K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000004045 234.0
TLS3_k127_3501309_0 Acyl-CoA synthetase (NDP forming) K09181 - - 0.0 1232.0
TLS3_k127_3501309_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 6.272e-204 638.0
TLS3_k127_3501309_2 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009045 572.0
TLS3_k127_3501309_3 GTP cyclohydrolase K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 360.0
TLS3_k127_3501309_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009146 346.0
TLS3_k127_3501309_5 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003122 258.0
TLS3_k127_3501309_6 YaeQ - - - 0.0000000000000000000000000000000000000000000000000000000000000008269 223.0
TLS3_k127_3501309_7 tellurite resistance protein - - - 0.000000000000000000000000000000000000000000000000000000000000004178 221.0
TLS3_k127_3501309_8 Thioredoxin K05838 - - 0.0000000000000000000000000000000000000000000000001055 182.0
TLS3_k127_3501309_9 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00000000000000000000000000000000001236 144.0
TLS3_k127_3502685_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1095.0
TLS3_k127_3502685_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 539.0
TLS3_k127_3502685_10 Putative regulatory protein - - - 0.000000000000000000000000000000000009509 141.0
TLS3_k127_3502685_11 Guanyl-specific ribonuclease Sa - - - 0.00000000000000000000000000000000002006 144.0
TLS3_k127_3502685_12 Barstar (barnase inhibitor) - - - 0.000000000000000000000000000000009853 132.0
TLS3_k127_3502685_13 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000001112 82.0
TLS3_k127_3502685_14 Cysteine-rich CWC - - - 0.00000001312 58.0
TLS3_k127_3502685_15 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0001941 51.0
TLS3_k127_3502685_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 492.0
TLS3_k127_3502685_3 had-superfamily hydrolase subfamily ia, variant 3 K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 292.0
TLS3_k127_3502685_4 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 283.0
TLS3_k127_3502685_5 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001244 273.0
TLS3_k127_3502685_6 cytochrome - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001273 257.0
TLS3_k127_3502685_7 Bacterial regulatory proteins, tetR family K05501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001029 252.0
TLS3_k127_3502685_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000000000000000006233 211.0
TLS3_k127_3502685_9 NUDIX domain K08310 - 3.6.1.67 0.000000000000000000000000000000000000000000000000000004886 200.0
TLS3_k127_3503240_0 ABC transporter transmembrane region K06147 - - 0.0 1169.0
TLS3_k127_3503240_1 RimK-like ATP-grasp domain K03802 - 6.3.2.29,6.3.2.30 3.9e-322 1026.0
TLS3_k127_3503240_2 cyanophycin synthetase K03802 - 6.3.2.29,6.3.2.30 1.111e-288 902.0
TLS3_k127_3503240_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000005132 256.0
TLS3_k127_3503240_4 Domain of unknown function (DUF1854) - - - 0.000000000000000000000000000000000000000000000000000000000000007509 220.0
TLS3_k127_3503240_5 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000000000000000000000000000197 211.0
TLS3_k127_3503240_6 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000000000001121 190.0
TLS3_k127_3508588_0 Diguanylate cyclase - - - 2.754e-213 693.0
TLS3_k127_3508588_1 - - - - 0.00000000000000000000000000000000000000000000000000001018 199.0
TLS3_k127_3508588_2 5'-nucleotidase - - - 0.00000000000000000000000000000000000000000002973 163.0
TLS3_k127_3518390_0 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 582.0
TLS3_k127_3518390_1 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 557.0
TLS3_k127_3524125_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 608.0
TLS3_k127_3524125_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K03472 - 1.2.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 473.0
TLS3_k127_3524125_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007282 451.0
TLS3_k127_3524125_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000001641 231.0
TLS3_k127_3524125_4 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000000000000005998 201.0
TLS3_k127_3524125_5 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000003892 174.0
TLS3_k127_3524125_6 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000000000000936 134.0
TLS3_k127_3526206_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 1.617e-235 731.0
TLS3_k127_3526206_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 520.0
TLS3_k127_3526206_2 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 516.0
TLS3_k127_3526206_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 483.0
TLS3_k127_3526206_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 389.0
TLS3_k127_3526206_5 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 350.0
TLS3_k127_3526206_6 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000461 255.0
TLS3_k127_3526206_7 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates - - - 0.000000000000000008667 93.0
TLS3_k127_3530264_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1443.0
TLS3_k127_3530264_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 7.539e-223 696.0
TLS3_k127_3530264_2 ZIP Zinc transporter K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004214 405.0
TLS3_k127_3530264_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 301.0
TLS3_k127_3530264_4 Flagellar protein YcgR - - - 0.0000000000000000000000000000000000000000000000000000000009436 211.0
TLS3_k127_3530264_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18306 - - 0.0000000000000000000000000000000000000000000000000000003037 201.0
TLS3_k127_3530264_6 response to antibiotic - - - 0.0000000000000000000000000000000000000000000000000009155 198.0
TLS3_k127_3530264_7 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000000001609 139.0
TLS3_k127_3551500_0 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 1.258e-265 828.0
TLS3_k127_3551500_1 chemotaxis, protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000051 237.0
TLS3_k127_3551500_2 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000001399 214.0
TLS3_k127_3551500_3 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000001761 202.0
TLS3_k127_3551500_4 Phasin protein - - - 0.0000000000000000000000000000000000001424 147.0
TLS3_k127_3555924_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 521.0
TLS3_k127_3555924_1 branched-chain amino acid K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009952 368.0
TLS3_k127_3555924_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000002138 195.0
TLS3_k127_3555924_3 ABC transporter K01996 - - 0.00000000000000000006258 92.0
TLS3_k127_3562849_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 3.24e-196 619.0
TLS3_k127_3562849_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 455.0
TLS3_k127_3562849_2 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002912 284.0
TLS3_k127_3562849_3 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.00000000000000000000000000000000000000007707 161.0
TLS3_k127_3562849_4 Thioesterase domain K02170 - 3.1.1.85 0.0000000000000000000000000000000000000002926 169.0
TLS3_k127_3596998_0 nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC K02567 - - 6.917e-234 728.0
TLS3_k127_3596998_1 Cytochrome c554 and c-prime - - - 3.964e-213 666.0
TLS3_k127_3596998_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07673 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 347.0
TLS3_k127_3596998_3 helix_turn_helix, Lux Regulon K07684 - - 0.00000000000000000000000000000000000000000000000000000000000000000001207 239.0
TLS3_k127_3596998_4 NapD protein K02570 - - 0.00000000000000006106 84.0
TLS3_k127_3606047_0 glutamine synthetase K01915 - 6.3.1.2 6.649e-195 609.0
TLS3_k127_3606047_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009982 597.0
TLS3_k127_3606047_2 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 451.0
TLS3_k127_3606047_3 Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004787 402.0
TLS3_k127_3606047_4 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 385.0
TLS3_k127_3606047_5 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 377.0
TLS3_k127_3606047_6 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 309.0
TLS3_k127_3606047_7 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007978 294.0
TLS3_k127_3606047_8 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009321 261.0
TLS3_k127_3606047_9 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000002867 175.0
TLS3_k127_3615991_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K21834 - - 3.781e-236 743.0
TLS3_k127_3615991_1 nitrate reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008284 277.0
TLS3_k127_3615991_2 Nickel-dependent hydrogenase K05922,K06281 - 1.12.5.1,1.12.99.6 0.00000000000000000000000000000000001911 136.0
TLS3_k127_3615991_3 - - - - 0.0000000000000001689 85.0
TLS3_k127_3617679_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K12276 - - 1.75e-271 845.0
TLS3_k127_3617679_1 Concanavalin A-like lectin/glucanases superfamily K12287 - - 3.556e-248 809.0
TLS3_k127_3617679_2 Type II secretion system (T2SS), protein F K02455,K12278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 571.0
TLS3_k127_3617679_3 Prokaryotic N-terminal methylation motif K10924 - - 0.00000000000000000000000000000001861 132.0
TLS3_k127_3617679_4 Metallo-peptidase family M12B Reprolysin-like - - - 0.0000000000000698 87.0
TLS3_k127_3617679_5 Prokaryotic N-terminal methylation motif - - - 0.00009819 55.0
TLS3_k127_3626790_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit K00342 - 1.6.5.3 6.048e-308 966.0
TLS3_k127_3626790_1 SpoVR family - - - 2.131e-257 807.0
TLS3_k127_3626790_2 Na H antiporter, MnhB K05566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 318.0
TLS3_k127_3626790_3 Belongs to the UPF0229 family K09786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007206 254.0
TLS3_k127_3626790_4 Na H antiporter K05569 - - 0.000000000000000000000000000000000000000000000000000000000008046 212.0
TLS3_k127_3626790_5 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.00000000000000000000000000000000000000001133 166.0
TLS3_k127_3626790_6 monovalent cation proton antiporter, MnhG PhaG subunit - - - 0.00000000000000000000000000000000000000001836 159.0
TLS3_k127_3626790_7 Domain of unknown function (DUF4040) - - - 0.000000000000000001006 93.0
TLS3_k127_3626790_8 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.0000000000000128 76.0
TLS3_k127_36270_0 serine threonine protein kinase - - - 3.479e-302 946.0
TLS3_k127_36270_1 Hsp90 protein K04079 - - 3.936e-212 663.0
TLS3_k127_36270_2 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000872 484.0
TLS3_k127_36270_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008628 260.0
TLS3_k127_3628413_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 8.531e-298 923.0
TLS3_k127_3628413_1 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 346.0
TLS3_k127_3628413_2 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.0000000000000000000000000000000000000000000000000000000000000001625 230.0
TLS3_k127_3628413_3 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.0000000000000000000008421 112.0
TLS3_k127_3643759_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 2.095e-274 857.0
TLS3_k127_3644754_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 9.348e-209 652.0
TLS3_k127_3644754_1 dihydropteroate synthase K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 354.0
TLS3_k127_3654879_0 PrkA family serine protein kinase K07180 - - 0.0 1154.0
TLS3_k127_3654879_1 Putative diguanylate phosphodiesterase - - - 0.0 1045.0
TLS3_k127_3654879_2 Ferrous iron transport protein B K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007566 492.0
TLS3_k127_3654879_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 444.0
TLS3_k127_3654879_4 Belongs to the UPF0229 family K09786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008151 365.0
TLS3_k127_3655882_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 375.0
TLS3_k127_3655882_1 Histidine kinase K20975 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 366.0
TLS3_k127_3665876_0 AcyL-CoA dehydrogenase K06445 - - 0.0 1268.0
TLS3_k127_3665876_1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 6.502e-213 673.0
TLS3_k127_3665876_2 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 540.0
TLS3_k127_3665876_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000001901 72.0
TLS3_k127_3724208_0 TRAP transporter solute receptor TAXI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 432.0
TLS3_k127_3724208_1 Belongs to the heme-copper respiratory oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001716 286.0
TLS3_k127_3724208_2 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000384 272.0
TLS3_k127_3724208_3 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K21345 - 2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000027 263.0
TLS3_k127_3724208_4 Crp Fnr family transcriptional regulator K21563 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003593 275.0
TLS3_k127_3724208_5 periplasmic or secreted lipoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000106 225.0
TLS3_k127_3724208_6 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000004183 151.0
TLS3_k127_3724208_7 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.00000000000000000000000000000000000000718 153.0
TLS3_k127_3724208_8 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000011 128.0
TLS3_k127_3724208_9 conserved protein (DUF2249) - - - 0.0000000000009902 70.0
TLS3_k127_3731072_0 Histidine kinase K07638 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 428.0
TLS3_k127_3731072_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07659 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 356.0
TLS3_k127_3731072_2 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 340.0
TLS3_k127_3731072_3 uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 323.0
TLS3_k127_3731072_4 TPM domain K06872 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001865 284.0
TLS3_k127_3731072_5 Peptidase M22 glycoprotease K14742 - - 0.0000000000000000000000000000000000000000000000000000000003099 209.0
TLS3_k127_3731072_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000000000000000000004534 159.0
TLS3_k127_3731072_7 Glycosyl transferase family 1 - - - 0.000000000000000000000000000000000003466 152.0
TLS3_k127_3731072_8 Pfam:TPM - - - 0.0000000000000000000000002611 110.0
TLS3_k127_3745239_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 3.103e-249 773.0
TLS3_k127_3745239_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008838 583.0
TLS3_k127_3745239_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 549.0
TLS3_k127_3745239_3 Methyltransferase small domain K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000683 286.0
TLS3_k127_3745239_4 - - - - 0.00000000000000000000000000000114 126.0
TLS3_k127_3745239_5 Glycine-zipper domain - - - 0.00000000000000000000000000001467 124.0
TLS3_k127_3745239_6 part of a sulfur-relay system K11179 - - 0.00000006473 55.0
TLS3_k127_3748817_0 diguanylate cyclase - - - 2.464e-269 852.0
TLS3_k127_3748817_1 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 454.0
TLS3_k127_3748817_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004438 430.0
TLS3_k127_3748817_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005363 424.0
TLS3_k127_3748817_4 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004893 278.0
TLS3_k127_3748817_5 Ribonuclease III family K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000003777 269.0
TLS3_k127_3748817_6 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000005326 149.0
TLS3_k127_3748817_7 Domain of unknown function (DUF4845) - - - 0.0000000000000000000000000001336 121.0
TLS3_k127_3748817_8 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000001139 91.0
TLS3_k127_3780283_0 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 515.0
TLS3_k127_3780283_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000006263 154.0
TLS3_k127_3782508_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1138.0
TLS3_k127_3782508_1 Protein of unknown function (DUF3750) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 343.0
TLS3_k127_3782508_2 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.000000000000000000000000000000000000174 142.0
TLS3_k127_3803181_0 His Kinase A (phospho-acceptor) domain - - - 0.0 1242.0
TLS3_k127_3803181_1 DNA polymerase III K02342 - 2.7.7.7 5.344e-315 980.0
TLS3_k127_3803181_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000005941 205.0
TLS3_k127_3803181_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000001954 109.0
TLS3_k127_3813431_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.152e-264 816.0
TLS3_k127_3813431_1 PFAM PEBP family protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000001868 225.0
TLS3_k127_3813431_2 Domain of unknown function (DUF3391) - - - 0.00000000000000000000000000000000000000000000005899 170.0
TLS3_k127_3813431_3 Domain of unknown function (DUF4124) - - - 0.000000000009969 71.0
TLS3_k127_3929870_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 4.902e-249 784.0
TLS3_k127_3929870_1 2-hydroxy-3-oxopropionate reductase K00042 - 1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 411.0
TLS3_k127_3929870_2 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 294.0
TLS3_k127_3929870_3 PFAM isocitrate lyase and phosphorylmutase K01637 - 4.1.3.1 0.0000000000000000000000000000000000000000000000078 171.0
TLS3_k127_3932546_0 Oligopeptidase K01414 - 3.4.24.70 2.243e-294 912.0
TLS3_k127_3932546_1 Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a - - - 0.00000000000000000000005862 100.0
TLS3_k127_3932905_0 PFAM Integrase catalytic region K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008417 461.0
TLS3_k127_3932905_1 PFAM transposase IS3 IS911 family protein K07483 - - 0.00000000000000000000000000000000000000009941 153.0
TLS3_k127_3932905_2 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000000002082 62.0
TLS3_k127_3932905_3 Belongs to the 'phage' integrase family - - - 0.00001219 52.0
TLS3_k127_3948245_0 Cytochrome c7 and related cytochrome c - - - 3.32e-308 983.0
TLS3_k127_3948245_1 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 616.0
TLS3_k127_3948835_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1395.0
TLS3_k127_3948835_1 PFAM Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase - - - 0.0 1265.0
TLS3_k127_3948835_2 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007602 473.0
TLS3_k127_3948835_3 Prokaryotic cytochrome b561 K12262 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004722 276.0
TLS3_k127_3948835_4 ribosome binding K05594 - - 0.000000000000000000001444 99.0
TLS3_k127_3948835_5 Protein of unknown function (DUF3309) - - - 0.00000000000000000002463 92.0
TLS3_k127_3948835_6 - - - - 0.000000000000002624 81.0
TLS3_k127_3949297_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.675e-227 708.0
TLS3_k127_3949297_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008891 505.0
TLS3_k127_3961228_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 3.815e-254 799.0
TLS3_k127_3961228_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 516.0
TLS3_k127_3961228_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 457.0
TLS3_k127_3961228_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 407.0
TLS3_k127_3961228_4 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000000000000007094 100.0
TLS3_k127_3976895_0 carboxylase K01965 - 6.4.1.3 0.0 1004.0
TLS3_k127_3976895_1 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 6.017e-307 948.0
TLS3_k127_3976895_2 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 5.941e-304 935.0
TLS3_k127_3976895_3 Putative diguanylate phosphodiesterase K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 568.0
TLS3_k127_3976895_4 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 441.0
TLS3_k127_3976895_5 Neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 395.0
TLS3_k127_3976895_6 Lactoylglutathione lyase K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 289.0
TLS3_k127_3976895_7 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000142 222.0
TLS3_k127_3976895_8 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000008332 119.0
TLS3_k127_3989560_0 Protein of unknown function - - - 0.0 1064.0
TLS3_k127_3989560_1 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 393.0
TLS3_k127_3989560_2 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 349.0
TLS3_k127_3995987_0 Membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 463.0
TLS3_k127_3995987_1 ATPase (AAA K06923 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 413.0
TLS3_k127_3995987_2 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000006208 248.0
TLS3_k127_3995987_3 Ammonium Transporter Family K03320,K06580 - - 0.000000000000000000000000000000000000000000000000000002354 194.0
TLS3_k127_4025271_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.198e-266 833.0
TLS3_k127_4025271_1 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 312.0
TLS3_k127_4025271_2 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000002285 175.0
TLS3_k127_4025271_3 cell division protein - - - 0.00000000000000000000000000000001141 135.0
TLS3_k127_4047113_0 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 1.522e-197 617.0
TLS3_k127_4047113_1 Phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 531.0
TLS3_k127_4047113_2 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005906 548.0
TLS3_k127_4047113_3 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000984 482.0
TLS3_k127_4047113_4 Amidohydrolase K01686 - 4.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 362.0
TLS3_k127_4047113_5 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000175 277.0
TLS3_k127_4047113_6 membrane - - - 0.0000000000000000000000000000000000000000000000000009066 186.0
TLS3_k127_4047113_7 MlaD protein K06192 - - 0.0000000000000000000000000000000000000000003846 168.0
TLS3_k127_4075183_0 AcrB/AcrD/AcrF family - - - 0.0 1308.0
TLS3_k127_4075183_1 Carbamoyltransferase C-terminus K00612 - - 0.0 1096.0
TLS3_k127_4075183_10 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 295.0
TLS3_k127_4075183_11 Glycosyl transferases group 1 K06320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 295.0
TLS3_k127_4075183_12 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 285.0
TLS3_k127_4075183_13 HlyD family secretion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001049 286.0
TLS3_k127_4075183_14 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001513 250.0
TLS3_k127_4075183_15 Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000528 247.0
TLS3_k127_4075183_16 Thermostable hemolysin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007068 245.0
TLS3_k127_4075183_17 Long-chain fatty acid--CoA ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000006457 237.0
TLS3_k127_4075183_18 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000005486 226.0
TLS3_k127_4075183_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000007005 244.0
TLS3_k127_4075183_2 Amp-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006255 598.0
TLS3_k127_4075183_20 Bacterial transcriptional repressor C-terminal K09017 - - 0.00000000000000000000000000000000000000000000000000005177 194.0
TLS3_k127_4075183_21 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000000000000000000000001 195.0
TLS3_k127_4075183_22 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000000000001497 143.0
TLS3_k127_4075183_23 Tfp pilus assembly protein FimV - - - 0.000000001568 70.0
TLS3_k127_4075183_3 Two-component sensor kinase N-terminal K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 479.0
TLS3_k127_4075183_4 COG1538 Outer membrane protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009868 470.0
TLS3_k127_4075183_5 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 460.0
TLS3_k127_4075183_6 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 454.0
TLS3_k127_4075183_7 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 359.0
TLS3_k127_4075183_8 response regulator K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 351.0
TLS3_k127_4075183_9 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 341.0
TLS3_k127_4078623_0 RNB K01147 - 3.1.13.1 2.431e-249 791.0
TLS3_k127_4078623_1 Domain of unknown function (DUF3391) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009954 588.0
TLS3_k127_4078623_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 447.0
TLS3_k127_4078623_3 Uncharacterised protein family (UPF0227) K07000 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000399 261.0
TLS3_k127_4078623_4 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000001443 184.0
TLS3_k127_4142061_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1266.0
TLS3_k127_4142061_1 Ribonuclease E/G family K08301 - - 3.898e-223 704.0
TLS3_k127_4142061_10 NlpC/P60 family - - - 0.000000000000000000000000000000000000000002626 156.0
TLS3_k127_4142061_11 - - - - 0.00000000000000000000000000000000000000002133 162.0
TLS3_k127_4142061_12 Protein of unknown function (DUF2782) - - - 0.0000000000000000000000000000001885 126.0
TLS3_k127_4142061_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 540.0
TLS3_k127_4142061_3 dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000917 396.0
TLS3_k127_4142061_4 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 364.0
TLS3_k127_4142061_5 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001007 254.0
TLS3_k127_4142061_6 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001602 255.0
TLS3_k127_4142061_7 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000005032 238.0
TLS3_k127_4142061_8 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000000000000000000000001921 226.0
TLS3_k127_4142061_9 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000000008581 178.0
TLS3_k127_422076_0 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000925 188.0
TLS3_k127_422076_1 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000000000000000007695 160.0
TLS3_k127_422076_2 Thioredoxin domain K03387 - - 0.000000000000000000000000000000000000002231 147.0
TLS3_k127_422076_3 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000000001588 154.0
TLS3_k127_4304497_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 313.0
TLS3_k127_4304497_1 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000004425 183.0
TLS3_k127_4304497_2 Winged helix-turn helix - - - 0.00000000002644 75.0
TLS3_k127_4309039_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K21307 - 1.8.5.6 0.0 1266.0
TLS3_k127_4309039_1 PFAM 4Fe-4S K00184,K21308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 469.0
TLS3_k127_4309039_2 DMSO reductase anchor subunit (DmsC) K21309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 461.0
TLS3_k127_4309039_3 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000004166 178.0
TLS3_k127_4309039_4 Sulfurtransferase TusA K04085 - - 0.00000000000000000000000000000001085 129.0
TLS3_k127_4324144_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 5.582e-210 659.0
TLS3_k127_4324144_1 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 452.0
TLS3_k127_4324144_2 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007462 398.0
TLS3_k127_4324144_3 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 370.0
TLS3_k127_4324144_4 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000279 278.0
TLS3_k127_4324144_5 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.0000000000000000000000000000000000002925 142.0
TLS3_k127_4324144_6 - - - - 0.000000000000001168 80.0
TLS3_k127_4326627_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 527.0
TLS3_k127_4326627_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007783 472.0
TLS3_k127_4364078_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 576.0
TLS3_k127_4364078_1 alpha/beta hydrolase fold K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 287.0
TLS3_k127_4364078_2 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0006291 42.0
TLS3_k127_438214_0 Pirin K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000009667 231.0
TLS3_k127_438214_1 DsrE/DsrF-like family K09004 - - 0.000000000000000000000000000000000000000509 152.0
TLS3_k127_438214_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000003969 152.0
TLS3_k127_438214_4 ABC transporter K01990 - - 0.0000007159 52.0
TLS3_k127_438214_5 - - - - 0.0007079 51.0
TLS3_k127_4406211_0 protein with a C-terminal OMP (outer membrane protein) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 441.0
TLS3_k127_4406211_1 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000002794 173.0
TLS3_k127_4418576_0 PFAM L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 501.0
TLS3_k127_4418576_1 extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 334.0
TLS3_k127_4419791_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 404.0
TLS3_k127_4419791_1 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009552 275.0
TLS3_k127_4419791_2 AcrB/AcrD/AcrF family K07787 - - 0.0000000000000000000000000000000000000000000000000000001941 196.0
TLS3_k127_4420640_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1263.0
TLS3_k127_4420640_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 493.0
TLS3_k127_4433796_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1322.0
TLS3_k127_4433796_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 7.145e-197 623.0
TLS3_k127_4433796_10 Ribonuclease P - - - 0.00000001503 62.0
TLS3_k127_4433796_2 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 541.0
TLS3_k127_4433796_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 489.0
TLS3_k127_4433796_4 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 429.0
TLS3_k127_4433796_5 membrane - - - 0.000000000000000000000000000000000001285 145.0
TLS3_k127_4433796_6 Phosphopantetheine attachment site K02078 - - 0.000000000000000000000000000006072 121.0
TLS3_k127_4433796_7 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000000001738 119.0
TLS3_k127_4433796_8 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000149 79.0
TLS3_k127_4433796_9 Phosphopantetheine attachment site K02078 - - 0.00000000000001334 76.0
TLS3_k127_448618_0 Cytochrome c K02198 - - 1.271e-300 941.0
TLS3_k127_448618_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 454.0
TLS3_k127_448618_2 Cytochrome c-type biogenesis protein K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 302.0
TLS3_k127_448618_3 oxidoreductase DsbE K02199 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008235 263.0
TLS3_k127_448618_4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000000000000000000000000001032 250.0
TLS3_k127_448618_5 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000000000000000000000000002794 224.0
TLS3_k127_448618_6 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.00000000000000000000000000000000000000000000003781 172.0
TLS3_k127_448618_7 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000000000000000000002126 175.0
TLS3_k127_448618_8 Protein of unknown function (DUF3460) - - - 0.000000000000000001979 91.0
TLS3_k127_448618_9 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.00000000000007882 76.0
TLS3_k127_4507976_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 1.491e-218 683.0
TLS3_k127_4507976_1 glycolate oxidase subunit GlcD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 605.0
TLS3_k127_4507976_2 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006367 368.0
TLS3_k127_4522111_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 6.622e-289 904.0
TLS3_k127_4522111_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 2.941e-238 754.0
TLS3_k127_4522111_2 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 1.617e-222 695.0
TLS3_k127_4522111_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 527.0
TLS3_k127_4522111_4 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 349.0
TLS3_k127_4522111_5 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 295.0
TLS3_k127_4522111_6 Smr protein MutS2 - - - 0.000000000000000000000000000000000000000000000000000000006346 203.0
TLS3_k127_4522111_7 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000000000002311 204.0
TLS3_k127_4522111_8 Heavy metal-associated domain protein K07213 - - 0.0000000000000003918 87.0
TLS3_k127_4543785_0 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 575.0
TLS3_k127_4543785_1 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 492.0
TLS3_k127_4543785_10 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.000000000000000000000000000000000000000000000000000000001871 209.0
TLS3_k127_4543785_11 Flagellar hook capping protein - N-terminal region K02389 - - 0.00000000000000000000000000000000000000000000000000000009002 202.0
TLS3_k127_4543785_12 Belongs to the flagella basal body rod proteins family K02388 - - 0.00000000000000000000000000000000000000000000000008302 183.0
TLS3_k127_4543785_13 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.0000000000000000000000000000000003493 138.0
TLS3_k127_4543785_14 FlgN protein K02399 - - 0.0000000000000000002229 96.0
TLS3_k127_4543785_15 Anti-sigma-28 factor, FlgM K02398 - - 0.000000000000001237 81.0
TLS3_k127_4543785_16 Cellulose biosynthesis protein BcsQ K04562 - - 0.00009998 48.0
TLS3_k127_4543785_2 Belongs to the flagella basal body rod proteins family K02392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 400.0
TLS3_k127_4543785_3 Flagellar basal body rod FlgEFG protein C-terminal K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006061 404.0
TLS3_k127_4543785_4 flagellar motor K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 372.0
TLS3_k127_4543785_5 basal body rod protein K02391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 334.0
TLS3_k127_4543785_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 334.0
TLS3_k127_4543785_7 Flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 303.0
TLS3_k127_4543785_8 Flagellar rod assembly protein muramidase FlgJ K02395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001007 263.0
TLS3_k127_4543785_9 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000000000000000000000000000000000000000000000000000000001036 233.0
TLS3_k127_4571156_0 Collagenase K08303 - - 6.567e-298 925.0
TLS3_k127_4571156_1 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 2.614e-206 656.0
TLS3_k127_4571156_2 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 326.0
TLS3_k127_4571156_3 chorismate binding enzyme K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000003505 126.0
TLS3_k127_4572170_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 591.0
TLS3_k127_4572170_1 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 424.0
TLS3_k127_4572170_2 Molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007676 314.0
TLS3_k127_4572170_3 FMN binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 314.0
TLS3_k127_4572170_4 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000003612 208.0
TLS3_k127_4572170_5 - - - - 0.0000000000000000000000000000000000000000000000000000001983 205.0
TLS3_k127_4572170_6 - - - - 0.000000000000000000000000000000000000000000000000000003083 193.0
TLS3_k127_4572170_7 Etoposide-induced protein 2.4 (EI24) - - - 0.000000000000000000000000000000000000000000001719 173.0
TLS3_k127_4572170_8 Phosphopantetheine attachment site K02078 - - 0.0000000000000000000000000000000000768 134.0
TLS3_k127_4576645_0 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 451.0
TLS3_k127_4576645_1 Flavocytochrome c sulphide dehydrogenase, flavin-binding K17229 - 1.8.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003842 285.0
TLS3_k127_4576645_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001868 278.0
TLS3_k127_4576645_3 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000785 246.0
TLS3_k127_4576645_4 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000008475 211.0
TLS3_k127_4588192_0 Cohesin domain K02453 - - 3.208e-211 681.0
TLS3_k127_4588192_1 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 299.0
TLS3_k127_4588192_2 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000000000000000000000004101 203.0
TLS3_k127_4588192_3 Type II secretory pathway, pseudopilin - - - 0.000000000000000000000000000000000000000000000001617 186.0
TLS3_k127_4588192_4 prepilin-type N-terminal cleavage methylation K02456 - - 0.0000000000000000000000000000000000000000000147 173.0
TLS3_k127_4590166_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 3.412e-236 734.0
TLS3_k127_4590166_1 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 578.0
TLS3_k127_4590166_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000000362 162.0
TLS3_k127_4590166_3 Cold shock K03704 - - 0.00000000000000000000000000000000001079 138.0
TLS3_k127_4590166_4 C-terminal, D2-small domain, of ClpB protein K03694 - - 0.00000000000001342 73.0
TLS3_k127_4605872_0 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656 - 3.6.4.12 3.215e-198 627.0
TLS3_k127_4605872_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003143 278.0
TLS3_k127_4605872_2 SnoaL-like domain K01822 - 5.3.3.1 0.0000000000000000000000000000000000000000000000004353 179.0
TLS3_k127_4605872_3 cb-type cytochrome c oxidase subunit III - - - 0.0000000000000000000000000000000000000000005035 167.0
TLS3_k127_461037_0 Diguanylate cyclase - - - 1.198e-233 739.0
TLS3_k127_461037_1 TIGRFAM outer membrane adhesin like proteiin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009477 547.0
TLS3_k127_461037_2 COG1538 Outer membrane protein K12543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 497.0
TLS3_k127_461037_3 Malate synthase K01638 - 2.3.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000004555 258.0
TLS3_k127_461037_4 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.0000000000000000000000000000000000000000000000000000000000000000005487 235.0
TLS3_k127_470838_0 Nitrogenase component 1 type Oxidoreductase K02586 - 1.18.6.1 2.404e-297 917.0
TLS3_k127_470838_1 Diguanylate cyclase - - - 3.509e-210 688.0
TLS3_k127_470838_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 546.0
TLS3_k127_470838_3 SIR2-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 432.0
TLS3_k127_470838_4 PFAM Dinitrogenase reductase ADP-ribosyltransferase K05951 - 2.4.2.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 364.0
TLS3_k127_470838_5 This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation K02591 - 1.18.6.1 0.000000001557 60.0
TLS3_k127_472702_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005931 450.0
TLS3_k127_472702_1 B12 binding domain K22491 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 424.0
TLS3_k127_472702_2 AsmA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 436.0
TLS3_k127_472702_3 abc transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005041 381.0
TLS3_k127_472702_4 ROK family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 359.0
TLS3_k127_472702_5 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 317.0
TLS3_k127_472702_6 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000005547 254.0
TLS3_k127_472702_7 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000000000000000000000000000000000003491 217.0
TLS3_k127_4745915_0 Cysteine-rich domain - - - 4.217e-263 814.0
TLS3_k127_4745915_1 Transcriptional regulator K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 386.0
TLS3_k127_4745915_2 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007283 271.0
TLS3_k127_4745915_3 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000662 269.0
TLS3_k127_4745915_4 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002299 263.0
TLS3_k127_4745915_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000000007266 178.0
TLS3_k127_4745915_6 Beta-lactamase - - - 0.0000000000000000000000000000000000000000004084 160.0
TLS3_k127_4745915_7 - - - - 0.00000000007124 66.0
TLS3_k127_4763193_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 2.962e-239 747.0
TLS3_k127_4763193_1 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 2.139e-230 741.0
TLS3_k127_4763193_2 COG0569 K transport systems, NAD-binding component K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 600.0
TLS3_k127_4763193_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 522.0
TLS3_k127_4763193_4 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009015 330.0
TLS3_k127_4763193_5 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000004952 222.0
TLS3_k127_4763193_6 Domain of unknown function (DUF4390) - - - 0.00000000000000000000000000000000000000000000113 171.0
TLS3_k127_4781024_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 382.0
TLS3_k127_4781024_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 321.0
TLS3_k127_4781024_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 289.0
TLS3_k127_4781024_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000005077 242.0
TLS3_k127_4781024_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000007626 133.0
TLS3_k127_480901_0 Belongs to the KdsA family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 471.0
TLS3_k127_480901_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002345 266.0
TLS3_k127_480901_2 Domain of unknown function (DUF1330) - - - 0.000000000000008544 85.0
TLS3_k127_4813019_0 response regulator K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 337.0
TLS3_k127_4813019_1 Histidine kinase K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000009114 249.0
TLS3_k127_4813019_2 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000005056 130.0
TLS3_k127_4817037_0 Asparagine synthase K01953 - 6.3.5.4 8.03e-268 835.0
TLS3_k127_4817037_1 glycolate oxidase iron-sulfur subunit K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 589.0
TLS3_k127_4817037_2 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 417.0
TLS3_k127_4817037_3 phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 295.0
TLS3_k127_4817037_4 deaminase zinc-binding - - - 0.00000000000000000000000000000000000000000000000000002337 201.0
TLS3_k127_4817037_5 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000003821 181.0
TLS3_k127_4817037_6 RDD family - - - 0.000000000000000000000000000000002416 135.0
TLS3_k127_4817037_7 - - - - 0.000000000000002283 78.0
TLS3_k127_4823989_0 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.0 1003.0
TLS3_k127_4823989_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K11959 - - 2.171e-252 781.0
TLS3_k127_4823989_10 Belongs to the urease gamma subunit family K01430 - 3.5.1.5 0.00000000000000000000000000000000000000000000000000005107 187.0
TLS3_k127_4823989_11 Belongs to the urease beta subunit family K01429 - 3.5.1.5 0.00000000000000000000000000000000000000000000004098 170.0
TLS3_k127_4823989_12 May protect the nitrogenase Fe-Mo protein from oxidative damage K02595 - - 0.000000000000000000000000000000000000000005701 156.0
TLS3_k127_4823989_13 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.000000000000005528 82.0
TLS3_k127_4823989_14 Ribosomal protein L7/L12 C-terminal domain - - - 0.00000005646 64.0
TLS3_k127_4823989_2 Belongs to the binding-protein-dependent transport system permease family K11960 - - 3.742e-200 635.0
TLS3_k127_4823989_3 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 603.0
TLS3_k127_4823989_4 Belongs to the binding-protein-dependent transport system permease family K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 584.0
TLS3_k127_4823989_5 Urea ABC transporter ATP-binding protein urtd K11962 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 431.0
TLS3_k127_4823989_6 ABC transporter, ATP-binding protein K11963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 389.0
TLS3_k127_4823989_7 PpiC-type peptidyl-prolyl cis-trans isomerase K01802,K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 357.0
TLS3_k127_4823989_8 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 307.0
TLS3_k127_4823989_9 NifZ domain K02597 - - 0.00000000000000000000000000000000000000000000000000000000000000000004101 234.0
TLS3_k127_4833386_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000001512 154.0
TLS3_k127_4900442_0 PFAM Aminotransferase, class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 562.0
TLS3_k127_4900442_1 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 441.0
TLS3_k127_4900442_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000002424 117.0
TLS3_k127_4900442_11 PFAM PsiF repeat protein - - - 0.000000000000000000001467 97.0
TLS3_k127_4900442_2 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 431.0
TLS3_k127_4900442_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008406 407.0
TLS3_k127_4900442_4 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 K22132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007461 306.0
TLS3_k127_4900442_5 Forkhead associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009121 308.0
TLS3_k127_4900442_6 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002222 245.0
TLS3_k127_4900442_7 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.000000000000000000000000000000000000000000000000000000000000000001057 231.0
TLS3_k127_4900442_8 sigma 54 modulation protein K05808 - - 0.000000000000000000000000000000000000000007459 155.0
TLS3_k127_4900442_9 Major facilitator Superfamily K08218 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600 - 0.000000000000000000000000000000000000001919 148.0
TLS3_k127_4997565_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 410.0
TLS3_k127_4997565_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 310.0
TLS3_k127_4997565_2 COG0530 Ca2 Na antiporter K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000006264 230.0
TLS3_k127_4997565_3 Protein of unknown function (DUF475) K09799 - - 0.00000000000000000000000000000000000000000000000000000000001758 209.0
TLS3_k127_4999954_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 477.0
TLS3_k127_4999954_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 370.0
TLS3_k127_4999954_2 Phosphotransferase system, mannose fructose-specific component IIA K02821 - 2.7.1.194 0.0000000000000000000000000000000000000000000000000003069 197.0
TLS3_k127_4999954_3 Phosphotransferase System K11189 - - 0.00000000000000000000000000000000001552 137.0
TLS3_k127_5063214_0 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 590.0
TLS3_k127_5063214_1 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 393.0
TLS3_k127_5063214_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 352.0
TLS3_k127_5063214_3 phytoene K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 335.0
TLS3_k127_5063214_4 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.000000000000000000000000000000000000000000007776 181.0
TLS3_k127_507385_0 - - - - 0.000000000000000000000000000000000000000000000000000000000598 223.0
TLS3_k127_507385_1 Histidine triad (HIT) - - - 0.0000000000000000000000000000000000000189 147.0
TLS3_k127_507385_2 - - - - 0.00000000000000000000000000000000000002139 151.0
TLS3_k127_5079668_0 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 360.0
TLS3_k127_5079668_1 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000000000000000000000000000000000000000000000002152 226.0
TLS3_k127_5093873_0 COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) K00342 - 1.6.5.3 2.238e-247 771.0
TLS3_k127_5093873_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 503.0
TLS3_k127_5093873_2 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 464.0
TLS3_k127_5104152_1 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000182 178.0
TLS3_k127_5104152_2 Von willebrand factor, type a - - - 0.00000000000002679 72.0
TLS3_k127_5124966_0 TRAP C4-dicarboxylate transport system permease DctM subunit K11690 - - 6.059e-229 713.0
TLS3_k127_5124966_1 Signal transduction histidine kinase K11711 - 2.7.13.3 6.846e-200 648.0
TLS3_k127_5124966_2 )transporter K11688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 478.0
TLS3_k127_5124966_3 Tripartite ATP-independent periplasmic transporters, DctQ component K11689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 381.0
TLS3_k127_5173034_0 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 535.0
TLS3_k127_5173034_1 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 474.0
TLS3_k127_5173034_2 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 304.0
TLS3_k127_5173034_3 ankyrin repeat K15503 - - 0.0000000002673 68.0
TLS3_k127_5176104_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0 1017.0
TLS3_k127_5176104_1 Protein of unknown function, DUF255 K06888 - - 9.85e-222 703.0
TLS3_k127_5176104_2 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 318.0
TLS3_k127_5176104_3 - - - - 0.0000000000000000000000000000000000000000002821 168.0
TLS3_k127_5176104_4 - - - - 0.00000000000000000000000000000000000000000697 166.0
TLS3_k127_5176104_5 Cytochrome c K08738 - - 0.000000000000000000000000002673 115.0
TLS3_k127_5176104_6 Domain of unknown function (DUF4124) - - - 0.0003549 51.0
TLS3_k127_5176520_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004214 595.0
TLS3_k127_5176520_1 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 295.0
TLS3_k127_5176520_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000006782 194.0
TLS3_k127_5184459_0 COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) K00336 - 1.6.5.3 0.0 1037.0
TLS3_k127_5184459_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 4.905e-246 763.0
TLS3_k127_5184459_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 291.0
TLS3_k127_5184459_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009316 282.0
TLS3_k127_5184459_12 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000007336 257.0
TLS3_k127_5184459_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000005425 209.0
TLS3_k127_5184459_14 preprotein translocase K03075 - - 0.00000000000000000000000000000000000000002163 155.0
TLS3_k127_5184459_15 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000006837 143.0
TLS3_k127_5184459_16 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000292 138.0
TLS3_k127_5184459_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 4.417e-238 741.0
TLS3_k127_5184459_3 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006201 559.0
TLS3_k127_5184459_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009914 525.0
TLS3_k127_5184459_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 513.0
TLS3_k127_5184459_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003395 448.0
TLS3_k127_5184459_7 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 426.0
TLS3_k127_5184459_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 336.0
TLS3_k127_5184459_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 316.0
TLS3_k127_5184596_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 3.667e-257 807.0
TLS3_k127_5184596_1 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000002292 204.0
TLS3_k127_5188282_0 chemotaxis K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 403.0
TLS3_k127_5188282_1 LigT like Phosphoesterase - - - 0.0000000000000000000000000000000000000003173 157.0
TLS3_k127_5188282_2 Cytochrome c554 and c-prime - - - 0.00000006275 57.0
TLS3_k127_5194637_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 3.931e-197 618.0
TLS3_k127_5194637_1 Ferric reductase like transmembrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 560.0
TLS3_k127_5194637_2 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000001863 218.0
TLS3_k127_5194637_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000000000000001272 166.0
TLS3_k127_5198709_0 Sulfate transporter antisigma-factor antagonist STAS - - - 5.499e-290 915.0
TLS3_k127_5198709_1 Citrate transporter - - - 1.445e-264 835.0
TLS3_k127_5198709_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007355 524.0
TLS3_k127_5198709_3 Proton-conducting membrane transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 383.0
TLS3_k127_5198709_4 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009092 348.0
TLS3_k127_5224728_0 Type II secretion system K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004859 354.0
TLS3_k127_5224728_1 PFAM type II secretion system K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 351.0
TLS3_k127_5224728_2 PFAM TadE family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000004919 240.0
TLS3_k127_5224728_3 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000003536 90.0
TLS3_k127_5224728_4 - - - - 0.000009879 56.0
TLS3_k127_5253927_0 Outer membrane receptor - - - 0.0 1178.0
TLS3_k127_5253927_1 Subtilase family - - - 2.731e-222 700.0
TLS3_k127_5253927_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 456.0
TLS3_k127_5253927_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007184 337.0
TLS3_k127_5253927_4 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000000000000000000000000000000000000000000000009246 185.0
TLS3_k127_5253927_5 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000002894 186.0
TLS3_k127_5253927_6 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis K01494 - 3.5.4.13 0.000000000000000000000000000000002688 129.0
TLS3_k127_5260349_0 RecB family exonuclease K01144 - 3.1.11.5 8.083e-232 745.0
TLS3_k127_5260349_1 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 470.0
TLS3_k127_5260349_10 - - - - 0.000000000000000000000001879 113.0
TLS3_k127_5260349_11 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.00000000000003811 78.0
TLS3_k127_5260349_2 DNA polymerase III K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 462.0
TLS3_k127_5260349_3 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 436.0
TLS3_k127_5260349_4 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 431.0
TLS3_k127_5260349_5 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 307.0
TLS3_k127_5260349_6 ferredoxin--nadp reductase K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 301.0
TLS3_k127_5260349_7 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000000000000004622 194.0
TLS3_k127_5260349_8 - - - - 0.000000000000000000000000000000001675 139.0
TLS3_k127_5260349_9 DsrC like protein K11179 - - 0.000000000000000000000000005157 115.0
TLS3_k127_5266807_0 cyclic-guanylate-specific phosphodiesterase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 521.0
TLS3_k127_5266807_1 Transcriptional regulator K07722 - - 0.00000000000000000000000000000000000000000000000000000000000000001651 227.0
TLS3_k127_5266807_2 - - - - 0.000000000000000001031 90.0
TLS3_k127_5266807_3 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000009021 76.0
TLS3_k127_5268421_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 326.0
TLS3_k127_5268421_1 type II secretion system protein K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000001975 227.0
TLS3_k127_5268421_2 - - - - 0.00000000000000000000000000000008724 136.0
TLS3_k127_5286770_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009281 543.0
TLS3_k127_5286770_1 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000008316 206.0
TLS3_k127_5286770_2 EamA-like transporter family - - - 0.00000000000000000000000000000000002472 138.0
TLS3_k127_5324616_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 7.996e-239 745.0
TLS3_k127_5324616_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 318.0
TLS3_k127_5324616_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000002485 251.0
TLS3_k127_5324616_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000001469 144.0
TLS3_k127_5324616_4 - - - - 0.0000000000000000000000000008108 121.0
TLS3_k127_5342307_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K12276 - - 1.031e-260 811.0
TLS3_k127_5342307_1 Type II secretion system (T2SS), protein F K02455,K12278 - - 0.0000000000000000000000000000002895 128.0
TLS3_k127_5362248_0 glutamate synthase, alpha subunit domain protein K00265 - 1.4.1.13,1.4.1.14 0.0 2298.0
TLS3_k127_5362248_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.221e-261 818.0
TLS3_k127_5362248_2 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 6.526e-260 807.0
TLS3_k127_5362248_3 COG0480 Translation elongation factors (GTPases) K02355 - - 2.888e-241 753.0
TLS3_k127_5362248_4 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 1.017e-195 619.0
TLS3_k127_5366802_0 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 593.0
TLS3_k127_5366802_1 Peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 580.0
TLS3_k127_5366802_2 Peptidase family U32 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007287 369.0
TLS3_k127_5366802_3 hydrolase of the alpha beta superfamily K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000372 268.0
TLS3_k127_5366802_4 VanZ like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007849 268.0
TLS3_k127_5366802_5 lipid carrier protein - - - 0.000000000000000000000000000000000000000000001031 181.0
TLS3_k127_5366802_6 Ferredoxin - - - 0.00000000000000000000000000000000000000000001252 164.0
TLS3_k127_5366802_7 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.000000000000000000000000000000000000434 150.0
TLS3_k127_5366802_8 Nucleotide pyrophosphohydrolase - - - 0.000000000000000000000000000000000001248 141.0
TLS3_k127_5371101_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01908 - 6.2.1.17 0.0 1110.0
TLS3_k127_5371101_1 Cytochrome C and Quinol oxidase polypeptide I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 523.0
TLS3_k127_5371101_2 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 514.0
TLS3_k127_5371101_3 SCO1/SenC K07152 - - 0.00000000000000000000000000000000005768 143.0
TLS3_k127_5371101_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000003241 125.0
TLS3_k127_5371101_5 response regulator K21020 - 2.7.7.65 0.00000000000204 76.0
TLS3_k127_5372333_0 Dehydrogenase E1 component K00164 - 1.2.4.2 0.0 1440.0
TLS3_k127_5372333_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.755e-274 855.0
TLS3_k127_5372333_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 1.188e-228 715.0
TLS3_k127_5372333_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 581.0
TLS3_k127_5372333_4 AFG1-like ATPase K06916 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 490.0
TLS3_k127_5372333_5 FKBP-type peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000003637 242.0
TLS3_k127_5372333_6 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000001186 219.0
TLS3_k127_5379993_0 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 509.0
TLS3_k127_5379993_1 Bacterial periplasmic substrate-binding proteins K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004561 467.0
TLS3_k127_5379993_2 ABC-type polar amino acid transport system, ATPase component K10004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 421.0
TLS3_k127_5379993_3 amino acid transport K02029,K10003,K10040 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 396.0
TLS3_k127_5379993_4 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K10002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006905 369.0
TLS3_k127_5379993_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 318.0
TLS3_k127_5379993_6 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000000000000000000000000006236 218.0
TLS3_k127_538799_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 359.0
TLS3_k127_538799_1 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001143 273.0
TLS3_k127_538799_2 - - - - 0.000000000000000000000000003485 116.0
TLS3_k127_538799_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0000000000000001327 78.0
TLS3_k127_5417392_0 DJ-1/PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 334.0
TLS3_k127_5417392_1 Ribbon-helix-helix domain - - - 0.00000000000000000000000000000000000000001728 156.0
TLS3_k127_5417392_2 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.0000000000000002497 79.0
TLS3_k127_5417392_3 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000001712 65.0
TLS3_k127_5418256_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 440.0
TLS3_k127_5418256_1 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 407.0
TLS3_k127_5418256_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000000000000000000000006898 235.0
TLS3_k127_5418256_3 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.00000000000000000000000000000000000000000000106 173.0
TLS3_k127_5418256_4 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000000000000000000000000002082 168.0
TLS3_k127_5418256_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000000000006914 108.0
TLS3_k127_5425542_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1018.0
TLS3_k127_5425542_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 514.0
TLS3_k127_5425542_10 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000007402 230.0
TLS3_k127_5425542_11 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000000000000000000000002652 223.0
TLS3_k127_5425542_12 Belongs to the skp family K06142 - - 0.0000000000000000000000000000000000000000000000000000009822 197.0
TLS3_k127_5425542_13 PFAM TonB-dependent receptor plug K02014 - - 0.0000000000000000000000000000000006742 136.0
TLS3_k127_5425542_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 502.0
TLS3_k127_5425542_3 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 503.0
TLS3_k127_5425542_4 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 392.0
TLS3_k127_5425542_5 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 391.0
TLS3_k127_5425542_6 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 372.0
TLS3_k127_5425542_7 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001096 280.0
TLS3_k127_5425542_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000009176 248.0
TLS3_k127_5425542_9 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000001059 236.0
TLS3_k127_5452929_0 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 585.0
TLS3_k127_5452929_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 584.0
TLS3_k127_5452929_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.00000000000000000000000000000002985 132.0
TLS3_k127_5452929_11 TonB dependent receptor K02014 - - 0.000000000000001885 81.0
TLS3_k127_5452929_2 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 585.0
TLS3_k127_5452929_3 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 498.0
TLS3_k127_5452929_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 494.0
TLS3_k127_5452929_5 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 436.0
TLS3_k127_5452929_6 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 349.0
TLS3_k127_5452929_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 349.0
TLS3_k127_5452929_8 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000000007481 223.0
TLS3_k127_5452929_9 cheY-homologous receiver domain K02485 - - 0.0000000000000000000000000000000000000000000000000000003611 198.0
TLS3_k127_5483485_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.031e-209 655.0
TLS3_k127_5483485_1 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 381.0
TLS3_k127_5483485_2 diguanylate cyclase K13590 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 326.0
TLS3_k127_5483485_3 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 317.0
TLS3_k127_5483485_4 PFAM cytochrome B561 K12262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001093 286.0
TLS3_k127_5483485_5 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000003436 212.0
TLS3_k127_5483485_6 - - - - 0.00000000000001422 78.0
TLS3_k127_5484056_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.215e-230 719.0
TLS3_k127_5484056_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 6.991e-210 658.0
TLS3_k127_5484056_10 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001279 250.0
TLS3_k127_5484056_11 Tripartite ATP-independent periplasmic transporter, DctM component K11690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007749 246.0
TLS3_k127_5484056_12 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000003531 235.0
TLS3_k127_5484056_13 type 4 pilus biogenesis protein K02656 - - 0.0000000000000000000000000000000000000000000000000000000000216 219.0
TLS3_k127_5484056_14 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000003625 188.0
TLS3_k127_5484056_15 Domain of unknown function (DUF4115) K15539 - - 0.00000000000000000000000000000000000003598 154.0
TLS3_k127_5484056_16 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000004276 149.0
TLS3_k127_5484056_17 protein conserved in bacteria K09937 - - 0.000000000000000001471 90.0
TLS3_k127_5484056_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 3.18e-198 624.0
TLS3_k127_5484056_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 9.686e-198 624.0
TLS3_k127_5484056_4 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 589.0
TLS3_k127_5484056_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 567.0
TLS3_k127_5484056_6 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 524.0
TLS3_k127_5484056_7 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 494.0
TLS3_k127_5484056_8 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007763 467.0
TLS3_k127_5484056_9 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008902 403.0
TLS3_k127_5523089_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 3.47e-210 664.0
TLS3_k127_5523089_1 peptidase, M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004773 268.0
TLS3_k127_5523089_2 - - - - 0.000000000000000000000000000000000000000004846 160.0
TLS3_k127_5523089_3 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000002057 128.0
TLS3_k127_5538671_0 formate dehydrogenase K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 547.0
TLS3_k127_5538671_1 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005927 400.0
TLS3_k127_5538671_2 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000002488 189.0
TLS3_k127_5544018_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 404.0
TLS3_k127_5544018_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 351.0
TLS3_k127_5544018_2 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000002603 63.0
TLS3_k127_5555471_0 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004962 246.0
TLS3_k127_5555471_1 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000496 228.0
TLS3_k127_5555471_2 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000003299 121.0
TLS3_k127_5555471_3 Belongs to the UPF0312 family - - - 0.000000000000000007193 83.0
TLS3_k127_5555471_4 Metal-dependent hydrolase K07043 - - 0.00000000916 63.0
TLS3_k127_55868_0 Tex-like protein N-terminal domain K06959 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - 1.303e-275 855.0
TLS3_k127_55868_1 Belongs to the ArsC family K00537 - 1.20.4.1 0.000000000000000000000000000003988 121.0
TLS3_k127_5636598_0 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 7.973e-221 693.0
TLS3_k127_5636598_1 deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 577.0
TLS3_k127_5636598_2 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 521.0
TLS3_k127_5636598_3 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000001183 214.0
TLS3_k127_5636598_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000000000000000000000000005266 191.0
TLS3_k127_5636598_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.00000000000000000000000008037 117.0
TLS3_k127_5642100_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 9.668e-317 981.0
TLS3_k127_5642100_1 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000000000000003643 198.0
TLS3_k127_5642900_0 NifU-like domain K13819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 316.0
TLS3_k127_5642900_1 Domains Cache_1, HAMP, PAS, PAS K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 323.0
TLS3_k127_5642900_2 V4R K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005961 264.0
TLS3_k127_5642900_3 Iron-sulphur cluster biosynthesis - - - 0.0000000000000000000000000000000000002964 143.0
TLS3_k127_5642900_4 - - - - 0.0000000000000000002219 89.0
TLS3_k127_5694111_0 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 540.0
TLS3_k127_5694111_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 412.0
TLS3_k127_5698859_0 Aspartate ammonia-lyase K01744 - 4.3.1.1 2.596e-234 731.0
TLS3_k127_5698859_1 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007915 559.0
TLS3_k127_5698859_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 336.0
TLS3_k127_5698859_3 epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 304.0
TLS3_k127_5698859_4 methionine biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 285.0
TLS3_k127_5698859_5 Soluble lytic murein transglycosylase L domain K08309 - - 0.0000000000000000000000000000000000000000000000000000000000009735 212.0
TLS3_k127_5705967_0 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 426.0
TLS3_k127_5705967_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 415.0
TLS3_k127_5705967_2 protein containing LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 326.0
TLS3_k127_5705967_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000001194 249.0
TLS3_k127_5705967_4 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000002647 233.0
TLS3_k127_5705967_5 Belongs to the Smg family K03747 - - 0.000000000000000000000000000000000007963 152.0
TLS3_k127_5705967_6 DNA topoisomerase III K03169 - 5.99.1.2 0.00009551 44.0
TLS3_k127_5736770_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 373.0
TLS3_k127_5736770_1 Belongs to the MtfA family K09933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 319.0
TLS3_k127_5736770_2 peptidylprolyl isomerase K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 301.0
TLS3_k127_5736770_3 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000008115 241.0
TLS3_k127_5736770_4 Phage derived protein Gp49-like (DUF891) - - - 0.00000000000000000000000000000000000000000005726 162.0
TLS3_k127_5736770_5 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000001423 155.0
TLS3_k127_5736770_6 BolA-like protein K05527 - - 0.0000000000003999 70.0
TLS3_k127_5759434_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 394.0
TLS3_k127_5759434_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 367.0
TLS3_k127_5759434_2 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000001228 233.0
TLS3_k127_5759434_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000007228 233.0
TLS3_k127_5759434_4 PAS fold - - - 0.00000000000000000000000000000000000000000001154 186.0
TLS3_k127_5759434_5 response regulator - - - 0.000000000000000000000000008117 128.0
TLS3_k127_5815222_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 5.974e-194 608.0
TLS3_k127_5815222_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 359.0
TLS3_k127_5815222_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 353.0
TLS3_k127_5880761_0 COG0643 Chemotaxis protein histidine kinase and related kinases K03407 - 2.7.13.3 3.635e-288 896.0
TLS3_k127_5880761_1 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 411.0
TLS3_k127_5880761_2 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) K03414 - - 0.000000000000000007963 83.0
TLS3_k127_5905794_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 5.228e-219 687.0
TLS3_k127_5905794_1 TIGRFAM fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 591.0
TLS3_k127_5905794_2 Hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009604 374.0
TLS3_k127_5905794_3 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 346.0
TLS3_k127_5905794_4 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006811 368.0
TLS3_k127_5905794_5 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000007328 263.0
TLS3_k127_5956534_0 Chromate transporter K07240 - - 1.86e-198 624.0
TLS3_k127_5956534_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000005016 221.0
TLS3_k127_5956534_2 - - - - 0.000000000000000000000008783 108.0
TLS3_k127_596187_0 Sel1-like repeats. K07126 - - 0.00000000000000000000000000000000000000000000000000000000000004188 235.0
TLS3_k127_596187_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000003354 115.0
TLS3_k127_5989509_0 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000937 364.0
TLS3_k127_5989509_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 306.0
TLS3_k127_5989509_2 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000000000000000000000000001491 229.0
TLS3_k127_5989509_3 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000001503 230.0
TLS3_k127_5989509_4 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000001909 130.0
TLS3_k127_5989509_5 Predicted membrane protein (DUF2069) - - - 0.00000000007109 64.0
TLS3_k127_6022047_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 3.069e-238 741.0
TLS3_k127_6022047_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 611.0
TLS3_k127_6022047_2 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 550.0
TLS3_k127_6022047_3 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 549.0
TLS3_k127_6022047_4 pfkB family carbohydrate kinase K21344 - 2.7.1.167 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 439.0
TLS3_k127_6022047_5 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.00000000000000000000000000000000000000000000005899 170.0
TLS3_k127_6022047_6 Pfam:DUF1049 K08992 - - 0.0000000000000001079 83.0
TLS3_k127_6041177_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 2.572e-233 728.0
TLS3_k127_6041177_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000004753 226.0
TLS3_k127_6045261_0 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 497.0
TLS3_k127_6045261_1 RnfC Barrel sandwich hybrid domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 343.0
TLS3_k127_6045261_2 Part of a membrane complex involved in electron transport K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 329.0
TLS3_k127_6045261_3 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006137 323.0
TLS3_k127_6045261_4 protein conserved in bacteria K09928 - - 0.0000000000000000000000000000000000000000000000000000000101 201.0
TLS3_k127_6050623_0 Transcriptional regulator with HTH domain and aminotransferase domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 567.0
TLS3_k127_6050623_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 542.0
TLS3_k127_6050623_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003664 442.0
TLS3_k127_6050623_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 344.0
TLS3_k127_6050623_4 A G-specific K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 335.0
TLS3_k127_6050623_5 COG2104 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.0000000000000000003568 92.0
TLS3_k127_6050623_7 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.00000000008871 64.0
TLS3_k127_6056644_0 Mate efflux family protein K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 430.0
TLS3_k127_6056644_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006691 404.0
TLS3_k127_6056644_2 Domain of unknown function (DUF3400) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 374.0
TLS3_k127_6056644_3 Proton-conducting membrane transporter K05568 - - 0.0000000000000000000000000000000000000000000000000000000000009571 215.0
TLS3_k127_6062921_0 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 1.256e-195 614.0
TLS3_k127_6062921_1 LysR substrate binding domain K21703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 327.0
TLS3_k127_6062921_2 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 313.0
TLS3_k127_6068280_0 Uncharacterized protein family UPF0004 K06168 - 2.8.4.3 7.088e-214 677.0
TLS3_k127_6068280_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 490.0
TLS3_k127_6068280_10 - - - - 0.00000005773 62.0
TLS3_k127_6068280_2 phosphate starvation-inducible protein PhoH K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 481.0
TLS3_k127_6068280_3 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 469.0
TLS3_k127_6068280_4 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 417.0
TLS3_k127_6068280_5 Mg2 and Co2 transporter CorC K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 394.0
TLS3_k127_6068280_6 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 361.0
TLS3_k127_6068280_7 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 374.0
TLS3_k127_6068280_8 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000000000000000002701 191.0
TLS3_k127_6068280_9 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000002294 58.0
TLS3_k127_6075702_0 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0 1049.0
TLS3_k127_6075702_1 FAD-dependent pyridine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004944 534.0
TLS3_k127_6075702_2 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000406 281.0
TLS3_k127_6075702_3 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003163 260.0
TLS3_k127_6075702_4 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000004744 211.0
TLS3_k127_6075702_5 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000004546 160.0
TLS3_k127_6075702_6 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.00000000000000000000000000004788 118.0
TLS3_k127_6075702_7 Mut7-C ubiquitin - - - 0.00000000000000000000000002374 113.0
TLS3_k127_6075702_9 - - - - 0.0002564 48.0
TLS3_k127_6077284_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 504.0
TLS3_k127_6077284_1 GTP-binding protein TypA K06207 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003776 408.0
TLS3_k127_6077284_2 phosphoribosyltransferase K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000005852 228.0
TLS3_k127_6077284_3 (Lipo)protein - - - 0.00000000000000000000000000000000000000000000000143 185.0
TLS3_k127_6077284_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.0000000003779 60.0
TLS3_k127_6078125_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0 1045.0
TLS3_k127_6078125_1 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 535.0
TLS3_k127_6078125_2 ATP ADP translocase K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003863 279.0
TLS3_k127_6078125_3 - - - - 0.000000000000000000000000000000000000000000000001928 177.0
TLS3_k127_6078125_4 - - - - 0.000000000001077 74.0
TLS3_k127_6085807_0 Mg chelatase subunit ChlI K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 524.0
TLS3_k127_6085807_1 Drug resistance transporter Bcr CflA subfamily K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001814 261.0
TLS3_k127_6110461_0 chorismate binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 399.0
TLS3_k127_6110461_1 DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.0000000000000007109 91.0
TLS3_k127_6112989_0 Cysteine-rich domain - - - 4.55e-222 695.0
TLS3_k127_6112989_1 Nitrite and sulphite reductase 4Fe-4S domain K11181 - 1.8.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 487.0
TLS3_k127_6112989_2 Nitrate reductase gamma subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 336.0
TLS3_k127_6112989_3 TIGRFAM sulfur relay protein TusD DsrE K07235 GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0019417,GO:0044237,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000005715 235.0
TLS3_k127_6112989_4 DsrC like protein K11179 - - 0.000000000000000000000000000000000000000000000000000001142 194.0
TLS3_k127_6112989_5 DsrE/DsrF-like family K07236 - - 0.0000000000000000000000000000000000000000000000000003493 187.0
TLS3_k127_6112989_6 DsrH like protein K07237 - - 0.00000000000000000000000000000001432 129.0
TLS3_k127_6116456_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 393.0
TLS3_k127_6116456_1 Polysaccharide pyruvyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 310.0
TLS3_k127_6116456_2 NADP oxidoreductase, coenzyme f420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000212 131.0
TLS3_k127_6125564_0 MMPL family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 475.0
TLS3_k127_6125564_1 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 431.0
TLS3_k127_6125564_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000007603 208.0
TLS3_k127_6132357_0 ABC transporter transmembrane region K12541 - - 0.0 1019.0
TLS3_k127_6132357_1 HlyD family secretion protein K12542 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 593.0
TLS3_k127_6132357_2 Flavocytochrome c sulphide dehydrogenase, flavin-binding K17218,K17229 - 1.8.2.3,1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 471.0
TLS3_k127_6132357_3 Ethylbenzene dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006178 280.0
TLS3_k127_6132357_4 Mediates electron flow from quinones to the NapAB complex K02569 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0055114,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000001143 204.0
TLS3_k127_6132357_5 PFAM Cytochrome C K17230 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000006598 173.0
TLS3_k127_6132357_6 luxR family - - - 0.0000000000000000000000000000000000000000011 163.0
TLS3_k127_6132357_7 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000000006436 130.0
TLS3_k127_6134694_0 regulatory protein LysR - - - 0.0000000000000000000000000000000000000000000000000000000000000000005391 241.0
TLS3_k127_6134694_1 PFAM extracellular solute-binding protein family 1 K05772 - - 0.000000000000000003918 88.0
TLS3_k127_6134694_2 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.000000001681 59.0
TLS3_k127_6140065_0 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 2.968e-242 775.0
TLS3_k127_6140065_1 Cytochrome c3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 507.0
TLS3_k127_6140065_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000227 85.0
TLS3_k127_6140065_3 AraC-binding-like domain - - - 0.0000000002227 61.0
TLS3_k127_6143486_0 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-17-dioic acid hydratase (catechol pathway) K16165 - 3.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 295.0
TLS3_k127_6143486_1 Acyl carrier protein phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005381 274.0
TLS3_k127_6143486_2 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007001 252.0
TLS3_k127_6143486_4 - - - - 0.000000000000000000000000000833 113.0
TLS3_k127_6143486_5 Diguanylate cyclase - - - 0.0000000000000000000000119 108.0
TLS3_k127_6144193_0 ABC transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 455.0
TLS3_k127_6144193_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000103 234.0
TLS3_k127_6144193_3 Aconitate B N-terminal domain K01682 - 4.2.1.3,4.2.1.99 0.000000000000000000000000000000000000000002516 156.0
TLS3_k127_6144193_4 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000000000000000000005437 141.0
TLS3_k127_6144193_5 TonB C terminal - - - 0.0000000000000000000000000000000001146 153.0
TLS3_k127_6167273_0 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0 1030.0
TLS3_k127_6167273_1 Histidine kinase K05962 - 2.7.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008398 459.0
TLS3_k127_6167273_10 EF hand - - - 0.0000000000171 71.0
TLS3_k127_6167273_2 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 383.0
TLS3_k127_6167273_3 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 331.0
TLS3_k127_6167273_4 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 312.0
TLS3_k127_6167273_5 MlaC protein K07323 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003427 245.0
TLS3_k127_6167273_6 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000003443 223.0
TLS3_k127_6167273_7 - - - - 0.000000000000000000000000000000000000000001234 163.0
TLS3_k127_6167273_8 Pfam Response regulator receiver - - - 0.000000000000000000000000000000002402 134.0
TLS3_k127_6167273_9 bacterial OsmY and nodulation domain - - - 0.000000000000000000000000000004248 122.0
TLS3_k127_6167564_0 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 381.0
TLS3_k127_6167564_1 PFAM cytochrome c - - - 0.000000000000000000000000000000000000002526 155.0
TLS3_k127_6167564_2 protein required for cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000002828 126.0
TLS3_k127_6167564_3 cytochrome c oxidase, subunit III K02276 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 0.0000000003735 64.0
TLS3_k127_6168914_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 1.17e-208 657.0
TLS3_k127_6168914_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 401.0
TLS3_k127_6176638_0 TIGRFAM para-aminobenzoate synthase, subunit I K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 361.0
TLS3_k127_6176638_1 cell redox homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002353 276.0
TLS3_k127_6176638_2 DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000003007 280.0
TLS3_k127_6178753_0 Glucose / Sorbosone dehydrogenase - - - 3.611e-235 740.0
TLS3_k127_6178753_1 Two-component sensor kinase N-terminal K02484,K07645 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000009441 211.0
TLS3_k127_6178753_2 Cytochrome c - - - 0.000000000000000000000000009619 112.0
TLS3_k127_6178753_3 OpgC protein - - - 0.000000000000000001779 87.0
TLS3_k127_6185447_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 508.0
TLS3_k127_6185447_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 369.0
TLS3_k127_6185447_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 360.0
TLS3_k127_6185447_3 threonine efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006983 277.0
TLS3_k127_6185447_4 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.0000000000000000000000000000000000000000000000002716 181.0
TLS3_k127_6195391_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005087 599.0
TLS3_k127_6195391_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001541 250.0
TLS3_k127_6195391_2 - - - - 0.00000000000000262 78.0
TLS3_k127_620591_0 Flavin containing amine oxidoreductase - - - 6.731e-235 733.0
TLS3_k127_620591_1 Cyclopropane fatty acid synthase K00574 - 2.1.1.79 1.764e-197 634.0
TLS3_k127_620591_2 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 371.0
TLS3_k127_620591_3 Chalcone isomerase-like - - - 0.000000000000000000000000000000000000000000000000719 180.0
TLS3_k127_6239478_0 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 1.756e-203 652.0
TLS3_k127_6239478_1 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 350.0
TLS3_k127_6239478_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000001357 221.0
TLS3_k127_6239478_3 protein involved in tolerance to divalent cations K03926 - - 0.00000000000000000000000000000000000000000349 156.0
TLS3_k127_6255062_0 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 4.834e-291 903.0
TLS3_k127_6255062_1 Hydroxymethylglutaryl-CoA lyase K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 422.0
TLS3_k127_6255062_2 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 378.0
TLS3_k127_6255062_3 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000000000000000000000000000009554 142.0
TLS3_k127_6274773_0 COG0643 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 0.0 1214.0
TLS3_k127_6274773_1 Acts as a magnesium transporter K06213 - - 5.613e-227 711.0
TLS3_k127_6274773_10 Chemotaxis signal transduction protein K02659 - - 0.00000000000000000000000000000000000000000000000000000005184 202.0
TLS3_k127_6274773_11 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000005211 206.0
TLS3_k127_6274773_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000007316 197.0
TLS3_k127_6274773_13 response regulator receiver K02658 - - 0.0000000000000000000000000000000000000000000000000001294 188.0
TLS3_k127_6274773_2 Aminotransferase K01845 - 5.4.3.8 5.092e-202 642.0
TLS3_k127_6274773_3 Methyl-accepting chemotaxis protein K02660 - - 4.535e-200 645.0
TLS3_k127_6274773_4 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 414.0
TLS3_k127_6274773_5 RNB K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 386.0
TLS3_k127_6274773_6 TonB family K03832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 321.0
TLS3_k127_6274773_7 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 316.0
TLS3_k127_6274773_8 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 293.0
TLS3_k127_6274773_9 RESPONSE REGULATOR receiver K02657 - - 0.000000000000000000000000000000000000000000000000000000000000007502 218.0
TLS3_k127_6290798_0 transposase IS66 - - - 2.245e-199 634.0
TLS3_k127_6290798_1 - - - - 0.0000000000000000000000000000000000000000000000000000000004243 207.0
TLS3_k127_6290798_2 PFAM IS66 Orf2 family protein K07484 - - 0.0000000000000000000000000000000000000000000000001434 178.0
TLS3_k127_6290798_3 COG3436 Transposase and inactivated derivatives K07484 - - 0.0000000000000000000000004825 106.0
TLS3_k127_6290798_4 Helix-turn-helix domain of transposase family ISL3 K07483 - - 0.00000000000000000000000343 106.0
TLS3_k127_6290798_5 regulator - - - 0.000000000001772 68.0
TLS3_k127_6308292_0 SMART zinc finger, CDGSH-type domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 301.0
TLS3_k127_6308292_1 Dioxygenase K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 297.0
TLS3_k127_6308292_2 - - - - 0.0000000000001351 73.0
TLS3_k127_6308292_3 Predicted integral membrane protein (DUF2189) - - - 0.00000000000122 69.0
TLS3_k127_6336355_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.997e-291 902.0
TLS3_k127_6336355_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 441.0
TLS3_k127_6367835_0 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 620.0
TLS3_k127_6367835_1 Belongs to the UPF0307 family K09889 - - 0.000000000000000000000000000000000000000000000000000625 189.0
TLS3_k127_6367835_2 Molybdenum cofactor biosynthesis protein K03831 - 2.7.7.75 0.00000000000000000000000000000000000003889 149.0
TLS3_k127_6367835_3 Transcriptional regulator - - - 0.0000000000000000000003934 99.0
TLS3_k127_6394031_0 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 3.194e-316 974.0
TLS3_k127_6394031_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 3.08e-252 784.0
TLS3_k127_6394031_10 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001041 273.0
TLS3_k127_6394031_11 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.000000000000000000000000000000000000006081 164.0
TLS3_k127_6394031_12 membrane protein domain - - - 0.000000000000000000000000000001453 126.0
TLS3_k127_6394031_13 Protein of unknown function (DUF3106) - - - 0.000000000000000000000000000002894 124.0
TLS3_k127_6394031_14 Protein of unknown function (DUF3619) - - - 0.00000000000009453 79.0
TLS3_k127_6394031_2 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 1.905e-212 663.0
TLS3_k127_6394031_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 2.855e-199 623.0
TLS3_k127_6394031_4 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 558.0
TLS3_k127_6394031_5 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 550.0
TLS3_k127_6394031_6 Predicted permease YjgP/YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 447.0
TLS3_k127_6394031_7 Permease YjgP YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000514 424.0
TLS3_k127_6394031_8 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 339.0
TLS3_k127_6394031_9 Acetolactate synthase small K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006765 282.0
TLS3_k127_6426806_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 526.0
TLS3_k127_6426806_1 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 366.0
TLS3_k127_6426806_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000001842 231.0
TLS3_k127_6463670_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.551e-227 711.0
TLS3_k127_6463670_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 518.0
TLS3_k127_6463670_2 fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 433.0
TLS3_k127_6463670_3 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000129 73.0
TLS3_k127_6463670_4 E1 component K00164 - 1.2.4.2 0.0000000000006892 71.0
TLS3_k127_6471373_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 4.908e-230 722.0
TLS3_k127_6471373_1 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008305 440.0
TLS3_k127_6471373_2 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 333.0
TLS3_k127_6471373_3 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000000000000000000000000000000000000000000001881 170.0
TLS3_k127_6475442_0 divalent heavy-metal cations transporter K07238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 454.0
TLS3_k127_6475442_1 pdz dhr glgf - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 312.0
TLS3_k127_6475442_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001507 274.0
TLS3_k127_6475442_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000008919 172.0
TLS3_k127_6475442_4 - - - - 0.00000000000000000000000000000000000005788 146.0
TLS3_k127_6475442_5 membrane - - - 0.000000000000000001084 99.0
TLS3_k127_652331_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 517.0
TLS3_k127_652331_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000932 387.0
TLS3_k127_652331_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 338.0
TLS3_k127_652331_3 Ribosomal L25p family K02897 - - 0.00000000000000000000000000000000000000000000000000000004667 199.0
TLS3_k127_652331_4 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.000000000000000000000002577 109.0
TLS3_k127_6533401_0 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 387.0
TLS3_k127_6533401_1 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000000000000000000000004025 215.0
TLS3_k127_6533734_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007607 605.0
TLS3_k127_6533734_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 453.0
TLS3_k127_6533734_2 Nad-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 408.0
TLS3_k127_6533734_3 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007326 405.0
TLS3_k127_6533734_4 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003849 286.0
TLS3_k127_6533734_5 integral membrane protein - - - 0.0000000000000000000000000000000857 143.0
TLS3_k127_6540705_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 507.0
TLS3_k127_6540705_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 445.0
TLS3_k127_6540705_2 electron transport coupled proton transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006641 376.0
TLS3_k127_6540705_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008392 362.0
TLS3_k127_6540705_4 Integral membrane protein (DUF2244) - - - 0.0000000000000005639 85.0
TLS3_k127_6540705_5 Polymer-forming cytoskeletal - - - 0.00000000000001295 85.0
TLS3_k127_6549581_0 PFAM PilT protein domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002864 233.0
TLS3_k127_6549581_1 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000318 218.0
TLS3_k127_6549581_2 Transcriptional regulator K19591,K21744 - - 0.00000000000000000000000000000000000000000000000000000000001045 219.0
TLS3_k127_6549581_3 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000009426 183.0
TLS3_k127_6549581_4 prlF antitoxin for toxin YhaV_toxin - - - 0.0000000000000000000000000000000004524 132.0
TLS3_k127_6549581_5 - - - - 0.0000000000000000000000000000002815 126.0
TLS3_k127_6641057_0 Putative diguanylate phosphodiesterase - - - 1.046e-293 923.0
TLS3_k127_6641057_1 associated with various cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 537.0
TLS3_k127_6641057_2 2Fe-2S iron-sulfur cluster binding domain K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 491.0
TLS3_k127_6641057_3 FIST_C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 364.0
TLS3_k127_6641057_4 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000003966 199.0
TLS3_k127_6641057_5 Peptidase S24-like - - - 0.000000000000000000000000000000001777 134.0
TLS3_k127_6641057_6 - - - - 0.00000000000000000000000000003179 121.0
TLS3_k127_6641057_7 Permeases of the major facilitator superfamily - - - 0.000000000000000000000001114 104.0
TLS3_k127_6641057_8 - - - - 0.0000000000000000696 82.0
TLS3_k127_6642186_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 389.0
TLS3_k127_6642186_1 RNA polymerase sigma K03087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 369.0
TLS3_k127_6642186_2 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007696 282.0
TLS3_k127_6642186_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008839 292.0
TLS3_k127_6642186_4 COG0739 Membrane proteins related to metalloendopeptidases K06194 - - 0.000000000000000000000000000000000000000000000000000000000009092 220.0
TLS3_k127_6642186_5 CobW/HypB/UreG, nucleotide-binding domain K03189 - - 0.0000000000000000000000000000000000000000000000000001564 186.0
TLS3_k127_6669517_0 - - - - 7.97e-200 627.0
TLS3_k127_6669517_1 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 544.0
TLS3_k127_6669517_2 Redoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000006882 243.0
TLS3_k127_6669517_3 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000104 221.0
TLS3_k127_6669517_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000287 207.0
TLS3_k127_6669517_5 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.00000000000000000000000000000000000000000000000000004907 188.0
TLS3_k127_6669517_6 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00000000000000000000000000000000000002767 149.0
TLS3_k127_6669517_7 Cytochrome c - - - 0.000000000000000000000005133 104.0
TLS3_k127_6676939_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0 1081.0
TLS3_k127_6676939_1 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 451.0
TLS3_k127_6676939_2 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 393.0
TLS3_k127_6676939_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008301 248.0
TLS3_k127_6676939_4 Domain of unknown function (DUF4824) - - - 0.0000000000000000000000000000000000000001552 169.0
TLS3_k127_6676939_5 Alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.0000000000000000000000000000000003661 132.0
TLS3_k127_6676939_6 Fe2 transport system protein A K04758 GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015684,GO:0030001,GO:0033554,GO:0034220,GO:0034755,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070627,GO:0070838,GO:0072511,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098707,GO:0098711,GO:0098739,GO:0099587,GO:1903874 - 0.000000000000000000000000004672 113.0
TLS3_k127_6676939_7 FeoC like transcriptional regulator - - - 0.0000000000000000000000001053 117.0
TLS3_k127_6676939_8 Pfam FeoA K04758 - - 0.0000000000000000000000002152 110.0
TLS3_k127_6700102_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1233.0
TLS3_k127_6700102_1 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 557.0
TLS3_k127_6700102_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 395.0
TLS3_k127_6700102_3 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 368.0
TLS3_k127_6700102_4 HAD-hyrolase-like K22292 - 3.1.3.105 0.00000000000000000000000000000000000000000000000000000000000000000005914 237.0
TLS3_k127_6700102_5 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000000000000000000167 226.0
TLS3_k127_6741367_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06158 - - 2.763e-268 836.0
TLS3_k127_6741367_1 glutamate--cysteine ligase K01919 - 6.3.2.2 1.861e-204 654.0
TLS3_k127_6741367_2 Eco57I restriction-modification methylase K07317 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 463.0
TLS3_k127_6741367_3 - - - - 0.0001317 49.0
TLS3_k127_6813752_0 fad dependent oxidoreductase K07137 - - 2.6e-263 819.0
TLS3_k127_6813752_1 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006409 602.0
TLS3_k127_6813752_10 Transglycosylase SLT domain K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 327.0
TLS3_k127_6813752_11 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 289.0
TLS3_k127_6813752_12 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000004142 262.0
TLS3_k127_6813752_13 Belongs to the UPF0225 family K09858 - - 0.000000000000000000000000000000000000000000000000006524 183.0
TLS3_k127_6813752_14 - - - - 0.0000000000000000000201 97.0
TLS3_k127_6813752_15 - - - - 0.00000003408 57.0
TLS3_k127_6813752_2 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 506.0
TLS3_k127_6813752_3 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 492.0
TLS3_k127_6813752_4 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 468.0
TLS3_k127_6813752_5 (Lipo)protein K07287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005122 452.0
TLS3_k127_6813752_6 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 446.0
TLS3_k127_6813752_7 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 402.0
TLS3_k127_6813752_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 337.0
TLS3_k127_6813752_9 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 328.0
TLS3_k127_6867298_0 Belongs to the aconitase IPM isomerase family K01682 - 4.2.1.3,4.2.1.99 0.0 1176.0
TLS3_k127_6867298_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00016,K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.27,1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 533.0
TLS3_k127_6867298_2 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 466.0
TLS3_k127_6867298_3 transcriptional K03710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 382.0
TLS3_k127_6867298_4 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000524 223.0
TLS3_k127_6867298_5 Succinate dehydrogenase, hydrophobic K00242 - - 0.000000000000000000000000000000000000000000000006241 175.0
TLS3_k127_6867298_6 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.0000000000000000000000000000000000000007665 151.0
TLS3_k127_6880689_0 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008161 426.0
TLS3_k127_6880689_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000267 278.0
TLS3_k127_6880689_2 chain release factor K15034 - - 0.00000000000000000000000000000000000000000000000000167 189.0
TLS3_k127_6880689_4 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000004735 145.0
TLS3_k127_6880689_5 COG2346, Truncated hemoglobins - - - 0.0000000000000000000000000000000001959 138.0
TLS3_k127_6880689_6 - - - - 0.00000000000000000001245 97.0
TLS3_k127_6883180_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 460.0
TLS3_k127_6883180_1 Bacterial extracellular solute-binding protein K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 430.0
TLS3_k127_6883180_2 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 303.0
TLS3_k127_6883180_3 Belongs to the ABC transporter superfamily K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000004121 254.0
TLS3_k127_6899408_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K03698 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 297.0
TLS3_k127_6899408_1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000005103 252.0
TLS3_k127_6899408_2 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05591,K05592 GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008135,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0042623,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065007,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000005118 231.0
TLS3_k127_6899408_3 Pfam:DUF3596 K14059 - - 0.00000000000000000000000000000000000000000000000000000000949 209.0
TLS3_k127_6899408_4 Cro/C1-type HTH DNA-binding domain - - - 0.00000000000000000000000006556 108.0
TLS3_k127_6899408_5 Belongs to the AAA ATPase family K11338,K12196,K13254 GO:0000166,GO:0000502,GO:0000731,GO:0002020,GO:0002082,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0006139,GO:0006140,GO:0006163,GO:0006259,GO:0006281,GO:0006301,GO:0006302,GO:0006464,GO:0006486,GO:0006487,GO:0006508,GO:0006511,GO:0006515,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006914,GO:0006919,GO:0006950,GO:0006974,GO:0007034,GO:0007041,GO:0008047,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0008333,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009109,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009896,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0010562,GO:0010604,GO:0010646,GO:0010647,GO:0010918,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016032,GO:0016043,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016504,GO:0016567,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017144,GO:0018130,GO:0018193,GO:0018196,GO:0018279,GO:0019058,GO:0019079,GO:0019219,GO:0019220,GO:0019222,GO:0019362,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019899,GO:0019902,GO:0019903,GO:0019904,GO:0019941,GO:0019985,GO:0022411,GO:0022607,GO:0023051,GO:0023056,GO:0030111,GO:0030162,GO:0030163,GO:0030177,GO:0030234,GO:0030433,GO:0030554,GO:0030808,GO:0030810,GO:0030970,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031331,GO:0031334,GO:0031399,GO:0031401,GO:0031593,GO:0031625,GO:0031974,GO:0031981,GO:0031984,GO:0032268,GO:0032270,GO:0032434,GO:0032436,GO:0032446,GO:0032509,GO:0032510,GO:0032527,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0032991,GO:0033036,GO:0033554,GO:0034098,GO:0034214,GO:0034404,GO:0034613,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0034976,GO:0035639,GO:0035800,GO:0035861,GO:0035966,GO:0035967,GO:0036094,GO:0036211,GO:0036435,GO:0036503,GO:0036513,GO:0042175,GO:0042176,GO:0042221,GO:0042287,GO:0042288,GO:0042325,GO:0042327,GO:0042391,GO:0042726,GO:0042728,GO:0042802,GO:0042886,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043161,GO:0043167,GO:0043168,GO:0043170,GO:0043209,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043280,GO:0043281,GO:0043412,GO:0043413,GO:0043457,GO:0043467,GO:0043531,GO:0043632,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044389,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044427,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045184,GO:0045732,GO:0045838,GO:0045862,GO:0045935,GO:0045937,GO:0045981,GO:0046034,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046907,GO:0048193,GO:0048471,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051186,GO:0051187,GO:0051234,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051336,GO:0051345,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0051716,GO:0051788,GO:0051881,GO:0052547,GO:0052548,GO:0055086,GO:0060255,GO:0060828,GO:0061134,GO:0061136,GO:0061857,GO:0061919,GO:0062012,GO:0062013,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070085,GO:0070647,GO:0070727,GO:0070841,GO:0070842,GO:0070887,GO:0071218,GO:0071310,GO:0071702,GO:0071704,GO:0071705,GO:0071712,GO:0071840,GO:0071897,GO:0071985,GO:0072387,GO:0072389,GO:0072521,GO:0072524,GO:0080090,GO:0090085,GO:0090263,GO:0090304,GO:0090734,GO:0097159,GO:0097352,GO:0097367,GO:0098772,GO:0098796,GO:0098827,GO:0140030,GO:1900371,GO:1900373,GO:1900542,GO:1900544,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1901800,GO:1902494,GO:1903003,GO:1903004,GO:1903006,GO:1903007,GO:1903050,GO:1903052,GO:1903320,GO:1903322,GO:1903362,GO:1903364,GO:1903513,GO:1903578,GO:1903580,GO:1903715,GO:1903862,GO:1904288,GO:1904949,GO:1905368,GO:1905369,GO:1990381,GO:1990730,GO:2000058,GO:2000060,GO:2000116,GO:2000152,GO:2000158,GO:2001056,GO:2001169,GO:2001171 3.6.4.12,3.6.4.3 0.0000000000000000000000001265 117.0
TLS3_k127_6899408_6 - - - - 0.0000000000000000000001256 99.0
TLS3_k127_6899408_7 Squalene epoxidase K03185 - - 0.00001324 50.0
TLS3_k127_6905486_0 Proton-conducting membrane transporter - - - 1.38e-235 737.0
TLS3_k127_6905486_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 579.0
TLS3_k127_6905486_2 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000001508 141.0
TLS3_k127_6906376_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 2.679e-294 915.0
TLS3_k127_6906376_1 Polyphosphate kinase 2 (PPK2) - - - 3.803e-260 807.0
TLS3_k127_6906376_10 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000006319 216.0
TLS3_k127_6906376_11 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000000000003552 162.0
TLS3_k127_6906376_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 2.703e-205 646.0
TLS3_k127_6906376_3 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 578.0
TLS3_k127_6906376_4 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 466.0
TLS3_k127_6906376_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 383.0
TLS3_k127_6906376_6 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 334.0
TLS3_k127_6906376_7 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 299.0
TLS3_k127_6906376_8 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 286.0
TLS3_k127_6906376_9 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000001869 260.0
TLS3_k127_6920895_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 389.0
TLS3_k127_6920895_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000013 113.0
TLS3_k127_6920895_2 molybdenum cofactor K03831 - 2.7.7.75 0.0000000000000003132 78.0
TLS3_k127_6922608_0 ABC-type branched-chain amino acid transport system, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 592.0
TLS3_k127_6922608_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002831 443.0
TLS3_k127_6922608_2 amino acid transport system, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000009767 205.0
TLS3_k127_6953679_0 Malic enzyme K00029 - 1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 613.0
TLS3_k127_6953679_1 Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 367.0
TLS3_k127_6953679_2 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000003147 241.0
TLS3_k127_6955848_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 7.582e-197 625.0
TLS3_k127_6955848_1 COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 342.0
TLS3_k127_6955848_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001912 235.0
TLS3_k127_6964120_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 533.0
TLS3_k127_6964120_1 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000001144 134.0
TLS3_k127_6964120_2 - - - - 0.0000000000000000000000002442 117.0
TLS3_k127_6967357_0 Sodium:solute symporter family - - - 6.377e-315 977.0
TLS3_k127_6967357_1 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 552.0
TLS3_k127_6967357_10 - - - - 0.000000000000000000000000000000002537 130.0
TLS3_k127_6967357_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 426.0
TLS3_k127_6967357_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007238 333.0
TLS3_k127_6967357_4 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003595 283.0
TLS3_k127_6967357_5 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000007803 240.0
TLS3_k127_6967357_6 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000007701 221.0
TLS3_k127_6967357_7 Domain of unknown function (DUF4212) - - - 0.00000000000000000000000000000000000000007345 154.0
TLS3_k127_6967357_8 Protein of unknown function, DUF485 - - - 0.000000000000000000000000000000000000008309 147.0
TLS3_k127_6967357_9 Domain of unknown function (DUF4212) - - - 0.0000000000000000000000000000000000003371 141.0
TLS3_k127_6975595_0 Alpha-amylase domain K01187 - 3.2.1.20 3.104e-250 786.0
TLS3_k127_6987655_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 568.0
TLS3_k127_6987655_1 Aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 287.0
TLS3_k127_6987655_2 Negative regulator of beta-lactamase expression K03806 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005483 267.0
TLS3_k127_6987655_3 Histone H1-like nucleoprotein HC2 K11275 - - 0.00000000000000000000000000006222 121.0
TLS3_k127_6993938_0 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 507.0
TLS3_k127_6993938_1 Flagellar hook-associated protein 2 N-terminus K02407 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 395.0
TLS3_k127_6993938_10 FlaG protein K06603 - - 0.00000000000003972 74.0
TLS3_k127_6993938_2 His Kinase A (phosphoacceptor) domain K10942 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 374.0
TLS3_k127_6993938_3 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.00000000000000000000000000000000000000000000000000000000000000000006864 239.0
TLS3_k127_6993938_4 Flagellar hook-length control protein FliK - - - 0.0000000000000000000000000000000000000000000000000000000002339 217.0
TLS3_k127_6993938_5 PFAM Flagellar protein FliS K02422 - - 0.0000000000000000000000000000000000000000002541 164.0
TLS3_k127_6993938_6 Flagellar hook-basal body K02408 - - 0.00000000000000000000000000000000799 130.0
TLS3_k127_6993938_7 cytoplasmic domain of flagellar protein FhlB K04061 - - 0.00000000000000000000000000000002822 128.0
TLS3_k127_6993938_8 Flagellar protein FliT K02423 - - 0.0000000000000001447 85.0
TLS3_k127_6993938_9 Flagellar protein FliT K02423 - - 0.000000000000004538 82.0
TLS3_k127_6994471_0 COG1055 Na H antiporter NhaD and related arsenite permeases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 428.0
TLS3_k127_6994471_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 375.0
TLS3_k127_6994471_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006147 241.0
TLS3_k127_6994471_3 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000159 162.0
TLS3_k127_6994471_4 phosphonate metabolism protein PhnM K06162 - 3.6.1.63 0.00000000000000000000000000000000836 130.0
TLS3_k127_7015473_0 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 311.0
TLS3_k127_7015473_1 Diguanylate cyclase - - - 0.0000000000000000000001896 100.0
TLS3_k127_7015473_2 LysR substrate binding domain K03566 - - 0.00000418 49.0
TLS3_k127_7023635_0 Cytochrome c554 and c-prime - - - 1.511e-279 869.0
TLS3_k127_7023635_1 cytochrome K17230 - - 0.0000000009776 70.0
TLS3_k127_7050323_0 Acyl-CoA dehydrogenase, C-terminal domain K00253 - 1.3.8.4 5.151e-226 712.0
TLS3_k127_7050323_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 544.0
TLS3_k127_7050323_2 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 407.0
TLS3_k127_7050323_3 poly(R)-hydroxyalkanoic acid synthase K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 289.0
TLS3_k127_7050323_4 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000132 188.0
TLS3_k127_7050323_5 transcriptional - - - 0.00000000000000000000000000000000000000001439 157.0
TLS3_k127_7054471_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145,K05829 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000005046 209.0
TLS3_k127_7054471_1 Mo-molybdopterin cofactor biosynthetic process - - - 0.00000000000000009077 83.0
TLS3_k127_7067814_0 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 421.0
TLS3_k127_7067814_1 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 357.0
TLS3_k127_7067814_2 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 291.0
TLS3_k127_7067814_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000463 139.0
TLS3_k127_7080590_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 4.046e-198 628.0
TLS3_k127_7080590_1 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 480.0
TLS3_k127_7080590_2 glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 366.0
TLS3_k127_7080590_3 Domain of unknown function (DUF4124) - - - 0.000000000000000000000000000000001566 135.0
TLS3_k127_7081080_0 Histidine kinase K07673 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 381.0
TLS3_k127_7081080_1 response regulator K07684 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000293 286.0
TLS3_k127_7081080_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000003052 248.0
TLS3_k127_7085996_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 1.782e-195 621.0
TLS3_k127_7085996_1 Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000001196 204.0
TLS3_k127_7085996_2 protein conserved in bacteria K09922 - - 0.000000000000000000000000000000000000000000000000000003189 198.0
TLS3_k127_7085996_3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000002912 189.0
TLS3_k127_7096408_0 Membrane - - - 1.02e-203 674.0
TLS3_k127_7096408_1 Protein of unknown function (DUF3050) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 289.0
TLS3_k127_7096408_2 Protein of unknown function (DUF3999) - - - 0.000000000000000000000000000000000000000000000000000000000000000001065 251.0
TLS3_k127_7096408_3 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000009311 125.0
TLS3_k127_7096408_4 - - - - 0.000000000000000000001561 99.0
TLS3_k127_7096408_5 glutamate--cysteine ligase K01919 - 6.3.2.2 0.0000000000000000008266 86.0
TLS3_k127_7109302_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1214.0
TLS3_k127_7109302_1 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.291e-287 900.0
TLS3_k127_7109302_10 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000006677 167.0
TLS3_k127_7109302_11 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain - - - 0.00000000000000000000008804 111.0
TLS3_k127_7109302_2 Diguanylate cyclase - - - 1.396e-228 744.0
TLS3_k127_7109302_3 Belongs to the cysteine synthase cystathionine beta- synthase family K12339 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 497.0
TLS3_k127_7109302_4 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 435.0
TLS3_k127_7109302_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003575 339.0
TLS3_k127_7109302_6 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004475 280.0
TLS3_k127_7109302_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001793 264.0
TLS3_k127_7109302_8 UPF0114 protein - - - 0.00000000000000000000000000000000000000000000000000000000001426 234.0
TLS3_k127_7109302_9 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000002948 209.0
TLS3_k127_7112660_0 Belongs to the N(4) N(6)-methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 497.0
TLS3_k127_7112660_1 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 440.0
TLS3_k127_7112660_2 - - - - 0.00000000000000000000000000000005919 126.0
TLS3_k127_7116056_0 cation transport ATPase K01533 - 3.6.3.4 0.0 1011.0
TLS3_k127_7116056_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 347.0
TLS3_k127_7116056_2 cytochrome oxidase maturation protein cbb3-type - - - 0.0000000000000000634 82.0
TLS3_k127_7117804_0 COG1982 Arginine lysine ornithine decarboxylases K01584 - 4.1.1.19 0.0 1398.0
TLS3_k127_7117804_1 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000001735 232.0
TLS3_k127_7117804_2 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287,K18590 GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0019842,GO:0031406,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051870,GO:0051871,GO:0055114,GO:0070401,GO:0070402,GO:0072341,GO:0097159,GO:1901265,GO:1901363 1.5.1.3 0.0000000000000000000000000000000000000000000000000001792 195.0
TLS3_k127_7117804_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000004974 153.0
TLS3_k127_7120094_0 COG2202 FOG PAS PAC domain K03776 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 427.0
TLS3_k127_7120094_1 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 387.0
TLS3_k127_7120094_2 Type IV pili methyl-accepting chemotaxis transducer N-term - - - 0.00000000000000009246 89.0
TLS3_k127_7125029_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 3.574e-255 802.0
TLS3_k127_7125029_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 2.703e-195 616.0
TLS3_k127_7125029_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 572.0
TLS3_k127_7125029_3 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 404.0
TLS3_k127_7125029_4 membrane transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000001127 221.0
TLS3_k127_7125029_5 tryptophan synthase subunit beta - - - 0.0000000000000000000004411 102.0
TLS3_k127_7125029_6 ROK family K00845,K00847,K00884 - 2.7.1.2,2.7.1.4,2.7.1.59 0.000000000000000000001517 94.0
TLS3_k127_7141038_0 Chain length determinant protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 554.0
TLS3_k127_7141038_1 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 366.0
TLS3_k127_7141038_2 TIGRFAM peptidyl-prolyl cis-trans isomerase, EpsD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 329.0
TLS3_k127_7141038_3 Putative beta-barrel porin 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 311.0
TLS3_k127_7141038_4 AAA domain K08252,K16692 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000008283 241.0
TLS3_k127_7170497_0 PFAM Conserved TM helix repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008093 252.0
TLS3_k127_7170497_1 Alpha-amylase domain K01187 - 3.2.1.20 0.0000000000000000000000000000000000000000000000000000000355 203.0
TLS3_k127_7170497_2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.0000000000000000000000007918 104.0
TLS3_k127_7188004_0 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 461.0
TLS3_k127_7188004_1 Secretin N-terminal domain K02453,K12282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 417.0
TLS3_k127_7188004_2 AAA domain K02450,K12283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008532 355.0
TLS3_k127_7188004_3 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000002816 265.0
TLS3_k127_7188004_4 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001492 251.0
TLS3_k127_7188004_5 Tetratricopeptide repeat K12284 - - 0.000000000000000000000000002594 130.0
TLS3_k127_7189807_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 2.073e-242 758.0
TLS3_k127_7189807_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 589.0
TLS3_k127_7189807_2 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 570.0
TLS3_k127_7189807_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 569.0
TLS3_k127_7189807_4 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000000000002674 128.0
TLS3_k127_7189807_5 - - - - 0.000000000000000000000000371 120.0
TLS3_k127_7195833_0 Belongs to the malate synthase family K01638 - 2.3.3.9 4.042e-257 798.0
TLS3_k127_7195833_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 7.342e-196 617.0
TLS3_k127_7195833_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 405.0
TLS3_k127_7195833_3 Tripartite ATP-independent periplasmic - - - 0.000000000000000000009509 93.0
TLS3_k127_7203380_0 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 1.998e-201 632.0
TLS3_k127_7203380_1 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00124,K18005 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007926 512.0
TLS3_k127_7214409_0 Uncharacterized protein conserved in bacteria (DUF2331) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 373.0
TLS3_k127_7214409_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 327.0
TLS3_k127_7214409_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 293.0
TLS3_k127_7214409_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.0000006716 54.0
TLS3_k127_7218308_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009305 404.0
TLS3_k127_7218308_1 Glycosyltransferase Family 4 K00786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 374.0
TLS3_k127_7218308_2 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.0000000000000000000000000000000000000000000000000009052 186.0
TLS3_k127_7258795_0 Domain related to MnhB subunit of Na+/H+ antiporter K05559 - - 0.0 1146.0
TLS3_k127_7258795_1 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006288 486.0
TLS3_k127_7258795_2 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 329.0
TLS3_k127_7258795_3 Mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004573 320.0
TLS3_k127_7258795_4 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004801 259.0
TLS3_k127_7258795_5 Na Pi-cotransporter K03324 - - 0.0000000000000000000000000000000000000004117 155.0
TLS3_k127_7258795_6 Pfam:DUF1049 - - - 0.000000000000000002981 92.0
TLS3_k127_7281495_0 Participates in both transcription termination and antitermination K02600 - - 5.34e-244 761.0
TLS3_k127_7281495_1 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 352.0
TLS3_k127_7281495_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008212 348.0
TLS3_k127_7281495_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001525 274.0
TLS3_k127_7281495_4 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000000000000000000000007078 198.0
TLS3_k127_7288165_0 Integrase core domain - - - 1e-235 749.0
TLS3_k127_7288165_1 Integrase core domain K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 336.0
TLS3_k127_7288165_2 Helix-turn-helix domain K07483 - - 0.0000000000000000000000000000000000000002743 151.0
TLS3_k127_7288165_3 Integrase core domain - - - 0.000002216 54.0
TLS3_k127_7288219_0 Glycolate oxidase subunit GlcD K00104 - 1.1.3.15 2.115e-237 742.0
TLS3_k127_7288219_1 Putative diguanylate phosphodiesterase - - - 1.131e-210 668.0
TLS3_k127_7288219_2 Putative metallopeptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 462.0
TLS3_k127_7288219_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 346.0
TLS3_k127_7288219_4 FAD binding K11472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 301.0
TLS3_k127_7288219_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003987 274.0
TLS3_k127_7288219_6 Peptidase S24-like - - - 0.0000000000000000000000000000003174 131.0
TLS3_k127_7288219_7 - - - - 0.000000000000000000000000000003502 124.0
TLS3_k127_7288219_8 - - - - 0.0000000000000001803 81.0
TLS3_k127_7288219_9 - - - - 0.000000000003065 78.0
TLS3_k127_7288421_0 Belongs to the peptidase S1C family K04691,K04772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 514.0
TLS3_k127_7288421_1 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 502.0
TLS3_k127_7288421_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 369.0
TLS3_k127_7288421_3 NIF3 (NGG1p interacting factor 3) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 340.0
TLS3_k127_7288421_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008454 283.0
TLS3_k127_7288421_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000003165 238.0
TLS3_k127_7288421_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000000000000000000000000002242 132.0
TLS3_k127_7288421_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000703 42.0
TLS3_k127_7298923_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 7.485e-241 756.0
TLS3_k127_7298923_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000002319 87.0
TLS3_k127_7298923_2 Nitrogen regulatory protein P-II K04751 - - 0.00000000007717 63.0
TLS3_k127_7304467_0 COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 456.0
TLS3_k127_7304467_1 signal transduction protein containing EAL and modified HD-GYP domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 421.0
TLS3_k127_7304467_2 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 322.0
TLS3_k127_7304467_3 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001945 244.0
TLS3_k127_7304467_4 membrane K08973 - - 0.0000000000000000000000000000000000000000000006164 181.0
TLS3_k127_7325966_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009888 459.0
TLS3_k127_7325966_1 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA K06917 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 432.0
TLS3_k127_7325966_2 squalene-associated FAD-dependent desaturase K21677 - 1.17.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 428.0
TLS3_k127_7325966_3 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 396.0
TLS3_k127_7325966_4 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 334.0
TLS3_k127_7325966_5 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001458 261.0
TLS3_k127_7325966_6 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000001751 224.0
TLS3_k127_7325966_7 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000001573 138.0
TLS3_k127_7331913_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 1.406e-298 925.0
TLS3_k127_7331913_1 Type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 535.0
TLS3_k127_7331913_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000002492 209.0
TLS3_k127_7331913_11 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000005379 153.0
TLS3_k127_7331913_12 NTP binding protein (Contains STAS domain) K04749,K07122 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716 - 0.000000000000004839 80.0
TLS3_k127_7331913_2 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 409.0
TLS3_k127_7331913_3 abc transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 406.0
TLS3_k127_7331913_4 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 404.0
TLS3_k127_7331913_5 VacJ family lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 323.0
TLS3_k127_7331913_6 type II secretion system protein K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 339.0
TLS3_k127_7331913_7 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 299.0
TLS3_k127_7331913_8 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001134 258.0
TLS3_k127_7331913_9 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000007183 222.0
TLS3_k127_7346437_0 Belongs to the KdsA family K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 474.0
TLS3_k127_7346437_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 308.0
TLS3_k127_7346437_2 Domain of unknown function (DUF1330) - - - 0.00000000000000000002867 103.0
TLS3_k127_7372533_0 Phosphoglucomutase K15778 - 5.4.2.2,5.4.2.8 1.613e-236 737.0
TLS3_k127_7372533_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 2.838e-195 614.0
TLS3_k127_7372533_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 486.0
TLS3_k127_7372533_3 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 368.0
TLS3_k127_7372533_4 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000001906 168.0
TLS3_k127_7372533_5 Zinc-finger domain - - - 0.00000000000000000000000003726 112.0
TLS3_k127_7383030_0 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 408.0
TLS3_k127_7383030_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 373.0
TLS3_k127_7383030_2 import inner membrane translocase subunit Tim44 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001264 277.0
TLS3_k127_7383030_3 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000002515 227.0
TLS3_k127_7383030_4 Protein of unknown function (DUF971) - - - 0.000000000000000000000000000000000000000000000000000000034 200.0
TLS3_k127_7383030_5 protein conserved in bacteria K03690 - - 0.000000005812 63.0
TLS3_k127_7390414_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 3.959e-291 904.0
TLS3_k127_7390414_1 Rod shape-determining protein MreB K03569 - - 1.889e-207 648.0
TLS3_k127_7390414_10 Belongs to the UPF0250 family K09158 - - 0.000000000000000000000000000000000001767 139.0
TLS3_k127_7390414_11 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000001226 131.0
TLS3_k127_7390414_2 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 487.0
TLS3_k127_7390414_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 447.0
TLS3_k127_7390414_4 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 398.0
TLS3_k127_7390414_5 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 323.0
TLS3_k127_7390414_6 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008755 278.0
TLS3_k127_7390414_7 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001092 277.0
TLS3_k127_7390414_8 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001318 296.0
TLS3_k127_7390414_9 shape-determining protein K03571 - - 0.0000000000000000000000000000000000000000000000000000000000009303 216.0
TLS3_k127_7445223_0 - - - - 0.000000000000000000000000000000009808 134.0
TLS3_k127_7445223_1 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000006914 108.0
TLS3_k127_7445223_3 luxR family - - - 0.00000000000000000004821 102.0
TLS3_k127_7445223_4 - - - - 0.00000004833 63.0
TLS3_k127_7445403_0 5'-nucleotidase, C-terminal domain K11751,K17224 - 3.1.3.5,3.6.1.45 1.532e-290 906.0
TLS3_k127_7445403_1 PUA-like domain K00958 - 2.7.7.4 1.592e-235 733.0
TLS3_k127_7445403_10 Adenosine-5'-phosphosulfate reductase beta subunit K00395 - 1.8.99.2 0.000000000000000000000000001064 111.0
TLS3_k127_7445403_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000001029 108.0
TLS3_k127_7445403_2 Peptidase M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 499.0
TLS3_k127_7445403_3 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002422 259.0
TLS3_k127_7445403_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000001776 239.0
TLS3_k127_7445403_5 Cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000000000000000000007209 220.0
TLS3_k127_7445403_6 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000001952 192.0
TLS3_k127_7445403_7 sulfur oxidation protein SoxY K17226 - - 0.0000000000000000000000000000000000000000000000000901 183.0
TLS3_k127_7445403_8 AntiSigma factor - - - 0.00000000000000000000000000000000009786 145.0
TLS3_k127_7445403_9 Sulphur oxidation protein SoxZ K17227 - - 0.0000000000000000000000000000000004388 135.0
TLS3_k127_7456550_0 COG0643 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 0.0 1202.0
TLS3_k127_7456550_1 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 532.0
TLS3_k127_7456550_2 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002813 271.0
TLS3_k127_7456550_3 Pyrimidine operon attenuation protein uracil phosphoribosyltransferase K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000001508 186.0
TLS3_k127_7456550_4 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000000000000000009703 172.0
TLS3_k127_7456550_5 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000008989 154.0
TLS3_k127_7462215_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008891 365.0
TLS3_k127_7462215_1 abc transporter atp-binding protein K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 313.0
TLS3_k127_7462215_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 286.0
TLS3_k127_7462215_3 Modulates RecA activity K03565 - - 0.00000000000000000000000000000000000001506 149.0
TLS3_k127_7485914_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 403.0
TLS3_k127_7485914_1 Pfam Dinitrogenase iron-molybdenum cofactor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 296.0
TLS3_k127_7485914_2 NifT/FixU protein K02593 - - 0.0000000000000000000000000000009804 122.0
TLS3_k127_7485914_3 4Fe-4S binding domain - - - 0.000000000000000000000000000001796 121.0
TLS3_k127_7485914_4 - - - - 0.0000000001785 68.0
TLS3_k127_7522250_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1027.0
TLS3_k127_7522250_1 Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 575.0
TLS3_k127_7522250_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 481.0
TLS3_k127_7522250_3 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 481.0
TLS3_k127_7522250_4 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000003462 263.0
TLS3_k127_7537236_0 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 451.0
TLS3_k127_7537236_1 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 300.0
TLS3_k127_7537236_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000003027 212.0
TLS3_k127_766791_0 Transposase domain (DUF772) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 528.0
TLS3_k127_769328_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 357.0
TLS3_k127_769328_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002689 276.0
TLS3_k127_7744584_0 PAC sensor-containing diguanylate cyclase phosphodiesterase - - - 0.0 1033.0
TLS3_k127_7744584_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 363.0
TLS3_k127_7744584_2 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.00000000000000000000000000000000000000000000000000000007897 196.0
TLS3_k127_7744584_3 COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000002044 194.0
TLS3_k127_7769218_0 Circularly permuted ATP-grasp type 2 - - - 4.799e-215 671.0
TLS3_k127_7769218_1 TOBE domain K02019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 389.0
TLS3_k127_7769218_2 A predicted alpha-helical domain with a conserved ER motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 402.0
TLS3_k127_7769218_3 PFAM 20S proteasome, A and B subunits K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 353.0
TLS3_k127_7769218_4 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 336.0
TLS3_k127_7769218_5 Belongs to the NadC ModD family K03813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 334.0
TLS3_k127_7769218_6 transglutaminase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001571 270.0
TLS3_k127_7769218_7 NifQ K15790 - - 0.0000000000000000000000000000000000000000000000000000000000000000002229 236.0
TLS3_k127_7769218_8 Binding-protein-dependent transport system inner membrane component K02018 - - 0.0000000000000000000000000000000000000000000000000000536 187.0
TLS3_k127_7775934_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 3.732e-272 843.0
TLS3_k127_7775934_1 Nitrite and sulphite reductase 4Fe-4S domain K11180 - 1.8.99.5 8.216e-237 738.0
TLS3_k127_7775934_2 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 354.0
TLS3_k127_7775934_3 Sulfurtransferase TusA - - - 0.0000000000000000000000000000000000000000000001248 173.0
TLS3_k127_7775934_4 - - - - 0.00000000000000000000000000000000000000002005 159.0
TLS3_k127_7775934_5 DsrC like protein K11179 - - 0.000000000000000000000000000003668 130.0
TLS3_k127_7775934_6 Cas6 Crispr - - - 0.000000000000000000000000002204 121.0
TLS3_k127_7775934_7 - - - - 0.000000000000000002354 89.0
TLS3_k127_7775934_8 Nitrite and sulphite reductase 4Fe-4S domain K11181 - 1.8.99.5 0.0001278 45.0
TLS3_k127_7786905_0 Putative diguanylate phosphodiesterase - - - 0.0 2533.0
TLS3_k127_7786905_1 Putative diguanylate phosphodiesterase K03320 - - 9.011e-201 645.0
TLS3_k127_7786905_2 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000672 302.0
TLS3_k127_7786905_3 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005037 289.0
TLS3_k127_7786905_4 membrane - - - 0.00000000000000000000000000000000000000000009265 163.0
TLS3_k127_7786905_5 Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000001591 160.0
TLS3_k127_7786905_6 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000000000000002701 135.0
TLS3_k127_7786905_7 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000002297 83.0
TLS3_k127_7789178_0 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 377.0
TLS3_k127_7789178_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004346 242.0
TLS3_k127_7795172_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1102.0
TLS3_k127_7795172_1 With GlrK is part of a two-component signal transduction system regulating glmY K07715 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 400.0
TLS3_k127_7795172_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001675 297.0
TLS3_k127_7795172_3 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009566 243.0
TLS3_k127_7795172_4 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000000000000003241 160.0
TLS3_k127_7795172_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000001551 131.0
TLS3_k127_7795172_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000001593 128.0
TLS3_k127_7795172_7 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000008473 64.0
TLS3_k127_7795172_8 - - - - 0.00001427 48.0
TLS3_k127_7795172_9 (ABC) transporter - - - 0.0001814 51.0
TLS3_k127_7818002_0 PFAM Serine threonine protein kinase-related - - - 0.00000000000000000000000000000000000000000000000000000000000000001515 244.0
TLS3_k127_7818002_1 SURF1 family - - - 0.000000000000000000000000000000002476 139.0
TLS3_k127_7823388_0 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 1.526e-243 766.0
TLS3_k127_7823388_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 5.27e-228 712.0
TLS3_k127_7823388_10 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000000000001013 162.0
TLS3_k127_7823388_11 Protein of unknown function (DUF2721) - - - 0.00000000000000000000000000000000000003746 150.0
TLS3_k127_7823388_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 574.0
TLS3_k127_7823388_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 457.0
TLS3_k127_7823388_4 Transcriptional regulator, LysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 409.0
TLS3_k127_7823388_5 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 342.0
TLS3_k127_7823388_6 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008519 252.0
TLS3_k127_7823388_7 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002188 241.0
TLS3_k127_7823388_8 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000172 242.0
TLS3_k127_7823388_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000001019 220.0
TLS3_k127_7824260_0 Domain of unknown function (DUF4131) K02238 - - 1.3e-255 811.0
TLS3_k127_7824260_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 2.293e-247 767.0
TLS3_k127_7824260_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 1.141e-200 637.0
TLS3_k127_7824260_3 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 575.0
TLS3_k127_7824260_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 394.0
TLS3_k127_7824260_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 314.0
TLS3_k127_7824260_6 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 315.0
TLS3_k127_7824260_7 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000000000000000007496 179.0
TLS3_k127_7824260_8 protein conserved in bacteria K09928 - - 0.000000000000000000000000000004251 122.0
TLS3_k127_7824260_9 LTXXQ motif family protein - - - 0.00000000000002552 81.0
TLS3_k127_7826593_0 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate K01815 - 5.3.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 458.0
TLS3_k127_7826593_1 Putative peptidoglycan binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 399.0
TLS3_k127_7826593_2 lacI family K02529 - - 0.000000000000000000000000000000006323 130.0
TLS3_k127_7826593_3 Lysozyme inhibitor LprI - - - 0.00000000000000000001796 100.0
TLS3_k127_7826593_4 ankyrin repeats - - - 0.00000000000002755 76.0
TLS3_k127_7826593_5 Lipase (class 3) - - - 0.00002328 58.0
TLS3_k127_7839442_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1498.0
TLS3_k127_7839442_1 Outer membrane efflux protein K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007531 424.0
TLS3_k127_7839442_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 312.0
TLS3_k127_7839442_3 Protein of unknown function (DUF3365) - - - 0.000000000000000000000000000000000000000000000000000000001676 209.0
TLS3_k127_7839442_4 protein conserved in bacteria K03690 - - 0.0000000000000000000000000268 113.0
TLS3_k127_7860865_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 2.051e-244 758.0
TLS3_k127_7860865_1 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 307.0
TLS3_k127_7860865_2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000001587 258.0
TLS3_k127_7860865_3 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001081 248.0
TLS3_k127_7860865_4 gag-polyprotein putative aspartyl protease K06985 - - 0.0000000000000000000000000000000000000000000000000000000000002874 218.0
TLS3_k127_7860865_5 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000000000000000000000000007637 208.0
TLS3_k127_7860865_6 Protein of unknown function (DUF1255) K09913 - 2.4.2.1,2.4.2.2 0.0000000000000000000000000000000000000000000000000005002 185.0
TLS3_k127_7860865_7 Protein of unknown function (DUF2788) - - - 0.000000000000000000000000009338 111.0
TLS3_k127_7878984_0 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.0 1180.0
TLS3_k127_7878984_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1055.0
TLS3_k127_7878984_10 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 340.0
TLS3_k127_7878984_11 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005077 315.0
TLS3_k127_7878984_12 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005095 299.0
TLS3_k127_7878984_13 PFAM sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000007981 230.0
TLS3_k127_7878984_14 Protein of unknown function (DUF3124) - - - 0.000000000000000000000000000001137 128.0
TLS3_k127_7878984_15 Belongs to the universal stress protein A family - - - 0.000000000000000000000002671 107.0
TLS3_k127_7878984_2 PFAM Glycoside hydrolase 15-related - - - 4.893e-318 980.0
TLS3_k127_7878984_3 Sodium/hydrogen exchanger family K03455 - - 8.076e-201 640.0
TLS3_k127_7878984_4 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 8.425e-197 623.0
TLS3_k127_7878984_5 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 560.0
TLS3_k127_7878984_6 Protein of unknown function (DUF475) K09799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 419.0
TLS3_k127_7878984_7 Sodium hydrogen exchanger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007891 401.0
TLS3_k127_7878984_8 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 397.0
TLS3_k127_7878984_9 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 346.0
TLS3_k127_7881235_0 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 353.0
TLS3_k127_7903378_0 twitching motility protein K02669 - - 1.585e-197 619.0
TLS3_k127_7903378_1 twitching motility protein K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 400.0
TLS3_k127_7903378_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007011 308.0
TLS3_k127_7903378_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000001075 242.0
TLS3_k127_7903378_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000001447 99.0
TLS3_k127_7903378_5 integral membrane protein K02221 - - 0.000000000000000008469 96.0
TLS3_k127_7926_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 1.837e-248 783.0
TLS3_k127_7926_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000001498 170.0
TLS3_k127_7926_2 LytTr DNA-binding domain K02477,K07705 - - 0.00000000000000000000000000000000003829 144.0
TLS3_k127_7932878_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.152e-315 979.0
TLS3_k127_7932878_1 Chemoreceptor zinc-binding domain - - - 0.0000000000000000000000000000000005291 141.0
TLS3_k127_7932878_2 alpha beta - - - 0.0000000000000000000000000000002325 132.0
TLS3_k127_7932878_3 Chemoreceptor zinc-binding domain - - - 0.00000000004377 73.0
TLS3_k127_7934903_0 crp fnr family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 383.0
TLS3_k127_7934903_1 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000002289 192.0
TLS3_k127_7934903_2 Histidine kinase K07706,K15011 - 2.7.13.3 0.000000000000000000000000000000000000000003535 163.0
TLS3_k127_7942587_0 Major Facilitator - - - 6.62e-209 655.0
TLS3_k127_7942587_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 286.0
TLS3_k127_7942587_2 Pfam:TPM - - - 0.000000000000000000000000000000000000007931 147.0
TLS3_k127_7960942_0 Pyridine nucleotide-disulphide oxidoreductase - - - 2.181e-293 917.0
TLS3_k127_7960942_1 PFAM Thiamine pyrophosphate K00170,K18356 - 1.2.1.58,1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 340.0
TLS3_k127_7960942_2 - - - - 0.0000000000008401 73.0
TLS3_k127_7970391_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002536 286.0
TLS3_k127_7970391_1 Outer membrane lipoprotein-sorting protein - - - 0.0000000000000000000000000000000000000000000000000000000002944 212.0
TLS3_k127_7970391_2 - - - - 0.00000000000000000000000000000001163 140.0
TLS3_k127_7993788_0 Cytochrome c bacterial - - - 2.951e-213 676.0
TLS3_k127_7993788_1 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 327.0
TLS3_k127_7993788_2 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000000000001663 211.0
TLS3_k127_7993788_3 - - - - 0.0000000000000000000000000000000000001377 144.0
TLS3_k127_7993788_4 PFAM Dinitrogenase iron-molybdenum cofactor - - - 0.0000000000000000000000000000000003063 135.0
TLS3_k127_7995371_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1551.0
TLS3_k127_7995371_1 Putative diguanylate phosphodiesterase - - - 4.235e-213 684.0
TLS3_k127_7995371_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004421 593.0
TLS3_k127_7995371_3 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 431.0
TLS3_k127_7995371_4 Domain of unknown function (DUF4202) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 313.0
TLS3_k127_7995371_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 316.0
TLS3_k127_7995371_6 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000000009166 115.0
TLS3_k127_7995371_7 - - - - 0.000000000000000000000002377 104.0
TLS3_k127_7995371_8 PFAM cobalamin (vitamin B12) biosynthesis CbiX protein K03795 - 4.99.1.3 0.00000000000000000000003019 115.0
TLS3_k127_7995371_9 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000003737 94.0
TLS3_k127_8003944_0 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 1.939e-246 767.0
TLS3_k127_8003944_1 homoserine dehydrogenase K00003 - 1.1.1.3 1.249e-238 742.0
TLS3_k127_8003944_2 Threonine synthase K01733 - 4.2.3.1 1.791e-233 729.0
TLS3_k127_8003944_3 Aminotransferase K14260 - 2.6.1.2,2.6.1.66 5.052e-229 713.0
TLS3_k127_8003944_4 PFAM Alcohol dehydrogenase zinc-binding domain protein K12957 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 495.0
TLS3_k127_8003944_5 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000658 330.0
TLS3_k127_8003944_6 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 332.0
TLS3_k127_8003944_7 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000006984 216.0
TLS3_k127_8003944_8 - - - - 0.0000000000000001078 80.0
TLS3_k127_8003944_9 Tellurite resistance protein TerB - - - 0.0008195 42.0
TLS3_k127_8004911_0 Prokaryotic N-terminal methylation motif K12285 - - 0.0000000000000000000000000000000000000000000000000000000000000002814 229.0
TLS3_k127_8004911_1 type IV pilus modification protein PilV K10927 - - 0.0000000000000000000000000000001259 129.0
TLS3_k127_8004911_2 Tfp pilus assembly protein FimT K10926 - - 0.00000000000000000000000003634 115.0
TLS3_k127_8004911_3 Pilus assembly protein K12279 - - 0.00000000000000001838 85.0
TLS3_k127_8004911_4 Pilus assembly protein PilX - - - 0.00000000000000003073 88.0
TLS3_k127_8058924_0 Glutamate synthase - - - 4.19e-291 904.0
TLS3_k127_8058924_1 Esterase of the alpha-beta hydrolase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 427.0
TLS3_k127_8058924_2 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000002554 218.0
TLS3_k127_8081809_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1234.0
TLS3_k127_8081809_1 twitching motility protein K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 579.0
TLS3_k127_8081809_10 - - - - 0.000000001191 58.0
TLS3_k127_8081809_2 PFAM Aminotransferase class I and II K14267 - 2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 573.0
TLS3_k127_8081809_3 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 542.0
TLS3_k127_8081809_4 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 444.0
TLS3_k127_8081809_5 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 394.0
TLS3_k127_8081809_6 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 302.0
TLS3_k127_8081809_7 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000019 252.0
TLS3_k127_8081809_8 DsrE/DsrF-like family K09004 - - 0.000000000000000000000000001299 117.0
TLS3_k127_8081809_9 - - - - 0.00000000000000974 83.0
TLS3_k127_8086944_0 AAA domain K07133 - - 1.405e-270 837.0
TLS3_k127_8086944_1 Part of a membrane complex involved in electron transport K03617 - - 0.0000000000000000000000000000000000000000000001141 169.0
TLS3_k127_8086944_2 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000756 108.0
TLS3_k127_8086944_3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000000000006889 93.0
TLS3_k127_8086944_4 - - - - 0.0000003925 58.0
TLS3_k127_8089762_0 COGs COG1653 ABC-type sugar transport system periplasmic component K02027 - - 6.721e-227 713.0
TLS3_k127_8089762_1 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 460.0
TLS3_k127_8089762_2 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 450.0
TLS3_k127_8089762_3 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008134 336.0
TLS3_k127_8089762_4 Glutathione S-transferase, N-terminal domain - - - 0.000000000002561 70.0
TLS3_k127_8154558_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 5.47e-203 643.0
TLS3_k127_8154558_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000001402 181.0
TLS3_k127_8154558_2 diguanylate cyclase activity - - - 0.000000000000000000000000000005064 128.0
TLS3_k127_8163427_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018,K00058 - 1.1.1.29,1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 414.0
TLS3_k127_8163427_1 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 389.0
TLS3_k127_8163427_2 mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 329.0
TLS3_k127_8163427_3 LUD domain K00782 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001501 262.0
TLS3_k127_8163427_4 Domain of unknown function (DUF3390) K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000114 222.0
TLS3_k127_8163427_5 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000002854 158.0
TLS3_k127_8172270_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 466.0
TLS3_k127_8172270_1 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 432.0
TLS3_k127_8172270_2 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 329.0
TLS3_k127_8172270_3 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000502 257.0
TLS3_k127_8172270_4 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007243 250.0
TLS3_k127_8172270_5 ApaG domain - - - 0.000000000000000000000000000000000000000000000000000004425 193.0
TLS3_k127_8174074_0 TrkA-C domain K03455 - - 1.006e-214 685.0
TLS3_k127_8174074_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 429.0
TLS3_k127_8174074_2 Phasin protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000005143 238.0
TLS3_k127_8174074_3 Prokaryotic N-terminal methylation motif - - - 0.0000000000000000000000000000000000000000000000000000000000000001854 226.0
TLS3_k127_8174074_4 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000000000004108 198.0
TLS3_k127_8174074_5 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.00000000000000000000000000000000000000000000000001606 187.0
TLS3_k127_8174074_6 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.000000000000000000000003229 111.0
TLS3_k127_8196191_0 FtsX-like permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 431.0
TLS3_k127_8196191_1 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000004802 217.0
TLS3_k127_8196191_2 MotA/TolQ/ExbB proton channel family K03561 - - 0.000000000000000000000000000000000000000001969 160.0
TLS3_k127_8196191_3 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000000000006809 151.0
TLS3_k127_8196191_4 - - - - 0.0000000000000001977 93.0
TLS3_k127_8200695_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001468 290.0
TLS3_k127_8200695_1 Protein of unknown function, DUF481 - - - 0.0000000000000000000000000000000000000000006992 163.0
TLS3_k127_8227575_0 AMP-binding enzyme K00666 - - 1.378e-272 847.0
TLS3_k127_8227575_1 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.00000000000000000000000000000007383 126.0
TLS3_k127_823480_0 pyruvate phosphate dikinase K01006,K01007 - 2.7.9.1,2.7.9.2 0.0 1557.0
TLS3_k127_823480_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 8.913e-311 974.0
TLS3_k127_823480_10 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002182 278.0
TLS3_k127_823480_11 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008861 266.0
TLS3_k127_823480_12 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000000000000000000000000000000003839 246.0
TLS3_k127_823480_13 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000002864 213.0
TLS3_k127_823480_14 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000000000000000003608 209.0
TLS3_k127_823480_15 pilus assembly protein PilZ K02676 - - 0.0000000000000000000000000000000000000000000000009806 177.0
TLS3_k127_823480_16 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000101 177.0
TLS3_k127_823480_17 ankyrin repeat K06867 - - 0.000000000000000000000000000000000006176 146.0
TLS3_k127_823480_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 8.492e-307 944.0
TLS3_k127_823480_3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 5.89e-254 789.0
TLS3_k127_823480_4 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 525.0
TLS3_k127_823480_5 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 428.0
TLS3_k127_823480_6 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 346.0
TLS3_k127_823480_7 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 329.0
TLS3_k127_823480_8 DNA polymerase III K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003826 284.0
TLS3_k127_823480_9 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001316 275.0
TLS3_k127_8275160_0 pyridine nucleotide-disulphide oxidoreductase K17218 GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114 1.8.5.4 1.484e-228 715.0
TLS3_k127_8275160_1 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 329.0
TLS3_k127_8275160_2 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 289.0
TLS3_k127_8275160_3 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000662 281.0
TLS3_k127_8275160_4 Haloacid dehalogenase-like hydrolase K20881 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000003346 248.0
TLS3_k127_8275160_5 DsrE/DsrF-like family K09004 - - 0.0000000000000000000000000000000013 140.0
TLS3_k127_8275160_6 - - - - 0.000000000000001731 79.0
TLS3_k127_8280128_0 domain, Protein - - - 1.143e-235 743.0
TLS3_k127_8290399_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 5.399e-246 764.0
TLS3_k127_8290399_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000000000000000000000000000000001076 235.0
TLS3_k127_8290399_2 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000000002936 126.0
TLS3_k127_8305842_0 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 406.0
TLS3_k127_8305842_1 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000004677 234.0
TLS3_k127_8305842_2 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 0.00008506 49.0
TLS3_k127_8348886_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004361 467.0
TLS3_k127_8348886_1 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 341.0
TLS3_k127_8350707_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 3.765e-255 791.0
TLS3_k127_8350707_1 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 381.0
TLS3_k127_8350707_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000000000000000000005459 228.0
TLS3_k127_8350707_3 PFAM Sporulation domain protein - - - 0.000000000000000000003023 101.0
TLS3_k127_8350707_4 - - - - 0.0002405 44.0
TLS3_k127_8363489_0 Glycosyl hydrolase family 57 - - - 3.384e-225 714.0
TLS3_k127_8363489_1 Belongs to the glycosyl hydrolase 57 family K22451 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000001733 205.0
TLS3_k127_8363489_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000005596 135.0
TLS3_k127_8379835_0 Molybdenum cofactor synthesis K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005147 365.0
TLS3_k127_8379835_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 340.0
TLS3_k127_8379835_2 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000000000000000000000000000000000000000001743 220.0
TLS3_k127_8404284_0 DNA topoisomerase III K03169 - 5.99.1.2 0.0 1171.0
TLS3_k127_8404284_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 508.0
TLS3_k127_8404284_2 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 430.0
TLS3_k127_8404284_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 351.0
TLS3_k127_8404284_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001528 280.0
TLS3_k127_8404284_5 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000286 263.0
TLS3_k127_8404284_6 Belongs to the Smg family K03747 - - 0.000000000000000000000000000000000000003428 153.0
TLS3_k127_8404284_7 Protein kinase domain - - - 0.000000000000000000000000000002702 123.0
TLS3_k127_8483959_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 459.0
TLS3_k127_8483959_1 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 404.0
TLS3_k127_8483959_2 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 373.0
TLS3_k127_8483959_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 312.0
TLS3_k127_8483959_4 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 305.0
TLS3_k127_8483959_5 Part of a membrane complex involved in electron transport K03612 - - 0.0000000000000000000000000000000000000000000000000000000000000006844 239.0
TLS3_k127_8483959_6 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000001047 105.0
TLS3_k127_849586_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1107.0
TLS3_k127_849586_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1102.0
TLS3_k127_849586_10 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000000001735 161.0
TLS3_k127_849586_11 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000006364 130.0
TLS3_k127_849586_12 (ABC) transporter - - - 0.00000001822 64.0
TLS3_k127_849586_13 - - - - 0.00000768 53.0
TLS3_k127_849586_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.299e-298 921.0
TLS3_k127_849586_3 Aminotransferase K00832 - 2.6.1.57 1.204e-204 646.0
TLS3_k127_849586_4 two component, sigma54 specific, transcriptional regulator, Fis family K07714,K07715 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 405.0
TLS3_k127_849586_5 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004273 329.0
TLS3_k127_849586_6 His Kinase A (phospho-acceptor) domain K07711 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003112 295.0
TLS3_k127_849586_7 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001944 243.0
TLS3_k127_849586_8 AsmA-like C-terminal region - - - 0.000000000000000000000000000000000000000000000000146 198.0
TLS3_k127_849586_9 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000000000009154 162.0
TLS3_k127_8570423_0 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009143 379.0
TLS3_k127_8570423_1 Domain of unknown function (DUF3391) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 350.0
TLS3_k127_8570423_2 Diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002257 296.0
TLS3_k127_8570423_3 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.000000000000000000000000000004779 120.0
TLS3_k127_865289_0 ferric reductase - - - 5.223e-199 627.0
TLS3_k127_865289_1 Protein of unknown function (DUF808) K09781 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 434.0
TLS3_k127_865289_2 Dihaem cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000051 265.0
TLS3_k127_865289_3 Domain of unknown function (DUF1924) - - - 0.0000000000000000000000000000000000000000004911 161.0
TLS3_k127_882877_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 3.081e-241 755.0
TLS3_k127_892341_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 7.511e-285 884.0
TLS3_k127_892341_1 Beta-lactamase - - - 3.754e-206 651.0
TLS3_k127_892341_2 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000001058 177.0
TLS3_k127_892341_3 AAA ATPase domain - - - 0.000001518 58.0
TLS3_k127_905344_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 6.914e-266 825.0
TLS3_k127_905344_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 606.0
TLS3_k127_905344_2 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 538.0
TLS3_k127_905344_3 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000615 466.0
TLS3_k127_905344_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001208 238.0
TLS3_k127_905344_5 Diguanylate cyclase K13069,K21021 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000171 244.0
TLS3_k127_905344_6 colicin V production K03558 - - 0.0000000000000000000000000000000000000000000001936 174.0
TLS3_k127_905344_7 Sporulation related domain K03749 - - 0.00000000000000000000000000000000000000000175 164.0
TLS3_k127_905344_8 Domain of unknown function (DUF4405) - - - 0.0000000000000000000000521 104.0
TLS3_k127_905344_9 - - - - 0.000000000007065 74.0
TLS3_k127_915817_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1071.0
TLS3_k127_915817_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 649.0
TLS3_k127_915817_2 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 526.0
TLS3_k127_915817_3 PpiC-type peptidyl-prolyl cis-trans isomerase K01802,K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 295.0
TLS3_k127_915817_4 NifZ domain K02597 - - 0.00000000000000000000000000000000000000000000000000000000005194 210.0
TLS3_k127_915817_5 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000000000001545 182.0
TLS3_k127_915817_6 Belongs to the UPF0125 (RnfH) family K09801 - - 0.00000000000000000000000000000000000000006707 152.0
TLS3_k127_915817_7 May protect the nitrogenase Fe-Mo protein from oxidative damage K02595 - - 0.000000000000000000000001388 107.0
TLS3_k127_915817_8 PFAM Haemerythrin HHE cation-binding motif K07216 - - 0.00000000000000004948 92.0
TLS3_k127_936763_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 422.0
TLS3_k127_936763_1 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000002541 164.0
TLS3_k127_936763_2 Phage integrase, N-terminal SAM-like domain - - - 0.000000000000000000000000000323 117.0
TLS3_k127_938245_0 metal-dependent phosphohydrolase HD sub domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 454.0
TLS3_k127_938245_1 Oxidoreductase FAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 413.0
TLS3_k127_938245_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 364.0
TLS3_k127_938245_3 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000121 236.0
TLS3_k127_938245_4 FHA domain - - - 0.000000000000000000000000000000000000000000000002898 182.0
TLS3_k127_938245_5 Diguanylate cyclase K21023 - 2.7.7.65 0.000000000000000001168 94.0
TLS3_k127_95040_0 Bacterial protein of unknown function (DUF853) K06915 - - 2.78e-234 734.0
TLS3_k127_95040_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 393.0
TLS3_k127_95040_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 362.0
TLS3_k127_95040_3 Cache domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006512 256.0
TLS3_k127_95040_4 Cyclic nucleotide-monophosphate binding domain K01420 - - 0.00000000000000000000000000000000000000000001427 171.0
TLS3_k127_95040_5 transcriptional regulatory protein - - - 0.0000000000000000000000000000002196 130.0
TLS3_k127_95040_6 - - - - 0.000000008418 64.0
TLS3_k127_954385_0 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.00000000000000000000000000000000000000001449 156.0
TLS3_k127_954385_1 Outer membrane protein V K07274 - - 0.000000000000000000000000000000002358 140.0
TLS3_k127_954385_2 helix_turn_helix ASNC type K03719 - - 0.00001502 48.0
TLS3_k127_958842_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 7.855e-237 739.0
TLS3_k127_958842_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 4.958e-207 649.0
TLS3_k127_958842_2 Heat shock 70 kDa protein K04043 - - 8.812e-201 630.0
TLS3_k127_958842_3 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000000000000000000000000002079 200.0
TLS3_k127_958842_4 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000001067 67.0
TLS3_k127_963081_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 473.0
TLS3_k127_963081_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 467.0
TLS3_k127_963081_2 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000008794 198.0
TLS3_k127_963081_3 - - - - 0.00000000000000000000000000000000000000000000009537 177.0
TLS3_k127_963081_4 - - - - 0.000000000000000000000000000000000000000002037 164.0
TLS3_k127_968010_0 recombinase XerD K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 381.0
TLS3_k127_968010_1 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008874 261.0
TLS3_k127_968010_2 COG0350 Methylated DNA-protein cysteine methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000009072 221.0
TLS3_k127_968010_3 TRAP transporter 4TM 12TM fusion - - - 0.0000000000000000000000000000000000000000000000000000000001113 207.0
TLS3_k127_968010_4 Domain of unknown function (DUF1850) - - - 0.00000000000000000000000000000000000000001512 163.0
TLS3_k127_968010_5 Transcriptional regulator, LysR family K13634 - - 0.0000000000000000000000000000846 117.0
TLS3_k127_987079_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 4.844e-244 775.0
TLS3_k127_987079_1 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 479.0
TLS3_k127_987079_2 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 470.0
TLS3_k127_987079_3 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 411.0
TLS3_k127_987079_4 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 366.0
TLS3_k127_987079_5 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000002458 109.0
TLS3_k127_987079_6 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.0000000003942 60.0
TLS3_k127_987079_7 PFAM Nucleotidyl transferase K00992 - 2.7.7.99 0.00000009579 63.0
TLS3_k127_988352_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 3.174e-297 919.0
TLS3_k127_988352_1 transcriptional K03719 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006338 262.0
TLS3_k127_988352_2 hydratase decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003632 270.0
TLS3_k127_988352_3 Related to nicotinamidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001171 262.0
TLS3_k127_988352_4 - - - - 0.000000000000000000000000000000000000000000000000001939 188.0
TLS3_k127_988352_5 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000004336 183.0
TLS3_k127_988352_6 Protein of unknown function (DUF2867) - - - 0.0000000000000003697 80.0
TLS3_k127_988352_7 cofactor biosynthesis protein NifB K02585 - - 0.00000001682 57.0