Overview

ID MAG04056
Name TLS3_bin.42
Sample SMP0105
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Blastocatellia
Order Pyrinomonadales
Family Pyrinomonadaceae
Genus PSRF01
Species
Assembly information
Completeness (%) 86.21
Contamination (%) 2.8
GC content (%) 54.0
N50 (bp) 19,238
Genome size (bp) 5,144,043

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3751

Gene name Description KEGG GOs EC E-value Score Sequence
TLS3_k127_102663_0 Type IV pilus assembly protein PilM; K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 311.0
TLS3_k127_102663_1 O-acyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000001349 244.0
TLS3_k127_102663_2 Secretin and TonB N terminus short domain K02666 - - 0.00000000000000000000000000000000000000000000000000000000000004698 237.0
TLS3_k127_102663_3 Roadblock/LC7 domain - - - 0.000000000000005108 79.0
TLS3_k127_102663_4 Pilus assembly protein, PilO K02664 - - 0.0000002359 60.0
TLS3_k127_1029558_0 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 385.0
TLS3_k127_1029558_1 MgtC family K07507 - - 0.0000000000000000000000000000000000000000000024 168.0
TLS3_k127_1047903_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 559.0
TLS3_k127_1047903_1 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 468.0
TLS3_k127_1047903_10 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000002676 224.0
TLS3_k127_1047903_11 Transport permease protein K09690 - - 0.000000000000000000000000000000000000000000000000000000000335 211.0
TLS3_k127_1047903_13 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000001992 194.0
TLS3_k127_1047903_14 Transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000000000004774 178.0
TLS3_k127_1047903_15 Cation transport regulator - - - 0.000000000000000000000000000000000000000000000005403 177.0
TLS3_k127_1047903_16 - - - - 0.00000000000000000000000000000000000000003838 174.0
TLS3_k127_1047903_17 DinB superfamily - - - 0.0000000000000000000000000000000000002278 148.0
TLS3_k127_1047903_18 - - - - 0.0000000000000000000000007537 104.0
TLS3_k127_1047903_19 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000005861 93.0
TLS3_k127_1047903_2 RmlD substrate binding domain K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 441.0
TLS3_k127_1047903_20 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000004645 80.0
TLS3_k127_1047903_21 CsbD-like - - - 0.00000000003233 65.0
TLS3_k127_1047903_22 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000005638 73.0
TLS3_k127_1047903_23 Zinc-dependent metalloprotease K07999 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016020,GO:0016787,GO:0019538,GO:0031224,GO:0031225,GO:0043170,GO:0044238,GO:0044425,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.0000000181 68.0
TLS3_k127_1047903_24 amine dehydrogenase activity - - - 0.00002416 58.0
TLS3_k127_1047903_3 Wzt C-terminal domain K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 380.0
TLS3_k127_1047903_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009562 354.0
TLS3_k127_1047903_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009444 336.0
TLS3_k127_1047903_6 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003973 307.0
TLS3_k127_1047903_7 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002225 273.0
TLS3_k127_1047903_8 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007335 264.0
TLS3_k127_1047903_9 Methionine biosynthesis protein MetW K18827 - 2.1.1.294,2.7.1.181 0.000000000000000000000000000000000000000000000000000000000000001555 239.0
TLS3_k127_1057284_0 MacB-like periplasmic core domain - - - 2.093e-294 925.0
TLS3_k127_1057284_1 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 525.0
TLS3_k127_1057284_2 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 417.0
TLS3_k127_1057284_3 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 342.0
TLS3_k127_1057284_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000003193 241.0
TLS3_k127_1057284_5 Clostripain family - - - 0.0000000000000000000000002262 122.0
TLS3_k127_1057284_6 Psort location Cytoplasmic, score - - - 0.000000000000007932 82.0
TLS3_k127_1057284_7 - - - - 0.00000000000126 78.0
TLS3_k127_1057284_9 Transposase IS200 like K07491 - - 0.00000002436 63.0
TLS3_k127_1066292_0 Tricorn protease C1 domain K08676 - - 0.0 1245.0
TLS3_k127_1066292_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 3.21e-239 756.0
TLS3_k127_1066292_10 PFAM Aminotransferase, class I K10907 - - 0.0000000000000000000000000000000000000000000000000000000000001779 229.0
TLS3_k127_1066292_11 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000004489 237.0
TLS3_k127_1066292_12 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000838 187.0
TLS3_k127_1066292_13 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000000000000007674 186.0
TLS3_k127_1066292_14 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000000000000007487 183.0
TLS3_k127_1066292_15 Transposase K07491 - - 0.000000000000000000000000000000000000000000002376 168.0
TLS3_k127_1066292_16 Ankyrin repeat - - - 0.0000000000000000000000001904 117.0
TLS3_k127_1066292_17 Response regulator receiver - - - 0.00000000000000000000002888 105.0
TLS3_k127_1066292_18 PFAM glycoside hydrolase, family 13 domain protein - - - 0.000000000008516 78.0
TLS3_k127_1066292_19 Putative zinc-finger - - - 0.0002001 48.0
TLS3_k127_1066292_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 615.0
TLS3_k127_1066292_20 Putative zinc-finger - - - 0.0007066 46.0
TLS3_k127_1066292_3 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 573.0
TLS3_k127_1066292_4 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000753 551.0
TLS3_k127_1066292_5 Domain of unknown function (DUF3471) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 532.0
TLS3_k127_1066292_6 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006721 394.0
TLS3_k127_1066292_7 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 355.0
TLS3_k127_1066292_8 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 339.0
TLS3_k127_1066292_9 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K17837 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000001384 279.0
TLS3_k127_1080847_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 5.584e-223 706.0
TLS3_k127_1080847_1 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 9.082e-197 644.0
TLS3_k127_1080847_10 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000001329 270.0
TLS3_k127_1080847_11 Bacterial extracellular solute-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002242 270.0
TLS3_k127_1080847_12 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000007402 265.0
TLS3_k127_1080847_13 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001447 278.0
TLS3_k127_1080847_14 ABC-type molybdate transport system, permease component K02018 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000003254 236.0
TLS3_k127_1080847_15 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000003041 229.0
TLS3_k127_1080847_16 PFAM pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000000000000000001325 200.0
TLS3_k127_1080847_17 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000001405 169.0
TLS3_k127_1080847_18 outer membrane autotransporter barrel domain protein - - - 0.00000000000000000000000000000000007499 142.0
TLS3_k127_1080847_19 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000005756 143.0
TLS3_k127_1080847_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 566.0
TLS3_k127_1080847_20 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.000000000000000000000126 105.0
TLS3_k127_1080847_21 - - - - 0.000000000007541 71.0
TLS3_k127_1080847_22 Pfam:N_methyl_2 - - - 0.0000000001881 62.0
TLS3_k127_1080847_23 Tetratricopeptide repeat - - - 0.00005446 55.0
TLS3_k127_1080847_3 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 498.0
TLS3_k127_1080847_4 phosphorelay signal transduction system K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 415.0
TLS3_k127_1080847_5 Type II secretion system (T2SS), protein F K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007682 400.0
TLS3_k127_1080847_6 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 384.0
TLS3_k127_1080847_7 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005402 326.0
TLS3_k127_1080847_8 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 301.0
TLS3_k127_1080847_9 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 301.0
TLS3_k127_1085070_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 612.0
TLS3_k127_1085070_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 470.0
TLS3_k127_11012_0 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 396.0
TLS3_k127_11012_1 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 377.0
TLS3_k127_11012_2 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 321.0
TLS3_k127_11012_3 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000003175 98.0
TLS3_k127_113485_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 5.112e-204 647.0
TLS3_k127_113485_1 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 504.0
TLS3_k127_113485_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 524.0
TLS3_k127_113485_3 acyl-CoA dehydrogenase activity K09456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000227 278.0
TLS3_k127_113485_4 peptidoglycan biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000001954 244.0
TLS3_k127_113485_5 DinB family - - - 0.0000000000000000000000000000000000000000001415 164.0
TLS3_k127_114940_0 hydrolase, family 3 K05349 - 3.2.1.21 4.843e-261 827.0
TLS3_k127_114940_1 Belongs to the glycosyl hydrolase 2 family - - - 6.406e-253 819.0
TLS3_k127_114940_2 xylose isomerase activity K01805 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 561.0
TLS3_k127_1159619_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 525.0
TLS3_k127_1159619_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 498.0
TLS3_k127_1159619_2 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 498.0
TLS3_k127_1159619_3 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 355.0
TLS3_k127_1159619_4 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 334.0
TLS3_k127_1159619_5 arsenate reductase (glutaredoxin) activity K00537 - 1.20.4.1 0.000000000000000000000000000000002128 131.0
TLS3_k127_1159619_6 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000002802 119.0
TLS3_k127_1164695_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001747 245.0
TLS3_k127_1164695_1 BON domain - - - 0.00000000000000000000000000000000000000000000000000000924 196.0
TLS3_k127_1164695_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000001022 111.0
TLS3_k127_1164695_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000003475 90.0
TLS3_k127_1190380_0 Tricorn protease C1 domain K08676 - - 0.0 1257.0
TLS3_k127_1190380_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1155.0
TLS3_k127_1190380_10 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 360.0
TLS3_k127_1190380_11 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 346.0
TLS3_k127_1190380_12 Aminotransferase class-V K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 343.0
TLS3_k127_1190380_13 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 299.0
TLS3_k127_1190380_14 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002231 293.0
TLS3_k127_1190380_15 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008369 284.0
TLS3_k127_1190380_16 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007001 273.0
TLS3_k127_1190380_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009105 270.0
TLS3_k127_1190380_18 FecR protein - - - 0.000000000000000000000000000000000000000000000000000000001537 225.0
TLS3_k127_1190380_19 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000007509 203.0
TLS3_k127_1190380_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.876e-260 822.0
TLS3_k127_1190380_20 Domain of unknown function (DUF1990) - - - 0.000000000000000000000000000000000000000000000000000754 189.0
TLS3_k127_1190380_21 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000003003 184.0
TLS3_k127_1190380_22 PFAM helix-turn-helix- domain containing protein, AraC type - - - 0.000000000000000000000000000000000000000000000001239 184.0
TLS3_k127_1190380_23 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000000001612 171.0
TLS3_k127_1190380_24 Protein of unknown function (DUF563) - - - 0.0000000000000000000000000000000000000000009467 170.0
TLS3_k127_1190380_25 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000004362 163.0
TLS3_k127_1190380_26 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000001319 150.0
TLS3_k127_1190380_27 acetyltransferase - - - 0.0000000000000000000000000000000000004912 144.0
TLS3_k127_1190380_28 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000001213 144.0
TLS3_k127_1190380_29 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000009281 130.0
TLS3_k127_1190380_3 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 570.0
TLS3_k127_1190380_30 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000001066 122.0
TLS3_k127_1190380_31 - - - - 0.00000000000000000000000000004068 121.0
TLS3_k127_1190380_32 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000008835 106.0
TLS3_k127_1190380_33 Redoxin - - - 0.000000000000000000002082 103.0
TLS3_k127_1190380_34 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000002446 87.0
TLS3_k127_1190380_35 von Willebrand factor type A domain - - - 0.0000000000008405 80.0
TLS3_k127_1190380_36 Ester cyclase K01061 - 3.1.1.45 0.0000000000008923 68.0
TLS3_k127_1190380_37 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000009332 54.0
TLS3_k127_1190380_39 SMART Transport-associated and nodulation region K04065 - - 0.000006107 54.0
TLS3_k127_1190380_4 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 556.0
TLS3_k127_1190380_5 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009651 529.0
TLS3_k127_1190380_6 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000669 489.0
TLS3_k127_1190380_7 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 411.0
TLS3_k127_1190380_8 PFAM TonB-dependent Receptor Plug - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 406.0
TLS3_k127_1190380_9 PFAM TonB-dependent Receptor Plug - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 389.0
TLS3_k127_1214226_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 488.0
TLS3_k127_1214226_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 448.0
TLS3_k127_1214226_2 NADH Ubiquinone plastoquinone (complex I) K05565 - - 0.0000000000000000000000000003493 118.0
TLS3_k127_1214226_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000003542 113.0
TLS3_k127_1232676_0 Sugar (and other) transporter - - - 2.376e-211 669.0
TLS3_k127_1232676_1 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 566.0
TLS3_k127_1232676_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 482.0
TLS3_k127_1232676_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009441 356.0
TLS3_k127_1232676_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000009793 134.0
TLS3_k127_1232676_5 RNA polymerase-associated protein CTR9 homolog K15176 GO:0000122,GO:0000428,GO:0000785,GO:0000993,GO:0001098,GO:0001099,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006479,GO:0006807,GO:0006996,GO:0008023,GO:0008150,GO:0008152,GO:0008213,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009909,GO:0009910,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010638,GO:0016020,GO:0016043,GO:0016569,GO:0016570,GO:0016571,GO:0016591,GO:0016593,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019219,GO:0019222,GO:0019538,GO:0019899,GO:0030880,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031399,GO:0031401,GO:0031974,GO:0031981,GO:0032259,GO:0032268,GO:0032270,GO:0032784,GO:0032786,GO:0032968,GO:0032991,GO:0033043,GO:0033044,GO:0034243,GO:0034968,GO:0035327,GO:0036211,GO:0043170,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044877,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048580,GO:0048581,GO:0048831,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051568,GO:0051569,GO:0051571,GO:0055029,GO:0060255,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0080182,GO:1901564,GO:1902275,GO:1902494,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1905269,GO:1990234,GO:2000026,GO:2000112,GO:2000113,GO:2000241,GO:2000242,GO:2001141,GO:2001252 - 0.00001939 57.0
TLS3_k127_1242212_0 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 556.0
TLS3_k127_1242212_1 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004773 502.0
TLS3_k127_1242212_10 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000000005686 205.0
TLS3_k127_1242212_11 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000000000000000000444 223.0
TLS3_k127_1242212_12 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000004739 180.0
TLS3_k127_1242212_13 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000001191 173.0
TLS3_k127_1242212_14 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.00000000000000000000000000000000000000007144 163.0
TLS3_k127_1242212_15 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000001776 163.0
TLS3_k127_1242212_16 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000002632 115.0
TLS3_k127_1242212_17 Disulphide bond corrector protein DsbC - - - 0.000000000003296 73.0
TLS3_k127_1242212_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03116,K03117 - - 0.00000000001282 70.0
TLS3_k127_1242212_19 PpiC-type peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.0002277 51.0
TLS3_k127_1242212_2 Peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 482.0
TLS3_k127_1242212_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 445.0
TLS3_k127_1242212_4 Peptidase M56 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 392.0
TLS3_k127_1242212_5 PFAM peptidase M19 renal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 330.0
TLS3_k127_1242212_6 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 318.0
TLS3_k127_1242212_7 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000282 289.0
TLS3_k127_1242212_8 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000376 222.0
TLS3_k127_1242212_9 surface antigen variable number - - - 0.000000000000000000000000000000000000000000000000000000000009347 237.0
TLS3_k127_1271991_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 456.0
TLS3_k127_1271991_1 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 403.0
TLS3_k127_1271991_2 - - - - 0.00000000000000000000000000245 112.0
TLS3_k127_1343031_0 ABC transporter transmembrane region K06147 - - 1.849e-207 667.0
TLS3_k127_1343031_1 pyrroloquinoline quinone binding K01206,K01218 - 3.2.1.51,3.2.1.78 2.092e-196 643.0
TLS3_k127_1343031_2 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002163 261.0
TLS3_k127_1343031_3 CHASE2 K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000009583 255.0
TLS3_k127_1343031_4 Popeye protein conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000002978 235.0
TLS3_k127_1343031_5 Leucine rich repeat - - - 0.000000000000000000000000000000000000000000000000000000000000001434 231.0
TLS3_k127_1343031_6 cell redox homeostasis - - - 0.000000000000000000000000000000000000000000000000002151 192.0
TLS3_k127_1343031_7 Crp-like helix-turn-helix domain K10914 - - 0.00000000008949 70.0
TLS3_k127_1363298_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.659e-201 634.0
TLS3_k127_1363298_1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 562.0
TLS3_k127_1363298_10 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000005119 238.0
TLS3_k127_1363298_11 beta-ketoacyl-acyl-carrier-protein synthase III activity K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000001106 243.0
TLS3_k127_1363298_12 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000000002294 196.0
TLS3_k127_1363298_13 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000001049 205.0
TLS3_k127_1363298_14 Thioredoxin reductase K00384,K03387 - 1.8.1.9 0.000000000000000000000000000000000000000000000003285 184.0
TLS3_k127_1363298_15 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000000000000000001015 173.0
TLS3_k127_1363298_16 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000001623 154.0
TLS3_k127_1363298_17 Radical SAM superfamily K22226 - - 0.0000000000000000000000000000000001933 145.0
TLS3_k127_1363298_18 Mo-molybdopterin cofactor metabolic process K03148,K03636,K21029,K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11 0.0000000000000000000000000005556 117.0
TLS3_k127_1363298_19 - - - - 0.000000000000000000000000001629 124.0
TLS3_k127_1363298_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 584.0
TLS3_k127_1363298_20 protein phosphatase 2C domain protein - - - 0.000000000000000000006716 110.0
TLS3_k127_1363298_21 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10794 - 1.21.4.1 0.0000000000000009982 87.0
TLS3_k127_1363298_22 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000006306 67.0
TLS3_k127_1363298_27 - - - - 0.00004593 55.0
TLS3_k127_1363298_3 - K00262 - 1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 464.0
TLS3_k127_1363298_4 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006073 462.0
TLS3_k127_1363298_5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 388.0
TLS3_k127_1363298_6 Gluconolactonase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 344.0
TLS3_k127_1363298_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 342.0
TLS3_k127_1363298_8 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001139 282.0
TLS3_k127_1363298_9 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001544 253.0
TLS3_k127_1391730_0 Peptidase family M49 - - - 4.12e-200 638.0
TLS3_k127_1391730_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 465.0
TLS3_k127_1391730_10 cell redox homeostasis K22278 - 3.5.1.104 0.0000000000000000000003374 111.0
TLS3_k127_1391730_11 Thioredoxin-like - - - 0.000000000000000000001329 108.0
TLS3_k127_1391730_12 Putative restriction endonuclease - - - 0.0000000000000000006259 88.0
TLS3_k127_1391730_13 PBS lyase HEAT-like repeat - - - 0.00000000000005981 84.0
TLS3_k127_1391730_14 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000002008 57.0
TLS3_k127_1391730_15 deoxyhypusine monooxygenase activity - - - 0.000048 56.0
TLS3_k127_1391730_16 Bacterial regulatory protein, Fis family K02584 - - 0.0005064 46.0
TLS3_k127_1391730_2 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 449.0
TLS3_k127_1391730_3 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007243 433.0
TLS3_k127_1391730_4 Aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 424.0
TLS3_k127_1391730_5 3'(2'),5'-bisphosphate nucleotidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009905 356.0
TLS3_k127_1391730_6 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 299.0
TLS3_k127_1391730_7 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 292.0
TLS3_k127_1391730_8 Cytochrome C biogenesis protein transmembrane region K06196,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000002301 203.0
TLS3_k127_1391730_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000001229 143.0
TLS3_k127_1398741_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 407.0
TLS3_k127_1398741_1 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000051 272.0
TLS3_k127_1398741_2 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000001742 217.0
TLS3_k127_1398741_4 - - - - 0.000003976 60.0
TLS3_k127_140780_0 Two component regulator propeller - - - 4.424e-264 844.0
TLS3_k127_140780_1 ATP dependent DNA ligase C terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 558.0
TLS3_k127_140780_2 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007734 265.0
TLS3_k127_140780_3 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 - 1.13.11.53,1.13.11.54 0.00000000000000000000000000000000000000000000000000000000000000000009638 235.0
TLS3_k127_140780_4 Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) K09880 - 3.1.3.77 0.0000000000000000000000000000000000000000000000000000000000000004562 227.0
TLS3_k127_140780_5 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) K08964 - 4.2.1.109 0.000000000000000000000000000000000000000000000000000003096 197.0
TLS3_k127_140780_6 Transposase IS200 like - - - 0.0000000000000000002999 95.0
TLS3_k127_140780_7 Protein of unknown function (DUF433) - - - 0.000002831 53.0
TLS3_k127_140780_8 Cro/C1-type HTH DNA-binding domain - - - 0.0003371 47.0
TLS3_k127_144179_0 AbgT putative transporter family K12942 - - 2.397e-204 651.0
TLS3_k127_144179_1 Multicopper oxidase K14588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 419.0
TLS3_k127_144179_2 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 360.0
TLS3_k127_144179_3 SCO1/SenC - - - 0.000000000000000000000000000000000000000000000000000000002512 207.0
TLS3_k127_144179_4 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000001713 197.0
TLS3_k127_144179_5 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000000001776 181.0
TLS3_k127_144179_6 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000859 167.0
TLS3_k127_144226_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000003333 215.0
TLS3_k127_144226_1 Sulfatase-modifying factor enzyme 1 K20333 - - 0.000000000000000000000000001665 130.0
TLS3_k127_1470490_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007028 402.0
TLS3_k127_1470490_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000127 312.0
TLS3_k127_1470490_2 Belongs to the peptidase S8 family K14645 - - 0.0000000000000000000000000000000000000000000000000000000000001547 221.0
TLS3_k127_1470490_3 PFAM TPR repeat-containing protein - - - 0.000000000000000000000000000000000000000002749 181.0
TLS3_k127_1470490_4 3',5'-cyclic-GMP phosphodiesterase activity K18283 - 3.1.4.17 0.0000000006546 70.0
TLS3_k127_149005_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 4.667e-203 649.0
TLS3_k127_149005_1 Tetratricopeptide repeat - - - 8.135e-197 651.0
TLS3_k127_149005_10 Sigma-70, region 4 K03088 - - 0.00026 50.0
TLS3_k127_149005_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007551 550.0
TLS3_k127_149005_3 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 451.0
TLS3_k127_149005_4 pfkB family carbohydrate kinase K18478 - 2.7.1.184 0.0000000000000000000000000000000000000000000000000000000000000000001899 240.0
TLS3_k127_149005_5 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000006996 237.0
TLS3_k127_149005_6 Clostripain family - - - 0.00000000000000000000000000000000000000000222 175.0
TLS3_k127_149005_7 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000007143 152.0
TLS3_k127_149005_8 von Willebrand factor, type A - - - 0.000000000000000000000000008435 121.0
TLS3_k127_149005_9 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.0000000000239 74.0
TLS3_k127_1500897_0 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000000003942 60.0
TLS3_k127_1500897_1 - - - - 0.0000003109 63.0
TLS3_k127_1500897_2 Domain of unknown function (DUF4388) - - - 0.000001043 60.0
TLS3_k127_1500897_3 TPR repeat - - - 0.000005252 59.0
TLS3_k127_1526668_0 Multicopper oxidase - - - 0.0 1305.0
TLS3_k127_1526668_1 dna ligase - - - 2.781e-227 709.0
TLS3_k127_1526668_10 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000115 147.0
TLS3_k127_1526668_11 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000662 77.0
TLS3_k127_1526668_12 - - - - 0.0000005363 57.0
TLS3_k127_1526668_13 cell adhesion involved in biofilm formation - - - 0.00006409 51.0
TLS3_k127_1526668_14 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.0002437 51.0
TLS3_k127_1526668_2 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 524.0
TLS3_k127_1526668_3 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 442.0
TLS3_k127_1526668_4 H( )-stimulated, divalent metal cation uptake system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 402.0
TLS3_k127_1526668_5 Amino acid kinase family K00928,K12524 - 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000001201 237.0
TLS3_k127_1526668_6 SCO1/SenC K07152,K08976 - - 0.0000000000000000000000000000000000000000000000000000004213 201.0
TLS3_k127_1526668_7 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000002242 191.0
TLS3_k127_1526668_8 SCO1 SenC K07152 - - 0.00000000000000000000000000000000000000000000003051 179.0
TLS3_k127_1526668_9 PFAM glycosyl transferase family 25 K07270 - - 0.000000000000000000000000000000000000000000003483 178.0
TLS3_k127_1550197_0 Belongs to the ClpA ClpB family K03696 - - 0.0 1076.0
TLS3_k127_1550197_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 512.0
TLS3_k127_1550197_10 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000007181 267.0
TLS3_k127_1550197_11 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000001999 242.0
TLS3_k127_1550197_12 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000002157 229.0
TLS3_k127_1550197_13 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000004742 199.0
TLS3_k127_1550197_14 FabA-like domain K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000001138 179.0
TLS3_k127_1550197_15 Histidine kinase-like ATPase domain - - - 0.00000000000000000000000000000000000001937 155.0
TLS3_k127_1550197_16 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.00000000000000000000000000000000323 131.0
TLS3_k127_1550197_17 TPM domain K06872 - - 0.000000000002858 81.0
TLS3_k127_1550197_18 Outer membrane protein (OmpH-like) K06142 - - 0.0000001334 61.0
TLS3_k127_1550197_19 PFAM Tetratricopeptide repeat - - - 0.0000001745 65.0
TLS3_k127_1550197_2 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 469.0
TLS3_k127_1550197_20 Outer membrane protein (OmpH-like) K06142 - - 0.0000006333 59.0
TLS3_k127_1550197_21 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0003568 53.0
TLS3_k127_1550197_3 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 446.0
TLS3_k127_1550197_4 PFAM Alanine dehydrogenase PNT, C-terminal domain K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 384.0
TLS3_k127_1550197_5 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 354.0
TLS3_k127_1550197_6 Protein of unknown function (DUF1009) K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 311.0
TLS3_k127_1550197_7 PFAM Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 316.0
TLS3_k127_1550197_8 Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 307.0
TLS3_k127_1550197_9 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 293.0
TLS3_k127_1575290_0 PFAM carbohydrate kinase K00854 - 2.7.1.17 3.47e-216 680.0
TLS3_k127_1575290_1 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 604.0
TLS3_k127_1575290_2 DinB family - - - 0.0000000000000000000000000000000000000000000000006665 183.0
TLS3_k127_1575290_3 FHIPEP family K03230 - - 0.00000000000000000000000000000000000000006076 176.0
TLS3_k127_1575290_4 histone H2A K63-linked ubiquitination - - - 0.0000000000000000000000000000000005707 150.0
TLS3_k127_1575290_5 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.00000000000000001274 99.0
TLS3_k127_1575290_6 PBS lyase HEAT-like repeat - - - 0.000000000000001474 91.0
TLS3_k127_1575290_7 O-linked N-acetylglucosamine transferase SPINDLY family - - - 0.0000000000000847 87.0
TLS3_k127_158329_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1227.0
TLS3_k127_158329_1 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004902 562.0
TLS3_k127_158329_10 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000001217 169.0
TLS3_k127_158329_11 von Willebrand factor, type A - - - 0.000000000000000000000000000000005479 142.0
TLS3_k127_158329_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000005051 141.0
TLS3_k127_158329_13 Psort location Cytoplasmic, score - - - 0.000000000000000000000000003256 113.0
TLS3_k127_158329_14 - - - - 0.00000000000000000000000005838 124.0
TLS3_k127_158329_15 acetyltransferase - - - 0.0000000000000001301 94.0
TLS3_k127_158329_16 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000001265 78.0
TLS3_k127_158329_17 Belongs to the 'phage' integrase family K04763 - - 0.00003714 49.0
TLS3_k127_158329_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 494.0
TLS3_k127_158329_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 440.0
TLS3_k127_158329_4 Methylase involved in ubiquinone menaquinone K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 389.0
TLS3_k127_158329_5 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 327.0
TLS3_k127_158329_6 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 309.0
TLS3_k127_158329_7 Nucleotidyl transferase AbiEii toxin, Type IV TA system K09144 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 307.0
TLS3_k127_158329_8 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000001312 202.0
TLS3_k127_158329_9 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000002707 205.0
TLS3_k127_158368_0 Amidohydrolase family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 538.0
TLS3_k127_158368_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004293 258.0
TLS3_k127_158368_2 palmitoyl-(protein) hydrolase activity K06999 - - 0.00000000000000000000000000004174 126.0
TLS3_k127_158368_3 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000001512 103.0
TLS3_k127_158372_0 Associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 370.0
TLS3_k127_158372_1 cell adhesion involved in biofilm formation K02014,K11031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001366 263.0
TLS3_k127_158372_2 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000003571 251.0
TLS3_k127_158372_3 Domain of unknown function (DUF4350) - - - 0.0000000000001779 83.0
TLS3_k127_158372_4 Domain of unknown function (DUF4129) - - - 0.0000001384 63.0
TLS3_k127_158372_5 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000004936 61.0
TLS3_k127_158372_6 Anaphase-promoting complex, cyclosome, subunit 3 K09561 GO:0000151,GO:0000209,GO:0001664,GO:0001666,GO:0002931,GO:0003674,GO:0003824,GO:0004842,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006457,GO:0006464,GO:0006508,GO:0006511,GO:0006515,GO:0006807,GO:0006950,GO:0006986,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009894,GO:0009896,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010498,GO:0010604,GO:0010646,GO:0010648,GO:0010817,GO:0012505,GO:0016234,GO:0016567,GO:0016740,GO:0017015,GO:0019216,GO:0019218,GO:0019222,GO:0019538,GO:0019787,GO:0019899,GO:0019900,GO:0019904,GO:0019941,GO:0023051,GO:0023052,GO:0023057,GO:0030016,GO:0030017,GO:0030018,GO:0030162,GO:0030163,GO:0030433,GO:0030512,GO:0030544,GO:0030579,GO:0030674,GO:0030911,GO:0030968,GO:0031072,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0031334,GO:0031371,GO:0031396,GO:0031398,GO:0031399,GO:0031401,GO:0031625,GO:0031647,GO:0031674,GO:0031943,GO:0031974,GO:0031981,GO:0032091,GO:0032268,GO:0032270,GO:0032350,GO:0032434,GO:0032436,GO:0032446,GO:0032991,GO:0033554,GO:0034450,GO:0034605,GO:0034620,GO:0034976,GO:0035966,GO:0035967,GO:0036211,GO:0036293,GO:0036294,GO:0036503,GO:0042176,GO:0042221,GO:0042405,GO:0042802,GO:0042803,GO:0043085,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043292,GO:0043393,GO:0043412,GO:0043632,GO:0044087,GO:0044089,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0045732,GO:0045862,GO:0046332,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051087,GO:0051098,GO:0051100,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0051438,GO:0051443,GO:0051603,GO:0051604,GO:0051716,GO:0051787,GO:0051788,GO:0051865,GO:0051879,GO:0060090,GO:0060255,GO:0061136,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070482,GO:0070534,GO:0070647,GO:0070887,GO:0071218,GO:0071310,GO:0071453,GO:0071456,GO:0071704,GO:0080090,GO:0090034,GO:0090035,GO:0090092,GO:0090101,GO:0090287,GO:0090288,GO:0099080,GO:0099081,GO:0099512,GO:0101031,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903320,GO:1903322,GO:1903362,GO:1903364,GO:1903844,GO:1903845,GO:1990234,GO:2000058,GO:2000060 2.3.2.27 0.00009502 54.0
TLS3_k127_1626273_0 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 516.0
TLS3_k127_1626273_1 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 392.0
TLS3_k127_1626273_10 Cell wall-associated hydrolase, invasion-associated protein K21471 GO:0005575,GO:0005576 - 0.00000000003399 72.0
TLS3_k127_1626273_2 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008811 380.0
TLS3_k127_1626273_3 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000001092 226.0
TLS3_k127_1626273_4 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000004394 187.0
TLS3_k127_1626273_5 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000002762 136.0
TLS3_k127_1626273_6 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000006439 111.0
TLS3_k127_1626273_7 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000000003592 78.0
TLS3_k127_1626273_8 Lipopolysaccharide-assembly - - - 0.000000000000006788 81.0
TLS3_k127_1626273_9 - - - - 0.000000000003621 71.0
TLS3_k127_1663351_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 582.0
TLS3_k127_1663351_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 453.0
TLS3_k127_1663351_2 HxlR-like helix-turn-helix - - - 0.00000000000000003882 83.0
TLS3_k127_1695672_0 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 495.0
TLS3_k127_1695672_1 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 432.0
TLS3_k127_1695672_2 Male sterility protein K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 406.0
TLS3_k127_1695672_3 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 342.0
TLS3_k127_1695672_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000001259 207.0
TLS3_k127_1695672_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000005447 180.0
TLS3_k127_1695672_6 Domain of unknown function (DUF5011) - - - 0.000000000000001152 91.0
TLS3_k127_1707435_0 domain protein K14194 - - 0.0000000000000003536 92.0
TLS3_k127_1707435_1 domain protein K14194 - - 0.000000000007145 78.0
TLS3_k127_1715099_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007669 605.0
TLS3_k127_1715099_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 514.0
TLS3_k127_1715099_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 440.0
TLS3_k127_1715099_3 endonuclease III - - - 0.0000000000000000000000000000000000000000000000000000000000004 218.0
TLS3_k127_1715099_4 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000004303 65.0
TLS3_k127_1727209_0 Multicopper oxidase - - - 0.0 1748.0
TLS3_k127_1727209_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.211e-237 742.0
TLS3_k127_1727209_10 SCO1/SenC K07152,K08976 - - 0.000000000000000000000000000000000000000000000000000003806 202.0
TLS3_k127_1727209_11 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000002253 143.0
TLS3_k127_1727209_12 RNA recognition motif - - - 0.00000000000000000000000000003608 121.0
TLS3_k127_1727209_13 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000003572 104.0
TLS3_k127_1727209_14 - - - - 0.0000000006291 61.0
TLS3_k127_1727209_15 Periplasmic or secreted lipoprotein - - - 0.00004259 57.0
TLS3_k127_1727209_16 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0002197 47.0
TLS3_k127_1727209_17 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K02005 - - 0.0007773 51.0
TLS3_k127_1727209_2 alpha-L-arabinofuranosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 608.0
TLS3_k127_1727209_3 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 561.0
TLS3_k127_1727209_4 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 474.0
TLS3_k127_1727209_5 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 426.0
TLS3_k127_1727209_6 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009494 409.0
TLS3_k127_1727209_7 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006141 360.0
TLS3_k127_1727209_8 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001148 249.0
TLS3_k127_1727209_9 SCO1/SenC K07152,K08976 - - 0.0000000000000000000000000000000000000000000000000000000000001097 219.0
TLS3_k127_1731767_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 8.999e-200 646.0
TLS3_k127_1731767_1 UDP binding domain K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 553.0
TLS3_k127_1731767_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 374.0
TLS3_k127_1731767_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002245 261.0
TLS3_k127_1731767_4 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000001936 232.0
TLS3_k127_1744002_0 metalloendopeptidase activity K01283 - 3.4.15.1 1.763e-252 792.0
TLS3_k127_1744002_1 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 460.0
TLS3_k127_1744002_2 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 359.0
TLS3_k127_1744002_3 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002237 255.0
TLS3_k127_1744002_4 helix_turn_helix gluconate operon transcriptional repressor K07978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007011 249.0
TLS3_k127_1744002_5 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000004923 186.0
TLS3_k127_1744002_6 transposition - - - 0.00000000000000000000000000000000000000000003415 163.0
TLS3_k127_1744002_7 metal cluster binding - - - 0.00000000000000000000000000000000000000000163 163.0
TLS3_k127_1744002_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000008916 126.0
TLS3_k127_1744002_9 Iron-binding zinc finger CDGSH type - - - 0.00000000000000000000002218 109.0
TLS3_k127_1766555_0 cellulose binding - - - 0.0 1318.0
TLS3_k127_1766555_1 Domain of unknown function (DUF5117) - - - 1.503e-300 942.0
TLS3_k127_1766555_10 RHS Repeat - - - 0.00000595 61.0
TLS3_k127_1766555_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 413.0
TLS3_k127_1766555_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000003175 261.0
TLS3_k127_1766555_4 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000001485 259.0
TLS3_k127_1766555_5 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003974 274.0
TLS3_k127_1766555_6 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001429 267.0
TLS3_k127_1766555_7 - - - - 0.00000000000000000000000000000000000001817 149.0
TLS3_k127_1766555_8 Protein conserved in bacteria - - - 0.000000000000001192 80.0
TLS3_k127_1766555_9 COG3209 Rhs family protein - - - 0.00000000244 72.0
TLS3_k127_1770375_0 COG3209 Rhs family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 328.0
TLS3_k127_1770375_1 Integrase core domain K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004169 241.0
TLS3_k127_1770375_2 COG3209 Rhs family protein - - - 0.000000000000000000000000001535 133.0
TLS3_k127_1770375_3 transposase activity K07483,K07497 - - 0.00000005527 57.0
TLS3_k127_1770375_4 isoform X1 - - - 0.0000003741 65.0
TLS3_k127_1770375_5 TIR domain - - - 0.000006978 48.0
TLS3_k127_1770375_7 G8 - - - 0.0001567 57.0
TLS3_k127_1781177_0 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 395.0
TLS3_k127_1781177_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 355.0
TLS3_k127_1781177_2 YHS domain K06966 - 3.2.2.10 0.000000000000000000000000000000000002927 143.0
TLS3_k127_1788795_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.00000000000000000000000000000002032 141.0
TLS3_k127_1788795_1 Bacterial regulatory protein, Fis family - - - 0.00000000000004652 84.0
TLS3_k127_1788795_2 sequence-specific DNA binding - - - 0.000001554 55.0
TLS3_k127_1789038_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 558.0
TLS3_k127_1789038_1 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 415.0
TLS3_k127_1789038_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000005412 271.0
TLS3_k127_1789038_3 Imidazoleglycerol-phosphate dehydratase K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000001611 229.0
TLS3_k127_1789038_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000009948 224.0
TLS3_k127_1789038_5 Ecdysteroid kinase - - - 0.00000000000000000000000000000000000000000000000000000000000021 225.0
TLS3_k127_1789038_6 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000001947 184.0
TLS3_k127_1789038_7 - - - - 0.0000000000000000000000000000000000008272 149.0
TLS3_k127_1789038_8 RNA polymerase, sigma-24 subunit, ECF subfamily K02405 - - 0.00000000000000000000000000000000000915 143.0
TLS3_k127_1789038_9 - - - - 0.0000001177 61.0
TLS3_k127_1805566_0 Dienelactone hydrolase family - - - 4.233e-314 984.0
TLS3_k127_1805566_1 Carboxypeptidase regulatory-like domain - - - 1.591e-264 848.0
TLS3_k127_1805566_10 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 535.0
TLS3_k127_1805566_11 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 533.0
TLS3_k127_1805566_12 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 525.0
TLS3_k127_1805566_13 COG NOG10142 non supervised orthologous group - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 489.0
TLS3_k127_1805566_14 ABC transporter K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 466.0
TLS3_k127_1805566_15 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 442.0
TLS3_k127_1805566_16 transcription factor binding K15836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 460.0
TLS3_k127_1805566_17 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005158 428.0
TLS3_k127_1805566_18 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007787 427.0
TLS3_k127_1805566_19 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 416.0
TLS3_k127_1805566_2 serine dehydratase beta chain K01752 - 4.3.1.17 1.182e-254 795.0
TLS3_k127_1805566_20 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007038 402.0
TLS3_k127_1805566_21 Protein of unknown function (DUF2950) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 383.0
TLS3_k127_1805566_22 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 347.0
TLS3_k127_1805566_23 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 312.0
TLS3_k127_1805566_24 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 282.0
TLS3_k127_1805566_25 MotA TolQ ExbB proton channel K03561,K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001104 267.0
TLS3_k127_1805566_26 Conserved Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001385 241.0
TLS3_k127_1805566_27 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000001585 245.0
TLS3_k127_1805566_28 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000967 226.0
TLS3_k127_1805566_29 Histidine kinase K07683 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000006136 225.0
TLS3_k127_1805566_3 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.141e-247 784.0
TLS3_k127_1805566_30 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000001265 207.0
TLS3_k127_1805566_31 - - - - 0.000000000000000000000000000000000000000000000000000006983 203.0
TLS3_k127_1805566_32 Domain of unknown function (DUF4136) - - - 0.0000000000000000000000000000000000000000000000000005741 190.0
TLS3_k127_1805566_33 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000005791 176.0
TLS3_k127_1805566_35 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000002743 160.0
TLS3_k127_1805566_36 chlorophyll binding - - - 0.0000000000000000000000000000000000000217 156.0
TLS3_k127_1805566_37 - - - - 0.0000000000000000000000000000000001074 143.0
TLS3_k127_1805566_38 cheY-homologous receiver domain - - - 0.0000000000000000000000000000267 121.0
TLS3_k127_1805566_39 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000001146 106.0
TLS3_k127_1805566_4 peroxidase - - - 3.236e-224 701.0
TLS3_k127_1805566_40 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000001582 93.0
TLS3_k127_1805566_41 Preprotein translocase, YajC subunit K03210 - - 0.00000000000000000002765 93.0
TLS3_k127_1805566_42 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 0.0000000000000002747 91.0
TLS3_k127_1805566_43 TIGRFAM TonB K03832 - - 0.0000000000000004381 88.0
TLS3_k127_1805566_44 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000000001048 83.0
TLS3_k127_1805566_45 Belongs to the UPF0102 family K07460 - - 0.00000000000001982 79.0
TLS3_k127_1805566_46 Tetratricopeptide repeat - - - 0.00000000000003868 82.0
TLS3_k127_1805566_48 RDD family - - - 0.000000001694 61.0
TLS3_k127_1805566_49 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.0000003245 57.0
TLS3_k127_1805566_5 Tfp pilus assembly protein FimV - - - 3.433e-213 676.0
TLS3_k127_1805566_50 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.00002173 54.0
TLS3_k127_1805566_51 monooxygenase - GO:0003674,GO:0003824 - 0.0000386 51.0
TLS3_k127_1805566_52 GAF domain K21405 - - 0.0001411 45.0
TLS3_k127_1805566_6 Amidase K01426 - 3.5.1.4 4.883e-196 625.0
TLS3_k127_1805566_7 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007683 565.0
TLS3_k127_1805566_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 541.0
TLS3_k127_1805566_9 Belongs to the glutaminase family K01425 - 3.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 533.0
TLS3_k127_180619_0 NADH oxidase - - - 3.735e-210 662.0
TLS3_k127_180619_1 Aminotransferase class-V K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004051 458.0
TLS3_k127_180619_10 Thioredoxin-like K06196 - - 0.000000005908 64.0
TLS3_k127_180619_2 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 366.0
TLS3_k127_180619_3 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 362.0
TLS3_k127_180619_4 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008498 297.0
TLS3_k127_180619_5 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000002752 236.0
TLS3_k127_180619_6 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000003845 213.0
TLS3_k127_180619_7 - - - - 0.00000000000000000000000000000000000000002339 159.0
TLS3_k127_180619_8 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000001484 131.0
TLS3_k127_180619_9 PFAM HD domain - - - 0.0000000000000000000000000000006151 130.0
TLS3_k127_180633_0 Putative glucoamylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 572.0
TLS3_k127_180633_1 Beta-xylosidase K01198 - 3.2.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 577.0
TLS3_k127_180633_10 Lysine methyltransferase - - - 0.0000000000000000000000000000000000001311 152.0
TLS3_k127_180633_12 COGs COG1033 exporter of the RND superfamily protein K07003 - - 0.00000000000000006966 85.0
TLS3_k127_180633_2 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 464.0
TLS3_k127_180633_3 dioxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 424.0
TLS3_k127_180633_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 387.0
TLS3_k127_180633_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 308.0
TLS3_k127_180633_6 Peptidase family S51 K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000041 289.0
TLS3_k127_180633_7 Putative lumazine-binding - - - 0.000000000000000000000000000000000000000000000000003203 185.0
TLS3_k127_180633_8 SnoaL-like domain K06893 - - 0.0000000000000000000000000000000000000000000005932 169.0
TLS3_k127_180633_9 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000000000000005427 155.0
TLS3_k127_1815495_0 Domain of unknown function (DUF5117) - - - 8.171e-320 1001.0
TLS3_k127_1815495_1 aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001868 288.0
TLS3_k127_1815495_2 PFAM Peptidase family M23 K21472 - - 0.00000000000000000000000000000000000000000000000002892 186.0
TLS3_k127_1832351_0 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006962 456.0
TLS3_k127_183240_0 Dipeptidyl peptidase IV (DPP IV) K01278 - 3.4.14.5 5.564e-292 916.0
TLS3_k127_183240_1 transferase activity, transferring acyl groups K14658,K17840,K18815 - 2.3.1.59,2.3.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 643.0
TLS3_k127_183240_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 476.0
TLS3_k127_183818_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 2.905e-199 631.0
TLS3_k127_183818_1 PFAM Beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 576.0
TLS3_k127_183818_2 Sodium/hydrogen exchanger family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 471.0
TLS3_k127_183818_3 dioxygenase K15777 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0046566,GO:0051213,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006122 392.0
TLS3_k127_183818_4 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.000000000000000000000000000000000000000000000001154 182.0
TLS3_k127_183818_5 Universal stress protein family K07090 - - 0.00000000000000001006 93.0
TLS3_k127_183818_6 Suppressor of fused protein (SUFU) - - - 0.00000002854 62.0
TLS3_k127_183823_0 STAS domain K04749 - - 0.000000000000000000000000002514 117.0
TLS3_k127_183823_1 - - - - 0.0000006305 55.0
TLS3_k127_183823_2 response regulator K02481,K07713 - - 0.000001383 55.0
TLS3_k127_1845874_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 541.0
TLS3_k127_1845874_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 502.0
TLS3_k127_1845874_10 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002944 269.0
TLS3_k127_1845874_11 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001803 279.0
TLS3_k127_1845874_12 Copper binding periplasmic protein CusF K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003268 257.0
TLS3_k127_1845874_13 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000766 176.0
TLS3_k127_1845874_14 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000001259 124.0
TLS3_k127_1845874_15 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.0000000000000000000000000000163 137.0
TLS3_k127_1845874_16 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000001345 110.0
TLS3_k127_1845874_17 Ribosomal L32p protein family K02911 - - 0.000000000000000000002139 94.0
TLS3_k127_1845874_18 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000004022 68.0
TLS3_k127_1845874_19 peptidyl-tyrosine sulfation - - - 0.000000008256 67.0
TLS3_k127_1845874_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain II K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 409.0
TLS3_k127_1845874_20 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0009645 43.0
TLS3_k127_1845874_3 Dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 383.0
TLS3_k127_1845874_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 371.0
TLS3_k127_1845874_5 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 361.0
TLS3_k127_1845874_6 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 359.0
TLS3_k127_1845874_7 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 340.0
TLS3_k127_1845874_8 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008686 334.0
TLS3_k127_1845874_9 PFAM transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 307.0
TLS3_k127_1847232_0 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 614.0
TLS3_k127_1847232_1 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000005371 228.0
TLS3_k127_1847232_2 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000003053 212.0
TLS3_k127_1847232_3 PFAM Response regulator receiver domain K07713 - - 0.000000000000000000000000000000000000000000000000000003531 201.0
TLS3_k127_1847232_4 Pyridine nucleotide-disulphide oxidoreductase K03885,K17218 - 1.6.99.3,1.8.5.4 0.000000000000000000000000000000000000000000000000004966 195.0
TLS3_k127_1847232_5 Universal stress protein family - - - 0.0000000000000000000000000000002461 130.0
TLS3_k127_1847232_6 cyclic nucleotide-binding K10914 - - 0.00000000000000000000000007091 116.0
TLS3_k127_1847232_7 AMP binding - - - 0.000000000000001862 87.0
TLS3_k127_1847232_8 Belongs to the universal stress protein A family - - - 0.00000001252 66.0
TLS3_k127_1847232_9 Universal stress protein - - - 0.000293 51.0
TLS3_k127_1853072_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.004e-218 690.0
TLS3_k127_1853072_1 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 338.0
TLS3_k127_1853072_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007942 325.0
TLS3_k127_1853072_3 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000176 252.0
TLS3_k127_1853072_4 Cytidylyltransferase K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000006199 214.0
TLS3_k127_1853072_5 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000002485 184.0
TLS3_k127_1853261_0 Sulfatase K01130 - 3.1.6.1 0.0 1290.0
TLS3_k127_1853261_1 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003724 473.0
TLS3_k127_1853261_10 - - - - 0.0000000000000000000265 95.0
TLS3_k127_1853261_11 - - - - 0.0000000000000001567 81.0
TLS3_k127_1853261_12 Putative MetA-pathway of phenol degradation - - - 0.000683 47.0
TLS3_k127_1853261_13 surface antigen - - - 0.0008836 48.0
TLS3_k127_1853261_2 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 293.0
TLS3_k127_1853261_3 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000116 263.0
TLS3_k127_1853261_4 long-chain fatty acid transport protein - - - 0.00000000000000000000000000000000000000000000005248 181.0
TLS3_k127_1853261_5 Protein of unknown function (DUF2490) - - - 0.00000000000000000000000000000007053 134.0
TLS3_k127_1853261_6 Predicted periplasmic protein (DUF2092) - - - 0.0000000000000000000000000000001361 135.0
TLS3_k127_1853261_7 phosphorelay signal transduction system K14987 - - 0.00000000000000000000000001487 119.0
TLS3_k127_1853261_8 phosphorelay signal transduction system K14987 - - 0.000000000000000000000001133 110.0
TLS3_k127_1853261_9 - - - - 0.00000000000000000001041 95.0
TLS3_k127_1856018_0 Peptidase S46 - - - 4.527e-233 743.0
TLS3_k127_186124_0 lipopolysaccharide transport K22110 - - 0.0 1389.0
TLS3_k127_186124_1 choline dehydrogenase activity - - - 7.183e-261 811.0
TLS3_k127_186124_2 gluconolactonase activity K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 594.0
TLS3_k127_186124_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 466.0
TLS3_k127_186124_4 Cupin 2, conserved barrel domain protein K11477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008211 355.0
TLS3_k127_186124_5 Major intrinsic protein K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 308.0
TLS3_k127_186124_6 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000001179 175.0
TLS3_k127_186203_0 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 526.0
TLS3_k127_186203_1 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 415.0
TLS3_k127_186203_2 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004148 292.0
TLS3_k127_186203_3 PFAM response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000001136 108.0
TLS3_k127_1864231_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 506.0
TLS3_k127_1864231_1 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008704 430.0
TLS3_k127_1864231_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 341.0
TLS3_k127_1864231_3 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000001747 185.0
TLS3_k127_1864231_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000429 157.0
TLS3_k127_1864231_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000001222 158.0
TLS3_k127_1864231_6 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000000000222 133.0
TLS3_k127_1864231_7 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K00340 - 1.6.5.3 0.00000000000000000000000000005161 120.0
TLS3_k127_1864231_8 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000094 113.0
TLS3_k127_190580_0 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 394.0
TLS3_k127_190580_1 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004843 256.0
TLS3_k127_190580_2 hydroperoxide reductase activity - - - 0.000000000000000000000005144 104.0
TLS3_k127_190580_3 Transglycosylase associated protein - - - 0.000000000000000000007153 94.0
TLS3_k127_1918994_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 458.0
TLS3_k127_1918994_1 ThiF family K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007996 370.0
TLS3_k127_1918994_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 309.0
TLS3_k127_1918994_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001182 256.0
TLS3_k127_1918994_4 RNA 2'-O ribose methyltransferase substrate binding K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000002539 246.0
TLS3_k127_1918994_5 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000002406 246.0
TLS3_k127_1918994_6 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002202 229.0
TLS3_k127_1918994_7 COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K10126 - - 0.00005114 50.0
TLS3_k127_1922006_0 extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003704 276.0
TLS3_k127_1922006_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000009938 237.0
TLS3_k127_1922006_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000002861 175.0
TLS3_k127_1922006_3 PFAM Class III cytochrome C family - - - 0.0003029 50.0
TLS3_k127_1922006_4 adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0003711 53.0
TLS3_k127_192989_0 Radical SAM - - - 5.262e-220 700.0
TLS3_k127_192989_1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 318.0
TLS3_k127_192989_2 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 295.0
TLS3_k127_192989_3 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 297.0
TLS3_k127_192989_4 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000001735 237.0
TLS3_k127_192989_5 GAF domain K02482 - 2.7.13.3 0.0000006531 55.0
TLS3_k127_1931761_0 protease with the C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005504 507.0
TLS3_k127_1931761_1 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000000000004759 222.0
TLS3_k127_1931761_2 WD40-like Beta Propeller Repeat - - - 0.0002558 53.0
TLS3_k127_1953862_0 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 303.0
TLS3_k127_1953862_1 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005867 253.0
TLS3_k127_1953862_2 - - - - 0.00001689 56.0
TLS3_k127_1985063_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0 1744.0
TLS3_k127_1985063_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000001355 232.0
TLS3_k127_1985063_2 DNA-templated transcription, initiation - - - 0.0000000000000000000000000000000000000000000000000002781 200.0
TLS3_k127_1985063_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000001896 171.0
TLS3_k127_1985063_4 Haem-binding domain - - - 0.000000000000000000000000000000002324 135.0
TLS3_k127_1985063_5 protocatechuate 3,4-dioxygenase activity K00449 - 1.13.11.3 0.0000000000000000000000000000001047 132.0
TLS3_k127_1985063_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000003764 127.0
TLS3_k127_1985063_7 Periplasmic or secreted lipoprotein - - - 0.00000000007459 71.0
TLS3_k127_1989189_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 532.0
TLS3_k127_1989189_1 lactoylglutathione lyase activity - - - 0.00000000000000000000000003067 111.0
TLS3_k127_2014451_0 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 398.0
TLS3_k127_2014451_1 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000001379 119.0
TLS3_k127_2014451_2 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000001256 99.0
TLS3_k127_2014451_3 cheY-homologous receiver domain - - - 0.0000000000000000000002154 102.0
TLS3_k127_2014464_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 579.0
TLS3_k127_2014464_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 552.0
TLS3_k127_2014464_10 Gram-negative-bacterium-type cell wall biogenesis - - - 0.0000000003988 69.0
TLS3_k127_2014464_2 Glutamine amidotransferase domain K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 557.0
TLS3_k127_2014464_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005242 354.0
TLS3_k127_2014464_4 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006887 252.0
TLS3_k127_2014464_5 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000006349 199.0
TLS3_k127_2014464_6 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000002905 155.0
TLS3_k127_2014464_7 chitinase K01183 - 3.2.1.14 0.0000000000000000001602 105.0
TLS3_k127_2014464_9 Pectate lyase superfamily protein - - - 0.0000000001501 76.0
TLS3_k127_2045686_0 Flotillin K07192 - - 0.000000000000000000000000000000000000000000000000000000000000000002305 232.0
TLS3_k127_2045686_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000004121 82.0
TLS3_k127_2045686_2 Putative zinc-finger - - - 0.00001416 56.0
TLS3_k127_2045686_3 cellular response to DNA damage stimulus - GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - 0.000156 51.0
TLS3_k127_2045686_4 PBS lyase HEAT-like repeat - - - 0.0002409 53.0
TLS3_k127_2045686_5 Outer membrane lipoprotein - - - 0.0005554 52.0
TLS3_k127_2046112_0 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 565.0
TLS3_k127_2046112_1 Zinc-binding alcohol dehydrogenase family protein K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 414.0
TLS3_k127_2046112_2 HlyD family secretion protein K02005 - - 0.00000000000000000000000000000000000000000000004848 174.0
TLS3_k127_2046112_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000002242 131.0
TLS3_k127_2046112_4 - - - - 0.0000000000000000000000000001825 120.0
TLS3_k127_2046112_5 - - - - 0.00000000000000000146 89.0
TLS3_k127_2046112_6 - - - - 0.000000000002146 70.0
TLS3_k127_2056674_1 DNA mismatch repair protein K08739 GO:0000003,GO:0000228,GO:0000280,GO:0000793,GO:0000794,GO:0000795,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005712,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0022414,GO:0031974,GO:0031981,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0035825,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0046483,GO:0048285,GO:0050896,GO:0051321,GO:0051716,GO:0061982,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0099086,GO:0140013,GO:1901360,GO:1901363,GO:1903046,GO:1990391 - 0.0002441 54.0
TLS3_k127_2061362_0 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 371.0
TLS3_k127_2061362_1 PFAM ABC transporter related K01990,K16907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006696 324.0
TLS3_k127_2061362_2 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000252 278.0
TLS3_k127_2061362_3 divalent heavy-metal cations transporter K07238 - - 0.00000000000000000000000000000000000000000000000000000000000001277 227.0
TLS3_k127_2061362_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000004545 216.0
TLS3_k127_2061362_5 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins K03790 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.000000000000000000000008645 104.0
TLS3_k127_2061362_6 - - - - 0.00000000493 62.0
TLS3_k127_2061362_7 - - - - 0.00000004437 63.0
TLS3_k127_2061362_8 Transport permease protein K01992 - - 0.0001731 53.0
TLS3_k127_2116271_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.123e-301 945.0
TLS3_k127_2116271_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 1.136e-203 655.0
TLS3_k127_2116271_10 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.00000000000000000123 94.0
TLS3_k127_2116271_11 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000007082 74.0
TLS3_k127_2116271_12 - - - - 0.000000000001709 77.0
TLS3_k127_2116271_13 Domain of unknown function (DUF4956) - - - 0.000000000002207 78.0
TLS3_k127_2116271_14 Cold shock - - - 0.0000001626 53.0
TLS3_k127_2116271_15 Putative zinc-finger - - - 0.0008308 50.0
TLS3_k127_2116271_2 PFAM magnesium chelatase K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 538.0
TLS3_k127_2116271_3 Lytic transglycosylase catalytic K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000001351 248.0
TLS3_k127_2116271_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000008322 222.0
TLS3_k127_2116271_5 - - - - 0.000000000000000000000000000000000000000000000000000383 197.0
TLS3_k127_2116271_6 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000002316 176.0
TLS3_k127_2116271_7 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K07313 - 3.1.3.16 0.0000000000000000000000000000000000000000005191 165.0
TLS3_k127_2116271_8 Peptidase family M23 - - - 0.000000000000000000000000000000000002043 150.0
TLS3_k127_2116271_9 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000006502 111.0
TLS3_k127_2164681_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.587e-210 664.0
TLS3_k127_2164681_1 UPF0210 protein K09157 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000967 561.0
TLS3_k127_2164681_10 Belongs to the UPF0237 family K07166 - - 0.00000000000000000138 91.0
TLS3_k127_2164681_11 Helix-turn-helix domain K15539 - - 0.000000000000989 76.0
TLS3_k127_2164681_12 Belongs to the 'phage' integrase family K04763 - - 0.0000000004272 63.0
TLS3_k127_2164681_13 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.0000000006418 70.0
TLS3_k127_2164681_14 Phage integrase family - - - 0.0001104 48.0
TLS3_k127_2164681_2 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 460.0
TLS3_k127_2164681_3 protease with the C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 337.0
TLS3_k127_2164681_4 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004119 291.0
TLS3_k127_2164681_5 lipid kinase, YegS Rv2252 BmrU family - - - 0.00000000000000000000000000000000000000000000007422 180.0
TLS3_k127_2164681_6 BMC K04027 - - 0.0000000000000000000000000000000000000741 147.0
TLS3_k127_2164681_7 Carbon dioxide concentrating mechanism carboxysome shell protein - - - 0.000000000000000000000000000001722 123.0
TLS3_k127_2164681_8 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.0000000000000000000000000002355 117.0
TLS3_k127_2164681_9 TraG-like protein, N-terminal region - - - 0.000000000000000000000001255 115.0
TLS3_k127_2186095_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1016.0
TLS3_k127_2186095_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 5.509e-251 784.0
TLS3_k127_2186095_2 PFAM amino acid permease-associated region K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 452.0
TLS3_k127_2186095_3 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 428.0
TLS3_k127_2186095_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000318 265.0
TLS3_k127_2186095_5 DoxX - - - 0.000000000000000000000000000000000000000000000000000008133 195.0
TLS3_k127_2186095_6 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000002679 194.0
TLS3_k127_2186095_7 Alpha/beta hydrolase family - - - 0.0000000000000000000000000001738 119.0
TLS3_k127_219803_0 Phage tail sheath C-terminal domain K06907 - - 4.611e-258 808.0
TLS3_k127_219803_1 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 479.0
TLS3_k127_219803_10 - - - - 0.0000000000001328 77.0
TLS3_k127_219803_11 hydrolase activity, acting on ester bonds - - - 0.00000000003825 64.0
TLS3_k127_219803_2 Phage tail sheath protein subtilisin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 473.0
TLS3_k127_219803_3 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006797 271.0
TLS3_k127_219803_4 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000422 225.0
TLS3_k127_219803_5 M1 (1,4-beta-N-acetylmuramidase) K07273 - - 0.0000000000000000000000000000000000000000000000000000000003558 209.0
TLS3_k127_219803_6 - - - - 0.00000000000000000000000000000000000000000000000000000003778 207.0
TLS3_k127_219803_7 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000008873 194.0
TLS3_k127_219803_8 Protein of unknown function (DUF4255) - - - 0.000000000000000000000000000000000000000000000000002297 188.0
TLS3_k127_219803_9 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000002166 167.0
TLS3_k127_2243946_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 477.0
TLS3_k127_2243946_1 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000112 263.0
TLS3_k127_2243946_2 Belongs to the phosphoglycerate mutase family K15634 - 5.4.2.12 0.00000000000000000000000000000005161 132.0
TLS3_k127_2243946_3 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000004739 120.0
TLS3_k127_2257590_0 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 536.0
TLS3_k127_2257590_1 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000004549 213.0
TLS3_k127_2257590_2 actin binding - - - 0.00000000000000000000000000000000000000000007433 177.0
TLS3_k127_2257590_3 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000071 94.0
TLS3_k127_2260890_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 6.75e-228 720.0
TLS3_k127_2260890_1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity K03429 - 2.4.1.315 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 502.0
TLS3_k127_2260890_10 Outer membrane protein (OmpH-like) K06142 - - 0.00000000002368 72.0
TLS3_k127_2260890_11 serine-type endopeptidase activity K04771,K07126 - 3.4.21.107 0.0001822 52.0
TLS3_k127_2260890_2 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 474.0
TLS3_k127_2260890_3 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 325.0
TLS3_k127_2260890_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000001337 202.0
TLS3_k127_2260890_5 Cupin domain - - - 0.0000000000000000000000000000000000000000000000001276 179.0
TLS3_k127_2260890_6 DinB family - - - 0.00000000000000000000000000000000000000000000001476 176.0
TLS3_k127_2260890_7 methyltransferase K18846 - 2.1.1.180 0.0000000000000000000000000000000000000006073 156.0
TLS3_k127_2260890_8 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000000005711 143.0
TLS3_k127_2283418_0 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 389.0
TLS3_k127_2283418_1 PFAM FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 332.0
TLS3_k127_2283418_2 ADP-ribosylglycohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004451 242.0
TLS3_k127_2283418_3 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000001142 231.0
TLS3_k127_2283418_4 NIPSNAP - - - 0.0000000000000000000000002073 111.0
TLS3_k127_2283418_5 HxlR-like helix-turn-helix - - - 0.0000000000000000000000015 106.0
TLS3_k127_2283418_6 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.00000000000000000000001723 103.0
TLS3_k127_2283418_7 AAA domain - - - 0.0000000000000000000001355 104.0
TLS3_k127_2283418_8 RyR domain - - - 0.000008716 59.0
TLS3_k127_2283418_9 Family of unknown function (DUF5335) - - - 0.000355 46.0
TLS3_k127_2327734_0 Protein of unknown function, DUF255 K06888 - - 1.007e-236 750.0
TLS3_k127_2327734_1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 1.68e-198 632.0
TLS3_k127_2327734_10 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 411.0
TLS3_k127_2327734_11 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 388.0
TLS3_k127_2327734_12 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 389.0
TLS3_k127_2327734_13 'ABC-type dipeptide oligopeptide nickel transport K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 355.0
TLS3_k127_2327734_14 transporter, permease K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 304.0
TLS3_k127_2327734_15 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002759 274.0
TLS3_k127_2327734_16 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000015 260.0
TLS3_k127_2327734_17 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000156 222.0
TLS3_k127_2327734_18 Methyltransferase domain K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000001183 210.0
TLS3_k127_2327734_19 Stress-induced protein - - - 0.00000000000000000000000000000000000000000000000000000000118 211.0
TLS3_k127_2327734_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 575.0
TLS3_k127_2327734_20 deoxyhypusine monooxygenase activity K00627,K02160,K07402 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000003385 211.0
TLS3_k127_2327734_21 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000003508 203.0
TLS3_k127_2327734_22 response regulator receiver K02483,K07658 - - 0.000000000000000000000000000000000000000000000000000002022 199.0
TLS3_k127_2327734_23 4Fe-4S binding domain K00395,K02572,K03616 - 1.8.99.2 0.00000000000000000000000000000000000000000000000001518 181.0
TLS3_k127_2327734_25 HD domain - - - 0.0000000000000000000000000000000000000000000002356 183.0
TLS3_k127_2327734_26 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000001276 177.0
TLS3_k127_2327734_27 PFAM penicillin-binding protein transpeptidase K05364 - - 0.000000000000000000000000000000000000000001003 177.0
TLS3_k127_2327734_28 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000004477 167.0
TLS3_k127_2327734_29 spore germination - - - 0.000000000000000000000000000000000000006971 157.0
TLS3_k127_2327734_3 metallocarboxypeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 554.0
TLS3_k127_2327734_30 Protein of unknown function (DUF420) K08976 - - 0.0000000000000000000000000000000000003296 145.0
TLS3_k127_2327734_31 Belongs to the SEDS family K03588 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.0000000000000000000000000000000007097 149.0
TLS3_k127_2327734_32 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000002824 134.0
TLS3_k127_2327734_34 - - - - 0.000000000000007452 75.0
TLS3_k127_2327734_35 sigma factor antagonist activity K04757 - 2.7.11.1 0.000000000002168 81.0
TLS3_k127_2327734_36 ABC transporter K01990,K21397 - - 0.0000000003075 70.0
TLS3_k127_2327734_38 antisigma factor binding - - - 0.0000003604 57.0
TLS3_k127_2327734_39 Protein of unknown function (DUF2662) - - - 0.000004811 57.0
TLS3_k127_2327734_4 ABC transporter K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 482.0
TLS3_k127_2327734_40 DNA-directed 5'-3' RNA polymerase activity K03060 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.00003837 49.0
TLS3_k127_2327734_5 ATPases associated with a variety of cellular activities K10823,K10824 - 3.6.3.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 449.0
TLS3_k127_2327734_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 429.0
TLS3_k127_2327734_7 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 437.0
TLS3_k127_2327734_8 Belongs to the ABC transporter superfamily K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 422.0
TLS3_k127_2327734_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008662 410.0
TLS3_k127_2336231_0 amino acid transport K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004553 521.0
TLS3_k127_2336231_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 424.0
TLS3_k127_2336231_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K04105,K04110 - 6.2.1.25,6.2.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 396.0
TLS3_k127_2336231_3 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 383.0
TLS3_k127_2336231_4 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000002173 234.0
TLS3_k127_2336231_5 membrane - - - 0.0002914 53.0
TLS3_k127_2377235_0 Sulfatase K01130 - 3.1.6.1 0.0 1255.0
TLS3_k127_2377235_1 regulation of DNA-templated transcription, elongation - - - 5.786e-242 771.0
TLS3_k127_2377235_10 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000009467 234.0
TLS3_k127_2377235_11 Protein tyrosine kinase K08884 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000006958 256.0
TLS3_k127_2377235_12 Protein of unknown function (DUF4239) - - - 0.0000000000000000000000000000000000000000000000000000001106 204.0
TLS3_k127_2377235_13 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000001964 201.0
TLS3_k127_2377235_14 Single Cache domain 2 K02480 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000001594 204.0
TLS3_k127_2377235_15 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000004084 171.0
TLS3_k127_2377235_16 long-chain fatty acid transport protein - - - 0.000000000000000000000000000000000000000000001145 175.0
TLS3_k127_2377235_17 - - - - 0.00000000000000000000000000000000000004577 149.0
TLS3_k127_2377235_18 - - - - 0.00000000000000000000000000000000000005098 151.0
TLS3_k127_2377235_19 Protein of unknown function (DUF2490) - - - 0.0000000000000000000000000000002149 133.0
TLS3_k127_2377235_2 TonB-dependent receptor - - - 8.492e-202 668.0
TLS3_k127_2377235_20 BON domain - - - 0.00000000000000000000000000002114 133.0
TLS3_k127_2377235_21 cheY-homologous receiver domain - - - 0.00000000000000000000000000003423 125.0
TLS3_k127_2377235_22 Citrate transporter - - - 0.0000000000000000000004966 96.0
TLS3_k127_2377235_23 Protein of unknown function (DUF502) - - - 0.00000000000000000004518 98.0
TLS3_k127_2377235_25 PFAM RNA-directed DNA polymerase (Reverse transcriptase) K00986 - 2.7.7.49 0.000000000000001269 79.0
TLS3_k127_2377235_26 Antibiotic biosynthesis monooxygenase - - - 0.000000000006382 71.0
TLS3_k127_2377235_27 Protein of unknown function (DUF1254) - - - 0.000000002192 58.0
TLS3_k127_2377235_29 OmpA family K03286 - - 0.00002032 48.0
TLS3_k127_2377235_3 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 511.0
TLS3_k127_2377235_30 chlorophyll binding - - - 0.00002593 48.0
TLS3_k127_2377235_4 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 459.0
TLS3_k127_2377235_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004355 429.0
TLS3_k127_2377235_6 transcription factor binding K15836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 447.0
TLS3_k127_2377235_7 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 359.0
TLS3_k127_2377235_8 Mechanosensitive ion channel K16052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 338.0
TLS3_k127_2377235_9 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003336 265.0
TLS3_k127_2396525_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 434.0
TLS3_k127_2396525_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003925 291.0
TLS3_k127_2396525_2 Cell shape determining protein, MreB Mrl family K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007397 270.0
TLS3_k127_2396525_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000000000000000000000000000000000000000000000000000000001819 218.0
TLS3_k127_2396525_4 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000009437 206.0
TLS3_k127_2396525_5 domain protein - - - 0.000000000000000001234 100.0
TLS3_k127_2396525_6 Carboxypeptidase regulatory-like domain - - - 0.00003718 57.0
TLS3_k127_2396525_7 YbbR-like protein - - - 0.0005814 51.0
TLS3_k127_2408549_0 Polysaccharide biosynthesis protein K17947 - 5.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 423.0
TLS3_k127_2408549_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005831 289.0
TLS3_k127_2408549_2 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002582 275.0
TLS3_k127_2408549_3 maltose O-acetyltransferase activity - - - 0.000000000000000000000000000000000000000000000000003309 190.0
TLS3_k127_2408549_4 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000001304 157.0
TLS3_k127_2408549_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000473 129.0
TLS3_k127_244154_0 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 465.0
TLS3_k127_244154_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006057 463.0
TLS3_k127_244154_10 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000001994 225.0
TLS3_k127_244154_11 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000002869 207.0
TLS3_k127_244154_12 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000002628 177.0
TLS3_k127_244154_13 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000001531 168.0
TLS3_k127_244154_14 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000106 146.0
TLS3_k127_244154_15 HD domain - - - 0.00000000000000000000000000000000001676 143.0
TLS3_k127_244154_16 Histidine kinase - - - 0.000000000000000000000000000000001835 141.0
TLS3_k127_244154_17 Probable zinc-ribbon domain - - - 0.000000000000000000001618 98.0
TLS3_k127_244154_18 PFAM D12 class N6 adenine-specific DNA methyltransferase K07318 - 2.1.1.72 0.000000009395 66.0
TLS3_k127_244154_19 Tetratricopeptide repeat - - - 0.000000717 61.0
TLS3_k127_244154_2 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 424.0
TLS3_k127_244154_20 DnaJ (Hsp40) homolog, subfamily C , member 25 K19371 - - 0.00002562 57.0
TLS3_k127_244154_21 calcium- and calmodulin-responsive adenylate cyclase activity K01406 - 3.4.24.40 0.00009113 54.0
TLS3_k127_244154_3 PFAM sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 389.0
TLS3_k127_244154_4 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 385.0
TLS3_k127_244154_5 peptidase dimerisation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 384.0
TLS3_k127_244154_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 308.0
TLS3_k127_244154_7 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 302.0
TLS3_k127_244154_8 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002298 282.0
TLS3_k127_244154_9 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003403 283.0
TLS3_k127_2533884_0 Carboxypeptidase regulatory-like domain - - - 1.185e-243 786.0
TLS3_k127_2533884_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 455.0
TLS3_k127_2533884_2 amino acid K03294,K13868 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 359.0
TLS3_k127_2533884_3 PhoQ Sensor K07640 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 353.0
TLS3_k127_2533884_4 Transcriptional regulatory protein, C terminal K07662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 305.0
TLS3_k127_2533884_5 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000001445 224.0
TLS3_k127_2533884_6 phosphatidate phosphatase activity K19302 - 3.6.1.27 0.00000000000000000000000000000000001811 144.0
TLS3_k127_2543146_0 Belongs to the HpcH HpaI aldolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 554.0
TLS3_k127_2543146_1 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 313.0
TLS3_k127_2543146_2 UPF0314 protein - - - 0.00000000000000000000000000000000000000002856 159.0
TLS3_k127_2558261_0 Peptidase M14, carboxypeptidase A - - - 0.0 1400.0
TLS3_k127_2558261_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1073.0
TLS3_k127_2558261_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 642.0
TLS3_k127_2558261_3 nitrite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 409.0
TLS3_k127_2558261_4 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 403.0
TLS3_k127_2558261_5 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000078 360.0
TLS3_k127_2558261_6 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 355.0
TLS3_k127_2558261_7 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 314.0
TLS3_k127_2558261_8 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004565 275.0
TLS3_k127_2558261_9 GAF domain K08968 - 1.8.4.14 0.000000000000000000000000000000000000000000000000000000006845 203.0
TLS3_k127_259247_0 efflux transmembrane transporter activity - - - 3.266e-240 766.0
TLS3_k127_259247_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 623.0
TLS3_k127_259247_10 Hemerythrin HHE cation binding domain K07216 - - 0.000000007162 63.0
TLS3_k127_259247_11 - - - - 0.0000001387 57.0
TLS3_k127_259247_12 xylan catabolic process K03932 - - 0.00001687 55.0
TLS3_k127_259247_13 - - - - 0.00003329 51.0
TLS3_k127_259247_14 Involved in the tonB-independent uptake of proteins K03641 - - 0.0001727 48.0
TLS3_k127_259247_15 Aspartate-ammonia ligase K01914 GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 0.0005016 42.0
TLS3_k127_259247_2 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 384.0
TLS3_k127_259247_3 Succinylglutamate desuccinylase / Aspartoacylase family K05526 - 3.5.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001747 279.0
TLS3_k127_259247_4 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171,K18841 GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0022607,GO:0030308,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0042802,GO:0042803,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044877,GO:0045926,GO:0046483,GO:0046700,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051259,GO:0051291,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000003417 107.0
TLS3_k127_259247_5 Belongs to the 'phage' integrase family - - - 0.00000000000000000001271 97.0
TLS3_k127_259247_6 PilT protein domain protein - - - 0.00000000000000000001603 94.0
TLS3_k127_259247_7 Putative phosphatase (DUF442) - - - 0.00000000000000008441 89.0
TLS3_k127_259247_8 SpoVT / AbrB like domain K07172 - - 0.000000000005566 67.0
TLS3_k127_259247_9 beta-propeller repeat - - - 0.0000000001906 64.0
TLS3_k127_2605374_0 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000002265 178.0
TLS3_k127_2605374_1 membrane protein (DUF2157) - - - 0.00000000000000000000000000000000000000000000001397 188.0
TLS3_k127_2605374_2 Peptidase, M61 - - - 0.00000000000000000000000000000000000000463 166.0
TLS3_k127_2605374_3 GDYXXLXY protein - - - 0.00000000000000000000000000007355 124.0
TLS3_k127_2605374_4 Nuclear protein SET K07117 - - 0.000000000000000000005996 99.0
TLS3_k127_2605374_5 Glyco_18 K01183 - 3.2.1.14 0.0000000000003174 81.0
TLS3_k127_2605374_6 - - - - 0.0000000000562 70.0
TLS3_k127_2639053_0 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 454.0
TLS3_k127_2639053_1 FAD binding domain K21401 - 1.3.99.38 0.0000000000000000000000000000000000000004128 164.0
TLS3_k127_2639053_2 Methyltransferase domain - - - 0.000000000000000000000000000000000007774 148.0
TLS3_k127_2648427_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000982 535.0
TLS3_k127_2648427_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005868 250.0
TLS3_k127_2648427_2 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000000000006321 187.0
TLS3_k127_2648427_4 - - - - 0.000000001763 64.0
TLS3_k127_2662512_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1341.0
TLS3_k127_2662512_1 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000416 574.0
TLS3_k127_2662512_10 abc-type fe3 -hydroxamate transport system, periplasmic component - - - 0.000000000000000000000000000000000000004873 149.0
TLS3_k127_2662512_11 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000003544 153.0
TLS3_k127_2662512_12 Transthyretin K07127 - 3.5.2.17 0.00000000000000000000000000000000137 133.0
TLS3_k127_2662512_3 Belongs to the allantoicase family K01477 - 3.5.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 459.0
TLS3_k127_2662512_4 Aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 365.0
TLS3_k127_2662512_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 337.0
TLS3_k127_2662512_6 Cell shape determining protein MreB Mrl K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003585 278.0
TLS3_k127_2662512_7 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004116 256.0
TLS3_k127_2662512_8 PFAM Isochorismatase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000008984 203.0
TLS3_k127_2662512_9 allantoin biosynthetic process K01477,K16840 - 3.5.3.4,4.1.1.97 0.0000000000000000000000000000000000000000007323 162.0
TLS3_k127_2673234_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 579.0
TLS3_k127_2673234_1 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002229 281.0
TLS3_k127_2673234_2 Protein of unknown function (DUF1003) - - - 0.00000000000000000000000000000000000000000000000000000000000003465 228.0
TLS3_k127_2673234_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000004048 208.0
TLS3_k127_2673234_4 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K01091,K01838 - 3.1.3.18,5.4.2.6 0.0000000000000000000000000000000000246 143.0
TLS3_k127_2673234_5 histone H2A K63-linked ubiquitination - - - 0.000000000002649 74.0
TLS3_k127_2673234_6 Tetratricopeptide repeat - - - 0.000000004284 69.0
TLS3_k127_2675771_0 Cleaves the N-terminal amino acid of tripeptides K01258 - 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 413.0
TLS3_k127_2675771_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 380.0
TLS3_k127_2675771_10 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.0000000000000000000000000001964 119.0
TLS3_k127_2675771_11 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000000000001165 110.0
TLS3_k127_2675771_12 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000006083 107.0
TLS3_k127_2675771_13 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000001301 96.0
TLS3_k127_2675771_14 Tetratricopeptide repeat - - - 0.000000000000003898 89.0
TLS3_k127_2675771_15 - - - - 0.000008203 51.0
TLS3_k127_2675771_2 Subtilase family K14645 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 351.0
TLS3_k127_2675771_3 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 291.0
TLS3_k127_2675771_4 KH domain K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000803 275.0
TLS3_k127_2675771_5 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000002857 172.0
TLS3_k127_2675771_6 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 0.00000000000000000000000000000000000000000008012 169.0
TLS3_k127_2675771_7 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000000000003164 164.0
TLS3_k127_2675771_8 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000000000000000000000000000004646 142.0
TLS3_k127_2675771_9 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000000000000000000000000000914 136.0
TLS3_k127_2751271_0 PFAM type II secretion system protein E K02283,K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 559.0
TLS3_k127_2751271_1 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002501 292.0
TLS3_k127_2751271_10 ATPases associated with a variety of cellular activities - - - 0.00000000000000006197 85.0
TLS3_k127_2751271_11 TadE-like protein - - - 0.00000000001604 70.0
TLS3_k127_2751271_12 TadE-like protein - - - 0.0000000313 62.0
TLS3_k127_2751271_13 Flp Fap pilin component K02651 - - 0.0006968 44.0
TLS3_k127_2751271_2 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003104 290.0
TLS3_k127_2751271_3 Type II secretion system K12510 - - 0.00000000000000000000000000000000000000000000000000000000009886 217.0
TLS3_k127_2751271_4 Secretion system protein K12511 - - 0.000000000000000000000000000000000000000000000000000000009238 210.0
TLS3_k127_2751271_5 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000000000000000000000000000000000000003339 198.0
TLS3_k127_2751271_6 NUBPL iron-transfer P-loop NTPase K02282 - - 0.00000000000000000000000000000000000000000000000000007227 202.0
TLS3_k127_2751271_7 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000003334 109.0
TLS3_k127_2751271_8 repeat-containing protein - - - 0.000000000000000006714 95.0
TLS3_k127_2751271_9 Type IV leader peptidase family K02278 - 3.4.23.43 0.000000000000000007315 93.0
TLS3_k127_2761634_0 glycoside hydrolase family 38 K01191 - 3.2.1.24 0.0 1420.0
TLS3_k127_2761634_1 3-isopropylmalate dehydratase activity K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 1.755e-226 708.0
TLS3_k127_2761634_10 Aconitase C-terminal domain K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001057 279.0
TLS3_k127_2761634_11 Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003822 271.0
TLS3_k127_2761634_12 HPr kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001373 276.0
TLS3_k127_2761634_13 PRMT5 arginine-N-methyltransferase K11434 - 2.1.1.319 0.00000000000000000000000000000000000000000000000000000000008805 210.0
TLS3_k127_2761634_14 Peptidase of plants and bacteria - - - 0.0000000000000000000000000000000000000000000000000001406 192.0
TLS3_k127_2761634_15 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000000000000000003315 96.0
TLS3_k127_2761634_2 ABC transporter K10441 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 582.0
TLS3_k127_2761634_3 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 489.0
TLS3_k127_2761634_4 TIGRFAM iron-sulfur cluster binding protein K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 462.0
TLS3_k127_2761634_5 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 403.0
TLS3_k127_2761634_6 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006338 400.0
TLS3_k127_2761634_7 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 364.0
TLS3_k127_2761634_8 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01707 - 4.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 322.0
TLS3_k127_2761634_9 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 306.0
TLS3_k127_27746_0 Prolyl oligopeptidase family - - - 4.644e-261 823.0
TLS3_k127_27746_1 Dienelactone hydrolase family - - - 3.078e-239 760.0
TLS3_k127_27746_10 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 406.0
TLS3_k127_27746_11 beta' subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005267 387.0
TLS3_k127_27746_12 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 400.0
TLS3_k127_27746_13 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000927 350.0
TLS3_k127_27746_14 RNA polymerase sigma-54 factor K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007653 350.0
TLS3_k127_27746_15 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006087 337.0
TLS3_k127_27746_16 lipopolysaccharide-transporting ATPase activity K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 314.0
TLS3_k127_27746_17 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001337 278.0
TLS3_k127_27746_18 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000005515 261.0
TLS3_k127_27746_19 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000005409 229.0
TLS3_k127_27746_2 Pfam:KaiC K08482 - - 2.611e-224 709.0
TLS3_k127_27746_20 PFAM OsmC family protein - - - 0.0000000000000000000000000000000000000000000000000000000000001795 217.0
TLS3_k127_27746_21 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000008137 228.0
TLS3_k127_27746_22 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000008758 192.0
TLS3_k127_27746_23 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000003249 181.0
TLS3_k127_27746_24 Putative zinc-finger - - - 0.0000000000000000000000000000000000000000000001337 179.0
TLS3_k127_27746_25 Lysin motif - - - 0.000000000000000000000000000000000000000001919 160.0
TLS3_k127_27746_26 PFAM KaiB domain K08481 - - 0.0000000000000000000000000000000000000001579 153.0
TLS3_k127_27746_27 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000000000001028 148.0
TLS3_k127_27746_28 PTS system fructose IIA component K02793,K02794,K02821 - 2.7.1.191,2.7.1.194 0.000000000000000000000000000000005962 134.0
TLS3_k127_27746_29 lipopolysaccharide transport K09774 - - 0.00000000000000000000000000000001187 147.0
TLS3_k127_27746_3 Beta propeller domain - - - 5.522e-208 664.0
TLS3_k127_27746_30 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000000000000000000000000000003285 130.0
TLS3_k127_27746_31 KaiB K08481 - - 0.00000000000000000000000000001002 123.0
TLS3_k127_27746_32 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.0000000000000008089 83.0
TLS3_k127_27746_33 PhoQ Sensor - - - 0.000000001023 64.0
TLS3_k127_27746_34 CAAX protease self-immunity K07052 - - 0.00000002436 63.0
TLS3_k127_27746_35 Glycosyl transferase family 2 - - - 0.000127 51.0
TLS3_k127_27746_36 Acetyltransferase (GNAT) domain - - - 0.0005763 44.0
TLS3_k127_27746_4 Prolyl oligopeptidase family - - - 1.465e-198 638.0
TLS3_k127_27746_5 Cytochrome c - - - 9.872e-196 620.0
TLS3_k127_27746_6 IgA Peptidase M64 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003999 598.0
TLS3_k127_27746_7 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 521.0
TLS3_k127_27746_8 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 500.0
TLS3_k127_27746_9 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008783 470.0
TLS3_k127_279107_0 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 2.403e-219 692.0
TLS3_k127_279107_1 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 569.0
TLS3_k127_279107_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 487.0
TLS3_k127_279107_3 PFAM Alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007618 329.0
TLS3_k127_279107_4 Trypsin K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009621 306.0
TLS3_k127_279107_5 Metallo-beta-lactamase superfamily K02238 - - 0.00000000000000000000000000000000000000000000008472 184.0
TLS3_k127_279107_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000002582 71.0
TLS3_k127_2801023_0 Tricorn protease C1 domain K08676 - - 0.0 1325.0
TLS3_k127_2801023_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008801 244.0
TLS3_k127_2801023_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000001573 177.0
TLS3_k127_2801023_3 acetyltransferase - - - 0.000000000000000000000000000000000000000005436 160.0
TLS3_k127_2801023_4 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000001255 123.0
TLS3_k127_2801023_5 - - - - 0.000000000000000000000001817 109.0
TLS3_k127_2801023_6 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000000000001587 97.0
TLS3_k127_2801023_7 Gram-negative bacterial TonB protein C-terminal - - - 0.000000003464 64.0
TLS3_k127_2801023_8 Protein of unknown function (DUF445) - - - 0.0004721 51.0
TLS3_k127_2824148_0 Cytochrome c - - - 0.0 1164.0
TLS3_k127_2824148_1 Domain of unknown function (DUF4331) - - - 1.109e-272 845.0
TLS3_k127_2824148_2 B12 binding domain - - - 2.758e-227 716.0
TLS3_k127_2824148_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 398.0
TLS3_k127_2845941_0 PEP-utilising enzyme, mobile domain - - - 0.0 1065.0
TLS3_k127_2845941_1 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 523.0
TLS3_k127_2845941_2 COGs COG2823 periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000000000002494 176.0
TLS3_k127_2845941_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000001811 138.0
TLS3_k127_2860695_0 serine-type exopeptidase activity K01322 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.21.26 5.511e-297 928.0
TLS3_k127_2860695_1 MviN-like protein K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 611.0
TLS3_k127_2860695_10 ABC-type polar amino acid transport system, ATPase component K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000009199 237.0
TLS3_k127_2860695_11 PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000001359 181.0
TLS3_k127_2860695_12 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000000000000000000000005904 147.0
TLS3_k127_2860695_13 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000007794 115.0
TLS3_k127_2860695_14 PIN domain - - - 0.000000000000000000000001419 109.0
TLS3_k127_2860695_15 Pilus assembly protein PilX K02673 - - 0.00000000000000001295 96.0
TLS3_k127_2860695_16 gag-polyprotein putative aspartyl protease - - - 0.000000000003703 79.0
TLS3_k127_2860695_17 PEP-CTERM motif - - - 0.000000005425 66.0
TLS3_k127_2860695_18 Pfam:N_methyl_2 - - - 0.00004094 54.0
TLS3_k127_2860695_2 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 608.0
TLS3_k127_2860695_3 Glycosyl hydrolase family 47 K01230 - 3.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 544.0
TLS3_k127_2860695_4 proline dipeptidase activity K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 516.0
TLS3_k127_2860695_5 Aminotransferase class-III K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 509.0
TLS3_k127_2860695_6 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 488.0
TLS3_k127_2860695_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 447.0
TLS3_k127_2860695_8 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 387.0
TLS3_k127_2860695_9 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 344.0
TLS3_k127_2923150_0 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 399.0
TLS3_k127_2923150_1 Beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000001358 241.0
TLS3_k127_2923150_2 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000000000009884 213.0
TLS3_k127_2923150_3 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000002417 193.0
TLS3_k127_2923150_4 BMC K04027 - - 0.00000000000000000000000000000000005334 135.0
TLS3_k127_2923150_5 peptidyl-tyrosine sulfation K03217,K06872 - - 0.000000000000000000000000000000005715 141.0
TLS3_k127_2923150_6 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028,K08697 - - 0.00000000000000000000000000001532 119.0
TLS3_k127_2923150_7 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000004385 67.0
TLS3_k127_2926269_0 SMART Elongator protein 3 MiaB NifB - - - 5.624e-239 749.0
TLS3_k127_2926269_1 PFAM FAD dependent oxidoreductase - - - 1.64e-206 654.0
TLS3_k127_2926269_10 Gas vesicle protein K - - - 0.0000000000000000000000000000009957 124.0
TLS3_k127_2926269_11 Plasmid stabilization - - - 0.00000000000000000000000000003791 117.0
TLS3_k127_2926269_12 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.00000000000000000000000000218 115.0
TLS3_k127_2926269_13 Gas vesicle synthesis protein GvpL/GvpF - - - 0.000000000000000000002392 103.0
TLS3_k127_2926269_14 - - - - 0.0000000000000134 76.0
TLS3_k127_2926269_15 gas vesicle protein - - - 0.000000000003369 68.0
TLS3_k127_2926269_17 - - - - 0.000000001476 61.0
TLS3_k127_2926269_19 - - - - 0.00002283 49.0
TLS3_k127_2926269_2 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 417.0
TLS3_k127_2926269_3 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 411.0
TLS3_k127_2926269_4 Arsenical pump-driving ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 404.0
TLS3_k127_2926269_5 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005287 382.0
TLS3_k127_2926269_6 CHASE3 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009043 361.0
TLS3_k127_2926269_7 heat shock protein binding K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 331.0
TLS3_k127_2926269_8 Gas vesicle synthesis protein GvpL/GvpF - - - 0.000000000000000000000000000000002652 139.0
TLS3_k127_2926269_9 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.0000000000000000000000000000006875 123.0
TLS3_k127_295176_0 Carboxypeptidase regulatory-like domain - - - 2.819e-273 873.0
TLS3_k127_295176_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 4.31e-197 646.0
TLS3_k127_295176_10 - - - - 0.0000000000000000000000000000000000006795 147.0
TLS3_k127_295176_11 phosphorelay sensor kinase activity K07710,K10942 - 2.7.13.3 0.00000000000000000000000000000000003322 153.0
TLS3_k127_295176_13 - - - - 0.0000000000000000229 92.0
TLS3_k127_295176_14 oxidoreductase activity - - - 0.00000002821 61.0
TLS3_k127_295176_15 phosphate-selective porin O and P - - - 0.00000003717 64.0
TLS3_k127_295176_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005788 467.0
TLS3_k127_295176_3 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008346 353.0
TLS3_k127_295176_4 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005676 312.0
TLS3_k127_295176_5 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005382 282.0
TLS3_k127_295176_6 ABC-type Fe3 transport system permease component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002119 291.0
TLS3_k127_295176_7 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000009887 233.0
TLS3_k127_295176_8 DNA methylase K07316 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000009032 223.0
TLS3_k127_295176_9 Belongs to the ABC transporter superfamily K02010,K02045 - 3.6.3.25,3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000006862 219.0
TLS3_k127_3041588_0 Belongs to the glycosyl hydrolase 31 family K01811 - 3.2.1.177 0.0 1107.0
TLS3_k127_3041588_1 Protein of unknown function (DUF1003) - - - 0.0000000000000000000000000000000000000000391 158.0
TLS3_k127_3041588_2 O-methyltransferase activity - - - 0.00000000000000000000000000000000003245 145.0
TLS3_k127_3041588_3 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000002641 87.0
TLS3_k127_3041588_4 PLD-like domain K17717 - 3.1.4.4 0.0001783 55.0
TLS3_k127_3041588_5 Pkd domain containing protein - - - 0.0004078 54.0
TLS3_k127_3060931_0 Radical SAM - - - 1.33e-321 995.0
TLS3_k127_3060931_1 Tetratricopeptide repeat - - - 7.878e-215 702.0
TLS3_k127_3060931_2 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 312.0
TLS3_k127_3060931_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000007272 245.0
TLS3_k127_3060931_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000395 230.0
TLS3_k127_3060931_5 Clostripain family - - - 0.00000000000000000000000000000000000000000000007164 188.0
TLS3_k127_3060931_6 transglycosylase K01185 - 3.2.1.17 0.00000000000000000000000000000000005 146.0
TLS3_k127_3060931_7 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.00000000000001589 76.0
TLS3_k127_3117650_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 582.0
TLS3_k127_3117650_1 Aminotransferase class-III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004719 578.0
TLS3_k127_3117650_2 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 409.0
TLS3_k127_3117650_3 Fungal family of unknown function (DUF1776) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 404.0
TLS3_k127_3117650_4 Uncharacterized conserved protein (COG2071) K09166 - - 0.0000000000000000000000000000000000000000000000000000000000007908 218.0
TLS3_k127_3195286_0 nodulation K00612 - - 3.471e-255 799.0
TLS3_k127_3195286_1 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000069 605.0
TLS3_k127_3195286_10 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000361 125.0
TLS3_k127_3195286_11 PFAM SMP-30 Gluconolaconase - - - 0.000000000000277 84.0
TLS3_k127_3195286_12 peptidase activity - - - 0.000000000000835 83.0
TLS3_k127_3195286_14 - - - - 0.00000000255 61.0
TLS3_k127_3195286_15 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00000002801 60.0
TLS3_k127_3195286_16 nodulation - - - 0.0000000351 61.0
TLS3_k127_3195286_18 Flavin containing amine oxidoreductase - - - 0.000000725 55.0
TLS3_k127_3195286_19 polysaccharide export K01991,K20988 - - 0.0004293 46.0
TLS3_k127_3195286_2 alpha-L-arabinofuranosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 469.0
TLS3_k127_3195286_3 guanyl-nucleotide exchange factor activity K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 412.0
TLS3_k127_3195286_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 334.0
TLS3_k127_3195286_5 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 293.0
TLS3_k127_3195286_6 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001049 280.0
TLS3_k127_3195286_7 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001447 273.0
TLS3_k127_3195286_8 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000007537 213.0
TLS3_k127_3195286_9 - - - - 0.0000000000000000000000000000000000000000007198 181.0
TLS3_k127_3200646_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 5.017e-204 642.0
TLS3_k127_3200646_1 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008204 402.0
TLS3_k127_3200646_10 Rieske [2Fe-2S] domain K03886 - - 0.0000000000000000000000001503 112.0
TLS3_k127_3200646_12 ATP-independent chaperone mediated protein folding K06006 - - 0.000009603 54.0
TLS3_k127_3200646_13 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00006316 52.0
TLS3_k127_3200646_14 - - - - 0.00009942 49.0
TLS3_k127_3200646_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 388.0
TLS3_k127_3200646_3 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 299.0
TLS3_k127_3200646_4 Belongs to the arginase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 290.0
TLS3_k127_3200646_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002504 298.0
TLS3_k127_3200646_6 Transposase IS116/IS110/IS902 family - - - 0.000000000000000000000000000000000000000000000000000000000006661 220.0
TLS3_k127_3200646_7 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.00000000000000000000000000000000000000000004263 177.0
TLS3_k127_3200646_8 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000003431 133.0
TLS3_k127_3200646_9 Sigma-70, region 4 - - - 0.0000000000000000000000000001193 123.0
TLS3_k127_32327_0 COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component K09014 - - 3.192e-256 795.0
TLS3_k127_32327_1 Amidohydrolase family K01464 - 3.5.2.2 5.289e-198 626.0
TLS3_k127_32327_10 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 432.0
TLS3_k127_32327_11 endonuclease exonuclease phosphatase K07004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 448.0
TLS3_k127_32327_12 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007563 416.0
TLS3_k127_32327_13 Large family of predicted nucleotide-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 408.0
TLS3_k127_32327_14 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 381.0
TLS3_k127_32327_15 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008405 353.0
TLS3_k127_32327_16 DEAD DEAH box helicase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008356 350.0
TLS3_k127_32327_17 PFAM Basic membrane lipoprotein K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 337.0
TLS3_k127_32327_18 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 329.0
TLS3_k127_32327_19 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 312.0
TLS3_k127_32327_2 permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 583.0
TLS3_k127_32327_20 Exodeoxyribonuclease iii K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 306.0
TLS3_k127_32327_21 neuron death in response to oxidative stress K01173,K07004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 329.0
TLS3_k127_32327_22 peptidase dimerisation domain protein K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002711 291.0
TLS3_k127_32327_23 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008977 286.0
TLS3_k127_32327_24 Phosphoribulokinase / Uridine kinase family K00855,K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19,2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000137 248.0
TLS3_k127_32327_25 iron-sulfur transferase activity K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.000000000000000000000000000000000000000000000000000006958 192.0
TLS3_k127_32327_26 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.00000000000000000000000000000000000000000000000004273 186.0
TLS3_k127_32327_27 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000001476 176.0
TLS3_k127_32327_28 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.000000000000000000000000000000000000000000004663 168.0
TLS3_k127_32327_29 Evidence 5 No homology to any previously reported sequences K07004,K13276 - - 0.0000000000000000000000000000000000000000001426 185.0
TLS3_k127_32327_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000544 575.0
TLS3_k127_32327_31 cell adhesion involved in biofilm formation - - - 0.00000000000000000000000000000000000001525 168.0
TLS3_k127_32327_32 RNA recognition motif - - - 0.000000000000000000000000000000000505 134.0
TLS3_k127_32327_33 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000008052 136.0
TLS3_k127_32327_34 transcriptional regulator - - - 0.00000000000000000000000002043 114.0
TLS3_k127_32327_35 PFAM Iron permease FTR1 - - - 0.00000000000000000000001 112.0
TLS3_k127_32327_36 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.00000000000000000000001375 101.0
TLS3_k127_32327_37 Polymorphic membrane protein, Chlamydia - - - 0.00000000003257 78.0
TLS3_k127_32327_38 Protein of unknown function (DUF3108) - - - 0.00000001622 66.0
TLS3_k127_32327_39 Protein of unknown function (DUF3108) - - - 0.000008319 57.0
TLS3_k127_32327_4 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 542.0
TLS3_k127_32327_40 Peptidase, M56 - - - 0.0001283 54.0
TLS3_k127_32327_41 Belongs to the 'phage' integrase family - - - 0.0003116 44.0
TLS3_k127_32327_5 Belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 502.0
TLS3_k127_32327_6 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 484.0
TLS3_k127_32327_7 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 462.0
TLS3_k127_32327_8 4Fe-4S dicluster domain K17723 - 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 449.0
TLS3_k127_32327_9 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 445.0
TLS3_k127_3293012_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 0.0 1107.0
TLS3_k127_3293012_1 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 1.047e-249 796.0
TLS3_k127_3293012_10 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000000000004845 148.0
TLS3_k127_3293012_11 Hydrogenase/urease nickel incorporation, metallochaperone, hypA K04651 - - 0.00000000000000000000000000000000001038 139.0
TLS3_k127_3293012_12 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000009002 121.0
TLS3_k127_3293012_13 YceI-like domain - - - 0.000000000000000000000000005617 118.0
TLS3_k127_3293012_2 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 3.449e-208 651.0
TLS3_k127_3293012_3 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 446.0
TLS3_k127_3293012_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 322.0
TLS3_k127_3293012_5 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 317.0
TLS3_k127_3293012_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003065 282.0
TLS3_k127_3293012_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002753 252.0
TLS3_k127_3293012_8 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000000000000000000000001074 187.0
TLS3_k127_3293012_9 iron-sulfur cluster assembly - - - 0.0000000000000000000000000000000000000000001131 167.0
TLS3_k127_3324021_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 427.0
TLS3_k127_3324021_1 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 387.0
TLS3_k127_3324021_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000007613 235.0
TLS3_k127_3324021_3 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000001244 201.0
TLS3_k127_3324021_4 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000004832 195.0
TLS3_k127_3383504_0 Vitamin B12 dependent methionine synthase, activation domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1368.0
TLS3_k127_3383504_1 Male sterility protein K01897 - 6.2.1.3 0.0 1313.0
TLS3_k127_3383504_10 epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 297.0
TLS3_k127_3383504_11 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001257 248.0
TLS3_k127_3383504_12 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000007399 244.0
TLS3_k127_3383504_13 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.00000000000000000000000000000000000000000000000000000000000005871 225.0
TLS3_k127_3383504_14 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000004548 211.0
TLS3_k127_3383504_15 Domain of unknown function (DUF4162) K01990 - - 0.0000000000000000000000000000000000000000000000000000005476 206.0
TLS3_k127_3383504_16 Heat shock protein DnaJ domain protein - - - 0.00000000000000000000000000000000000000000000001066 187.0
TLS3_k127_3383504_17 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000005614 178.0
TLS3_k127_3383504_18 Transport permease protein K01992 - - 0.0000000000000000000000000000000000008345 149.0
TLS3_k127_3383504_19 Tetratricopeptide repeat - - - 0.0000000000000000000000000000283 127.0
TLS3_k127_3383504_2 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 1.011e-288 915.0
TLS3_k127_3383504_20 Sigma-70 region 2 K03088 - - 0.00000000000000000001695 100.0
TLS3_k127_3383504_21 Peptidase M16 K07263,K07623 - - 0.000000000000000002296 98.0
TLS3_k127_3383504_22 Methionine biosynthesis protein MetW - - - 0.00000000000002102 81.0
TLS3_k127_3383504_23 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000001265 78.0
TLS3_k127_3383504_24 Peptidase family S41 - - - 0.000000007954 69.0
TLS3_k127_3383504_3 Domain of unknown function (DUF2088) - - - 7.471e-224 704.0
TLS3_k127_3383504_4 Tetratricopeptide repeat - - - 1.198e-199 640.0
TLS3_k127_3383504_5 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 499.0
TLS3_k127_3383504_6 PFAM aminotransferase, class I K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 389.0
TLS3_k127_3383504_7 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 336.0
TLS3_k127_3383504_8 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 320.0
TLS3_k127_3383504_9 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 312.0
TLS3_k127_34215_0 helicase activity - - - 0.0 1071.0
TLS3_k127_34215_1 PFAM D-aminoacylase, C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 552.0
TLS3_k127_34215_10 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000001197 267.0
TLS3_k127_34215_11 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002381 261.0
TLS3_k127_34215_12 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000000000000002169 183.0
TLS3_k127_34215_13 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000000000002372 164.0
TLS3_k127_34215_14 cellulose binding - - - 0.000000000003871 68.0
TLS3_k127_34215_15 - - - - 0.000005658 49.0
TLS3_k127_34215_2 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007028 523.0
TLS3_k127_34215_3 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 441.0
TLS3_k127_34215_4 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 406.0
TLS3_k127_34215_5 Belongs to the ABC transporter superfamily K02010,K10112 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006725 386.0
TLS3_k127_34215_6 glycerophosphodiester transmembrane transport K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009281 308.0
TLS3_k127_34215_7 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004808 284.0
TLS3_k127_34215_8 PFAM Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003701 278.0
TLS3_k127_34215_9 transmembrane transport K02025,K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009675 278.0
TLS3_k127_3451181_0 Ornithine cyclodeaminase/mu-crystallin family K21721 - 1.5.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 338.0
TLS3_k127_3451181_1 Peptidase family S51 K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 286.0
TLS3_k127_3451181_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000007281 176.0
TLS3_k127_3451181_3 Chromate resistance exported protein - - - 0.0000001166 54.0
TLS3_k127_3499120_0 CarboxypepD_reg-like domain - - - 6.759e-219 725.0
TLS3_k127_3499120_1 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.00000000000002526 75.0
TLS3_k127_3499675_0 Carboxypeptidase regulatory-like domain - - - 4.175e-275 876.0
TLS3_k127_3499675_1 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000782 334.0
TLS3_k127_3499675_10 Protein of unknown function with PCYCGC motif - - - 0.000000000000000009523 91.0
TLS3_k127_3499675_11 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain K21826 - - 0.00000000000002886 80.0
TLS3_k127_3499675_12 chaperone-mediated protein folding - - - 0.00000000081 71.0
TLS3_k127_3499675_14 Multicopper oxidase - - - 0.0009538 45.0
TLS3_k127_3499675_2 Bilirubin oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 328.0
TLS3_k127_3499675_3 Multicopper oxidase K14588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000338 240.0
TLS3_k127_3499675_4 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000001643 224.0
TLS3_k127_3499675_5 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000003807 204.0
TLS3_k127_3499675_6 SCO1/SenC - - - 0.00000000000000000000000000000000000000000000000000000000883 205.0
TLS3_k127_3499675_7 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000001499 169.0
TLS3_k127_3499675_8 SCO1/SenC K07152 - - 0.000000000000000000000000000000003133 136.0
TLS3_k127_3499675_9 Thioredoxin-like K02199 - - 0.0000000000000000001332 96.0
TLS3_k127_351268_0 DNA polymerase beta thumb K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 552.0
TLS3_k127_351268_1 PFAM Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007946 394.0
TLS3_k127_351268_2 enzyme related to lactoylglutathione lyase K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001292 268.0
TLS3_k127_351268_3 - - - - 0.00000000000000000000000000000000000000000000000000000002399 206.0
TLS3_k127_351268_4 EamA-like transporter family K07790 - - 0.000000000000000000000000000000000000000000000000000001299 203.0
TLS3_k127_351268_5 PFAM Histidine triad (HIT) protein K02503 - - 0.00000000000000000000000000000000000000000000000002513 183.0
TLS3_k127_351268_6 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000002358 143.0
TLS3_k127_351268_7 - - - - 0.0000000002917 69.0
TLS3_k127_3537369_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K03520,K11177 - 1.17.1.4,1.2.5.3 0.0 1316.0
TLS3_k127_3537369_1 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004069 624.0
TLS3_k127_3537369_10 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001795 250.0
TLS3_k127_3537369_11 XdhC Rossmann domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001304 239.0
TLS3_k127_3537369_12 Protein of unknown function (DUF2167) - - - 0.00000000000000000000000000000000000000000000000000000000000003296 224.0
TLS3_k127_3537369_13 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000000000000002567 208.0
TLS3_k127_3537369_14 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000002288 165.0
TLS3_k127_3537369_15 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.000000000000000000000000000000000000000007811 160.0
TLS3_k127_3537369_16 periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000009976 160.0
TLS3_k127_3537369_17 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000004439 153.0
TLS3_k127_3537369_18 SUF system FeS assembly protein, NifU family K04488 - - 0.00000000000000000000000000003238 120.0
TLS3_k127_3537369_19 Thioredoxin-like - - - 0.000000000000000000000000007715 122.0
TLS3_k127_3537369_2 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000522 528.0
TLS3_k127_3537369_20 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000000000000001182 110.0
TLS3_k127_3537369_21 - - - - 0.00000000005213 74.0
TLS3_k127_3537369_3 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 506.0
TLS3_k127_3537369_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005861 397.0
TLS3_k127_3537369_5 Associated with various cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 376.0
TLS3_k127_3537369_6 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 356.0
TLS3_k127_3537369_7 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007317 358.0
TLS3_k127_3537369_8 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 306.0
TLS3_k127_3537369_9 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003842 273.0
TLS3_k127_3578371_0 TonB dependent receptor K16091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 619.0
TLS3_k127_3578371_1 - - - - 0.000007344 53.0
TLS3_k127_3599656_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702,K08999 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 5.481e-266 833.0
TLS3_k127_3599656_1 Catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate K00294 - 1.2.1.88 2.378e-211 668.0
TLS3_k127_3599656_10 Lysin motif - - - 0.0000000000000000000000000000000000000000000000000000000000004507 221.0
TLS3_k127_3599656_11 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000011 202.0
TLS3_k127_3599656_12 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000001862 200.0
TLS3_k127_3599656_13 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000004678 184.0
TLS3_k127_3599656_14 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000003131 166.0
TLS3_k127_3599656_15 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000626 181.0
TLS3_k127_3599656_16 Alpha/beta hydrolase family K07020 - - 0.000000000000000000000000000000000000000008604 162.0
TLS3_k127_3599656_17 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000002402 155.0
TLS3_k127_3599656_18 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000007366 150.0
TLS3_k127_3599656_19 TIGRFAM Outer membrane assembly lipoprotein YfiO K05807 - - 0.0000000000000000000000000000003602 139.0
TLS3_k127_3599656_2 PFAM FAD linked oxidase domain protein K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 499.0
TLS3_k127_3599656_20 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000002998 113.0
TLS3_k127_3599656_21 Cysteine-rich secretory protein family - - - 0.0000000000000000000005496 103.0
TLS3_k127_3599656_22 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000001187 99.0
TLS3_k127_3599656_23 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000003089 77.0
TLS3_k127_3599656_25 serine threonine protein kinase K12132 - 2.7.11.1 0.0007406 50.0
TLS3_k127_3599656_3 Replicative DNA helicase K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008601 443.0
TLS3_k127_3599656_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 439.0
TLS3_k127_3599656_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 404.0
TLS3_k127_3599656_6 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 314.0
TLS3_k127_3599656_7 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 303.0
TLS3_k127_3599656_8 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001301 286.0
TLS3_k127_3599656_9 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004951 258.0
TLS3_k127_3612386_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 457.0
TLS3_k127_3612386_1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 403.0
TLS3_k127_3612386_2 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 355.0
TLS3_k127_3612386_3 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001341 282.0
TLS3_k127_3612386_4 Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000001868 225.0
TLS3_k127_3612386_5 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000001379 217.0
TLS3_k127_3612386_6 Glycosyl transferase, family 2 K07011 - - 0.00000000000000000000000000000000000000002574 164.0
TLS3_k127_3612386_7 Protein of unknown function (DUF3108) - - - 0.000000009394 63.0
TLS3_k127_3612386_8 PFAM peptidase S1 and S6, chymotrypsin Hap - - - 0.00002196 55.0
TLS3_k127_3614131_0 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 436.0
TLS3_k127_3614131_1 PDZ DHR GLGF domain protein - - - 0.00000000000000000000000000001526 132.0
TLS3_k127_3614131_2 C4-type zinc ribbon domain K07164,K22391 - 3.5.4.16 0.000000000000000000000558 105.0
TLS3_k127_3614131_3 YceI-like domain - - - 0.00007302 46.0
TLS3_k127_3614388_0 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 379.0
TLS3_k127_3614388_1 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000169 206.0
TLS3_k127_3614388_2 NfeD-like C-terminal, partner-binding - - - 0.00000000000000003179 90.0
TLS3_k127_3616545_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.0 1035.0
TLS3_k127_3616545_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 616.0
TLS3_k127_3616545_2 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 464.0
TLS3_k127_3616545_3 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 441.0
TLS3_k127_3616545_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000005797 205.0
TLS3_k127_3616545_5 protein catabolic process K13527 - - 0.000000000000000000000000000000000000000000006 181.0
TLS3_k127_3616545_7 - - - - 0.000000000538 70.0
TLS3_k127_3624198_0 transport - - - 0.0 1141.0
TLS3_k127_3624198_1 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000001045 233.0
TLS3_k127_3624198_2 dioxygenase activity - - - 0.0000000000000000000000000000007488 132.0
TLS3_k127_3624198_3 Methyltransferase domain - - - 0.000488 51.0
TLS3_k127_3636010_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1220.0
TLS3_k127_3636010_1 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000887 376.0
TLS3_k127_3636010_2 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000002094 218.0
TLS3_k127_3636010_3 AMP binding - - - 0.0000000000006275 79.0
TLS3_k127_3636010_4 - - - - 0.0000000003144 63.0
TLS3_k127_363901_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 2.283e-247 773.0
TLS3_k127_363901_1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 1.046e-204 643.0
TLS3_k127_363901_10 Tryptophan halogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002218 251.0
TLS3_k127_363901_11 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000004894 239.0
TLS3_k127_363901_12 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000009293 213.0
TLS3_k127_363901_13 PFAM Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000003997 190.0
TLS3_k127_363901_14 Involved in DNA repair and RecF pathway recombination K03474,K03584 GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 0.000000000000000000000000000000000000004753 155.0
TLS3_k127_363901_15 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000403 153.0
TLS3_k127_363901_16 Protein of unknown function (DUF402) K07586 - - 0.000000000000000003097 90.0
TLS3_k127_363901_17 - - - - 0.0000000000000001317 85.0
TLS3_k127_363901_18 PFAM Fibronectin, type III domain K01179,K06882 - 3.2.1.4 0.000000000003924 78.0
TLS3_k127_363901_19 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000007689 58.0
TLS3_k127_363901_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 3.475e-203 642.0
TLS3_k127_363901_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 557.0
TLS3_k127_363901_4 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006016 541.0
TLS3_k127_363901_5 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 413.0
TLS3_k127_363901_6 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 291.0
TLS3_k127_363901_7 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001886 275.0
TLS3_k127_363901_8 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000004203 248.0
TLS3_k127_363901_9 Permease, YjgP YjgQ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000529 267.0
TLS3_k127_3717551_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 558.0
TLS3_k127_3717551_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 478.0
TLS3_k127_3717551_10 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000001907 83.0
TLS3_k127_3717551_11 Protein of unknown function (DUF3667) - - - 0.0000000000002571 80.0
TLS3_k127_3717551_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 412.0
TLS3_k127_3717551_3 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 297.0
TLS3_k127_3717551_4 recombinase activity - - - 0.00000000000000000000000000000000000000000000000000002855 198.0
TLS3_k127_3717551_5 YndJ-like protein - - - 0.000000000000000000000000000000000000763 151.0
TLS3_k127_3717551_6 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000001008 140.0
TLS3_k127_3717551_7 - - - - 0.0000000000000000000000000001187 121.0
TLS3_k127_3717551_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000246 102.0
TLS3_k127_3717551_9 self proteolysis - - - 0.00000000000000000004181 100.0
TLS3_k127_375488_0 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 0.0 1044.0
TLS3_k127_375488_1 Belongs to the aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 1.818e-197 627.0
TLS3_k127_3758532_0 class II (D K K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 600.0
TLS3_k127_3758532_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 386.0
TLS3_k127_3758532_2 Arginase family K01476 - 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 335.0
TLS3_k127_3758532_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 317.0
TLS3_k127_3758532_4 Mitochondrial biogenesis AIM24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 297.0
TLS3_k127_3758532_5 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000003443 230.0
TLS3_k127_3758532_6 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00966,K16881 GO:0000166,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0006011,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009225,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0051748,GO:0055086,GO:0070569,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363 2.7.7.13,5.4.2.8 0.000000000000000000000000000000000000000000000008583 185.0
TLS3_k127_3758532_7 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.00000000000000000000000000000000000000148 161.0
TLS3_k127_3758532_8 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000000000000000007825 130.0
TLS3_k127_3758532_9 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000001231 89.0
TLS3_k127_3760526_0 Sortilin, neurotensin receptor 3, - - - 0.0 1385.0
TLS3_k127_3760526_1 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 418.0
TLS3_k127_3760526_2 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 398.0
TLS3_k127_3760526_3 Dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 392.0
TLS3_k127_3760526_4 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 311.0
TLS3_k127_3760526_5 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000008431 188.0
TLS3_k127_3760526_6 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000001606 166.0
TLS3_k127_3760526_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000843 152.0
TLS3_k127_3760526_8 AMP binding - - - 0.00000000000000195 84.0
TLS3_k127_3760526_9 Ferredoxin K04755 - - 0.0000001154 60.0
TLS3_k127_3763989_0 Tetratricopeptide repeat - - - 3.728e-257 829.0
TLS3_k127_3763989_1 COG0380 Trehalose-6-phosphate synthase K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 621.0
TLS3_k127_3763989_10 Transcriptional regulator - - - 0.000000001566 64.0
TLS3_k127_3763989_2 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 517.0
TLS3_k127_3763989_3 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009619 410.0
TLS3_k127_3763989_4 peptidase S8 and S53, subtilisin, kexin, sedolisin K20754 - 3.4.21.111 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 333.0
TLS3_k127_3763989_5 Binding-protein-dependent transport system inner membrane component K02050,K15554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006569 306.0
TLS3_k127_3763989_6 anion transmembrane transporter activity K02049,K15555,K15558 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002248 284.0
TLS3_k127_3763989_7 COG2335, Secreted and surface protein containing fasciclin-like repeats - - - 0.0000000000000000000002062 103.0
TLS3_k127_3763989_8 - - - - 0.00000000000000000000184 96.0
TLS3_k127_3763989_9 - - - - 0.0000000000000000009921 88.0
TLS3_k127_3812870_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 3.596e-217 689.0
TLS3_k127_3812870_1 HELICc2 K03722 - 3.6.4.12 3.989e-198 636.0
TLS3_k127_3812870_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 556.0
TLS3_k127_3812870_3 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 479.0
TLS3_k127_3812870_4 peptidyl-tyrosine sulfation K03217,K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007326 276.0
TLS3_k127_3812870_5 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000009711 172.0
TLS3_k127_3812870_6 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000001436 136.0
TLS3_k127_3812870_7 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000000000000000008143 96.0
TLS3_k127_3812870_8 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000004837 83.0
TLS3_k127_3858973_0 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000001369 173.0
TLS3_k127_3858973_1 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000004986 153.0
TLS3_k127_3858973_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.0000000000000000000000005653 117.0
TLS3_k127_3858973_3 epimerase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000001793 113.0
TLS3_k127_3858973_4 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000008397 92.0
TLS3_k127_3887618_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1211.0
TLS3_k127_3887618_1 Carbon starvation protein K06200 - - 8.65e-217 689.0
TLS3_k127_3887618_10 outer membrane autotransporter barrel domain protein - - - 0.000001098 57.0
TLS3_k127_3887618_2 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004627 282.0
TLS3_k127_3887618_3 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000001297 235.0
TLS3_k127_3887618_4 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.000000000000000000000000000000000000000000004162 176.0
TLS3_k127_3887618_5 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000001698 154.0
TLS3_k127_3887618_6 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000008653 144.0
TLS3_k127_3887618_7 PFAM BioY protein K03523 - - 0.00000000000000000000000000000000000199 146.0
TLS3_k127_3887618_8 PFAM Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000004239 140.0
TLS3_k127_3887618_9 Domain of unknown function (DUF4328) - - - 0.0000000000000000003897 96.0
TLS3_k127_39276_0 CHASE3 domain - - - 4.226e-247 778.0
TLS3_k127_39276_1 Domains REC, sigma54 interaction, HTH8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 453.0
TLS3_k127_39276_2 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000003702 203.0
TLS3_k127_39276_3 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000001029 200.0
TLS3_k127_39276_4 Ankyrin repeat K19044 GO:0003674,GO:0003824,GO:0004842,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:0140096,GO:1901564 2.3.2.27 0.00000002714 59.0
TLS3_k127_392801_0 PFAM Type II secretion system protein E K02652 - - 4.19e-219 692.0
TLS3_k127_392801_1 Carboxypeptidase regulatory-like domain - - - 2.316e-202 670.0
TLS3_k127_392801_10 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008726 273.0
TLS3_k127_392801_11 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007025 265.0
TLS3_k127_392801_12 Belongs to the DapA family K01714,K22397 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575 4.1.2.28,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000002299 256.0
TLS3_k127_392801_13 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000003346 244.0
TLS3_k127_392801_14 isomerase activity K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000001656 238.0
TLS3_k127_392801_15 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000006317 227.0
TLS3_k127_392801_16 ferredoxin-NADP+ reductase activity K00384,K21567 - 1.18.1.2,1.19.1.1,1.8.1.9 0.00000000000000000000000000000000000000000000000000007238 199.0
TLS3_k127_392801_17 Participates in transcription elongation, termination and antitermination - - - 0.00000000000000000000000000000000000000000000000000008188 203.0
TLS3_k127_392801_18 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000286 190.0
TLS3_k127_392801_19 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000002656 179.0
TLS3_k127_392801_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 546.0
TLS3_k127_392801_20 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000001021 177.0
TLS3_k127_392801_21 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000001492 166.0
TLS3_k127_392801_22 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000004019 176.0
TLS3_k127_392801_23 Rossmann-like domain - - - 0.0000000000000000000000000000000000000000002662 169.0
TLS3_k127_392801_24 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000007014 149.0
TLS3_k127_392801_25 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000192 135.0
TLS3_k127_392801_26 Secretin and TonB N terminus short domain K02453 - - 0.000000000000000000000000000007387 138.0
TLS3_k127_392801_27 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000001101 119.0
TLS3_k127_392801_28 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000001242 121.0
TLS3_k127_392801_29 Biotin-requiring enzyme - - - 0.00000000000000000000469 101.0
TLS3_k127_392801_3 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 502.0
TLS3_k127_392801_30 Pilus assembly protein K02662 - - 0.00000001497 66.0
TLS3_k127_392801_31 - - - - 0.000001676 54.0
TLS3_k127_392801_32 Peptidase M16 inactive domain - - - 0.000007433 56.0
TLS3_k127_392801_33 AntiSigma factor - - - 0.0002104 51.0
TLS3_k127_392801_34 - - - - 0.0003284 46.0
TLS3_k127_392801_35 - - - - 0.0007643 52.0
TLS3_k127_392801_4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850,K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 415.0
TLS3_k127_392801_5 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 390.0
TLS3_k127_392801_6 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005418 346.0
TLS3_k127_392801_7 Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH K22136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 324.0
TLS3_k127_392801_8 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 302.0
TLS3_k127_392801_9 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001194 276.0
TLS3_k127_3933027_0 PFAM peptidase S9 prolyl oligopeptidase active site domain protein K01322,K01354 - 3.4.21.26,3.4.21.83 1.034e-260 821.0
TLS3_k127_3933027_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 431.0
TLS3_k127_3933027_2 phosphoprotein phosphatase activity K07313 - 3.1.3.16 0.0000000000000000000000000000000000007475 148.0
TLS3_k127_3933027_4 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000001753 70.0
TLS3_k127_4013921_0 Tricorn protease homolog K08676 - - 0.0 1524.0
TLS3_k127_4013921_1 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1347.0
TLS3_k127_4013921_10 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 336.0
TLS3_k127_4013921_11 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 316.0
TLS3_k127_4013921_12 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000003961 264.0
TLS3_k127_4013921_13 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009959 250.0
TLS3_k127_4013921_14 Belongs to the MlaE permease family K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000005456 233.0
TLS3_k127_4013921_15 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000001665 217.0
TLS3_k127_4013921_16 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000000004871 213.0
TLS3_k127_4013921_17 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000002 187.0
TLS3_k127_4013921_18 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000002277 186.0
TLS3_k127_4013921_19 recA bacterial DNA recombination protein - - - 0.0000000000000000000000000000000000000000000000002565 186.0
TLS3_k127_4013921_2 Tricorn protease homolog - - - 0.0 1335.0
TLS3_k127_4013921_20 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000001669 180.0
TLS3_k127_4013921_21 Peptidase M56 - - - 0.000000000000000000000000000009915 133.0
TLS3_k127_4013921_22 PA domain - - - 0.0000002149 63.0
TLS3_k127_4013921_3 Aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 607.0
TLS3_k127_4013921_4 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 461.0
TLS3_k127_4013921_5 Peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 391.0
TLS3_k127_4013921_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 354.0
TLS3_k127_4013921_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 338.0
TLS3_k127_4013921_8 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002576 340.0
TLS3_k127_4013921_9 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 338.0
TLS3_k127_4017646_0 MacB-like periplasmic core domain - - - 5.211e-241 769.0
TLS3_k127_4017646_1 MacB-like periplasmic core domain - - - 4.511e-221 711.0
TLS3_k127_4017646_10 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 632.0
TLS3_k127_4017646_11 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 615.0
TLS3_k127_4017646_12 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008117 611.0
TLS3_k127_4017646_13 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008933 608.0
TLS3_k127_4017646_14 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 590.0
TLS3_k127_4017646_15 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 590.0
TLS3_k127_4017646_16 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 578.0
TLS3_k127_4017646_17 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 568.0
TLS3_k127_4017646_18 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006655 565.0
TLS3_k127_4017646_19 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 537.0
TLS3_k127_4017646_2 MacB-like periplasmic core domain - - - 1.225e-218 705.0
TLS3_k127_4017646_20 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 535.0
TLS3_k127_4017646_21 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 543.0
TLS3_k127_4017646_22 ABC transporter K10441 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 511.0
TLS3_k127_4017646_23 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 511.0
TLS3_k127_4017646_24 Converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 430.0
TLS3_k127_4017646_25 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 432.0
TLS3_k127_4017646_26 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 405.0
TLS3_k127_4017646_27 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 382.0
TLS3_k127_4017646_28 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 349.0
TLS3_k127_4017646_29 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 325.0
TLS3_k127_4017646_3 efflux transmembrane transporter activity K02004 - - 1.048e-212 686.0
TLS3_k127_4017646_30 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004563 270.0
TLS3_k127_4017646_31 Peptidase M56 - - - 0.0000000000000000000000000000000000000000000008866 180.0
TLS3_k127_4017646_32 YceI-like domain - - - 0.00000000000000000000000003261 115.0
TLS3_k127_4017646_33 efflux transmembrane transporter activity - - - 0.0000000000000003988 81.0
TLS3_k127_4017646_4 efflux transmembrane transporter activity K02004 - - 8.681e-211 682.0
TLS3_k127_4017646_5 efflux transmembrane transporter activity K02004 - - 3.142e-210 680.0
TLS3_k127_4017646_6 FtsX-like permease family - - - 5.107e-208 674.0
TLS3_k127_4017646_7 MacB-like periplasmic core domain - - - 2.018e-206 668.0
TLS3_k127_4017646_8 efflux transmembrane transporter activity K02004 - - 7.396e-206 666.0
TLS3_k127_4017646_9 efflux transmembrane transporter activity K02004 - - 8.947e-199 647.0
TLS3_k127_4036205_0 Trehalase K01194 - 3.2.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008561 598.0
TLS3_k127_4036205_1 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 364.0
TLS3_k127_4036205_2 phosphoesterase, PA-phosphatase related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006454 374.0
TLS3_k127_4036205_3 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000003703 218.0
TLS3_k127_4036205_4 helix_turn_helix, Lux Regulon - - - 0.0000000272 63.0
TLS3_k127_4036205_5 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0006898 49.0
TLS3_k127_404718_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 4.985e-292 912.0
TLS3_k127_404718_1 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 503.0
TLS3_k127_404718_10 cell redox homeostasis - - - 0.0000000000000000000258 98.0
TLS3_k127_404718_11 antisigma factor binding K04749,K06378 - - 0.000004605 53.0
TLS3_k127_404718_2 Winged helix DNA-binding domain K09927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 476.0
TLS3_k127_404718_3 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 422.0
TLS3_k127_404718_4 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 392.0
TLS3_k127_404718_5 Beta-lactamase class C and other penicillin binding K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 306.0
TLS3_k127_404718_6 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000001139 204.0
TLS3_k127_404718_7 PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin - - - 0.0000000000000000000000000008685 128.0
TLS3_k127_404718_8 Plasmid stabilization system - - - 0.000000000000000000000006164 104.0
TLS3_k127_404881_0 COG0226 ABC-type phosphate transport system periplasmic K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 437.0
TLS3_k127_404881_1 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 402.0
TLS3_k127_404881_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 395.0
TLS3_k127_404881_3 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 396.0
TLS3_k127_404881_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 358.0
TLS3_k127_404881_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 345.0
TLS3_k127_404881_6 Transcriptional regulatory protein, C terminal K07667 - - 0.00000008635 58.0
TLS3_k127_405117_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 3.429e-231 734.0
TLS3_k127_405117_1 glutamine synthetase K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 1.586e-207 655.0
TLS3_k127_405117_2 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 488.0
TLS3_k127_405117_3 pfam abc K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 312.0
TLS3_k127_405117_4 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003245 321.0
TLS3_k127_405117_5 Deoxyhypusine synthase K00809 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001876 286.0
TLS3_k127_405117_6 CHRD domain - - - 0.000000000000000000000000000000000000001142 158.0
TLS3_k127_405117_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000001118 155.0
TLS3_k127_405117_8 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.0000000000000000000000000000002134 138.0
TLS3_k127_405117_9 diguanylate cyclase - - - 0.0000000000000000000000004136 119.0
TLS3_k127_409646_0 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K07291 - 2.7.8.34 0.00000000000000000000000000000000000000000000000000374 190.0
TLS3_k127_409646_2 Protein of unknown function (DUF1572) - - - 0.00000000000000000000000000000000297 138.0
TLS3_k127_409646_3 - - - - 0.00000000000000000000000001705 110.0
TLS3_k127_409646_4 Protein of unknown function (DUF971) K03593 - - 0.0000000000000000000000005133 107.0
TLS3_k127_409646_5 Protein of unknown function (DUF2847) - - - 0.000000000000000001073 90.0
TLS3_k127_411828_0 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 532.0
TLS3_k127_411828_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 476.0
TLS3_k127_411828_10 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002551 254.0
TLS3_k127_411828_11 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03644,K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181,2.8.1.8 0.000000000000000000000000000000000000000000000000000000000005075 214.0
TLS3_k127_411828_12 hydrolase of the alpha beta K07018 - - 0.00000000000000000000000000000000000000000000000000001473 196.0
TLS3_k127_411828_13 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000002771 207.0
TLS3_k127_411828_14 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000001269 183.0
TLS3_k127_411828_15 AhpC/TSA family - - - 0.00000000000000000000000000000000000000000006812 165.0
TLS3_k127_411828_16 photosynthesis - - - 0.0000000000000000000000000000000000000000009378 161.0
TLS3_k127_411828_17 Belongs to the Fur family K09825 - - 0.0000000000000000000000000000001265 128.0
TLS3_k127_411828_18 Thioesterase superfamily K10806 - - 0.00000000000000000000000000001185 123.0
TLS3_k127_411828_19 Domain of unknown function (DUF4112) - - - 0.00000000000000000000000000001861 124.0
TLS3_k127_411828_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 394.0
TLS3_k127_411828_20 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000005598 108.0
TLS3_k127_411828_21 Recombinase - - - 0.000000000000000000114 94.0
TLS3_k127_411828_23 Polymer-forming cytoskeletal - - - 0.000000000000000156 88.0
TLS3_k127_411828_24 recombinase activity - - - 0.0000004394 53.0
TLS3_k127_411828_3 Recombinase zinc beta ribbon domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009069 375.0
TLS3_k127_411828_4 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 353.0
TLS3_k127_411828_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 352.0
TLS3_k127_411828_6 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 351.0
TLS3_k127_411828_7 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001003 275.0
TLS3_k127_411828_9 PFAM KWG Leptospira - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003309 274.0
TLS3_k127_4173288_0 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 598.0
TLS3_k127_4173288_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 493.0
TLS3_k127_4173288_2 RmlD substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 425.0
TLS3_k127_4173288_3 PFAM Glycosyl transferase family 2 K10012 - 2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 370.0
TLS3_k127_4173288_4 PFAM sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 310.0
TLS3_k127_4173288_5 Highly conserved protein containing a thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 300.0
TLS3_k127_4173288_6 Protein of unknown function (DUF354) K09726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005813 252.0
TLS3_k127_4173288_7 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002735 240.0
TLS3_k127_4173288_8 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000007805 231.0
TLS3_k127_4173288_9 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000009751 230.0
TLS3_k127_4262751_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 5.831e-264 824.0
TLS3_k127_4262751_1 PA domain - - - 4.064e-241 759.0
TLS3_k127_4262751_2 tRNA synthetases class I (E and Q), catalytic domain K01885 - 6.1.1.17 2.839e-204 649.0
TLS3_k127_4262751_3 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000001193 244.0
TLS3_k127_4262751_4 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000001198 160.0
TLS3_k127_4262751_5 Histidine kinase - - - 0.00000000000000000000000000000000621 135.0
TLS3_k127_4307410_0 amino acid - - - 7.578e-257 811.0
TLS3_k127_4307410_1 amino acid - - - 8.827e-257 807.0
TLS3_k127_4307410_2 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009225 413.0
TLS3_k127_4307410_3 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 370.0
TLS3_k127_4307410_4 PspA/IM30 family K03969 - - 0.0000000000000000000000000000000000000002667 158.0
TLS3_k127_4307410_5 Probable zinc-ribbon domain - - - 0.000000000000000000000000000001196 124.0
TLS3_k127_4307410_6 - - - - 0.0000000000000354 83.0
TLS3_k127_4333659_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 7.744e-228 718.0
TLS3_k127_4333659_1 PFAM cobalamin B12-binding domain protein K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000003917 205.0
TLS3_k127_4333659_2 Belongs to the enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000005765 212.0
TLS3_k127_4333659_3 - - - - 0.0000000000000000026 85.0
TLS3_k127_4334013_0 SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 K00239 - 1.3.5.1,1.3.5.4 2.648e-273 853.0
TLS3_k127_4334013_1 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 488.0
TLS3_k127_4334013_10 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000004171 205.0
TLS3_k127_4334013_11 - - - - 0.00000000000000000000000000000000000000000000000000002283 210.0
TLS3_k127_4334013_12 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.00000000000000000000000000000000000000000000002187 178.0
TLS3_k127_4334013_13 EXOIII K02342 - 2.7.7.7 0.000000000000000000000000000000000000003002 161.0
TLS3_k127_4334013_14 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000000000000004847 153.0
TLS3_k127_4334013_15 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.000000000000000000000000000000002715 135.0
TLS3_k127_4334013_16 PFAM SNARE associated protein - - - 0.0000000000000000005722 94.0
TLS3_k127_4334013_17 SNARE associated Golgi protein - - - 0.000000000000000004608 92.0
TLS3_k127_4334013_18 - - - - 0.00000000001755 75.0
TLS3_k127_4334013_19 RDD family - - - 0.000000004082 63.0
TLS3_k127_4334013_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 455.0
TLS3_k127_4334013_3 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 383.0
TLS3_k127_4334013_4 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 344.0
TLS3_k127_4334013_5 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 331.0
TLS3_k127_4334013_6 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 319.0
TLS3_k127_4334013_7 SPFH Band 7 PHB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 297.0
TLS3_k127_4334013_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000001162 272.0
TLS3_k127_4334013_9 orotate phosphoribosyltransferase activity K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000002652 222.0
TLS3_k127_4336934_0 PFAM Pyridoxal-dependent decarboxylase conserved domain K01580,K01593,K13745 - 4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 566.0
TLS3_k127_4336934_1 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008854 494.0
TLS3_k127_4336934_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 333.0
TLS3_k127_4336934_3 3'(2'),5'-bisphosphate nucleotidase activity K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000001043 245.0
TLS3_k127_4336934_4 Histidine kinase - - - 0.0000000000000000000000000000000003375 151.0
TLS3_k127_4336934_5 membrane - - - 0.00000000000000000000000000000006371 128.0
TLS3_k127_4336934_6 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000007886 95.0
TLS3_k127_4343742_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 354.0
TLS3_k127_4343742_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000008399 204.0
TLS3_k127_4343742_2 Tetratricopeptide TPR_2 repeat protein K12600 - - 0.00000000000000006554 87.0
TLS3_k127_4343742_3 Pilus assembly protein PilX K02673 - - 0.00000000001812 77.0
TLS3_k127_4343742_4 Pfam:N_methyl_2 - - - 0.0008194 49.0
TLS3_k127_4355868_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 4.975e-205 663.0
TLS3_k127_4355868_1 BON domain K04065 - - 0.0000000000000000000000000000000000000000000000000000000000001799 220.0
TLS3_k127_4355868_2 Hsp20/alpha crystallin family - - - 0.000000000000000000000000000002254 124.0
TLS3_k127_4355868_3 - - - - 0.00000000000000000000839 93.0
TLS3_k127_4355868_4 ZIP Zinc transporter K16267 - - 0.0000000000000000003826 90.0
TLS3_k127_4355868_5 - - - - 0.000000000002993 67.0
TLS3_k127_4365620_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000001794 257.0
TLS3_k127_4365620_1 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.0000000000000000000000000000000000000000000000000000004365 201.0
TLS3_k127_4365620_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000006045 186.0
TLS3_k127_4365620_3 Wd40 repeat-containing protein - - - 0.00000000003599 74.0
TLS3_k127_4365679_0 PFAM MgtC SapB transporter K07507 - - 0.00000000000000000000000000000000000000000000000006242 182.0
TLS3_k127_4365679_1 2OG-Fe(II) oxygenase superfamily K07336,K07394 - - 0.0000000000000000000000000000000000000000008362 164.0
TLS3_k127_4365679_2 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000000000004529 138.0
TLS3_k127_4365679_3 - - - - 0.00000000000000000000000000003221 122.0
TLS3_k127_4365679_4 Dihydroorotate dehydrogenase K00254 - 1.3.5.2 0.00000000000000000000000197 106.0
TLS3_k127_4365679_5 protein conserved in bacteria K07192 - - 0.000000000000000000000012 110.0
TLS3_k127_4368503_0 WD domain, G-beta repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006351 578.0
TLS3_k127_4368503_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 319.0
TLS3_k127_4394846_0 Carboxypeptidase regulatory-like domain - - - 0.0 1165.0
TLS3_k127_4394846_1 Cytochrome c-type biogenesis protein CcmF K02198 - - 6.338e-316 979.0
TLS3_k127_4394846_10 Cytochrome c-type biogenesis protein K02200 - - 0.000000000000000000000000000000000000000000000000000000000006478 218.0
TLS3_k127_4394846_11 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000000000000000000000000000000000009911 212.0
TLS3_k127_4394846_12 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000000000000000003237 194.0
TLS3_k127_4394846_13 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000002305 184.0
TLS3_k127_4394846_14 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000002909 160.0
TLS3_k127_4394846_15 Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat - - - 0.000000007767 69.0
TLS3_k127_4394846_16 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.00006212 48.0
TLS3_k127_4394846_17 Tetratricopeptide repeat protein - - - 0.0003955 50.0
TLS3_k127_4394846_2 copper-translocating P-type ATPase K17686 - 3.6.3.54 4.034e-311 971.0
TLS3_k127_4394846_3 hydrolase, family 3 K05349 - 3.2.1.21 1.616e-269 848.0
TLS3_k127_4394846_4 Putative glucoamylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 420.0
TLS3_k127_4394846_5 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 415.0
TLS3_k127_4394846_6 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 353.0
TLS3_k127_4394846_7 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 302.0
TLS3_k127_4394846_8 oxidoreductase DsbE K02199 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004047 250.0
TLS3_k127_4394846_9 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000029 249.0
TLS3_k127_4405565_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 1.437e-196 625.0
TLS3_k127_4405565_10 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000002857 61.0
TLS3_k127_4405565_11 pyridoxal phosphate binding K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0001674 47.0
TLS3_k127_4405565_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 484.0
TLS3_k127_4405565_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 411.0
TLS3_k127_4405565_5 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 - - 0.0000000000000000000000000000000000000000000008447 169.0
TLS3_k127_4405565_6 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000007338 186.0
TLS3_k127_4405565_7 Forkhead associated domain - - - 0.0000000000000000000000000000000000001508 160.0
TLS3_k127_4405565_8 Ferredoxin - - - 0.0000000000000000000000003532 109.0
TLS3_k127_4405565_9 Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus - - - 0.0000000000000375 79.0
TLS3_k127_4407991_0 efflux transmembrane transporter activity - - - 2.362e-226 726.0
TLS3_k127_4407991_1 RNA pseudouridylate synthase K06177 - 5.4.99.28,5.4.99.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 349.0
TLS3_k127_4407991_2 involved in biosynthesis of extracellular polysaccharides - - - 0.000000000000000000000000000000000000000000000001288 177.0
TLS3_k127_4407991_3 RF-1 domain - - - 0.000000000000000000000000000003086 123.0
TLS3_k127_4407991_4 ORF6N domain - - - 0.0000000000000007663 79.0
TLS3_k127_4417104_0 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006157 302.0
TLS3_k127_4417104_1 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000005268 210.0
TLS3_k127_4417104_2 - - - - 0.000000000000009542 82.0
TLS3_k127_4417104_3 Sh3 type 3 domain protein - - - 0.000000002255 69.0
TLS3_k127_4417104_4 - - - - 0.0000002499 53.0
TLS3_k127_4417104_5 - - - - 0.00000377 49.0
TLS3_k127_4417104_6 Protease with the C-terminal PDZ domain - - - 0.00001146 58.0
TLS3_k127_4458098_0 Nickel-dependent hydrogenase - - - 1.518e-211 664.0
TLS3_k127_4458098_1 coenzyme F420 hydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 388.0
TLS3_k127_4458098_2 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 354.0
TLS3_k127_4458098_3 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000003659 165.0
TLS3_k127_4458098_4 Hydrogenase maturation protease - - - 0.00000000000000000000000000000000000003047 147.0
TLS3_k127_4458098_5 metallopeptidase activity K06212,K06402 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.000000000000000000000000000000000001875 143.0
TLS3_k127_4458098_6 Cell shape determining protein MreB Mrl K03569 - - 0.000000000000004375 82.0
TLS3_k127_4458098_7 eRF1 domain 3 - - - 0.00000645 52.0
TLS3_k127_4467226_0 Tetratricopeptide repeat - - - 1.58e-234 761.0
TLS3_k127_4467226_1 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 518.0
TLS3_k127_4467226_10 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000000000000000000002057 228.0
TLS3_k127_4467226_11 RNA polymerase, sigma-24 subunit, ECF subfamily K02405 - - 0.000000000000000000000000000000000000000000000000000000000002343 215.0
TLS3_k127_4467226_12 ferroxidase activity K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000883 201.0
TLS3_k127_4467226_13 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000001667 188.0
TLS3_k127_4467226_14 Phage integrase, N-terminal SAM-like domain K14059 - - 0.00000000000000000000000000000000000000002634 162.0
TLS3_k127_4467226_15 PFAM von Willebrand factor type A K07114 - - 0.00000000000000000000000006192 121.0
TLS3_k127_4467226_16 TIR domain - - - 0.00000000000000000008913 100.0
TLS3_k127_4467226_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 467.0
TLS3_k127_4467226_3 amino acid peptide transporter K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 474.0
TLS3_k127_4467226_4 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 480.0
TLS3_k127_4467226_5 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 353.0
TLS3_k127_4467226_6 Peptidase family M1 domain K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 338.0
TLS3_k127_4467226_7 Amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 301.0
TLS3_k127_4467226_8 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002832 290.0
TLS3_k127_4467226_9 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000003378 261.0
TLS3_k127_4489741_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 492.0
TLS3_k127_4489741_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 374.0
TLS3_k127_4505375_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 561.0
TLS3_k127_4505375_1 Protein of unknown function (DUF2975) - - - 0.00000000000000000000000000000000000001814 149.0
TLS3_k127_4505375_2 Protein of unknown function (DUF4087) - - - 0.00000000000000000000000000000000003184 140.0
TLS3_k127_4505375_3 Smr domain - - - 0.000000000000000000000000000001473 124.0
TLS3_k127_4505375_4 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000001716 109.0
TLS3_k127_4505375_5 - - - - 0.000000000000000000000000243 111.0
TLS3_k127_4505375_6 - - - - 0.000000000000006721 80.0
TLS3_k127_4505375_7 - - - - 0.0000000004093 63.0
TLS3_k127_4505375_8 TIGRFAM TonB family K03832 - - 0.000000002159 66.0
TLS3_k127_4505375_9 - - - - 0.0001894 49.0
TLS3_k127_4522038_0 transport - - - 1.288e-252 826.0
TLS3_k127_4522038_1 major pilin protein fima - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008163 434.0
TLS3_k127_4522038_10 - - - - 0.00000000000006975 78.0
TLS3_k127_4522038_11 Carboxypeptidase regulatory-like domain - - - 0.0000000003735 64.0
TLS3_k127_4522038_12 zinc-ribbon domain - - - 0.000007988 57.0
TLS3_k127_4522038_2 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 327.0
TLS3_k127_4522038_3 PFAM Peptidase M20 - - - 0.000000000000000000000000000000000000000000000000000000003161 216.0
TLS3_k127_4522038_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000001441 179.0
TLS3_k127_4522038_5 PFAM TM2 domain - - - 0.00000000000000000000000000004946 120.0
TLS3_k127_4522038_6 Protein of unknown function (DUF2752) - - - 0.00000000000000000000000313 107.0
TLS3_k127_4522038_7 O-Antigen ligase K18814 - - 0.000000000000000001116 100.0
TLS3_k127_4522038_8 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000001857 90.0
TLS3_k127_4522038_9 Interferon-induced transmembrane protein - - - 0.0000000000000005805 81.0
TLS3_k127_4539306_0 Peptidase inhibitor I9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 485.0
TLS3_k127_4539306_1 Domain of Unknown function (DUF542) K07322 - - 0.00000000000000000000000000000000000000000000000000000000000000001171 231.0
TLS3_k127_4539615_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.563e-258 811.0
TLS3_k127_4539615_1 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 446.0
TLS3_k127_4539615_2 PFAM Helix-turn-helix, type 11 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 325.0
TLS3_k127_4539615_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002527 283.0
TLS3_k127_4539615_4 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000004446 189.0
TLS3_k127_4539615_5 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000001032 201.0
TLS3_k127_4539615_6 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000001699 167.0
TLS3_k127_4539615_7 - - - - 0.000000000000000000000000000000000001591 143.0
TLS3_k127_4539615_8 hydroperoxide reductase activity K01607 - 4.1.1.44 0.000000000000000000000000000000000513 132.0
TLS3_k127_4539901_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 2.894e-211 674.0
TLS3_k127_4539901_1 Amino acid permease K03294 - - 2.074e-209 662.0
TLS3_k127_4539901_10 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 387.0
TLS3_k127_4539901_11 Major facilitator Superfamily K08223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009424 370.0
TLS3_k127_4539901_12 Heparinase II/III-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 325.0
TLS3_k127_4539901_13 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007591 303.0
TLS3_k127_4539901_14 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005496 280.0
TLS3_k127_4539901_15 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000531 282.0
TLS3_k127_4539901_16 FtsJ-like methyltransferase K06442 GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000001433 258.0
TLS3_k127_4539901_17 Glycosyltransferase like family 2 K16870 - 2.4.1.289 0.0000000000000000000000000000000000000000000000000000000000000000002494 244.0
TLS3_k127_4539901_18 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000001921 216.0
TLS3_k127_4539901_19 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000001033 209.0
TLS3_k127_4539901_2 Dehydrogenase K02030,K03810 - - 5.05e-209 671.0
TLS3_k127_4539901_20 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000001058 184.0
TLS3_k127_4539901_21 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000004809 132.0
TLS3_k127_4539901_22 - - - - 0.0000000000000000000002154 102.0
TLS3_k127_4539901_23 Y_Y_Y domain - - - 0.000000000000000002767 93.0
TLS3_k127_4539901_24 Membrane protein involved in the export of o-antigen and teichoic acid K03328 - - 0.000000000003524 78.0
TLS3_k127_4539901_25 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000002272 73.0
TLS3_k127_4539901_26 von Willebrand factor (vWF) type A domain - - - 0.00000009163 64.0
TLS3_k127_4539901_27 SnoaL-like domain - - - 0.0000003846 60.0
TLS3_k127_4539901_28 Putative addiction module component - - - 0.0000007138 53.0
TLS3_k127_4539901_29 DinB family - - - 0.00005689 52.0
TLS3_k127_4539901_3 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 592.0
TLS3_k127_4539901_4 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 584.0
TLS3_k127_4539901_5 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 536.0
TLS3_k127_4539901_6 DNA polymerase K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 466.0
TLS3_k127_4539901_7 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 452.0
TLS3_k127_4539901_8 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 436.0
TLS3_k127_4539901_9 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 439.0
TLS3_k127_4551902_0 Alpha/beta hydrolase family - - - 3.366e-292 917.0
TLS3_k127_4551902_1 cellulose binding - - - 1.906e-222 693.0
TLS3_k127_4551902_2 ABC transporter K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 363.0
TLS3_k127_4551902_3 Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 355.0
TLS3_k127_4551902_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 317.0
TLS3_k127_4551902_5 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005509 246.0
TLS3_k127_4551902_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003837 228.0
TLS3_k127_4551902_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000008621 180.0
TLS3_k127_4551902_8 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.0000000000000000000000000000000000002234 143.0
TLS3_k127_4569993_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 593.0
TLS3_k127_4569993_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 403.0
TLS3_k127_4569993_10 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000006164 104.0
TLS3_k127_4569993_11 PFAM von Willebrand factor type A - - - 0.0000000000517 75.0
TLS3_k127_4569993_12 snoRNA binding - - - 0.000000005624 64.0
TLS3_k127_4569993_2 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 366.0
TLS3_k127_4569993_3 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 310.0
TLS3_k127_4569993_4 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 302.0
TLS3_k127_4569993_5 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 287.0
TLS3_k127_4569993_6 PFAM Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004092 247.0
TLS3_k127_4569993_7 metalloendopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000142 206.0
TLS3_k127_4569993_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000001992 162.0
TLS3_k127_4569993_9 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000002553 117.0
TLS3_k127_4608027_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 297.0
TLS3_k127_4608027_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006322 272.0
TLS3_k127_4608027_2 CHASE2 - - - 0.000000000000000000000000000000000000000000000000006256 204.0
TLS3_k127_4608027_3 Putative restriction endonuclease - - - 0.0000000000000000000000000000000004892 138.0
TLS3_k127_4608027_4 SET domain K07117 - - 0.0000000000000000000000000000007873 126.0
TLS3_k127_4608356_0 succinate dehydrogenase K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 5.047e-312 962.0
TLS3_k127_4608356_1 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 594.0
TLS3_k127_4608356_10 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000003402 192.0
TLS3_k127_4608356_11 oxidoreductase activity K12511 - - 0.000000000000000000000000000000000000001806 160.0
TLS3_k127_4608356_12 HNH endonuclease - - - 0.0000000000000000000000000000001385 132.0
TLS3_k127_4608356_2 family UPF0027 K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 527.0
TLS3_k127_4608356_3 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 428.0
TLS3_k127_4608356_4 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009529 427.0
TLS3_k127_4608356_5 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 367.0
TLS3_k127_4608356_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 359.0
TLS3_k127_4608356_7 Homoserine dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 299.0
TLS3_k127_4608356_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000002627 222.0
TLS3_k127_4608356_9 Xylose isomerase-like TIM barrel K06606 - 5.3.99.11 0.00000000000000000000000000000000000000000000000000000000000006262 223.0
TLS3_k127_4648366_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 287.0
TLS3_k127_4648366_1 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008645 256.0
TLS3_k127_4648366_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000007205 232.0
TLS3_k127_466232_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 4.442e-222 719.0
TLS3_k127_466232_1 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009033 394.0
TLS3_k127_466232_2 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005649 276.0
TLS3_k127_466232_3 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000007321 136.0
TLS3_k127_466232_4 Yqey-like protein K09117 - - 0.00000000000000000000000000002685 124.0
TLS3_k127_466232_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000001238 70.0
TLS3_k127_4676517_0 Dienelactone hydrolase family - - - 0.0 1162.0
TLS3_k127_4676517_1 Predicted membrane protein (DUF2306) - - - 0.0000000000000000000000000000000000000000000000000000000001301 213.0
TLS3_k127_4676517_2 YhhN family - - - 0.0006995 49.0
TLS3_k127_4699573_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 529.0
TLS3_k127_4699573_1 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 441.0
TLS3_k127_4699573_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 332.0
TLS3_k127_4699573_3 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 295.0
TLS3_k127_4699573_4 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000001874 275.0
TLS3_k127_4699573_5 Phosphoribosyl transferase domain K00760,K15780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000003639 228.0
TLS3_k127_4699573_6 PFAM Ribose galactose isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000004356 164.0
TLS3_k127_4699573_7 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.0000000000000000000000006845 116.0
TLS3_k127_4717197_0 Glycosyl transferase family 2 - - - 2.902e-201 652.0
TLS3_k127_4717197_1 Methyltransferase FkbM domain K21402 - - 0.00000000000000000000000000001385 137.0
TLS3_k127_4717197_3 Protein of unknown function (DUF3298) - - - 0.0000000715 55.0
TLS3_k127_4763239_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0 1358.0
TLS3_k127_4763239_1 peroxiredoxin activity - - - 4.474e-296 917.0
TLS3_k127_4763239_2 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 623.0
TLS3_k127_4763239_3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 452.0
TLS3_k127_4763239_4 COGs COG4299 conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 407.0
TLS3_k127_4763239_5 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 340.0
TLS3_k127_4763239_6 Sigma-70 region 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000005153 250.0
TLS3_k127_4763239_7 sequence-specific DNA binding - - - 0.0000000000194 70.0
TLS3_k127_4763239_8 IrrE N-terminal-like domain - - - 0.000001187 58.0
TLS3_k127_4763239_9 Putative zinc ribbon domain - - - 0.0002089 49.0
TLS3_k127_4786372_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 9e-275 853.0
TLS3_k127_4786372_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 377.0
TLS3_k127_4786372_2 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 345.0
TLS3_k127_4786372_3 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 293.0
TLS3_k127_4786372_4 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000002059 251.0
TLS3_k127_4786372_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000371 154.0
TLS3_k127_4805584_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 512.0
TLS3_k127_4805584_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 484.0
TLS3_k127_4805584_2 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 388.0
TLS3_k127_4805584_3 7TM receptor with intracellular HD hydrolase K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 338.0
TLS3_k127_4805584_4 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000175 285.0
TLS3_k127_4805584_5 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000001135 254.0
TLS3_k127_4805584_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000004994 188.0
TLS3_k127_4805584_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000005064 183.0
TLS3_k127_4805584_8 Peptidase family M50 K06402 - - 0.000000000000000000000000000000000000005596 153.0
TLS3_k127_4853059_0 Erythromycin esterase - - - 1.433e-194 617.0
TLS3_k127_4853059_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 297.0
TLS3_k127_4853059_2 PFAM Phosphoribosyl transferase domain K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005137 269.0
TLS3_k127_4853059_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000007297 166.0
TLS3_k127_4853059_4 Psort location Cytoplasmic, score - - - 0.0000000000001393 75.0
TLS3_k127_4853059_5 Transcriptional regulator, AbiEi antitoxin - - - 0.00007774 45.0
TLS3_k127_4853059_6 Family of unknown function (DUF5335) - - - 0.000119 49.0
TLS3_k127_4880_0 Elongation factor G, domain IV K02355 - - 2.19e-226 721.0
TLS3_k127_4880_1 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003251 284.0
TLS3_k127_4880_2 Serine aminopeptidase, S33 K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002687 282.0
TLS3_k127_4880_3 - - - - 0.0000000000000000000000000000000000000000000000000000000002709 215.0
TLS3_k127_4880_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000005734 179.0
TLS3_k127_4880_5 - - - - 0.00000000000000000000000001006 119.0
TLS3_k127_4880_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery K07277 - - 0.0000000000000003454 91.0
TLS3_k127_4886075_0 ADP-glyceromanno-heptose 6-epimerase activity K01710,K01784,K08678,K08679 - 4.1.1.35,4.2.1.46,5.1.3.2,5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 507.0
TLS3_k127_4886075_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 387.0
TLS3_k127_4886075_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 355.0
TLS3_k127_4886075_3 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 323.0
TLS3_k127_4886075_4 Glycosyltransferase like family 2 - - - 0.000000000000000006936 95.0
TLS3_k127_4886075_5 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000008775 91.0
TLS3_k127_4886075_6 Glycosyl transferases group 1 - - - 0.000000000000005273 87.0
TLS3_k127_489677_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 550.0
TLS3_k127_489677_1 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 453.0
TLS3_k127_489677_10 - - - - 0.0000305 55.0
TLS3_k127_489677_11 - - - - 0.0000352 53.0
TLS3_k127_489677_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 429.0
TLS3_k127_489677_3 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 418.0
TLS3_k127_489677_4 ATPases associated with a variety of cellular activities K02003,K02004 GO:0008150,GO:0009405,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000000000000002117 233.0
TLS3_k127_489677_5 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000002531 221.0
TLS3_k127_489677_6 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000000000000000000009429 208.0
TLS3_k127_489677_7 NDK K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000001706 194.0
TLS3_k127_489677_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000001441 179.0
TLS3_k127_489677_9 OsmC-like protein K06889,K07397 - - 0.000000000000000000000000000000000002006 143.0
TLS3_k127_4910646_0 lyase activity - - - 1.369e-303 979.0
TLS3_k127_4910646_1 - - - - 6.228e-276 898.0
TLS3_k127_4910646_10 PFAM Integrase catalytic region K07497 - - 0.00002072 49.0
TLS3_k127_4910646_11 PFAM peptidase - - - 0.0001615 51.0
TLS3_k127_4910646_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 590.0
TLS3_k127_4910646_4 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000001272 214.0
TLS3_k127_4910646_5 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000001097 218.0
TLS3_k127_4910646_6 SIR2-like domain - - - 0.000000000000000000000000000000000000000000000000001632 192.0
TLS3_k127_4910646_7 Alcohol dehydrogenase GroES-associated - - - 0.00000000000000000000000000000000000000000000006752 171.0
TLS3_k127_4910646_8 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000885 148.0
TLS3_k127_4910646_9 S1/P1 Nuclease - - - 0.000000000000000000000008311 109.0
TLS3_k127_4912938_0 Belongs to the carbamoyltransferase HypF family K04656 - - 5.291e-252 798.0
TLS3_k127_4912938_1 FtsX-like permease family - - - 3.318e-206 672.0
TLS3_k127_4912938_10 Redoxin K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000009429 53.0
TLS3_k127_4912938_2 hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 575.0
TLS3_k127_4912938_3 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 446.0
TLS3_k127_4912938_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 422.0
TLS3_k127_4912938_5 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 361.0
TLS3_k127_4912938_6 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000004007 236.0
TLS3_k127_4912938_7 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000002703 125.0
TLS3_k127_4912938_8 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.00000000000000000000005593 100.0
TLS3_k127_4912938_9 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000005302 87.0
TLS3_k127_492476_1 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000000000000000000000000000000005574 193.0
TLS3_k127_492476_2 Transcriptional regulator K07727 - - 0.0000000001172 68.0
TLS3_k127_5011262_0 Flavin containing amine oxidoreductase - - - 1.122e-292 904.0
TLS3_k127_5011262_1 TIGRFAM phytoene desaturase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004509 556.0
TLS3_k127_5011262_2 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 463.0
TLS3_k127_5011262_3 PFAM Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 458.0
TLS3_k127_5011262_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 445.0
TLS3_k127_5011262_5 FGGY family of carbohydrate kinases, C-terminal domain K00851 - 2.7.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008467 384.0
TLS3_k127_5012948_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 8.786e-290 910.0
TLS3_k127_5012948_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 6.785e-235 736.0
TLS3_k127_5012948_10 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 456.0
TLS3_k127_5012948_11 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 465.0
TLS3_k127_5012948_12 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 443.0
TLS3_k127_5012948_13 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004745 421.0
TLS3_k127_5012948_14 virion core protein (lumpy skin disease virus) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 398.0
TLS3_k127_5012948_15 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 380.0
TLS3_k127_5012948_16 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 376.0
TLS3_k127_5012948_17 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 361.0
TLS3_k127_5012948_18 Extradiol ring-cleavage dioxygenase, class III K06990,K09141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 355.0
TLS3_k127_5012948_19 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 351.0
TLS3_k127_5012948_2 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 8.366e-211 672.0
TLS3_k127_5012948_20 tRNA 3'-trailer cleavage - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 342.0
TLS3_k127_5012948_21 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 325.0
TLS3_k127_5012948_22 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 323.0
TLS3_k127_5012948_23 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005705 312.0
TLS3_k127_5012948_24 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 318.0
TLS3_k127_5012948_25 Sporulation initiation inhibitor K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 302.0
TLS3_k127_5012948_26 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007991 301.0
TLS3_k127_5012948_27 site-specific DNA-methyltransferase (adenine-specific) activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 292.0
TLS3_k127_5012948_28 Enoyl-CoA hydratase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 286.0
TLS3_k127_5012948_29 Oxidoreductase, molybdopterin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003493 282.0
TLS3_k127_5012948_3 peptidase - - - 3.297e-201 649.0
TLS3_k127_5012948_30 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002348 259.0
TLS3_k127_5012948_31 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001026 244.0
TLS3_k127_5012948_32 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000008681 236.0
TLS3_k127_5012948_33 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000002352 243.0
TLS3_k127_5012948_34 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000002097 224.0
TLS3_k127_5012948_35 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000002537 214.0
TLS3_k127_5012948_36 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000663 193.0
TLS3_k127_5012948_37 - - - - 0.00000000000000000000000000000000000000000000004664 179.0
TLS3_k127_5012948_38 DSBA-like thioredoxin domain K21990 - - 0.0000000000000000000000000000000001053 143.0
TLS3_k127_5012948_39 VanZ like family - - - 0.0000000000000000000000000001054 121.0
TLS3_k127_5012948_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000572 620.0
TLS3_k127_5012948_40 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000003777 120.0
TLS3_k127_5012948_41 Jag_N K06346 - - 0.000000000000000000000000003097 116.0
TLS3_k127_5012948_42 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000005867 110.0
TLS3_k127_5012948_43 O COG0501 Zn-dependent protease with chaperone function - - - 0.00000000000000000000000002286 127.0
TLS3_k127_5012948_44 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000001366 102.0
TLS3_k127_5012948_45 Domain of unknown function (DUF4870) - - - 0.0000000000000000000009599 100.0
TLS3_k127_5012948_46 Thioesterase superfamily K07107 - - 0.00000000000000000000114 100.0
TLS3_k127_5012948_47 transcriptional - - - 0.00000000000000000000176 99.0
TLS3_k127_5012948_48 Carboxypeptidase regulatory-like domain - - - 0.00000000000009916 85.0
TLS3_k127_5012948_49 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000008059 70.0
TLS3_k127_5012948_5 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 595.0
TLS3_k127_5012948_50 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000001032 64.0
TLS3_k127_5012948_51 Vitamin K epoxide reductase - - - 0.00000004619 60.0
TLS3_k127_5012948_53 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000006732 54.0
TLS3_k127_5012948_54 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00003667 53.0
TLS3_k127_5012948_6 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 589.0
TLS3_k127_5012948_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 608.0
TLS3_k127_5012948_8 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 540.0
TLS3_k127_5012948_9 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 491.0
TLS3_k127_5191639_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 569.0
TLS3_k127_5191639_1 argininosuccinate lyase K01755,K14681 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005414 501.0
TLS3_k127_5191639_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 349.0
TLS3_k127_5191639_3 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 330.0
TLS3_k127_5191639_4 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007007 287.0
TLS3_k127_5191639_5 Mo-molybdopterin cofactor biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006589 267.0
TLS3_k127_5191639_6 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000002771 260.0
TLS3_k127_5191639_7 Pfam Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000004836 207.0
TLS3_k127_5191639_8 - - - - 0.000000000000000000000000002737 120.0
TLS3_k127_5191639_9 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000002083 96.0
TLS3_k127_5237355_0 peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 534.0
TLS3_k127_5237355_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 300.0
TLS3_k127_5237355_2 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000007484 177.0
TLS3_k127_5237355_3 Diacylglycerol kinase - - - 0.0000000000000000000000000000000000000002314 162.0
TLS3_k127_5237766_0 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.0 1252.0
TLS3_k127_5237766_1 PFAM NHL repeat - - - 1.175e-203 654.0
TLS3_k127_5237766_10 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000006102 243.0
TLS3_k127_5237766_11 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000001024 200.0
TLS3_k127_5237766_12 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000004665 157.0
TLS3_k127_5237766_13 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000007026 136.0
TLS3_k127_5237766_14 Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000000000005274 140.0
TLS3_k127_5237766_15 Phosphoglycerate mutase family - - - 0.000000000000000000001859 103.0
TLS3_k127_5237766_16 Two component signalling adaptor domain K03408 - - 0.0000002642 58.0
TLS3_k127_5237766_2 PFAM Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 608.0
TLS3_k127_5237766_3 PFAM D12 class N6 adenine-specific DNA methyltransferase K07318 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 518.0
TLS3_k127_5237766_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 511.0
TLS3_k127_5237766_5 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008106 507.0
TLS3_k127_5237766_6 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 417.0
TLS3_k127_5237766_7 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 353.0
TLS3_k127_5237766_8 Ferritin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 289.0
TLS3_k127_5237766_9 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000002363 267.0
TLS3_k127_5245061_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 547.0
TLS3_k127_5245061_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 341.0
TLS3_k127_5245061_2 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.000000000000000000000000000000000000000000000000000000000000005791 228.0
TLS3_k127_5245061_3 membrane - - - 0.00000000000000000000000000000000002252 141.0
TLS3_k127_5245061_4 - - - - 0.0000000000000000000003775 98.0
TLS3_k127_5246557_0 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 494.0
TLS3_k127_5246557_1 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007913 451.0
TLS3_k127_5246557_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005277 332.0
TLS3_k127_5246557_3 Parallel beta-helix repeats K12287 - - 0.00000000000000000000000000000000000000000000000000229 210.0
TLS3_k127_5246557_4 Belongs to the 'phage' integrase family - - - 0.0000000000000000000001871 106.0
TLS3_k127_5268207_0 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000000000000000000000000000000000000000000007654 165.0
TLS3_k127_5268207_1 guanyl-nucleotide exchange factor activity K20276 - - 0.00000000000000000000000000000000000000000001991 180.0
TLS3_k127_5268207_2 SpoVT / AbrB like domain - - - 0.00000000000000000000000117 104.0
TLS3_k127_5268207_3 - - - - 0.0008146 43.0
TLS3_k127_5271164_0 Asparagine synthase - - - 1.606e-235 745.0
TLS3_k127_5271164_1 Mur ligase middle domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 465.0
TLS3_k127_5271164_10 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000001534 174.0
TLS3_k127_5271164_11 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000001008 130.0
TLS3_k127_5271164_12 Protein of unknown function (DUF1232) - - - 0.00000000000000000000000007473 112.0
TLS3_k127_5271164_13 Sensory domain in DIguanylate Cyclases and Two-component system - - - 0.000000000000000007335 91.0
TLS3_k127_5271164_14 - - - - 0.000000000000006033 85.0
TLS3_k127_5271164_15 domain protein K20276 - - 0.00000000001613 78.0
TLS3_k127_5271164_17 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00001196 59.0
TLS3_k127_5271164_18 von Willebrand factor, type A - - - 0.0001038 54.0
TLS3_k127_5271164_19 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0003197 48.0
TLS3_k127_5271164_2 PFAM Phosphate acetyl butaryl transferase K00625 GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 353.0
TLS3_k127_5271164_3 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K20444 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 341.0
TLS3_k127_5271164_4 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 314.0
TLS3_k127_5271164_5 Response receiver-modulated cyclic diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 317.0
TLS3_k127_5271164_6 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001726 276.0
TLS3_k127_5271164_7 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000003516 211.0
TLS3_k127_5271164_8 PFAM Bacterial transferase hexapeptide (three repeats) K00661 - 2.3.1.79 0.000000000000000000000000000000000000000000000000004903 188.0
TLS3_k127_5271164_9 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000001372 179.0
TLS3_k127_5277513_0 Belongs to the peptidase S8 family K08651,K14645 - 3.4.21.66 0.0 1547.0
TLS3_k127_5277513_1 choline dehydrogenase activity K00108 - 1.1.99.1 1.964e-254 799.0
TLS3_k127_5277513_2 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 496.0
TLS3_k127_5277513_3 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 323.0
TLS3_k127_5277513_4 Cytochrome c - - - 0.0000000000000018 76.0
TLS3_k127_5281936_0 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 598.0
TLS3_k127_5281936_1 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 575.0
TLS3_k127_5281936_10 PFAM Chorismate mutase, type II - - - 0.0000000000000859 74.0
TLS3_k127_5281936_2 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 453.0
TLS3_k127_5281936_3 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 406.0
TLS3_k127_5281936_4 Protein of unknown function (DUF4199) - - - 0.00000000000000000000000000000000000000000000000000000001944 202.0
TLS3_k127_5281936_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000002004 174.0
TLS3_k127_5281936_6 arogenate dehydratase activity K05359,K20102 GO:0003674,GO:0003824,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009637,GO:0009642,GO:0009645,GO:0009987,GO:0010244,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047769,GO:0050896,GO:0071704,GO:0080167,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51,4.2.1.91 0.00000000000000000000000000000000000002857 150.0
TLS3_k127_5281936_7 Thiol-disulfide oxidoreductase DCC - - - 0.00000000000000000000000000000000008208 137.0
TLS3_k127_5281936_8 GYD domain - - - 0.0000000000000000000000000356 110.0
TLS3_k127_5299801_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 503.0
TLS3_k127_5299801_1 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008375 269.0
TLS3_k127_5299801_2 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000001678 258.0
TLS3_k127_5299801_3 YjbR - - - 0.000000000000000000000000000000000000000000009854 167.0
TLS3_k127_5299801_4 transcriptional regulator - - - 0.00000000000000000000000000000000000000000001028 170.0
TLS3_k127_5299801_5 CHAT domain - - - 0.000000000000000000000000000005611 139.0
TLS3_k127_5299801_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000003711 76.0
TLS3_k127_5299801_7 tetratricopeptide repeat - - - 0.0000000002162 73.0
TLS3_k127_5299801_8 - - - - 0.0000178 55.0
TLS3_k127_5322535_0 cellulose binding - - - 1.952e-294 936.0
TLS3_k127_5322535_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.11e-233 731.0
TLS3_k127_5322535_2 SAM-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 383.0
TLS3_k127_5322535_3 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 310.0
TLS3_k127_5322535_4 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000001652 244.0
TLS3_k127_5322535_5 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000133 209.0
TLS3_k127_5322535_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000004849 121.0
TLS3_k127_5348763_0 Alpha-2-Macroglobulin K06894 - - 1.572e-300 980.0
TLS3_k127_5348763_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000858 293.0
TLS3_k127_5348763_10 - - - - 0.000000000000000001862 90.0
TLS3_k127_5348763_11 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000001659 74.0
TLS3_k127_5348763_12 - - - - 0.000000000001305 70.0
TLS3_k127_5348763_13 Helix-turn-helix - - - 0.00000001238 63.0
TLS3_k127_5348763_14 Helix-turn-helix XRE-family like proteins - - - 0.0006148 46.0
TLS3_k127_5348763_2 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008279 246.0
TLS3_k127_5348763_3 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000007141 247.0
TLS3_k127_5348763_4 - - - - 0.00000000000000000000000000000000000000000000000000000000001946 228.0
TLS3_k127_5348763_5 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000008988 229.0
TLS3_k127_5348763_6 Protein of unknown function (DUF1175) K09934 - - 0.0000000000000000000000000000000000000000000000000001753 196.0
TLS3_k127_5348763_7 PIN domain K07062 - - 0.00000000000000000000000000000000000000008299 155.0
TLS3_k127_5348763_8 - - - - 0.00000000000000000000000001206 111.0
TLS3_k127_5348763_9 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 0.000000000000000000121 105.0
TLS3_k127_5378052_0 diphthine synthase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 583.0
TLS3_k127_5378052_1 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 556.0
TLS3_k127_5378052_10 phosphoserine phosphatase activity K07315,K16928 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000002151 225.0
TLS3_k127_5378052_11 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000006417 207.0
TLS3_k127_5378052_12 protein conserved in bacteria K04750 - - 0.000000000000000000000000000000000000000000000000000000001908 203.0
TLS3_k127_5378052_13 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000008557 184.0
TLS3_k127_5378052_14 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000002909 169.0
TLS3_k127_5378052_15 Protein of unknown function (DUF1428) K01077 - 3.1.3.1 0.000000000000000000000000000000000000000002492 158.0
TLS3_k127_5378052_16 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000001064 149.0
TLS3_k127_5378052_17 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000001608 141.0
TLS3_k127_5378052_19 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000007217 141.0
TLS3_k127_5378052_2 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 468.0
TLS3_k127_5378052_20 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000001171 97.0
TLS3_k127_5378052_22 - - - - 0.0000000000003178 79.0
TLS3_k127_5378052_23 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000002657 74.0
TLS3_k127_5378052_24 AhpC/TSA family - - - 0.0000002911 56.0
TLS3_k127_5378052_25 Putative zinc-finger - - - 0.0006137 50.0
TLS3_k127_5378052_3 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 374.0
TLS3_k127_5378052_4 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007109 367.0
TLS3_k127_5378052_5 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 342.0
TLS3_k127_5378052_6 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 315.0
TLS3_k127_5378052_7 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 316.0
TLS3_k127_5378052_8 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003707 274.0
TLS3_k127_5378052_9 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000618 258.0
TLS3_k127_5380923_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 319.0
TLS3_k127_5380923_1 DNA-directed DNA polymerase activity K02347,K03581,K04477 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000005888 267.0
TLS3_k127_5380923_2 PFAM Uncharacterised protein family UPF0027 K14415 - 6.5.1.3 0.0000000000000000000002483 98.0
TLS3_k127_5380923_3 - - - - 0.0000000000001004 77.0
TLS3_k127_5380923_4 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000006764 64.0
TLS3_k127_5390067_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 383.0
TLS3_k127_5390067_1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K21310 - 2.1.1.334 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 345.0
TLS3_k127_5390067_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 312.0
TLS3_k127_5390067_3 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008553 263.0
TLS3_k127_5390067_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000001067 228.0
TLS3_k127_5390067_5 - - - - 0.00000000000000000000003286 106.0
TLS3_k127_5398310_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 532.0
TLS3_k127_5398310_1 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005536 475.0
TLS3_k127_5398310_10 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000001964 196.0
TLS3_k127_5398310_11 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000000000000009194 176.0
TLS3_k127_5398310_12 LemA family K03744 - - 0.00000000000000000000000000000000000000000003352 168.0
TLS3_k127_5398310_13 nucleotidyltransferase activity - - - 0.0000000000000000000000000000000000001519 151.0
TLS3_k127_5398310_14 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000003111 143.0
TLS3_k127_5398310_15 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.0000000000000000000000003743 107.0
TLS3_k127_5398310_16 TPM domain K06872 - - 0.000000000000000000000001792 114.0
TLS3_k127_5398310_17 Ethanolamine utilisation protein EutN/carboxysome K04028 - - 0.000000008059 60.0
TLS3_k127_5398310_18 Cell division protein FtsQ K03589 - - 0.000002183 59.0
TLS3_k127_5398310_19 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.00002435 51.0
TLS3_k127_5398310_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007 403.0
TLS3_k127_5398310_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 389.0
TLS3_k127_5398310_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008364 355.0
TLS3_k127_5398310_5 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 330.0
TLS3_k127_5398310_6 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 327.0
TLS3_k127_5398310_7 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 310.0
TLS3_k127_5398310_8 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007491 290.0
TLS3_k127_5398310_9 ZIP Zinc transporter K07238,K11021,K16267 - - 0.00000000000000000000000000000000000000000000000000000000000155 219.0
TLS3_k127_5440409_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 475.0
TLS3_k127_5440409_1 phenylalanyl-tRNA synthetase (alpha subunit) K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 351.0
TLS3_k127_5440409_2 YmdB-like protein K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001316 280.0
TLS3_k127_5440409_3 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000002639 179.0
TLS3_k127_5440409_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000008417 154.0
TLS3_k127_5440409_5 Putative lumazine-binding - - - 0.000000000000000000000005982 102.0
TLS3_k127_5440409_6 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000005418 56.0
TLS3_k127_5440409_7 peptidase S9 - - - 0.00004585 53.0
TLS3_k127_5443907_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 1.999e-285 905.0
TLS3_k127_5443907_1 Vault protein inter-alpha-trypsin domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 511.0
TLS3_k127_5443907_10 Peptidase M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001179 297.0
TLS3_k127_5443907_11 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000001886 245.0
TLS3_k127_5443907_12 Photosynthesis system II assembly factor YCF48 - - - 0.0000000000000000000000000000000000000000000000000000002891 207.0
TLS3_k127_5443907_13 PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000006158 186.0
TLS3_k127_5443907_14 - - - - 0.0000000000000000000000000000000000000000000000001326 181.0
TLS3_k127_5443907_15 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000001348 161.0
TLS3_k127_5443907_16 nudix family K01515 - 3.6.1.13 0.00000000000000000000000000000000000000876 152.0
TLS3_k127_5443907_17 Protein of unknown function (DUF962) - - - 0.0000000000000000000000000000000000004496 141.0
TLS3_k127_5443907_18 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF K07402 - - 0.00000000000000000000000000000000001299 147.0
TLS3_k127_5443907_19 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000008598 142.0
TLS3_k127_5443907_2 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 473.0
TLS3_k127_5443907_20 response regulator - - - 0.0000000000000000000000000000000117 142.0
TLS3_k127_5443907_21 Zn peptidase K21686 - - 0.00000000000000000000000006103 115.0
TLS3_k127_5443907_22 Xanthine and CO dehydrogenases maturation factor XdhC CoxF K07402 - - 0.0000000000000000000000006131 107.0
TLS3_k127_5443907_23 Flavin containing amine oxidoreductase - - - 0.000000000000000000003745 106.0
TLS3_k127_5443907_24 von Willebrand factor, type A - - - 0.00000000000000000003211 105.0
TLS3_k127_5443907_25 iron ion homeostasis - - - 0.0000000000000000003992 100.0
TLS3_k127_5443907_26 PFAM regulatory protein GntR HTH K07979 - - 0.000000000000000000848 91.0
TLS3_k127_5443907_27 von Willebrand factor, type A - - - 0.00000000000000009293 92.0
TLS3_k127_5443907_28 methyltransferase - - - 0.0000000000000001719 89.0
TLS3_k127_5443907_3 Vault protein inter-alpha-trypsin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 456.0
TLS3_k127_5443907_30 CAAX protease self-immunity K07052 - - 0.000008642 57.0
TLS3_k127_5443907_31 sequence-specific DNA binding - - - 0.0003596 49.0
TLS3_k127_5443907_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 336.0
TLS3_k127_5443907_5 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 341.0
TLS3_k127_5443907_6 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 338.0
TLS3_k127_5443907_7 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 332.0
TLS3_k127_5443907_8 PFAM Mur ligase K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 303.0
TLS3_k127_5443907_9 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 302.0
TLS3_k127_5467856_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 483.0
TLS3_k127_5467856_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 411.0
TLS3_k127_5467856_10 HAD-superfamily hydrolase, subfamily IIB - - - 0.00000000000000000000000000000000000002051 156.0
TLS3_k127_5467856_11 PFAM thiamine monophosphate synthase K00788 - 2.5.1.3 0.000000000000000000000000000000000001876 145.0
TLS3_k127_5467856_12 O-antigen ligase like membrane protein - - - 0.0000000003444 72.0
TLS3_k127_5467856_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 335.0
TLS3_k127_5467856_3 Formyl transferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000006226 241.0
TLS3_k127_5467856_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000001744 238.0
TLS3_k127_5467856_5 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000003344 204.0
TLS3_k127_5467856_6 Phosphomethylpyrimidine kinase K00941,K14153 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000005286 203.0
TLS3_k127_5467856_7 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000002664 186.0
TLS3_k127_5467856_8 BON domain - - - 0.000000000000000000000000000000000000000000006332 169.0
TLS3_k127_5467856_9 RDD family - - - 0.000000000000000000000000000000000000000005355 164.0
TLS3_k127_5495119_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 8.42e-307 957.0
TLS3_k127_5495119_1 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 7.574e-209 662.0
TLS3_k127_5495119_10 peptidase M15B and M15C DD-carboxypeptidase VanY - - - 0.0000000000000000009257 98.0
TLS3_k127_5495119_11 chaperone-mediated protein folding - - - 0.000000000000000004738 91.0
TLS3_k127_5495119_12 PFAM Bacterial pre-peptidase C-terminal domain - - - 0.0000000000000000152 99.0
TLS3_k127_5495119_13 lysyltransferase activity K07027 - - 0.0000000001026 73.0
TLS3_k127_5495119_2 Acyl-CoA dehydrogenase, C-terminal domain K00248,K09478 - 1.3.8.1,1.3.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 542.0
TLS3_k127_5495119_3 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 456.0
TLS3_k127_5495119_4 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 401.0
TLS3_k127_5495119_5 Peptidase M16 inactive domain K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 318.0
TLS3_k127_5495119_6 Parallel beta-helix repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 334.0
TLS3_k127_5495119_7 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000009483 221.0
TLS3_k127_5495119_8 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000000001263 215.0
TLS3_k127_5495119_9 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000005125 183.0
TLS3_k127_5500327_0 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 1.514e-241 762.0
TLS3_k127_5500327_1 POT family K03305 - - 3.432e-227 714.0
TLS3_k127_5500327_2 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 613.0
TLS3_k127_5500327_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 431.0
TLS3_k127_5500327_4 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 344.0
TLS3_k127_5500327_5 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000002522 203.0
TLS3_k127_5500327_6 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000003604 150.0
TLS3_k127_5512048_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 362.0
TLS3_k127_5512048_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 346.0
TLS3_k127_5512048_2 Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 295.0
TLS3_k127_5512048_3 Transcriptional regulator, LysR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005438 256.0
TLS3_k127_5512048_4 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000000000000001953 221.0
TLS3_k127_5512048_5 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000001526 181.0
TLS3_k127_5512048_6 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000001268 183.0
TLS3_k127_5512048_7 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000001497 143.0
TLS3_k127_5559176_0 PFAM type II secretion system protein E K02283,K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 566.0
TLS3_k127_5559176_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 351.0
TLS3_k127_5559176_10 TadE-like protein - - - 0.000000000005182 73.0
TLS3_k127_5559176_11 TadE-like protein - - - 0.00000000000686 72.0
TLS3_k127_5559176_12 - - - - 0.000000288 61.0
TLS3_k127_5559176_13 to Saccharomyces cerevisiae CTR9 (YOL145C) K15176 GO:0000082,GO:0000083,GO:0000278,GO:0000414,GO:0000416,GO:0000428,GO:0000785,GO:0000988,GO:0000989,GO:0000993,GO:0001015,GO:0001076,GO:0001098,GO:0001099,GO:0001932,GO:0001934,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006282,GO:0006351,GO:0006353,GO:0006354,GO:0006355,GO:0006356,GO:0006357,GO:0006360,GO:0006362,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0007049,GO:0008023,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009302,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010628,GO:0010638,GO:0016070,GO:0016071,GO:0016074,GO:0016591,GO:0016593,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019899,GO:0022402,GO:0030880,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031123,GO:0031124,GO:0031126,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031396,GO:0031399,GO:0031401,GO:0031935,GO:0031938,GO:0031974,GO:0031981,GO:0032268,GO:0032270,GO:0032774,GO:0032784,GO:0032786,GO:0032968,GO:0032991,GO:0033043,GO:0033044,GO:0033182,GO:0034243,GO:0034470,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0035327,GO:0042325,GO:0042327,GO:0043144,GO:0043170,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043628,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0044877,GO:0045142,GO:0045309,GO:0045893,GO:0045935,GO:0045937,GO:0045943,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050815,GO:0051052,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051219,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051569,GO:0055029,GO:0060255,GO:0060260,GO:0060968,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090262,GO:0090304,GO:0097159,GO:0097659,GO:0098781,GO:0099122,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901407,GO:1901409,GO:1901576,GO:1902275,GO:1902494,GO:1902680,GO:1903047,GO:1903320,GO:1903506,GO:1903508,GO:1905269,GO:1990234,GO:1990269,GO:2000112,GO:2000142,GO:2000819,GO:2001020,GO:2001141,GO:2001163,GO:2001165,GO:2001166,GO:2001173,GO:2001207,GO:2001209,GO:2001252,GO:2001253,GO:2001255 - 0.00005191 55.0
TLS3_k127_5559176_2 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 332.0
TLS3_k127_5559176_3 Type II secretion system K12510 - - 0.00000000000000000000000000000000000000000000000000000000007019 216.0
TLS3_k127_5559176_4 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000002494 195.0
TLS3_k127_5559176_5 PFAM type II secretion system K12511 - - 0.000000000000000000000000000000000000000000000001592 185.0
TLS3_k127_5559176_6 response regulator K07685 - - 0.00000000000000000000000000000000000000000000001791 179.0
TLS3_k127_5559176_7 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000000000000000000000000007014 148.0
TLS3_k127_5559176_8 von Willebrand factor, type A - - - 0.0000000000000000000000003382 118.0
TLS3_k127_5571304_0 Carbamoyltransferase C-terminus K00612 - - 3.666e-195 628.0
TLS3_k127_5571304_1 PFAM NAD-dependent epimerase dehydratase K08678 - 4.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 497.0
TLS3_k127_5571304_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000007393 250.0
TLS3_k127_5571304_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000001405 188.0
TLS3_k127_5571304_12 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000009058 178.0
TLS3_k127_5571304_13 O-Antigen ligase K02847 - - 0.00000000000000000000000000000001506 142.0
TLS3_k127_5571304_14 Glycoprotease family K01409,K14742 - 2.3.1.234 0.0000000000000000000000000004727 122.0
TLS3_k127_5571304_15 FR47-like protein K03789 - 2.3.1.128 0.00000000000000000001532 98.0
TLS3_k127_5571304_16 Protein of unknown function (DUF465) - - - 0.0000006437 54.0
TLS3_k127_5571304_17 Formyl transferase, C-terminal domain K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0003797 46.0
TLS3_k127_5571304_18 PFAM TPR repeat-containing protein - - - 0.0004955 52.0
TLS3_k127_5571304_2 asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 464.0
TLS3_k127_5571304_3 GTP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 422.0
TLS3_k127_5571304_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 408.0
TLS3_k127_5571304_5 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008902 394.0
TLS3_k127_5571304_6 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 355.0
TLS3_k127_5571304_7 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002358 284.0
TLS3_k127_5571304_8 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002578 244.0
TLS3_k127_5571304_9 Glycosyl transferase family 4 K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000293 251.0
TLS3_k127_5584976_0 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007912 559.0
TLS3_k127_5584976_1 GHMP kinases C terminal K07031 - 2.7.1.168 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 295.0
TLS3_k127_5584976_2 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001836 277.0
TLS3_k127_5584976_3 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000001119 213.0
TLS3_k127_5584976_4 Phosphoribosyl transferase domain K00762 - 2.4.2.10 0.000000000000000000000000000000000000000009126 161.0
TLS3_k127_5584976_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000000002296 113.0
TLS3_k127_5584976_6 Belongs to the Nudix hydrolase family - - - 0.00000000000000000006446 95.0
TLS3_k127_5584976_7 Membrane - GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0051301,GO:0071944 - 0.00000000000000004247 90.0
TLS3_k127_5596785_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 5.346e-232 727.0
TLS3_k127_5596785_1 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007837 450.0
TLS3_k127_5596785_2 Protein tyrosine kinase K08884 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000804 252.0
TLS3_k127_5596785_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000001179 203.0
TLS3_k127_5596785_4 RNA recognition motif - - - 0.00000000000000000000000000000000002324 139.0
TLS3_k127_5597369_0 Cys/Met metabolism PLP-dependent enzyme K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009953 489.0
TLS3_k127_5597369_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008907 490.0
TLS3_k127_5597369_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000004933 233.0
TLS3_k127_5597369_3 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000000000000004443 119.0
TLS3_k127_5597369_4 regulatory protein, MerR - - - 0.00000000000000000000000135 110.0
TLS3_k127_5597369_5 Addiction module component, TIGR02574 family - - - 0.00000000000213 69.0
TLS3_k127_5597369_6 positive regulation of growth - - - 0.0007961 44.0
TLS3_k127_5608459_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 520.0
TLS3_k127_5608459_1 shikimate 3-dehydrogenase (NADP+) activity K00014,K13832 GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005805 325.0
TLS3_k127_5608459_2 Low molecular weight phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009725 294.0
TLS3_k127_5608459_3 transferase activity, transferring glycosyl groups K00713,K06338 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001045 281.0
TLS3_k127_5608459_4 pathogenesis - - - 0.0000000000000000000000000000000000000000000000001272 188.0
TLS3_k127_5608459_5 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000006752 190.0
TLS3_k127_5608459_6 translation initiation inhibitor, yjgF family K09022 GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019239,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046360,GO:0046361,GO:0046394,GO:0046459,GO:0051790,GO:0071704,GO:0072330,GO:1901576 3.5.99.10 0.00000000000000000000000001434 114.0
TLS3_k127_5673937_0 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 616.0
TLS3_k127_5673937_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 433.0
TLS3_k127_5673937_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K21310 - 2.1.1.334 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 340.0
TLS3_k127_5673937_3 COG0076 Glutamate decarboxylase and related PLP-dependent proteins - - - 0.0000000000000000002335 97.0
TLS3_k127_5695348_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 514.0
TLS3_k127_5695348_1 COG3621 Patatin K06900 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 406.0
TLS3_k127_5695348_2 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 310.0
TLS3_k127_5695348_3 Chlorophyllase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 293.0
TLS3_k127_5695348_5 Copper/zinc superoxide dismutase (SODC) K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000000009115 179.0
TLS3_k127_5695348_6 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000001523 143.0
TLS3_k127_5695348_7 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000164 116.0
TLS3_k127_5695348_8 arsR family - - - 0.0000000000000000001117 92.0
TLS3_k127_5701438_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 4.727e-252 795.0
TLS3_k127_5701438_1 Sodium:solute symporter family - - - 1.984e-214 682.0
TLS3_k127_5701438_10 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 303.0
TLS3_k127_5701438_11 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003056 294.0
TLS3_k127_5701438_12 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000006949 237.0
TLS3_k127_5701438_13 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000008159 182.0
TLS3_k127_5701438_14 Bacterial regulatory proteins, gntR family - - - 0.0000000711 58.0
TLS3_k127_5701438_15 energy transducer activity K03832 - - 0.0007098 51.0
TLS3_k127_5701438_16 SMART Rhodanese domain protein - - - 0.0009726 42.0
TLS3_k127_5701438_2 Alpha/beta hydrolase family - - - 4.797e-204 657.0
TLS3_k127_5701438_3 Male sterility protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009108 589.0
TLS3_k127_5701438_4 Domain of unknown function (DUF3536) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 507.0
TLS3_k127_5701438_5 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 493.0
TLS3_k127_5701438_6 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008084 492.0
TLS3_k127_5701438_7 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 456.0
TLS3_k127_5701438_8 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 423.0
TLS3_k127_5701438_9 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 309.0
TLS3_k127_5840757_0 - - - - 0.00000000000000000000000000000000000000000000000000001872 198.0
TLS3_k127_5840757_1 Methyltransferase domain - - - 0.000000000000000000000000000000000001922 148.0
TLS3_k127_5840757_2 Psort location CytoplasmicMembrane, score - - - 0.00000000000000001893 95.0
TLS3_k127_5840757_3 peptidyl-tyrosine sulfation - - - 0.000000002179 68.0
TLS3_k127_5868848_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372,K02567 - - 3.559e-289 905.0
TLS3_k127_5868848_1 Voltage-dependent anion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 404.0
TLS3_k127_5868848_2 nitrite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 320.0
TLS3_k127_5868848_3 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006036 276.0
TLS3_k127_5868848_4 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007029 234.0
TLS3_k127_5868848_5 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.0000000000000000000000000000006105 132.0
TLS3_k127_5868848_6 Flavocytochrome c sulphide dehydrogenase, flavin-binding K05301,K17218 - 1.8.2.1,1.8.5.4 0.00000000000000000000000000245 112.0
TLS3_k127_5868848_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000006392 104.0
TLS3_k127_5871578_0 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000658 289.0
TLS3_k127_5871578_1 SLBB domain K01991 - - 0.0000000000000000000000002574 116.0
TLS3_k127_593122_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169,K03737 - 1.2.7.1 0.0 1686.0
TLS3_k127_593122_1 efflux transmembrane transporter activity - - - 1.957e-241 770.0
TLS3_k127_593122_2 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 452.0
TLS3_k127_593122_3 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 337.0
TLS3_k127_593122_4 Cupin domain - - - 0.000000000000000000000000000000000000000000000000001241 186.0
TLS3_k127_593122_6 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.00000000000000000000000003124 116.0
TLS3_k127_60007_0 PFAM CBS domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 482.0
TLS3_k127_60007_1 Zeta toxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001317 262.0
TLS3_k127_60007_2 PFAM SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000003104 216.0
TLS3_k127_60007_3 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01739 - 2.5.1.48 0.000000000000000000000000000000002361 132.0
TLS3_k127_60007_4 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000223 90.0
TLS3_k127_6001773_0 Flavin-binding monooxygenase-like - - - 1.093e-225 707.0
TLS3_k127_6001773_1 Amidohydrolase family K06015 - 3.5.1.81 4.883e-213 678.0
TLS3_k127_6001773_10 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000007614 156.0
TLS3_k127_6001773_11 - - - - 0.0000000000000000000000000000002482 128.0
TLS3_k127_6001773_2 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 563.0
TLS3_k127_6001773_3 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 394.0
TLS3_k127_6001773_4 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 295.0
TLS3_k127_6001773_5 aspartate racemase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007419 247.0
TLS3_k127_6001773_6 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000001824 247.0
TLS3_k127_6001773_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000006917 220.0
TLS3_k127_6001773_8 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000005627 199.0
TLS3_k127_6001773_9 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000002939 158.0
TLS3_k127_600541_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.187e-270 856.0
TLS3_k127_600541_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 616.0
TLS3_k127_600541_2 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000000000000000000002857 244.0
TLS3_k127_600541_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000006411 127.0
TLS3_k127_600541_4 4Fe-4S single cluster domain of Ferredoxin I - - - 0.000000000000000000000000003668 112.0
TLS3_k127_600541_5 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000107 121.0
TLS3_k127_600541_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000001715 100.0
TLS3_k127_600541_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.0000000000000000002893 91.0
TLS3_k127_600541_8 Parallel beta-helix repeats - - - 0.000000000605 72.0
TLS3_k127_6034075_0 Phosphopantetheine attachment site - - - 1.327e-256 821.0
TLS3_k127_6034075_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 5.893e-255 794.0
TLS3_k127_6034075_10 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 404.0
TLS3_k127_6034075_11 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 371.0
TLS3_k127_6034075_12 Ornithine cyclodeaminase/mu-crystallin family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 338.0
TLS3_k127_6034075_13 PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 333.0
TLS3_k127_6034075_14 Thioesterase domain K01071 - 3.1.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006084 277.0
TLS3_k127_6034075_15 Ion transport 2 domain protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003715 261.0
TLS3_k127_6034075_16 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000303 251.0
TLS3_k127_6034075_17 Phosphomethylpyrimidine kinase K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000001445 244.0
TLS3_k127_6034075_18 D,d-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000000000000008612 225.0
TLS3_k127_6034075_19 lipopolysaccharide heptosyltransferase K02841,K02843 - - 0.0000000000000000000000000000000000000000000000000000001954 209.0
TLS3_k127_6034075_2 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 2.273e-211 664.0
TLS3_k127_6034075_20 PFAM Nickel cobalt transporter, high-affinity - - - 0.00000000000000000000000000000000000000000000000001168 188.0
TLS3_k127_6034075_21 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000004667 183.0
TLS3_k127_6034075_22 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000003762 180.0
TLS3_k127_6034075_23 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000009587 157.0
TLS3_k127_6034075_24 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000001012 149.0
TLS3_k127_6034075_25 helix_turn_helix, arabinose operon control protein K07506 - - 0.00000000000000000000000000591 121.0
TLS3_k127_6034075_26 Polysaccharide biosynthesis protein K12454 - 5.1.3.10 0.0000000000000000000000001613 116.0
TLS3_k127_6034075_27 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.0000000000000000000000003463 109.0
TLS3_k127_6034075_28 KOW (Kyprides, Ouzounis, Woese) motif. K05785 - - 0.000000000000000000000003201 109.0
TLS3_k127_6034075_29 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.00000000000000000000006477 100.0
TLS3_k127_6034075_3 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 614.0
TLS3_k127_6034075_30 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000005878 82.0
TLS3_k127_6034075_31 Protein of unknown function (DUF3108) - - - 0.00000000001515 74.0
TLS3_k127_6034075_32 PBS lyase HEAT-like repeat - - - 0.0001774 52.0
TLS3_k127_6034075_4 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 555.0
TLS3_k127_6034075_5 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 526.0
TLS3_k127_6034075_6 sequence-specific DNA binding K01697,K01738 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 531.0
TLS3_k127_6034075_7 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 503.0
TLS3_k127_6034075_8 C-terminal, D2-small domain, of ClpB protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 457.0
TLS3_k127_6034075_9 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 445.0
TLS3_k127_6046375_0 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 560.0
TLS3_k127_6046375_1 Peptidase M56 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 481.0
TLS3_k127_6046375_2 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000006269 158.0
TLS3_k127_6046375_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000001587 158.0
TLS3_k127_6046375_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03116,K03117 - - 0.000000000007864 73.0
TLS3_k127_6065835_0 Carboxypeptidase regulatory-like domain - - - 0.0 1035.0
TLS3_k127_6065835_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 6.316e-230 722.0
TLS3_k127_6065835_10 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000004141 234.0
TLS3_k127_6065835_11 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000005923 243.0
TLS3_k127_6065835_12 Thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000004603 226.0
TLS3_k127_6065835_13 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000008068 243.0
TLS3_k127_6065835_14 PFAM regulatory protein TetR K13770 - - 0.00000000000000000000000000000000000000000000000009166 184.0
TLS3_k127_6065835_15 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000006869 162.0
TLS3_k127_6065835_16 Putative lumazine-binding - - - 0.000000000000000000000000000000000000000007817 158.0
TLS3_k127_6065835_17 - - - - 0.0000000000000000000000000000000000005645 160.0
TLS3_k127_6065835_18 PFAM oxidoreductase FAD NAD(P)-binding domain protein - - - 0.0000000000000000000000000000008112 131.0
TLS3_k127_6065835_19 - - - - 0.00000000000000000000000000005574 121.0
TLS3_k127_6065835_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 583.0
TLS3_k127_6065835_20 RNA recognition motif - - - 0.0000000000000000000000000002494 120.0
TLS3_k127_6065835_21 Diguanylate cyclase - - - 0.00000000000000000000000001105 127.0
TLS3_k127_6065835_22 Amidohydrolase family - - - 0.000000000000000001649 90.0
TLS3_k127_6065835_23 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions - GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 - 0.000000000000000009664 91.0
TLS3_k127_6065835_24 Mo-molybdopterin cofactor biosynthetic process - - - 0.00000000000000002255 88.0
TLS3_k127_6065835_25 Protein of unknown function (DUF3142) - - - 0.000000000007998 78.0
TLS3_k127_6065835_26 TIGRFAM TonB K03832 - - 0.00000000003881 74.0
TLS3_k127_6065835_27 Carboxypeptidase regulatory-like domain - - - 0.0000000198 68.0
TLS3_k127_6065835_28 aminopeptidase activity - - - 0.00000002123 67.0
TLS3_k127_6065835_29 Clostripain family - - - 0.00000002945 66.0
TLS3_k127_6065835_3 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005672 512.0
TLS3_k127_6065835_31 - - - - 0.00000228 51.0
TLS3_k127_6065835_32 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00008387 56.0
TLS3_k127_6065835_4 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004197 461.0
TLS3_k127_6065835_5 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 380.0
TLS3_k127_6065835_6 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 372.0
TLS3_k127_6065835_7 CRP FNR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 312.0
TLS3_k127_6065835_8 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004962 293.0
TLS3_k127_6065835_9 Haemolysin-III related K11068 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007774 261.0
TLS3_k127_6109228_0 Glycosyltransferase 36 associated - - - 0.0 2720.0
TLS3_k127_6109228_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 5.982e-287 897.0
TLS3_k127_6109228_10 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003619 272.0
TLS3_k127_6109228_11 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000025 253.0
TLS3_k127_6109228_12 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000005233 243.0
TLS3_k127_6109228_13 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000005793 230.0
TLS3_k127_6109228_14 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000000000000000000000000000000000002817 253.0
TLS3_k127_6109228_15 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000005773 222.0
TLS3_k127_6109228_16 Sulfate ABC transporter substrate-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000006132 229.0
TLS3_k127_6109228_17 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000001194 210.0
TLS3_k127_6109228_18 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000001478 199.0
TLS3_k127_6109228_19 - - - - 0.00000000000000000000000000000000000000000000000000005136 200.0
TLS3_k127_6109228_2 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 1.586e-215 674.0
TLS3_k127_6109228_20 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000007413 185.0
TLS3_k127_6109228_21 TIGRFAM sulfate ABC transporter, inner membrane subunit CysT K02046 - - 0.00000000000000000000000000000000000000000000000009585 188.0
TLS3_k127_6109228_22 'dna polymerase iii K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000003094 186.0
TLS3_k127_6109228_23 Putative restriction endonuclease - - - 0.000000000000000000000000000000000002412 144.0
TLS3_k127_6109228_24 MobA-like NTP transferase domain K03752 - 2.7.7.77 0.0000000000000000000000000005284 121.0
TLS3_k127_6109228_25 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000285 105.0
TLS3_k127_6109228_26 Belongs to the UPF0235 family K09131 - - 0.000000000000000003047 87.0
TLS3_k127_6109228_27 Tetratricopeptide repeat - - - 0.00000000008065 72.0
TLS3_k127_6109228_29 YGGT family K02221 - - 0.000000006188 65.0
TLS3_k127_6109228_3 serine threonine protein kinase K12132 - 2.7.11.1 1.078e-204 671.0
TLS3_k127_6109228_30 of the alpha beta superfamily K06889 - - 0.0000002704 62.0
TLS3_k127_6109228_31 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000005232 61.0
TLS3_k127_6109228_32 Sigma-54 interaction domain K07712 - - 0.000004674 53.0
TLS3_k127_6109228_33 - - - - 0.0003329 49.0
TLS3_k127_6109228_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 4.816e-201 646.0
TLS3_k127_6109228_5 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 426.0
TLS3_k127_6109228_6 SpoIVB peptidase S55 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 372.0
TLS3_k127_6109228_7 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 323.0
TLS3_k127_6109228_8 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001543 288.0
TLS3_k127_6109228_9 Oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002285 268.0
TLS3_k127_6129830_0 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 303.0
TLS3_k127_6129830_1 GMC oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007944 281.0
TLS3_k127_6129830_10 - - - - 0.0006281 49.0
TLS3_k127_6129830_2 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000002563 237.0
TLS3_k127_6129830_3 Protein of unknown function DUF86 - - - 0.000000000000000000000000002479 113.0
TLS3_k127_6129830_4 protein serine/threonine phosphatase activity - - - 0.0000000000000000000000321 109.0
TLS3_k127_6129830_5 Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000476 102.0
TLS3_k127_6129830_6 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000003165 62.0
TLS3_k127_6129830_8 PFAM YcfA-like protein K07339 - - 0.00000005295 57.0
TLS3_k127_6129830_9 integral membrane protein - - - 0.000006479 57.0
TLS3_k127_6156435_0 DNA Topoisomerase IV K02469 - 5.99.1.3 3.315e-303 951.0
TLS3_k127_6156435_1 Urocanase Rossmann-like domain K01712 - 4.2.1.49 4.677e-273 848.0
TLS3_k127_6156435_10 Molybdopterin converting factor subunit K03635,K21142 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000093 205.0
TLS3_k127_6156435_11 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000005958 195.0
TLS3_k127_6156435_12 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000283 166.0
TLS3_k127_6156435_13 ATP-dependent protease La (LON) substrate-binding domain K01338 - 3.4.21.53 0.0000000000000000000000000000000000000001048 161.0
TLS3_k127_6156435_15 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000007711 113.0
TLS3_k127_6156435_16 - - - - 0.0000000000000000000007693 109.0
TLS3_k127_6156435_17 Transcription factor zinc-finger K09981 - - 0.00000000000001263 77.0
TLS3_k127_6156435_18 cheY-homologous receiver domain - - - 0.00000000000005069 78.0
TLS3_k127_6156435_19 Resolvase, N terminal domain - - - 0.00000004222 60.0
TLS3_k127_6156435_2 ATPases associated with a variety of cellular activities K06147 - - 1.722e-204 653.0
TLS3_k127_6156435_3 Aromatic amino acid lyase K01745 - 4.3.1.3 1.386e-197 627.0
TLS3_k127_6156435_4 Amidohydrolase family K05603 - 3.5.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 455.0
TLS3_k127_6156435_5 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 403.0
TLS3_k127_6156435_6 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 376.0
TLS3_k127_6156435_7 D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008477 351.0
TLS3_k127_6156435_8 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001501 273.0
TLS3_k127_6156435_9 Predicted integral membrane protein (DUF2270) - - - 0.000000000000000000000000000000000000000000000000000000000000000111 232.0
TLS3_k127_6156480_0 Carboxypeptidase regulatory-like domain - - - 1.171e-254 821.0
TLS3_k127_6156480_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000003278 272.0
TLS3_k127_6156480_2 peroxiredoxin activity K03564 - 1.11.1.15 0.0000000000000002119 82.0
TLS3_k127_6156480_3 peroxiredoxin activity K03564 - 1.11.1.15 0.000000000001865 70.0
TLS3_k127_6163345_0 Carboxyl transferase domain - - - 1.48e-235 740.0
TLS3_k127_6163345_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007741 308.0
TLS3_k127_6163345_2 Zn peptidase - - - 0.000000000000000000000000000000000000000000000000000000000005672 224.0
TLS3_k127_6163345_3 PFAM thioesterase superfamily K07107 - - 0.000000000000000000000000000000000000188 147.0
TLS3_k127_6163345_4 - - - - 0.000000000000000000000006601 109.0
TLS3_k127_6169487_0 Carboxypeptidase regulatory-like domain - - - 7.114e-234 760.0
TLS3_k127_6169487_1 Carboxypeptidase regulatory-like domain - - - 3.628e-222 728.0
TLS3_k127_6169487_10 - - - - 0.0000000000000000000000000000000000005827 155.0
TLS3_k127_6169487_11 Pilus assembly protein PilX K02673 - - 0.000000000000000001891 100.0
TLS3_k127_6169487_12 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000003285 78.0
TLS3_k127_6169487_13 type IV pilus modification protein PilV K02671 - - 0.0000005783 57.0
TLS3_k127_6169487_15 Beta-galactosidase K12308 - 3.2.1.23 0.0002584 55.0
TLS3_k127_6169487_16 Belongs to the 'phage' integrase family - - - 0.0003314 43.0
TLS3_k127_6169487_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003286 471.0
TLS3_k127_6169487_3 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 466.0
TLS3_k127_6169487_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 360.0
TLS3_k127_6169487_5 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000129 291.0
TLS3_k127_6169487_6 Chlorite dismutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001018 280.0
TLS3_k127_6169487_7 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000003206 248.0
TLS3_k127_6169487_8 Membrane - - - 0.000000000000000000000000000000000000000000000000001072 206.0
TLS3_k127_6169487_9 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.000000000000000000000000000000000000003716 149.0
TLS3_k127_6189955_0 Heat shock 70 kDa protein K04043 - - 9.661e-233 735.0
TLS3_k127_6189955_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 581.0
TLS3_k127_6189955_10 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000001788 265.0
TLS3_k127_6189955_11 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003617 257.0
TLS3_k127_6189955_12 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000005791 236.0
TLS3_k127_6189955_13 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000001359 222.0
TLS3_k127_6189955_14 Disulphide isomerase - - - 0.000000000000000000000000000000000000000000000000000002035 197.0
TLS3_k127_6189955_15 nucleotide metabolic process - - - 0.00000000000000000000000000000000000000000000000000001271 198.0
TLS3_k127_6189955_16 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000006394 174.0
TLS3_k127_6189955_17 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000004337 161.0
TLS3_k127_6189955_18 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.0000000000000000000000000000003144 132.0
TLS3_k127_6189955_19 - - - - 0.0000000000000000000000000003399 119.0
TLS3_k127_6189955_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 419.0
TLS3_k127_6189955_20 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000132 113.0
TLS3_k127_6189955_21 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000001056 76.0
TLS3_k127_6189955_22 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.000004449 53.0
TLS3_k127_6189955_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 419.0
TLS3_k127_6189955_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409,K03070 GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009696 358.0
TLS3_k127_6189955_5 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 357.0
TLS3_k127_6189955_6 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000064 315.0
TLS3_k127_6189955_7 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003888 285.0
TLS3_k127_6189955_8 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001269 258.0
TLS3_k127_6189955_9 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005691 260.0
TLS3_k127_6228120_0 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 437.0
TLS3_k127_6228120_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 417.0
TLS3_k127_6228120_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005567 358.0
TLS3_k127_6228120_3 aspartic-type endopeptidase activity K06985 - - 0.000000000000000000006305 98.0
TLS3_k127_6229819_0 ATPase family associated with various cellular activities (AAA) - - - 2.356e-204 653.0
TLS3_k127_6229819_1 A-macroglobulin complement component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 653.0
TLS3_k127_6229819_10 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000001124 229.0
TLS3_k127_6229819_11 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000007082 205.0
TLS3_k127_6229819_12 penicillin binding - - - 0.00000000000000000000000000000000000000000000000001987 200.0
TLS3_k127_6229819_13 HIT domain K02503 - - 0.0000000000000000000000000000000000000000000001934 169.0
TLS3_k127_6229819_14 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000007894 174.0
TLS3_k127_6229819_15 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000002291 167.0
TLS3_k127_6229819_16 Tetratricopeptide repeat - - - 0.00000000000000000000000000000002602 139.0
TLS3_k127_6229819_17 Domain of unknown function (DUF4349) - - - 0.00000000000000000000000003195 120.0
TLS3_k127_6229819_18 Cytochrome c biogenesis protein transmembrane region K04084 - 1.8.1.8 0.0000000000000000002735 94.0
TLS3_k127_6229819_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 562.0
TLS3_k127_6229819_20 von Willebrand factor, type A K07114 - - 0.000000000000000005168 96.0
TLS3_k127_6229819_22 - - - - 0.0000000008929 70.0
TLS3_k127_6229819_23 - K05826 - - 0.000000001086 63.0
TLS3_k127_6229819_24 domain protein K14475 - - 0.00004589 53.0
TLS3_k127_6229819_25 Belongs to the small GTPase superfamily. Arf family K12272 GO:0003674,GO:0005047,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005785,GO:0005789,GO:0005791,GO:0012505,GO:0016020,GO:0030867,GO:0031090,GO:0031984,GO:0032991,GO:0042175,GO:0043021,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0098588,GO:0098796,GO:0098827 - 0.0002544 44.0
TLS3_k127_6229819_3 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 476.0
TLS3_k127_6229819_4 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 444.0
TLS3_k127_6229819_5 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 423.0
TLS3_k127_6229819_6 Phage shock protein A, PspA K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007819 263.0
TLS3_k127_6229819_7 ABC transporter related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001887 258.0
TLS3_k127_6229819_8 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002834 251.0
TLS3_k127_6229819_9 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000779 242.0
TLS3_k127_6241515_0 regulation of response to stimulus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006981 490.0
TLS3_k127_6241515_1 COG1943 Transposase and inactivated derivatives - - - 0.0005617 48.0
TLS3_k127_6241515_2 Glutathione peroxidase - - - 0.0006272 49.0
TLS3_k127_6242841_0 repeat protein - - - 9.314e-276 864.0
TLS3_k127_6242841_1 peptide catabolic process - - - 8.068e-229 720.0
TLS3_k127_6242841_10 Acetyltransferase (GNAT) domain K03824 - - 0.0000000000000000000000000000000000000000001549 164.0
TLS3_k127_6242841_11 acetoacetate decarboxylase activity - - - 0.0000000000000000000000000000000000000000163 171.0
TLS3_k127_6242841_13 OmpA family - - - 0.00000000000000000000000000006253 128.0
TLS3_k127_6242841_14 Domain of unknown function (DUF4136) - - - 0.000000000000000000007387 94.0
TLS3_k127_6242841_15 Domain of unknown function (DUF4136) - - - 0.00000000000002566 80.0
TLS3_k127_6242841_2 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 441.0
TLS3_k127_6242841_3 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 412.0
TLS3_k127_6242841_4 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 384.0
TLS3_k127_6242841_5 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 313.0
TLS3_k127_6242841_6 Hydrolases of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 302.0
TLS3_k127_6242841_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001484 276.0
TLS3_k127_6242841_8 Sodium Bile acid symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001204 252.0
TLS3_k127_6242841_9 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001695 237.0
TLS3_k127_6247434_0 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 2.303e-267 833.0
TLS3_k127_6247434_1 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 464.0
TLS3_k127_6247434_2 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 293.0
TLS3_k127_6247434_3 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000003246 187.0
TLS3_k127_6247434_4 Histidine kinase K10681 - 2.7.13.3 0.0000000000000000000000000000000000000000000001251 189.0
TLS3_k127_6247434_5 - - - - 0.000000000000000000000000000000000000000003183 165.0
TLS3_k127_6247434_6 Bacterial protein of unknown function (DUF937) - - - 0.0000000000000000000000000000002555 130.0
TLS3_k127_6247434_7 PFAM Fasciclin domain - - - 0.0000000000000000000000000000003686 128.0
TLS3_k127_6247434_8 ABC-2 family transporter protein - - - 0.0000000000000000000000002981 115.0
TLS3_k127_6247434_9 Dodecin K09165 - - 0.0000000000000000000008901 98.0
TLS3_k127_6258947_0 TIGRFAM methylmalonyl-CoA mutase, large subunit K01847,K01848 - 5.4.99.2 1.015e-231 728.0
TLS3_k127_6258947_1 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 426.0
TLS3_k127_6258947_10 PQQ-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000003797 227.0
TLS3_k127_6258947_11 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000001574 204.0
TLS3_k127_6258947_12 PFAM Forkhead-associated protein - - - 0.000000000000000000004251 101.0
TLS3_k127_6258947_13 Yip1 domain - - - 0.000000003238 67.0
TLS3_k127_6258947_14 RDD family - - - 0.00000005165 62.0
TLS3_k127_6258947_2 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 390.0
TLS3_k127_6258947_3 COGs COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 348.0
TLS3_k127_6258947_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 338.0
TLS3_k127_6258947_5 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 331.0
TLS3_k127_6258947_6 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 317.0
TLS3_k127_6258947_7 polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007579 312.0
TLS3_k127_6258947_8 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 305.0
TLS3_k127_6258947_9 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000142 289.0
TLS3_k127_6263245_0 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000003596 124.0
TLS3_k127_6263245_1 domain protein K14194 - - 0.00000000000000000001475 106.0
TLS3_k127_6263245_2 DoxX K15977 - - 0.0000000000000008669 83.0
TLS3_k127_6263245_3 domain protein - - - 0.00000000001693 77.0
TLS3_k127_6282314_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 4.632e-310 960.0
TLS3_k127_6282314_1 GTP-binding protein TypA K06207 - - 1.512e-257 807.0
TLS3_k127_6282314_10 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000181 268.0
TLS3_k127_6282314_11 COG1230 Co Zn Cd efflux system component K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001549 268.0
TLS3_k127_6282314_12 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000008335 234.0
TLS3_k127_6282314_13 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000001239 218.0
TLS3_k127_6282314_14 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000005889 211.0
TLS3_k127_6282314_15 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000001452 194.0
TLS3_k127_6282314_16 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000003871 178.0
TLS3_k127_6282314_17 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000001614 173.0
TLS3_k127_6282314_18 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000005735 171.0
TLS3_k127_6282314_19 Bacterial regulatory proteins, luxR family - - - 0.000000000000000000000000000000000000001109 157.0
TLS3_k127_6282314_2 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 454.0
TLS3_k127_6282314_20 HD domain K07023 - - 0.000000000000000000000000000000000000001284 154.0
TLS3_k127_6282314_21 Two component regulator propeller - - - 0.000000000000000000000000000000000000004079 169.0
TLS3_k127_6282314_22 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000003609 159.0
TLS3_k127_6282314_23 AI-2E family transporter - - - 0.000000000000000000000000000000000702 146.0
TLS3_k127_6282314_24 bacterial (prokaryotic) histone like domain K03530 - - 0.000000000000000000000000000000002475 134.0
TLS3_k127_6282314_25 - - - - 0.0000000000000000000000000000001527 128.0
TLS3_k127_6282314_26 - catabolite gene activator and regulatory subunit of cAMP-dependent protein K10914 - - 0.000000000000000000000002411 111.0
TLS3_k127_6282314_27 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000004003 106.0
TLS3_k127_6282314_28 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000009077 83.0
TLS3_k127_6282314_29 zinc-ribbon domain - - - 0.0000000000000002125 89.0
TLS3_k127_6282314_3 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007661 430.0
TLS3_k127_6282314_31 Tetratricopeptide repeat - - - 0.00000001977 66.0
TLS3_k127_6282314_32 general secretion pathway protein - - - 0.00001745 55.0
TLS3_k127_6282314_33 PFAM Fimbrial assembly family protein K02663 - - 0.00003632 53.0
TLS3_k127_6282314_34 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00004554 55.0
TLS3_k127_6282314_35 cellulose binding - - - 0.0003644 52.0
TLS3_k127_6282314_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 422.0
TLS3_k127_6282314_5 Belongs to the pyruvate kinase family K00873 GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 400.0
TLS3_k127_6282314_6 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 367.0
TLS3_k127_6282314_7 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 321.0
TLS3_k127_6282314_8 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 293.0
TLS3_k127_6282314_9 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002787 277.0
TLS3_k127_6293117_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 524.0
TLS3_k127_6293117_1 ATPases associated with a variety of cellular activities K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 385.0
TLS3_k127_6293117_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000003835 237.0
TLS3_k127_6293117_3 TIGRFAM methyltransferase FkbM family - - - 0.000002905 53.0
TLS3_k127_6293504_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 612.0
TLS3_k127_6293504_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 580.0
TLS3_k127_6293504_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009932 472.0
TLS3_k127_6293504_3 Transporter-associated region K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 444.0
TLS3_k127_6293504_4 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 338.0
TLS3_k127_6293504_5 COG0859 ADP-heptose LPS heptosyltransferase K02841,K02849 - - 0.00000000000000000000000000000001828 139.0
TLS3_k127_6293504_6 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000689 112.0
TLS3_k127_6293504_7 phosphorelay signal transduction system - - - 0.00000001343 66.0
TLS3_k127_6293504_8 self proteolysis - - - 0.000009504 57.0
TLS3_k127_6404922_0 Ion transport protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 350.0
TLS3_k127_6404922_1 Membrane protein TerC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 315.0
TLS3_k127_6404922_2 Cytochrome P460 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001129 243.0
TLS3_k127_6404922_3 hydrolase of the alpha beta superfamily K07017 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001442 255.0
TLS3_k127_6404922_4 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.00000000000000000000000000000000000000000000000000000000000000001032 229.0
TLS3_k127_6404922_5 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000364 175.0
TLS3_k127_6404922_6 DinB family - - - 0.000000000000000000000004391 109.0
TLS3_k127_6404922_7 SnoaL-like polyketide cyclase - - - 0.00000000000005562 78.0
TLS3_k127_6404922_8 Transcriptional regulator - - - 0.00000000000007685 77.0
TLS3_k127_6422059_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 383.0
TLS3_k127_6422059_1 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 370.0
TLS3_k127_6422059_10 - - - - 0.000000000000000000000007985 112.0
TLS3_k127_6422059_11 Bacterial DNA-binding protein K03530 - - 0.00000000000000000000001325 103.0
TLS3_k127_6422059_12 two component, sigma54 specific, transcriptional regulator, Fis family K07713 - - 0.000000000000000000003634 97.0
TLS3_k127_6422059_13 Acetyltransferase K06976 - - 0.00000000000000008907 91.0
TLS3_k127_6422059_14 COG0500 SAM-dependent methyltransferases K03183 - 2.1.1.163,2.1.1.201 0.000000000003039 75.0
TLS3_k127_6422059_15 - - - - 0.00000004411 63.0
TLS3_k127_6422059_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 324.0
TLS3_k127_6422059_3 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 308.0
TLS3_k127_6422059_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000002432 189.0
TLS3_k127_6422059_5 OsmC-like protein K07397 - - 0.00000000000000000000000000000000000000003004 157.0
TLS3_k127_6422059_6 - - - - 0.000000000000000000000000000000000000001358 151.0
TLS3_k127_6422059_7 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000001104 138.0
TLS3_k127_6422059_8 - - - - 0.0000000000000000000000000145 121.0
TLS3_k127_6422059_9 IMP dehydrogenase activity - - - 0.000000000000000000000005645 106.0
TLS3_k127_6480192_0 Forkhead associated domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005523 341.0
TLS3_k127_6480192_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 292.0
TLS3_k127_6480192_10 PFAM Intradiol ring-cleavage dioxygenase, C-terminal K03381 - 1.13.11.1 0.00000000000000000005537 100.0
TLS3_k127_6480192_11 FaeA-like protein K02475,K11692 - - 0.0000000000000004296 83.0
TLS3_k127_6480192_12 phosphorelay signal transduction system - - - 0.000000000002971 72.0
TLS3_k127_6480192_2 PA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002684 285.0
TLS3_k127_6480192_3 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001332 271.0
TLS3_k127_6480192_4 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000002614 222.0
TLS3_k127_6480192_5 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000002459 199.0
TLS3_k127_6480192_6 PFAM OsmC family protein K04063 - - 0.0000000000000000000000000000000000000000000024 168.0
TLS3_k127_6480192_7 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000002745 168.0
TLS3_k127_6480192_8 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000139 145.0
TLS3_k127_6480192_9 Histidine kinase - - - 0.0000000000000000000000004953 108.0
TLS3_k127_6483545_0 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000002947 223.0
TLS3_k127_6483545_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000004819 173.0
TLS3_k127_6483545_2 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000001867 121.0
TLS3_k127_6483545_3 - - - - 0.000000000009586 74.0
TLS3_k127_6483545_4 Putative zinc-finger - - - 0.0002806 51.0
TLS3_k127_649983_0 Carboxypeptidase regulatory-like domain - - - 1.236e-261 844.0
TLS3_k127_649983_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 567.0
TLS3_k127_649983_2 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009617 334.0
TLS3_k127_649983_3 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000003728 271.0
TLS3_k127_649983_4 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000106 252.0
TLS3_k127_649983_5 sequence-specific DNA binding - - - 0.0000000000000000000000004964 113.0
TLS3_k127_649983_6 Transglutaminase-like superfamily - - - 0.000000001354 68.0
TLS3_k127_6502424_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1085.0
TLS3_k127_6502424_1 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 344.0
TLS3_k127_6502424_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000007357 185.0
TLS3_k127_6502424_3 - - - - 0.00000000000000000000000000000000006852 144.0
TLS3_k127_6502424_4 metallopeptidase activity - - - 0.0000000000000000000000000000000001959 142.0
TLS3_k127_6502424_5 Penicillinase repressor - - - 0.000000000000000000002322 102.0
TLS3_k127_6502424_6 Belongs to the peptidase M48B family - - - 0.000000000000000000009993 104.0
TLS3_k127_6502424_7 TonB-dependent receptor K02014 - - 0.00000000000000002685 97.0
TLS3_k127_6514881_0 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 498.0
TLS3_k127_6514881_1 SMART ATPase, AAA type, core K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 311.0
TLS3_k127_6514881_2 Bacterial transcriptional activator domain - - - 0.000005377 59.0
TLS3_k127_6534812_0 Transcriptional regulator K03603,K05799 - - 8.855e-216 700.0
TLS3_k127_6534812_1 ORF6N domain - - - 0.0000000000000000000123 94.0
TLS3_k127_6538548_0 CarboxypepD_reg-like domain - - - 2.631e-236 777.0
TLS3_k127_6538548_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 415.0
TLS3_k127_6538548_2 candidate b-glycosidase, glycoside hydrolase family 8 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 394.0
TLS3_k127_6538548_3 protein with SCP PR1 domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 368.0
TLS3_k127_6538548_4 COG3209 Rhs family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002713 302.0
TLS3_k127_6538548_5 PFAM SEC-C motif domain protein K09858 - - 0.0000000000000000000000000000000000000000004143 162.0
TLS3_k127_6538548_6 - - - - 0.000001515 62.0
TLS3_k127_6538548_7 - - - - 0.000287 54.0
TLS3_k127_6592418_0 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 383.0
TLS3_k127_6592418_1 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K07083,K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 347.0
TLS3_k127_6592418_2 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 293.0
TLS3_k127_6661468_0 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 407.0
TLS3_k127_6661468_1 COG3209 Rhs family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 310.0
TLS3_k127_6661468_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000946 305.0
TLS3_k127_6704857_0 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007672 572.0
TLS3_k127_6704857_1 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000009297 206.0
TLS3_k127_6710257_0 Heat shock 70 kDa protein K04043 - - 8.762e-294 912.0
TLS3_k127_6710257_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 1.063e-254 799.0
TLS3_k127_6710257_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000001555 127.0
TLS3_k127_6710257_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41 0.00000000000000000000000000002262 125.0
TLS3_k127_6710257_2 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 477.0
TLS3_k127_6710257_3 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 413.0
TLS3_k127_6710257_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 392.0
TLS3_k127_6710257_5 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000537 269.0
TLS3_k127_6710257_6 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000003902 198.0
TLS3_k127_6710257_7 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000000000268 173.0
TLS3_k127_6710257_8 MerR HTH family regulatory protein K13640 - - 0.000000000000000000000000000000000000339 143.0
TLS3_k127_6710257_9 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.00000000000000000000000000000000008577 139.0
TLS3_k127_6738093_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 312.0
TLS3_k127_6738093_1 chaperone-mediated protein folding - - - 0.00000000000000000000000000000000000000000000000000000014 218.0
TLS3_k127_6738093_2 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000004992 192.0
TLS3_k127_6738276_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 539.0
TLS3_k127_6738276_1 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 442.0
TLS3_k127_6738276_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 428.0
TLS3_k127_6738276_3 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 368.0
TLS3_k127_6738276_4 COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 304.0
TLS3_k127_6738276_5 3-demethylubiquinone-9 3-O-methyltransferase activity K15257,K16868,K18827,K20444 - 2.1.1.265,2.1.1.294,2.7.1.181 0.00000000000000000000000000000000000000000000000007293 189.0
TLS3_k127_6738276_6 Parallel beta-helix repeats - - - 0.00000000000000000000000000000000005226 143.0
TLS3_k127_6738276_7 Nodulation protein S (NodS) - - - 0.0000000000000000000003773 105.0
TLS3_k127_6738276_8 transferase activity, transferring glycosyl groups - - - 0.0000000000001097 83.0
TLS3_k127_6738276_9 Glycosyl transferase 4-like - - - 0.000000000001709 79.0
TLS3_k127_674823_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 2.22e-248 781.0
TLS3_k127_674823_1 Domain in cystathionine beta-synthase and other proteins. - - - 1.012e-232 736.0
TLS3_k127_674823_10 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000124 272.0
TLS3_k127_674823_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000006551 250.0
TLS3_k127_674823_12 cytochrome c nitrite reductase K15876 - - 0.000000000000000000000000000000000000000000000000000000000001409 213.0
TLS3_k127_674823_13 cyclic nucleotide-binding K01420,K10914 - - 0.0000000000000000000000000000000000000000001004 168.0
TLS3_k127_674823_14 Chloramphenicol O-acetyltransferase K19271 - 2.3.1.28 0.0000000000000000000000000000000000000000001959 166.0
TLS3_k127_674823_15 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000002168 151.0
TLS3_k127_674823_16 Universal stress protein family - - - 0.000000000000000000000000000000000118 145.0
TLS3_k127_674823_18 AMP binding K06149 - - 0.000000000000000002232 96.0
TLS3_k127_674823_19 AMP binding - - - 0.00000000000000005381 93.0
TLS3_k127_674823_2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 2.326e-232 726.0
TLS3_k127_674823_20 12 heme-binding sites - - - 0.000000000000001776 86.0
TLS3_k127_674823_21 Universal stress protein family - - - 0.000000000004719 77.0
TLS3_k127_674823_22 Universal stress protein family - - - 0.0000000001947 72.0
TLS3_k127_674823_23 Cytochrome c553 K08738 - - 0.00003261 50.0
TLS3_k127_674823_24 Class III cytochrome C family - - - 0.0002646 50.0
TLS3_k127_674823_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 610.0
TLS3_k127_674823_4 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 609.0
TLS3_k127_674823_5 Zinc-binding dehydrogenase K00008,K00148,K18369 - 1.1.1.14,1.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 582.0
TLS3_k127_674823_6 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 509.0
TLS3_k127_674823_7 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 415.0
TLS3_k127_674823_8 D-aminopeptidase K16203 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 316.0
TLS3_k127_674823_9 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 294.0
TLS3_k127_675349_0 iron-nicotianamine transmembrane transporter activity - - - 4.387e-287 906.0
TLS3_k127_675349_1 Zinc carboxypeptidase - - - 4.336e-223 716.0
TLS3_k127_675349_10 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000000000002981 145.0
TLS3_k127_675349_11 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.00000000000000000000001146 106.0
TLS3_k127_675349_12 Domain of unknown function (DUF1844) - - - 0.00000000001595 72.0
TLS3_k127_675349_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 5.364e-194 622.0
TLS3_k127_675349_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006644 371.0
TLS3_k127_675349_4 ABC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 352.0
TLS3_k127_675349_5 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 322.0
TLS3_k127_675349_6 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000002866 254.0
TLS3_k127_675349_7 TIGRFAM MazG family protein K02428,K04765 - 3.6.1.66,3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000002453 252.0
TLS3_k127_675349_8 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000002322 252.0
TLS3_k127_675349_9 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000001237 200.0
TLS3_k127_680278_0 PrkA AAA domain protein K07180 - - 2.847e-303 943.0
TLS3_k127_680278_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.155e-261 833.0
TLS3_k127_680278_10 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003587 280.0
TLS3_k127_680278_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000204 245.0
TLS3_k127_680278_12 spore germination - - - 0.000000000000000000000000000000000000000000000000000000000000000002073 237.0
TLS3_k127_680278_13 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000002036 233.0
TLS3_k127_680278_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000006814 235.0
TLS3_k127_680278_15 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177,K03483 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000002375 222.0
TLS3_k127_680278_16 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000009777 208.0
TLS3_k127_680278_17 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000003614 188.0
TLS3_k127_680278_18 - - - - 0.0000000000000000000000000000000000000000000001088 176.0
TLS3_k127_680278_19 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000714 163.0
TLS3_k127_680278_2 Phosphoenolpyruvate carboxykinase K01610 - 4.1.1.49 5.436e-215 679.0
TLS3_k127_680278_20 HIT domain K02503 - - 0.000000000000000000000000000000000000003404 149.0
TLS3_k127_680278_21 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000001195 149.0
TLS3_k127_680278_22 Ferredoxin K00529,K04755,K08952,K08953,K08954,K15765 GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 1.18.1.3 0.00000000000000000000000000000009117 136.0
TLS3_k127_680278_23 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000002229 122.0
TLS3_k127_680278_24 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000000000000000000003454 98.0
TLS3_k127_680278_25 Putative restriction endonuclease - - - 0.000000000000000000004634 100.0
TLS3_k127_680278_26 3D domain - - - 0.0000000000000000009509 93.0
TLS3_k127_680278_27 Putative peptidoglycan binding domain - - - 0.0000001131 57.0
TLS3_k127_680278_28 Modulates RecA activity K03565 - - 0.0000001355 62.0
TLS3_k127_680278_29 Bacterial PH domain - - - 0.000005413 55.0
TLS3_k127_680278_3 SpoVR like protein K06415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 554.0
TLS3_k127_680278_4 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 490.0
TLS3_k127_680278_5 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 493.0
TLS3_k127_680278_6 D-alanyl-d-alanine carboxypeptidase K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 324.0
TLS3_k127_680278_7 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006972 308.0
TLS3_k127_680278_8 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009648 297.0
TLS3_k127_680278_9 Trypsin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003171 291.0
TLS3_k127_683285_0 Serine Threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000001314 207.0
TLS3_k127_683285_1 WD40 domain protein beta Propeller - - - 0.0000000000000000000000000000000008179 144.0
TLS3_k127_683285_2 regulation of methylation-dependent chromatin silencing K07454 - - 0.0000000000000000000000000000005294 125.0
TLS3_k127_683285_3 - - - - 0.0002773 49.0
TLS3_k127_6885134_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 7.403e-267 859.0
TLS3_k127_6885134_1 beta-galactosidase activity - - - 8.986e-248 777.0
TLS3_k127_6885134_2 PFAM UDP-galactopyranose mutase, C-terminal K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 552.0
TLS3_k127_6885134_3 6-phospho-beta-galactosidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005289 510.0
TLS3_k127_6885134_4 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000003897 222.0
TLS3_k127_6885134_5 His Kinase A (phosphoacceptor) domain K20973 - 2.7.13.3 0.00000000000000003073 88.0
TLS3_k127_6885134_6 phosphorelay signal transduction system - - - 0.00000000002045 64.0
TLS3_k127_6885134_7 photoactive yellow protein - - - 0.0001975 48.0
TLS3_k127_6894781_0 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009571 431.0
TLS3_k127_6894781_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000270,GO:0000271,GO:0003674,GO:0003824,GO:0003977,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0030203,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 392.0
TLS3_k127_6894781_2 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 346.0
TLS3_k127_6894781_3 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 314.0
TLS3_k127_6894781_4 Required for morphogenesis under gluconeogenic growth conditions - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 314.0
TLS3_k127_6894781_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000003848 183.0
TLS3_k127_6894781_6 Roadblock/LC7 domain - - - 0.00000000000000000000000000000000000000000006128 166.0
TLS3_k127_6894781_7 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000001341 81.0
TLS3_k127_6894781_8 Virulence factor BrkB K07058 - - 0.00000000000009376 81.0
TLS3_k127_6894781_9 Tetratricopeptide repeat - - - 0.0000001934 62.0
TLS3_k127_6925073_0 Sh3 type 3 domain protein K09774 - - 4.865e-249 811.0
TLS3_k127_6925073_1 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 418.0
TLS3_k127_6925073_10 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07712 - - 0.00000000000001153 79.0
TLS3_k127_6925073_11 Transcriptional regulatory protein, C terminal - - - 0.00000000005155 66.0
TLS3_k127_6925073_2 Ion transport protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 313.0
TLS3_k127_6925073_3 Truncated hemoglobins K06886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001449 247.0
TLS3_k127_6925073_4 Domain of unknown function (DUF4118) - - - 0.0000000000000000000000000000000000000000000000000000000000007059 236.0
TLS3_k127_6925073_5 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000004359 181.0
TLS3_k127_6925073_6 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000000000000000004422 147.0
TLS3_k127_6925073_7 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.00000000000000000000000000000000000001084 149.0
TLS3_k127_6925073_8 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.0000000000000000000000000000000000002888 142.0
TLS3_k127_6925073_9 Histidine kinase - - - 0.000000000000000000000004632 119.0
TLS3_k127_6946922_0 ASPIC and UnbV - - - 7.094e-211 672.0
TLS3_k127_6946922_1 Cyclomaltodextrinase, N-terminal K21575 - 3.2.1.135 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 496.0
TLS3_k127_6946922_2 CarboxypepD_reg-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 497.0
TLS3_k127_6946922_3 Phosphofructokinase K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 302.0
TLS3_k127_6946922_4 ROK family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001131 253.0
TLS3_k127_6946922_5 TPR repeat - - - 0.00000000000000000000000000000000000000000000001531 190.0
TLS3_k127_6946922_6 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000001806 139.0
TLS3_k127_6946922_7 - - - - 0.0000000000000000000000000001519 122.0
TLS3_k127_6946922_8 ECF sigma factor - - - 0.0000000000000001071 85.0
TLS3_k127_6971373_0 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003416 243.0
TLS3_k127_6971373_1 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000004465 201.0
TLS3_k127_6971373_2 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000001855 203.0
TLS3_k127_6971373_3 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.000000000000000002528 96.0
TLS3_k127_697151_0 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000008002 192.0
TLS3_k127_697151_1 - - - - 0.0000000001598 73.0
TLS3_k127_697151_2 - - - - 0.0000000009741 60.0
TLS3_k127_7016710_0 NB-ARC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001882 258.0
TLS3_k127_7016710_1 ORF6N domain - - - 0.000000000000000000000000000000000000000000000000238 183.0
TLS3_k127_7016710_4 - - - - 0.0000000000000000000000009992 105.0
TLS3_k127_7016710_5 Transglycosylase associated protein - - - 0.00000000000000000000006442 103.0
TLS3_k127_7016710_6 NB-ARC domain - - - 0.000000000001478 73.0
TLS3_k127_7016710_7 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000002268 61.0
TLS3_k127_7016710_8 Belongs to the UPF0761 family K07058 - - 0.00000006845 58.0
TLS3_k127_7018425_0 domain protein - - - 0.0 1095.0
TLS3_k127_7018425_1 Belongs to the glycosyl hydrolase 3 family K05349 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.21 7.719e-265 836.0
TLS3_k127_7018425_10 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009317 381.0
TLS3_k127_7018425_11 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 368.0
TLS3_k127_7018425_12 YdjC-like protein K03478 - 3.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 297.0
TLS3_k127_7018425_13 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002646 281.0
TLS3_k127_7018425_14 ROK family - - - 0.0000000000000000000000000000000000000000000000000000000000001183 228.0
TLS3_k127_7018425_15 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000006121 151.0
TLS3_k127_7018425_17 TPR repeat - - - 0.00000000001942 76.0
TLS3_k127_7018425_2 ASPIC and UnbV - - - 1.777e-241 759.0
TLS3_k127_7018425_3 Putative carbohydrate binding domain K12373 - 3.2.1.52 2.983e-234 744.0
TLS3_k127_7018425_4 ASPIC and UnbV - - - 8.127e-226 711.0
TLS3_k127_7018425_5 ASPIC and UnbV - - - 9.148e-202 643.0
TLS3_k127_7018425_6 TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004603 596.0
TLS3_k127_7018425_7 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005915 446.0
TLS3_k127_7018425_8 PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme K07404 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 411.0
TLS3_k127_7018425_9 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009807 426.0
TLS3_k127_7029748_0 two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009516 530.0
TLS3_k127_7029748_1 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 391.0
TLS3_k127_7029748_2 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000005596 176.0
TLS3_k127_7029748_3 Radical SAM K22227 - - 0.00000000000000000000000000000000000000006273 166.0
TLS3_k127_7029748_4 Domain of unknown function (DUF4252) - - - 0.0000000000000000000000000000000003237 138.0
TLS3_k127_7029748_5 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000001007 143.0
TLS3_k127_7029748_6 - - - - 0.000003205 56.0
TLS3_k127_7029748_7 von Willebrand factor, type A - - - 0.000004208 59.0
TLS3_k127_7029748_8 DNA-templated transcription, initiation - - - 0.000005896 56.0
TLS3_k127_7032412_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1022.0
TLS3_k127_7032412_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 2.002e-311 981.0
TLS3_k127_7032412_10 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003175 281.0
TLS3_k127_7032412_11 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000001098 270.0
TLS3_k127_7032412_12 DEAD DEAH box helicase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004509 261.0
TLS3_k127_7032412_13 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008306 259.0
TLS3_k127_7032412_14 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000003379 244.0
TLS3_k127_7032412_15 DSHCT - - - 0.000000000000000000000000000000000000000000000000000000000000004088 239.0
TLS3_k127_7032412_16 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000000000000000000002231 225.0
TLS3_k127_7032412_17 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000001659 156.0
TLS3_k127_7032412_18 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000001463 133.0
TLS3_k127_7032412_19 - - - - 0.000000000000000000000000000001218 136.0
TLS3_k127_7032412_2 PFAM aminotransferase, class I K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 532.0
TLS3_k127_7032412_20 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000002769 123.0
TLS3_k127_7032412_21 nuclear chromosome segregation - - - 0.00000000000000000000000003584 123.0
TLS3_k127_7032412_22 cheY-homologous receiver domain - - - 0.0000000000000000000002454 100.0
TLS3_k127_7032412_23 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000001603 97.0
TLS3_k127_7032412_24 Regulatory protein, FmdB - - - 0.00000000000000000002015 94.0
TLS3_k127_7032412_25 Belongs to the UPF0109 family K06960 - - 0.000000000000001986 78.0
TLS3_k127_7032412_26 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000002515 72.0
TLS3_k127_7032412_27 general stress protein - - - 0.000001903 55.0
TLS3_k127_7032412_28 Tetratricopeptide repeat - - - 0.00002158 55.0
TLS3_k127_7032412_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009495 494.0
TLS3_k127_7032412_4 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 477.0
TLS3_k127_7032412_5 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 408.0
TLS3_k127_7032412_6 Domain of unknown function (DUF1972) K12996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 399.0
TLS3_k127_7032412_7 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 371.0
TLS3_k127_7032412_8 two component, sigma54 specific, transcriptional regulator, Fis family K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 333.0
TLS3_k127_7032412_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000519 288.0
TLS3_k127_7037594_0 metallopeptidase activity K06212,K06402 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 400.0
TLS3_k127_7037594_1 TrkA-C domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 349.0
TLS3_k127_7045711_0 transport - - - 8.761e-313 1000.0
TLS3_k127_7045711_1 PFAM D-aminoacylase, C-terminal region K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 565.0
TLS3_k127_7045711_2 Gamma-glutamyltranspeptidase K00681 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 557.0
TLS3_k127_7045711_3 TonB-dependent Receptor Plug - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006705 571.0
TLS3_k127_7045711_4 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 509.0
TLS3_k127_7045711_5 4Fe-4S binding domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007669 348.0
TLS3_k127_7045711_6 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0006040,GO:0006044,GO:0006046,GO:0008150,GO:0008152,GO:0008448,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046348,GO:0046872,GO:0046914,GO:0046983,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000002866 267.0
TLS3_k127_7045711_7 TPR repeat - - - 0.000000000000000000000000000000000000000000275 174.0
TLS3_k127_7045711_8 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000316 121.0
TLS3_k127_7045711_9 COG3209 Rhs family protein - - - 0.0000000008055 66.0
TLS3_k127_7067688_0 belongs to the sigma-70 factor family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 423.0
TLS3_k127_7067688_1 YCII-related domain - - - 0.000000000000000000000000000000000007308 139.0
TLS3_k127_7094515_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.074e-253 788.0
TLS3_k127_7094515_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 1.714e-242 759.0
TLS3_k127_712006_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 9.986e-285 898.0
TLS3_k127_712006_1 Amidohydrolase family K01466 - 3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 518.0
TLS3_k127_712006_10 InterPro IPR007367 - - - 0.000000000000000000001352 98.0
TLS3_k127_712006_11 Belongs to the allantoicase family K01477 - 3.5.3.4 0.00000000000000003237 82.0
TLS3_k127_712006_12 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000001017 64.0
TLS3_k127_712006_13 integral membrane protein - - - 0.0000000008459 68.0
TLS3_k127_712006_14 abc-type fe3 -hydroxamate transport system, periplasmic component - - - 0.000000001596 60.0
TLS3_k127_712006_16 iron ion homeostasis - - - 0.00000591 59.0
TLS3_k127_712006_2 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 524.0
TLS3_k127_712006_3 Permease K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 338.0
TLS3_k127_712006_4 WD40 repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 337.0
TLS3_k127_712006_5 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000002131 271.0
TLS3_k127_712006_6 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000002247 215.0
TLS3_k127_712006_7 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000002573 211.0
TLS3_k127_712006_8 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000001385 103.0
TLS3_k127_712006_9 abc-type fe3 -hydroxamate transport system, periplasmic component - - - 0.00000000000000000000006367 102.0
TLS3_k127_7137967_0 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 607.0
TLS3_k127_7137967_1 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 437.0
TLS3_k127_7137967_2 Transporter-associated region K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 328.0
TLS3_k127_7137967_3 Protein conserved in bacteria - - - 0.00000000000002243 87.0
TLS3_k127_7173764_0 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 444.0
TLS3_k127_7173764_1 COG0515 Serine threonine protein K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000005195 252.0
TLS3_k127_7173764_2 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000003698 229.0
TLS3_k127_7173764_3 Glyoxalase-like domain K06996 - - 0.00000000000000000000000000000000000000000000000000000005678 197.0
TLS3_k127_7173764_4 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000006577 123.0
TLS3_k127_7173764_5 DNA polymerase K02347 - - 0.000000000000000000000000008606 115.0
TLS3_k127_7173764_8 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00001734 49.0
TLS3_k127_718491_0 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 582.0
TLS3_k127_718491_1 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 567.0
TLS3_k127_718491_10 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000003331 155.0
TLS3_k127_718491_11 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000003761 150.0
TLS3_k127_718491_12 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000009574 134.0
TLS3_k127_718491_13 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000001039 129.0
TLS3_k127_718491_14 competence protein - - - 0.000000000000000000000000000003663 128.0
TLS3_k127_718491_15 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000001398 123.0
TLS3_k127_718491_16 Ribosomal protein L17 K02879 - - 0.00000000000000000000000002496 116.0
TLS3_k127_718491_17 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000007248 106.0
TLS3_k127_718491_18 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000006182 105.0
TLS3_k127_718491_19 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000001063 100.0
TLS3_k127_718491_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008959 475.0
TLS3_k127_718491_20 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000003974 73.0
TLS3_k127_718491_21 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0008150,GO:0040007 - 0.000000146 55.0
TLS3_k127_718491_22 Hypothetical methyltransferase - - - 0.000006103 57.0
TLS3_k127_718491_3 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 447.0
TLS3_k127_718491_4 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 413.0
TLS3_k127_718491_5 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004815 283.0
TLS3_k127_718491_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000389 246.0
TLS3_k127_718491_7 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000148 243.0
TLS3_k127_718491_8 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000001346 182.0
TLS3_k127_718491_9 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000001113 171.0
TLS3_k127_719334_0 MFS/sugar transport protein K16211 - - 1.128e-201 638.0
TLS3_k127_719334_1 Cyclomaltodextrinase, N-terminal K21575 - 3.2.1.135 9.644e-198 634.0
TLS3_k127_719334_2 Domain of unknown function (DUF5110) K01187 - 3.2.1.20 1.266e-196 640.0
TLS3_k127_719334_3 Glucodextranase, domain N K01178 - 3.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 622.0
TLS3_k127_719334_4 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 475.0
TLS3_k127_719334_5 Alpha amylase, catalytic domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 317.0
TLS3_k127_719334_6 Glucokinase K00845 GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000108 236.0
TLS3_k127_719334_7 - - - - 0.0000000000000000000000000003091 117.0
TLS3_k127_719334_8 Protein of unknown function (DUF433) - - - 0.0000000000000005779 83.0
TLS3_k127_7227302_0 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000001154 262.0
TLS3_k127_7227302_1 Cytochrome c - - - 0.00000000000000002039 89.0
TLS3_k127_7238556_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 334.0
TLS3_k127_7238556_1 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000009219 236.0
TLS3_k127_7238556_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000008316 222.0
TLS3_k127_7238556_3 DNA-templated transcription, initiation K03088 - - 0.000000000000000000005813 100.0
TLS3_k127_7248103_0 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 402.0
TLS3_k127_7248103_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000792 115.0
TLS3_k127_7248103_2 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.000001807 58.0
TLS3_k127_7248437_0 beta-lactamase - - - 8.16e-259 822.0
TLS3_k127_7248437_1 COG0147 Anthranilate para-aminobenzoate synthases component I K01665,K03342,K13950 - 2.6.1.85,4.1.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 552.0
TLS3_k127_7248437_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 439.0
TLS3_k127_7248437_3 symporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 383.0
TLS3_k127_7248437_4 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007654 277.0
TLS3_k127_7248437_5 LysR substrate binding domain K21703 - - 0.00000000000000000000000000000000000000633 157.0
TLS3_k127_7248437_6 BadF BadG BcrA BcrD - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000001277 157.0
TLS3_k127_7260950_0 Prolyl oligopeptidase family - - - 9.255e-265 838.0
TLS3_k127_7260950_1 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 353.0
TLS3_k127_7265784_0 cellulose binding - - - 0.0 1569.0
TLS3_k127_7265784_1 Glycoside Hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007655 574.0
TLS3_k127_7265784_2 Glycosyl hydrolases family 16 K01216 - 3.2.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 372.0
TLS3_k127_7265784_3 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.0000000000000000001697 89.0
TLS3_k127_7275026_0 FecR protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 494.0
TLS3_k127_7275026_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 431.0
TLS3_k127_7275026_2 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 420.0
TLS3_k127_7275026_3 - - - - 0.00000000000000000000000000000000000000000000000000000000007722 214.0
TLS3_k127_7275026_4 Transcriptional repressor, CopY family - - - 0.000000000000000000000000000000000000000641 151.0
TLS3_k127_7275026_5 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000004944 149.0
TLS3_k127_7275026_7 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000006705 57.0
TLS3_k127_7275026_8 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.00000001396 66.0
TLS3_k127_7275026_9 - - - - 0.000127 51.0
TLS3_k127_7277333_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.466e-253 805.0
TLS3_k127_7277333_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.863e-224 702.0
TLS3_k127_7277333_10 PFAM regulatory protein GntR HTH K07979 - - 0.00000008262 57.0
TLS3_k127_7277333_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 539.0
TLS3_k127_7277333_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008088 477.0
TLS3_k127_7277333_4 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 398.0
TLS3_k127_7277333_5 glutamine-fructose-6-phosphate transaminase (isomerizing) activity K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 377.0
TLS3_k127_7277333_6 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 303.0
TLS3_k127_7277333_7 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000002722 246.0
TLS3_k127_7277333_8 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000004808 196.0
TLS3_k127_7277333_9 - - - - 0.00000000000000000000000000000000000003345 148.0
TLS3_k127_7291904_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 466.0
TLS3_k127_7291904_1 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 388.0
TLS3_k127_7291904_10 peptidyl-tyrosine sulfation - - - 0.0000008208 61.0
TLS3_k127_7291904_2 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002181 266.0
TLS3_k127_7291904_3 Type II secretory pathway, component ExeA K02450 - - 0.000000000000000000000000000000000000000000000000000000000000002983 228.0
TLS3_k127_7291904_4 eight transmembrane protein EpsH - - - 0.000000000000000000000000000000000000000000000000000000000000009986 228.0
TLS3_k127_7291904_5 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000004001 188.0
TLS3_k127_7291904_6 ATP hydrolysis coupled proton transport K02123 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000003346 154.0
TLS3_k127_7291904_7 Capsular exopolysaccharide family K08252 - 2.7.10.1 0.000000000000000000000000000000000000004288 159.0
TLS3_k127_7291904_8 Chain length determinant protein - - - 0.00000000000000000000000000000001409 144.0
TLS3_k127_7291904_9 PFAM Polysaccharide export protein K01991 - - 0.00000000000000000327 95.0
TLS3_k127_7301145_0 ThiC-associated domain K03147 - 4.1.99.17 1.605e-305 948.0
TLS3_k127_7301145_1 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 611.0
TLS3_k127_7301145_10 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000004522 173.0
TLS3_k127_7301145_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000001308 169.0
TLS3_k127_7301145_12 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000008345 135.0
TLS3_k127_7301145_13 Anti-sigma-K factor rskA - - - 0.000000000000000000008496 102.0
TLS3_k127_7301145_14 Domain of unknown function (DUF4440) - - - 0.0007176 49.0
TLS3_k127_7301145_2 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 551.0
TLS3_k127_7301145_3 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 500.0
TLS3_k127_7301145_4 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 509.0
TLS3_k127_7301145_5 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 509.0
TLS3_k127_7301145_6 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 366.0
TLS3_k127_7301145_7 4Fe-4S double cluster binding domain K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 334.0
TLS3_k127_7301145_8 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000342 256.0
TLS3_k127_7301145_9 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000005593 210.0
TLS3_k127_7372914_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1437.0
TLS3_k127_7372914_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 617.0
TLS3_k127_7372914_10 serine-type endopeptidase activity K07261 - - 0.000000000000000000000000000000003716 138.0
TLS3_k127_7372914_11 TIGRFAM DNA binding domain protein, excisionase family K22491 - - 0.00000000000000000003292 101.0
TLS3_k127_7372914_12 Peptidoglycan-binding domain 1 protein K07260 - 3.4.17.14 0.00000000000000000005467 102.0
TLS3_k127_7372914_13 Universal stress protein - - - 0.0000000000000000008771 97.0
TLS3_k127_7372914_14 Peptidoglycan-binding domain 1 protein K07260 - 3.4.17.14 0.000000000000000001368 95.0
TLS3_k127_7372914_15 peptidoglycan-binding domain-containing protein - - - 0.000000000000001002 90.0
TLS3_k127_7372914_16 - - - - 0.000000000000004775 87.0
TLS3_k127_7372914_18 Rhodanese Homology Domain - - - 0.00000000007369 67.0
TLS3_k127_7372914_19 Protein of unknown function (DUF445) - - - 0.0000000258 64.0
TLS3_k127_7372914_2 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 511.0
TLS3_k127_7372914_3 PFAM sigma-54 factor interaction domain-containing protein K10941 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 477.0
TLS3_k127_7372914_4 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 445.0
TLS3_k127_7372914_5 transposase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 428.0
TLS3_k127_7372914_6 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 383.0
TLS3_k127_7372914_7 8-amino-7-oxononanoate synthase activity K00652 - 2.3.1.47 0.0000000000000000000000000000000000000000000000000000000001424 210.0
TLS3_k127_7372914_8 Lipocalin-like domain K03098 - - 0.000000000000000000000000000000000000000000000001643 181.0
TLS3_k127_7372914_9 COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.000000000000000000000000000000000000000000000006615 178.0
TLS3_k127_7391022_0 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0 1152.0
TLS3_k127_7391022_1 Domain of unknown function (DUF4157) - - - 1.234e-229 737.0
TLS3_k127_7391022_2 ATPase family associated with various cellular activities (AAA) - - - 3.995e-215 689.0
TLS3_k127_7391022_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002125 241.0
TLS3_k127_7416594_0 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 361.0
TLS3_k127_7416594_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000408 215.0
TLS3_k127_7416594_2 PFAM Magnesium chelatase, ChlI subunit K07391 - - 0.000000000000000000000000000000000000000000000000007211 184.0
TLS3_k127_7416594_3 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000006897 155.0
TLS3_k127_7416594_4 - - - - 0.0000000000000001923 89.0
TLS3_k127_7416594_5 Periplasmic or secreted lipoprotein - - - 0.000000000002118 80.0
TLS3_k127_7416594_6 Putative adhesin - - - 0.000000172 61.0
TLS3_k127_7416594_7 Putative zinc-finger - - - 0.0001093 52.0
TLS3_k127_742390_0 alginic acid biosynthetic process - - - 0.000000000000000000000009672 118.0
TLS3_k127_742390_1 COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - 0.000000000000000001109 95.0
TLS3_k127_742390_2 Phage integrase, N-terminal SAM-like domain K14059 - - 0.00000000002681 72.0
TLS3_k127_7435155_0 Protease prsW family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007656 306.0
TLS3_k127_7435155_1 Oxidoreductase activity. It is involved in the biological process described with metabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001658 278.0
TLS3_k127_7435155_2 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.00000000000000000000000000000000000000000000000005541 187.0
TLS3_k127_7435155_3 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000006833 120.0
TLS3_k127_7435155_4 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000002883 115.0
TLS3_k127_7435155_5 Polysaccharide biosynthesis/export protein - - - 0.000000000005968 76.0
TLS3_k127_7453713_0 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 531.0
TLS3_k127_7453713_1 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 417.0
TLS3_k127_7453713_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 415.0
TLS3_k127_7453713_3 Putative glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 433.0
TLS3_k127_7453713_4 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 394.0
TLS3_k127_7453713_5 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002897 272.0
TLS3_k127_7453713_6 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000001184 243.0
TLS3_k127_7453713_7 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000003533 173.0
TLS3_k127_7453713_8 Transglutaminase-like superfamily - - - 0.00000000003722 78.0
TLS3_k127_7453713_9 Papain-like cysteine protease AvrRpt2 - - - 0.00003416 59.0
TLS3_k127_7538648_0 Vault protein inter-alpha-trypsin domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 587.0
TLS3_k127_7538648_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000002653 181.0
TLS3_k127_7538648_2 Alpha-amylase domain K01182 - 3.2.1.10 0.00000000138 70.0
TLS3_k127_7544190_0 belongs to the aldehyde dehydrogenase family K00128,K00154,K22445 - 1.2.1.3,1.2.1.68,1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 593.0
TLS3_k127_7544190_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 521.0
TLS3_k127_7544190_2 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 513.0
TLS3_k127_7544190_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 474.0
TLS3_k127_7544190_4 transcription factor binding K15836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 445.0
TLS3_k127_7544190_5 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004171 441.0
TLS3_k127_7544190_6 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 329.0
TLS3_k127_7544190_7 Putative MetA-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000005915 163.0
TLS3_k127_7544190_8 Antibiotic biosynthesis monooxygenase - - - 0.00000000000001651 79.0
TLS3_k127_7560880_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 1.899e-252 798.0
TLS3_k127_7560880_1 Vault protein inter-alpha-trypsin domain K07114 - - 8.213e-212 677.0
TLS3_k127_7560880_11 - - - - 0.000000000000000000000000000244 124.0
TLS3_k127_7560880_12 Tetratricopeptide repeat - - - 0.000792 50.0
TLS3_k127_7560880_2 Purple acid Phosphatase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 562.0
TLS3_k127_7560880_3 Prolyl oligopeptidase family K00433 - 1.11.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 501.0
TLS3_k127_7560880_4 Belongs to the proline racemase family K01777 - 5.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 425.0
TLS3_k127_7560880_5 N,N-dimethylaniline monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 417.0
TLS3_k127_7560880_7 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000007194 216.0
TLS3_k127_7560880_8 Cellulase (glycosyl hydrolase family 5) K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000002654 181.0
TLS3_k127_7560880_9 - - - - 0.000000000000000000000000000000000000000004341 162.0
TLS3_k127_7575078_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0 1040.0
TLS3_k127_7575078_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 3.27e-286 902.0
TLS3_k127_7575078_10 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 415.0
TLS3_k127_7575078_11 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007009 375.0
TLS3_k127_7575078_12 PFAM Integral membrane protein TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 366.0
TLS3_k127_7575078_13 Chaperone of endosialidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 320.0
TLS3_k127_7575078_14 PFAM Peptidase M19, renal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 306.0
TLS3_k127_7575078_15 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002984 289.0
TLS3_k127_7575078_16 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000001751 239.0
TLS3_k127_7575078_17 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000001053 198.0
TLS3_k127_7575078_18 O-Antigen ligase K02847 - - 0.000000000000000000000000000000000000002962 164.0
TLS3_k127_7575078_19 Peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000004934 163.0
TLS3_k127_7575078_2 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 6.858e-251 784.0
TLS3_k127_7575078_20 - - - - 0.000000000000000000000000000000007369 145.0
TLS3_k127_7575078_21 PQQ enzyme repeat - - - 0.0000000000000000000000000001148 129.0
TLS3_k127_7575078_22 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000005671 123.0
TLS3_k127_7575078_23 Chaperone of endosialidase - - - 0.00000003586 66.0
TLS3_k127_7575078_24 Tetratricopeptide TPR_2 repeat protein - - - 0.00000004635 65.0
TLS3_k127_7575078_25 Archaeal Type IV pilin, N-terminal - - - 0.0000009743 60.0
TLS3_k127_7575078_26 antisigma factor binding K03598 - - 0.0002903 52.0
TLS3_k127_7575078_3 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 2.86e-206 654.0
TLS3_k127_7575078_4 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 613.0
TLS3_k127_7575078_5 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007402 511.0
TLS3_k127_7575078_6 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 481.0
TLS3_k127_7575078_7 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 464.0
TLS3_k127_7575078_8 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005962 458.0
TLS3_k127_7575078_9 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 409.0
TLS3_k127_762451_0 Succinyl-CoA ligase like flavodoxin domain - - - 1.27e-309 974.0
TLS3_k127_7632122_0 FtsX-like permease family - - - 3.339e-219 720.0
TLS3_k127_7632122_1 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 296.0
TLS3_k127_7632122_2 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008897 254.0
TLS3_k127_7632122_3 Tetratricopeptide repeat K09527 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0030544,GO:0031072,GO:0051084,GO:0051085,GO:0061077 - 0.00000000002833 71.0
TLS3_k127_7632122_4 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000001262 55.0
TLS3_k127_7636237_0 Phosphoesterase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007721 288.0
TLS3_k127_7636237_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000001285 186.0
TLS3_k127_7636237_2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - - 0.000000000000000000000000000000000000000001285 166.0
TLS3_k127_7636237_3 PFAM Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000289 165.0
TLS3_k127_7636237_4 LGFP repeat - - - 0.00000000000000000000005915 117.0
TLS3_k127_7636237_5 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - - 0.000000000000000004783 96.0
TLS3_k127_7636237_6 Pkd domain containing protein K12567 - 2.7.11.1 0.000000000000000006143 100.0
TLS3_k127_7636237_7 PFAM PKD domain containing protein - - - 0.000000000007323 78.0
TLS3_k127_7636237_8 cell adhesion K02024 - - 0.000000003191 72.0
TLS3_k127_7636237_9 Endonuclease/Exonuclease/phosphatase family - - - 0.00000002576 66.0
TLS3_k127_7666755_0 PFAM Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 629.0
TLS3_k127_7666755_1 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 544.0
TLS3_k127_7666755_10 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07658 - - 0.00000000000000001195 88.0
TLS3_k127_7666755_2 Ribonuclease HII K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 383.0
TLS3_k127_7666755_3 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 334.0
TLS3_k127_7666755_4 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000006173 226.0
TLS3_k127_7666755_5 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000008036 205.0
TLS3_k127_7666755_6 Transcriptional regulator, Crp Fnr family - - - 0.000000000000000000000000000000000000000000000000001662 192.0
TLS3_k127_7666755_7 - - - - 0.0000000000000000000000000000000000000000000000001303 192.0
TLS3_k127_7666755_8 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000002681 159.0
TLS3_k127_7666755_9 von Willebrand factor, type A K07114 - - 0.000000000000000000000000007118 124.0
TLS3_k127_7666816_0 cell shape determining protein MreB K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 504.0
TLS3_k127_7666816_1 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 312.0
TLS3_k127_7666816_2 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000006818 198.0
TLS3_k127_7666816_3 Pkd domain containing protein - - - 0.000000000000000000000000000000000001102 153.0
TLS3_k127_7666816_4 Cro/C1-type HTH DNA-binding domain - - - 0.0006441 47.0
TLS3_k127_7679966_0 Zinc-binding dehydrogenase - - - 1.847e-291 911.0
TLS3_k127_7679966_1 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 369.0
TLS3_k127_7679966_2 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 325.0
TLS3_k127_7679966_3 transferase activity, transferring glycosyl groups K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 314.0
TLS3_k127_7679966_4 TIGRFAM polysaccharide deactylase family protein, PEP-CTERM locus subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 300.0
TLS3_k127_7679966_5 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000002993 171.0
TLS3_k127_7679966_6 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.00000000000000000000000000000000000000006365 169.0
TLS3_k127_7679966_7 methyltransferase - - - 0.000000000000000000000000001606 120.0
TLS3_k127_7679966_8 O-Antigen ligase - - - 0.0000002337 63.0
TLS3_k127_77376_0 Uncharacterized conserved protein (DUF2075) - - - 8.897e-274 856.0
TLS3_k127_77376_1 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 448.0
TLS3_k127_77376_2 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000237 153.0
TLS3_k127_77376_3 Polysaccharide deacetylase K01452,K14659,K22278 - 3.5.1.104,3.5.1.41 0.000000000000000001224 94.0
TLS3_k127_77376_4 - - - - 0.00000000000001783 79.0
TLS3_k127_7796480_0 Carboxypeptidase regulatory-like domain - - - 1.492e-251 815.0
TLS3_k127_7796480_1 Phosphate acyltransferases K00655,K01897 - 2.3.1.51,6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 547.0
TLS3_k127_7796480_2 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000006336 143.0
TLS3_k127_7796480_3 Universal stress protein family - - - 0.0000000000000000000000000000001027 136.0
TLS3_k127_7796480_4 Universal stress protein family - - - 0.0000000000000000000000001481 112.0
TLS3_k127_7796480_5 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000123 106.0
TLS3_k127_7798258_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1102.0
TLS3_k127_7798258_1 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 442.0
TLS3_k127_7798258_2 MgtE intracellular N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008656 429.0
TLS3_k127_7798258_3 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000008711 225.0
TLS3_k127_7798258_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000298 161.0
TLS3_k127_7798258_5 Tricorn protease C1 domain K03797 - 3.4.21.102 0.000000000000000000000000000000000000007331 162.0
TLS3_k127_7798258_6 Hsp20/alpha crystallin family K13993 - - 0.000000000000000000000000001689 116.0
TLS3_k127_7798258_7 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0001331 52.0
TLS3_k127_7834083_0 alpha-L-arabinofuranosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 489.0
TLS3_k127_7834083_1 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000005497 253.0
TLS3_k127_7834083_2 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000000005107 203.0
TLS3_k127_7834083_3 glycosyl hydrolase, BNR repeat-containing protein - - - 0.00000000000000000000000155 123.0
TLS3_k127_7834083_5 Ankyrin repeat - - - 0.0000003538 61.0
TLS3_k127_7855165_0 RQC K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 517.0
TLS3_k127_7855165_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335,K18331 - 1.12.1.3,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 503.0
TLS3_k127_7855165_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000001731 152.0
TLS3_k127_7855165_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000002241 126.0
TLS3_k127_7855165_12 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000003688 117.0
TLS3_k127_7855165_13 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000002822 74.0
TLS3_k127_7855165_14 - - - - 0.000000000001211 78.0
TLS3_k127_7855165_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 490.0
TLS3_k127_7855165_3 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 473.0
TLS3_k127_7855165_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 358.0
TLS3_k127_7855165_5 thiamine diphosphate biosynthetic process K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 345.0
TLS3_k127_7855165_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000654 248.0
TLS3_k127_7855165_7 endonuclease exonuclease phosphatase K07004 - - 0.0000000000000000000000000000000000000000000000000000009666 206.0
TLS3_k127_7855165_8 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000002764 189.0
TLS3_k127_7855165_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000003877 166.0
TLS3_k127_7855297_0 cellulose binding - - - 0.0 1049.0
TLS3_k127_7855297_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007143 513.0
TLS3_k127_7855297_10 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002597 290.0
TLS3_k127_7855297_11 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002591 270.0
TLS3_k127_7855297_12 Domain of unknown function (DUF3488) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007161 274.0
TLS3_k127_7855297_13 Uracil DNA glycosylase superfamily K01934,K03649 GO:0000700,GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008263,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.28,6.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000001044 249.0
TLS3_k127_7855297_14 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000005009 222.0
TLS3_k127_7855297_15 oxidoreductase activity - - - 0.00000000000000000000000000000000000002432 165.0
TLS3_k127_7855297_16 PFAM Adenylate cyclase K05873 - 4.6.1.1 0.0000000000000000000000006841 110.0
TLS3_k127_7855297_17 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000001106 107.0
TLS3_k127_7855297_18 Response regulator receiver - - - 0.00000000000000000000003184 104.0
TLS3_k127_7855297_19 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.0000000000000000308 84.0
TLS3_k127_7855297_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 447.0
TLS3_k127_7855297_20 Putative adhesin - - - 0.000629 51.0
TLS3_k127_7855297_3 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 409.0
TLS3_k127_7855297_4 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 401.0
TLS3_k127_7855297_5 Hydrolase Family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 336.0
TLS3_k127_7855297_6 Peptidogalycan biosysnthesis/recognition K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 335.0
TLS3_k127_7855297_7 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 307.0
TLS3_k127_7855297_8 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 295.0
TLS3_k127_7855297_9 PFAM Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002117 282.0
TLS3_k127_7870871_0 Cation transport regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000004933 235.0
TLS3_k127_7870871_1 IstB-like ATP binding protein K02315 - - 0.000000000000000000000000000000000000000000000000000003239 199.0
TLS3_k127_7870871_2 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.0000000000000002151 82.0
TLS3_k127_7870871_3 Belongs to the CarB family K01955 - 6.3.5.5 0.0000000005986 61.0
TLS3_k127_7873866_0 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 3.816e-204 663.0
TLS3_k127_7873866_1 Alcohol dehydrogenase GroES-like domain K00148 - 1.2.1.46 0.000000000000000000000000000000000000000000000001883 175.0
TLS3_k127_7886493_0 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 612.0
TLS3_k127_7886493_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 552.0
TLS3_k127_7886493_10 Ankyrin repeat-containing protein K21440 - - 0.000000000002955 76.0
TLS3_k127_7886493_11 - - - - 0.0000002551 59.0
TLS3_k127_7886493_2 COG0635 Coproporphyrinogen III oxidase and related Fe-S - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 506.0
TLS3_k127_7886493_3 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 481.0
TLS3_k127_7886493_4 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 424.0
TLS3_k127_7886493_5 COG0644 Dehydrogenases (flavoproteins) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 421.0
TLS3_k127_7886493_6 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007121 362.0
TLS3_k127_7886493_7 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 347.0
TLS3_k127_7886493_8 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 337.0
TLS3_k127_7886493_9 - - - - 0.0000000000000000000006139 105.0
TLS3_k127_7895400_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 476.0
TLS3_k127_7895400_1 eRF1 domain 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006681 404.0
TLS3_k127_7895400_2 Trypsin-like serine protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005671 281.0
TLS3_k127_7895400_3 - - - - 0.00000000000000000000000000000000000000000000000000000000003889 211.0
TLS3_k127_7895400_4 domain protein K14194 - - 0.00000000000000000005522 104.0
TLS3_k127_7895400_5 histone H2A K63-linked ubiquitination K08884,K11894 - 2.7.11.1 0.00000000000004208 86.0
TLS3_k127_7895400_6 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.0000000000002695 73.0
TLS3_k127_7895400_7 domain protein K14194 - - 0.000000000001511 81.0
TLS3_k127_7895400_8 Two component transcriptional regulator, winged helix family - - - 0.0000000002473 66.0
TLS3_k127_7895435_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008783 350.0
TLS3_k127_7895435_1 Protein of unknown function (DUF1203) - - - 0.00000000000000000000000000000000000000000000000000005653 192.0
TLS3_k127_7895435_2 TIGRFAM thioredoxin K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000000000672 173.0
TLS3_k127_7895435_3 DinB family - - - 0.00000000000000002572 88.0
TLS3_k127_7920673_0 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000002356 152.0
TLS3_k127_7920673_1 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000002994 159.0
TLS3_k127_7920673_2 Sigma-54 interaction domain K07714 - - 0.00000000000008405 79.0
TLS3_k127_7920673_3 domain, Protein - - - 0.00000002977 67.0
TLS3_k127_7973611_0 PFAM Prolyl oligopeptidase family - - - 3.282e-277 865.0
TLS3_k127_7973611_1 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 545.0
TLS3_k127_7973611_2 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 348.0
TLS3_k127_7973611_3 double-stranded DNA 3'-5' exodeoxyribonuclease activity K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008129 299.0
TLS3_k127_7973611_4 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000457 254.0
TLS3_k127_7973611_5 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000006853 243.0
TLS3_k127_7973611_6 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000008346 204.0
TLS3_k127_7973611_7 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000000007295 124.0
TLS3_k127_7973611_9 - - - - 0.000000000000000000007085 99.0
TLS3_k127_7981141_0 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 1.776e-316 981.0
TLS3_k127_7981141_1 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003302 246.0
TLS3_k127_7981141_2 COG0492 Thioredoxin reductase K00384 - 1.8.1.9 0.0005997 43.0
TLS3_k127_8000584_0 Carboxypeptidase regulatory-like domain - - - 2.087e-232 755.0
TLS3_k127_8000584_1 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 616.0
TLS3_k127_8000584_2 K+ potassium transporter K03549 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007631 284.0
TLS3_k127_8000584_3 NAD+ binding - - - 0.0000000004807 61.0
TLS3_k127_8000584_4 - - - - 0.0000009989 58.0
TLS3_k127_8001417_0 serine-type peptidase activity - - - 0.0 1084.0
TLS3_k127_8001417_1 Peptidase family M3 K01284 - 3.4.15.5 0.0 1064.0
TLS3_k127_8001417_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 414.0
TLS3_k127_8001417_11 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 416.0
TLS3_k127_8001417_12 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 405.0
TLS3_k127_8001417_13 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004982 401.0
TLS3_k127_8001417_14 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 400.0
TLS3_k127_8001417_15 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009686 365.0
TLS3_k127_8001417_16 Cys Met metabolism K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 360.0
TLS3_k127_8001417_17 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 352.0
TLS3_k127_8001417_18 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 308.0
TLS3_k127_8001417_19 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001013 284.0
TLS3_k127_8001417_2 hydrolase family 92 - - - 2.862e-316 996.0
TLS3_k127_8001417_20 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000006986 267.0
TLS3_k127_8001417_21 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005215 257.0
TLS3_k127_8001417_22 histidine kinase internal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007351 257.0
TLS3_k127_8001417_23 Belongs to the BI1 family K06890 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000001619 214.0
TLS3_k127_8001417_24 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000004291 200.0
TLS3_k127_8001417_25 beta-fructofuranosidase activity - - - 0.00000000000000000000000000000000000000000000000000004768 209.0
TLS3_k127_8001417_26 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000004972 179.0
TLS3_k127_8001417_27 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000001679 181.0
TLS3_k127_8001417_28 JAB/MPN domain - - - 0.00000000000000000000000000000000000000007303 158.0
TLS3_k127_8001417_29 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000002993 127.0
TLS3_k127_8001417_3 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.701e-309 987.0
TLS3_k127_8001417_30 Peptidylprolyl isomerase K03771 - 5.2.1.8 0.0000000000000000000000000009657 126.0
TLS3_k127_8001417_31 Predicted membrane protein (DUF2085) - - - 0.000000000000000000000000576 112.0
TLS3_k127_8001417_32 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.0000000000000000000004997 100.0
TLS3_k127_8001417_33 - - - - 0.00000000000000002305 91.0
TLS3_k127_8001417_34 - - - - 0.0000000000000006732 80.0
TLS3_k127_8001417_35 helix_turn_helix, arabinose operon control protein - - - 0.000000000000001124 82.0
TLS3_k127_8001417_36 ErfK YbiS YcfS YnhG - - - 0.0000000000008126 81.0
TLS3_k127_8001417_37 SpoVT / AbrB like domain - - - 0.000000005697 61.0
TLS3_k127_8001417_38 - - - - 0.00000001948 66.0
TLS3_k127_8001417_39 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00001816 57.0
TLS3_k127_8001417_4 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.527e-255 806.0
TLS3_k127_8001417_5 ThiS family K21029,K21147 - 2.7.7.80,2.8.1.11 5.414e-194 616.0
TLS3_k127_8001417_6 Acyl-CoA dehydrogenase, C-terminal domain K16173 - 1.3.99.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 516.0
TLS3_k127_8001417_7 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005199 522.0
TLS3_k127_8001417_8 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008061 504.0
TLS3_k127_8001417_9 glycyl-tRNA aminoacylation K01880 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 499.0
TLS3_k127_8065870_0 cell shape determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 551.0
TLS3_k127_8065870_1 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 385.0
TLS3_k127_8065870_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000002849 245.0
TLS3_k127_8065870_3 GAF domain - - - 0.000000000000000000000000000000000000000002681 174.0
TLS3_k127_8065870_4 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000001555 132.0
TLS3_k127_8065870_5 shape-determining protein MreD K03571 - - 0.000005968 55.0
TLS3_k127_8065870_6 FecR protein - - - 0.00009995 54.0
TLS3_k127_8077469_0 TROVE domain - - - 5.139e-211 667.0
TLS3_k127_8077469_1 Integrase core domain K07497 - - 0.00000000000000000000000000000000000000000000000000000000007868 209.0
TLS3_k127_8077469_2 RES - - - 0.00000000000000000000000000000000000001218 149.0
TLS3_k127_8077469_3 Transposase K07497 - - 0.0000000000000000000000000000000000006349 140.0
TLS3_k127_8077469_4 Protein of unknown function (DUF2384) - - - 0.000000000000000000000000005331 115.0
TLS3_k127_8077469_5 - - - - 0.00000000000000000001116 96.0
TLS3_k127_8088239_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 7.046e-221 696.0
TLS3_k127_8088239_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 1.303e-199 635.0
TLS3_k127_8088239_10 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 329.0
TLS3_k127_8088239_11 von Willebrand factor (vWF) type A domain K02448 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 324.0
TLS3_k127_8088239_12 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 303.0
TLS3_k127_8088239_13 with different specificities (related to short-chain alcohol K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002312 278.0
TLS3_k127_8088239_14 protein conserved in bacteria K09974 - - 0.0000000000000000000000000000000000000000000000000002715 192.0
TLS3_k127_8088239_15 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner K03687 - - 0.000000000000000002162 93.0
TLS3_k127_8088239_16 - - - - 0.00000000006302 72.0
TLS3_k127_8088239_2 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 596.0
TLS3_k127_8088239_3 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 592.0
TLS3_k127_8088239_4 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 515.0
TLS3_k127_8088239_5 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 479.0
TLS3_k127_8088239_6 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 417.0
TLS3_k127_8088239_7 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 417.0
TLS3_k127_8088239_8 CbbQ/NirQ/NorQ C-terminal K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 371.0
TLS3_k127_8088239_9 Ankyrin repeats (many copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 369.0
TLS3_k127_8093077_0 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006641 390.0
TLS3_k127_8093077_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000009766 218.0
TLS3_k127_8093077_2 Acyl-transferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000002183 189.0
TLS3_k127_8093077_3 - - - - 0.0000000000000000000000000000000000000001175 159.0
TLS3_k127_8093077_4 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000005654 155.0
TLS3_k127_8093077_5 - - - - 0.000000000000000000000000000000000002553 141.0
TLS3_k127_8093077_6 Diguanylate cyclase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000001301 126.0
TLS3_k127_8093077_7 DinB family - - - 0.0000000000000000000000000000136 124.0
TLS3_k127_8093077_8 PFAM CHAD domain - - - 0.0000000000000000000006058 107.0
TLS3_k127_8113475_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 332.0
TLS3_k127_8113475_1 Belongs to the sulfur carrier protein TusA family - - - 0.000005039 57.0
TLS3_k127_8113475_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0001908 55.0
TLS3_k127_8113475_3 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0003703 43.0
TLS3_k127_8258720_0 Multicopper oxidase - - - 0.0 1781.0
TLS3_k127_8258720_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 547.0
TLS3_k127_8258720_10 PFAM Tetratricopeptide repeat - - - 0.00005204 55.0
TLS3_k127_8258720_2 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 446.0
TLS3_k127_8258720_3 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 415.0
TLS3_k127_8258720_4 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 394.0
TLS3_k127_8258720_5 SCO1/SenC K07152,K08976 - - 0.0000000000000000000000000000000000000000000000000000000000002872 217.0
TLS3_k127_8258720_6 SCO1/SenC K07152,K08976 - - 0.00000000000000000000000000000000000000000000000000000006255 206.0
TLS3_k127_8258720_7 Protein of unknown function (DUF3455) - - - 0.00000000000000000000000004342 115.0
TLS3_k127_8258720_8 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000009636 100.0
TLS3_k127_8258720_9 ankyrin repeat K06867 - - 0.00000000001327 76.0
TLS3_k127_8261885_0 phosphorylase K00688 - 2.4.1.1 5.343e-245 776.0
TLS3_k127_8261885_1 Leucine-rich repeat K13730 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 370.0
TLS3_k127_8261885_2 Appr-1'-p processing enzyme - - - 0.000000000000000000000000000000000000000000000000000000004388 204.0
TLS3_k127_8261885_3 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000003682 210.0
TLS3_k127_8261885_4 Domain of unknown function (DUF4384) - - - 0.000000000000001116 87.0
TLS3_k127_8275408_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 402.0
TLS3_k127_8275408_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000005619 149.0
TLS3_k127_8275408_3 - - - - 0.00000546 48.0
TLS3_k127_8287882_0 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008599 533.0
TLS3_k127_8287882_1 protein kinase related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 520.0
TLS3_k127_8287882_2 Iron-containing alcohol dehydrogenase K00001,K13954 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 410.0
TLS3_k127_8287882_3 Sigma-54 interaction domain K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 351.0
TLS3_k127_8287882_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 334.0
TLS3_k127_8287882_5 protein kinase related protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 301.0
TLS3_k127_8287882_6 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000003558 209.0
TLS3_k127_8287882_7 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000008294 137.0
TLS3_k127_8287882_8 Protein of unknown function (DUF3311) - - - 0.000000000000008905 76.0
TLS3_k127_8287882_9 beta-propeller repeat - - - 0.0002224 46.0
TLS3_k127_8289009_0 Horizontally Transferred TransMembrane Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 494.0
TLS3_k127_8289009_1 Protein of unknown function (DUF4256) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 309.0
TLS3_k127_8289009_2 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000195 131.0
TLS3_k127_8289009_3 agmatine deiminase activity K10536 - 3.5.3.12 0.000008054 52.0
TLS3_k127_8295908_0 PFAM DNA mismatch repair protein MutS domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 498.0
TLS3_k127_8295908_1 PFAM aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.0000000000000011 83.0
TLS3_k127_8456502_0 Cytochrome c - - - 5.981e-303 967.0
TLS3_k127_8456502_1 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 1.287e-195 628.0
TLS3_k127_8456502_10 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000009622 194.0
TLS3_k127_8456502_11 heme a metabolic process K02259,K03110 - - 0.00000000000000000000000000000000000000001104 165.0
TLS3_k127_8456502_12 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000001025 149.0
TLS3_k127_8456502_13 cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.00000000000000000000000008536 115.0
TLS3_k127_8456502_15 Glutaredoxin - - - 0.0000000000002225 74.0
TLS3_k127_8456502_2 TIGRFAM magnesium chelatase, H subunit K03403 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 531.0
TLS3_k127_8456502_3 TIGRFAM magnesium chelatase, H subunit K03403 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 534.0
TLS3_k127_8456502_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 467.0
TLS3_k127_8456502_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 434.0
TLS3_k127_8456502_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 308.0
TLS3_k127_8456502_7 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000003392 252.0
TLS3_k127_8456502_8 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.000000000000000000000000000000000000000000000000000000000000000001559 232.0
TLS3_k127_8456502_9 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000001676 230.0
TLS3_k127_8498118_0 radical SAM domain protein - - - 1.764e-293 910.0
TLS3_k127_8498118_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 598.0
TLS3_k127_8498118_10 peptidase inhibitor activity - - - 0.000000000000000000005976 104.0
TLS3_k127_8498118_11 RESPONSE REGULATOR receiver - - - 0.0000000004778 65.0
TLS3_k127_8498118_12 Endonuclease Exonuclease Phosphatase - - - 0.0000000242 65.0
TLS3_k127_8498118_2 tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 532.0
TLS3_k127_8498118_3 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 463.0
TLS3_k127_8498118_4 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 290.0
TLS3_k127_8498118_5 Alpha beta hydrolase K00433 - 1.11.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000146 264.0
TLS3_k127_8498118_6 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000000000022 190.0
TLS3_k127_8498118_7 DinB superfamily - - - 0.000000000000000000000000000000000000000000002668 173.0
TLS3_k127_8498118_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000001204 167.0
TLS3_k127_8498118_9 oxidation-reduction process K09022 - 3.5.99.10 0.0000000000000000000000000000000000000004319 153.0
TLS3_k127_8527020_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1561.0
TLS3_k127_8527020_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K01719,K13542 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,4.1.1.37,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 468.0
TLS3_k127_8527020_2 protoporphyrinogen oxidase activity K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 451.0
TLS3_k127_8527020_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 443.0
TLS3_k127_8527020_4 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 377.0
TLS3_k127_8527020_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007454 376.0
TLS3_k127_8527020_6 Spermine/spermidine synthase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005907 368.0
TLS3_k127_8527020_7 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000001427 228.0
TLS3_k127_8527020_8 - - - - 0.0000000000000000000000000000000000001502 145.0
TLS3_k127_8527020_9 Pfam:N_methyl_2 - - - 0.0000007594 58.0
TLS3_k127_8545976_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1317.0
TLS3_k127_8545976_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.046e-293 923.0
TLS3_k127_8545976_10 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 349.0
TLS3_k127_8545976_11 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 364.0
TLS3_k127_8545976_12 AcrB/AcrD/AcrF family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 322.0
TLS3_k127_8545976_13 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 312.0
TLS3_k127_8545976_14 TOBE domain K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 305.0
TLS3_k127_8545976_15 PepSY-associated TM region K09939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001582 261.0
TLS3_k127_8545976_16 PFAM short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005667 248.0
TLS3_k127_8545976_17 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000003322 226.0
TLS3_k127_8545976_18 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000003683 232.0
TLS3_k127_8545976_19 Scaffold protein Nfu/NifU N terminal - - - 0.00000000000000000000000000000000000000000000000000000005738 202.0
TLS3_k127_8545976_2 Enoyl-CoA hydratase/isomerase K15513 - 4.1.2.44 5.891e-218 688.0
TLS3_k127_8545976_20 Belongs to the glycosyl hydrolase 5 (cellulase A) family K19355 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004567,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010412,GO:0015923,GO:0016052,GO:0016787,GO:0016798,GO:0016985,GO:0016998,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046355,GO:0071554,GO:0071704,GO:1901575 3.2.1.78 0.0000000000000000000000000000000000000000000000000008309 205.0
TLS3_k127_8545976_21 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000002783 184.0
TLS3_k127_8545976_22 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000001568 181.0
TLS3_k127_8545976_23 DinB family - - - 0.00000000000000000000000000000000000000000000009684 175.0
TLS3_k127_8545976_24 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000005663 174.0
TLS3_k127_8545976_25 Bacterial regulatory proteins, tetR family K09017 - - 0.000000000000000000000000000000000172 141.0
TLS3_k127_8545976_26 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000326 73.0
TLS3_k127_8545976_27 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000002197 74.0
TLS3_k127_8545976_28 COG0500 SAM-dependent methyltransferases - - - 0.0000001054 54.0
TLS3_k127_8545976_29 Belongs to the UPF0232 family - - - 0.0000002155 61.0
TLS3_k127_8545976_3 Peptidase family M28 - - - 1.794e-215 685.0
TLS3_k127_8545976_30 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000161 56.0
TLS3_k127_8545976_31 Belongs to the UPF0337 (CsbD) family - - - 0.000002271 54.0
TLS3_k127_8545976_4 benzoyl-CoA oxygenase K15512 - 1.14.13.208 8.102e-213 671.0
TLS3_k127_8545976_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 542.0
TLS3_k127_8545976_6 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 537.0
TLS3_k127_8545976_7 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 409.0
TLS3_k127_8545976_8 glycosyl transferase group 1 K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 396.0
TLS3_k127_8545976_9 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 357.0
TLS3_k127_85815_0 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K20444 - 2.1.1.222,2.1.1.64 1.264e-265 863.0
TLS3_k127_85815_1 Glycosyltransferase like family 2 - - - 4.354e-199 640.0
TLS3_k127_85815_10 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000006425 219.0
TLS3_k127_85815_11 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000005804 198.0
TLS3_k127_85815_12 methyltransferase - - - 0.00000000000000000000000000000000001642 147.0
TLS3_k127_85815_13 Glycosyltransferase like family 2 K12988 - - 0.000000000000000000000000000126 128.0
TLS3_k127_85815_14 Universal stress protein family - - - 0.00000000000000004514 93.0
TLS3_k127_85815_15 ABC-type antimicrobial peptide transport system, permease component - - - 0.00000000002967 66.0
TLS3_k127_85815_16 heme binding K08642 - - 0.0000000002551 67.0
TLS3_k127_85815_17 COG3387 Glucoamylase and related glycosyl hydrolases - - - 0.0000001766 56.0
TLS3_k127_85815_18 Psort location CytoplasmicMembrane, score - - - 0.00003722 57.0
TLS3_k127_85815_2 PFAM NAD dependent epimerase dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008504 501.0
TLS3_k127_85815_3 PFAM ABC transporter related K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 440.0
TLS3_k127_85815_4 COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 396.0
TLS3_k127_85815_5 Mechanosensitive ion channel K05802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 392.0
TLS3_k127_85815_6 COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001906 254.0
TLS3_k127_85815_7 Glycosyltransferase K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000003992 247.0
TLS3_k127_85815_8 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001266 246.0
TLS3_k127_85815_9 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000004933 224.0
TLS3_k127_87701_0 DEAD DEAH box helicase K03724 - - 0.0 1725.0
TLS3_k127_87701_1 metallocarboxypeptidase activity K14054 - - 1.671e-285 909.0
TLS3_k127_87701_10 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000005975 213.0
TLS3_k127_87701_11 Belongs to the UPF0502 family K09915 - - 0.000000000000000000000000000000000000000000000000000000000006311 215.0
TLS3_k127_87701_12 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000000008944 201.0
TLS3_k127_87701_13 EVE domain - - - 0.000000000000000000000000000000000000000000000000455 179.0
TLS3_k127_87701_14 Protein of unknown function (DUF3052) - - - 0.00000000000000000000000000000000009945 144.0
TLS3_k127_87701_15 lactoylglutathione lyase activity K00941,K01724,K01759,K07032,K08234 - 2.7.1.49,2.7.4.7,4.2.1.96,4.4.1.5 0.00000000000000000000002233 104.0
TLS3_k127_87701_2 ABC1 family K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 560.0
TLS3_k127_87701_3 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 461.0
TLS3_k127_87701_4 transporter K03319 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 447.0
TLS3_k127_87701_5 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 407.0
TLS3_k127_87701_6 PFAM DNA photolyase, FAD-binding K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 393.0
TLS3_k127_87701_7 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 335.0
TLS3_k127_87701_8 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 310.0
TLS3_k127_87701_9 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001114 279.0
TLS3_k127_886503_0 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 487.0
TLS3_k127_886503_1 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 397.0
TLS3_k127_886503_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 372.0
TLS3_k127_886503_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 291.0
TLS3_k127_886503_4 Metalloenzyme superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000002662 225.0
TLS3_k127_886503_5 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000000000000000000000000000000000000000000001259 207.0
TLS3_k127_886503_6 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000003412 183.0
TLS3_k127_886503_7 von Willebrand factor, type A K07114 - - 0.0000000000000000001845 102.0
TLS3_k127_886503_8 - - - - 0.00001758 52.0
TLS3_k127_903980_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1384.0
TLS3_k127_903980_1 ATPase associated with various cellular activities, AAA_5 K02584 - - 7.907e-200 641.0
TLS3_k127_903980_2 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 547.0
TLS3_k127_903980_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004694 340.0
TLS3_k127_903980_4 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000003454 239.0
TLS3_k127_903980_5 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000001302 233.0
TLS3_k127_903980_6 OsmC-like protein - - - 0.000000000000000000000000000000000000000002629 160.0
TLS3_k127_903980_7 DNA-binding transcription factor activity K03892 - - 0.000000000000000000000000000443 117.0
TLS3_k127_903980_8 Protein of unknown function (DUF2892) - - - 0.0000000000000000005202 90.0
TLS3_k127_903980_9 PFAM UspA domain protein K06149 - - 0.0003293 49.0
TLS3_k127_906324_0 Phosphate acyltransferases K01897 - 6.2.1.3 5.51e-230 739.0
TLS3_k127_906324_1 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 612.0
TLS3_k127_906324_2 competence protein COMEC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 446.0
TLS3_k127_906324_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 324.0
TLS3_k127_906324_4 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000582 198.0
TLS3_k127_906324_5 PFAM Calcineurin-like phosphoesterase K01090 - 3.1.3.16 0.0000000000000000000000000005286 113.0
TLS3_k127_937207_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 442.0
TLS3_k127_937207_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 344.0
TLS3_k127_946176_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 550.0
TLS3_k127_946176_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 481.0
TLS3_k127_946176_10 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000217 252.0
TLS3_k127_946176_11 Histidine biosynthesis protein K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000004047 245.0
TLS3_k127_946176_12 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000001004 222.0
TLS3_k127_946176_13 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000003238 191.0
TLS3_k127_946176_14 diguanylate cyclase - - - 0.0000000000000000000000000000000002065 145.0
TLS3_k127_946176_15 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000004992 130.0
TLS3_k127_946176_16 - - - - 0.0001651 44.0
TLS3_k127_946176_2 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 473.0
TLS3_k127_946176_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 440.0
TLS3_k127_946176_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006459 360.0
TLS3_k127_946176_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 309.0
TLS3_k127_946176_6 oxidoreductase activity, acting on CH-OH group of donors K13237 - 1.3.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 297.0
TLS3_k127_946176_7 Inositol monophosphatase family K01092,K05602 - 3.1.3.15,3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 297.0
TLS3_k127_946176_8 Peptidase C26 K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004991 269.0
TLS3_k127_946176_9 belongs to the PRA-CH family K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000001308 260.0
TLS3_k127_951519_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 7.429e-309 965.0
TLS3_k127_951519_1 COG1404 Subtilisin-like serine proteases K09607 - - 9.277e-250 791.0
TLS3_k127_951519_10 TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.00000000000000000000000000000000000001341 150.0
TLS3_k127_951519_11 transcriptional regulator K03655 - 3.6.4.12 0.00000000000000000000000000000001594 142.0
TLS3_k127_951519_12 COGs COG2929 conserved K09803 - - 0.0000000000000000000004974 100.0
TLS3_k127_951519_15 - - - - 0.000000000000007992 87.0
TLS3_k127_951519_16 B-1 B cell differentiation - - - 0.00000000000004275 87.0
TLS3_k127_951519_17 - - - - 0.0000000000002517 74.0
TLS3_k127_951519_18 Belongs to the N(4) N(6)-methyltransferase family K00590 - 2.1.1.113 0.000000000000472 69.0
TLS3_k127_951519_19 - - - - 0.00000000001715 77.0
TLS3_k127_951519_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 606.0
TLS3_k127_951519_20 HNH endonuclease - - - 0.00000161 56.0
TLS3_k127_951519_21 DNA integration K14059 - - 0.000001979 49.0
TLS3_k127_951519_22 Protein conserved in bacteria - - - 0.000004083 57.0
TLS3_k127_951519_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 322.0
TLS3_k127_951519_4 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 320.0
TLS3_k127_951519_5 MOSC N-terminal beta barrel domain K07140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005005 257.0
TLS3_k127_951519_6 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000002026 216.0
TLS3_k127_951519_7 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000000000000001332 212.0
TLS3_k127_951519_8 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000654 183.0
TLS3_k127_951519_9 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.000000000000000000000000000000000000001547 151.0
TLS3_k127_960028_0 thymidine kinase activity K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000003159 228.0
TLS3_k127_960028_1 CHAT domain - - - 0.00000000000000000000000000000000000000001031 173.0
TLS3_k127_960028_2 Protein of unknown function DUF84 - GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564 - 0.00000000000000000000000001161 117.0
TLS3_k127_960028_4 Subtilase family - - - 0.00000001475 67.0
TLS3_k127_965476_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 1.439e-243 767.0
TLS3_k127_965476_1 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 486.0
TLS3_k127_965476_2 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 461.0
TLS3_k127_965476_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000001025 87.0
TLS3_k127_965476_4 - - - - 0.00000000000001733 78.0
TLS3_k127_967359_0 - - - - 1.123e-245 791.0
TLS3_k127_967359_1 acyl-CoA dehydrogenase activity K09456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005946 430.0
TLS3_k127_967359_2 acetylesterase activity - - - 0.0000000000000000000000000000000004083 147.0
TLS3_k127_967359_4 Vps9-ankyrin repeat-containing protein - - - 0.00000001322 67.0
TLS3_k127_970761_0 Belongs to the PEP-utilizing enzyme family K01006,K01007 - 2.7.9.1,2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 589.0
TLS3_k127_970761_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 400.0
TLS3_k127_970761_2 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.00000000000000000000000000000000000000000000000000001109 201.0
TLS3_k127_970761_3 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000001547 192.0
TLS3_k127_970761_4 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000002497 136.0
TLS3_k127_975213_0 Amidohydrolase family - - - 2.735e-216 678.0
TLS3_k127_975213_1 Bacterial regulatory protein, Fis family K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 559.0
TLS3_k127_975213_2 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 466.0
TLS3_k127_975213_3 PAS domain containing protein K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 340.0
TLS3_k127_975213_4 Dihydroorotate dehydrogenase K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000001497 163.0
TLS3_k127_975213_5 mannose-6-phosphate isomerase K01809,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000003737 155.0
TLS3_k127_975213_6 Protein of unknown function (DUF433) - - - 0.000000000000000000000000000000007265 130.0
TLS3_k127_975213_7 protein phosphatase 2C domain protein - - - 0.000000000000000000000000002958 129.0
TLS3_k127_975213_8 phosphorelay signal transduction system - - - 0.000000000000004228 81.0
TLS3_k127_975213_9 Polymer-forming cytoskeletal - - - 0.0000000000008787 74.0
TLS3_k127_979472_0 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 385.0
TLS3_k127_979472_1 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 291.0
TLS3_k127_979472_10 - - - - 0.000002423 54.0
TLS3_k127_979472_2 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000001015 224.0
TLS3_k127_979472_3 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000001147 200.0
TLS3_k127_979472_4 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000000002393 102.0
TLS3_k127_979472_7 OST-HTH/LOTUS domain - - - 0.0000000000000003426 87.0
TLS3_k127_979472_8 Putative addiction module component - - - 0.00000000000295 69.0
TLS3_k127_979472_9 Integrase core domain - - - 0.00000089 51.0
TLS3_k127_979553_0 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 424.0
TLS3_k127_979553_1 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 364.0
TLS3_k127_979553_2 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 333.0
TLS3_k127_979553_3 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 327.0
TLS3_k127_979553_4 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 316.0
TLS3_k127_979553_5 ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 302.0
TLS3_k127_979553_6 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000002754 170.0
TLS3_k127_990047_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.0 1065.0
TLS3_k127_990047_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 613.0
TLS3_k127_990047_10 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000003967 195.0
TLS3_k127_990047_11 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000000000000943 181.0
TLS3_k127_990047_12 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000000000000002763 166.0
TLS3_k127_990047_13 RibD C-terminal domain - - - 0.00000000000000000000000000000000000007259 142.0
TLS3_k127_990047_14 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000002416 135.0
TLS3_k127_990047_15 PHP domain protein - - - 0.000000000000000000000000002532 124.0
TLS3_k127_990047_16 enzyme binding K00567,K07443 - 2.1.1.63 0.000000000000000000001014 100.0
TLS3_k127_990047_17 Stress responsive A/B Barrel Domain - - - 0.000000000000159 74.0
TLS3_k127_990047_18 Thioesterase superfamily - - - 0.0000000000008271 77.0
TLS3_k127_990047_19 Protein of unknown function (DUF983) - - - 0.0000000004829 69.0
TLS3_k127_990047_2 ABC transporter, transmembrane K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 567.0
TLS3_k127_990047_20 lytic transglycosylase activity K03194 - - 0.0000000005618 71.0
TLS3_k127_990047_21 Encoded by - - - 0.0000000005682 70.0
TLS3_k127_990047_3 ABC transporter transmembrane region K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 551.0
TLS3_k127_990047_4 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 428.0
TLS3_k127_990047_5 PFAM Aldo keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 423.0
TLS3_k127_990047_6 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 413.0
TLS3_k127_990047_7 Uncharacterized conserved protein (COG2071) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001426 257.0
TLS3_k127_990047_8 Protein of unknown function (DUF541) K09797 - - 0.00000000000000000000000000000000000000000000000000000000000000004471 230.0
TLS3_k127_990047_9 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000002503 222.0