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Overview

ID MAG04058
Name TLS3_bin.44
Sample SMP0105
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class Nitrospiria
Order Nitrospirales
Family Nitrospiraceae
Genus Nitrospira_D
Species
Assembly information
Completeness (%) 95.26
Contamination (%) 0.37
GC content (%) 56.0
N50 (bp) 42,482
Genome size (bp) 3,840,146

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3248

Gene name Description KEGG GOs EC E-value Score Sequence
TLS3_k127_1018447_0 radical SAM domain protein - - - 0.0 1020.0
TLS3_k127_1018447_1 DNA methylase K07316 - 2.1.1.72 2.561e-290 911.0
TLS3_k127_1018447_10 Type I site-specific restriction-modification system, R (Restriction) subunit and related K01156 - 3.1.21.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 473.0
TLS3_k127_1018447_11 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 458.0
TLS3_k127_1018447_12 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008444 450.0
TLS3_k127_1018447_14 4 iron, 4 sulfur cluster binding K02573 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003349 265.0
TLS3_k127_1018447_16 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000005442 213.0
TLS3_k127_1018447_17 Domain of unknown function DUF1829 - - - 0.000000000000000000000000000009107 128.0
TLS3_k127_1018447_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000000000133 102.0
TLS3_k127_1018447_19 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000001531 102.0
TLS3_k127_1018447_2 NHL repeat - - - 3.22e-235 731.0
TLS3_k127_1018447_20 - - - - 0.0000000003881 66.0
TLS3_k127_1018447_3 - - - - 1.341e-206 644.0
TLS3_k127_1018447_4 denitrification pathway - - - 1.829e-203 641.0
TLS3_k127_1018447_5 denitrification pathway - - - 1.396e-198 627.0
TLS3_k127_1018447_6 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 4.784e-194 606.0
TLS3_k127_1018447_7 anaphase-promoting complex binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008185 606.0
TLS3_k127_1018447_8 Type I site-specific restriction-modification system, R (Restriction) subunit and related K01156 - 3.1.21.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 572.0
TLS3_k127_1018447_9 protein complex oligomerization - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 508.0
TLS3_k127_103672_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0 1200.0
TLS3_k127_103672_1 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 4.32e-287 888.0
TLS3_k127_103672_10 aldo-keto reductase (NADP) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 450.0
TLS3_k127_103672_11 RES - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 421.0
TLS3_k127_103672_12 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 419.0
TLS3_k127_103672_13 oxidoreductase activity K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 341.0
TLS3_k127_103672_14 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 329.0
TLS3_k127_103672_15 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000009277 263.0
TLS3_k127_103672_16 amine dehydrogenase activity K01406 - 3.4.24.40 0.0000000000000000000000000000000000000000000000000000000000000000000000003306 247.0
TLS3_k127_103672_17 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000001181 254.0
TLS3_k127_103672_18 response to oxidative stress K04063 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 - 0.00000000000000000000000000000000000000000000000000000000000001029 218.0
TLS3_k127_103672_19 lactoylglutathione lyase activity K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000001763 217.0
TLS3_k127_103672_2 serine-type endopeptidase activity K04771 - 3.4.21.107 2.65e-209 659.0
TLS3_k127_103672_20 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000002528 217.0
TLS3_k127_103672_22 NUDIX hydrolase - - - 0.000000000000000000000000000000000000000000000000000001198 196.0
TLS3_k127_103672_23 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000000000000000000000000003098 184.0
TLS3_k127_103672_24 chlorophyll binding K02051,K03286 - - 0.0000000000000000000000000000000000000000000002901 182.0
TLS3_k127_103672_25 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000000000000000001201 179.0
TLS3_k127_103672_26 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000001081 152.0
TLS3_k127_103672_27 domain protein K10716 - - 0.00000000000000000000000000000000000003867 151.0
TLS3_k127_103672_28 - - - - 0.00000000000000000000000000000000004043 136.0
TLS3_k127_103672_29 - - - - 0.0000000000000000000000000000000007439 137.0
TLS3_k127_103672_3 Elongation factor G, domain IV K02355 - - 1.128e-197 638.0
TLS3_k127_103672_30 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000001227 130.0
TLS3_k127_103672_31 - - - - 0.0000000000000000000000000007405 114.0
TLS3_k127_103672_32 Putative regulatory protein - - - 0.000000000000000000000000002949 114.0
TLS3_k127_103672_33 rRNA binding K00185,K02967 - - 0.0000000000000000001089 104.0
TLS3_k127_103672_35 rRNA binding K00185,K02967 - - 0.00000000000000003104 96.0
TLS3_k127_103672_36 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.0000000000000000721 82.0
TLS3_k127_103672_37 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000008905 76.0
TLS3_k127_103672_38 - - - - 0.00000000002792 73.0
TLS3_k127_103672_39 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.00000008984 57.0
TLS3_k127_103672_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 599.0
TLS3_k127_103672_40 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000008472 51.0
TLS3_k127_103672_41 - - - - 0.00008509 44.0
TLS3_k127_103672_5 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 597.0
TLS3_k127_103672_6 HI0933 family K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 533.0
TLS3_k127_103672_7 Animal haem peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009065 485.0
TLS3_k127_103672_8 PP-loop family K21947 - 2.8.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 465.0
TLS3_k127_103672_9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 450.0
TLS3_k127_1049833_0 peptidyl-tyrosine sulfation - - - 7.753e-197 662.0
TLS3_k127_1049833_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 467.0
TLS3_k127_1049833_2 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 399.0
TLS3_k127_1049833_3 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 305.0
TLS3_k127_1049833_4 protein transport across the cell outer membrane K02453,K03219 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009177 258.0
TLS3_k127_1049833_5 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000003657 147.0
TLS3_k127_1052172_0 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 525.0
TLS3_k127_1052172_1 Belongs to the glycosyl hydrolase 32 family K03332 GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575 3.2.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 462.0
TLS3_k127_1052172_2 Domain of unknown function (DUF4403) - - - 0.000016 57.0
TLS3_k127_1052172_3 Glycosyl transferase 4-like domain - - - 0.0001884 47.0
TLS3_k127_1131725_1 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000004934 239.0
TLS3_k127_1131725_2 Domain of unknown function (DUF4145) - - - 0.000000000000000000000000000000000000005596 153.0
TLS3_k127_1131725_3 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000005768 143.0
TLS3_k127_1131725_5 - - - - 0.00000000000000000003646 93.0
TLS3_k127_1131725_6 DNA integration K14059 - - 0.000003068 51.0
TLS3_k127_1131725_8 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0008077 46.0
TLS3_k127_1139681_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.26e-269 831.0
TLS3_k127_1139681_1 Circularly permuted ATP-grasp type 2 - - - 2.538e-219 689.0
TLS3_k127_1139681_2 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 409.0
TLS3_k127_1139681_3 PFAM 20S proteasome, A and B subunits K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 315.0
TLS3_k127_1139681_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000008957 221.0
TLS3_k127_1161536_0 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 2648.0
TLS3_k127_1161536_1 Type II/IV secretion system protein K02454,K02652 - - 0.0 1255.0
TLS3_k127_1161536_10 Trypsin K04771 - 3.4.21.107 8.155e-227 713.0
TLS3_k127_1161536_100 toxin-antitoxin pair type II binding - - - 0.000003517 51.0
TLS3_k127_1161536_101 Belongs to the peptidase S24 family K03503 - - 0.000006327 51.0
TLS3_k127_1161536_102 Cysteine rich repeat K06816 GO:0000137,GO:0000138,GO:0000139,GO:0001501,GO:0002376,GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005795,GO:0005797,GO:0005886,GO:0006810,GO:0006886,GO:0006928,GO:0007275,GO:0008104,GO:0008150,GO:0009653,GO:0009887,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0010955,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016477,GO:0017015,GO:0017134,GO:0019222,GO:0019838,GO:0023051,GO:0023057,GO:0030162,GO:0030512,GO:0031012,GO:0031090,GO:0031224,GO:0031323,GO:0031324,GO:0031984,GO:0031985,GO:0032268,GO:0032269,GO:0032330,GO:0032501,GO:0032502,GO:0033036,GO:0034613,GO:0040011,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045595,GO:0045861,GO:0046907,GO:0048513,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048705,GO:0048731,GO:0048856,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050900,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051239,GO:0051246,GO:0051248,GO:0051641,GO:0051649,GO:0051674,GO:0060255,GO:0060348,GO:0060349,GO:0061035,GO:0065007,GO:0070613,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0080090,GO:0090092,GO:0090101,GO:0090287,GO:0090288,GO:0098588,GO:0098791,GO:1903317,GO:1903318,GO:1903844,GO:1903845,GO:2000026 - 0.0001447 52.0
TLS3_k127_1161536_103 Integrase core domain K07497 - - 0.0004132 44.0
TLS3_k127_1161536_11 WD40-like Beta Propeller Repeat K03641 - - 1.694e-222 696.0
TLS3_k127_1161536_12 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 6.691e-211 671.0
TLS3_k127_1161536_13 phosphorelay signal transduction system - - - 1.726e-206 650.0
TLS3_k127_1161536_14 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.946e-199 638.0
TLS3_k127_1161536_15 Putative modulator of DNA gyrase K03592 - - 3.442e-196 621.0
TLS3_k127_1161536_16 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 603.0
TLS3_k127_1161536_17 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 598.0
TLS3_k127_1161536_18 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 610.0
TLS3_k127_1161536_2 Glycosyl hydrolase family 57 - - - 0.0 1028.0
TLS3_k127_1161536_20 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 580.0
TLS3_k127_1161536_21 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 572.0
TLS3_k127_1161536_22 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 571.0
TLS3_k127_1161536_23 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 555.0
TLS3_k127_1161536_24 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 554.0
TLS3_k127_1161536_25 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 545.0
TLS3_k127_1161536_26 Polyprenyl synthetase K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 529.0
TLS3_k127_1161536_28 actin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 487.0
TLS3_k127_1161536_29 Evidence 5 No homology to any previously reported sequences K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000087 492.0
TLS3_k127_1161536_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 2.167e-290 898.0
TLS3_k127_1161536_30 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 464.0
TLS3_k127_1161536_31 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 458.0
TLS3_k127_1161536_32 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 455.0
TLS3_k127_1161536_33 Polynucleotide adenylyltransferase K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009326 451.0
TLS3_k127_1161536_34 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 440.0
TLS3_k127_1161536_35 lytic transglycosylase activity K08306,K08308,K08309 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031225,GO:0031975,GO:0033554,GO:0034599,GO:0042221,GO:0042597,GO:0043170,GO:0044425,GO:0044462,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0061783,GO:0070887,GO:0071236,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 430.0
TLS3_k127_1161536_36 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 426.0
TLS3_k127_1161536_37 macromolecule localization K01421,K01992,K09690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 405.0
TLS3_k127_1161536_38 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 411.0
TLS3_k127_1161536_39 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 398.0
TLS3_k127_1161536_4 amino acid - - - 5.612e-265 827.0
TLS3_k127_1161536_40 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008865 388.0
TLS3_k127_1161536_41 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 376.0
TLS3_k127_1161536_42 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 376.0
TLS3_k127_1161536_43 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 370.0
TLS3_k127_1161536_44 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 370.0
TLS3_k127_1161536_45 PHP domain protein K01624,K07053 - 3.1.3.97,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008526 368.0
TLS3_k127_1161536_46 denitrification pathway K02569,K03532,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 355.0
TLS3_k127_1161536_47 tRNA (guanine(37)-N(1))-methyltransferase activity K01091,K01633,K15429 - 1.13.11.81,2.1.1.228,3.1.3.18,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 349.0
TLS3_k127_1161536_48 Mur ligase middle domain protein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 363.0
TLS3_k127_1161536_49 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006109 340.0
TLS3_k127_1161536_5 ATPase activity - - - 1.787e-261 812.0
TLS3_k127_1161536_50 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 332.0
TLS3_k127_1161536_51 2OG-Fe(II) oxygenase superfamily K07394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 322.0
TLS3_k127_1161536_52 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 310.0
TLS3_k127_1161536_53 Transposase K01991,K02557,K07161,K07484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005931 319.0
TLS3_k127_1161536_54 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 309.0
TLS3_k127_1161536_55 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 294.0
TLS3_k127_1161536_56 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003295 287.0
TLS3_k127_1161536_57 Outer membrane lipoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005144 278.0
TLS3_k127_1161536_58 Mo-molybdopterin cofactor metabolic process K03750,K03753,K13818 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.10.1.1,2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001431 272.0
TLS3_k127_1161536_59 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003702 263.0
TLS3_k127_1161536_6 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 8.427e-255 797.0
TLS3_k127_1161536_60 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000565 261.0
TLS3_k127_1161536_62 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000334 245.0
TLS3_k127_1161536_63 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001948 254.0
TLS3_k127_1161536_64 cysteine-type peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000002206 245.0
TLS3_k127_1161536_65 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.000000000000000000000000000000000000000000000000000000000000000000004908 252.0
TLS3_k127_1161536_66 Biopolymer transport protein ExbD/TolR K03560 - - 0.000000000000000000000000000000000000000000000000000000000000000001896 231.0
TLS3_k127_1161536_67 MotA/TolQ/ExbB proton channel family K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000004776 229.0
TLS3_k127_1161536_69 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000000000000000001872 220.0
TLS3_k127_1161536_7 Putative modulator of DNA gyrase K03568 - - 1.538e-250 779.0
TLS3_k127_1161536_70 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000009678 218.0
TLS3_k127_1161536_71 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000004873 204.0
TLS3_k127_1161536_72 PFAM Uncharacterised ACR, COG1259 K08999 - - 0.00000000000000000000000000000000000000000000000000000005092 200.0
TLS3_k127_1161536_73 energy transducer activity K03646,K03832 - - 0.0000000000000000000000000000000000000000000000000000006946 207.0
TLS3_k127_1161536_74 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000002203 196.0
TLS3_k127_1161536_75 - - - - 0.0000000000000000000000000000000000000000000000000000235 191.0
TLS3_k127_1161536_76 Integrase core domain - - - 0.000000000000000000000000000000000000000000000000004392 184.0
TLS3_k127_1161536_77 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000671 186.0
TLS3_k127_1161536_78 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000003899 190.0
TLS3_k127_1161536_79 COG3209 Rhs family protein - - - 0.00000000000000000000000000000000000000000000001719 192.0
TLS3_k127_1161536_8 Periplasmic binding protein - - - 4.394e-239 756.0
TLS3_k127_1161536_80 Domain of unknown function (DUF5069) - - - 0.00000000000000000000000000000000000000000000003612 172.0
TLS3_k127_1161536_82 RNA recognition motif - - - 0.0000000000000000000000000000000000000000001582 164.0
TLS3_k127_1161536_83 belongs to the thioredoxin family K00384,K03671 - 1.8.1.9 0.0000000000000000000000000000000001254 135.0
TLS3_k127_1161536_84 Response regulator, receiver - - - 0.000000000000000000000000000009237 124.0
TLS3_k127_1161536_85 - - - - 0.000000000000000000000000000773 119.0
TLS3_k127_1161536_86 lytic transglycosylase activity K08306,K08308,K08309 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031225,GO:0031975,GO:0033554,GO:0034599,GO:0042221,GO:0042597,GO:0043170,GO:0044425,GO:0044462,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0061783,GO:0070887,GO:0071236,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000004501 111.0
TLS3_k127_1161536_88 thiamine diphosphate biosynthetic process K03154 - - 0.00000000000000000000005791 99.0
TLS3_k127_1161536_89 Radical SAM superfamily K22226 - - 0.00000000000000000006274 96.0
TLS3_k127_1161536_9 Probable molybdopterin binding domain K03750 - 2.10.1.1 1.979e-234 730.0
TLS3_k127_1161536_90 Product type h extrachromosomal origin K07497 - - 0.0000000000000000004564 87.0
TLS3_k127_1161536_95 HNH endonuclease - - - 0.000000002461 68.0
TLS3_k127_1161536_98 Caspase domain - - - 0.0000001922 64.0
TLS3_k127_1161536_99 domain protein K20276 - - 0.0000002007 58.0
TLS3_k127_1189525_0 Alcohol dehydrogenase GroES-associated - - - 2.575e-209 656.0
TLS3_k127_1189525_1 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007679 584.0
TLS3_k127_1189525_10 Belongs to the Dps family - - - 0.0000000000000000000000000000000000000000000000000000000000006522 218.0
TLS3_k127_1189525_11 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000000000000000000000000003624 190.0
TLS3_k127_1189525_12 Glucose inhibited division protein A - - - 0.0000000000000000000000000000000000000000009041 169.0
TLS3_k127_1189525_13 Domain of unknown function (DUF4383) - - - 0.0000000000000000000000000000000000000001117 156.0
TLS3_k127_1189525_14 Transposase - - - 0.000000000000000000000000000000008683 128.0
TLS3_k127_1189525_15 Transposase - - - 0.0000000000000000000000000000008053 122.0
TLS3_k127_1189525_16 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000004081 113.0
TLS3_k127_1189525_17 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000128 111.0
TLS3_k127_1189525_18 - - - - 0.00000000000000000001557 97.0
TLS3_k127_1189525_19 Domain of unknown function (DUF4142) - - - 0.0000000000000002013 83.0
TLS3_k127_1189525_2 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 529.0
TLS3_k127_1189525_20 Transposase - - - 0.00000000000000533 76.0
TLS3_k127_1189525_21 Domain of unknown function (DUF4142) K08995 - - 0.0000000000002052 77.0
TLS3_k127_1189525_22 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000004638 62.0
TLS3_k127_1189525_23 Virulence factor BrkB K07058 - - 0.00000009817 57.0
TLS3_k127_1189525_24 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000288 49.0
TLS3_k127_1189525_3 RecQ zinc-binding K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 508.0
TLS3_k127_1189525_4 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 392.0
TLS3_k127_1189525_5 Domain of Unknown Function (DUF748) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 307.0
TLS3_k127_1189525_6 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009498 270.0
TLS3_k127_1189525_7 - K07275 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002355 255.0
TLS3_k127_1189525_8 belongs to the thioredoxin family K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000001311 224.0
TLS3_k127_1189525_9 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.0000000000000000000000000000000000000000000000000000000000000006013 230.0
TLS3_k127_120854_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1159.0
TLS3_k127_120854_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00003,K00982,K00990,K06950,K15371 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89 0.0 1083.0
TLS3_k127_120854_10 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 494.0
TLS3_k127_120854_11 (ABC) transporter K15738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 478.0
TLS3_k127_120854_12 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 432.0
TLS3_k127_120854_13 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 406.0
TLS3_k127_120854_14 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 408.0
TLS3_k127_120854_15 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 405.0
TLS3_k127_120854_16 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007977 396.0
TLS3_k127_120854_17 Major Facilitator Superfamily K02575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 375.0
TLS3_k127_120854_18 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007233 340.0
TLS3_k127_120854_19 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 309.0
TLS3_k127_120854_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 8.615e-318 977.0
TLS3_k127_120854_20 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 310.0
TLS3_k127_120854_21 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003449 274.0
TLS3_k127_120854_22 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001667 251.0
TLS3_k127_120854_23 peroxiredoxin activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002835 244.0
TLS3_k127_120854_24 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000001276 207.0
TLS3_k127_120854_25 protein homooligomerization - - - 0.0000000000000000000000000000000000000000000000000000000166 213.0
TLS3_k127_120854_26 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000000000001964 192.0
TLS3_k127_120854_27 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000000000000000001393 175.0
TLS3_k127_120854_28 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000001654 182.0
TLS3_k127_120854_3 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.186e-316 991.0
TLS3_k127_120854_30 Kelch motif - - - 0.00000000000000000000000000000000000002949 165.0
TLS3_k127_120854_31 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.000000000000000000000000000000000006099 139.0
TLS3_k127_120854_32 Galactose oxidase, central domain - - - 0.0000000000000000000000000000000131 147.0
TLS3_k127_120854_33 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01923,K01952 - 6.3.2.6,6.3.5.3 0.0000000000000000000000000000001682 125.0
TLS3_k127_120854_39 HDOD domain - - - 0.000000000000000003933 98.0
TLS3_k127_120854_4 methyltransferase - - - 1.284e-264 822.0
TLS3_k127_120854_40 Sugar-transfer associated ATP-grasp - - - 0.0000000000000006704 83.0
TLS3_k127_120854_43 Sugar-transfer associated ATP-grasp - - - 0.000000001158 59.0
TLS3_k127_120854_44 Protein of unknown function, DUF393 - - - 0.000002425 55.0
TLS3_k127_120854_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 8.259e-262 811.0
TLS3_k127_120854_6 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 4.364e-232 725.0
TLS3_k127_120854_7 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 3.621e-223 695.0
TLS3_k127_120854_8 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 4.053e-215 681.0
TLS3_k127_120854_9 photosynthesis K02453,K02660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 513.0
TLS3_k127_1229926_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 589.0
TLS3_k127_1229926_1 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 381.0
TLS3_k127_1229926_10 protein conserved in bacteria - - - 0.000000005965 65.0
TLS3_k127_1229926_11 RNA-DNA hybrid ribonuclease activity K03471 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000007852 57.0
TLS3_k127_1229926_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 370.0
TLS3_k127_1229926_3 zinc finger K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 352.0
TLS3_k127_1229926_4 Phosphoribosyl-AMP cyclohydrolase K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 311.0
TLS3_k127_1229926_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 304.0
TLS3_k127_1229926_6 C4-type zinc ribbon domain K07164 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001541 277.0
TLS3_k127_1229926_8 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.00000000000000000000000000000000000000000000008899 171.0
TLS3_k127_1229926_9 Transposase - - - 0.00000000000000000000000000001088 118.0
TLS3_k127_1243154_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1332.0
TLS3_k127_1243154_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0 1110.0
TLS3_k127_1243154_10 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 555.0
TLS3_k127_1243154_11 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 545.0
TLS3_k127_1243154_12 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 462.0
TLS3_k127_1243154_13 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 459.0
TLS3_k127_1243154_14 Animal haem peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008195 463.0
TLS3_k127_1243154_15 DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 433.0
TLS3_k127_1243154_16 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 422.0
TLS3_k127_1243154_17 metalloendopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007248 397.0
TLS3_k127_1243154_18 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 387.0
TLS3_k127_1243154_19 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 358.0
TLS3_k127_1243154_2 Cytochrome c-type biogenesis protein CcmF K02198 - - 2.068e-308 957.0
TLS3_k127_1243154_20 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 346.0
TLS3_k127_1243154_21 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 331.0
TLS3_k127_1243154_22 RNA-DNA hybrid ribonuclease activity K03471 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 319.0
TLS3_k127_1243154_23 ACT domain K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004981 301.0
TLS3_k127_1243154_24 shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 308.0
TLS3_k127_1243154_25 Cytochrome c-type biogenesis protein K02200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007068 299.0
TLS3_k127_1243154_26 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002809 282.0
TLS3_k127_1243154_27 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003684 282.0
TLS3_k127_1243154_28 oxidoreductase DsbE K02199 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003692 251.0
TLS3_k127_1243154_29 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000001724 209.0
TLS3_k127_1243154_3 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 1.225e-306 949.0
TLS3_k127_1243154_30 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000000000000000009703 204.0
TLS3_k127_1243154_31 RDD family - - - 0.0000000000000000000000000000000000000000000000000000002166 197.0
TLS3_k127_1243154_32 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000000000000000000005692 171.0
TLS3_k127_1243154_33 membrane - - - 0.0000000000000000000000000000000000000000001683 164.0
TLS3_k127_1243154_34 PFAM Cupin - - - 0.00000000000000000000000000000000000003245 146.0
TLS3_k127_1243154_36 - - - - 0.0000000000000000000000000000002482 128.0
TLS3_k127_1243154_37 Protein of unknown function (DUF2905) - - - 0.000000000000000000001587 96.0
TLS3_k127_1243154_38 Region found in RelA / SpoT proteins - - - 0.0000000000106 68.0
TLS3_k127_1243154_39 Lipid A 3-O-deacylase (PagL) - - - 0.000000000428 68.0
TLS3_k127_1243154_4 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 7.854e-275 853.0
TLS3_k127_1243154_40 anaerobic respiration K10535 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114 1.7.2.6 0.000000002439 60.0
TLS3_k127_1243154_41 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.00000001864 59.0
TLS3_k127_1243154_42 PIN domain K07064 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944 - 0.0000001172 59.0
TLS3_k127_1243154_45 - - - - 0.00004407 50.0
TLS3_k127_1243154_46 positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0001727 48.0
TLS3_k127_1243154_5 Actin K03569 - - 3.308e-204 638.0
TLS3_k127_1243154_6 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 2.313e-200 627.0
TLS3_k127_1243154_7 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 601.0
TLS3_k127_1243154_8 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007084 590.0
TLS3_k127_1243154_9 Sugar (and other) transporter K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 582.0
TLS3_k127_1286769_0 belongs to the thioredoxin family K02453,K07280,K20444,K20543 - - 0.0 1325.0
TLS3_k127_1286769_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 4.881e-307 969.0
TLS3_k127_1286769_10 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 572.0
TLS3_k127_1286769_11 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 546.0
TLS3_k127_1286769_12 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 539.0
TLS3_k127_1286769_13 Flagellar basal body rod FlgEFG protein C-terminal K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 486.0
TLS3_k127_1286769_14 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 473.0
TLS3_k127_1286769_15 Chemotaxis protein methyltransferase K00575 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 427.0
TLS3_k127_1286769_16 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 430.0
TLS3_k127_1286769_17 MotA/TolQ/ExbB proton channel family K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 405.0
TLS3_k127_1286769_18 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 402.0
TLS3_k127_1286769_19 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 369.0
TLS3_k127_1286769_2 DUF based on E. rectale Gene description (DUF3880) K06320 - - 2.999e-213 679.0
TLS3_k127_1286769_20 bacterial-type flagellum organization K04562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 364.0
TLS3_k127_1286769_21 Sigma-70, region 4 K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 353.0
TLS3_k127_1286769_22 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 390.0
TLS3_k127_1286769_23 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 351.0
TLS3_k127_1286769_24 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 341.0
TLS3_k127_1286769_25 General secretion pathway protein F K02455,K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 347.0
TLS3_k127_1286769_26 Flagellar basal body rod FlgEFG protein C-terminal K02392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 329.0
TLS3_k127_1286769_27 Cellulose biosynthesis protein BcsQ K04562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 325.0
TLS3_k127_1286769_28 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 331.0
TLS3_k127_1286769_29 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411,K03412 GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 304.0
TLS3_k127_1286769_3 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 5.351e-209 652.0
TLS3_k127_1286769_30 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843,K02849 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006853 288.0
TLS3_k127_1286769_31 phosphorelay signal transduction system K02282,K02482,K04757,K20977 - 2.7.11.1,2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003149 284.0
TLS3_k127_1286769_32 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001162 274.0
TLS3_k127_1286769_33 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K03408 - - 0.000000000000000000000000000000000000000000000000000000000000000001228 233.0
TLS3_k127_1286769_34 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001747 261.0
TLS3_k127_1286769_35 SRP54-type protein, GTPase domain K02404 - - 0.0000000000000000000000000000000000000000000000000000000000001536 229.0
TLS3_k127_1286769_36 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000000000001486 211.0
TLS3_k127_1286769_37 regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed - - - 0.000000000000000000000000000000000000000000000000000000000004505 216.0
TLS3_k127_1286769_38 phosphorelay signal transduction system K07714 - - 0.0000000000000000000000000000000000000000000000000000001483 208.0
TLS3_k127_1286769_39 Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum K13626 - - 0.000000000000000000000000000000000000000000000000000002936 195.0
TLS3_k127_1286769_4 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 4.271e-198 633.0
TLS3_k127_1286769_40 bacterial-type flagellum organization K02279,K02386 - - 0.0000000000000000000000000000000000000000000000000001521 195.0
TLS3_k127_1286769_41 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000000000003362 188.0
TLS3_k127_1286769_43 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000000000000000009869 180.0
TLS3_k127_1286769_44 Flagellar protein FliS K02422 - - 0.00000000000000000000000000000000000000000002091 164.0
TLS3_k127_1286769_45 Chemotaxis phosphatase, CheZ K03414 - - 0.000000000000000000000000000000000000001015 154.0
TLS3_k127_1286769_46 PFAM General secretion pathway protein K K02460 - - 0.0000000000000000000000000000000000003085 153.0
TLS3_k127_1286769_48 antisigma factor binding - - - 0.00000000000000000000000000000000005569 136.0
TLS3_k127_1286769_49 Bacterial flagellin N-terminal helical region K02397 - - 0.000000000000000000000000009381 126.0
TLS3_k127_1286769_5 Pas domain K03406 - - 1.746e-195 637.0
TLS3_k127_1286769_50 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563,K13626 - - 0.0000000000000000000000006699 106.0
TLS3_k127_1286769_51 DNA excision K02806 - - 0.000000000000000000000002592 110.0
TLS3_k127_1286769_52 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.00000000000000000000007282 113.0
TLS3_k127_1286769_53 bacterial-type flagellum organization K02398 GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009892,GO:0010556,GO:0010605,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031324,GO:0031326,GO:0032268,GO:0032269,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.0000000000000000000175 94.0
TLS3_k127_1286769_54 General secretion pathway protein C K02452 - - 0.000000000000000003843 95.0
TLS3_k127_1286769_55 Flagellar rod assembly protein muramidase FlgJ K02395,K08309 - - 0.000000000000007811 79.0
TLS3_k127_1286769_56 Type II secretion system (T2SS), protein M K02462 - - 0.0000000000001222 79.0
TLS3_k127_1286769_57 PAS fold - - - 0.0000000000001878 80.0
TLS3_k127_1286769_58 Histidine kinase K20976 - - 0.000000000003966 71.0
TLS3_k127_1286769_59 flagellar protein FlaG K06603 - - 0.00000000549 62.0
TLS3_k127_1286769_6 mechanosensitive ion channel activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 604.0
TLS3_k127_1286769_60 transmembrane signaling receptor activity K03406 - - 0.0000009393 58.0
TLS3_k127_1286769_61 General secretion pathway protein J K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.00001414 56.0
TLS3_k127_1286769_62 transporter antisigma-factor antagonist STAS - - - 0.00001663 51.0
TLS3_k127_1286769_63 overlaps another CDS with the same product name K02458 - - 0.0000186 52.0
TLS3_k127_1286769_64 STAS domain K20978 - - 0.00002259 49.0
TLS3_k127_1286769_66 General secretion pathway protein H K02457 - - 0.0002094 51.0
TLS3_k127_1286769_7 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 587.0
TLS3_k127_1286769_8 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 569.0
TLS3_k127_1286769_9 Chemotaxis protein histidine kinase K03407 GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003395 588.0
TLS3_k127_1319716_0 AcrB/AcrD/AcrF family - - - 0.0 1685.0
TLS3_k127_1319716_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1536.0
TLS3_k127_1319716_10 DNA methylase K03427 - 2.1.1.72 2.137e-284 880.0
TLS3_k127_1319716_100 Protein of unknown function (DUF2877) - - - 0.000000000000000003089 96.0
TLS3_k127_1319716_102 recombinase activity - - - 0.0000000000000001889 81.0
TLS3_k127_1319716_103 - - - - 0.0000000000000003546 79.0
TLS3_k127_1319716_104 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.0000000000000007035 78.0
TLS3_k127_1319716_106 PFAM membrane protein of K08972 - - 0.0000000000002423 76.0
TLS3_k127_1319716_107 - - - - 0.0000000000002498 76.0
TLS3_k127_1319716_108 PFAM DNA polymerase beta domain protein region K07076 - - 0.0000000000004363 73.0
TLS3_k127_1319716_11 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 4.852e-254 787.0
TLS3_k127_1319716_110 Nucleotidyltransferase domain - - - 0.000000000173 66.0
TLS3_k127_1319716_111 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01154 - 3.1.21.3 0.00000000471 64.0
TLS3_k127_1319716_112 mercury ion transmembrane transporter activity K08364 - - 0.00000002506 61.0
TLS3_k127_1319716_113 DDE domain - - - 0.0000001917 56.0
TLS3_k127_1319716_114 Nucleotidyltransferase domain - - - 0.000000313 56.0
TLS3_k127_1319716_117 conserved protein, contains double-stranded beta-helix domain - - - 0.000001828 51.0
TLS3_k127_1319716_118 Evidence 5 No homology to any previously reported sequences - - - 0.000008844 51.0
TLS3_k127_1319716_119 Protein of unknown function (DUF2283) - - - 0.0004035 45.0
TLS3_k127_1319716_12 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 4.641e-251 789.0
TLS3_k127_1319716_13 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342 - 1.6.5.3 2.522e-236 741.0
TLS3_k127_1319716_14 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 1.551e-216 684.0
TLS3_k127_1319716_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 9.793e-212 669.0
TLS3_k127_1319716_16 Protein of unknown function (DUF1116) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 612.0
TLS3_k127_1319716_17 TIGRFAM phosphoenolpyruvate phosphomutase K01841 - 5.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 610.0
TLS3_k127_1319716_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 593.0
TLS3_k127_1319716_19 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 588.0
TLS3_k127_1319716_2 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.0 1302.0
TLS3_k127_1319716_20 Evidence 2b Function of strongly homologous gene K01740,K03430,K05306,K09469 GO:0003674,GO:0003824 2.5.1.49,2.6.1.37,3.11.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 572.0
TLS3_k127_1319716_21 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 564.0
TLS3_k127_1319716_22 NmrA-like family K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 553.0
TLS3_k127_1319716_23 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 535.0
TLS3_k127_1319716_24 Multicopper oxidase type 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 537.0
TLS3_k127_1319716_25 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00992 - 2.7.7.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 534.0
TLS3_k127_1319716_26 ABC transporter substrate-binding protein PnrA-like K02058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 522.0
TLS3_k127_1319716_28 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 511.0
TLS3_k127_1319716_29 CoA-ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 507.0
TLS3_k127_1319716_3 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1269.0
TLS3_k127_1319716_30 Protein of unknown function (DUF2914) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007952 497.0
TLS3_k127_1319716_31 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005958 496.0
TLS3_k127_1319716_32 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007018 481.0
TLS3_k127_1319716_33 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 477.0
TLS3_k127_1319716_34 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 447.0
TLS3_k127_1319716_35 PFAM Branched-chain amino acid transport system permease component K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 439.0
TLS3_k127_1319716_36 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 411.0
TLS3_k127_1319716_37 lysyltransferase activity K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007108 408.0
TLS3_k127_1319716_38 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 388.0
TLS3_k127_1319716_39 Nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 381.0
TLS3_k127_1319716_4 helicase activity - - - 0.0 1195.0
TLS3_k127_1319716_40 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 378.0
TLS3_k127_1319716_41 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 376.0
TLS3_k127_1319716_42 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009949 359.0
TLS3_k127_1319716_43 Belongs to the TPP enzyme family K09459 - 4.1.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 349.0
TLS3_k127_1319716_44 transmembrane transport K02532,K05820,K08167,K08218,K08369 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 346.0
TLS3_k127_1319716_45 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 321.0
TLS3_k127_1319716_46 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006415 306.0
TLS3_k127_1319716_47 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 305.0
TLS3_k127_1319716_48 PFAM isochorismatase hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 309.0
TLS3_k127_1319716_49 Protein of unknown function (DUF3800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 304.0
TLS3_k127_1319716_5 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1103.0
TLS3_k127_1319716_50 STAS-like domain of unknown function (DUF4325) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009592 313.0
TLS3_k127_1319716_51 Copper resistance protein B precursor (CopB) K07233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 302.0
TLS3_k127_1319716_52 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 294.0
TLS3_k127_1319716_53 2 iron, 2 sulfur cluster binding K00334,K03943 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 293.0
TLS3_k127_1319716_54 Uncharacterized protein family, UPF0114 K03535 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 285.0
TLS3_k127_1319716_55 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 296.0
TLS3_k127_1319716_56 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008326 275.0
TLS3_k127_1319716_57 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K09459 - 4.1.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000142 273.0
TLS3_k127_1319716_58 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03673 GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000104 272.0
TLS3_k127_1319716_59 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003575 263.0
TLS3_k127_1319716_6 TonB-dependent receptor - - - 0.0 1060.0
TLS3_k127_1319716_60 Multicopper oxidase type 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004948 252.0
TLS3_k127_1319716_61 cell redox homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005104 246.0
TLS3_k127_1319716_62 Restriction modification system DNA specificity domain K01154 - 3.1.21.3 0.00000000000000000000000000000000000000000000000000000000000000000000009071 252.0
TLS3_k127_1319716_63 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001259 239.0
TLS3_k127_1319716_64 peptide-methionine (R)-S-oxide reductase K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000001603 236.0
TLS3_k127_1319716_66 response to nickel cation K07722 GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000001066 230.0
TLS3_k127_1319716_67 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000002605 213.0
TLS3_k127_1319716_68 hmm pf01609 - - - 0.0000000000000000000000000000000000000000000000000000000000007288 228.0
TLS3_k127_1319716_69 acetyltransferase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000000001171 210.0
TLS3_k127_1319716_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.0 1014.0
TLS3_k127_1319716_70 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K00797,K01611 - 2.5.1.16,4.1.1.50 0.0000000000000000000000000000000000000000000000000000000002181 205.0
TLS3_k127_1319716_71 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000001987 203.0
TLS3_k127_1319716_72 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000007372 201.0
TLS3_k127_1319716_73 Protein conserved in bacteria K01153 - 3.1.21.3 0.00000000000000000000000000000000000000000000000000000002725 200.0
TLS3_k127_1319716_75 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000009719 194.0
TLS3_k127_1319716_76 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000001449 193.0
TLS3_k127_1319716_78 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.000000000000000000000000000000000000000000000000004778 187.0
TLS3_k127_1319716_79 - - - - 0.00000000000000000000000000000000000000000000000003254 186.0
TLS3_k127_1319716_8 NADH-quinone oxidoreductase K00341 - 1.6.5.3 5.225e-316 976.0
TLS3_k127_1319716_80 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000468 177.0
TLS3_k127_1319716_82 - - - - 0.00000000000000000000000000000000000000000000004643 174.0
TLS3_k127_1319716_84 Acyl-homoserine-lactone synthase K13060,K13061,K18096,K20248,K20249,K20250 - 2.3.1.184,2.3.1.228,2.3.1.229 0.000000000000000000000000000000000000000000168 168.0
TLS3_k127_1319716_85 PFAM Bacterial regulatory proteins, gntR family - - - 0.00000000000000000000000000000000000000005569 162.0
TLS3_k127_1319716_86 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000000000003008 145.0
TLS3_k127_1319716_88 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000167 147.0
TLS3_k127_1319716_89 Sterol carrier protein - - - 0.0000000000000000000000000000000000001884 143.0
TLS3_k127_1319716_9 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.119e-301 933.0
TLS3_k127_1319716_90 response regulator - - - 0.0000000000000000000000000000000000004484 150.0
TLS3_k127_1319716_91 Domain of unknown function (DUF3842) - - - 0.00000000000000000000000000000000002921 138.0
TLS3_k127_1319716_92 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.00000000000000000000000000000000008049 141.0
TLS3_k127_1319716_93 PFAM IS1 transposase - - - 0.000000000000000000000000000000006293 138.0
TLS3_k127_1319716_94 Autoinducer binding domain - - - 0.00000000000000000000000000000002998 137.0
TLS3_k127_1319716_95 - - - - 0.0000000000000000000000000000027 126.0
TLS3_k127_1319716_96 Histidine kinase K07682 GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.0000000000000000000000000003498 124.0
TLS3_k127_1319716_97 Protein of unknown function (DUF3175) - - - 0.000000000000000000000000003218 114.0
TLS3_k127_1319716_99 Protein conserved in bacteria K09922 - - 0.0000000000000000000000533 98.0
TLS3_k127_1354823_0 Aconitase C-terminal domain K01681 - 4.2.1.3 0.0 1373.0
TLS3_k127_1354823_1 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.0 1292.0
TLS3_k127_1354823_10 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 1.269e-231 721.0
TLS3_k127_1354823_11 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 2.006e-216 677.0
TLS3_k127_1354823_12 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 1.059e-204 647.0
TLS3_k127_1354823_13 Type II secretion system (T2SS), protein F K02455,K02653 - - 8.96e-198 623.0
TLS3_k127_1354823_14 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 1.575e-196 616.0
TLS3_k127_1354823_15 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 2.148e-194 612.0
TLS3_k127_1354823_16 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 587.0
TLS3_k127_1354823_17 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 591.0
TLS3_k127_1354823_18 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 586.0
TLS3_k127_1354823_19 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 534.0
TLS3_k127_1354823_2 DNA-directed DNA polymerase K02337,K14162 - 2.7.7.7 0.0 1273.0
TLS3_k127_1354823_20 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004509 527.0
TLS3_k127_1354823_21 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 523.0
TLS3_k127_1354823_22 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 515.0
TLS3_k127_1354823_23 Methylenetetrahydrofolate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 508.0
TLS3_k127_1354823_24 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 489.0
TLS3_k127_1354823_25 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 490.0
TLS3_k127_1354823_26 response regulator K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 497.0
TLS3_k127_1354823_27 Cell cycle protein K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007385 492.0
TLS3_k127_1354823_28 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 458.0
TLS3_k127_1354823_29 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 459.0
TLS3_k127_1354823_3 Belongs to the citrate synthase family K01902,K15230,K15233 - 2.3.3.8,6.2.1.5 0.0 1167.0
TLS3_k127_1354823_30 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 436.0
TLS3_k127_1354823_31 Cell wall formation K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 433.0
TLS3_k127_1354823_32 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 411.0
TLS3_k127_1354823_33 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 398.0
TLS3_k127_1354823_34 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 395.0
TLS3_k127_1354823_35 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 397.0
TLS3_k127_1354823_36 PFAM Integrase catalytic region K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009262 388.0
TLS3_k127_1354823_37 6-phosphogluconolactonase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 372.0
TLS3_k127_1354823_38 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 364.0
TLS3_k127_1354823_39 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 351.0
TLS3_k127_1354823_4 5TM C-terminal transporter carbon starvation CstA K06200 - - 0.0 1145.0
TLS3_k127_1354823_40 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 355.0
TLS3_k127_1354823_41 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 342.0
TLS3_k127_1354823_42 Mitochondrial small ribosomal subunit Rsm22 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 345.0
TLS3_k127_1354823_44 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 327.0
TLS3_k127_1354823_45 phosphoprotein phosphatase activity K01525 GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 325.0
TLS3_k127_1354823_46 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 310.0
TLS3_k127_1354823_47 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 313.0
TLS3_k127_1354823_48 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 283.0
TLS3_k127_1354823_49 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003712 276.0
TLS3_k127_1354823_5 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 5.978e-264 823.0
TLS3_k127_1354823_50 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000914 275.0
TLS3_k127_1354823_51 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009582 273.0
TLS3_k127_1354823_52 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001008 259.0
TLS3_k127_1354823_53 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000001985 261.0
TLS3_k127_1354823_54 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001277 255.0
TLS3_k127_1354823_55 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007986 248.0
TLS3_k127_1354823_56 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000001012 231.0
TLS3_k127_1354823_57 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000001938 235.0
TLS3_k127_1354823_58 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000000000000000000002008 220.0
TLS3_k127_1354823_59 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000001034 216.0
TLS3_k127_1354823_6 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 2.311e-262 811.0
TLS3_k127_1354823_60 DivIVA protein K04074 - - 0.0000000000000000000000000000000000000000000000000000000000007115 214.0
TLS3_k127_1354823_61 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000002559 212.0
TLS3_k127_1354823_62 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.0000000000000000000000000000000000000000000000000000000473 201.0
TLS3_k127_1354823_63 MFS_1 like family - - - 0.0000000000000000000000000000000000000000000000000006826 200.0
TLS3_k127_1354823_64 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K01921,K03589,K06438 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 0.00000000000000000000000000000000000000000000000003654 189.0
TLS3_k127_1354823_67 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000000000000000000006648 171.0
TLS3_k127_1354823_69 phosphatase - - - 0.000000000000000000000000000000000005464 141.0
TLS3_k127_1354823_7 phosphorelay sensor kinase activity K02668 - 2.7.13.3 5.436e-249 780.0
TLS3_k127_1354823_70 YGGT family K02221 - - 0.000000000000000000000000000000000009483 138.0
TLS3_k127_1354823_71 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000002448 131.0
TLS3_k127_1354823_72 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000001149 112.0
TLS3_k127_1354823_74 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000006665 100.0
TLS3_k127_1354823_75 iron ion binding - - - 0.000000000000000000001045 99.0
TLS3_k127_1354823_76 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.000000000000001089 78.0
TLS3_k127_1354823_77 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000001168 76.0
TLS3_k127_1354823_79 - - - - 0.00000003111 63.0
TLS3_k127_1354823_8 Belongs to the MurCDEF family K01924 - 6.3.2.8 4.205e-247 769.0
TLS3_k127_1354823_80 Fatty acid hydroxylase superfamily - - - 0.00005419 51.0
TLS3_k127_1354823_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 4.968e-242 752.0
TLS3_k127_1381067_0 Nitrite and sulphite reductase 4Fe-4S domain K00362,K00392 - 1.7.1.15,1.8.7.1 0.0 1296.0
TLS3_k127_1381067_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1013.0
TLS3_k127_1381067_10 Glycosyl transferase family, a/b domain K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 447.0
TLS3_k127_1381067_11 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 427.0
TLS3_k127_1381067_12 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 424.0
TLS3_k127_1381067_13 sulfate reduction K00390,K00860 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8,2.7.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 365.0
TLS3_k127_1381067_14 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 331.0
TLS3_k127_1381067_15 Proto-chlorophyllide reductase 57 kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006082 319.0
TLS3_k127_1381067_16 Translation initiation factor IF-3, C-terminal domain K02520 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 289.0
TLS3_k127_1381067_17 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000265 246.0
TLS3_k127_1381067_18 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000000000000001208 187.0
TLS3_k127_1381067_2 sulfate adenylyltransferase (ATP) activity K00860,K00955,K00956 - 2.7.1.25,2.7.7.4 5.1e-309 955.0
TLS3_k127_1381067_20 sequence-specific DNA binding K03557,K07712 GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000004773 168.0
TLS3_k127_1381067_21 2 iron, 2 sulfur cluster binding K04487,K13643 - 2.8.1.7 0.00000000000000000000000000000000000000000009652 163.0
TLS3_k127_1381067_22 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000000000007935 146.0
TLS3_k127_1381067_23 - - - - 0.000000000000000000000002122 102.0
TLS3_k127_1381067_24 - - - - 0.000000000000000000001663 96.0
TLS3_k127_1381067_25 Transcriptional regulatory protein, C terminal - - - 0.000000000000002267 82.0
TLS3_k127_1381067_26 Ribosomal protein L35 K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000006769 73.0
TLS3_k127_1381067_27 COG0732 Restriction endonuclease S subunits K01154 - 3.1.21.3 0.0000000000001163 77.0
TLS3_k127_1381067_28 - - - - 0.00000002273 56.0
TLS3_k127_1381067_3 B3/4 domain K01890 - 6.1.1.20 2.142e-247 776.0
TLS3_k127_1381067_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type K01889 - 6.1.1.20 2.033e-243 760.0
TLS3_k127_1381067_5 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 600.0
TLS3_k127_1381067_6 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 533.0
TLS3_k127_1381067_7 sulfate reduction K00390,K00957 - 1.8.4.10,1.8.4.8,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008062 508.0
TLS3_k127_1381067_8 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 457.0
TLS3_k127_1381067_9 16S rRNA methyltransferase RsmB/F K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 459.0
TLS3_k127_1395764_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 2048.0
TLS3_k127_1395764_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1183.0
TLS3_k127_1395764_10 Evidence 4 Homologs of previously reported genes of - - - 2.706e-226 709.0
TLS3_k127_1395764_11 DNA topoisomerase VI subunit A K03166 - 5.99.1.3 6.747e-221 687.0
TLS3_k127_1395764_12 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 5.352e-220 688.0
TLS3_k127_1395764_13 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 7.324e-216 674.0
TLS3_k127_1395764_14 spermidine synthase activity K00797 - 2.5.1.16 7.108e-214 676.0
TLS3_k127_1395764_15 Carbon-nitrogen hydrolase K03820 - - 3.715e-205 651.0
TLS3_k127_1395764_16 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 622.0
TLS3_k127_1395764_17 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 607.0
TLS3_k127_1395764_18 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 601.0
TLS3_k127_1395764_19 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 615.0
TLS3_k127_1395764_2 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.0 1103.0
TLS3_k127_1395764_20 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 576.0
TLS3_k127_1395764_21 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003831 575.0
TLS3_k127_1395764_22 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 570.0
TLS3_k127_1395764_23 methyltransferase K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 565.0
TLS3_k127_1395764_24 stress-induced mitochondrial fusion K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 539.0
TLS3_k127_1395764_25 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 519.0
TLS3_k127_1395764_26 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003913 496.0
TLS3_k127_1395764_27 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 483.0
TLS3_k127_1395764_28 Acetyl-coenzyme A transporter 1 K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 468.0
TLS3_k127_1395764_29 PFAM Binding-protein-dependent transport system inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 433.0
TLS3_k127_1395764_3 PD-(D/E)XK nuclease superfamily - - - 0.0 1055.0
TLS3_k127_1395764_30 mannose-ethanolamine phosphotransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 420.0
TLS3_k127_1395764_31 Protein involved in response to NO K07234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005794 424.0
TLS3_k127_1395764_32 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005357 418.0
TLS3_k127_1395764_33 FES K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 411.0
TLS3_k127_1395764_34 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 416.0
TLS3_k127_1395764_35 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 392.0
TLS3_k127_1395764_36 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 386.0
TLS3_k127_1395764_37 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 383.0
TLS3_k127_1395764_38 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009078 381.0
TLS3_k127_1395764_39 Galactose oxidase, central domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 378.0
TLS3_k127_1395764_4 DNA topoisomerase II activity K03167 - 5.99.1.3 0.0 1022.0
TLS3_k127_1395764_40 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 378.0
TLS3_k127_1395764_41 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 370.0
TLS3_k127_1395764_42 DNA replication proofreading K02336,K06877,K07501 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 368.0
TLS3_k127_1395764_43 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005669 367.0
TLS3_k127_1395764_44 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009563 367.0
TLS3_k127_1395764_45 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 340.0
TLS3_k127_1395764_46 Peptidase C26 K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 322.0
TLS3_k127_1395764_47 stress-induced mitochondrial fusion K04087 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 316.0
TLS3_k127_1395764_48 amino acid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 304.0
TLS3_k127_1395764_49 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001782 283.0
TLS3_k127_1395764_5 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 2.617e-273 846.0
TLS3_k127_1395764_50 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007172 260.0
TLS3_k127_1395764_51 GDP-mannose mannosyl hydrolase activity K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000002388 250.0
TLS3_k127_1395764_52 - K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000005567 251.0
TLS3_k127_1395764_53 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005434 245.0
TLS3_k127_1395764_56 AhpC/TSA family K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000001162 234.0
TLS3_k127_1395764_57 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000000002431 239.0
TLS3_k127_1395764_58 ACT domain - - - 0.00000000000000000000000000000000000000000000000000000000000008472 215.0
TLS3_k127_1395764_59 coenzyme F420 binding K07226 - - 0.0000000000000000000000000000000000000000000000000000000000002994 216.0
TLS3_k127_1395764_6 ATP-dependent DNA helicase (RecQ) K03654 - 3.6.4.12 6.625e-268 836.0
TLS3_k127_1395764_60 Phosphate ABC transporter substrate-binding protein, PhoT family K02040 - - 0.000000000000000000000000000000000000000000000000000000000002259 220.0
TLS3_k127_1395764_62 - - - - 0.0000000000000000000000000000000000000000000000000000001959 196.0
TLS3_k127_1395764_63 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000000000000000000000000000003719 196.0
TLS3_k127_1395764_65 nUDIX hydrolase K03574,K03575 - 3.6.1.55 0.000000000000000000000000000000000000000000000000522 179.0
TLS3_k127_1395764_67 Thioredoxin domain - - - 0.000000000000000000000000000000000000000006501 154.0
TLS3_k127_1395764_68 LysM domain - - - 0.00000000000000000000000000000000000000003105 161.0
TLS3_k127_1395764_69 Zincin-like metallopeptidase - - - 0.00000000000000000000000000000000000000003905 154.0
TLS3_k127_1395764_7 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 1.824e-249 777.0
TLS3_k127_1395764_73 CAAX protease self-immunity K07052 - - 0.000000000000000000000000001216 120.0
TLS3_k127_1395764_75 Putative prokaryotic signal transducing protein - - - 0.000000000000000000000198 100.0
TLS3_k127_1395764_76 cellulose binding K01179 - 3.2.1.4 0.00000000000000000008541 105.0
TLS3_k127_1395764_77 glucan 1,4-alpha-glucosidase activity K01178 - 3.2.1.3 0.00000000000000001497 85.0
TLS3_k127_1395764_78 gas vesicle protein - - - 0.0000000000000003878 81.0
TLS3_k127_1395764_79 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source K10778 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944 2.1.1.63 0.0000000000000004892 80.0
TLS3_k127_1395764_8 Type III restriction enzyme res subunit - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 1.985e-248 777.0
TLS3_k127_1395764_80 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000005978 89.0
TLS3_k127_1395764_81 DNA-binding transcription factor activity K03892 - - 0.00000000000005417 76.0
TLS3_k127_1395764_82 Domain of unknown function (DUF3817) - - - 0.0000000000002439 77.0
TLS3_k127_1395764_83 - - - - 0.000000000001204 75.0
TLS3_k127_1395764_84 NACHT domain - - - 0.00000000009898 74.0
TLS3_k127_1395764_87 PFAM Uncharacterised protein family UPF0150 - - - 0.000003079 51.0
TLS3_k127_1395764_88 WD-40 repeat - - - 0.000004398 58.0
TLS3_k127_1395764_89 PFAM Uncharacterised protein family UPF0150 - - - 0.00008218 50.0
TLS3_k127_1395764_9 exonuclease activity K16899 - 3.6.4.12 3.444e-245 792.0
TLS3_k127_1395764_91 Belongs to the peptidase S8 family - - - 0.0003288 48.0
TLS3_k127_1404217_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 5.807e-221 696.0
TLS3_k127_1404217_1 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 499.0
TLS3_k127_1404217_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.00000000000000000000000001808 115.0
TLS3_k127_1404217_11 - - - - 0.000000000006771 73.0
TLS3_k127_1404217_12 BON domain - - - 0.0005026 49.0
TLS3_k127_1404217_2 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 424.0
TLS3_k127_1404217_3 membrane protein (DUF2254) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 364.0
TLS3_k127_1404217_4 Alginate export - - - 0.000000000000000000000000000000000000000000000000000000000000000865 237.0
TLS3_k127_1404217_5 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000001035 224.0
TLS3_k127_1404217_6 COG3666 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000002836 223.0
TLS3_k127_1404217_7 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000007616 149.0
TLS3_k127_1404217_8 Hsp20/alpha crystallin family K13993 - - 0.000000000000000000000000000000000001142 145.0
TLS3_k127_1404217_9 - - - - 0.000000000000000000000000000002392 129.0
TLS3_k127_1488453_0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 291.0
TLS3_k127_1488453_1 COGs COG0790 FOG TPR repeat SEL1 subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001106 252.0
TLS3_k127_1488453_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000642 224.0
TLS3_k127_1488453_3 peptidase K02557,K21471 - - 0.00000000000000000000000000000000000000008328 171.0
TLS3_k127_1488453_4 Transposase - - - 0.0000000000002336 74.0
TLS3_k127_151723_0 CDP-glucose 4,6-dehydratase K01709 - 4.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007551 278.0
TLS3_k127_151723_1 Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3' - - - 0.000000000006074 68.0
TLS3_k127_151723_2 Transposase - - - 0.0000000003204 60.0
TLS3_k127_151723_3 Transposase - - - 0.00003922 47.0
TLS3_k127_1643958_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.0 1051.0
TLS3_k127_1643958_1 Glycosyl hydrolase family 1 K00067 - 1.1.1.133 2.476e-286 896.0
TLS3_k127_1643958_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000521 457.0
TLS3_k127_1643958_11 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 447.0
TLS3_k127_1643958_12 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 407.0
TLS3_k127_1643958_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 399.0
TLS3_k127_1643958_14 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 360.0
TLS3_k127_1643958_15 PFAM Ribonuclease BN-like family K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 316.0
TLS3_k127_1643958_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000608 296.0
TLS3_k127_1643958_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 284.0
TLS3_k127_1643958_18 oxidase, subunit K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004402 275.0
TLS3_k127_1643958_19 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000002559 250.0
TLS3_k127_1643958_2 Belongs to the glycosyl hydrolase 2 family - - - 4.67e-265 828.0
TLS3_k127_1643958_20 PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000003289 235.0
TLS3_k127_1643958_21 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000002615 203.0
TLS3_k127_1643958_22 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000001316 191.0
TLS3_k127_1643958_23 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000001179 164.0
TLS3_k127_1643958_24 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00330 - 1.6.5.3 0.000000000000000000000000000000001836 135.0
TLS3_k127_1643958_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000034 128.0
TLS3_k127_1643958_26 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000006442 110.0
TLS3_k127_1643958_27 Domain of unknown function (DUF2382) - - - 0.000000000000008489 83.0
TLS3_k127_1643958_28 Protein of unknown function (DUF1328) - - - 0.00000000001059 70.0
TLS3_k127_1643958_29 - - - - 0.00002221 51.0
TLS3_k127_1643958_3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 6.297e-225 714.0
TLS3_k127_1643958_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 - 1.6.5.3 1.484e-196 629.0
TLS3_k127_1643958_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 2.279e-194 615.0
TLS3_k127_1643958_6 Proton-conducting membrane transporter K00342 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 601.0
TLS3_k127_1643958_7 TIGRFAM UDP-galactopyranose mutase K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008899 589.0
TLS3_k127_1643958_8 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 496.0
TLS3_k127_1643958_9 galactose-1-phosphate uridylyltransferase K00965 GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008108,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0046914,GO:0070569,GO:0071704,GO:1901575 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 464.0
TLS3_k127_1657659_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0 1047.0
TLS3_k127_1657659_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 8.408e-300 931.0
TLS3_k127_1657659_10 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 544.0
TLS3_k127_1657659_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 487.0
TLS3_k127_1657659_12 epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 462.0
TLS3_k127_1657659_13 Cation efflux family K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 459.0
TLS3_k127_1657659_15 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 438.0
TLS3_k127_1657659_16 Arsenical pump membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 440.0
TLS3_k127_1657659_17 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 436.0
TLS3_k127_1657659_18 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 402.0
TLS3_k127_1657659_19 Nucleotidyl transferase K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 396.0
TLS3_k127_1657659_2 Nitroreductase - - - 3.415e-275 856.0
TLS3_k127_1657659_20 transferase activity, transferring hexosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 370.0
TLS3_k127_1657659_21 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 356.0
TLS3_k127_1657659_22 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 336.0
TLS3_k127_1657659_23 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008943 334.0
TLS3_k127_1657659_24 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 317.0
TLS3_k127_1657659_25 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 314.0
TLS3_k127_1657659_26 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00966,K00973,K00992 GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.24,2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000003812 264.0
TLS3_k127_1657659_27 Fungal family of unknown function (DUF1776) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000172 242.0
TLS3_k127_1657659_28 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000001431 235.0
TLS3_k127_1657659_29 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000001799 222.0
TLS3_k127_1657659_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.516e-250 780.0
TLS3_k127_1657659_30 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K00067,K01790 - 1.1.1.133,5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000002124 219.0
TLS3_k127_1657659_31 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000000000000000000000000000002304 213.0
TLS3_k127_1657659_32 Peptidase M15 K02395 - - 0.00000000000000000000000000000000000000000000000000000000107 207.0
TLS3_k127_1657659_33 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000000000000001406 207.0
TLS3_k127_1657659_34 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000000000000000000005305 199.0
TLS3_k127_1657659_35 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01991 - - 0.00000000000000000000000000000000000000000000000000000002426 203.0
TLS3_k127_1657659_36 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.0000000000000000000000000000000000000000000000000000001984 200.0
TLS3_k127_1657659_38 Bacterial protein of unknown function (DUF948) - - - 0.0000000000000000000000000000000000000000000000000004388 188.0
TLS3_k127_1657659_39 phosphorelay signal transduction system K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000001037 187.0
TLS3_k127_1657659_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 7.951e-243 756.0
TLS3_k127_1657659_40 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000113 169.0
TLS3_k127_1657659_41 Anti-sigma-K factor rskA K18682 - - 0.000000000000000000000000000000000000000000001481 173.0
TLS3_k127_1657659_44 - - - - 0.0000000000000000000000000000001245 136.0
TLS3_k127_1657659_46 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000003764 115.0
TLS3_k127_1657659_47 cell cycle K05589 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301,GO:0071944 - 0.000000000000000000000002587 106.0
TLS3_k127_1657659_49 Domain of unknown function (DUF4403) - - - 0.00000000000000000000004013 114.0
TLS3_k127_1657659_5 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 4.09e-241 749.0
TLS3_k127_1657659_50 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.00000000000000000002979 94.0
TLS3_k127_1657659_52 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000002513 85.0
TLS3_k127_1657659_53 Lipid A 3-O-deacylase (PagL) - - - 0.000000000000003248 83.0
TLS3_k127_1657659_55 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.000000004898 63.0
TLS3_k127_1657659_6 amino acid - - - 1.116e-234 736.0
TLS3_k127_1657659_7 Acts as a magnesium transporter K06213 - - 8.382e-226 707.0
TLS3_k127_1657659_8 Putative zinc binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006723 606.0
TLS3_k127_1657659_9 winged helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005514 603.0
TLS3_k127_1737003_0 C-terminal, D2-small domain, of ClpB protein K03696 - - 0.0 1497.0
TLS3_k127_1737003_1 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 7.568e-317 979.0
TLS3_k127_1737003_10 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 609.0
TLS3_k127_1737003_11 Catalyzes the conversion of dihydroorotate to orotate K00226,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 484.0
TLS3_k127_1737003_12 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 476.0
TLS3_k127_1737003_13 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009553 477.0
TLS3_k127_1737003_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 472.0
TLS3_k127_1737003_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 410.0
TLS3_k127_1737003_16 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004299 407.0
TLS3_k127_1737003_17 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 363.0
TLS3_k127_1737003_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 370.0
TLS3_k127_1737003_19 Evidence 2b Function of strongly homologous gene K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 357.0
TLS3_k127_1737003_2 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 2.222e-252 782.0
TLS3_k127_1737003_20 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 338.0
TLS3_k127_1737003_21 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 327.0
TLS3_k127_1737003_22 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 315.0
TLS3_k127_1737003_23 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 315.0
TLS3_k127_1737003_24 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007878 302.0
TLS3_k127_1737003_25 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 297.0
TLS3_k127_1737003_26 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 295.0
TLS3_k127_1737003_27 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006955 280.0
TLS3_k127_1737003_28 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006575 276.0
TLS3_k127_1737003_3 MacB-like periplasmic core domain K02004 - - 5.824e-250 797.0
TLS3_k127_1737003_30 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008504 257.0
TLS3_k127_1737003_31 MraZ protein, putative antitoxin-like K03925 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001654 246.0
TLS3_k127_1737003_32 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000003711 247.0
TLS3_k127_1737003_34 2 iron, 2 sulfur cluster binding K13643 - - 0.000000000000000000000000000000000000000000000000000000000000003474 219.0
TLS3_k127_1737003_35 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000000000009617 224.0
TLS3_k127_1737003_36 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000001706 196.0
TLS3_k127_1737003_37 Glycoprotease family K14742 - - 0.000000000000000000000000000000000000000000000000000001939 200.0
TLS3_k127_1737003_38 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000000000000004946 190.0
TLS3_k127_1737003_39 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000003553 183.0
TLS3_k127_1737003_4 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 4.698e-243 760.0
TLS3_k127_1737003_40 crossover junction endodeoxyribonuclease activity K01160 - 3.1.22.4 0.000000000000000000000000000000000000000000000008442 178.0
TLS3_k127_1737003_41 belongs to the thioredoxin family K14949,K20543 - 2.7.11.1 0.0000000000000000000000000000000000000000000001515 177.0
TLS3_k127_1737003_42 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000000002363 173.0
TLS3_k127_1737003_43 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000000000000000000009635 168.0
TLS3_k127_1737003_44 Cytochrome c - - - 0.00000000000000000000000000000000000000001954 157.0
TLS3_k127_1737003_46 PFAM Archease protein family (DUF101 UPF0211) - - - 0.0000000000000000000000000000000000000009418 153.0
TLS3_k127_1737003_47 Putative regulatory protein - - - 0.000000000000000000000000000009917 123.0
TLS3_k127_1737003_49 response regulator - - - 0.000000000000000000000004299 104.0
TLS3_k127_1737003_5 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 9.66e-240 746.0
TLS3_k127_1737003_50 Protein of unknown function (DUF465) K09794 - - 0.000000000000000000007046 94.0
TLS3_k127_1737003_53 Excisionase - - - 0.0000000004971 62.0
TLS3_k127_1737003_54 domain protein K20276 - - 0.00001431 55.0
TLS3_k127_1737003_55 Protein of unknown function (DUF3703) - - - 0.00002399 50.0
TLS3_k127_1737003_56 - - - - 0.0003133 43.0
TLS3_k127_1737003_6 'glutamate synthase K00528,K03388 - 1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 1.96e-228 713.0
TLS3_k127_1737003_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 2.347e-198 632.0
TLS3_k127_1737003_8 Metallopeptidase family M24 K01262 - 3.4.11.9 8.132e-197 619.0
TLS3_k127_1737003_9 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00322,K00382 - 1.6.1.1,1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 616.0
TLS3_k127_1737347_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1102.0
TLS3_k127_1737347_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0 1067.0
TLS3_k127_1737347_10 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 424.0
TLS3_k127_1737347_11 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 383.0
TLS3_k127_1737347_12 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 321.0
TLS3_k127_1737347_15 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000000000000001693 180.0
TLS3_k127_1737347_16 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000004098 147.0
TLS3_k127_1737347_18 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000000000003182 135.0
TLS3_k127_1737347_19 Protein conserved in bacteria K09764 - - 0.00000000000000000000000000000002458 128.0
TLS3_k127_1737347_2 polyribonucleotide nucleotidyltransferase activity K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 7.13e-247 780.0
TLS3_k127_1737347_20 Winged helix-turn helix K18996 - - 0.0000000001151 65.0
TLS3_k127_1737347_21 PFAM Integrase catalytic - - - 0.0000000001708 67.0
TLS3_k127_1737347_22 Transposase and inactivated derivatives - - - 0.00002387 48.0
TLS3_k127_1737347_23 PFAM Integrase catalytic region - - - 0.00008974 52.0
TLS3_k127_1737347_3 Aminotransferase class I and II K14261 - - 4.495e-237 736.0
TLS3_k127_1737347_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 4.989e-215 679.0
TLS3_k127_1737347_5 ACT domain K00928 - 2.7.2.4 3.691e-214 670.0
TLS3_k127_1737347_6 Homoserine dehydrogenase K00003 - 1.1.1.3 4.582e-210 661.0
TLS3_k127_1737347_7 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 588.0
TLS3_k127_1737347_8 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 529.0
TLS3_k127_1737347_9 Metalloenzyme superfamily K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 486.0
TLS3_k127_1784348_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1292.0
TLS3_k127_1784348_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1107.0
TLS3_k127_1784348_10 Cytochrome b/b6/petB K00412 - - 1.025e-207 653.0
TLS3_k127_1784348_11 Domain of unknown function (DUF3463) - - - 3.497e-207 646.0
TLS3_k127_1784348_12 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007486 566.0
TLS3_k127_1784348_13 rRNA (guanine-N2-)-methyltransferase activity K13604,K21460 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.304,2.1.1.333 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 567.0
TLS3_k127_1784348_14 Surface antigen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 562.0
TLS3_k127_1784348_15 heme binding K00463 - 1.13.11.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006439 550.0
TLS3_k127_1784348_16 oxidoreductase activity, acting on diphenols and related substances as donors K00240,K03886 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006332 505.0
TLS3_k127_1784348_17 Phosphate transporter family K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 478.0
TLS3_k127_1784348_18 Histidine kinase K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 422.0
TLS3_k127_1784348_19 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006732 415.0
TLS3_k127_1784348_2 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 0.0 1097.0
TLS3_k127_1784348_20 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 415.0
TLS3_k127_1784348_21 Cytochrome c K02305,K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 413.0
TLS3_k127_1784348_22 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 402.0
TLS3_k127_1784348_23 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009778 398.0
TLS3_k127_1784348_24 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 402.0
TLS3_k127_1784348_25 Ethylbenzene dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 383.0
TLS3_k127_1784348_26 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 380.0
TLS3_k127_1784348_27 Evidence 5 No homology to any previously reported sequences K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 400.0
TLS3_k127_1784348_28 His Kinase A (phosphoacceptor) domain K02484,K07636,K07768 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 389.0
TLS3_k127_1784348_29 Transcriptional regulatory protein, C terminal K07658 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 361.0
TLS3_k127_1784348_3 aerobic electron transport chain K00425,K08738 - 1.10.3.14 3.52e-321 991.0
TLS3_k127_1784348_30 Tetratricopeptide repeat K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008859 327.0
TLS3_k127_1784348_31 Protein of unknown function DUF47 K02039,K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 306.0
TLS3_k127_1784348_32 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 304.0
TLS3_k127_1784348_33 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 303.0
TLS3_k127_1784348_34 Cytochrome c K08738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 297.0
TLS3_k127_1784348_36 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008773 283.0
TLS3_k127_1784348_37 Cytochrome c K17052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003471 286.0
TLS3_k127_1784348_38 Histidine kinase K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000144 271.0
TLS3_k127_1784348_39 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000303 249.0
TLS3_k127_1784348_4 Histidine kinase K07638 - 2.7.13.3 5.353e-313 979.0
TLS3_k127_1784348_40 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004337 240.0
TLS3_k127_1784348_41 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000001451 234.0
TLS3_k127_1784348_42 cell redox homeostasis - - - 0.000000000000000000000000000000000000000000000000000000000002864 213.0
TLS3_k127_1784348_43 protein disulfide oxidoreductase activity K07390 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - 0.00000000000000000000000000000000000000000000000000000000002298 206.0
TLS3_k127_1784348_44 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000000000000003262 207.0
TLS3_k127_1784348_45 adenosylhomocysteine nucleosidase activity K01243,K03527 - 1.17.7.4,3.2.2.9 0.0000000000000000000000000000000000000000000000004205 185.0
TLS3_k127_1784348_47 - - - - 0.0000000000000000000000000000000000001451 147.0
TLS3_k127_1784348_48 domain, Protein K13735,K15125,K15531 - 3.2.1.156 0.000000000000000000000000000000000001149 151.0
TLS3_k127_1784348_5 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 5.867e-275 866.0
TLS3_k127_1784348_50 Belongs to the BolA IbaG family K05527,K22066 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - 0.0000000000000000000000000001314 116.0
TLS3_k127_1784348_51 Glycosyltransferase family 87 - - - 0.0000000000009935 80.0
TLS3_k127_1784348_52 Domain of unknown function (DUF1989) - - - 0.000000000002579 67.0
TLS3_k127_1784348_53 - - - - 0.00004116 48.0
TLS3_k127_1784348_55 - - - - 0.0001754 45.0
TLS3_k127_1784348_56 Protein of unknown function (DUF429) K09147 - - 0.0004742 44.0
TLS3_k127_1784348_6 aerobic electron transport chain K00425,K08738 - 1.10.3.14 2.766e-251 786.0
TLS3_k127_1784348_7 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 9.151e-240 745.0
TLS3_k127_1784348_8 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 8.506e-231 716.0
TLS3_k127_1784348_9 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 1.338e-217 679.0
TLS3_k127_180564_0 Chase2 domain K01768,K07315 - 3.1.3.3,4.6.1.1 6.608e-194 616.0
TLS3_k127_180564_1 Protein of unknown function (DUF3574) - - - 0.0000000000000000000000000000000283 131.0
TLS3_k127_180564_2 Transposase - - - 0.00000000002794 63.0
TLS3_k127_1829259_0 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0 1669.0
TLS3_k127_1829259_1 Sigma-54 interaction domain K07714 - - 7.527e-248 773.0
TLS3_k127_1829259_11 DnaJ domain - - - 0.000000000000693 77.0
TLS3_k127_1829259_12 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000009761 68.0
TLS3_k127_1829259_13 - - - - 0.00003376 53.0
TLS3_k127_1829259_2 His Kinase A (phosphoacceptor) domain - - - 4.755e-197 639.0
TLS3_k127_1829259_3 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 295.0
TLS3_k127_1829259_4 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000006794 220.0
TLS3_k127_1829259_5 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000002192 170.0
TLS3_k127_1829259_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000001734 134.0
TLS3_k127_1829259_7 antisigma factor binding K03598 - - 0.0000000000000000000000000000004374 129.0
TLS3_k127_1829259_8 - - - - 0.000000000000000000000000001131 123.0
TLS3_k127_1829259_9 protein maturation K07390,K13628,K15724 - - 0.00000000000000000114 89.0
TLS3_k127_1854339_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.813e-273 850.0
TLS3_k127_1854339_1 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 4.138e-241 750.0
TLS3_k127_1854339_10 Cytochrome c K00405 - - 0.000000000000000000000000000000000000000004939 160.0
TLS3_k127_1854339_11 Pfam:N_methyl_3 K02650 - - 0.0007427 42.0
TLS3_k127_1854339_2 Tetratricopeptide repeat - - - 1.438e-224 711.0
TLS3_k127_1854339_3 twitching motility protein K02670 - - 2.044e-209 655.0
TLS3_k127_1854339_4 Evidence 2b Function of strongly homologous gene - - - 1.053e-206 646.0
TLS3_k127_1854339_5 Type II/IV secretion system protein K02669 - - 1.819e-204 638.0
TLS3_k127_1854339_6 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 484.0
TLS3_k127_1854339_7 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 481.0
TLS3_k127_1854339_8 Histidyl-tRNA synthetase K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 432.0
TLS3_k127_1854339_9 cell envelope organization K05807,K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003139 269.0
TLS3_k127_1931682_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1328.0
TLS3_k127_1931682_1 Di-haem cytochrome c peroxidase - - - 3.55e-293 912.0
TLS3_k127_1931682_10 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000003865 225.0
TLS3_k127_1931682_11 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798,K04076,K13525,K17681 - 3.4.21.53 0.0000000000000000000000000000000000000000000000001492 184.0
TLS3_k127_1931682_12 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000008787 126.0
TLS3_k127_1931682_13 response regulator K07686,K07689,K20264 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000004773 116.0
TLS3_k127_1931682_14 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.000000000000000000000004229 103.0
TLS3_k127_1931682_15 response regulator - - - 0.0000000000000000000001132 107.0
TLS3_k127_1931682_16 - - - - 0.000000000747 64.0
TLS3_k127_1931682_17 Protein of unknown function (DUF421) - - - 0.000000002972 65.0
TLS3_k127_1931682_18 Domain of unknown function (DUF4145) - - - 0.000000009947 58.0
TLS3_k127_1931682_19 - - - - 0.00000001194 66.0
TLS3_k127_1931682_2 ATPase activity K01990 - - 4.145e-287 895.0
TLS3_k127_1931682_20 PFAM MgtC SapB transporter K07507 - - 0.00000003739 59.0
TLS3_k127_1931682_21 - - - - 0.000000114 55.0
TLS3_k127_1931682_22 His Kinase A (phosphoacceptor) domain - - - 0.00001293 55.0
TLS3_k127_1931682_3 HlyD family secretion protein K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009361 488.0
TLS3_k127_1931682_4 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 480.0
TLS3_k127_1931682_5 Acetokinase family K00925 - 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 461.0
TLS3_k127_1931682_6 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 441.0
TLS3_k127_1931682_7 Protein of unknown function (DUF1207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000234 276.0
TLS3_k127_1931682_8 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002099 264.0
TLS3_k127_1931682_9 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000249 236.0
TLS3_k127_2028343_0 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1962.0
TLS3_k127_2028343_1 dead DEAH box helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 1.283e-274 856.0
TLS3_k127_2028343_10 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 469.0
TLS3_k127_2028343_11 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 426.0
TLS3_k127_2028343_12 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 365.0
TLS3_k127_2028343_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 338.0
TLS3_k127_2028343_14 Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 336.0
TLS3_k127_2028343_15 deoxyhypusine monooxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000696 329.0
TLS3_k127_2028343_16 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 311.0
TLS3_k127_2028343_17 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 301.0
TLS3_k127_2028343_18 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007162 300.0
TLS3_k127_2028343_19 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 286.0
TLS3_k127_2028343_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K06147,K11085 - - 2.012e-253 796.0
TLS3_k127_2028343_20 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002957 283.0
TLS3_k127_2028343_21 nucleotidyltransferase activity K00984,K19279 - 2.7.7.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000005193 266.0
TLS3_k127_2028343_22 JAB/MPN domain K21140 - 3.13.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000002131 244.0
TLS3_k127_2028343_23 Domain of unknown function (DUF5069) - - - 0.000000000000000000000000000000000000000000000000000000000000003317 219.0
TLS3_k127_2028343_25 PLD-like domain - - - 0.000000000000000000000000000000000000000000000000000000002762 209.0
TLS3_k127_2028343_26 epimerase - - - 0.000000000000000000000000000000000000000000000000000003108 198.0
TLS3_k127_2028343_28 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000004363 187.0
TLS3_k127_2028343_29 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000003323 169.0
TLS3_k127_2028343_3 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 1.329e-248 769.0
TLS3_k127_2028343_30 - - - - 0.000000000000000000000000000000000000000001304 157.0
TLS3_k127_2028343_31 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000006315 163.0
TLS3_k127_2028343_32 ThiS family K03636 - - 0.0000000000000000000000000000000000000001147 151.0
TLS3_k127_2028343_34 nitric oxide reductase activity K03809 - 1.6.5.2 0.00000000000000000000000000000000000465 139.0
TLS3_k127_2028343_35 Protein of unknown function (DUF2442) - - - 0.000000000000000000000000000000001987 135.0
TLS3_k127_2028343_36 NIL - - - 0.000000000000000000000000000000005006 130.0
TLS3_k127_2028343_38 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 - 0.00000000000000000000000000002571 119.0
TLS3_k127_2028343_4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 5.861e-225 702.0
TLS3_k127_2028343_40 Regulatory protein, FmdB family - - - 0.000000000000000000000000002388 112.0
TLS3_k127_2028343_42 thiamine diphosphate biosynthetic process K03154 - - 0.000000000000000000000000212 106.0
TLS3_k127_2028343_44 Protein of unknown function (DUF2283) - - - 0.0000000000000000000002603 98.0
TLS3_k127_2028343_46 dead DEAH box helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000009368 94.0
TLS3_k127_2028343_5 TonB-dependent receptor K02014 - - 3.654e-224 712.0
TLS3_k127_2028343_51 hydrolase activity, acting on ester bonds - - - 0.0000000000003019 70.0
TLS3_k127_2028343_52 TIGRFAM Addiction module toxin, RelE StbE K06218 - - 0.000000000003232 69.0
TLS3_k127_2028343_53 toxin-antitoxin pair type II binding K19159 - - 0.000000000009172 68.0
TLS3_k127_2028343_54 DDE superfamily endonuclease - - - 0.00000000006374 66.0
TLS3_k127_2028343_55 - - - - 0.0000000004921 60.0
TLS3_k127_2028343_57 DSBA-like thioredoxin domain - - - 0.0000076 51.0
TLS3_k127_2028343_58 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000008518 54.0
TLS3_k127_2028343_59 - - - - 0.00002182 49.0
TLS3_k127_2028343_6 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 561.0
TLS3_k127_2028343_60 PFAM Uncharacterised protein family UPF0150 - - - 0.0000931 46.0
TLS3_k127_2028343_61 PFAM plasmid stabilization system K06218 - - 0.0009165 42.0
TLS3_k127_2028343_7 Pyridoxal-phosphate dependent enzyme K01738,K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 547.0
TLS3_k127_2028343_8 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 496.0
TLS3_k127_2028343_9 ThiF family K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 482.0
TLS3_k127_2041826_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005833 277.0
TLS3_k127_2041826_2 Protein of unknown function, DUF488 - - - 0.000000000000003734 81.0
TLS3_k127_2044568_0 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.0 2309.0
TLS3_k127_2044568_1 ATP-grasp domain K01905,K22224 - 6.2.1.13 0.0 1175.0
TLS3_k127_2044568_10 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000001052 204.0
TLS3_k127_2044568_11 ABC-type transport auxiliary lipoprotein component K18480 - - 0.000000000000000000000000000000000000000000000000000005572 196.0
TLS3_k127_2044568_12 hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000399 185.0
TLS3_k127_2044568_13 Copper/zinc superoxide dismutase (SODC) K04565 - 1.15.1.1 0.00000000000000000000000000000000000005792 149.0
TLS3_k127_2044568_14 - - - - 0.00000000000000000000000000000002254 128.0
TLS3_k127_2044568_15 Cytochrome c K02305,K17223 - - 0.000000000000000000000000000002229 125.0
TLS3_k127_2044568_16 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000000000000004627 129.0
TLS3_k127_2044568_17 Belongs to the P-Pant transferase superfamily K06133 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000005954 120.0
TLS3_k127_2044568_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K12263 - - 0.00000000000000000000000002924 115.0
TLS3_k127_2044568_2 Cytochrome c K12263 - - 1.128e-241 752.0
TLS3_k127_2044568_20 Cytochrome c K12263 - - 0.0000000000000000000000001591 110.0
TLS3_k127_2044568_21 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000001692 106.0
TLS3_k127_2044568_22 Cytochrome c K12263 - - 0.0000000000000000000004817 99.0
TLS3_k127_2044568_24 - - - - 0.0000000000000000007982 96.0
TLS3_k127_2044568_25 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000001675 64.0
TLS3_k127_2044568_3 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006898 375.0
TLS3_k127_2044568_4 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 337.0
TLS3_k127_2044568_5 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005043 249.0
TLS3_k127_2044568_6 iron ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000003043 237.0
TLS3_k127_2044568_7 cellular manganese ion homeostasis - - - 0.0000000000000000000000000000000000000000000000000000000000000007593 222.0
TLS3_k127_2044568_8 OsmC-like protein K09136 - - 0.000000000000000000000000000000000000000000000000000000000001452 211.0
TLS3_k127_2044568_9 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE K06039,K07235 - - 0.000000000000000000000000000000000000000000000000000000000002425 210.0
TLS3_k127_2322531_0 siderophore transport K02014 - - 0.0 1133.0
TLS3_k127_2322531_1 transmembrane transporter activity K18138 - - 0.0 1035.0
TLS3_k127_2322531_10 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000002296 124.0
TLS3_k127_2322531_11 COG0457 FOG TPR repeat - - - 0.00000000000000000000000007346 113.0
TLS3_k127_2322531_12 energy transducer activity K03832 - - 0.0000000000000000000000007486 114.0
TLS3_k127_2322531_13 receptor K02014 - - 0.000000000000000002199 91.0
TLS3_k127_2322531_14 PFAM Plasmid stabilisation system protein - - - 0.0000000000000001375 81.0
TLS3_k127_2322531_16 DDE superfamily endonuclease - - - 0.0000000004214 60.0
TLS3_k127_2322531_17 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K03832 - - 0.0000315 50.0
TLS3_k127_2322531_18 TIGRFAM molybdenum cofactor synthesis K07219 - - 0.00004023 50.0
TLS3_k127_2322531_2 Iron permease FTR1 family K07243 - - 2.582e-284 887.0
TLS3_k127_2322531_3 efflux transmembrane transporter activity K12340 - - 7.448e-221 696.0
TLS3_k127_2322531_4 Iron-regulated membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 413.0
TLS3_k127_2322531_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003832 279.0
TLS3_k127_2322531_6 iron ion homeostasis K07165 - - 0.00000000000000000000000000000000000000000000000000000144 204.0
TLS3_k127_2322531_8 DNA integration K14059 - - 0.000000000000000000000000000000000006649 151.0
TLS3_k127_2322531_9 Represses a number of genes involved in the response to DNA damage (SOS response) K01356 - 3.4.21.88 0.000000000000000000000000000000000008333 139.0
TLS3_k127_240790_0 B12 binding domain - - - 1.004e-299 925.0
TLS3_k127_240790_1 radical SAM domain protein - - - 6.594e-273 857.0
TLS3_k127_240790_10 lipid binding K03098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001762 263.0
TLS3_k127_240790_11 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000003333 239.0
TLS3_k127_240790_12 Integrase core domain - - - 0.00000000000000000000000000000000000000000000000000000000008837 214.0
TLS3_k127_240790_13 Belongs to the HesB IscA family K15724 - - 0.000000000000000000000000000000000000000000000000000001801 195.0
TLS3_k127_240790_15 membrane protein of uknown function UCP014873 - - - 0.0000000000000000000000000000000000000000000000001692 182.0
TLS3_k127_240790_16 protein disulfide oxidoreductase activity K03673 - - 0.0000000000000000000000000000000000000000000000002319 182.0
TLS3_k127_240790_17 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000000000005837 182.0
TLS3_k127_240790_18 - - - - 0.00000000000000000000000000000000001031 142.0
TLS3_k127_240790_2 Vitamin K epoxide reductase family - - - 2.992e-239 762.0
TLS3_k127_240790_21 PFAM Integrase, catalytic region - - - 0.000000000000000000000000000002415 121.0
TLS3_k127_240790_22 AAA ATPase domain - - - 0.00000000000000000000000000002183 129.0
TLS3_k127_240790_24 - - - - 0.000000000000000000000001775 110.0
TLS3_k127_240790_25 Flagellar basal body rod FlgEFG protein C-terminal K02388 - - 0.0000000000000000000764 93.0
TLS3_k127_240790_26 UPF0391 membrane protein - - - 0.000000000000002055 78.0
TLS3_k127_240790_28 Belongs to the UPF0337 (CsbD) family - - - 0.00000000000006845 74.0
TLS3_k127_240790_29 Superinfection immunity protein - - - 0.000000000001993 68.0
TLS3_k127_240790_3 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 8.962e-228 709.0
TLS3_k127_240790_30 Protein of unknown function (DUF1328) - - - 0.000000000006925 66.0
TLS3_k127_240790_32 Glucose-6-phosphate dehydrogenase, NAD binding domain K00036 - 1.1.1.363,1.1.1.49 0.0000000008987 62.0
TLS3_k127_240790_33 Transposase and inactivated derivatives K18320 - - 0.000000005114 58.0
TLS3_k127_240790_34 Protein of unknown function (DUF1328) - - - 0.00000001381 57.0
TLS3_k127_240790_35 short chain amide porin - - - 0.0000001389 53.0
TLS3_k127_240790_36 - - - - 0.0000001777 56.0
TLS3_k127_240790_37 Periplasmic or secreted lipoprotein K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.0000005074 56.0
TLS3_k127_240790_38 bacterial OsmY and nodulation domain K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.00003613 50.0
TLS3_k127_240790_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 558.0
TLS3_k127_240790_40 - - - - 0.0002626 45.0
TLS3_k127_240790_5 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 391.0
TLS3_k127_240790_6 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 355.0
TLS3_k127_240790_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20974 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 350.0
TLS3_k127_240790_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 303.0
TLS3_k127_240790_9 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003295 273.0
TLS3_k127_2436756_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 6.37e-322 992.0
TLS3_k127_2436756_1 Belongs to the carbamoyltransferase HypF family K04656 - - 2.345e-229 737.0
TLS3_k127_2436756_10 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 314.0
TLS3_k127_2436756_11 AMP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004134 282.0
TLS3_k127_2436756_12 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002154 268.0
TLS3_k127_2436756_13 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002689 252.0
TLS3_k127_2436756_14 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001327 261.0
TLS3_k127_2436756_15 response regulator K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002059 251.0
TLS3_k127_2436756_16 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002316 246.0
TLS3_k127_2436756_18 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000008624 205.0
TLS3_k127_2436756_19 response regulator K02479,K07684,K07685 - - 0.000000000000000000000000000000000000000001089 164.0
TLS3_k127_2436756_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00162,K11381 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 556.0
TLS3_k127_2436756_20 PFAM OmpA MotB domain protein K03640 - - 0.000000000000000000000000000000001074 138.0
TLS3_k127_2436756_21 Hydrogenase maturation protease - - - 0.00000000000000000000000000001582 123.0
TLS3_k127_2436756_22 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.000000000000000000000000006264 116.0
TLS3_k127_2436756_23 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K12263 - - 0.0000000000000000000000008736 104.0
TLS3_k127_2436756_24 Diguanylate cyclase phosphodiesterase - - - 0.000000000000000000001663 108.0
TLS3_k127_2436756_25 HupF/HypC family K04653 - - 0.0000000000000002222 79.0
TLS3_k127_2436756_26 peptidase - - - 0.00000000000003822 78.0
TLS3_k127_2436756_27 - - - - 0.00000001525 60.0
TLS3_k127_2436756_29 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000001737 56.0
TLS3_k127_2436756_3 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004332 546.0
TLS3_k127_2436756_4 Nickel-dependent hydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 539.0
TLS3_k127_2436756_5 S-acyltransferase activity K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008371 512.0
TLS3_k127_2436756_6 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K00162,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007496 486.0
TLS3_k127_2436756_7 4Fe-4S dicluster domain K16950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 415.0
TLS3_k127_2436756_8 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 357.0
TLS3_k127_2436756_9 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007721 323.0
TLS3_k127_2633421_0 Arginase family K01480 - 3.5.3.11 1.595e-212 664.0
TLS3_k127_2633421_1 acr, cog1565 K00412,K00971,K02275,K02389,K03177,K17624 - 1.9.3.1,2.7.7.13,3.2.1.97,5.4.99.25 1.49e-203 643.0
TLS3_k127_2633421_2 Protein involved in outer membrane biogenesis K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 606.0
TLS3_k127_2633421_3 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000001968 228.0
TLS3_k127_2633421_4 PFAM Cupin - - - 0.0000000000000000000000000000000000000000000000007484 177.0
TLS3_k127_2633421_5 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.000000000000000000000000000000000000000001489 164.0
TLS3_k127_2633421_6 Domain of unknown function (DUF2382) - - - 0.00000000000004522 79.0
TLS3_k127_2633421_8 cellular water homeostasis K03442,K22044 - - 0.0000006902 57.0
TLS3_k127_2667200_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0 1391.0
TLS3_k127_2667200_1 EcoEI R protein C-terminal K01153 - 3.1.21.3 0.0 1309.0
TLS3_k127_2667200_10 Histidine kinase-like ATPase domain K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 354.0
TLS3_k127_2667200_11 reverse transcriptase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000428 323.0
TLS3_k127_2667200_12 Type I restriction modification DNA specificity domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 305.0
TLS3_k127_2667200_13 Thi4 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 293.0
TLS3_k127_2667200_14 Peptidase membrane zinc metallopeptidase K06973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003461 261.0
TLS3_k127_2667200_15 PFAM Excinuclease ABC C subunit domain protein K07461 - - 0.000000000000000000000000000000000000001424 153.0
TLS3_k127_2667200_16 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000009544 155.0
TLS3_k127_2667200_17 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000000000000000001384 139.0
TLS3_k127_2667200_18 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000214 143.0
TLS3_k127_2667200_19 nuclease activity K18828 - - 0.00000000000000000000000000000005551 128.0
TLS3_k127_2667200_2 iron-nicotianamine transmembrane transporter activity - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 3.102e-247 780.0
TLS3_k127_2667200_20 - K21495 - - 0.0000000000000000000003296 99.0
TLS3_k127_2667200_23 transporter antisigma-factor antagonist STAS K04749 - - 0.00000000000009308 76.0
TLS3_k127_2667200_24 - - - - 0.000000000002609 78.0
TLS3_k127_2667200_26 Putative addiction module component - - - 0.000002425 55.0
TLS3_k127_2667200_3 helicase activity K05592 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0032574,GO:0032575,GO:0033554,GO:0033592,GO:0034057,GO:0034248,GO:0034250,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 1.398e-245 775.0
TLS3_k127_2667200_4 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006028 564.0
TLS3_k127_2667200_5 HsdM N-terminal domain K03427 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005264 470.0
TLS3_k127_2667200_6 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009883 469.0
TLS3_k127_2667200_7 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 451.0
TLS3_k127_2667200_8 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 402.0
TLS3_k127_2667200_9 N-6 DNA Methylase K03427 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 356.0
TLS3_k127_2670000_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.611e-260 815.0
TLS3_k127_2670000_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009805 544.0
TLS3_k127_2670000_10 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000000000000000000000000008247 200.0
TLS3_k127_2670000_11 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000003628 183.0
TLS3_k127_2670000_12 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.00000000000000000000000000000000000000000000000006611 179.0
TLS3_k127_2670000_15 CBS-domain-containing membrane protein K07168 - - 0.00000000000003669 81.0
TLS3_k127_2670000_2 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 414.0
TLS3_k127_2670000_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 351.0
TLS3_k127_2670000_4 branched-chain-amino-acid transaminase activity K00824 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006713 353.0
TLS3_k127_2670000_5 inositol monophosphate 1-phosphatase activity K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000319 262.0
TLS3_k127_2670000_6 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001431 252.0
TLS3_k127_2670000_8 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002122 241.0
TLS3_k127_2670000_9 MEKHLA domain - - - 0.000000000000000000000000000000000000000000000000000000006524 206.0
TLS3_k127_2771080_0 Glycine cleavage system P-protein K00281,K00283 - 1.4.4.2 0.0 1527.0
TLS3_k127_2771080_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 3.651e-249 772.0
TLS3_k127_2771080_10 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 517.0
TLS3_k127_2771080_11 Class V aminotransferase K04127 - 5.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 464.0
TLS3_k127_2771080_12 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008098 442.0
TLS3_k127_2771080_13 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 390.0
TLS3_k127_2771080_14 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008675 390.0
TLS3_k127_2771080_15 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 348.0
TLS3_k127_2771080_16 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 344.0
TLS3_k127_2771080_17 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 323.0
TLS3_k127_2771080_18 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 304.0
TLS3_k127_2771080_19 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004359 288.0
TLS3_k127_2771080_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 1.482e-227 710.0
TLS3_k127_2771080_21 protein secretion K03116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009958 254.0
TLS3_k127_2771080_22 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000413 244.0
TLS3_k127_2771080_23 PilZ domain K02676 - - 0.000000000000000000000000000000000000000000000000000000000001224 214.0
TLS3_k127_2771080_24 PilZ domain K02676 - - 0.000000000000000000000000000000000000000000000000000000000002162 214.0
TLS3_k127_2771080_25 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000000000000000001048 218.0
TLS3_k127_2771080_26 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000000000002754 170.0
TLS3_k127_2771080_27 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000000000000000000003503 159.0
TLS3_k127_2771080_29 Sel1-like repeats. - - - 0.00000000000000000000000000006441 123.0
TLS3_k127_2771080_3 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 9.778e-227 709.0
TLS3_k127_2771080_30 Domain of unknown function (DUF4258) - - - 0.00000000000000008147 81.0
TLS3_k127_2771080_31 methyltransferase - - - 0.000000000000005608 85.0
TLS3_k127_2771080_32 TupA-like ATPgrasp - - - 0.0000000000001012 80.0
TLS3_k127_2771080_34 - - - - 0.000009598 49.0
TLS3_k127_2771080_36 PFAM PKD domain - - - 0.00008342 56.0
TLS3_k127_2771080_38 Domain of unknown function (DUF4258) - - - 0.0007318 42.0
TLS3_k127_2771080_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 6.684e-225 704.0
TLS3_k127_2771080_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 5.466e-218 691.0
TLS3_k127_2771080_6 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 4.751e-211 665.0
TLS3_k127_2771080_7 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 1.945e-198 632.0
TLS3_k127_2771080_8 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 597.0
TLS3_k127_2771080_9 proline dipeptidase activity K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006799 568.0
TLS3_k127_2778664_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1388.0
TLS3_k127_2778664_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1222.0
TLS3_k127_2778664_10 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 417.0
TLS3_k127_2778664_11 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 413.0
TLS3_k127_2778664_12 DnaJ central domain K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009872 407.0
TLS3_k127_2778664_13 Belongs to the sirtuin family. Class K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 369.0
TLS3_k127_2778664_14 phosphopentomutase activity K01839 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008844 368.0
TLS3_k127_2778664_15 Photosynthesis system II assembly factor YCF48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006667 359.0
TLS3_k127_2778664_16 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 345.0
TLS3_k127_2778664_17 to Cytochrome c-554 precursor (C554) (Hydroxylamine oxidoreductase-linked cytochrome) pir A59036 cytochrome c554, tetraheme, precursor - Nitrosomonas europaea - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 338.0
TLS3_k127_2778664_18 deoxyribose-phosphate aldolase activity K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 329.0
TLS3_k127_2778664_19 phosphatase activity K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 328.0
TLS3_k127_2778664_2 Heat shock 70 kDa protein K04043 - - 0.0 1112.0
TLS3_k127_2778664_20 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006065 307.0
TLS3_k127_2778664_21 Response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000026 290.0
TLS3_k127_2778664_22 spectrin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004769 292.0
TLS3_k127_2778664_23 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000000000000000000000000007152 251.0
TLS3_k127_2778664_24 response regulator K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000004194 232.0
TLS3_k127_2778664_25 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000003992 225.0
TLS3_k127_2778664_26 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000004497 224.0
TLS3_k127_2778664_27 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000000000000001462 209.0
TLS3_k127_2778664_28 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000000000001678 192.0
TLS3_k127_2778664_29 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000000000000000000000275 190.0
TLS3_k127_2778664_3 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase - - - 2.77e-322 1006.0
TLS3_k127_2778664_30 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000005215 201.0
TLS3_k127_2778664_32 toxin-antitoxin pair type II binding K08591,K19159 GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141 2.3.1.15 0.0000000000000000000000000000000000000000000000609 171.0
TLS3_k127_2778664_33 response regulator K02479,K07684,K07685 - - 0.000000000000000000000000000000000000003031 156.0
TLS3_k127_2778664_34 Domain of unknown function (DUF697) - - - 0.0000000000000000000000000000009952 134.0
TLS3_k127_2778664_35 regulation of DNA repair K03565,K19002 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 0.00000000000000000000000001335 116.0
TLS3_k127_2778664_36 protein localization to T-tubule K10380 - - 0.000000000000000000002177 101.0
TLS3_k127_2778664_37 - - - - 0.00000000000000002037 86.0
TLS3_k127_2778664_38 - - - - 0.00000000000001624 85.0
TLS3_k127_2778664_39 peptidase - - - 0.000000000000134 76.0
TLS3_k127_2778664_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 3.535e-219 686.0
TLS3_k127_2778664_40 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.000000000003312 67.0
TLS3_k127_2778664_41 nuclease activity K06218 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000284 66.0
TLS3_k127_2778664_42 Domain of unknown function (DUF4142) K08995 - - 0.0000000001237 69.0
TLS3_k127_2778664_44 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00001309 53.0
TLS3_k127_2778664_5 guanyl-nucleotide exchange factor activity - - - 7.608e-216 684.0
TLS3_k127_2778664_6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 580.0
TLS3_k127_2778664_7 Competence-damaged protein K03742,K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 494.0
TLS3_k127_2778664_8 UPF0365 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 466.0
TLS3_k127_2778664_9 peroxidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 435.0
TLS3_k127_2797629_0 non-ribosomal peptide synthetase - - - 0.0 3082.0
TLS3_k127_2797629_1 D-alanine [D-alanyl carrier protein] ligase activity K21183 GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0005991,GO:0006082,GO:0006629,GO:0006643,GO:0006664,GO:0006790,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009311,GO:0009987,GO:0016409,GO:0016740,GO:0016746,GO:0016747,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044262,GO:0044272,GO:0044281,GO:0046467,GO:0046505,GO:0046506,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0 2658.0
TLS3_k127_2797629_10 microcin transport K06160 - - 4.063e-210 668.0
TLS3_k127_2797629_11 denitrification pathway - - - 3.163e-207 651.0
TLS3_k127_2797629_12 ATP synthase alpha/beta family, beta-barrel domain K02412 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 603.0
TLS3_k127_2797629_13 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 451.0
TLS3_k127_2797629_14 FliG middle domain K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 443.0
TLS3_k127_2797629_15 Bacterial regulatory protein, Fis family K10943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 423.0
TLS3_k127_2797629_16 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 426.0
TLS3_k127_2797629_17 phosphorelay sensor kinase activity K07708,K07710,K10942 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009949 385.0
TLS3_k127_2797629_18 Thioesterase involved in non-ribosomal peptide biosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 302.0
TLS3_k127_2797629_19 Pfam SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001343 284.0
TLS3_k127_2797629_2 D-alanine [D-alanyl carrier protein] ligase activity K21183 GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0005991,GO:0006082,GO:0006629,GO:0006643,GO:0006664,GO:0006790,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009311,GO:0009987,GO:0016409,GO:0016740,GO:0016746,GO:0016747,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044262,GO:0044272,GO:0044281,GO:0046467,GO:0046505,GO:0046506,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0 2286.0
TLS3_k127_2797629_20 Belongs to the flagella basal body rod proteins family K02388 - - 0.000000000000000000000000000000000000000000000000000000000000000000005898 237.0
TLS3_k127_2797629_21 phosphorelay signal transduction system K02411,K03223,K03413 - - 0.000000000000000000000000000000000000000000000000000000000000004206 229.0
TLS3_k127_2797629_22 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000000000000000000000000000000000000000174 181.0
TLS3_k127_2797629_23 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000000000000003224 154.0
TLS3_k127_2797629_24 MbtH-like protein K05375 - - 0.000000000000000000000000000000001237 130.0
TLS3_k127_2797629_25 Fic/DOC family K07341 - - 0.0000000000000000000000000000003355 126.0
TLS3_k127_2797629_26 Flagellar hook-basal body complex protein FliE K02408 - - 0.0000000000000000000000004623 108.0
TLS3_k127_2797629_27 Methyltransferase domain - - - 0.000000000000000000000001321 113.0
TLS3_k127_2797629_28 PFAM SpoVT AbrB K07172,K18842 - - 0.00000000000004952 75.0
TLS3_k127_2797629_29 - - - - 0.00000008862 60.0
TLS3_k127_2797629_3 O-methyltransferase activity - - - 0.0 1745.0
TLS3_k127_2797629_30 DDE superfamily endonuclease - - - 0.000004319 50.0
TLS3_k127_2797629_4 AMP-binding enzyme C-terminal domain - - - 0.0 1587.0
TLS3_k127_2797629_5 synthase - - - 0.0 1561.0
TLS3_k127_2797629_6 antibiotic biosynthetic process K01434 - 3.5.1.11 3.186e-290 915.0
TLS3_k127_2797629_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00836 - 2.6.1.76 4.008e-219 687.0
TLS3_k127_2797629_8 The M ring may be actively involved in energy transduction K02409 - - 3.147e-215 679.0
TLS3_k127_2797629_9 phosphorelay signal transduction system K10941 - - 8.67e-214 674.0
TLS3_k127_2826366_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1052.0
TLS3_k127_2826366_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0 1002.0
TLS3_k127_2826366_10 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000004305 218.0
TLS3_k127_2826366_11 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.0000000000000000000000000000000000000000000000001244 178.0
TLS3_k127_2826366_12 DDE superfamily endonuclease - - - 0.0000000009374 59.0
TLS3_k127_2826366_2 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 4.447e-205 643.0
TLS3_k127_2826366_3 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 496.0
TLS3_k127_2826366_4 DAHP synthetase I family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007261 457.0
TLS3_k127_2826366_5 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 456.0
TLS3_k127_2826366_6 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009748 347.0
TLS3_k127_2826366_7 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004294 280.0
TLS3_k127_2826366_8 depolymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001212 257.0
TLS3_k127_2826366_9 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000001982 241.0
TLS3_k127_2835464_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 413.0
TLS3_k127_2835464_1 COG0655 Multimeric flavodoxin WrbA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 397.0
TLS3_k127_2835464_2 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 308.0
TLS3_k127_2835464_3 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000002794 218.0
TLS3_k127_2835464_4 Kelch repeat protein - - - 0.00000000000000000000000000002969 122.0
TLS3_k127_2835464_5 Winged helix-turn helix - - - 0.00000000000000000000001104 101.0
TLS3_k127_2835464_6 - - - - 0.0000000000000000000004713 100.0
TLS3_k127_2835464_7 protein y4pE y4sA - - - 0.0000000000000006238 77.0
TLS3_k127_2835464_8 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - 0.0001147 45.0
TLS3_k127_2930706_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 1.457e-283 875.0
TLS3_k127_2930706_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 6.961e-235 740.0
TLS3_k127_2930706_2 Secretin and TonB N terminus short domain K02666 - - 1.26e-214 681.0
TLS3_k127_2930706_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 418.0
TLS3_k127_2930706_4 (ABC) transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 402.0
TLS3_k127_2930706_5 signal-transduction protein containing cAMP-binding and CBS domains K02342,K05847,K07182 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 304.0
TLS3_k127_2930706_6 Nitrogen regulatory protein P-II K04751,K04752 - - 0.000000000000000000000000000000000000000000000000000002148 194.0
TLS3_k127_2930706_7 - - - - 0.00001881 53.0
TLS3_k127_3041876_0 Alpha amylase, catalytic domain K00700,K01236 - 2.4.1.18,3.2.1.141 0.0 1104.0
TLS3_k127_3041876_1 - - - - 6.956e-266 829.0
TLS3_k127_3041876_10 nuclease - - - 0.0000000000000000000000004601 112.0
TLS3_k127_3041876_11 Protein of unknown function (DUF2442) - - - 0.0000000000000000000000006354 110.0
TLS3_k127_3041876_12 - - - - 0.000000000000000000000001916 102.0
TLS3_k127_3041876_2 Aminotransferase class-III K01845 - 5.4.3.8 2.964e-206 649.0
TLS3_k127_3041876_3 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 400.0
TLS3_k127_3041876_4 (Barnase) inhibitor - - - 0.00000000000000000000000000000000000000003048 158.0
TLS3_k127_3041876_6 - - - - 0.0000000000000000000000000000000003906 141.0
TLS3_k127_3041876_7 endoribonuclease activity K03628,K15125 GO:0005575,GO:0005576 - 0.00000000000000000000000000000122 121.0
TLS3_k127_3392010_0 Animal haem peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 477.0
TLS3_k127_3392010_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) K00322 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 472.0
TLS3_k127_3392010_2 Tim44 K15539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 366.0
TLS3_k127_3392010_3 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000000000000000001782 149.0
TLS3_k127_3392010_5 - - - - 0.00000000000277 72.0
TLS3_k127_3392010_7 Methyltransferase domain K00598 - 2.1.1.144 0.000005658 49.0
TLS3_k127_340319_0 Common central domain of tyrosinase K00505 - 1.14.18.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 422.0
TLS3_k127_340319_1 PIN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004455 231.0
TLS3_k127_340319_2 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000001099 154.0
TLS3_k127_340319_3 response regulator K02479,K07684,K07685 - - 0.000000000000000000000000000000000001898 147.0
TLS3_k127_340319_4 - - - - 0.000000000000000000003129 97.0
TLS3_k127_340319_5 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000000008317 85.0
TLS3_k127_340319_6 - - - - 0.00000000000001901 81.0
TLS3_k127_340319_7 - - - - 0.00000000002273 66.0
TLS3_k127_3466515_0 obsolete transcription factor activity, core RNA polymerase II binding K06959 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - 0.0 1187.0
TLS3_k127_3466515_1 protein secretion by the type I secretion system K11004 - - 0.0 1063.0
TLS3_k127_3466515_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000433 423.0
TLS3_k127_3466515_11 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.5.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 370.0
TLS3_k127_3466515_12 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0097159,GO:0097367,GO:0098656,GO:0099133,GO:1901265,GO:1901363 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 359.0
TLS3_k127_3466515_13 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 340.0
TLS3_k127_3466515_14 PBP superfamily domain K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 328.0
TLS3_k127_3466515_15 thioredoxin peroxidase activity K11065 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 307.0
TLS3_k127_3466515_16 molybdate abc transporter K02018,K15496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 292.0
TLS3_k127_3466515_17 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001308 298.0
TLS3_k127_3466515_18 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008572 270.0
TLS3_k127_3466515_19 ABC transporter, periplasmic molybdate-binding protein K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.0000000000000000000000000000000000000000000000000000000000000000000000005056 253.0
TLS3_k127_3466515_2 Conserved carboxylase domain K01960 - 6.4.1.1 0.0 1016.0
TLS3_k127_3466515_20 Represses a number of genes involved in the response to DNA damage (SOS response) K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000001166 237.0
TLS3_k127_3466515_21 cysteine-type peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000002636 216.0
TLS3_k127_3466515_23 sequence-specific DNA binding - - - 0.0000000000000000000000000000000006623 135.0
TLS3_k127_3466515_24 Plasmid stabilization system K19092 - - 0.0000000000000000000000000000000007154 132.0
TLS3_k127_3466515_26 phosphorelay signal transduction system K02535 - 3.5.1.108 0.0000000000000000000000004376 109.0
TLS3_k127_3466515_27 identical protein binding K07285 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - 0.00000000000000001167 90.0
TLS3_k127_3466515_3 Biotin carboxylase C-terminal domain K01959 - 6.4.1.1 1.723e-267 828.0
TLS3_k127_3466515_30 identical protein binding K07285 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - 0.000000000001581 76.0
TLS3_k127_3466515_31 molybdate ion transport K02019 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 - 0.00000000002061 69.0
TLS3_k127_3466515_32 identical protein binding K07285 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - 0.0000000003886 70.0
TLS3_k127_3466515_33 - - - - 0.000000007226 61.0
TLS3_k127_3466515_35 short chain amide porin - - - 0.0001668 44.0
TLS3_k127_3466515_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.794e-266 826.0
TLS3_k127_3466515_5 4-alpha-glucanotransferase K00705 - 2.4.1.25 2.752e-260 824.0
TLS3_k127_3466515_6 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00322,K00382 - 1.6.1.1,1.8.1.4 2.929e-224 703.0
TLS3_k127_3466515_7 Sigma-54 interaction domain K07714 - - 1.686e-214 674.0
TLS3_k127_3466515_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02022,K11003,K12532 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 609.0
TLS3_k127_3466515_9 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008823 448.0
TLS3_k127_3493533_0 TonB-dependent receptor K16091 - - 0.0 1019.0
TLS3_k127_3503969_0 deoxyhypusine monooxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 438.0
TLS3_k127_3503969_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 381.0
TLS3_k127_3503969_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000000000000000000000002155 223.0
TLS3_k127_3503969_3 Protein of unknown function (DUF1810) - - - 0.0000000000000000000000000000000000000000000000002908 179.0
TLS3_k127_3503969_4 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000000000000000000001369 107.0
TLS3_k127_3503969_5 sequence-specific DNA binding - - - 0.00000000000000000000004493 102.0
TLS3_k127_3503969_6 Belongs to the 'phage' integrase family - - - 0.00000000002643 64.0
TLS3_k127_3503969_7 PFAM Phage derived protein Gp49-like (DUF891) - - - 0.0000004144 53.0
TLS3_k127_3529405_0 belongs to the aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 1.024e-243 766.0
TLS3_k127_3529405_1 saccharopine dehydrogenase activity K00290 - 1.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006733 571.0
TLS3_k127_3529405_10 - - - - 0.0000000000004509 76.0
TLS3_k127_3529405_2 sequence-specific DNA binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 520.0
TLS3_k127_3529405_3 amine dehydrogenase activity K01406 - 3.4.24.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 518.0
TLS3_k127_3529405_4 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 449.0
TLS3_k127_3529405_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 379.0
TLS3_k127_3529405_7 lactoylglutathione lyase activity K08234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002377 256.0
TLS3_k127_3719335_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006153 398.0
TLS3_k127_3719335_1 Mechanosensitive ion channel K03442 - - 0.0000000000000000000000000000000000000000000000000000000004057 210.0
TLS3_k127_3719335_2 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000000000765 198.0
TLS3_k127_3719335_3 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000002089 71.0
TLS3_k127_3766124_0 Glucoamylase and related glycosyl hydrolases - - - 1.111e-257 806.0
TLS3_k127_3766124_1 sodium:proton antiporter activity K03316 - - 7.221e-206 653.0
TLS3_k127_3766124_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 516.0
TLS3_k127_3766124_3 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 499.0
TLS3_k127_3766124_4 Belongs to the pirin family K06911 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 299.0
TLS3_k127_3766124_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000156 222.0
TLS3_k127_3766124_6 PFAM HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000002702 144.0
TLS3_k127_3766124_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.0000000000000000000000003452 111.0
TLS3_k127_3766124_8 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.0000000000003223 70.0
TLS3_k127_37791_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1420.0
TLS3_k127_37791_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 2.472e-198 627.0
TLS3_k127_37791_2 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 367.0
TLS3_k127_37791_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 361.0
TLS3_k127_37791_4 phosphonoacetaldehyde hydrolase activity K20881 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 338.0
TLS3_k127_37791_5 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002477 264.0
TLS3_k127_37791_7 nitric oxide dioxygenase activity K00523 - 1.17.1.1 0.00000000000000000000008567 99.0
TLS3_k127_37791_8 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000002988 70.0
TLS3_k127_37791_9 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000001308 72.0
TLS3_k127_4015155_0 silver ion transport K15726 - - 0.0 1582.0
TLS3_k127_4015155_1 Cation transporter/ATPase, N-terminus - - - 0.0 1246.0
TLS3_k127_4015155_10 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 533.0
TLS3_k127_4015155_11 Glutathione S-transferase K00799,K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7,2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 514.0
TLS3_k127_4015155_12 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 509.0
TLS3_k127_4015155_13 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 504.0
TLS3_k127_4015155_14 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 501.0
TLS3_k127_4015155_15 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 481.0
TLS3_k127_4015155_16 UPF0365 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 474.0
TLS3_k127_4015155_17 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 481.0
TLS3_k127_4015155_18 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 470.0
TLS3_k127_4015155_19 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 441.0
TLS3_k127_4015155_2 Cation transport ATPase (P-type) K01537 - 3.6.3.8 0.0 1135.0
TLS3_k127_4015155_20 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07798,K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 429.0
TLS3_k127_4015155_21 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 428.0
TLS3_k127_4015155_22 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008479 421.0
TLS3_k127_4015155_23 calcium, potassium:sodium antiporter activity K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 392.0
TLS3_k127_4015155_24 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 379.0
TLS3_k127_4015155_25 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 415.0
TLS3_k127_4015155_26 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00627 GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 342.0
TLS3_k127_4015155_28 AMP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 307.0
TLS3_k127_4015155_29 Lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 304.0
TLS3_k127_4015155_3 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1127.0
TLS3_k127_4015155_30 Ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002276 288.0
TLS3_k127_4015155_31 thiolester hydrolase activity K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004574 278.0
TLS3_k127_4015155_32 Amidases related to nicotinamidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003427 277.0
TLS3_k127_4015155_33 AMP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001006 278.0
TLS3_k127_4015155_34 response regulator K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005226 254.0
TLS3_k127_4015155_35 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002232 254.0
TLS3_k127_4015155_36 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002767 258.0
TLS3_k127_4015155_37 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000001217 254.0
TLS3_k127_4015155_38 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281,K12132 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.11.1,3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000007869 230.0
TLS3_k127_4015155_4 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 5.707e-278 872.0
TLS3_k127_4015155_40 Macro domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005796 222.0
TLS3_k127_4015155_41 adenylylsulfate kinase activity K00860,K00955 - 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000006905 220.0
TLS3_k127_4015155_42 IMP dehydrogenase activity K07182 - - 0.000000000000000000000000000000000000000000000000000000006148 202.0
TLS3_k127_4015155_43 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.00000000000000000000000000000000000000000000000000005844 194.0
TLS3_k127_4015155_44 Histidine kinase K07683 - 2.7.13.3 0.0000000000000000000000000000000000000000000000003861 191.0
TLS3_k127_4015155_45 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000007555 168.0
TLS3_k127_4015155_46 AI-2E family transporter - - - 0.000000000000000000000000000000000000000002033 173.0
TLS3_k127_4015155_47 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K12263 - - 0.00000000000000000000000000000000000000003323 156.0
TLS3_k127_4015155_48 translation initiation factor activity K03407,K03646,K04065,K06596,K07277,K12065,K13593 - 2.7.13.3 0.0000000000000000000000000000000000000006241 164.0
TLS3_k127_4015155_49 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.000000000000000000000000000000000000003163 157.0
TLS3_k127_4015155_5 SMART PAS domain containing protein K13924 - 2.1.1.80,3.1.1.61 1.034e-276 889.0
TLS3_k127_4015155_50 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000007812 149.0
TLS3_k127_4015155_51 PFAM Cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000008414 151.0
TLS3_k127_4015155_52 IMP dehydrogenase activity K07182 - - 0.000000000000000000000000000000001003 135.0
TLS3_k127_4015155_53 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000000002527 136.0
TLS3_k127_4015155_55 transferase activity, transferring acyl groups - - - 0.00000000000000000000000000001108 123.0
TLS3_k127_4015155_58 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000000001666 108.0
TLS3_k127_4015155_59 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000007301 112.0
TLS3_k127_4015155_6 MacB-like periplasmic core domain K02004 - - 1.127e-199 630.0
TLS3_k127_4015155_60 protein-glutamate methylesterase K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000001903 101.0
TLS3_k127_4015155_61 Pentapeptide repeat protein - - - 0.000000000000000002423 99.0
TLS3_k127_4015155_62 Belongs to the UPF0337 (CsbD) family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000003668 84.0
TLS3_k127_4015155_63 PFAM SpoVT AbrB - - - 0.0000000000000009228 79.0
TLS3_k127_4015155_64 Cytochrome c K12263 - - 0.000000000000004194 79.0
TLS3_k127_4015155_66 PAS domain - - - 0.0000000000001539 83.0
TLS3_k127_4015155_67 nuclease activity K06218 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000002633 70.0
TLS3_k127_4015155_68 UPF0391 membrane protein - - - 0.000000000004423 69.0
TLS3_k127_4015155_69 - - - - 0.00000000001019 72.0
TLS3_k127_4015155_7 Zinc-binding dehydrogenase K13979 - - 6.795e-197 619.0
TLS3_k127_4015155_70 Virulence factor BrkB K07058 - - 0.000000001231 69.0
TLS3_k127_4015155_71 PIN domain - - - 0.000000001584 62.0
TLS3_k127_4015155_72 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000003237 57.0
TLS3_k127_4015155_73 Protein of unknown function (DUF2459) - - - 0.0000001777 56.0
TLS3_k127_4015155_74 Dodecin K09165 - - 0.0000004986 51.0
TLS3_k127_4015155_75 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000002063 53.0
TLS3_k127_4015155_76 Helix-turn-helix domain - - - 0.000002471 56.0
TLS3_k127_4015155_77 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00001084 52.0
TLS3_k127_4015155_78 Hemerythrin HHE cation binding domain - - - 0.00001694 53.0
TLS3_k127_4015155_79 PFAM CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.0000691 53.0
TLS3_k127_4015155_8 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 582.0
TLS3_k127_4015155_80 mitochondrial gene expression K02935 - - 0.0002171 48.0
TLS3_k127_4015155_81 Restriction endonuclease K07448 - - 0.0002294 44.0
TLS3_k127_4015155_83 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.0009021 50.0
TLS3_k127_4015155_9 Sodium/hydrogen exchanger family K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 543.0
TLS3_k127_4130503_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 553.0
TLS3_k127_4130503_1 bacterial-type flagellum organization K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 360.0
TLS3_k127_4130503_2 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 308.0
TLS3_k127_4130503_3 COGs COG3485 Protocatechuate 3 4-dioxygenase beta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005539 279.0
TLS3_k127_4130503_4 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000004931 215.0
TLS3_k127_4130503_5 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K16079 - - 0.000000000000000000000000000000000000000000000000001453 190.0
TLS3_k127_4130503_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.00000000000000000000000001989 117.0
TLS3_k127_4172575_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 5.092e-196 618.0
TLS3_k127_4172575_1 Flagellar motor switch protein FliM K02416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 466.0
TLS3_k127_4172575_10 flagellar K02418,K02419 - - 0.00000000000000005332 86.0
TLS3_k127_4172575_2 Plays a role in the flagellum-specific transport system K02419 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009349 347.0
TLS3_k127_4172575_3 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 345.0
TLS3_k127_4172575_4 Flagellar basal body protein FlaE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 307.0
TLS3_k127_4172575_5 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.000000000000000000000000000000000000000002175 161.0
TLS3_k127_4172575_6 Type III flagellar switch regulator (C-ring) FliN C-term K02417 - - 0.00000000000000000000000000000000000002478 147.0
TLS3_k127_4172575_7 Role in flagellar biosynthesis K02421 - - 0.0000000000000000000000000000000006491 140.0
TLS3_k127_4172575_8 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000000000000000000000000000000001243 138.0
TLS3_k127_4172575_9 Role in flagellar biosynthesis K02420 - - 0.000000000000000000000000000002998 121.0
TLS3_k127_422525_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1101.0
TLS3_k127_422525_1 xylulokinase activity K00854 - 2.7.1.17 0.0 1012.0
TLS3_k127_422525_10 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000559 523.0
TLS3_k127_422525_11 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 510.0
TLS3_k127_422525_12 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 497.0
TLS3_k127_422525_13 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007271 488.0
TLS3_k127_422525_14 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 435.0
TLS3_k127_422525_15 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 402.0
TLS3_k127_422525_16 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 397.0
TLS3_k127_422525_17 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009911 390.0
TLS3_k127_422525_18 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008483 374.0
TLS3_k127_422525_19 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 361.0
TLS3_k127_422525_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 1.047e-243 758.0
TLS3_k127_422525_21 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 352.0
TLS3_k127_422525_22 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003628 359.0
TLS3_k127_422525_23 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 339.0
TLS3_k127_422525_24 precorrin-2 dehydrogenase activity K02302,K02304 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 311.0
TLS3_k127_422525_25 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 286.0
TLS3_k127_422525_26 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 284.0
TLS3_k127_422525_27 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006114 284.0
TLS3_k127_422525_28 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002137 261.0
TLS3_k127_422525_29 PFAM AIG2 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001578 246.0
TLS3_k127_422525_3 PhoQ Sensor - - - 1.25e-241 778.0
TLS3_k127_422525_30 signal-transduction protein containing cAMP-binding and CBS domains K02342,K05847,K07182 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000005303 215.0
TLS3_k127_422525_31 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000000001028 213.0
TLS3_k127_422525_32 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000009139 203.0
TLS3_k127_422525_33 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000000000002661 205.0
TLS3_k127_422525_34 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000547 185.0
TLS3_k127_422525_35 Thiamine-binding protein - - - 0.000000000000000000000000000000000000000000000347 168.0
TLS3_k127_422525_36 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000000000000000005403 158.0
TLS3_k127_422525_37 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000003351 166.0
TLS3_k127_422525_38 - - - - 0.000000000000000000000000000000000000003459 151.0
TLS3_k127_422525_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 1.75e-204 645.0
TLS3_k127_422525_40 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.000000000000000000000000000000006647 131.0
TLS3_k127_422525_41 Sulfurtransferase TusA - - - 0.000000000000000000000000007244 111.0
TLS3_k127_422525_5 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 1.304e-195 623.0
TLS3_k127_422525_6 Competence protein K02238 - - 3.015e-195 637.0
TLS3_k127_422525_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 565.0
TLS3_k127_422525_8 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 561.0
TLS3_k127_422525_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 556.0
TLS3_k127_4225712_0 radical SAM domain protein - - - 5e-324 1004.0
TLS3_k127_4225712_1 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 3.338e-303 949.0
TLS3_k127_4225712_10 2Fe-2S iron-sulfur cluster binding domain K00240,K00245 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 340.0
TLS3_k127_4225712_11 Glycosyl transferases group 1 K12995 - 2.4.1.348 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 340.0
TLS3_k127_4225712_12 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 343.0
TLS3_k127_4225712_13 Asparaginase K13051 - 3.4.19.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 337.0
TLS3_k127_4225712_14 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 337.0
TLS3_k127_4225712_15 SurA N-terminal domain K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 335.0
TLS3_k127_4225712_16 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 323.0
TLS3_k127_4225712_17 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 324.0
TLS3_k127_4225712_18 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 308.0
TLS3_k127_4225712_19 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 325.0
TLS3_k127_4225712_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 3.628e-239 751.0
TLS3_k127_4225712_20 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004521 302.0
TLS3_k127_4225712_22 Evidence 2b Function of strongly homologous gene K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008842 273.0
TLS3_k127_4225712_23 WavE lipopolysaccharide synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000147 273.0
TLS3_k127_4225712_25 PFAM ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000001937 246.0
TLS3_k127_4225712_26 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000000000002385 233.0
TLS3_k127_4225712_27 WYL domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001604 235.0
TLS3_k127_4225712_28 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000001601 229.0
TLS3_k127_4225712_29 pterin-4-alpha-carbinolamine dehydratase K01724 GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 0.00000000000000000000000000000000000000000000000000000000000001672 216.0
TLS3_k127_4225712_3 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 511.0
TLS3_k127_4225712_30 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - - 0.0000000000000000000000000000000000000000000000000000000000005439 233.0
TLS3_k127_4225712_31 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06991 - - 0.0000000000000000000000000000000000000000000000000000000002391 205.0
TLS3_k127_4225712_32 peroxiredoxin activity K00627,K01607 - 2.3.1.12,4.1.1.44 0.000000000000000000000000000000000000000000000000000000001994 203.0
TLS3_k127_4225712_33 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000001726 197.0
TLS3_k127_4225712_34 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.0000000000000000000000000000000000000000000000000001972 192.0
TLS3_k127_4225712_35 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000001097 180.0
TLS3_k127_4225712_36 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000002504 181.0
TLS3_k127_4225712_37 D,D-heptose 1,7-bisphosphate phosphatase - - - 0.0000000000000000000000000000000000000000545 166.0
TLS3_k127_4225712_4 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 454.0
TLS3_k127_4225712_40 glutamine-fructose-6-phosphate transaminase (isomerizing) activity - - - 0.000000000000000000000000000000000000103 146.0
TLS3_k127_4225712_41 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798,K13525 - - 0.00000000000000000000000000000000001569 154.0
TLS3_k127_4225712_42 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000001586 142.0
TLS3_k127_4225712_44 Pfam:TPM K08988 - - 0.0000000000000000000000000003015 125.0
TLS3_k127_4225712_46 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000002299 96.0
TLS3_k127_4225712_47 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000368 100.0
TLS3_k127_4225712_48 PIN domain K07064 - - 0.00000000008036 68.0
TLS3_k127_4225712_49 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00001098 48.0
TLS3_k127_4225712_5 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 455.0
TLS3_k127_4225712_50 ORF6N domain - - - 0.00002354 48.0
TLS3_k127_4225712_51 4-alpha-glucanotransferase K00705 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.25 0.0001491 49.0
TLS3_k127_4225712_6 DNA-binding transcription factor activity K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 450.0
TLS3_k127_4225712_7 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 426.0
TLS3_k127_4225712_8 transmembrane transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 384.0
TLS3_k127_4225712_9 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007656 345.0
TLS3_k127_4354383_0 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 357.0
TLS3_k127_4354383_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 288.0
TLS3_k127_4354383_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000001996 261.0
TLS3_k127_4394396_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000002684 214.0
TLS3_k127_4394396_10 - - - - 0.000000001 63.0
TLS3_k127_4394396_11 nucleotidyltransferase activity K07075 - - 0.000000003931 61.0
TLS3_k127_4394396_12 - - - - 0.000003436 55.0
TLS3_k127_4394396_13 Plasmid maintenance system antidote protein K21498 - - 0.0001616 46.0
TLS3_k127_4394396_2 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.000000000000000000000000000000000000000000000000002006 183.0
TLS3_k127_4394396_3 Plasmid maintenance system killer K07334 - - 0.00000000000000000000000000000005466 126.0
TLS3_k127_4394396_4 Protein of unknown function (DUF1778) - - - 0.000000000000000000000006759 104.0
TLS3_k127_4394396_5 - - - - 0.0000000000000000000001456 104.0
TLS3_k127_4394396_6 Type II secretion system (T2SS), protein M K02462 - - 0.00000000000000004579 88.0
TLS3_k127_4394396_7 SpoVT / AbrB like domain K07172 - - 0.000000000000005631 78.0
TLS3_k127_4394396_9 - - - - 0.00000000006677 70.0
TLS3_k127_4444063_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 3.671e-303 941.0
TLS3_k127_4444063_1 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 2.526e-241 756.0
TLS3_k127_4444063_10 Belongs to the sulfur carrier protein TusA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002967 231.0
TLS3_k127_4444063_11 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000008941 210.0
TLS3_k127_4444063_12 - - - - 0.000000000000000000000000000000000000000000000000000001096 195.0
TLS3_k127_4444063_14 Sulfurtransferase TusA - - - 0.00000000000000000000000000000000000000004178 153.0
TLS3_k127_4444063_15 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000003364 111.0
TLS3_k127_4444063_16 - - - - 0.0000000000000001782 81.0
TLS3_k127_4444063_17 - - - - 0.000000003675 61.0
TLS3_k127_4444063_2 Male sterility protein K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 545.0
TLS3_k127_4444063_3 GTP-binding GTPase Middle Region K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 490.0
TLS3_k127_4444063_4 Rieske (2fe-2S) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 476.0
TLS3_k127_4444063_5 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 471.0
TLS3_k127_4444063_6 Formiminotransferase domain K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 441.0
TLS3_k127_4444063_7 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 346.0
TLS3_k127_4444063_8 uroporphyrinogen-III synthase activity K01719,K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 339.0
TLS3_k127_4444063_9 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 308.0
TLS3_k127_4449707_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 6.295e-241 756.0
TLS3_k127_4449707_1 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 419.0
TLS3_k127_4449707_2 PFAM Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 376.0
TLS3_k127_4449707_3 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000577 358.0
TLS3_k127_4449707_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007743 336.0
TLS3_k127_4449707_6 - - - - 0.000000000000004912 80.0
TLS3_k127_4449707_7 endoribonuclease activity K03628,K15125 GO:0005575,GO:0005576 - 0.000000000349 65.0
TLS3_k127_4459298_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 5e-324 1004.0
TLS3_k127_4459298_1 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 3.537e-295 934.0
TLS3_k127_4459298_10 SIS domain K03271 - 5.3.1.28 4.432e-208 665.0
TLS3_k127_4459298_11 PFAM Alcohol dehydrogenase - - - 1.961e-204 641.0
TLS3_k127_4459298_12 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000628 609.0
TLS3_k127_4459298_13 Ammonium transporter K03320,K06580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000631 596.0
TLS3_k127_4459298_14 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700,K01236 - 2.4.1.18,3.2.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 599.0
TLS3_k127_4459298_15 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 451.0
TLS3_k127_4459298_16 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 444.0
TLS3_k127_4459298_17 PFAM Short-chain dehydrogenase reductase SDR K00034 - 1.1.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 419.0
TLS3_k127_4459298_18 PFAM glycosyl transferase family 9 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 422.0
TLS3_k127_4459298_19 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008958 419.0
TLS3_k127_4459298_2 nodulation K00612 - - 5.144e-265 827.0
TLS3_k127_4459298_20 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 411.0
TLS3_k127_4459298_21 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 412.0
TLS3_k127_4459298_22 Carboxylesterase family K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 375.0
TLS3_k127_4459298_23 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 372.0
TLS3_k127_4459298_24 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 357.0
TLS3_k127_4459298_25 photoreceptor activity K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 365.0
TLS3_k127_4459298_26 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 342.0
TLS3_k127_4459298_27 Glycosyltransferase like family 2 K00786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 328.0
TLS3_k127_4459298_28 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 327.0
TLS3_k127_4459298_29 PFAM glycosyl transferase family 9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 328.0
TLS3_k127_4459298_3 thiamine pyrophosphate protein TPP binding domain protein K00156,K00158 - 1.2.3.3,1.2.5.1 1.824e-261 817.0
TLS3_k127_4459298_30 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007377 321.0
TLS3_k127_4459298_31 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 310.0
TLS3_k127_4459298_32 Membrane K08984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 297.0
TLS3_k127_4459298_33 'ABC-type proline glycine betaine transport K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 292.0
TLS3_k127_4459298_34 glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000153 291.0
TLS3_k127_4459298_35 ABC-type glycine betaine transport system K05845 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004127 276.0
TLS3_k127_4459298_36 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002327 263.0
TLS3_k127_4459298_37 Membrane K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002068 256.0
TLS3_k127_4459298_38 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001092 253.0
TLS3_k127_4459298_39 Pfam:KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003004 257.0
TLS3_k127_4459298_4 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 6.374e-258 812.0
TLS3_k127_4459298_40 AMP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000003678 242.0
TLS3_k127_4459298_41 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006431 231.0
TLS3_k127_4459298_42 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000009536 229.0
TLS3_k127_4459298_43 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000002964 227.0
TLS3_k127_4459298_44 Restriction endonuclease XhoI - - - 0.0000000000000000000000000000000000000000000000000000000000000003833 228.0
TLS3_k127_4459298_45 Ferritin, Dps family protein K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000007366 224.0
TLS3_k127_4459298_46 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000002205 219.0
TLS3_k127_4459298_47 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000000000000000000000000001454 227.0
TLS3_k127_4459298_48 Polynucleotide kinase 3 phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000001715 224.0
TLS3_k127_4459298_49 Cyclase dehydrase - - - 0.0000000000000000000000000000000000000000000000000000000009546 211.0
TLS3_k127_4459298_5 Eco57I restriction-modification methylase - - - 1.362e-257 805.0
TLS3_k127_4459298_50 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000000000007981 206.0
TLS3_k127_4459298_51 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000002206 222.0
TLS3_k127_4459298_52 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000005359 216.0
TLS3_k127_4459298_53 PFAM binding-protein-dependent transport systems inner membrane component K05846 - - 0.00000000000000000000000000000000000000000000000000001881 194.0
TLS3_k127_4459298_54 PFAM response regulator receiveR - - - 0.00000000000000000000000000000000000000000000000000003367 191.0
TLS3_k127_4459298_55 - - - - 0.00000000000000000000000000000000000000000000000000004296 195.0
TLS3_k127_4459298_56 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000148 184.0
TLS3_k127_4459298_57 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000000000002079 181.0
TLS3_k127_4459298_58 response regulator K02282 - - 0.000000000000000000000000000000000000000000000717 173.0
TLS3_k127_4459298_59 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000007191 168.0
TLS3_k127_4459298_6 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.773e-246 774.0
TLS3_k127_4459298_60 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons - - - 0.000000000000000000000000000000000000000004167 161.0
TLS3_k127_4459298_61 TIGRFAM carbohydrate kinase, thermoresistant glucokinase family K00851 - 2.7.1.12 0.0000000000000000000000000000000000000001321 157.0
TLS3_k127_4459298_62 Domain of unknown function (DUF4383) - - - 0.0000000000000000000000000000000000000001629 154.0
TLS3_k127_4459298_63 regulation of translation K03704,K05809 - - 0.00000000000000000000000000000000000005544 149.0
TLS3_k127_4459298_64 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000000000000005748 159.0
TLS3_k127_4459298_65 Protein of unknown function (DUF3015) - - - 0.000000000000000000000000000000278 128.0
TLS3_k127_4459298_66 - - - - 0.0000000000000000000000000001443 120.0
TLS3_k127_4459298_67 Hemerythrin - - - 0.00000000000000000000000006664 116.0
TLS3_k127_4459298_68 - - - - 0.000000000000000000000000573 108.0
TLS3_k127_4459298_69 response regulator K02479 - - 0.00000000000000000000002135 116.0
TLS3_k127_4459298_7 TIGRFAM malto-oligosyltrehalose trehalohydrolase K01236 - 3.2.1.141 2.996e-227 720.0
TLS3_k127_4459298_70 - - - - 0.0000000000000000000007841 101.0
TLS3_k127_4459298_71 PhoQ Sensor - - - 0.000000000000000000015 106.0
TLS3_k127_4459298_72 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000000002284 98.0
TLS3_k127_4459298_73 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000002769 90.0
TLS3_k127_4459298_74 Histidine kinase - - - 0.000000000000002337 76.0
TLS3_k127_4459298_75 Hemerythrin - - - 0.00000000000002934 81.0
TLS3_k127_4459298_76 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K10936,K16079 - - 0.0000000000001524 82.0
TLS3_k127_4459298_77 Bacterial signalling protein N terminal repeat - - - 0.0000000000009076 80.0
TLS3_k127_4459298_78 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000001307 72.0
TLS3_k127_4459298_79 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0000000001288 66.0
TLS3_k127_4459298_8 Glycogen debranching enzyme N terminal - - - 6.573e-216 691.0
TLS3_k127_4459298_80 Heme oxygenase K07215 - 1.14.99.58 0.0000000003334 70.0
TLS3_k127_4459298_81 PQ loop repeat K15383 - - 0.0000001262 57.0
TLS3_k127_4459298_82 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000004339 63.0
TLS3_k127_4459298_84 CBS domain pair - - - 0.0001518 52.0
TLS3_k127_4459298_85 PQ loop repeat K15383 - - 0.0006693 43.0
TLS3_k127_4459298_9 PFAM SNARE associated Golgi protein - - - 6.018e-213 683.0
TLS3_k127_4493537_0 helicase activity K03579 - 3.6.4.13 8.282e-311 973.0
TLS3_k127_4493537_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.233e-226 713.0
TLS3_k127_4493537_10 Protein of unknown function (DUF1232) - - - 0.00000000000000000003176 94.0
TLS3_k127_4493537_12 - - - - 0.00000000000000001407 83.0
TLS3_k127_4493537_13 Membrane - - - 0.0000000000000008167 81.0
TLS3_k127_4493537_15 Domain of unknown function (DUF202) K00389 - - 0.000000006119 60.0
TLS3_k127_4493537_16 COG3209 Rhs family protein - - - 0.00005867 54.0
TLS3_k127_4493537_17 - - - - 0.0007619 44.0
TLS3_k127_4493537_2 glucose-6-phosphate dehydrogenase activity K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004565 529.0
TLS3_k127_4493537_3 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 522.0
TLS3_k127_4493537_4 Integral membrane protein TerC family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 344.0
TLS3_k127_4493537_5 Ribulose bisphosphate carboxylase large chain, catalytic domain K01601,K08965 - 4.1.1.39,5.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000001826 255.0
TLS3_k127_4493537_6 SMP-30/Gluconolaconase/LRE-like region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004385 250.0
TLS3_k127_4493537_7 hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000008324 206.0
TLS3_k127_4493537_8 lactoylglutathione lyase activity K08234 - - 0.00000000000000000000000005219 107.0
TLS3_k127_4504961_0 alpha-ribazole phosphatase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.0 1086.0
TLS3_k127_4504961_1 cobalamin-transporting ATPase activity K02014,K16092 - - 5.015e-226 721.0
TLS3_k127_4504961_10 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 444.0
TLS3_k127_4504961_11 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 389.0
TLS3_k127_4504961_12 Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 387.0
TLS3_k127_4504961_13 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 377.0
TLS3_k127_4504961_14 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 376.0
TLS3_k127_4504961_15 Major facilitator K03762 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005891 359.0
TLS3_k127_4504961_16 coenzyme F420-1:gamma-L-glutamate ligase activity K00768,K04719 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016491,GO:0016705,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,2.4.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009312 341.0
TLS3_k127_4504961_17 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 346.0
TLS3_k127_4504961_18 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 338.0
TLS3_k127_4504961_19 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 321.0
TLS3_k127_4504961_2 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K02660 - - 9.466e-201 643.0
TLS3_k127_4504961_20 cob(I)yrinic acid a,c-diamide adenosyltransferase activity K00798,K13821 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007896 311.0
TLS3_k127_4504961_21 PFAM Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008213 325.0
TLS3_k127_4504961_22 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 310.0
TLS3_k127_4504961_23 nuclear chromosome segregation K02666,K03497,K19622 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003623 276.0
TLS3_k127_4504961_24 Adenosylcobinamide amidohydrolase K02013,K02231 - 2.7.1.156,2.7.7.62,3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000005729 258.0
TLS3_k127_4504961_25 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000002935 239.0
TLS3_k127_4504961_26 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000006049 241.0
TLS3_k127_4504961_27 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000000000000000001434 214.0
TLS3_k127_4504961_28 cheY-homologous receiver domain K02658 - - 0.00000000000000000000000000000000000000000000000000000000009313 207.0
TLS3_k127_4504961_29 Cobinamide kinase / cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000000000000000945 192.0
TLS3_k127_4504961_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 5.947e-197 623.0
TLS3_k127_4504961_30 PFAM metal-dependent phosphohydrolase, HD sub domain K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000004118 193.0
TLS3_k127_4504961_31 - - - - 0.000000000000000000000000000000000000000000000000009947 189.0
TLS3_k127_4504961_33 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078,K05553 - - 0.0000000000000000000000000002494 120.0
TLS3_k127_4504961_34 Uncharacterized protein conserved in bacteria (DUF2314) - - - 0.000000000000000000000000003313 117.0
TLS3_k127_4504961_35 chemotaxis K02659,K03408,K03415,K11524 - - 0.000000000000000000000000007305 115.0
TLS3_k127_4504961_36 chemotaxis K03408,K03415 - - 0.0000000000000000000000001953 112.0
TLS3_k127_4504961_37 Parallel beta-helix repeats - - - 0.0000000000000000000000004717 120.0
TLS3_k127_4504961_39 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000002645 100.0
TLS3_k127_4504961_4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009527 591.0
TLS3_k127_4504961_40 photosystem II stabilization K00703,K02237,K02238 - 2.4.1.21 0.000000000001279 74.0
TLS3_k127_4504961_42 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00382 - 1.8.1.4 0.0000000006684 64.0
TLS3_k127_4504961_44 - - - - 0.000000008964 59.0
TLS3_k127_4504961_45 DNA integration - - - 0.00000002359 59.0
TLS3_k127_4504961_46 Transposase - - - 0.0000005258 52.0
TLS3_k127_4504961_48 Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3' - - - 0.0002316 45.0
TLS3_k127_4504961_49 - - - - 0.0002496 43.0
TLS3_k127_4504961_5 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 591.0
TLS3_k127_4504961_6 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 526.0
TLS3_k127_4504961_7 Signal transducing histidine kinase, homodimeric domain K02487,K03407,K06596 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 480.0
TLS3_k127_4504961_8 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008983 451.0
TLS3_k127_4504961_9 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 446.0
TLS3_k127_4562358_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798,K04076,K13525,K17681 - 3.4.21.53 2.504e-235 734.0
TLS3_k127_4562358_1 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009788 465.0
TLS3_k127_4562358_2 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 398.0
TLS3_k127_4562358_3 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000008222 102.0
TLS3_k127_4584764_0 lipopolysaccharide transport K22110 - - 0.0 1528.0
TLS3_k127_4584764_1 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0 1048.0
TLS3_k127_4584764_10 tRNA thio-modification K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 541.0
TLS3_k127_4584764_11 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 536.0
TLS3_k127_4584764_12 Evidence 2b Function of strongly homologous gene K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 522.0
TLS3_k127_4584764_13 imidazolonepropionase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 508.0
TLS3_k127_4584764_14 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008685 473.0
TLS3_k127_4584764_15 converts alpha-aldose to the beta-anomer K01785 GO:0003674,GO:0003824,GO:0004034,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006082,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1902776,GO:1902777 5.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 454.0
TLS3_k127_4584764_16 pectinesterase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 415.0
TLS3_k127_4584764_17 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K07052 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008999 402.0
TLS3_k127_4584764_18 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 376.0
TLS3_k127_4584764_19 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 371.0
TLS3_k127_4584764_2 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 9.2e-322 1014.0
TLS3_k127_4584764_20 Protein of unknown function (DUF3047) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 350.0
TLS3_k127_4584764_21 methyltransferase activity K00569 - 2.1.1.67 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 304.0
TLS3_k127_4584764_22 Pfam SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 308.0
TLS3_k127_4584764_23 heat shock protein binding K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 294.0
TLS3_k127_4584764_24 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 289.0
TLS3_k127_4584764_25 Histidine kinase K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 283.0
TLS3_k127_4584764_26 ADP-glyceromanno-heptose 6-epimerase activity K00311 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000771 275.0
TLS3_k127_4584764_27 Putative oxalocrotonate tautomerase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002137 261.0
TLS3_k127_4584764_28 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000006279 265.0
TLS3_k127_4584764_29 silver ion transport K15726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002735 260.0
TLS3_k127_4584764_3 COG0659 Sulfate permease and related transporters (MFS K01673,K03321 - 4.2.1.1 1.603e-306 956.0
TLS3_k127_4584764_30 Carbonic anhydrase K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000005017 241.0
TLS3_k127_4584764_31 - K11477 - - 0.000000000000000000000000000000000000000000000000000000000000000001206 231.0
TLS3_k127_4584764_32 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000005522 224.0
TLS3_k127_4584764_33 silver ion transport K15726 - - 0.000000000000000000000000000000000000000000000000000001012 197.0
TLS3_k127_4584764_34 protein conserved in bacteria K05805 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000002976 199.0
TLS3_k127_4584764_35 endonuclease activity K03465 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.1.1.148 0.0000000000000000000000000000000000000000000000001814 178.0
TLS3_k127_4584764_36 - - - - 0.000000000000000000000000000000000000000000000001929 186.0
TLS3_k127_4584764_37 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000001119 178.0
TLS3_k127_4584764_38 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000006744 160.0
TLS3_k127_4584764_39 RelA SpoT - - - 0.000000000000000000000000000000000000000007392 167.0
TLS3_k127_4584764_4 Glycogen debranching enzyme - - - 2.383e-274 859.0
TLS3_k127_4584764_41 protein secretion - - - 0.000000000000000000000000000000549 142.0
TLS3_k127_4584764_42 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000000000000006947 125.0
TLS3_k127_4584764_43 Sel1-like repeats. - - - 0.00000000000000000000000000006049 122.0
TLS3_k127_4584764_44 silver ion transport K15726 - - 0.0000000000000000000000000005418 118.0
TLS3_k127_4584764_45 - - - - 0.000000000000000000000000003709 111.0
TLS3_k127_4584764_46 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000961 114.0
TLS3_k127_4584764_47 PFAM Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000001385 103.0
TLS3_k127_4584764_49 conserved protein UCP025560 K09978 - - 0.00000000000000000002172 94.0
TLS3_k127_4584764_5 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00382 - 1.8.1.4 4.232e-267 830.0
TLS3_k127_4584764_51 metallopeptidase activity K07404 - 3.1.1.31 0.000000000000000000179 102.0
TLS3_k127_4584764_52 Protein of unknown function (DUF1269) - - - 0.000000000000000001485 91.0
TLS3_k127_4584764_53 Lipoprotein - - - 0.000000000000000002196 86.0
TLS3_k127_4584764_54 Lactonase, 7-bladed beta-propeller - - - 0.00000000000008249 83.0
TLS3_k127_4584764_55 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000003259 71.0
TLS3_k127_4584764_56 Universal stress protein - - - 0.000000000001127 77.0
TLS3_k127_4584764_57 membrane - - - 0.000000000005107 66.0
TLS3_k127_4584764_58 silver ion transport K15726 - - 0.00000000001009 71.0
TLS3_k127_4584764_6 Trypsin-like peptidase domain - - - 3.009e-209 674.0
TLS3_k127_4584764_60 Domain of unknown function DUF21 K03699 - - 0.0000000002477 63.0
TLS3_k127_4584764_61 signal-transduction protein containing cAMP-binding and CBS domains K06041 - 5.3.1.13 0.000000002441 58.0
TLS3_k127_4584764_62 - - - - 0.00000001134 64.0
TLS3_k127_4584764_7 Sugar (and other) transporter K08178 - - 3.538e-206 649.0
TLS3_k127_4584764_8 drug transmembrane transporter activity K03327 - - 5.483e-204 642.0
TLS3_k127_4584764_9 - K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009309 584.0
TLS3_k127_4687605_0 Formate--tetrahydrofolate ligase K01938 GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 1.844e-270 841.0
TLS3_k127_4687605_1 succinyl-diaminopimelate desuccinylase activity - - - 5.381e-235 733.0
TLS3_k127_4687605_3 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 528.0
TLS3_k127_4687605_4 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 437.0
TLS3_k127_4687605_5 response regulator K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 287.0
TLS3_k127_4687605_6 stress-induced mitochondrial fusion K04087 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000427 227.0
TLS3_k127_4687605_8 - - - - 0.00000000000000000000000000000000000001646 155.0
TLS3_k127_4687605_9 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000197 106.0
TLS3_k127_4835333_0 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 497.0
TLS3_k127_4835333_1 response regulator K02479,K07695 GO:0001666,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009405,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0018995,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030312,GO:0030430,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032502,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0036293,GO:0043656,GO:0043657,GO:0044174,GO:0044215,GO:0044216,GO:0044217,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070482,GO:0071944,GO:0072493,GO:0080090,GO:0080134,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1902882,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.0000000000000000000000000000008112 131.0
TLS3_k127_484155_0 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 286.0
TLS3_k127_484155_1 Cupin 2, conserved barrel domain protein - - - 0.0000005268 55.0
TLS3_k127_4848926_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 1.122e-246 769.0
TLS3_k127_4848926_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 1.68e-238 754.0
TLS3_k127_4848926_10 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 398.0
TLS3_k127_4848926_11 Protein conserved in bacteria K06320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006933 394.0
TLS3_k127_4848926_12 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 383.0
TLS3_k127_4848926_13 Fructose-1-6-bisphosphatase, N-terminal domain K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 374.0
TLS3_k127_4848926_14 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 361.0
TLS3_k127_4848926_15 Glycosyl transferase family 2 K12984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 358.0
TLS3_k127_4848926_16 PFAM glycosyl transferase family 9 K02849 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 345.0
TLS3_k127_4848926_17 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 313.0
TLS3_k127_4848926_18 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 309.0
TLS3_k127_4848926_19 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 - 2.7.7.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 305.0
TLS3_k127_4848926_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 2.759e-222 696.0
TLS3_k127_4848926_20 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000674 304.0
TLS3_k127_4848926_21 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002527 283.0
TLS3_k127_4848926_22 PFAM Glycosyl transferase family 4 K13007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004223 279.0
TLS3_k127_4848926_23 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004511 265.0
TLS3_k127_4848926_24 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000000000000000000000002527 239.0
TLS3_k127_4848926_25 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000003311 238.0
TLS3_k127_4848926_26 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000004004 237.0
TLS3_k127_4848926_27 Pfam Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000001373 216.0
TLS3_k127_4848926_28 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.00000000000000000000000000000000000000000000000001733 187.0
TLS3_k127_4848926_29 Glycosyl transferase family 2 K12984 - - 0.00000000000000000000000000000000000000000000001045 188.0
TLS3_k127_4848926_3 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 1.686e-220 693.0
TLS3_k127_4848926_30 protein-(glutamine-N5) methyltransferase activity - - - 0.0000000000000000000000000000000000000000002439 164.0
TLS3_k127_4848926_31 YacP-like NYN domain K06962 - - 0.00000000000000000000000006087 113.0
TLS3_k127_4848926_32 phosphate starvation-inducible protein, PsiF - - - 0.000000000000000000000006865 105.0
TLS3_k127_4848926_33 methyltransferase - - - 0.000000000000000000002415 105.0
TLS3_k127_4848926_34 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K13010 - 2.6.1.102 0.0000004722 51.0
TLS3_k127_4848926_4 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 543.0
TLS3_k127_4848926_5 Male sterility protein K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 526.0
TLS3_k127_4848926_6 Male sterility protein K08678 - 4.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 518.0
TLS3_k127_4848926_7 Polysaccharide biosynthesis protein CapD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 522.0
TLS3_k127_4848926_8 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 419.0
TLS3_k127_4848926_9 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 418.0
TLS3_k127_485701_0 Prokaryotic N-terminal methylation motif - - - 0.00000000000000004603 93.0
TLS3_k127_485701_1 Xylose isomerase-like TIM barrel - - - 0.0000000000000003562 80.0
TLS3_k127_4913181_0 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0 1081.0
TLS3_k127_4913181_1 Bacterial regulatory protein, Fis family K02481,K07713,K07714 - - 1.207e-244 763.0
TLS3_k127_4913181_10 response regulator K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 423.0
TLS3_k127_4913181_11 PFAM beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 421.0
TLS3_k127_4913181_12 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 366.0
TLS3_k127_4913181_14 N-6 DNA methylase K03427 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 319.0
TLS3_k127_4913181_15 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000001394 262.0
TLS3_k127_4913181_16 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005403 246.0
TLS3_k127_4913181_17 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000346 243.0
TLS3_k127_4913181_18 AhpC/TSA family K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000005379 237.0
TLS3_k127_4913181_19 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.00000000000000000000000000000000000000000000000000000000000000000006335 236.0
TLS3_k127_4913181_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 2.592e-205 645.0
TLS3_k127_4913181_20 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000000000000000000000000000006 217.0
TLS3_k127_4913181_21 Rhodanese-like domain - - - 0.000000000000000000000000000000000000000000000000000005906 191.0
TLS3_k127_4913181_22 Cyclophilin-like K09143 - - 0.0000000000000000000000000000000000000000000000000005829 190.0
TLS3_k127_4913181_24 protein serine/threonine phosphatase activity K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000007414 191.0
TLS3_k127_4913181_25 N-6 DNA methylase K03427 - 2.1.1.72 0.000000000000000000000000000000000000005989 147.0
TLS3_k127_4913181_26 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000001292 128.0
TLS3_k127_4913181_27 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000007488 132.0
TLS3_k127_4913181_28 Mo-molybdopterin cofactor metabolic process K03636 - - 0.000000000000000000000000000007828 128.0
TLS3_k127_4913181_29 Protein of unknown function (DUF507) - - - 0.000000000000000000000000000008252 120.0
TLS3_k127_4913181_3 phosphorelay sensor kinase activity K02038,K02282,K07018,K07315 - 3.1.3.3 1.352e-200 676.0
TLS3_k127_4913181_30 RNase_H superfamily K07502 - - 0.00000000000000000000000000002186 123.0
TLS3_k127_4913181_31 Protein of unknown function (DUF507) - - - 0.00000000000000000000000009201 109.0
TLS3_k127_4913181_32 YtxH-like protein - - - 0.00004851 50.0
TLS3_k127_4913181_33 - - - - 0.00006391 50.0
TLS3_k127_4913181_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 496.0
TLS3_k127_4913181_5 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 508.0
TLS3_k127_4913181_6 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 488.0
TLS3_k127_4913181_8 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 477.0
TLS3_k127_4913181_9 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 457.0
TLS3_k127_4937213_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.107e-309 962.0
TLS3_k127_4937213_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 1.239e-262 822.0
TLS3_k127_4937213_2 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 528.0
TLS3_k127_4937213_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 285.0
TLS3_k127_4937213_5 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000002092 243.0
TLS3_k127_4973311_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1510.0
TLS3_k127_4973311_1 Rubrerythrin K22405 - 1.6.3.4 0.0 1199.0
TLS3_k127_4973311_10 phosphate transport system permease protein K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 563.0
TLS3_k127_4973311_11 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005159 550.0
TLS3_k127_4973311_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 503.0
TLS3_k127_4973311_13 Proto-chlorophyllide reductase 57 kD subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 466.0
TLS3_k127_4973311_14 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 448.0
TLS3_k127_4973311_15 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005785 445.0
TLS3_k127_4973311_16 phosphate ion binding K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 443.0
TLS3_k127_4973311_17 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008456 432.0
TLS3_k127_4973311_18 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 430.0
TLS3_k127_4973311_19 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 411.0
TLS3_k127_4973311_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0 997.0
TLS3_k127_4973311_20 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 391.0
TLS3_k127_4973311_21 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 384.0
TLS3_k127_4973311_22 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007411 380.0
TLS3_k127_4973311_23 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 372.0
TLS3_k127_4973311_24 Phosphate-selective porin O and P - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 377.0
TLS3_k127_4973311_25 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 368.0
TLS3_k127_4973311_26 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 308.0
TLS3_k127_4973311_27 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 305.0
TLS3_k127_4973311_28 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 299.0
TLS3_k127_4973311_29 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 297.0
TLS3_k127_4973311_3 Elongator protein 3, MiaB family, Radical SAM - - - 1.929e-306 947.0
TLS3_k127_4973311_30 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004728 274.0
TLS3_k127_4973311_33 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000000000000000000000001285 213.0
TLS3_k127_4973311_34 lipoyl(octanoyl) transferase activity K03644,K03801 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181,2.8.1.8 0.0000000000000000000000000000000000000000000000000000000002937 210.0
TLS3_k127_4973311_35 Protein conserved in bacteria K09922 - - 0.00000000000000000000000000000000000000000000000002905 181.0
TLS3_k127_4973311_37 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000001219 186.0
TLS3_k127_4973311_38 bacterial (prokaryotic) histone like domain K05788 - - 0.000000000000000000000000000000000000000000000008036 172.0
TLS3_k127_4973311_4 Iron-sulfur cluster-binding domain - - - 8.39e-275 848.0
TLS3_k127_4973311_43 DDE superfamily endonuclease - - - 0.0000000000000000002675 88.0
TLS3_k127_4973311_46 Peptide methionine sulfoxide reductase K07304,K12267 - 1.8.4.11,1.8.4.12 0.00000000001306 68.0
TLS3_k127_4973311_49 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000006125 60.0
TLS3_k127_4973311_5 glutamate dehydrogenase [NAD(P)+] activity K00261,K00262 - 1.4.1.3,1.4.1.4 3.06e-223 697.0
TLS3_k127_4973311_51 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0001199 44.0
TLS3_k127_4973311_52 Molecular chaperone. Has ATPase activity K04079 - - 0.0002776 49.0
TLS3_k127_4973311_6 Binding-protein-dependent transport system inner membrane component K02037,K02038 - - 3.403e-207 668.0
TLS3_k127_4973311_7 NeuB family K03856 - 2.5.1.54 1.478e-201 630.0
TLS3_k127_4973311_8 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004821 608.0
TLS3_k127_4973311_9 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 584.0
TLS3_k127_4977876_0 Molybdopterin oxidoreductase Fe4S4 domain K08357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007766 544.0
TLS3_k127_4977876_1 Elements of external origin K07494 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 445.0
TLS3_k127_4977876_10 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000001555 116.0
TLS3_k127_4977876_11 - - - - 0.00000000000000001121 96.0
TLS3_k127_4977876_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000003864 79.0
TLS3_k127_4977876_13 - - - - 0.00000000007273 68.0
TLS3_k127_4977876_14 hyperosmotic response K04065 - - 0.0000000001452 67.0
TLS3_k127_4977876_15 - - - - 0.0000000121 61.0
TLS3_k127_4977876_16 hyperosmotic response K04065 - - 0.00000001766 57.0
TLS3_k127_4977876_17 Protein of unknown function (DUF3341) - - - 0.00003679 52.0
TLS3_k127_4977876_2 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 378.0
TLS3_k127_4977876_3 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 358.0
TLS3_k127_4977876_4 Mechanosensitive ion channel K16052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008422 314.0
TLS3_k127_4977876_5 permease K03548 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006402 299.0
TLS3_k127_4977876_6 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000885 229.0
TLS3_k127_4977876_7 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000001328 167.0
TLS3_k127_4977876_8 PFAM Peptidase family M28 - - - 0.00000000000000000000000000000000000008069 147.0
TLS3_k127_4977876_9 Bacterial PH domain - - - 0.00000000000000000000000000001494 122.0
TLS3_k127_501789_0 4 iron, 4 sulfur cluster binding K00113,K00176,K05524,K13795,K13796 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3,1.2.7.3 5.816e-196 618.0
TLS3_k127_501789_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 586.0
TLS3_k127_501789_10 PFAM blue (type 1) copper domain protein K00368 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 0.00000000000000000000000000000000000000007279 155.0
TLS3_k127_501789_13 AMP binding - - - 0.00000000000000000000000002946 109.0
TLS3_k127_501789_14 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.00000000000000000000002831 101.0
TLS3_k127_501789_3 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 330.0
TLS3_k127_501789_4 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 306.0
TLS3_k127_501789_5 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 281.0
TLS3_k127_501789_6 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009444 282.0
TLS3_k127_501789_7 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005715 244.0
TLS3_k127_501789_8 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000004029 178.0
TLS3_k127_501789_9 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000008516 177.0
TLS3_k127_5049926_0 cellulose binding - - - 1.216e-235 730.0
TLS3_k127_5049926_1 Protein of unknown function (DUF1579) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 302.0
TLS3_k127_5049926_2 PFAM short chain dehydrogenase - - - 0.000006327 51.0
TLS3_k127_5087212_0 Common central domain of tyrosinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 315.0
TLS3_k127_5087212_1 TupA-like ATPgrasp - - - 0.0000000000000000000000004058 108.0
TLS3_k127_5087212_2 Transposase - - - 0.0000000000000002905 79.0
TLS3_k127_5087212_3 Fibronectin type III domain protein - - - 0.000000007191 64.0
TLS3_k127_5243758_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1409.0
TLS3_k127_5243758_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1390.0
TLS3_k127_5243758_10 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 605.0
TLS3_k127_5243758_11 Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 516.0
TLS3_k127_5243758_12 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 487.0
TLS3_k127_5243758_13 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 484.0
TLS3_k127_5243758_14 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 474.0
TLS3_k127_5243758_15 protein histidine kinase activity K02484,K07640,K07643,K07645,K07649,K19609 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 473.0
TLS3_k127_5243758_16 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 443.0
TLS3_k127_5243758_17 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 356.0
TLS3_k127_5243758_18 Pfam:DUF989 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 349.0
TLS3_k127_5243758_19 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 324.0
TLS3_k127_5243758_2 ABC transporter K06158 - - 2.508e-310 959.0
TLS3_k127_5243758_20 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 321.0
TLS3_k127_5243758_21 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002982 267.0
TLS3_k127_5243758_22 ferredoxin-thioredoxin reductase activity K17892 GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015979,GO:0016491,GO:0016730,GO:0022900,GO:0030385,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 1.8.7.2 0.00000000000000000000000000000000000000000000000000000000000000000001021 237.0
TLS3_k127_5243758_23 - - - - 0.000000000000000000000000000000000000000000000000000000000000001159 220.0
TLS3_k127_5243758_24 Belongs to the HesB IscA family K15724 - - 0.00000000000000000000000000000000000000000000000000000000008135 204.0
TLS3_k127_5243758_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000004706 207.0
TLS3_k127_5243758_26 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000006111 199.0
TLS3_k127_5243758_29 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000000000000000000000000003846 187.0
TLS3_k127_5243758_3 von Willebrand factor (vWF) type A domain K02448 - - 7.067e-306 966.0
TLS3_k127_5243758_30 Ferredoxin K04755 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 - 0.0000000000000000000000000000000000000000000000000008649 186.0
TLS3_k127_5243758_31 synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000001422 186.0
TLS3_k127_5243758_32 Ecdysteroid kinase - - - 0.00000000000000000000000000000000000000000000000009186 192.0
TLS3_k127_5243758_33 CYTH - - - 0.0000000000000000000000000000000000000000000000001878 195.0
TLS3_k127_5243758_34 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.0000000000000000000000000000000000000001497 152.0
TLS3_k127_5243758_35 Helix-turn-helix K21498 - - 0.0000000000000000000000000000000000000006546 150.0
TLS3_k127_5243758_36 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000000000000000002847 147.0
TLS3_k127_5243758_37 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.000000000000000000000000000000000001526 143.0
TLS3_k127_5243758_38 WYL domain K13572 - - 0.000000000000000004837 86.0
TLS3_k127_5243758_39 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000005757 77.0
TLS3_k127_5243758_4 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 2.262e-245 761.0
TLS3_k127_5243758_40 - - - - 0.0000002744 60.0
TLS3_k127_5243758_5 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 9.298e-231 720.0
TLS3_k127_5243758_6 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 7.825e-227 708.0
TLS3_k127_5243758_7 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 6.062e-209 670.0
TLS3_k127_5243758_8 cytochrome p450 - - - 4.896e-205 647.0
TLS3_k127_5243758_9 DNA polymerase beta thumb - - - 1.857e-196 627.0
TLS3_k127_526248_0 amine dehydrogenase activity - - - 0.0 1718.0
TLS3_k127_526248_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1002.0
TLS3_k127_526248_10 L-allo-threonine aldolase activity K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000673 476.0
TLS3_k127_526248_11 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 420.0
TLS3_k127_526248_12 protein-(glutamine-N5) methyltransferase activity K00543,K16130,K18896,K18897,K21515 - 2.1.1.156,2.1.1.157,2.1.1.209,2.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 396.0
TLS3_k127_526248_13 ATPase activity K02013,K02028,K05776 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21,3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 397.0
TLS3_k127_526248_14 Belongs to the pseudouridine synthase RsuA family K06178,K06181,K06182 - 5.4.99.20,5.4.99.21,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 388.0
TLS3_k127_526248_15 nucleotidyltransferase activity K17882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 334.0
TLS3_k127_526248_17 RNA-DNA hybrid ribonuclease activity K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000001158 278.0
TLS3_k127_526248_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.114e-301 930.0
TLS3_k127_526248_20 Protein of unknown function (DUF2959) - - - 0.000000000000000000000000000000000000000000000000000000000003191 215.0
TLS3_k127_526248_21 Cytochrome c mono- and diheme variants - - - 0.00000000000000000000000000000000000000000000000000000002811 201.0
TLS3_k127_526248_23 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.0000000000000000000000000000000000000000000002762 173.0
TLS3_k127_526248_25 Belongs to the peptidase S16 family K07177 - - 0.000001867 59.0
TLS3_k127_526248_26 PFAM FUN14 family - - - 0.00003667 52.0
TLS3_k127_526248_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 2.622e-268 832.0
TLS3_k127_526248_4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.692e-267 833.0
TLS3_k127_526248_5 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 8.747e-205 643.0
TLS3_k127_526248_6 ATP:ADP antiporter activity K03301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009792 607.0
TLS3_k127_526248_7 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 558.0
TLS3_k127_526248_8 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K00387 - 1.8.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 545.0
TLS3_k127_526248_9 D-gluconate metabolic process K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 529.0
TLS3_k127_5280197_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 370.0
TLS3_k127_5280197_1 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008018 254.0
TLS3_k127_5280197_2 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000000000000000000000000000007013 221.0
TLS3_k127_5337692_0 Protein involved in outer membrane biogenesis - - - 1.583e-245 790.0
TLS3_k127_5337692_1 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 387.0
TLS3_k127_5337692_2 protein homooligomerization - - - 0.000000000000000000000000000000000000000000000001265 176.0
TLS3_k127_5337692_3 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000001942 188.0
TLS3_k127_5337692_4 membrane - - - 0.00000000000000000000000000000000000000001383 156.0
TLS3_k127_5337692_5 helicase activity K03466,K12217 - - 0.00000000006109 64.0
TLS3_k127_5337692_6 Protein of unknown function DUF72 - - - 0.00000004563 59.0
TLS3_k127_5379560_0 NADH dehydrogenase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 445.0
TLS3_k127_5379560_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 440.0
TLS3_k127_5379560_2 - - - - 0.00000000000000000000000000000000001077 145.0
TLS3_k127_5379560_3 - - - - 0.0000000000000000000000000000000001535 138.0
TLS3_k127_5379560_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000002157 138.0
TLS3_k127_5379560_5 Protein of unknown function DUF72 - - - 0.000000000000000000001718 101.0
TLS3_k127_5379560_7 Superinfection immunity protein - - - 0.000000000167 64.0
TLS3_k127_5379560_9 Protein of unknown function DUF72 - - - 0.000007176 55.0
TLS3_k127_5402388_0 response regulator K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 587.0
TLS3_k127_550226_0 thymidylate synthase (FAD) activity K03465 - 2.1.1.148 1.023e-259 807.0
TLS3_k127_550226_1 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 572.0
TLS3_k127_550226_3 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009544 428.0
TLS3_k127_550226_5 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - 0.000000000000000000000000000001434 123.0
TLS3_k127_550226_7 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000007836 102.0
TLS3_k127_5586944_0 thiamine transport K02011 - - 2.44e-221 697.0
TLS3_k127_5586944_1 Lecithin:cholesterol acyltransferase - - - 4.662e-214 702.0
TLS3_k127_5586944_10 Protein of unknown function (DUF4231) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000102 237.0
TLS3_k127_5586944_11 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000001204 236.0
TLS3_k127_5586944_12 bacteriocin transport K03561,K03562 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000002747 206.0
TLS3_k127_5586944_13 biopolymer transport protein K03559 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000009769 171.0
TLS3_k127_5586944_14 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000002035 174.0
TLS3_k127_5586944_15 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000003891 156.0
TLS3_k127_5586944_16 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K03832 - - 0.000000000000000000000000000000005639 139.0
TLS3_k127_5586944_17 cellulose binding - - - 0.00000000000000000000000001026 109.0
TLS3_k127_5586944_2 iron ion homeostasis K02012 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 509.0
TLS3_k127_5586944_3 ATPase activity K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 501.0
TLS3_k127_5586944_4 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299,K03281 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 491.0
TLS3_k127_5586944_5 Caspase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 382.0
TLS3_k127_5586944_6 iron ion homeostasis K07165 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 319.0
TLS3_k127_5586944_7 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 293.0
TLS3_k127_5586944_8 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008548 267.0
TLS3_k127_5608719_0 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.0 1598.0
TLS3_k127_5608719_1 type I restriction-modification system K03427 - 2.1.1.72 0.0 1249.0
TLS3_k127_5608719_2 Protein of unknown function DUF262 - - - 9.007e-246 775.0
TLS3_k127_5608719_3 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 355.0
TLS3_k127_5608719_4 type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.0000000000000000000000000000000000000000000000000000000001115 220.0
TLS3_k127_5608719_5 PFAM MgtE intracellular K02383 - - 0.0000000000000000000000000000009682 126.0
TLS3_k127_5608719_6 PFAM plasmid stabilization system - - - 0.0000000000000004465 81.0
TLS3_k127_5608719_7 - - - - 0.00000000000003941 74.0
TLS3_k127_5610249_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1637.0
TLS3_k127_5610249_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 564.0
TLS3_k127_5610249_10 PFAM OmpA MotB domain protein K02557 - - 0.00000000000000000003083 100.0
TLS3_k127_5610249_11 Protoglobin - - - 0.000000418 53.0
TLS3_k127_5610249_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 546.0
TLS3_k127_5610249_3 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 479.0
TLS3_k127_5610249_4 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 299.0
TLS3_k127_5610249_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000000000000000000001734 230.0
TLS3_k127_5610249_7 SprT-like family K02742 - - 0.000000000000000000000000000000000000000000000000000006557 198.0
TLS3_k127_5610249_8 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000000007399 169.0
TLS3_k127_5610249_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000007986 102.0
TLS3_k127_5626572_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0 3018.0
TLS3_k127_5626572_1 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0 2875.0
TLS3_k127_5626572_10 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 359.0
TLS3_k127_5626572_11 Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 334.0
TLS3_k127_5626572_12 Peptidyl-prolyl cis-trans isomerase K01802,K03772,K03773 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002342 317.0
TLS3_k127_5626572_13 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 317.0
TLS3_k127_5626572_14 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 289.0
TLS3_k127_5626572_16 ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000005502 224.0
TLS3_k127_5626572_17 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000009243 228.0
TLS3_k127_5626572_19 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000002052 133.0
TLS3_k127_5626572_2 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0 1635.0
TLS3_k127_5626572_20 - - - - 0.0000000000000000000000002525 109.0
TLS3_k127_5626572_21 Memo-like protein K06990 - - 0.0000000000000000000001197 97.0
TLS3_k127_5626572_22 - - - - 0.000000000000000156 88.0
TLS3_k127_5626572_23 - - - - 0.00000000000003556 76.0
TLS3_k127_5626572_26 Vitamin K epoxide reductase family - - - 0.00008509 44.0
TLS3_k127_5626572_27 Sigma-54 interaction domain K10126 - - 0.0001224 52.0
TLS3_k127_5626572_3 Histidine kinase - - - 1.963e-303 945.0
TLS3_k127_5626572_4 transmembrane transporter activity K03535 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 553.0
TLS3_k127_5626572_5 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 496.0
TLS3_k127_5626572_6 serine-type endopeptidase activity K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 458.0
TLS3_k127_5626572_7 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 441.0
TLS3_k127_5626572_8 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 441.0
TLS3_k127_5626572_9 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 382.0
TLS3_k127_566163_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.0 1182.0
TLS3_k127_566163_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0 1050.0
TLS3_k127_566163_10 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 433.0
TLS3_k127_566163_11 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 415.0
TLS3_k127_566163_12 - K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 376.0
TLS3_k127_566163_13 TOBE domain K10111 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 376.0
TLS3_k127_566163_14 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 354.0
TLS3_k127_566163_15 PFAM binding-protein-dependent transport systems inner membrane component K02026,K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 349.0
TLS3_k127_566163_17 Binding-protein-dependent transport system inner membrane component K02025,K05814,K17316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 291.0
TLS3_k127_566163_18 Cadherin-like beta sandwich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 306.0
TLS3_k127_566163_19 YceI-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006476 273.0
TLS3_k127_566163_2 - K01992 - - 1.006e-234 736.0
TLS3_k127_566163_20 Cadherin-like beta sandwich domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006909 297.0
TLS3_k127_566163_22 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000009994 227.0
TLS3_k127_566163_23 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000001714 226.0
TLS3_k127_566163_24 Cadherin-like beta sandwich domain - - - 0.00000000000000000000000000000000000000000000000000000000000001404 236.0
TLS3_k127_566163_25 TAP-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000006173 222.0
TLS3_k127_566163_26 response regulator, receiver K02479 - - 0.0000000000000000000000000000000000000000000000000000000004289 213.0
TLS3_k127_566163_27 peptidoglycan binding K03642 - - 0.000000000000000000000000000000000000000000000000006989 188.0
TLS3_k127_566163_29 Cadherin-like beta sandwich domain - - - 0.00000000000000000000000000002897 134.0
TLS3_k127_566163_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.068e-233 732.0
TLS3_k127_566163_30 Domain of unknown function (DUF4112) - - - 0.000000000000000000001761 101.0
TLS3_k127_566163_31 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000001336 85.0
TLS3_k127_566163_32 domain, Protein K20276 - - 0.000000000000004543 89.0
TLS3_k127_566163_33 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000008457 73.0
TLS3_k127_566163_34 von willebrand factor, type A - - - 0.0000000000008892 83.0
TLS3_k127_566163_37 protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain - - - 0.000000008299 68.0
TLS3_k127_566163_38 Cadherin-like beta sandwich domain - - - 0.0000002641 62.0
TLS3_k127_566163_4 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 581.0
TLS3_k127_566163_40 macromolecule localization K01421,K01992,K09690 - - 0.0000006825 53.0
TLS3_k127_566163_42 - - - - 0.00006949 48.0
TLS3_k127_566163_5 alcohol dehydrogenase K00060,K07777 - 1.1.1.103,2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 574.0
TLS3_k127_566163_6 Histidine kinase K00060,K07777 - 1.1.1.103,2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 562.0
TLS3_k127_566163_8 ATPase activity K01990,K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 475.0
TLS3_k127_566163_9 ABC-type sugar transport system periplasmic component K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 459.0
TLS3_k127_5663383_0 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009591 261.0
TLS3_k127_5663383_1 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000001129 210.0
TLS3_k127_566934_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1395.0
TLS3_k127_566934_1 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 7.361e-240 749.0
TLS3_k127_566934_10 Alpha/beta hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 352.0
TLS3_k127_566934_11 DNA ligase (ATP) activity K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 348.0
TLS3_k127_566934_12 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 338.0
TLS3_k127_566934_14 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001942 268.0
TLS3_k127_566934_15 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001185 253.0
TLS3_k127_566934_16 Dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000136 242.0
TLS3_k127_566934_17 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000004504 233.0
TLS3_k127_566934_18 - K07184,K07777,K12065,K13527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000009684 205.0
TLS3_k127_566934_19 thiolester hydrolase activity K06889,K07397 - - 0.00000000000000000000000000000000000000000000000000000009879 203.0
TLS3_k127_566934_2 Bacterial regulatory protein, Fis family K07715 - - 2.345e-238 744.0
TLS3_k127_566934_20 Membrane - - - 0.0000000000000000000000000000000000000000000000000002339 196.0
TLS3_k127_566934_21 protein conserved in cyanobacteria - - - 0.0000000000000000000000000000000000000000000000000009913 189.0
TLS3_k127_566934_23 - - - - 0.00000000000000000000000000000000000000000000000009954 189.0
TLS3_k127_566934_25 Protein of unknown function (DUF423) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000004049 143.0
TLS3_k127_566934_26 - - - - 0.0000000000000000000000000000000000007996 149.0
TLS3_k127_566934_27 DNA integration - - - 0.000000000000000000000000000000001645 132.0
TLS3_k127_566934_28 DNA integration - - - 0.000000000000000000000000000000005591 129.0
TLS3_k127_566934_29 sequence-specific DNA binding - - - 0.00000000000000000000000000000008577 125.0
TLS3_k127_566934_3 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 2.122e-225 711.0
TLS3_k127_566934_30 AP2 domain - - - 0.0000000000000000000000000000001404 128.0
TLS3_k127_566934_31 PIN domain - - - 0.000000000000000000000000000001035 126.0
TLS3_k127_566934_33 Polymer-forming cytoskeletal - - - 0.00000000000000000000000001062 116.0
TLS3_k127_566934_35 DNA integration - - - 0.00000000000000000000001021 101.0
TLS3_k127_566934_36 cheY-homologous receiver domain - - - 0.00000000000000000000003391 103.0
TLS3_k127_566934_37 pyridoxamine 5-phosphate - - - 0.00000000000000000000004527 104.0
TLS3_k127_566934_39 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000009533 97.0
TLS3_k127_566934_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 592.0
TLS3_k127_566934_40 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000001014 95.0
TLS3_k127_566934_41 - - - - 0.0000000000000000003385 94.0
TLS3_k127_566934_42 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000000002443 87.0
TLS3_k127_566934_44 helix_turn_helix, Lux Regulon - - - 0.000000000000002988 78.0
TLS3_k127_566934_46 Evidence 2b Function of strongly homologous gene K07497 - - 0.00000000001482 66.0
TLS3_k127_566934_48 GYD domain - - - 0.00000000004396 68.0
TLS3_k127_566934_49 Protein of unknown function DUF72 - - - 0.00000000004445 66.0
TLS3_k127_566934_5 Monoamine oxidase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 574.0
TLS3_k127_566934_53 nuclease - - - 0.0000002327 52.0
TLS3_k127_566934_54 PFAM nuclease (SNase domain protein) - - - 0.000001334 57.0
TLS3_k127_566934_57 His Kinase A (phosphoacceptor) domain - - - 0.00005092 53.0
TLS3_k127_566934_58 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0001377 52.0
TLS3_k127_566934_59 Helix-turn-helix domain - - - 0.0002223 43.0
TLS3_k127_566934_6 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 533.0
TLS3_k127_566934_60 Sigma-54 interaction domain K10126 - - 0.0005356 50.0
TLS3_k127_566934_7 flavin-nucleotide-binding protein structurally related to pyridoxine 5-phosphate oxidase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 445.0
TLS3_k127_566934_8 HsdM N-terminal domain K03427 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 407.0
TLS3_k127_566934_9 ATP dependent DNA ligase C terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 385.0
TLS3_k127_5738660_0 Hemolysin-type calcium-binding - - - 0.0 1195.0
TLS3_k127_5738660_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007612 351.0
TLS3_k127_5738660_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218,K03437,K03501 - 2.1.1.170,2.1.1.185 0.000000000000000000000000000000000000000000000000000000001719 210.0
TLS3_k127_5738660_3 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000000000000198 167.0
TLS3_k127_5774827_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 550.0
TLS3_k127_5774827_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000001417 120.0
TLS3_k127_5875812_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1654.0
TLS3_k127_5875812_1 transmembrane transporter activity K18138 - - 0.0 1635.0
TLS3_k127_5875812_10 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000006316 195.0
TLS3_k127_5875812_11 - - - - 0.000000000000000000000000000000000000000005611 158.0
TLS3_k127_5875812_12 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000039 136.0
TLS3_k127_5875812_2 sigma factor activity K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 608.0
TLS3_k127_5875812_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 461.0
TLS3_k127_5875812_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 417.0
TLS3_k127_5875812_5 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007052 336.0
TLS3_k127_5875812_6 response regulator K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006862 271.0
TLS3_k127_5875812_7 response regulator K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004228 259.0
TLS3_k127_5875812_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001174 267.0
TLS3_k127_5875812_9 Histidine kinase K07683 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000005723 263.0
TLS3_k127_6027410_0 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0 1566.0
TLS3_k127_6027410_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 5.972e-288 891.0
TLS3_k127_6027410_10 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 377.0
TLS3_k127_6027410_11 Pilus assembly protein PilX K07140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 387.0
TLS3_k127_6027410_12 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 344.0
TLS3_k127_6027410_13 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 340.0
TLS3_k127_6027410_14 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 328.0
TLS3_k127_6027410_15 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 306.0
TLS3_k127_6027410_16 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 297.0
TLS3_k127_6027410_17 self proteolysis - - - 0.000000000000000000000000000000000000000000000000000000000000000001457 239.0
TLS3_k127_6027410_18 PAP2 superfamily K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000004639 216.0
TLS3_k127_6027410_19 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000007617 198.0
TLS3_k127_6027410_2 Type II/IV secretion system protein K02454,K02652 - - 1.766e-248 780.0
TLS3_k127_6027410_20 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000003656 184.0
TLS3_k127_6027410_21 bacterial (prokaryotic) histone like domain K04764 - - 0.00000000000000000000000000000000000000000000003299 170.0
TLS3_k127_6027410_22 pilus assembly protein PilW K02672 - - 0.000000000000000000000000000000000000000000001758 181.0
TLS3_k127_6027410_23 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000001506 163.0
TLS3_k127_6027410_24 lipid-A-disaccharide synthase activity - - - 0.0000000000000000000000000000000000000001457 151.0
TLS3_k127_6027410_25 pilus assembly protein PilW K02672 - - 0.000000000000000000000000000000000006942 147.0
TLS3_k127_6027410_26 Putative Competence protein ComGF K02246,K02248 - - 0.00000000000000000000000000000000003741 143.0
TLS3_k127_6027410_28 response regulator K03413 - - 0.000000000000000000000000000004381 121.0
TLS3_k127_6027410_29 protein transport across the cell outer membrane K02457,K02672,K08084,K08085 - - 0.0000000000000000000000000614 112.0
TLS3_k127_6027410_3 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 9.42e-222 700.0
TLS3_k127_6027410_30 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000761 111.0
TLS3_k127_6027410_31 type IV pilus modification protein PilV K02671,K02681,K10927 - - 0.0000000000000000000000001804 113.0
TLS3_k127_6027410_33 PFAM Mo-dependent nitrogenase K00232 - 1.3.3.6 0.000002665 55.0
TLS3_k127_6027410_35 Prokaryotic N-terminal methylation motif K02457 - - 0.0004016 49.0
TLS3_k127_6027410_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 5.555e-206 655.0
TLS3_k127_6027410_5 peptide catabolic process - - - 2.212e-198 642.0
TLS3_k127_6027410_6 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 591.0
TLS3_k127_6027410_7 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 561.0
TLS3_k127_6027410_8 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 511.0
TLS3_k127_6027410_9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 416.0
TLS3_k127_6042849_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K19585 - - 0.0 1603.0
TLS3_k127_6042849_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0 1035.0
TLS3_k127_6042849_10 Uncharacterised conserved protein (DUF2156) K01163,K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 460.0
TLS3_k127_6042849_11 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 407.0
TLS3_k127_6042849_12 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 393.0
TLS3_k127_6042849_13 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 382.0
TLS3_k127_6042849_14 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009948 382.0
TLS3_k127_6042849_15 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 334.0
TLS3_k127_6042849_16 catechol 2,3-dioxygenase activity K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000115 267.0
TLS3_k127_6042849_17 Protein of unknown function (DUF3015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002763 262.0
TLS3_k127_6042849_18 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000005959 264.0
TLS3_k127_6042849_19 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000002853 257.0
TLS3_k127_6042849_2 Domain of unknown function (DUF4105) - - - 1.184e-310 963.0
TLS3_k127_6042849_20 protein disulfide oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000016 256.0
TLS3_k127_6042849_21 O-acyltransferase activity K00661 - 2.3.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000001196 252.0
TLS3_k127_6042849_22 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002286 246.0
TLS3_k127_6042849_26 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000001121 159.0
TLS3_k127_6042849_27 Glycine-zipper domain - - - 0.00000000000000000000000000000000000003468 147.0
TLS3_k127_6042849_29 Iron-binding zinc finger CDGSH type - - - 0.0000000000000000000000000000000001669 134.0
TLS3_k127_6042849_3 Glycosyl hydrolases family 15 - - - 2.862e-277 863.0
TLS3_k127_6042849_30 glutathione transferase activity K00799 - 2.5.1.18 0.0000000000000000000000000002806 117.0
TLS3_k127_6042849_31 PFAM NADPH-dependent FMN reductase K19784 - - 0.000000000000000000009907 97.0
TLS3_k127_6042849_32 DUF167 K09131 - - 0.00000000000000000006287 94.0
TLS3_k127_6042849_33 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.000000000000000007957 85.0
TLS3_k127_6042849_35 - - - - 0.000000000000005465 81.0
TLS3_k127_6042849_36 - - - - 0.000000000008292 73.0
TLS3_k127_6042849_37 Cytochrome c - - - 0.00000000003386 68.0
TLS3_k127_6042849_39 - - - - 0.000000001175 63.0
TLS3_k127_6042849_4 Lysine-2,3-aminomutase K01843 - 5.4.3.2 6.796e-208 654.0
TLS3_k127_6042849_41 - - - - 0.0000006938 56.0
TLS3_k127_6042849_5 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 4.498e-198 625.0
TLS3_k127_6042849_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 602.0
TLS3_k127_6042849_7 Sigma-54 interaction domain K15836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005766 516.0
TLS3_k127_6042849_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 463.0
TLS3_k127_6042849_9 Associated with various cellular activities K04748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 446.0
TLS3_k127_6097777_0 HWE histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 474.0
TLS3_k127_6097777_1 response regulator K02479,K07684,K07685 - - 0.00000000000000000000000000000000002972 141.0
TLS3_k127_6097777_2 response regulator K02479,K07684,K07685 - - 0.00000000000000000000000000000000004618 143.0
TLS3_k127_6097777_3 - - - - 0.0000000000000257 79.0
TLS3_k127_6097777_4 - - - - 0.0008002 42.0
TLS3_k127_6203083_0 RNA secondary structure unwinding K03724 - - 0.0 1960.0
TLS3_k127_6203083_1 glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 369.0
TLS3_k127_6217252_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1520.0
TLS3_k127_6217252_1 Phosphate acyltransferases K01897,K05939 - 2.3.1.40,6.2.1.20,6.2.1.3 0.0 1484.0
TLS3_k127_6217252_10 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 443.0
TLS3_k127_6217252_11 poly(3-hydroxybutyrate) depolymerase activity K07019 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 432.0
TLS3_k127_6217252_12 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 407.0
TLS3_k127_6217252_13 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000556 392.0
TLS3_k127_6217252_14 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 380.0
TLS3_k127_6217252_15 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 334.0
TLS3_k127_6217252_16 thiolester hydrolase activity K06889,K07397 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006418 316.0
TLS3_k127_6217252_17 photosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 308.0
TLS3_k127_6217252_18 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 299.0
TLS3_k127_6217252_19 response regulator K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009797 279.0
TLS3_k127_6217252_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 5.405e-311 962.0
TLS3_k127_6217252_21 glycerophosphoryl diester phosphodiesterase K01113,K01126 - 3.1.3.1,3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000006255 276.0
TLS3_k127_6217252_22 transposition K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007273 250.0
TLS3_k127_6217252_23 photosystem II stabilization K02237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002072 253.0
TLS3_k127_6217252_25 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005063 252.0
TLS3_k127_6217252_26 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000000000000000000000000000005464 241.0
TLS3_k127_6217252_27 Histidine kinase K07683 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000001477 241.0
TLS3_k127_6217252_28 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005068 223.0
TLS3_k127_6217252_29 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000005139 177.0
TLS3_k127_6217252_3 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 3.232e-259 800.0
TLS3_k127_6217252_30 GGDEF domain - - - 0.00000000000000000000000000000000000000000000004257 174.0
TLS3_k127_6217252_31 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000000197 168.0
TLS3_k127_6217252_33 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000001425 146.0
TLS3_k127_6217252_35 Integrase core domain - - - 0.00000000000000000000000000000001402 128.0
TLS3_k127_6217252_36 PFAM plasmid stabilization system - - - 0.00000000000000000001405 94.0
TLS3_k127_6217252_37 cellulase activity K20276 - - 0.0000000000000000001018 99.0
TLS3_k127_6217252_38 transposase activity K07483,K07497 - - 0.000000000000000006066 86.0
TLS3_k127_6217252_39 transposition K07497 - - 0.00000000000000004902 80.0
TLS3_k127_6217252_4 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 4.609e-215 671.0
TLS3_k127_6217252_40 transposase activity K07483,K07497 - - 0.00000000000005627 72.0
TLS3_k127_6217252_41 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.00000000006321 67.0
TLS3_k127_6217252_42 Putative addiction module component - - - 0.000000005175 60.0
TLS3_k127_6217252_44 Glutathione S-transferase, N-terminal domain - - - 0.0005997 43.0
TLS3_k127_6217252_5 mismatched DNA binding K03555 - - 1.636e-202 647.0
TLS3_k127_6217252_6 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 578.0
TLS3_k127_6217252_7 The glycine cleavage system catalyzes the degradation of glycine K00605,K06980,K22086 - 1.5.99.5,2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005297 541.0
TLS3_k127_6217252_8 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 516.0
TLS3_k127_6217252_9 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 486.0
TLS3_k127_6221751_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1716.0
TLS3_k127_6221751_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 1.484e-228 715.0
TLS3_k127_6221751_10 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003675 250.0
TLS3_k127_6221751_13 Magnesium transport protein CorA - - - 0.0004585 44.0
TLS3_k127_6221751_2 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 587.0
TLS3_k127_6221751_3 L-2-hydroxyglutarate oxidase LhgO K15736 GO:0000166,GO:0003674,GO:0003824,GO:0003973,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0016899,GO:0034419,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005664 568.0
TLS3_k127_6221751_4 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009964 525.0
TLS3_k127_6221751_5 chaperone-mediated protein folding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 450.0
TLS3_k127_6221751_6 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000701 374.0
TLS3_k127_6221751_7 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 349.0
TLS3_k127_6221751_8 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 306.0
TLS3_k127_6221751_9 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 293.0
TLS3_k127_6231856_0 radical SAM domain protein - - - 0.0 1140.0
TLS3_k127_6231856_1 radical SAM domain protein - - - 0.0 1106.0
TLS3_k127_6231856_11 - - - - 0.0000000000001015 77.0
TLS3_k127_6231856_12 - - - - 0.00003926 48.0
TLS3_k127_6231856_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family K18534 - 2.1.1.295 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 551.0
TLS3_k127_6231856_3 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 489.0
TLS3_k127_6231856_4 isomerase activity K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 436.0
TLS3_k127_6231856_5 Mo-molybdopterin cofactor metabolic process K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000152 265.0
TLS3_k127_6231856_6 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000469 258.0
TLS3_k127_6231856_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000000115 202.0
TLS3_k127_6231856_8 Protein of unknown function (DUF3800) - - - 0.000000000000000000000000000001802 128.0
TLS3_k127_6231856_9 - - - - 0.00000000000000000002201 93.0
TLS3_k127_6243237_0 belongs to the aldehyde dehydrogenase family K00294,K13821 - 1.2.1.88,1.5.5.2 0.0 1219.0
TLS3_k127_6243237_1 Protein involved in outer membrane biogenesis K07290 - - 0.0 1182.0
TLS3_k127_6243237_10 negative regulation of translational initiation K05554,K14670,K15886 - 2.3.1.235 0.000000000000000000000000000000000000000000000002431 181.0
TLS3_k127_6243237_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.000000000000000000000000000000000000000002504 156.0
TLS3_k127_6243237_12 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000749 158.0
TLS3_k127_6243237_16 DNA-sulfur modification-associated - - - 0.00000004147 65.0
TLS3_k127_6243237_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 1.765e-255 798.0
TLS3_k127_6243237_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 481.0
TLS3_k127_6243237_4 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 431.0
TLS3_k127_6243237_5 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 428.0
TLS3_k127_6243237_6 methyltransferase K16129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 349.0
TLS3_k127_6243237_7 PFAM MscS Mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003679 304.0
TLS3_k127_6243237_8 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000002969 242.0
TLS3_k127_6243237_9 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000001741 233.0
TLS3_k127_6263186_0 Proteasomal ATPase OB/ID domain K13527 - - 4.169e-272 847.0
TLS3_k127_6263186_1 Pup-ligase protein K20814 - 3.5.1.119 3.954e-264 820.0
TLS3_k127_6263186_10 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000523 198.0
TLS3_k127_6263186_11 bis(5'-adenosyl)-triphosphatase activity - - - 0.000000000000000000000000000000000000000000000000009888 183.0
TLS3_k127_6263186_12 May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes - - - 0.00000000000000000000001433 102.0
TLS3_k127_6263186_13 Adenylate Guanylate cyclase K01768 - 4.6.1.1 0.000004684 59.0
TLS3_k127_6263186_2 Pup-ligase protein K13571 - 6.3.1.19 6.495e-233 729.0
TLS3_k127_6263186_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K08070 - 1.3.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 529.0
TLS3_k127_6263186_4 Proteasome subunit K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 407.0
TLS3_k127_6263186_5 PFAM metal-dependent phosphohydrolase, HD sub domain K01524,K07012 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 385.0
TLS3_k127_6263186_6 Proteasome subunit K03432 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 321.0
TLS3_k127_6263186_7 Evidence 5 No homology to any previously reported sequences K02450,K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 296.0
TLS3_k127_6263186_9 Transposase - - - 0.00000000000000000000000000000000000000000000000000000004885 199.0
TLS3_k127_6309579_0 Protein of unknown function, DUF255 K06888 - - 0.0 1551.0
TLS3_k127_6309579_1 Evidence 4 Homologs of previously reported genes of K07114,K08309 - - 1.353e-249 794.0
TLS3_k127_6309579_10 peptidyl-tyrosine sulfation K02450 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 382.0
TLS3_k127_6309579_11 protein tyrosine kinase activity K08252 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005684 353.0
TLS3_k127_6309579_12 heat shock protein binding K05516,K05801,K18481 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001871 273.0
TLS3_k127_6309579_13 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001954 274.0
TLS3_k127_6309579_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006136 256.0
TLS3_k127_6309579_15 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000001624 238.0
TLS3_k127_6309579_16 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000000000003381 231.0
TLS3_k127_6309579_18 arsenate reductase (glutaredoxin) activity K00537 - 1.20.4.1 0.00000000000000000000000000000000000000000000632 168.0
TLS3_k127_6309579_2 extracellular polysaccharide biosynthetic process K07011,K16706 - - 6.286e-248 778.0
TLS3_k127_6309579_20 phosphohistidine phosphatase, SixA K08296 - - 0.00000000000000000000000000000000000005326 149.0
TLS3_k127_6309579_21 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000005533 150.0
TLS3_k127_6309579_22 peptidyl-tyrosine sulfation K02450 - - 0.00000000000000000000000000000000007857 139.0
TLS3_k127_6309579_23 nuclease activity - - - 0.0000000000000000000000000000006882 125.0
TLS3_k127_6309579_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 4.359e-244 763.0
TLS3_k127_6309579_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01524,K07012 - 3.6.1.11,3.6.1.40 2.644e-213 674.0
TLS3_k127_6309579_5 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 1.034e-204 640.0
TLS3_k127_6309579_6 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K01791,K02851 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008963,GO:0009058,GO:0009059,GO:0009103,GO:0009246,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046378,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.8.33,2.7.8.35,5.1.3.14 8.236e-194 618.0
TLS3_k127_6309579_7 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 576.0
TLS3_k127_6309579_8 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006133 489.0
TLS3_k127_6309579_9 Protein conserved in bacteria K20920 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008308 417.0
TLS3_k127_6325374_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 3168.0
TLS3_k127_6325374_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.261e-271 854.0
TLS3_k127_6325374_10 Protein of unknown function (DUF3309) - - - 0.000000000002419 68.0
TLS3_k127_6325374_11 - - - - 0.00000004045 55.0
TLS3_k127_6325374_12 helix_turn_helix multiple antibiotic resistance protein - - - 0.000001851 55.0
TLS3_k127_6325374_14 - - - - 0.00009384 47.0
TLS3_k127_6325374_15 YtxH-like protein - - - 0.0002967 48.0
TLS3_k127_6325374_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.263e-194 623.0
TLS3_k127_6325374_4 ribosomal large subunit export from nucleus - - - 0.00000000000000000000000000000000000000000001011 168.0
TLS3_k127_6325374_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.0000000000000000000000000000000000000002667 156.0
TLS3_k127_6325374_6 IMP dehydrogenase activity K09137 - - 0.0000000000000000000000000000000000000007883 152.0
TLS3_k127_6325374_7 Transglycosylase associated protein - - - 0.00000000000000000000000000361 112.0
TLS3_k127_6325374_8 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000004705 104.0
TLS3_k127_6325374_9 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000001449 83.0
TLS3_k127_6330125_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007266 531.0
TLS3_k127_6330125_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000004915 196.0
TLS3_k127_6330125_2 Hydrolase Family 16 - - - 0.00000000000000000000000008273 115.0
TLS3_k127_6330125_3 Hydrolase Family 16 - - - 0.00001975 47.0
TLS3_k127_6357858_0 phosphorelay signal transduction system K02481,K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006958 471.0
TLS3_k127_6357858_1 Multicopper oxidase K00368,K22349 - 1.16.3.3,1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 462.0
TLS3_k127_6357858_2 SMART Metal-dependent phosphohydrolase, HD region - - - 0.00000000000000000000000000000000000000000000000000002877 197.0
TLS3_k127_6357858_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000001338 185.0
TLS3_k127_6357858_4 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000000006544 178.0
TLS3_k127_6357858_5 type III restriction protein res subunit K01153 - 3.1.21.3 0.00000000000000000000000000000000000000000838 156.0
TLS3_k127_6368440_0 metallopeptidase activity K01993,K13408,K16922 - - 4.071e-274 865.0
TLS3_k127_6368440_1 Baseplate J-like protein - - - 7.65e-250 797.0
TLS3_k127_6368440_10 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008561 521.0
TLS3_k127_6368440_11 PFAM ABC transporter related K06148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 509.0
TLS3_k127_6368440_12 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 489.0
TLS3_k127_6368440_13 Late control gene D protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 467.0
TLS3_k127_6368440_14 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004171 481.0
TLS3_k127_6368440_15 Protein of unknown function (DUF4255) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 458.0
TLS3_k127_6368440_16 Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 447.0
TLS3_k127_6368440_17 electron transfer activity K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 415.0
TLS3_k127_6368440_18 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 378.0
TLS3_k127_6368440_19 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 359.0
TLS3_k127_6368440_2 Major facilitator Superfamily K08218 - - 5.191e-245 767.0
TLS3_k127_6368440_20 chlorophyll binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 376.0
TLS3_k127_6368440_21 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 348.0
TLS3_k127_6368440_22 RimK-like ATP-grasp domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 343.0
TLS3_k127_6368440_23 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 321.0
TLS3_k127_6368440_24 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 308.0
TLS3_k127_6368440_25 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K00567,K01247 - 2.1.1.63,3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 303.0
TLS3_k127_6368440_26 domain, Protein K13735,K15125,K15531 - 3.2.1.156 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000792 302.0
TLS3_k127_6368440_27 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004342 274.0
TLS3_k127_6368440_28 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000004069 260.0
TLS3_k127_6368440_29 Baseplate assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000119 255.0
TLS3_k127_6368440_3 homolog of phage Mu protein gp47 - - - 5.584e-225 727.0
TLS3_k127_6368440_30 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000002578 260.0
TLS3_k127_6368440_31 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000000162 219.0
TLS3_k127_6368440_33 PFAM T4 bacteriophage base plate protein - - - 0.0000000000000000000000000000000000000000000000000002715 193.0
TLS3_k127_6368440_34 - - - - 0.00000000000000000000000000000000000000000005722 172.0
TLS3_k127_6368440_35 Gene 25-like lysozyme K06903 - - 0.00000000000000000000000000000000000000004018 160.0
TLS3_k127_6368440_36 - - - - 0.00000000000000000000000000000000000000007863 153.0
TLS3_k127_6368440_37 LysM domain - - - 0.0000000000000000000000000000000000007644 144.0
TLS3_k127_6368440_38 positive regulation of type IV pilus biogenesis K07343 - - 0.000000000000000000000000000000007199 129.0
TLS3_k127_6368440_39 helix_turn_helix, Lux Regulon K02479 - - 0.0000000000000000000000006791 113.0
TLS3_k127_6368440_4 efflux transmembrane transporter activity K03287 - - 5.294e-211 667.0
TLS3_k127_6368440_40 Evidence 2b Function of strongly homologous gene K18139 - - 0.0000000000000431 72.0
TLS3_k127_6368440_41 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000002003 73.0
TLS3_k127_6368440_43 GDSL-like Lipase/Acylhydrolase - - - 0.000000000006323 73.0
TLS3_k127_6368440_45 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K02479,K07692 - - 0.00008467 50.0
TLS3_k127_6368440_5 Phage tail sheath C-terminal domain K06907 - - 1.708e-210 666.0
TLS3_k127_6368440_6 symporter activity K03307,K14387 - - 7.644e-210 662.0
TLS3_k127_6368440_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 8.077e-205 648.0
TLS3_k127_6368440_8 PFAM ATPase family associated with various cellular activities (AAA) - - - 2.03e-202 650.0
TLS3_k127_6368440_9 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 606.0
TLS3_k127_6542604_0 PFAM Copper resistance D K07245 - - 3.204e-247 782.0
TLS3_k127_6542604_1 TonB-dependent receptor K16091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 310.0
TLS3_k127_6542604_10 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.000000000004115 67.0
TLS3_k127_6542604_11 - - - - 0.000007653 50.0
TLS3_k127_6542604_2 ferroxidase activity K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 291.0
TLS3_k127_6542604_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001495 236.0
TLS3_k127_6542604_4 ferroxidase activity K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000004377 231.0
TLS3_k127_6542604_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000006762 219.0
TLS3_k127_6542604_6 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000003413 207.0
TLS3_k127_6542604_7 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000001681 186.0
TLS3_k127_6542604_8 PFAM Copper resistance protein CopC K07156 - - 0.000000000000000000000000000000000000000000003323 169.0
TLS3_k127_6542604_9 - - - - 0.00000000000000000000000000000000000000000001888 171.0
TLS3_k127_6543651_0 GHKL domain K13598 - 2.7.13.3 0.0 1151.0
TLS3_k127_6543651_1 - - - - 1.112e-273 850.0
TLS3_k127_6543651_10 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 519.0
TLS3_k127_6543651_11 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009173 495.0
TLS3_k127_6543651_12 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 490.0
TLS3_k127_6543651_13 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 455.0
TLS3_k127_6543651_14 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008467 454.0
TLS3_k127_6543651_15 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 431.0
TLS3_k127_6543651_16 transmembrane transport K02532,K05820,K08167,K08218,K08369 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 433.0
TLS3_k127_6543651_17 Squalene/phytoene synthase K00801 - 2.5.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009792 420.0
TLS3_k127_6543651_18 PFAM binding-protein-dependent transport systems inner membrane component K02046,K15496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 417.0
TLS3_k127_6543651_19 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 402.0
TLS3_k127_6543651_2 Bacterial regulatory protein, Fis family K13599 - - 2.189e-235 734.0
TLS3_k127_6543651_20 sulfate ABC transporter K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 394.0
TLS3_k127_6543651_21 phosphate ion binding K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 340.0
TLS3_k127_6543651_22 spore germination - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 340.0
TLS3_k127_6543651_23 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 331.0
TLS3_k127_6543651_24 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 321.0
TLS3_k127_6543651_25 tungstate binding K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 309.0
TLS3_k127_6543651_26 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 304.0
TLS3_k127_6543651_27 response regulator, receiver K03413,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 295.0
TLS3_k127_6543651_29 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003354 273.0
TLS3_k127_6543651_3 ATPase associated with various cellular activities, AAA_5 K02584 - - 3.009e-219 697.0
TLS3_k127_6543651_32 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000001479 231.0
TLS3_k127_6543651_33 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000038 225.0
TLS3_k127_6543651_34 TupA-like ATPgrasp - - - 0.000000000000000000000000000000000000000000000000000000000000005907 228.0
TLS3_k127_6543651_35 TupA-like ATPgrasp - - - 0.00000000000000000000000000000000000000000000000000000000001154 218.0
TLS3_k127_6543651_36 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000001821 219.0
TLS3_k127_6543651_38 - - - - 0.00000000000000000000000000000000000000000000000000001127 190.0
TLS3_k127_6543651_39 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000000000000119 193.0
TLS3_k127_6543651_4 Response regulator, receiver K20973 - 2.7.13.3 1.321e-211 681.0
TLS3_k127_6543651_42 - - - - 0.000000000000000000000000000000000000000000000001901 178.0
TLS3_k127_6543651_43 Electron donor reductase for cytochrome b5. The cytochrome b5 NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity) K00326 GO:0000166,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004128,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005783,GO:0005886,GO:0006091,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0012505,GO:0016020,GO:0016070,GO:0016491,GO:0016651,GO:0016653,GO:0019867,GO:0022900,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0098588,GO:0098805,GO:1901265,GO:1901360,GO:1901363 1.6.2.2 0.00000000000000000000000000000000000000000000001699 180.0
TLS3_k127_6543651_44 Ferredoxin - - - 0.00000000000000000000000000000000000000000000004284 171.0
TLS3_k127_6543651_45 response regulator, receiver K03413,K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000004523 169.0
TLS3_k127_6543651_46 PBP superfamily domain K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000156 161.0
TLS3_k127_6543651_47 Cytochrome c - - - 0.000000000000000000000000000000000000000006655 158.0
TLS3_k127_6543651_49 ribonucleoside-diphosphate reductase activity K07735 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000001428 157.0
TLS3_k127_6543651_5 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 5.431e-206 651.0
TLS3_k127_6543651_50 Domain of unknown function (DUF1844) - - - 0.000000000000000000000000000000000000003811 152.0
TLS3_k127_6543651_51 - - - - 0.0000000000000000000000000000000000002352 144.0
TLS3_k127_6543651_52 Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000000000000000000000833 134.0
TLS3_k127_6543651_55 - - - - 0.000000000000000000000000001859 117.0
TLS3_k127_6543651_56 beta-lactamase activity K07126 - - 0.00000000000000000000000002094 116.0
TLS3_k127_6543651_57 Uncharacterized protein conserved in bacteria (DUF2325) - - - 0.0000000000000000000000001814 108.0
TLS3_k127_6543651_58 Regulatory protein, FmdB family - - - 0.00000000000000000000002867 102.0
TLS3_k127_6543651_6 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 603.0
TLS3_k127_6543651_60 PFAM Hpt domain protein - - - 0.000000000000000000008984 96.0
TLS3_k127_6543651_61 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000000006593 89.0
TLS3_k127_6543651_62 Small metal-binding protein - - - 0.0000000000000001747 85.0
TLS3_k127_6543651_63 Uncharacterized small protein (DUF2292) - - - 0.000000001596 60.0
TLS3_k127_6543651_65 Sel1-like repeats. K07126 - - 0.00000002615 65.0
TLS3_k127_6543651_66 - - - - 0.00003934 46.0
TLS3_k127_6543651_67 PFAM blue (type 1) copper domain protein - - - 0.00005401 46.0
TLS3_k127_6543651_7 alanine dehydrogenase activity K00259 GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009653,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030312,GO:0030435,GO:0032502,GO:0036293,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 548.0
TLS3_k127_6543651_8 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008226 533.0
TLS3_k127_6543651_9 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 516.0
TLS3_k127_6626436_0 silver ion transport K15726 - - 0.0 1215.0
TLS3_k127_6626436_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 445.0
TLS3_k127_6626436_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 287.0
TLS3_k127_6652475_0 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000009147 224.0
TLS3_k127_6652475_1 addiction module antidote protein - - - 0.00000000000000000000000000000000000000000006992 162.0
TLS3_k127_6652475_2 TIGRFAM Addiction module killer protein - - - 0.00000000000000000000000000000000007201 135.0
TLS3_k127_6652475_3 MafB19-like deaminase K01493 - 3.5.4.12 0.000000004553 60.0
TLS3_k127_6652475_4 Protein of unknown function (DUF2442) - - - 0.00003934 46.0
TLS3_k127_6817247_0 secondary active sulfate transmembrane transporter activity - - - 5.678e-264 824.0
TLS3_k127_6817247_1 Aldehyde dehydrogenase family - - - 1.109e-202 641.0
TLS3_k127_6817247_10 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 447.0
TLS3_k127_6817247_11 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 431.0
TLS3_k127_6817247_12 Protein of unknown function (DUF692) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 435.0
TLS3_k127_6817247_13 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 407.0
TLS3_k127_6817247_14 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 414.0
TLS3_k127_6817247_15 Belongs to the pseudouridine synthase RsuA family K06178,K06181,K06182 - 5.4.99.20,5.4.99.21,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008159 345.0
TLS3_k127_6817247_16 arginine decarboxylase activity K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 340.0
TLS3_k127_6817247_17 Bacterial regulatory helix-turn-helix protein, lysR family K03717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005564 334.0
TLS3_k127_6817247_18 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 323.0
TLS3_k127_6817247_19 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 291.0
TLS3_k127_6817247_2 protein secretion by the type I secretion system K02021 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 619.0
TLS3_k127_6817247_20 signal-transduction protein containing cAMP-binding and CBS domains K00031,K14446 - 1.1.1.42,1.3.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003167 277.0
TLS3_k127_6817247_21 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000008568 220.0
TLS3_k127_6817247_22 maF-like protein K03215,K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 2.1.1.190 0.00000000000000000000000000000000000000000000000009725 184.0
TLS3_k127_6817247_24 - - - - 0.0005528 49.0
TLS3_k127_6817247_3 peptidyl-lysine modification to peptidyl-hypusine K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 600.0
TLS3_k127_6817247_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 573.0
TLS3_k127_6817247_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 521.0
TLS3_k127_6817247_6 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 506.0
TLS3_k127_6817247_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 508.0
TLS3_k127_6817247_8 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05541 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 468.0
TLS3_k127_6817247_9 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 451.0
TLS3_k127_6870229_0 Sucrose-6F-phosphate phosphohydrolase - - - 4.797e-205 652.0
TLS3_k127_6870229_1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 430.0
TLS3_k127_6870229_10 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000004326 213.0
TLS3_k127_6870229_11 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000004987 174.0
TLS3_k127_6870229_12 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000001804 153.0
TLS3_k127_6870229_13 Protein conserved in bacteria - - - 0.000000000000000000000000000000000007187 149.0
TLS3_k127_6870229_14 PFAM DoxX K15977 - - 0.000000000000000000000000000000001754 135.0
TLS3_k127_6870229_15 Ferredoxin - - - 0.000000000000000000000000001431 116.0
TLS3_k127_6870229_16 phosphorelay signal transduction system - - - 0.000000000000000000000005913 108.0
TLS3_k127_6870229_17 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.00000000000000000000000596 113.0
TLS3_k127_6870229_18 - - - - 0.000000000000000000000246 103.0
TLS3_k127_6870229_19 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000005151 100.0
TLS3_k127_6870229_2 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 433.0
TLS3_k127_6870229_20 - - - - 0.000000000000000000009531 104.0
TLS3_k127_6870229_21 - - - - 0.00000000000000002294 89.0
TLS3_k127_6870229_23 PRC-barrel domain - - - 0.000000000001923 76.0
TLS3_k127_6870229_24 DNA ligase K01971 - 6.5.1.1 0.00000000000728 66.0
TLS3_k127_6870229_25 BON domain - - - 0.000000003915 64.0
TLS3_k127_6870229_27 YtxH-like protein - - - 0.0001353 49.0
TLS3_k127_6870229_3 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 432.0
TLS3_k127_6870229_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00615,K00616 - 2.2.1.1,2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 383.0
TLS3_k127_6870229_5 metallophosphoesterase K07096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 289.0
TLS3_k127_6870229_6 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000244 278.0
TLS3_k127_6870229_7 Nucleotidyl transferase of unknown function (DUF2204) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001917 265.0
TLS3_k127_6870229_8 Anabaena sensory rhodopsin transducer - - - 0.000000000000000000000000000000000000000000000000000000000002996 211.0
TLS3_k127_6870229_9 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000004124 214.0
TLS3_k127_6890812_0 DNA ligase K01971 - 6.5.1.1 1.432e-221 715.0
TLS3_k127_6890812_1 in signal transduction K08482 - - 1.023e-214 681.0
TLS3_k127_6890812_10 CrcB-like protein, Camphor Resistance (CrcB) K06199 - - 0.0000000000000000000000000000000000000000005865 160.0
TLS3_k127_6890812_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000008968 166.0
TLS3_k127_6890812_12 KaiB domain K08481 - - 0.0000000000000000000000000000000000003844 144.0
TLS3_k127_6890812_13 UPF0060 membrane protein K09771 - - 0.000000000000000000000000000000000001635 140.0
TLS3_k127_6890812_14 Cytochrome c K00406,K20200 - - 0.00000000000000000000000000000000354 131.0
TLS3_k127_6890812_15 integral membrane protein - - - 0.000000000000000000000000000000005181 133.0
TLS3_k127_6890812_16 KaiB K08481 - - 0.00000000000000000000000000000003388 128.0
TLS3_k127_6890812_17 phosphorelay signal transduction system K02535 - 3.5.1.108 0.0000000000000000000000000000000531 128.0
TLS3_k127_6890812_19 Membrane protease subunits, stomatin prohibitin homologs - - - 0.000000000000000000000000001134 122.0
TLS3_k127_6890812_2 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 601.0
TLS3_k127_6890812_20 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000005564 121.0
TLS3_k127_6890812_21 Thiamine-binding protein - - - 0.0000000000000000000001802 105.0
TLS3_k127_6890812_22 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000002603 78.0
TLS3_k127_6890812_23 Response regulator receiver - - - 0.000000000001494 70.0
TLS3_k127_6890812_24 Uncharacterized protein conserved in bacteria (DUF2188) - - - 0.000006057 49.0
TLS3_k127_6890812_25 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00001094 48.0
TLS3_k127_6890812_26 - - - - 0.0001742 47.0
TLS3_k127_6890812_3 Histidine kinase K07711,K19694 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 464.0
TLS3_k127_6890812_4 Nucleotidyltransferase DNA polymerase involved in DNA repair K03502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008892 418.0
TLS3_k127_6890812_5 PFAM Formylglycine-generating sulfatase enzyme K20333 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 348.0
TLS3_k127_6890812_6 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 325.0
TLS3_k127_6890812_7 response regulator - - - 0.000000000000000000000000000000000000000000000000000000001139 220.0
TLS3_k127_6890812_8 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000001037 216.0
TLS3_k127_6890812_9 Peptidase S24-like K03503 - - 0.000000000000000000000000000000000000000000008483 166.0
TLS3_k127_6904692_0 PFAM FAD dependent oxidoreductase - - - 2.976e-200 636.0
TLS3_k127_6904692_1 Protein of unknown function (DUF1207) - - - 0.00000000000000000000000000000000006576 141.0
TLS3_k127_6904692_2 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000002228 132.0
TLS3_k127_6904692_3 UPF0391 membrane protein - - - 0.000000000000002081 78.0
TLS3_k127_6964567_0 Peptidase family M1 domain K08776 - - 0.0 1051.0
TLS3_k127_6964567_1 FtsX-like permease family K02004 - - 0.0 1041.0
TLS3_k127_6964567_10 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K00851,K00852,K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 310.0
TLS3_k127_6964567_11 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 312.0
TLS3_k127_6964567_12 lipolytic protein G-D-S-L family K10804 GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003442 273.0
TLS3_k127_6964567_13 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000001663 241.0
TLS3_k127_6964567_14 zinc ion binding - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000001335 228.0
TLS3_k127_6964567_15 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000005923 154.0
TLS3_k127_6964567_17 - - - - 0.00000000001071 73.0
TLS3_k127_6964567_19 DDE superfamily endonuclease - - - 0.000003138 50.0
TLS3_k127_6964567_2 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 6.334e-223 704.0
TLS3_k127_6964567_3 Transglutaminase/protease-like homologues - - - 8.906e-195 631.0
TLS3_k127_6964567_4 Glucokinase K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 521.0
TLS3_k127_6964567_5 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 506.0
TLS3_k127_6964567_7 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007938 376.0
TLS3_k127_6964567_8 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009775 344.0
TLS3_k127_6964567_9 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 312.0
TLS3_k127_6999892_0 anaerobic respiration K10535 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114 1.7.2.6 1.815e-263 822.0
TLS3_k127_6999892_1 TonB-dependent receptor K02014 - - 1.119e-198 637.0
TLS3_k127_6999892_2 COG1538 Outer membrane protein K12340 - - 0.000000002466 61.0
TLS3_k127_6999892_3 COG1538 Outer membrane protein K12340 GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351 - 0.00000001583 59.0
TLS3_k127_7043738_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1384.0
TLS3_k127_7043738_1 hydrogen-translocating pyrophosphatase activity K15987 - 3.6.1.1 0.0 1187.0
TLS3_k127_7043738_10 efflux transmembrane transporter activity K12340 - - 1.177e-230 725.0
TLS3_k127_7043738_11 denitrification pathway - - - 1.487e-220 692.0
TLS3_k127_7043738_12 tail specific protease K03797 - 3.4.21.102 5.894e-213 670.0
TLS3_k127_7043738_13 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005463 534.0
TLS3_k127_7043738_14 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 530.0
TLS3_k127_7043738_15 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 511.0
TLS3_k127_7043738_16 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 482.0
TLS3_k127_7043738_17 thiosulfate sulfurtransferase activity K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 469.0
TLS3_k127_7043738_18 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 469.0
TLS3_k127_7043738_19 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 418.0
TLS3_k127_7043738_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0 1169.0
TLS3_k127_7043738_20 Protein of unknown function (DUF3422) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 426.0
TLS3_k127_7043738_21 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009625 410.0
TLS3_k127_7043738_22 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 392.0
TLS3_k127_7043738_23 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 368.0
TLS3_k127_7043738_24 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 339.0
TLS3_k127_7043738_25 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 343.0
TLS3_k127_7043738_26 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 339.0
TLS3_k127_7043738_27 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K03432 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008345 336.0
TLS3_k127_7043738_28 ribonucleoside-diphosphate reductase activity K07735 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 297.0
TLS3_k127_7043738_29 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000008159 267.0
TLS3_k127_7043738_3 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1122.0
TLS3_k127_7043738_31 NADPH-dependent FMN reductase K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000007704 249.0
TLS3_k127_7043738_32 conserved protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001015 231.0
TLS3_k127_7043738_34 CMP dCMP deaminase, zinc-binding - - - 0.0000000000000000000000000000000000000000000000000000000000775 210.0
TLS3_k127_7043738_35 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000007657 201.0
TLS3_k127_7043738_36 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000000000000000000003001 200.0
TLS3_k127_7043738_37 DNA-directed DNA polymerase activity K02347,K03581,K04477 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000001491 189.0
TLS3_k127_7043738_38 ribosome binding K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000005497 177.0
TLS3_k127_7043738_39 HemY protein K02498 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000001617 172.0
TLS3_k127_7043738_4 protein catabolic process K13527 GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - 0.0 1020.0
TLS3_k127_7043738_40 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000000000000000002654 160.0
TLS3_k127_7043738_41 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000000000000001036 161.0
TLS3_k127_7043738_42 RNA recognition motif - - - 0.000000000000000000000000000000000000000002166 159.0
TLS3_k127_7043738_43 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000002626 156.0
TLS3_k127_7043738_44 - - - - 0.000000000000000000000000000000000000000002669 160.0
TLS3_k127_7043738_46 Uncharacterised protein family UPF0102 K07460 - - 0.000000000000000000000000000000000012 139.0
TLS3_k127_7043738_48 - K14588 - - 0.000000000000000000000000000001695 127.0
TLS3_k127_7043738_49 Domain of unknown function (DUF4321) - - - 0.00000000000000000000000000005026 124.0
TLS3_k127_7043738_5 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 1.77e-282 871.0
TLS3_k127_7043738_54 ThiS family K03154 - - 0.000000000000000009116 85.0
TLS3_k127_7043738_55 2 iron, 2 sulfur cluster binding K02192 GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - 0.0000000000000002711 79.0
TLS3_k127_7043738_56 PFAM Sulphatase-modifying factor - - - 0.000000000002058 74.0
TLS3_k127_7043738_57 Small metal-binding protein - - - 0.00000000001913 69.0
TLS3_k127_7043738_58 Putative bacterial lipoprotein (DUF799) - - - 0.000000000104 69.0
TLS3_k127_7043738_59 Domain of unknown function (DUF4810) - - - 0.000000001145 64.0
TLS3_k127_7043738_6 metalloendopeptidase activity K08602 - - 5.265e-265 828.0
TLS3_k127_7043738_60 Protein of unknown function DUF86 - - - 0.000000001292 61.0
TLS3_k127_7043738_61 Monoamine oxidase K00274 - 1.4.3.4 0.00000009685 55.0
TLS3_k127_7043738_62 PFAM DNA polymerase beta domain protein region - - - 0.00001476 48.0
TLS3_k127_7043738_63 Protein of unknown function DUF86 - - - 0.00007494 46.0
TLS3_k127_7043738_64 Protein of unknown function DUF86 - - - 0.0001134 46.0
TLS3_k127_7043738_65 nucleotidyltransferase activity K07076 - - 0.0003354 48.0
TLS3_k127_7043738_7 O-methyltransferase activity K13571,K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 1.629e-244 766.0
TLS3_k127_7043738_8 DHH family K07462 - - 1.96e-237 748.0
TLS3_k127_7043738_9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 6.784e-231 720.0
TLS3_k127_7138155_0 siderophore transport K02014 - - 0.0 1030.0
TLS3_k127_7138155_1 cobalamin synthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 409.0
TLS3_k127_7138155_10 translation initiation factor activity K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00005941 48.0
TLS3_k127_7138155_11 PFAM transposase IS4 family protein - - - 0.0004003 48.0
TLS3_k127_7138155_2 PFAM Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000303 253.0
TLS3_k127_7138155_4 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000001035 201.0
TLS3_k127_7138155_5 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000001526 196.0
TLS3_k127_7138155_6 Transposase - - - 0.000000000002069 66.0
TLS3_k127_7138155_7 PFAM transposase IS4 family protein - - - 0.000000101 54.0
TLS3_k127_7138155_8 manually curated - - - 0.0000005713 53.0
TLS3_k127_7138155_9 PFAM Insertion element protein K07488 - - 0.0000007482 53.0
TLS3_k127_7156232_0 nitrite reductase [NAD(P)H] activity K00158,K00363,K03809,K05710 - 1.2.3.3,1.6.5.2,1.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 289.0
TLS3_k127_7156232_1 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000228 253.0
TLS3_k127_72867_0 metallopeptidase activity K03568 - - 1.785e-261 811.0
TLS3_k127_72867_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 586.0
TLS3_k127_72867_10 Putative addiction module component - - - 0.000000000000000000000000004941 116.0
TLS3_k127_72867_11 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000004345 85.0
TLS3_k127_72867_12 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0005807 50.0
TLS3_k127_72867_2 Predicted nucleotide-binding protein containing TIR-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 367.0
TLS3_k127_72867_3 peptide-methionine (S)-S-oxide reductase activity K07304,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 286.0
TLS3_k127_72867_4 Peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000085 250.0
TLS3_k127_72867_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000003356 235.0
TLS3_k127_72867_6 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000006577 220.0
TLS3_k127_72867_7 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000000000000000000000000000000004208 170.0
TLS3_k127_72867_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000006379 181.0
TLS3_k127_72867_9 Cupin domain - - - 0.0000000000000000000000000000000000000004138 153.0
TLS3_k127_7301980_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 1.792e-285 888.0
TLS3_k127_7301980_1 cytochrome p450 - - - 8.315e-243 756.0
TLS3_k127_7301980_10 PSP1 C-terminal conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 301.0
TLS3_k127_7301980_11 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 301.0
TLS3_k127_7301980_12 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000292 273.0
TLS3_k127_7301980_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003652 267.0
TLS3_k127_7301980_14 metal cluster binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008061 268.0
TLS3_k127_7301980_15 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000004933 235.0
TLS3_k127_7301980_16 Ubiquinol--cytochrome c reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005382 232.0
TLS3_k127_7301980_17 Belongs to the ParB family K03497 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000002643 224.0
TLS3_k127_7301980_18 metal cluster binding K06940 - - 0.00000000000000000000000000000000000000000000000000000007721 201.0
TLS3_k127_7301980_19 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000001018 188.0
TLS3_k127_7301980_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.946e-213 676.0
TLS3_k127_7301980_21 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000001738 183.0
TLS3_k127_7301980_22 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000001644 176.0
TLS3_k127_7301980_24 regulation of translation K03530 - - 0.0000000000000000000000000000000000000000001991 161.0
TLS3_k127_7301980_26 Zn peptidase - - - 0.0000000000000000000000000000000000000001574 151.0
TLS3_k127_7301980_27 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000001101 152.0
TLS3_k127_7301980_28 protein secretion K03116,K03117 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000003383 137.0
TLS3_k127_7301980_29 Mo-molybdopterin cofactor metabolic process K03636 - - 0.0000000000000000000000000000000003921 132.0
TLS3_k127_7301980_3 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 6.442e-211 670.0
TLS3_k127_7301980_30 dUTPase K01494 - 3.5.4.13 0.00000000000000000000000000000004044 132.0
TLS3_k127_7301980_31 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000003076 106.0
TLS3_k127_7301980_32 ribonuclease P activity K03536,K08998 GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000001078 102.0
TLS3_k127_7301980_33 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000000002434 104.0
TLS3_k127_7301980_34 Belongs to the bacterial ribosomal protein bL34 family K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000004577 64.0
TLS3_k127_7301980_4 glucose sorbosone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000798 491.0
TLS3_k127_7301980_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 480.0
TLS3_k127_7301980_6 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 447.0
TLS3_k127_7301980_7 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006752 368.0
TLS3_k127_7301980_8 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 356.0
TLS3_k127_7301980_9 Phosphoserine phosphatase K02203 - 2.7.1.39,3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 321.0
TLS3_k127_7333634_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 3.474e-251 780.0
TLS3_k127_7333634_1 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 1.443e-227 714.0
TLS3_k127_7333634_10 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 342.0
TLS3_k127_7333634_11 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 328.0
TLS3_k127_7333634_12 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 282.0
TLS3_k127_7333634_13 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 282.0
TLS3_k127_7333634_14 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002457 279.0
TLS3_k127_7333634_15 Ribosomal protein L4/L1 family K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005938 278.0
TLS3_k127_7333634_16 Pilus assembly protein, PilO K02664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004221 267.0
TLS3_k127_7333634_17 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003679 253.0
TLS3_k127_7333634_18 Fimbrial assembly protein (PilN) K02663 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003515 251.0
TLS3_k127_7333634_19 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008992 241.0
TLS3_k127_7333634_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 554.0
TLS3_k127_7333634_20 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000001542 237.0
TLS3_k127_7333634_21 Protein conserved in bacteria K11719 - - 0.00000000000000000000000000000000000000000000000000000000000000000006537 237.0
TLS3_k127_7333634_22 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000006526 216.0
TLS3_k127_7333634_23 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000003887 207.0
TLS3_k127_7333634_24 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001811 200.0
TLS3_k127_7333634_25 Pilus assembly protein, PilP K02665 - - 0.0000000000000000000000000000000000000000000000000000006981 199.0
TLS3_k127_7333634_26 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001637 191.0
TLS3_k127_7333634_27 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000004423 190.0
TLS3_k127_7333634_28 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000398 178.0
TLS3_k127_7333634_29 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000006142 174.0
TLS3_k127_7333634_3 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 509.0
TLS3_k127_7333634_30 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000804 173.0
TLS3_k127_7333634_31 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000000000000002047 163.0
TLS3_k127_7333634_32 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000007155 153.0
TLS3_k127_7333634_33 OstA-like protein K09774 - - 0.0000000000000000000000000000000000002526 148.0
TLS3_k127_7333634_34 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000005334 135.0
TLS3_k127_7333634_35 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.00000000000000000000000000000000005888 134.0
TLS3_k127_7333634_36 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000000000000000000002558 132.0
TLS3_k127_7333634_37 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.00000000000000000000000000001839 122.0
TLS3_k127_7333634_38 30S ribosomal protein S14 K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000003801 113.0
TLS3_k127_7333634_39 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K11686,K13640,K18997 - - 0.000000000000000006878 85.0
TLS3_k127_7333634_4 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 475.0
TLS3_k127_7333634_40 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000009004 81.0
TLS3_k127_7333634_41 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000002486 81.0
TLS3_k127_7333634_42 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000006563 77.0
TLS3_k127_7333634_43 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000846 68.0
TLS3_k127_7333634_44 Secretin and TonB N terminus short domain K02666 - - 0.00000000003963 70.0
TLS3_k127_7333634_45 transposition K07497 - - 0.000000004244 64.0
TLS3_k127_7333634_46 transposase activity K07483,K07497 - - 0.0000004698 52.0
TLS3_k127_7333634_47 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.00001872 47.0
TLS3_k127_7333634_48 transposition K07497 - - 0.0001199 44.0
TLS3_k127_7333634_5 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 435.0
TLS3_k127_7333634_6 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 409.0
TLS3_k127_7333634_7 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 396.0
TLS3_k127_7333634_8 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 392.0
TLS3_k127_7333634_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 344.0
TLS3_k127_7372642_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1005.0
TLS3_k127_7372642_1 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 4.345e-286 893.0
TLS3_k127_7372642_10 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000001415 121.0
TLS3_k127_7372642_11 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.0000000000000000000008239 104.0
TLS3_k127_7372642_12 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00371,K16965,K17048,K17051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 0.0000000000000000002452 87.0
TLS3_k127_7372642_2 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 1.611e-274 852.0
TLS3_k127_7372642_3 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007794 447.0
TLS3_k127_7372642_4 Alpha-amylase domain K05341,K05343 - 2.4.1.4,3.2.1.1,5.4.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006593 386.0
TLS3_k127_7372642_5 Glycosyl transferase family 2 K21349 - 2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 381.0
TLS3_k127_7372642_6 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 289.0
TLS3_k127_7372642_7 transmembrane transport - - - 0.00000000000000000000000000000000000000000000000000000000000001042 223.0
TLS3_k127_7372642_8 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.0000000000000000000000000000000000001268 143.0
TLS3_k127_7372642_9 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.00000000000000000000000000000001673 140.0
TLS3_k127_7381159_0 Molydopterin dinucleotide binding domain K00302,K10814 - 1.4.99.5,1.5.3.1 0.0 1450.0
TLS3_k127_7381159_1 NADH-quinone oxidoreductase K00341,K05568,K12139 - 1.6.5.3 0.0 1029.0
TLS3_k127_7381159_10 CHASE3 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 546.0
TLS3_k127_7381159_11 Evidence 4 Homologs of previously reported genes of K18912 - 1.14.99.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 520.0
TLS3_k127_7381159_12 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 505.0
TLS3_k127_7381159_13 Evidence 4 Homologs of previously reported genes of K18912 - 1.14.99.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 501.0
TLS3_k127_7381159_14 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 496.0
TLS3_k127_7381159_15 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255,K01259 GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 473.0
TLS3_k127_7381159_16 cobalamin binding K21089,K21972,K22491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 447.0
TLS3_k127_7381159_17 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 407.0
TLS3_k127_7381159_18 Flagellar Motor Protein K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 406.0
TLS3_k127_7381159_19 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 409.0
TLS3_k127_7381159_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342,K05575 - 1.6.5.3 1.501e-294 912.0
TLS3_k127_7381159_20 coenzyme binding K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 385.0
TLS3_k127_7381159_21 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 355.0
TLS3_k127_7381159_22 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 358.0
TLS3_k127_7381159_23 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 335.0
TLS3_k127_7381159_24 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007109 326.0
TLS3_k127_7381159_25 Phosphoserine phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 301.0
TLS3_k127_7381159_26 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 328.0
TLS3_k127_7381159_27 Phosphodiester glycosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 299.0
TLS3_k127_7381159_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001925 276.0
TLS3_k127_7381159_29 sirohydrochlorin cobaltochelatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005759 275.0
TLS3_k127_7381159_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 1.646e-263 813.0
TLS3_k127_7381159_30 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005623 287.0
TLS3_k127_7381159_31 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004726 256.0
TLS3_k127_7381159_32 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000004056 256.0
TLS3_k127_7381159_33 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000001174 239.0
TLS3_k127_7381159_34 NADH dehydrogenase (ubiquinone) activity K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000001851 224.0
TLS3_k127_7381159_35 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000008125 203.0
TLS3_k127_7381159_37 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000001462 178.0
TLS3_k127_7381159_38 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000001972 172.0
TLS3_k127_7381159_39 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000000000000008079 165.0
TLS3_k127_7381159_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 6.649e-262 814.0
TLS3_k127_7381159_44 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.0000000000004818 70.0
TLS3_k127_7381159_46 Small metal-binding protein - - - 0.0000000001067 67.0
TLS3_k127_7381159_47 Protein of unknown function (DUF1566) - - - 0.00000009461 61.0
TLS3_k127_7381159_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 1.209e-253 789.0
TLS3_k127_7381159_6 Amino acid permease K03294 - - 4.613e-234 732.0
TLS3_k127_7381159_7 Belongs to the DNA photolyase family K01669 - 4.1.99.3 5.163e-227 711.0
TLS3_k127_7381159_8 Evidence 4 Homologs of previously reported genes of K18912 - 1.14.99.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 568.0
TLS3_k127_7381159_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 556.0
TLS3_k127_7387758_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1359.0
TLS3_k127_7387758_1 Surface antigen K07277 - - 0.0 1080.0
TLS3_k127_7387758_10 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 467.0
TLS3_k127_7387758_11 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 441.0
TLS3_k127_7387758_12 Protein of unknown function (DUF1009) K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 415.0
TLS3_k127_7387758_13 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 413.0
TLS3_k127_7387758_14 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 394.0
TLS3_k127_7387758_15 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 392.0
TLS3_k127_7387758_16 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 353.0
TLS3_k127_7387758_17 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 344.0
TLS3_k127_7387758_18 Nucleotidyl transferase K15669 - 2.7.7.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 316.0
TLS3_k127_7387758_19 ABC transporter K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 307.0
TLS3_k127_7387758_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K06147,K11085 - - 8.352e-266 829.0
TLS3_k127_7387758_20 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002229 278.0
TLS3_k127_7387758_21 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000369 258.0
TLS3_k127_7387758_22 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000002376 235.0
TLS3_k127_7387758_23 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000005979 233.0
TLS3_k127_7387758_24 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor - - - 0.000000000000000000000000000000000000000000000000000000000000003515 221.0
TLS3_k127_7387758_25 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000001889 225.0
TLS3_k127_7387758_26 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000000000000000000000000000001078 216.0
TLS3_k127_7387758_27 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.00000000000000000000000000000000000000000000000000000000001371 211.0
TLS3_k127_7387758_28 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000000000000000000000003944 209.0
TLS3_k127_7387758_29 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000004517 196.0
TLS3_k127_7387758_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 6.259e-261 809.0
TLS3_k127_7387758_30 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.000000000000000000000000000000000000000000000003944 178.0
TLS3_k127_7387758_31 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000102 181.0
TLS3_k127_7387758_32 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000001231 174.0
TLS3_k127_7387758_33 Transcription termination factor nusG - - - 0.00000000000000000000000000000000000000000004763 165.0
TLS3_k127_7387758_34 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.000000000000000000000000000000000000000000178 163.0
TLS3_k127_7387758_35 Winged helix-turn-helix DNA-binding - - - 0.0000000000000000000000000000000000005904 147.0
TLS3_k127_7387758_36 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000001617 121.0
TLS3_k127_7387758_37 polysaccharide biosynthetic process - - - 0.000000000000000001616 100.0
TLS3_k127_7387758_4 B12 binding domain - - - 5.494e-240 751.0
TLS3_k127_7387758_5 Belongs to the DegT DnrJ EryC1 family - - - 5.095e-211 659.0
TLS3_k127_7387758_6 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 1.312e-208 663.0
TLS3_k127_7387758_7 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 527.0
TLS3_k127_7387758_8 Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 482.0
TLS3_k127_7387758_9 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 477.0
TLS3_k127_7414187_0 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 564.0
TLS3_k127_7414187_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 479.0
TLS3_k127_7414187_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000704 394.0
TLS3_k127_7414187_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 377.0
TLS3_k127_7414187_4 - - - - 0.00000000000000000000001832 100.0
TLS3_k127_7772015_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1423.0
TLS3_k127_7772015_1 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0 1155.0
TLS3_k127_7772015_10 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 521.0
TLS3_k127_7772015_11 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 520.0
TLS3_k127_7772015_12 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 477.0
TLS3_k127_7772015_13 rRNA (guanine-N2-)-methyltransferase activity K09846,K13604,K21460 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.210,2.1.1.304,2.1.1.333 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 467.0
TLS3_k127_7772015_14 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 439.0
TLS3_k127_7772015_15 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 425.0
TLS3_k127_7772015_16 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007855 420.0
TLS3_k127_7772015_17 Evidence 4 Homologs of previously reported genes of K18912 - 1.14.99.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 409.0
TLS3_k127_7772015_18 membrane K08976 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 375.0
TLS3_k127_7772015_2 Cytochrome c K00405 - - 6.054e-317 979.0
TLS3_k127_7772015_20 peroxiredoxin activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007731 302.0
TLS3_k127_7772015_22 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001116 259.0
TLS3_k127_7772015_25 TIGRFAM Urease, alpha gamma subunit K01430 - 3.5.1.5 0.0000000000000000000000000000000000000000002284 162.0
TLS3_k127_7772015_26 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000001145 163.0
TLS3_k127_7772015_27 Preprotein translocase subunit K03210 - - 0.000000000000000000000000000000000000007633 147.0
TLS3_k127_7772015_28 Belongs to the urease beta subunit family K01429 - 3.5.1.5 0.0000000000000000000000000000000000001164 147.0
TLS3_k127_7772015_3 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 3.077e-290 900.0
TLS3_k127_7772015_30 Protein of unknown function (DUF541) K09807 - - 0.000000313 56.0
TLS3_k127_7772015_32 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0003267 46.0
TLS3_k127_7772015_4 aerobic electron transport chain K00425,K08738 - 1.10.3.14 1.95e-286 892.0
TLS3_k127_7772015_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 1.394e-260 812.0
TLS3_k127_7772015_6 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 4.87e-251 786.0
TLS3_k127_7772015_7 Cytochrome c K00405 - - 1.858e-208 655.0
TLS3_k127_7772015_8 phosphorelay signal transduction system - - - 2.521e-202 642.0
TLS3_k127_7772015_9 Cytochrome c - - - 6.748e-199 622.0
TLS3_k127_7798519_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1130.0
TLS3_k127_7798519_1 pyruvate decarboxylase activity K04103 - 4.1.1.74 8.716e-268 833.0
TLS3_k127_7798519_10 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 492.0
TLS3_k127_7798519_11 protoporphyrinogen oxidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 492.0
TLS3_k127_7798519_12 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 430.0
TLS3_k127_7798519_13 LPP20 lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 419.0
TLS3_k127_7798519_14 Peptidoglycan-synthase activator LpoB K07337 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 315.0
TLS3_k127_7798519_15 Lumazine binding domain K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 316.0
TLS3_k127_7798519_16 mannosylglycerate metabolic process K05947,K07026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 2.4.1.217,3.1.3.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 293.0
TLS3_k127_7798519_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001331 282.0
TLS3_k127_7798519_18 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008805 244.0
TLS3_k127_7798519_19 Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide K01725 - 4.2.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000403 236.0
TLS3_k127_7798519_2 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 1.614e-217 680.0
TLS3_k127_7798519_21 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000005227 222.0
TLS3_k127_7798519_22 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000000000000004449 138.0
TLS3_k127_7798519_23 Helix-turn-helix XRE-family like proteins K21498 - - 0.000000000000000000000000000000637 124.0
TLS3_k127_7798519_24 Belongs to the UPF0149 family - - - 0.000000000000000000004146 102.0
TLS3_k127_7798519_25 Conserved TM helix - - - 0.00000000000000000007091 98.0
TLS3_k127_7798519_27 Lumazine binding domain K00793 - 2.5.1.9 0.0000000000001275 76.0
TLS3_k127_7798519_3 Glycosyl transferase, family 2 K21349 - 2.4.1.268 1.787e-196 624.0
TLS3_k127_7798519_4 MFS_1 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 602.0
TLS3_k127_7798519_5 protein conserved in bacteria K09859 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007699 541.0
TLS3_k127_7798519_6 phospholipase Carboxylesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 524.0
TLS3_k127_7798519_7 B-1 B cell differentiation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 514.0
TLS3_k127_7798519_8 conserved protein (DUF2081) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 505.0
TLS3_k127_7798519_9 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 496.0
TLS3_k127_7800383_0 Phosphate acyltransferases K01897 - 6.2.1.3 1.322e-244 784.0
TLS3_k127_7800383_1 Major facilitator superfamily K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009302 527.0
TLS3_k127_7800383_10 Na H antiporter K05571 - - 0.000000000000009548 79.0
TLS3_k127_7800383_11 NADH-ubiquinone oxidoreductase chain 4l K05567 - - 0.00000000000006306 76.0
TLS3_k127_7800383_12 Na+/H+ ion antiporter subunit K05562 - - 0.000000001628 68.0
TLS3_k127_7800383_13 Lipid A 3-O-deacylase (PagL) - - - 0.000000005254 61.0
TLS3_k127_7800383_14 Subunit F of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05570 - - 0.000000009245 61.0
TLS3_k127_7800383_15 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.00000004834 61.0
TLS3_k127_7800383_16 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000005669 59.0
TLS3_k127_7800383_17 Protein of unknown function (DUF2459) - - - 0.00000006093 64.0
TLS3_k127_7800383_18 - - - - 0.000003844 56.0
TLS3_k127_7800383_2 Protein involved in outer membrane biogenesis K07290 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 536.0
TLS3_k127_7800383_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006862 365.0
TLS3_k127_7800383_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 333.0
TLS3_k127_7800383_5 Na H antiporter K05565 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 327.0
TLS3_k127_7800383_6 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001972 275.0
TLS3_k127_7800383_7 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000002629 201.0
TLS3_k127_7800383_8 esterase - - - 0.00000000000000000000000000000000000000000006588 170.0
TLS3_k127_7800383_9 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.000000000000000000000001344 116.0
TLS3_k127_7859896_0 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004878 466.0
TLS3_k127_7859896_1 Protein of unknown function (DUF1264) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003176 332.0
TLS3_k127_7859896_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000001187 74.0
TLS3_k127_7859896_2 response regulator K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000001854 226.0
TLS3_k127_7859896_4 Histidine kinase K07683 - 2.7.13.3 0.000000000000000000000000000000000000000000002536 174.0
TLS3_k127_7859896_5 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000006826 136.0
TLS3_k127_7859896_6 - - - - 0.00000000000000000000000000005868 129.0
TLS3_k127_7859896_9 - - - - 0.0000000000000000000009955 103.0
TLS3_k127_7895648_0 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 503.0
TLS3_k127_7895648_1 translation release factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 311.0
TLS3_k127_7895648_2 transmembrane signaling receptor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004411 271.0
TLS3_k127_7895648_3 Intracellular protease K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000000001004 262.0
TLS3_k127_7895648_4 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000009766 237.0
TLS3_k127_7895648_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002468 228.0
TLS3_k127_7895648_6 - - - - 0.000000000000000000000000000000000000000000009152 167.0
TLS3_k127_7895648_7 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000009382 163.0
TLS3_k127_7895648_8 UPF0391 membrane protein - - - 0.000000653 53.0
TLS3_k127_7940540_0 Sterile alpha motif. - - - 0.0 1429.0
TLS3_k127_7940540_1 ABC1 family K03688 - - 0.0 1016.0
TLS3_k127_7940540_10 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 523.0
TLS3_k127_7940540_11 TIGRFAM argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 524.0
TLS3_k127_7940540_12 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005874 499.0
TLS3_k127_7940540_13 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 492.0
TLS3_k127_7940540_14 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 487.0
TLS3_k127_7940540_15 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 471.0
TLS3_k127_7940540_16 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 471.0
TLS3_k127_7940540_17 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 464.0
TLS3_k127_7940540_18 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 451.0
TLS3_k127_7940540_19 pseudouridine synthase activity K06176 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 453.0
TLS3_k127_7940540_2 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 3.64e-283 895.0
TLS3_k127_7940540_20 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 455.0
TLS3_k127_7940540_21 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 445.0
TLS3_k127_7940540_22 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 447.0
TLS3_k127_7940540_23 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 441.0
TLS3_k127_7940540_24 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 451.0
TLS3_k127_7940540_25 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 439.0
TLS3_k127_7940540_26 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 436.0
TLS3_k127_7940540_27 AAA domain, putative AbiEii toxin, Type IV TA system K09817,K09820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 430.0
TLS3_k127_7940540_28 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 437.0
TLS3_k127_7940540_29 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007281 426.0
TLS3_k127_7940540_3 Aminotransferase class I and II K10206 - 2.6.1.83 9.678e-239 740.0
TLS3_k127_7940540_30 dimethylargininase activity K00819 GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813 2.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008755 423.0
TLS3_k127_7940540_31 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007213 412.0
TLS3_k127_7940540_32 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 397.0
TLS3_k127_7940540_33 pectinesterase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 382.0
TLS3_k127_7940540_34 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 377.0
TLS3_k127_7940540_35 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 372.0
TLS3_k127_7940540_36 tRNA 3'-trailer cleavage - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 366.0
TLS3_k127_7940540_37 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 368.0
TLS3_k127_7940540_38 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 351.0
TLS3_k127_7940540_39 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 349.0
TLS3_k127_7940540_4 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 1.097e-220 688.0
TLS3_k127_7940540_40 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 344.0
TLS3_k127_7940540_41 Zinc-uptake complex component A periplasmic K09815,K09818 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 348.0
TLS3_k127_7940540_42 methyltransferase K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 329.0
TLS3_k127_7940540_43 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 327.0
TLS3_k127_7940540_44 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 284.0
TLS3_k127_7940540_46 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002278 276.0
TLS3_k127_7940540_47 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000004261 253.0
TLS3_k127_7940540_48 deoxyhypusine monooxygenase activity K02632 - 4.4.1.31 0.000000000000000000000000000000000000000000000000000000000000000000004429 240.0
TLS3_k127_7940540_49 domain protein K02004,K06994 - - 0.000000000000000000000000000000000000000000000000000000000000000000007135 250.0
TLS3_k127_7940540_5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 1.747e-207 653.0
TLS3_k127_7940540_50 cell adhesion K02650 - - 0.000000000000000000000000000000000000000000000000000000000000003733 226.0
TLS3_k127_7940540_52 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001885 199.0
TLS3_k127_7940540_54 chlorophyll binding K02487,K12543 - - 0.0000000000000000000000000000000000000000000000000001972 192.0
TLS3_k127_7940540_55 protein trimerization - - - 0.000000000000000000000000000000000000000000000000000975 188.0
TLS3_k127_7940540_56 Protein conserved in bacteria K16785 - - 0.00000000000000000000000000000000000000000000000463 177.0
TLS3_k127_7940540_58 Cytotoxic translational repressor of toxin-antitoxin stability system - - - 0.000000000000000000000000000000000000000006782 155.0
TLS3_k127_7940540_59 glutamine amidotransferase K01951 - 6.3.5.2 0.00000000000000000000000000000000000000005815 162.0
TLS3_k127_7940540_6 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 608.0
TLS3_k127_7940540_60 sequence-specific DNA binding K07726 - - 0.0000000000000000000000000000000000000001937 151.0
TLS3_k127_7940540_67 peptidase K02557,K21471 - - 0.0000000000000000000000000000000001112 149.0
TLS3_k127_7940540_7 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 602.0
TLS3_k127_7940540_70 Protein conserved in bacteria K20274 - - 0.000000000000000000000000000001081 136.0
TLS3_k127_7940540_71 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000000000000000000007953 123.0
TLS3_k127_7940540_74 - K07275 - - 0.0000000000000000000000003195 113.0
TLS3_k127_7940540_75 copG family - - - 0.0000000000000000000000007629 106.0
TLS3_k127_7940540_77 HicA toxin of bacterial toxin-antitoxin, K07339 - - 0.000000000000000000002201 94.0
TLS3_k127_7940540_78 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.00000000000000000000653 94.0
TLS3_k127_7940540_79 - - - - 0.0000000000000002638 91.0
TLS3_k127_7940540_8 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009793 544.0
TLS3_k127_7940540_81 monooxygenase activity K00688,K15760,K16157,K16242,K18223,K22353,K22357 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494 1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1 0.0000000004093 63.0
TLS3_k127_7940540_83 - - - - 0.000000006944 59.0
TLS3_k127_7940540_84 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000001685 65.0
TLS3_k127_7940540_85 protein conserved in bacteria - - - 0.0000009366 52.0
TLS3_k127_7940540_86 - - - - 0.0007437 51.0
TLS3_k127_7940540_9 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 526.0
TLS3_k127_7975488_0 Dehydratase family K01687 - 4.2.1.9 3.919e-314 968.0
TLS3_k127_7975488_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 346.0
TLS3_k127_7975488_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000009199 229.0
TLS3_k127_7975488_3 ATP-independent chaperone mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000000000005067 216.0
TLS3_k127_7975488_4 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000001392 189.0
TLS3_k127_7975488_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K05516 - - 0.000000005712 57.0
TLS3_k127_7975488_6 Prokaryotic N-terminal methylation motif K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.00000004345 61.0
TLS3_k127_8032814_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.791e-267 825.0
TLS3_k127_8032814_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 4.01e-218 682.0
TLS3_k127_8032814_10 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000000000006327 136.0
TLS3_k127_8032814_11 YCII-related domain K05527,K09780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000002702 84.0
TLS3_k127_8032814_12 Transposase - - - 0.0000000000000003869 78.0
TLS3_k127_8032814_13 - - - - 0.0007567 47.0
TLS3_k127_8032814_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 2.816e-200 631.0
TLS3_k127_8032814_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 505.0
TLS3_k127_8032814_4 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 406.0
TLS3_k127_8032814_5 Imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009433 357.0
TLS3_k127_8032814_6 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 301.0
TLS3_k127_8032814_7 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000003832 239.0
TLS3_k127_8032814_8 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000000000000000000000000000000000006557 181.0
TLS3_k127_8032814_9 Transposase - - - 0.0000000000000000000000000000000000000000000001146 170.0
TLS3_k127_8139340_0 ABC transporter K06020 - 3.6.3.25 0.0 1024.0
TLS3_k127_8139340_1 GAF domain - - - 1.911e-293 913.0
TLS3_k127_8139340_10 PFAM Citrate transporter - - - 7.525e-201 636.0
TLS3_k127_8139340_11 efflux transmembrane transporter activity - - - 5.452e-197 625.0
TLS3_k127_8139340_12 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009707 592.0
TLS3_k127_8139340_13 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 582.0
TLS3_k127_8139340_14 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 563.0
TLS3_k127_8139340_15 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K02022,K06147,K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007759 514.0
TLS3_k127_8139340_16 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 392.0
TLS3_k127_8139340_17 dTDP-4-dehydrorhamnose reductase activity K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 338.0
TLS3_k127_8139340_18 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00350 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 328.0
TLS3_k127_8139340_19 Alpha/beta hydrolase family K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004356 328.0
TLS3_k127_8139340_2 radical SAM domain protein K04034 - 1.21.98.3 2.654e-260 809.0
TLS3_k127_8139340_20 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00349 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 323.0
TLS3_k127_8139340_21 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00348 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 312.0
TLS3_k127_8139340_22 thiolester hydrolase activity K06889,K07000 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 313.0
TLS3_k127_8139340_23 Protein of unknown function (DUF1295) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 306.0
TLS3_k127_8139340_24 3-isopropylmalate dehydrogenase activity K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000009154 162.0
TLS3_k127_8139340_25 Transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.000000000000000000000000000000001441 134.0
TLS3_k127_8139340_26 Nodulation protein S (NodS) - - - 0.000000000000000000000000001218 122.0
TLS3_k127_8139340_27 sulfate reduction K00390,K00957 - 1.8.4.10,1.8.4.8,2.7.7.4 0.0000000000000000000000000221 114.0
TLS3_k127_8139340_29 Cytochrome c K12263 - - 0.000000000000000005046 91.0
TLS3_k127_8139340_3 Uncharacterized ACR, YdiU/UPF0061 family K08997 - - 6.239e-244 763.0
TLS3_k127_8139340_30 Protein conserved in bacteria K03734,K05952 - 2.7.1.180 0.0000000000000007761 78.0
TLS3_k127_8139340_32 sulfate reduction K00390,K00957 - 1.8.4.10,1.8.4.8,2.7.7.4 0.0001461 47.0
TLS3_k127_8139340_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 3.917e-222 697.0
TLS3_k127_8139340_5 Bacterial regulatory protein, Fis family K07714 - - 1.057e-216 680.0
TLS3_k127_8139340_6 Oxidoreductase FAD-binding domain - - - 9.667e-211 661.0
TLS3_k127_8139340_7 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 - 1.6.5.8 9.134e-209 658.0
TLS3_k127_8139340_8 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00347 - 1.6.5.8 1.396e-206 647.0
TLS3_k127_8139340_9 protein secretion by the type I secretion system K02021 - - 1.613e-205 653.0
TLS3_k127_8300856_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K06147,K11085 - - 3.1e-268 837.0
TLS3_k127_8300856_1 FAD binding domain K00278 - 1.4.3.16 9.106e-255 797.0
TLS3_k127_8300856_10 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 430.0
TLS3_k127_8300856_11 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 429.0
TLS3_k127_8300856_12 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826,K02619 - 2.6.1.42,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 389.0
TLS3_k127_8300856_13 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 371.0
TLS3_k127_8300856_14 tRNA processing K06864,K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006252 358.0
TLS3_k127_8300856_15 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 305.0
TLS3_k127_8300856_17 nitric oxide dioxygenase activity K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 284.0
TLS3_k127_8300856_18 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001331 282.0
TLS3_k127_8300856_19 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001054 275.0
TLS3_k127_8300856_2 Endoribonuclease that initiates mRNA decay K18682 - - 7.216e-253 788.0
TLS3_k127_8300856_20 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000002525 268.0
TLS3_k127_8300856_22 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000504 247.0
TLS3_k127_8300856_24 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000008543 175.0
TLS3_k127_8300856_25 AAA domain - - - 0.00000000000000000000000000000000000000001783 175.0
TLS3_k127_8300856_26 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.000000000000000000000000000000000001547 142.0
TLS3_k127_8300856_28 COGs COG1112 Superfamily I DNA and RNA helicase and helicase subunits - - - 0.0000000000000000000000000000000003594 148.0
TLS3_k127_8300856_29 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000000000000001797 132.0
TLS3_k127_8300856_30 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000005592 128.0
TLS3_k127_8300856_31 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000000000000000000000000000007288 127.0
TLS3_k127_8300856_33 exodeoxyribonuclease VII activity K03602 - 3.1.11.6 0.00000000000000000000000003826 109.0
TLS3_k127_8300856_34 AntiSigma factor - - - 0.000000000000000000000002946 106.0
TLS3_k127_8300856_35 - - - - 0.00000000000000001854 95.0
TLS3_k127_8300856_4 Transglycosylase SLT domain K08309 - - 8.926e-227 725.0
TLS3_k127_8300856_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 2.697e-220 691.0
TLS3_k127_8300856_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 1.018e-204 646.0
TLS3_k127_8300856_7 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01665 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046820,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 557.0
TLS3_k127_8300856_8 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 471.0
TLS3_k127_8300856_9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 459.0
TLS3_k127_8418275_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.544e-217 681.0
TLS3_k127_8418275_1 - - - - 0.0000006536 54.0
TLS3_k127_8464701_0 Glucoamylase and related glycosyl hydrolases - - - 7.289e-254 796.0
TLS3_k127_8464701_1 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 584.0
TLS3_k127_8464701_2 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 322.0
TLS3_k127_8464701_3 Cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 314.0
TLS3_k127_8464701_4 signal-transduction protein containing cAMP-binding and CBS domains K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000008135 169.0
TLS3_k127_8464701_5 PFAM blue (type 1) copper domain protein K00368 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 0.000000000000000000001523 100.0
TLS3_k127_8486908_0 Uncharacterized protein conserved in bacteria (DUF2309) K09822 - - 0.0 1439.0
TLS3_k127_8486908_1 Beta-Casp domain K07576 - - 5.991e-235 736.0
TLS3_k127_8486908_10 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002388 280.0
TLS3_k127_8486908_11 Calcium/calmodulin dependent protein kinase II association domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001181 284.0
TLS3_k127_8486908_12 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000001778 228.0
TLS3_k127_8486908_14 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000004426 215.0
TLS3_k127_8486908_15 Carbonic Anhydrase K01674 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000002088 211.0
TLS3_k127_8486908_16 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000000001317 193.0
TLS3_k127_8486908_17 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000001573 194.0
TLS3_k127_8486908_19 RF-1 domain K15034 - - 0.000000000000000000000000000000000000000000008879 166.0
TLS3_k127_8486908_2 NADH-quinone oxidoreductase K00341,K05577 - 1.6.5.3 3.882e-231 728.0
TLS3_k127_8486908_20 Uncharacterized conserved protein (DUF2294) - - - 0.000000000000000000000000000000000000000000009277 166.0
TLS3_k127_8486908_21 acetyltransferase - - - 0.00000000000000000000000000000000000000000001187 167.0
TLS3_k127_8486908_22 - - - - 0.000000000000000000000000000000000000000000503 171.0
TLS3_k127_8486908_23 - - - - 0.0000000000000000000000000000000000000000006357 164.0
TLS3_k127_8486908_24 Protein of unknown function (DUF2490) - - - 0.00000000000000000000000000000000000008725 151.0
TLS3_k127_8486908_26 tetraacyldisaccharide 4'-kinase activity K09791 - - 0.0000000000000000000000000000003651 124.0
TLS3_k127_8486908_28 hmm pf01609 - - - 0.000000000000000000000002512 112.0
TLS3_k127_8486908_3 NADH-quinone oxidoreductase K00341,K05577 - 1.6.5.3 3.541e-220 696.0
TLS3_k127_8486908_30 - - - - 0.00000000000001457 76.0
TLS3_k127_8486908_31 Bacterial regulatory helix-turn-helix protein, lysR family K03717 - - 0.0000008843 53.0
TLS3_k127_8486908_4 Sulfate permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 618.0
TLS3_k127_8486908_5 aminopeptidase activity K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 552.0
TLS3_k127_8486908_6 FIST C domain - GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 464.0
TLS3_k127_8486908_7 Aminomethyltransferase folate-binding domain K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 461.0
TLS3_k127_8486908_8 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 421.0
TLS3_k127_8486908_9 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 398.0
TLS3_k127_870499_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001046 243.0
TLS3_k127_870499_1 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000002418 226.0
TLS3_k127_870499_3 - - - - 0.0000000005971 63.0
TLS3_k127_892500_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 4.707e-282 874.0
TLS3_k127_892500_1 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 389.0
TLS3_k127_892500_2 Integrase core domain K07497 - - 0.0000000000000000000000000000000000000000000000000001774 191.0
TLS3_k127_892500_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000000000000000000002177 180.0
TLS3_k127_892500_4 Hsp20/alpha crystallin family - - - 0.00000000000000000000000000000000000000000000001283 174.0
TLS3_k127_892500_5 PFAM Usg family protein - - - 0.0000000000000000000007445 97.0
TLS3_k127_892500_6 CBS domain - - - 0.000000000000000000007931 100.0
TLS3_k127_892500_7 Evidence 4 Homologs of previously reported genes of - - - 0.0000000007833 66.0
TLS3_k127_91344_0 Type II/IV secretion system protein K02454,K02652 - - 4.422e-294 910.0
TLS3_k127_91344_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 7.921e-277 873.0
TLS3_k127_91344_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 557.0
TLS3_k127_91344_11 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 526.0
TLS3_k127_91344_12 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 520.0
TLS3_k127_91344_13 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 516.0
TLS3_k127_91344_14 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009836 512.0
TLS3_k127_91344_15 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 394.0
TLS3_k127_91344_16 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009309 301.0
TLS3_k127_91344_17 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006634 274.0
TLS3_k127_91344_18 Pilus assembly protein K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006566 272.0
TLS3_k127_91344_19 general secretion pathway protein K02456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003383 250.0
TLS3_k127_91344_2 Type ii and iii secretion system protein K02453 - - 2.359e-252 801.0
TLS3_k127_91344_20 PFAM Integrase, catalytic K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004052 250.0
TLS3_k127_91344_21 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000000000000000000004108 237.0
TLS3_k127_91344_22 general secretion pathway protein K10927 - - 0.0000000000000000000000000000000000000000000000000000000000004951 216.0
TLS3_k127_91344_23 Pfam 2OG-Fe(II) oxygenase - - - 0.000000000000000000000000000000000000000000000000000009413 195.0
TLS3_k127_91344_25 PFAM Fimbrial assembly family protein K02461,K02662,K02663,K12289 - - 0.00000000000000000000000000000000000000000000000004379 185.0
TLS3_k127_91344_26 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000001236 183.0
TLS3_k127_91344_27 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000008252 165.0
TLS3_k127_91344_28 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000000000000000001451 159.0
TLS3_k127_91344_29 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000611 156.0
TLS3_k127_91344_3 Tetratricopeptide repeat - - - 2.394e-231 724.0
TLS3_k127_91344_30 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000000000000000000000006974 145.0
TLS3_k127_91344_31 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000002156 141.0
TLS3_k127_91344_32 PFAM Integrase catalytic region K07497 - - 0.000000000000000000000000000000009957 130.0
TLS3_k127_91344_33 cellulase activity K18197 - 4.2.2.23 0.00000000000000000000000000001125 137.0
TLS3_k127_91344_34 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - 0.000000000000000000000007291 109.0
TLS3_k127_91344_37 gluconolactonase activity K14274,K20274 - - 0.000000000000000003022 100.0
TLS3_k127_91344_38 COG1388 FOG LysM repeat K19220,K19223,K19224 - - 0.00007612 53.0
TLS3_k127_91344_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 9.456e-228 711.0
TLS3_k127_91344_5 Phosphoglycerate kinase K00927 - 2.7.2.3 2.441e-218 682.0
TLS3_k127_91344_6 peptidyl-tyrosine sulfation - - - 4.778e-199 635.0
TLS3_k127_91344_7 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 6.664e-198 627.0
TLS3_k127_91344_8 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 590.0
TLS3_k127_91344_9 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 554.0
TLS3_k127_949832_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.0 1136.0
TLS3_k127_949832_1 Elongation factor G C-terminus K06207 - - 0.0 1041.0
TLS3_k127_949832_10 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.000000000000000000000000000000000000000000000000000000000000000000000000001862 261.0
TLS3_k127_949832_11 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000134 247.0
TLS3_k127_949832_12 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004135 244.0
TLS3_k127_949832_14 Iron-sulphur cluster biosynthesis K13628 - - 0.00000000000000000000000000000000000000000000000000000000000000159 220.0
TLS3_k127_949832_15 nitric oxide dioxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000001688 225.0
TLS3_k127_949832_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000001474 215.0
TLS3_k127_949832_17 cell redox homeostasis K03671,K03672 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000007555 209.0
TLS3_k127_949832_18 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0000000000000000000000000000000000000000000000000000000003447 209.0
TLS3_k127_949832_19 - - - - 0.00000000000000000000000000000000000000000118 161.0
TLS3_k127_949832_2 Hsp70 protein K04043,K04044 - - 3.5e-323 997.0
TLS3_k127_949832_21 Iron-sulphur cluster assembly - - - 0.00000000000000000000000000000000006459 135.0
TLS3_k127_949832_22 - - - - 0.00000000000000000000000000000000008284 141.0
TLS3_k127_949832_23 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000137 133.0
TLS3_k127_949832_24 Transmembrane anti-sigma factor - - - 0.0000000000000000001294 91.0
TLS3_k127_949832_25 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372 - 0.0000000000000005364 80.0
TLS3_k127_949832_26 SpoVT / AbrB like domain - - - 0.00000000000003169 75.0
TLS3_k127_949832_27 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000001555 59.0
TLS3_k127_949832_28 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000003302 53.0
TLS3_k127_949832_3 glutamate-tRNA ligase activity K01886 GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 8.363e-295 912.0
TLS3_k127_949832_4 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 5.87e-255 795.0
TLS3_k127_949832_5 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 5.555e-224 700.0
TLS3_k127_949832_6 Alcohol dehydrogenase GroES-like domain K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 479.0
TLS3_k127_949832_7 AhpC/TSA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 287.0
TLS3_k127_949832_8 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000224 261.0
TLS3_k127_949832_9 DnaJ molecular chaperone homology domain K04082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003581 263.0
TLS3_k127_957563_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2537.0
TLS3_k127_957563_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1679.0
TLS3_k127_957563_10 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000001538 89.0
TLS3_k127_957563_11 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000003681 85.0
TLS3_k127_957563_12 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000006563 77.0
TLS3_k127_957563_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1280.0
TLS3_k127_957563_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 468.0
TLS3_k127_957563_4 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 402.0
TLS3_k127_957563_5 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 323.0
TLS3_k127_957563_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009859 248.0
TLS3_k127_957563_7 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000002114 237.0
TLS3_k127_957563_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000007221 222.0
TLS3_k127_957563_9 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000000006433 93.0